Valerie M. Weaver - Publications

Affiliations: 
1999-2006 University of Pennsylvania, Philadelphia, PA, United States 
 2006- University of California, San Francisco, San Francisco, CA 
Area:
Extracellular matrix tissue mechanics mechanobiology
Website:
https://weaverlab.ucsf.edu/PI

211 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Parihar K, Ko SH, Bradley R, Taylor P, Ramakrishnan N, Baumgart T, Guo W, Weaver VM, Janmey PA, Radhakrishnan R. Free energy calculations for membrane morphological transformations and insights to physical biology and oncology. Methods in Enzymology. 701: 359-386. PMID 39025576 DOI: 10.1016/bs.mie.2024.03.028  0.308
2024 Parihar K, Ko SB, Bradley RP, Taylor P, Ramakrishnan N, Baumgart T, Guo W, Weaver VM, Janmey PA, Radhakrishnan R. Asymmetric crowders and membrane morphology at the nexus of intracellular trafficking and oncology. Mechanobiology in Medicine. 2. PMID 38899029 DOI: 10.1016/j.mbm.2024.100071  0.345
2024 Tharp KM, Kersten K, Maller O, Timblin GA, Stashko C, Canale FP, Menjivar RE, Hayward MK, Berestjuk I, Ten Hoeve J, Samad B, Ironside AJ, di Magliano MP, Muir A, Geiger R, ... ... Weaver VM, et al. Tumor-associated macrophages restrict CD8 T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment. Nature Cancer. PMID 38831058 DOI: 10.1038/s43018-024-00775-4  0.73
2024 Goyette MA, Stevens LE, DePinho CR, Seehawer M, Nishida J, Li Z, Wilde CM, Li R, Qiu X, Pyke AL, Zhao S, Lim K, Tender GS, Northey JJ, Riley NM, ... ... Weaver VM, et al. Cancer-stromal cell interactions in breast cancer brain metastases induce glycocalyx-mediated resistance to HER2-targeting therapies. Proceedings of the National Academy of Sciences of the United States of America. 121: e2322688121. PMID 38709925 DOI: 10.1073/pnas.2322688121  0.498
2024 Northey JJ, Hayward MK, Yui Y, Stashko C, Kai F, Mouw JK, Thakar D, Lakins JN, Ironside AJ, Samson S, Mukhtar RA, Hwang ES, Weaver VM. Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk. Cell Stem Cell. 31: 106-126.e13. PMID 38181747 DOI: 10.1016/j.stem.2023.12.002  0.336
2023 Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. Expression of Concern: α6β4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-κB-dependent resistance to apoptosis in 3D mammary acini. Journal of Cell Science. 136. PMID 37855733 DOI: 10.1242/jcs.261623  0.769
2023 Tharp K, Park S, Timblin G, Richards A, Twells N, Riley N, Peltan E, Shon J, Stevenson E, Tsui K, Palomba F, Lefebvre A, Soens R, Ayad N, Hoeve-Scott JT, ... ... Weaver VM, et al. The microenvironment dictates glycocalyx construction and immune surveillance. Research Square. PMID 37645943 DOI: 10.21203/rs.3.rs-3164966/v1  0.781
2023 Pedram K, Shon DJ, Tender GS, Mantuano NR, Northey JJ, Metcalf KJ, Wisnovsky SP, Riley NM, Forcina GC, Malaker SA, Kuo A, George BM, Miller CL, Casey KM, Vilches-Moure JG, ... ... Weaver VM, et al. Design of a mucin-selective protease for targeted degradation of cancer-associated mucins. Nature Biotechnology. PMID 37537499 DOI: 10.1038/s41587-023-01840-6  0.47
2023 Stashko C, Hayward MK, Northey JJ, Pearson N, Ironside AJ, Lakins JN, Oria R, Goyette MA, Mayo L, Russnes HG, Hwang ES, Kutys ML, Polyak K, Weaver VM. A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer. Nature Communications. 14: 3561. PMID 37322009 DOI: 10.1038/s41467-023-39085-1  0.369
2023 Kersten K, You R, Liang S, Tharp KM, Pollack J, Weaver VM, Krummel MF, Headley MB. Uptake of tumor-derived microparticles induces metabolic reprogramming of macrophages in the early metastatic lung. Cell Reports. 42: 112582. PMID 37261951 DOI: 10.1016/j.celrep.2023.112582  0.739
2023 Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, ... ... Weaver VM, et al. Stiff matrix induces exosome secretion to promote tumour growth. Nature Cell Biology. PMID 36797475 DOI: 10.1038/s41556-023-01092-1  0.357
2023 Northey JJ, Weaver VM. Extracellular Matrix Glycation and Crosslinking in Mammary Tumor Progression. Methods in Molecular Biology (Clifton, N.J.). 2614: 247-260. PMID 36587129 DOI: 10.1007/978-1-0716-2914-7_15  0.387
2022 Bell ES, Shah P, Zuela-Sopilniak N, Kim D, Varlet AA, Morival JLP, McGregor AL, Isermann P, Davidson PM, Elacqua JJ, Lakins JN, Vahdat L, Weaver VM, Smolka MB, Span PN, et al. Low lamin A levels enhance confined cell migration and metastatic capacity in breast cancer. Oncogene. PMID 35896617 DOI: 10.1038/s41388-022-02420-9  0.367
2022 Northey JJ, Weaver VM. Mechanosensitive steroid hormone signaling and cell fate. Endocrinology. PMID 35678467 DOI: 10.1210/endocr/bqac085  0.316
2022 Metcalf KJ, Hayward MK, Berens E, Ironside AJ, Stashko C, Hwang ES, Weaver VM. Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression. Matrix Biology Plus. 14: 100105. PMID 35392183 DOI: 10.1016/j.mbplus.2022.100105  0.329
2022 Samson S, Northey JJ, Acerbi I, Goga A, Flink CL, Weaver VM, LaBarge MA. NCI's publication affiliation conundrum: Reframing innovation to incentivize an equitable path for advocate representation. Translational Oncology. 16: 101325. PMID 34974281 DOI: 10.1016/j.tranon.2021.101325  0.532
2021 Rudnick JA, Monkkonen T, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Bustamante Eguiguren S, Weaver VM, Debnath J. Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis. Genes & Development. PMID 34168038 DOI: 10.1101/gad.345629.120  0.391
2021 Hayward MK, Muncie JM, Weaver VM. Tissue mechanics in stem cell fate, development, and cancer. Developmental Cell. PMID 34107299 DOI: 10.1016/j.devcel.2021.05.011  0.419
2021 Tharp KM, Higuchi-Sanabria R, Timblin GA, Ford B, Garzon-Coral C, Schneider C, Muncie JM, Stashko C, Daniele JR, Moore AS, Frankino PA, Homentcovschi S, Manoli SS, Shao H, Richards AL, ... ... Weaver VM, et al. Adhesion-mediated mechanosignaling forces mitohormesis. Cell Metabolism. PMID 34019840 DOI: 10.1016/j.cmet.2021.04.017  0.724
2021 Drain AP, Zahir N, Northey JJ, Zhang H, Huang PJ, Maller O, Lakins JN, Yu X, Leight JL, Alston-Mills BP, Hwang ES, Chen YY, Park CC, Weaver VM. Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer. The Journal of Experimental Medicine. 218. PMID 33822843 DOI: 10.1084/jem.20191360  0.794
2021 Metcalf KJ, Alazzeh A, Werb Z, Weaver VM. Leveraging microenvironmental synthetic lethalities to treat cancer. The Journal of Clinical Investigation. 131. PMID 33720045 DOI: 10.1172/JCI143765  0.536
2020 Barkovskaya A, Buffone A, Žídek M, Weaver VM. Proteoglycans as Mediators of Cancer Tissue Mechanics. Frontiers in Cell and Developmental Biology. 8: 569377. PMID 33330449 DOI: 10.3389/fcell.2020.569377  0.391
2020 Maller O, Drain AP, Barrett AS, Borgquist S, Ruffell B, Zakharevich I, Pham TT, Gruosso T, Kuasne H, Lakins JN, Acerbi I, Barnes JM, Nemkov T, Chauhan A, Gruenberg J, ... ... Weaver VM, et al. Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. Nature Materials. PMID 33257795 DOI: 10.1038/s41563-020-00849-5  0.552
2020 Muncie JM, Ayad NME, Lakins JN, Xue X, Fu J, Weaver VM. Mechanical Tension Promotes Formation of Gastrulation-like Nodes and Patterns Mesoderm Specification in Human Embryonic Stem Cells. Developmental Cell. PMID 33207224 DOI: 10.1016/j.devcel.2020.10.015  0.334
2020 Weaver VM, Bissell MJ. Zena Werb (1945-2020): Mourning the loss of a tissue microenvironment icon. Proceedings of the National Academy of Sciences of the United States of America. PMID 33122428 DOI: 10.1073/pnas.2020162117  0.449
2020 Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, ... ... Weaver VM, et al. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Science Translational Medicine. 12. PMID 32817366 DOI: 10.1126/Scitranslmed.Aay8798  0.3
2020 Jiang H, Torphy RJ, Steiger K, Hongo H, Ritchie AJ, Kriegsmann M, Horst D, Umetsu SE, Joseph NM, McGregor K, Pishvaian MJ, Blais EM, Lu B, Li M, Hollingsworth M, ... ... Weaver VM, et al. Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix. The Journal of Clinical Investigation. PMID 32749238 DOI: 10.1172/Jci136760  0.402
2020 Northey JJ, Barrett AS, Acerbi I, Hayward MK, Talamantes S, Dean IS, Mouw JK, Ponik SM, Lakins JN, Huang PJ, Wu J, Shi Q, Samson S, Keely PJ, Mukhtar RA, ... ... Weaver VM, et al. Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217. The Journal of Clinical Investigation. PMID 32721948 DOI: 10.1172/Jci129249  0.377
2020 Piersma B, Hayward MK, Weaver VM. The fibrotic tumor stroma. Biochimica Et Biophysica Acta. Reviews On Cancer. 188356. PMID 32147542 DOI: 10.1016/J.Bbcan.2020.188356  0.479
2020 Ayad NME, Weaver VM. Tension in tumour cells keeps metabolism high. Nature. 578: 517-518. PMID 32094916 DOI: 10.1038/D41586-020-00314-Y  0.304
2020 Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, Fearon D, Greten FR, Hingorani SR, Hunter T, Hynes RO, Jain RK, Janowitz T, Jorgensen C, Kimmelman AC, ... ... Weaver V, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nature Reviews. Cancer. PMID 31980749 DOI: 10.1038/S41568-019-0238-1  0.557
2020 Buffone A, Weaver VM. Don't sugarcoat it: How glycocalyx composition influences cancer progression. The Journal of Cell Biology. 219. PMID 31874115 DOI: 10.1083/Jcb.201910070  0.496
2020 Tsai K, Weaver VM. Abstract A49: A dual blockade of N-CoR2- and immune checkpoints induces complete remissions in treatment-refractory tumors Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm18-A49  0.402
2019 Muncie JM, Falcón-Banchs R, Lakins JN, Sohn LL, Weaver VM. Patterning the Geometry of Human Embryonic Stem Cell Colonies on Compliant Substrates to Control Tissue-Level Mechanics. Journal of Visualized Experiments : Jove. PMID 31609314 DOI: 10.3791/60334  0.385
2019 Zheng Y, Xue X, Shao Y, Wang S, Esfahani SN, Li Z, Muncie JM, Lakins JN, Weaver VM, Gumucio DL, Fu J. Controlled modelling of human epiblast and amnion development using stem cells. Nature. PMID 31511693 DOI: 10.1038/S41586-019-1535-2  0.339
2019 Eliazer S, Muncie JM, Christensen J, Sun X, D'Urso RS, Weaver VM, Brack AS. Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells. Cell Stem Cell. PMID 31495781 DOI: 10.1016/J.Stem.2019.08.007  0.349
2019 Ayad NME, Kaushik S, Weaver VM. Tissue mechanics, an important regulator of development and disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 374: 20180215. PMID 31431174 DOI: 10.1098/Rstb.2018.0215  0.43
2019 Kai F, Drain AP, Weaver VM. The Extracellular Matrix Modulates the Metastatic Journey. Developmental Cell. 49: 332-346. PMID 31063753 DOI: 10.1016/J.Devcel.2019.03.026  0.467
2019 Huang S, Weaver VM, Tsai KKC. Abstract 5184: N-CoR2 epigenetically regulates adhesion-dependent branching morphogenesis and its loss correlates with malignant progression of the mammary gland Cancer Research. 79: 5184-5184. DOI: 10.1158/1538-7445.Sabcs18-5184  0.454
2019 Kai F, Ou G, Long A, Guo W, Tourdot R, Radhakrishnan R, Chen C, Dumont S, Weaver VM. Abstract 1028: Extracellular matrix dimensionality reduces cellular cortical tension to stimulate pro-survival signaling in mammary epithelial cells Cancer Research. 79: 1028-1028. DOI: 10.1158/1538-7445.Am2019-1028  0.467
2018 Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC. Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference. Elife. 7. PMID 30298816 DOI: 10.7554/Elife.36045  0.376
2018 Barnes JM, Kaushik S, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lee M, Lee HW, Tung JC, Maller O, Barrett AS, Lu KV, Lakins JN, Hansen KC, ... ... Weaver VM, et al. A tension-mediated glycocalyx-integrin feedback loop promotes mesenchymal-like glioblastoma. Nature Cell Biology. PMID 30202050 DOI: 10.1038/S41556-018-0183-3  0.541
2018 Tharp KM, Weaver VM. Modeling tissue polarity in context. Journal of Molecular Biology. PMID 30055167 DOI: 10.1016/J.Jmb.2018.07.015  0.767
2018 Sampayo RG, Toscani AM, Rubashkin MG, Thi K, Masullo LA, Violi IL, Lakins JN, Cáceres A, Hines WC, Coluccio Leskow F, Stefani FD, Chialvo DR, Bissell MJ, Weaver VM, Simian M. Fibronectin rescues estrogen receptor α from lysosomal degradation in breast cancer cells. The Journal of Cell Biology. PMID 29980625 DOI: 10.1083/Jcb.201703037  0.778
2018 Muncie JM, Weaver VM. The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate. Current Topics in Developmental Biology. 130: 1-37. PMID 29853174 DOI: 10.1016/Bs.Ctdb.2018.02.002  0.478
2018 Samson S, Northey JJ, Plaks V, Baas C, Dean I, LaBarge MA, Goga A, Van't Veer LJ, Weaver VM. New Horizons in Advocacy Engaged Physical Sciences and Oncology Research. Trends in Cancer. 4: 260-264. PMID 29606307 DOI: 10.1016/J.Trecan.2018.02.002  0.593
2018 Northcott JM, Dean IS, Mouw JK, Weaver VM. Feeling Stress: The Mechanics of Cancer Progression and Aggression. Frontiers in Cell and Developmental Biology. 6: 17. PMID 29541636 DOI: 10.3389/Fcell.2018.00017  0.484
2018 Takai K, Drain AP, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes & Development. PMID 29483153 DOI: 10.1101/Gad.301366.117  0.623
2018 Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley D, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw J, ... ... Weaver VM, et al. Antisecretory Factor-mediated Inhibition of Cell Volume Dynamics Produces Anti-tumor Activity in Glioblastoma. Molecular Cancer Research : McR. PMID 29431617 DOI: 10.1158/1541-7786.Mcr-17-0413  0.391
2018 Weaver VM. Cell and tissue mechanics: the new cell biology frontier. Molecular Biology of the Cell. 28: 1815-1818. PMID 28684606 DOI: 10.1091/Mbc.E17-05-0320  0.41
2018 Drain AP, Takai K, Lawson DA, Littlepage LE, Karpuj M, Kessenbrock K, Le A, Inoue K, Weaver VM, Werb Z. Abstract LB-055: Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive, basal-like breast cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-055  0.635
2018 Kaushik S, Barnes JM, Bainer RO, Sa JK, Woods EC, Kai F, Przybyla L, Lakins JN, Phillips JJ, Nam D, Bertozzi CR, Weaver VM. TMIC-43. A TENSION-MEDIATED GLYCOCALYX FEEDBACK LOOP PROMOTES A MESENCHYMAL, STEM-LIKE PHENOTYPE IN GLIOBLASTOMA Neuro-Oncology. 20: vi265-vi266. DOI: 10.1093/Neuonc/Noy148.1102  0.452
2018 Barrett AS, Maller O, Pickup MW, Weaver VM, Hansen KC. Compartment resolved proteomics reveals a dynamic matrisome in a biomechanically driven model of pancreatic ductal adenocarcinoma Journal of Immunology and Regenerative Medicine. 1: 67-75. DOI: 10.1016/J.Regen.2018.03.002  0.386
2017 Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. Elife. 6. PMID 29266001 DOI: 10.7554/Elife.25752  0.615
2017 Northey JJ, Przybyla L, Weaver VM. Tissue Force Programs Cell Fate and Tumor Aggression. Cancer Discovery. PMID 29038232 DOI: 10.1158/2159-8290.Cd-16-0733  0.496
2017 Miroshnikova YA, Rozenberg GI, Cassereau L, Pickup M, Mouw JK, Ou G, Templeman KL, Elloumi-Hannachi I, Gooch K, Sarang-Sieminski AL, García AJ, Weaver VM. α5β1-integrinpromotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Molecular Biology of the Cell. PMID 28877984 DOI: 10.1091/Mbc.E17-02-0126  0.501
2017 Pickup MW, Owens P, Gorska AE, Chytil A, Ye F, Shi C, Weaver VM, Kalluri R, Moses HL, Novitskiy SV. Development of aggressive pancreatic ductal adenocarcinomas depends on granulocyte-colony stimulating factor secretion in carcinoma cells. Cancer Immunology Research. PMID 28775207 DOI: 10.1158/2326-6066.Cir-16-0311  0.403
2017 Salvador F, Martin A, López-Menéndez C, Moreno-Bueno G, Santos V, Vazquez-Naharro A, Santamaría PG, Morales S, Dubus P, Muinelo-Romay L, López López R, Tung JC, Weaver VM, Portillo F, Cano A. Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer. Cancer Research. PMID 28720577 DOI: 10.1158/0008-5472.Can-16-3152  0.485
2017 Oudin MJ, Weaver VM. Physical and Chemical Gradients in the Tumor Microenvironment Regulate Tumor Cell Invasion, Migration, and Metastasis. Cold Spring Harbor Symposia On Quantitative Biology. PMID 28424337 DOI: 10.1101/Sqb.2016.81.030817  0.468
2017 Mekhdjian AH, Kai F, Rubashkin MG, Prahl LS, Przybyla LM, McGregor AL, Bell ES, Barnes JM, DuFort CC, Ou G, Chang AC, Cassereau L, Tan SJ, Pickup MW, Lakins JN, ... ... Weaver VM, et al. Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Molecular Biology of the Cell. PMID 28381423 DOI: 10.1091/Mbc.E16-09-0654  0.502
2017 Barnes JM, Przybyla L, Weaver VM. Tissue mechanics regulate brain development, homeostasis and disease. Journal of Cell Science. 130: 71-82. PMID 28043968 DOI: 10.1242/Jcs.191742  0.441
2017 Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi CR. Author response: A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression Elife. DOI: 10.7554/Elife.25752.021  0.49
2017 Dean I, Acerbi I, Mouw J, Shi Q, Chen Y, Liphardt J, Hwang S, Weaver V. Abstract C24: Interplay between ECM stiffness, miR-203 and mammographic density Cancer Epidemiology, Biomarkers & Prevention. 26. DOI: 10.1158/1538-7755.Disp16-C24  0.375
2017 Barnes JM, Woods EC, Bainer RO, Miroshnikova YA, Lu K, Bergers G, Bertozzi C, Weaver VM. Abstract PR05: Glycoprotein-mediated tissue mechanics regulate glioblastoma aggression Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Pr05  0.641
2017 Weaver V. Abstract IA09: Extrinsic and intrinsic force regulate cancer progression and aggression Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Ia09  0.543
2017 Thakar D, Low-Nam ST, Groves JT, Weaver VM. Abstract 5912: Tumor micoenvironment modulates RTK signaling Cancer Research. 77: 5912-5912. DOI: 10.1158/1538-7445.Am2017-5912  0.34
2017 Tsai KK, Chan T, Hsu C, Pai VC, Huang S, Weaver VM. Abstract 4763: Metronomic chemotherapy prevents therapy-induced stromal activation and induction of cancer stem cells Cancer Research. 77: 4763-4763. DOI: 10.1158/1538-7445.Am2017-4763  0.424
2017 Kaushik S, Phillips JJ, Weaver VM. Abstract 3985: NCoR2 regulates glioblastoma progression and treatment resistance Cancer Research. 77: 3985-3985. DOI: 10.1158/1538-7445.Am2017-3985  0.426
2017 Zhang H, Ziaee S, Silva BA, Weaver V, Park C. Stromal Stiffness Increases YAP-Dependent Mediated Cell Survival of Breast Cancer Cells International Journal of Radiation Oncology*Biology*Physics. 99: S149. DOI: 10.1016/j.ijrobp.2017.06.345  0.311
2016 Chang TT, Thakar D, Weaver VM. Force-dependent breaching of the basement membrane. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 28025167 DOI: 10.1016/J.Matbio.2016.12.005  0.431
2016 Kaushik S, Pickup MW, Weaver VM. From transformation to metastasis: deconstructing the extracellular matrix in breast cancer. Cancer Metastasis Reviews. PMID 27914000 DOI: 10.1007/S10555-016-9650-0  0.482
2016 Chan TS, Hsu CC, Pai VC, Liao WY, Huang SS, Tan KT, Yen CJ, Hsu SC, Chen WY, Shan YS, Li CR, Lee MT, Jiang KY, Chu JM, Lien GS, ... Weaver VM, et al. Metronomic chemotherapy prevents therapy-induced stromal activation and induction of tumor-initiating cells. The Journal of Experimental Medicine. PMID 27881732 DOI: 10.1084/Jem.20151665  0.435
2016 Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1α-tenascin C feedback to regulate glioblastoma aggression. Nature Cell Biology. PMID 27820599 DOI: 10.1038/Ncb3429  0.387
2016 Takai K, Le A, Weaver VM, Werb Z. Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer. Oncotarget. PMID 27756881 DOI: 10.18632/Oncotarget.12658  0.593
2016 Weaver VM, Gilbert PM. Cellular adaptation to biomechanical stress across length scales in tissue homeostasis and disease. Seminars in Cell & Developmental Biology. PMID 27641825 DOI: 10.1016/J.Semcdb.2016.09.004  0.726
2016 Przybyla L, Lakins JN, Weaver VM. Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation. Cell Stem Cell. PMID 27452175 DOI: 10.1016/J.Stem.2016.06.018  0.421
2016 Ou G, Thakar D, Tung JC, Miroshnikova YA, Dufort CC, Gutierrez E, Groisman A, Weaver VM. Visualizing mechanical modulation of nanoscale organization of cell-matrix adhesions. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 27334548 DOI: 10.1039/C6Ib00031B  0.396
2016 Przybyla L, Muncie JM, Weaver VM. Mechanical Control of Epithelial-to-Mesenchymal Transitions in Development and Cancer. Annual Review of Cell and Developmental Biology. PMID 27298087 DOI: 10.1146/Annurev-Cellbio-111315-125150  0.46
2016 Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, ... ... Weaver VM, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine. PMID 27089513 DOI: 10.1038/Nm.4082  0.392
2016 Kai F, Laklai H, Weaver VM. Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends in Cell Biology. PMID 27056543 DOI: 10.1016/J.Tcb.2016.03.007  0.453
2016 Le LT, Cazares O, Mouw JK, Chatterjee S, Macias H, Moran A, Ramos J, Keely PJ, Weaver VM, Hinck L. Loss of miR-203 regulates cell shape and matrix adhesion through ROBO1/Rac/FAK in response to stiffness. The Journal of Cell Biology. 212: 707-19. PMID 26975850 DOI: 10.1083/Jcb.201507054  0.491
2016 Desai SS, Tung JC, Zhou VX, Grenert JP, Malato Y, Rezvani M, Español-Suñer R, Willenbring H, Weaver VM, Chang TT. Physiological Ranges of Matrix Rigidity Modulate Primary Mouse Hepatocyte Function In Part Through Hepatocyte Nuclear Factor 4 Alpha. Hepatology (Baltimore, Md.). PMID 26755329 DOI: 10.1002/Hep.28450  0.351
2016 Przybyla L, Lakins JN, Sunyer R, Trepat X, Weaver VM. Monitoring developmental force distributions in reconstituted embryonic epithelia. Methods (San Diego, Calif.). 94: 101-13. PMID 26342256 DOI: 10.1016/J.Ymeth.2015.09.003  0.368
2016 Maller O, Cassereau L, Drain A, Ruffell B, Acerbi I, Broz M, Munson J, Swartz M, Krummel M, Coussens L, Weaver V. Abstract A098: A role for fibrosis in promoting pro-tumor immune response in breast cancer Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A098  0.464
2016 Northey JJ, Yui Y, Mouw JK, Lakins JN, Weaver VM. Abstract PR04: Tissue tension promotes mammary stemness and breast cancer aggression Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Advbc15-Pr04  0.5
2016 Barnes JM, Miroshnikova YA, Tung JC, Bainer RO, Weaver VM. Abstract PR10: A glycoprotein-mediated mechanical switch promotes glioma aggression Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-Pr10  0.462
2016 Liu S, Bainer R, Yui Y, Flinders C, Mallick P, Weaver V, Mumenthaler S. Abstract A23: Characterization of diverging molecular and phenotypic responses under changing extracellular matrix stiffness in MCF10A cells Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-A23  0.532
2016 Gruosso T, Gigoux M, Bertos N, Saleh S, Omeroglu A, Zuo D, Zhao H, Souleimanova M, Weaver V, Meterissian S, Hallett M, Park M. Abstract A15: Mechanisms of CD8+ T cell immunosuppression in triple negative breast cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-A15  0.405
2016 Laklai H, Miroshnikova Y, Pickup M, Collisson E, Grace K, Barrett A, Hill R, Lakins J, Schlaepfer D, Mouw J, LeBleu V, Novitskiy S, Johansen J, Poli V, Kalluri R, ... ... Weaver V, et al. Abstract A50: Genotype tunes PDAC tension to induce matricellular-fibrosis and tumor aggression Cancer Research. 76. DOI: 10.1158/1538-7445.Panca16-A50  0.31
2016 Northey JJ, Damiano L, Weaver VM. Abstract 911: BRM loss promotes tumor progression through extracellular matrix remodeling and elevated mammary epithelial stem/progenitor activity Cancer Research. 76: 911-911. DOI: 10.1158/1538-7445.Am2016-911  0.444
2016 Dean I, Acerbi I, Au A, Chen Y, Hwang S, Weaver V. Abstract 5100: Interplay between ECM stiffness, miR-203 and mammographic density Cancer Research. 76: 5100-5100. DOI: 10.1158/1538-7445.Am2016-5100  0.376
2016 Weaver V. Tissue Mechanics and Disease Models Biophysical Journal. 110: 1a. DOI: 10.1016/J.Bpj.2015.11.041  0.308
2015 Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, ... ... Weaver VM, et al. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 28: 831-833. PMID 28843279 DOI: 10.1016/J.Ccell.2015.11.002  0.316
2015 Ou G, Weaver VM. Tumor-induced solid stress activates β-catenin signaling to drive malignant behavior in normal, tumor-adjacent cells. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 1293-7. PMID 26439949 DOI: 10.1002/Bies.201500090  0.449
2015 Lin C, Pelissier FA, Zhang H, Lakins J, Weaver VM, Park C, LaBarge MA. Microenvironment rigidity modulates responses to the HER2 receptor tyrosine kinase inhibitor lapatinib via YAP and TAZ transcription factors. Molecular Biology of the Cell. PMID 26337386 DOI: 10.1091/Mbc.E15-07-0456  0.691
2015 Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI. STAT3 blockade inhibits radiation-induced malignant progression in glioma. Cancer Research. PMID 26282165 DOI: 10.1158/0008-5472.Can-14-3331  0.371
2015 Acerbi I, Cassereau L, Dean I, Shi Q, Au A, Park C, Chen YY, Liphardt J, Hwang ES, Weaver VM. Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 25959051 DOI: 10.1039/C5Ib00040H  0.484
2015 Northcott JM, Northey JJ, Barnes JM, Weaver VM. Fighting the force: Potential of homeobox genes for tumor microenvironment regulation. Biochimica Et Biophysica Acta. 1855: 248-53. PMID 25818365 DOI: 10.1016/J.Bbcan.2015.03.004  0.48
2015 Tung JC, Barnes JM, Desai SR, Sistrunk C, Conklin MW, Schedin P, Eliceiri KW, Keely PJ, Seewaldt VL, Weaver VM. Tumor mechanics and metabolic dysfunction. Free Radical Biology & Medicine. 79: 269-80. PMID 25532934 DOI: 10.1016/J.Freeradbiomed.2014.11.020  0.437
2015 Cassereau L, Miroshnikova YA, Ou G, Lakins J, Weaver VM. A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype. Journal of Biotechnology. 193: 66-9. PMID 25435379 DOI: 10.1016/J.Jbiotec.2014.11.008  0.447
2015 Bainer R, Yui Y, Mumenthaler S, Mallick P, Liu L, Wu H, Podlaha O, Michor F, Liphardt J, Licht J, Weaver V. Abstract PR09: Extracellular stiffness cues drive spatial reorganization of the genome to globally constrain RNA abundance Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-Pr09  0.436
2015 Iikhanizadeh S, Miroshnikova Y, Frantz A, Zhu W, Idilli A, Quigley D, Lakins J, Magnitsky S, Phillips J, James D, Berger M, Arosio D, Sun D, Weaver V, Weiss W, et al. ATPS-63OSMOTIC SWELLING REGULATES TUMOR GROWTH AND DRUG UPTAKE IN HUMAN GLIOBLASTOMA Neuro-Oncology. 17: v32.1-v32. DOI: 10.1093/Neuonc/Nov204.63  0.415
2015 Tsai K, Weaver V. Metronomic chemotherapy prevents pancreatic cancers from enhanced stemness induced by stroma-derived ELR+ CXC-chemokine signaling Pancreatology. 15: S31. DOI: 10.1016/J.Pan.2015.05.139  0.307
2014 Pickup MW, Mouw JK, Weaver VM. The extracellular matrix modulates the hallmarks of cancer. Embo Reports. 15: 1243-53. PMID 25381661 DOI: 10.15252/Embr.201439246  0.511
2014 Mouw JK, Ou G, Weaver VM. Extracellular matrix assembly: a multiscale deconstruction. Nature Reviews. Molecular Cell Biology. 15: 771-85. PMID 25370693 DOI: 10.1038/Nrm3902  0.412
2014 Weaver VM. The microenvironment matters. Molecular Biology of the Cell. 25: 3254-8. PMID 25360044 DOI: 10.1091/Mbc.E14-06-1080  0.315
2014 Rubashkin MG, Cassereau L, Bainer R, DuFort CC, Yui Y, Ou G, Paszek MJ, Davidson MW, Chen YY, Weaver VM. Force engages vinculin and promotes tumor progression by enhancing PI3K activation of phosphatidylinositol (3,4,5)-triphosphate. Cancer Research. 74: 4597-611. PMID 25183785 DOI: 10.1158/0008-5472.Can-13-3698  0.757
2014 Venugopalan G, Camarillo DB, Webster KD, Reber CD, Sethian JA, Weaver VM, Fletcher DA, El-Samad H, Rycroft CH. Multicellular architecture of malignant breast epithelia influences mechanics. Plos One. 9: e101955. PMID 25111489 DOI: 10.1371/Journal.Pone.0101955  0.467
2014 Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, ... ... Weaver VM, et al. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 511: 319-25. PMID 25030168 DOI: 10.1038/Nature13535  0.788
2014 Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, ... ... Weaver VM, et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 25: 719-34. PMID 24856586 DOI: 10.1016/J.Ccr.2014.04.005  0.41
2014 Michor F, Weaver VM. Understanding tissue context influences on intratumour heterogeneity. Nature Cell Biology. 16: 301-2. PMID 24691256 DOI: 10.1038/Ncb2942  0.443
2014 Rubashkin MG, Ou G, Weaver VM. Deconstructing signaling in three dimensions. Biochemistry. 53: 2078-90. PMID 24649923 DOI: 10.1021/Bi401710D  0.386
2014 Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM. Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression. Nature Medicine. 20: 360-7. PMID 24633304 DOI: 10.1038/Nm.3497  0.793
2014 Shi Q, Ghosh RP, Engelke H, Rycroft CH, Cassereau L, Sethian JA, Weaver VM, Liphardt JT. Rapid disorganization of mechanically interacting systems of mammary acini. Proceedings of the National Academy of Sciences of the United States of America. 111: 658-63. PMID 24379367 DOI: 10.1073/Pnas.1311312110  0.335
2014 Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin. Oncogene. 33: 2441-53. PMID 23770848 DOI: 10.1038/Onc.2013.220  0.42
2014 Laklai H, Miroshnikova Y, lakins J, Sergey N, Gorska A, Korets L, Kalluri R, Moses H, Weaver V. Abstract LB-143: Interplay between tissue tension and inflammation in pancreatic tumor progression Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Lb-143  0.477
2014 Bainer R, Yui Y, Mumenthaler S, Mallick P, Podlaha O, Michor F, Liphardt J, Licht J, Weaver V. Abstract 2344: 3D extracellular stiffness cues drive localized changes in gene expression Cancer Research. 74: 2344-2344. DOI: 10.1158/1538-7445.Am2014-2344  0.432
2014 Ilkhanizadeh S, Miroshnikova Y, Frantz A, James D, Berger M, McKnight T, Weaver V, Weiss W, Persson A. NT-11 * TARGETING INTERSTITIAL FLUID PRESSURE TO REDUCE TUMOR GROWTH AND INCREASE DRUG UPTAKE IN BRAIN TUMORS Neuro-Oncology. 16: v161-v161. DOI: 10.1093/Neuonc/Nou265.11  0.419
2014 Persson AI, Ilkhanizadeh S, Miroshnikova YA, Frantz A, Lakins JN, James CD, McKnight TR, Berger MS, Bergers G, Weiss WA, Weaver VM. HIGH INTERSTITIAL FLUID PRESSURE REGULATES TUMOR GROWTH AND DRUG UPTAKE IN HUMAN GLIOBLASTOMA Neuro-Oncology. 16: iii32-iii32. DOI: 10.1093/Neuonc/Nou208.37  0.418
2014 Park C, Zhang H, Weaver V. Tensional Properties of Extracellular Matrix (ECM) Modulate Radiation Resistance via Yes Associated Protein (YAP) International Journal of Radiation Oncology*Biology*Physics. 90: S772. DOI: 10.1016/J.Ijrobp.2014.05.2234  0.309
2014 Rubashkin MG, Dufort C, Oakes P, Paszek M, Ou G, Lakins J, Davidson M, Gardel M, Weaver V. The Nanoscale Organization of Focal Adhesion Signaling Complexes can Reflect Changes in Cellular Contractility and Motility Biophysical Journal. 106: 575a-576a. DOI: 10.1016/J.Bpj.2013.11.3190  0.705
2013 Bainer R, Weaver V. Strength under tension Science. 341: 965-966. PMID 23990548 DOI: 10.1126/Science.1243643  0.323
2013 Pickup MW, Laklai H, Acerbi I, Owens P, Gorska AE, Chytil A, Aakre M, Weaver VM, Moses HL. Stromally derived lysyl oxidase promotes metastasis of transforming growth factor-β-deficient mouse mammary carcinomas. Cancer Research. 73: 5336-46. PMID 23856251 DOI: 10.1158/0008-5472.Can-13-0012  0.478
2013 Maller O, Hansen KC, Lyons TR, Acerbi I, Weaver VM, Prekeris R, Tan AC, Schedin P. Collagen architecture in pregnancy-induced protection from breast cancer. Journal of Cell Science. 126: 4108-10. PMID 23843613 DOI: 10.1242/Jcs.121590  0.517
2013 Maller O, DuFort CC, Weaver VM. YAP forces fibroblasts to feel the tension. Nature Cell Biology. 15: 570-2. PMID 23728464 DOI: 10.1038/Ncb2777  0.441
2013 Tang Y, Rowe RG, Botvinick EL, Kurup A, Putnam AJ, Seiki M, Weaver VM, Keller ET, Goldstein S, Dai J, Begun D, Saunders T, Weiss SJ. MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis. Developmental Cell. 25: 402-16. PMID 23685250 DOI: 10.1016/J.Devcel.2013.04.011  0.371
2013 Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, ... ... Weaver VM, et al. A physical sciences network characterization of non-tumorigenic and metastatic cells. Scientific Reports. 3: 1449. PMID 23618955 DOI: 10.1038/Srep01449  0.7
2013 Li CR, Su JJ, Wang WY, Lee MT, Wang TY, Jiang KY, Li CF, Hsu JM, Chen CK, Chen M, Jiang SS, Weaver VM, Tsai KK. Molecular profiling of prostatic acinar morphogenesis identifies PDCD4 and KLF6 as tissue architecture-specific prognostic markers in prostate cancer. The American Journal of Pathology. 182: 363-74. PMID 23219426 DOI: 10.1016/J.Ajpath.2012.10.024  0.334
2013 Maller O, Hansen KC, Weaver V, Prekeris R, Schedin P. Abstract B090: Collagen organization implicated in tumor dormancy Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-B090  0.513
2013 Pickup MW, Owens P, Gorska A, Chytil A, Weaver V, Moses H. Abstract A16: Stromal LOX promotes TGFβR2 null breast cancer metastasis Cancer Research. 73. DOI: 10.1158/1538-7445.Tim2013-A16  0.504
2013 Barnes JM, Weaver VM. Abstract B04: The role of mechanical force and integrin-ECM signaling in glioblastoma aggression Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-B04  0.528
2013 Acerbi I, Hwang S, Munson J, Au A, Zheng S, Yu H, Mouw J, Lakins J, Swartz M, Shi Q, Liphardt J, Ruffell B, Coussen L, Yunn-Yi C, Weaver V. Abstract S2-06: Extracellular matrix stiffness modulates tissue inflammation to promote breast tumor aggression Cancer Research. 73. DOI: 10.1158/0008-5472.Sabcs13-S2-06  0.452
2012 Lakins JN, Chin AR, Weaver VM. Exploring the link between human embryonic stem cell organization and fate using tension-calibrated extracellular matrix functionalized polyacrylamide gels. Methods in Molecular Biology (Clifton, N.J.). 916: 317-50. PMID 22914951 DOI: 10.1007/978-1-61779-980-8_24  0.405
2012 Paszek MJ, DuFort CC, Rubashkin MG, Davidson MW, Thorn KS, Liphardt JT, Weaver VM. Scanning angle interference microscopy reveals cell dynamics at the nanoscale. Nature Methods. 9: 825-7. PMID 22751201 DOI: 10.1038/Nmeth.2077  0.672
2012 Cassereau L, DuFort CC, Weaver VM. Morphogenesis: Laying down the tracks. Nature Materials. 11: 490-2. PMID 22614514 DOI: 10.1038/Nmat3345  0.402
2012 Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. The Journal of Cell Biology. 196: 395-406. PMID 22351925 DOI: 10.1083/Jcb.201102147  0.609
2012 Laklai H, Kalluri R, Moses H, Weaver V, Ijichi H, Lakins J, Miroshnikova Y, Acerbi I, Lopez J, Kassianidou E, Gorska A, Novitskiy S. Abstract A47: Reciprocal dialogue between cellular and extracellular matrix tension and tissue inflammation in pancreatic tumor progression. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A47  0.487
2012 Weaver VM. Abstract SY28-03: The dynamic interplay between extrinsic and intrinsic force regulates cancer progression Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy28-03  0.537
2012 Yui Y, Mouw J, Yu H, Paszek MM, Lakins J, Weaver V. Abstract LB-494: Forcing integrin signaling perturbs mammary morphogenesis Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-494  0.47
2012 Pickup M, Chytil A, Gorska A, Aakre M, Weaver V, Moses H. Abstract 2456: TGF-Beta regulates tumor ECM remodeling and progression to metastasis Cancer Research. 72: 2456-2456. DOI: 10.1158/1538-7445.Am2012-2456  0.468
2012 Yu H, Yui Y, Weaver V. Abstract 1477: Tumor metastasis is modulated by tissue stiffness in MMTV-PyMT breast cancer model Cancer Research. 72: 1477-1477. DOI: 10.1158/1538-7445.Am2012-1477  0.51
2012 Acerbi I, Zheng S, Ruffell B, Au A, Shi Q, Liphardt J, Coussens L, Chen Y, Hwang E, Weaver V. 377 Extra-cellular Matrix Stiffness and Immune Cells Infiltrate Are Associated With Breast Tumor Phenotype European Journal of Cancer. 48: S91. DOI: 10.1016/S0959-8049(12)71063-8  0.45
2012 Miroshnikova Y, Acerbi I, Ilkhanizadeh S, Paszek M, Persson A, Weaver V. 159 The Role of the Biophysical Properties of the Glycocalyx and Extracellular Matrix Tension in Enhancing Glioma Cell Invasion European Journal of Cancer. 48: S38-S39. DOI: 10.1016/S0959-8049(12)70859-6  0.712
2012 Zheng S, Acerbi I, Kuhn N, Au A, Park C, Weaver V. Ionizing Radiation Modifies Tissue Tension, Mechanosignaling, and Apoptosis in Human Breast International Journal of Radiation Oncology*Biology*Physics. 84: S669. DOI: 10.1016/J.Ijrobp.2012.07.1786  0.325
2011 Lu P, Takai K, Weaver VM, Werb Z. Extracellular matrix degradation and remodeling in development and disease. Cold Spring Harbor Perspectives in Biology. 3. PMID 21917992 DOI: 10.1101/Cshperspect.A005058  0.605
2011 Lopez JI, Kang I, You WK, McDonald DM, Weaver VM. In situ force mapping of mammary gland transformation. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 910-21. PMID 21842067 DOI: 10.1039/C1Ib00043H  0.511
2011 Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, Munro J, Schröder E, Zhou J, Brunton VG, Barker N, Clevers H, Sansom OJ, Anderson KI, Weaver VM, et al. Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell. 19: 776-91. PMID 21665151 DOI: 10.1016/J.Ccr.2011.05.008  0.457
2011 DuFort CC, Paszek MJ, Weaver VM. Balancing forces: architectural control of mechanotransduction. Nature Reviews. Molecular Cell Biology. 12: 308-19. PMID 21508987 DOI: 10.1038/Nrm3112  0.709
2011 Dvorak HF, Weaver VM, Tlsty TD, Bergers G. Tumor microenvironment and progression. Journal of Surgical Oncology. 103: 468-74. PMID 21480238 DOI: 10.1002/Jso.21709  0.421
2011 Miroshnikova YA, Jorgens DM, Spirio L, Auer M, Sarang-Sieminski AL, Weaver VM. Engineering strategies to recapitulate epithelial morphogenesis within synthetic three-dimensional extracellular matrix with tunable mechanical properties. Physical Biology. 8: 026013. PMID 21441648 DOI: 10.1088/1478-3975/8/2/026013  0.446
2011 Yu H, Mouw JK, Weaver VM. Forcing form and function: biomechanical regulation of tumor evolution. Trends in Cell Biology. 21: 47-56. PMID 20870407 DOI: 10.1016/J.Tcb.2010.08.015  0.507
2011 Miroshnikova YA, Acerbi I, Persson A, Paszek MJ, Weiss WA, Weaver VM. Abstract LB-96: Extrinsic and intrinsic force and GBM aggression Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-96  0.739
2011 Acerbi I, Alfred A, Lopez J, Hwang S, Weaver V. Abstract 416: Mammographic density and ECM stiffness Cancer Research. 71: 416-416. DOI: 10.1158/1538-7445.Am2011-416  0.414
2010 Frantz C, Stewart KM, Weaver VM. The extracellular matrix at a glance. Journal of Cell Science. 123: 4195-200. PMID 21123617 DOI: 10.1242/Jcs.023820  0.4
2010 Egeblad M, Rasch MG, Weaver VM. Dynamic interplay between the collagen scaffold and tumor evolution. Current Opinion in Cell Biology. 22: 697-706. PMID 20822891 DOI: 10.1016/J.Ceb.2010.08.015  0.488
2010 Brown XQ, Bartolak-Suki E, Williams C, Walker ML, Weaver VM, Wong JY. Effect of substrate stiffness and PDGF on the behavior of vascular smooth muscle cells: implications for atherosclerosis. Journal of Cellular Physiology. 225: 115-22. PMID 20648629 DOI: 10.1002/Jcp.22202  0.339
2010 Gilbert PM, Mouw JK, Unger MA, Lakins JN, Gbegnon MK, Clemmer VB, Benezra M, Licht JD, Boudreau NJ, Tsai KK, Welm AL, Feldman MD, Weber BL, Weaver VM. HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype. The Journal of Clinical Investigation. 120: 1535-50. PMID 20389018 DOI: 10.1172/Jci39534  0.734
2010 Cohet N, Stewart KM, Mudhasani R, Asirvatham AJ, Mallappa C, Imbalzano KM, Weaver VM, Imbalzano AN, Nickerson JA. SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells. Journal of Cellular Physiology. 223: 667-78. PMID 20333683 DOI: 10.1002/Jcp.22072  0.458
2010 Paszek M, Weaver V. Enforcing order on signaling Science. 327: 1335-1336. PMID 20223974 DOI: 10.1126/Science.1187865  0.679
2010 Su JJ-, Li C, Lee MT-, Chu PYW, Weaver VM, Tsai KK-. A gene expression signature associated with structural differentiation of prostate acini predicts postoperative recurrence of prostate cancer Clinical Cancer Research. 16. DOI: 10.1158/Diag-10-A22  0.304
2010 Yu H, Weaver VM. Abstract LB-198: Collagen remodeling and tissue mechanics at different stages of mammary tumor development Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-Lb-198  0.386
2009 Paszek MJ, Boettiger D, Weaver VM, Hammer DA. Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate. Plos Computational Biology. 5: e1000604. PMID 20011123 DOI: 10.1371/Journal.Pcbi.1000604  0.73
2009 Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 139: 891-906. PMID 19931152 DOI: 10.1016/J.Cell.2009.10.027  0.738
2009 Hansma P, Yu H, Schultz D, Rodriguez A, Yurtsev EA, Orr J, Tang S, Miller J, Wallace J, Zok F, Li C, Souza R, Proctor A, Brimer D, Nogues-Solan X, ... ... Weaver V, et al. The tissue diagnostic instrument. The Review of Scientific Instruments. 80: 054303. PMID 19485522 DOI: 10.1063/1.3127602  0.359
2009 Gehler S, Baldassarre M, Lad Y, Leight JL, Wozniak MA, Riching KM, Eliceiri KW, Weaver VM, Calderwood DA, Keely PJ. Filamin A-beta1 integrin complex tunes epithelial cell response to matrix tension. Molecular Biology of the Cell. 20: 3224-38. PMID 19458194 DOI: 10.1091/Mbc.E08-12-1186  0.415
2009 Engler AJ, Humbert PO, Wehrle-Haller B, Weaver VM. Multiscale modeling of form and function. Science (New York, N.Y.). 324: 208-12. PMID 19359578 DOI: 10.1126/Science.1170107  0.421
2009 Vasilatos SN, Broadwater G, Barry WT, Baker JC, Lem S, Dietze EC, Bean GR, Bryson AD, Pilie PG, Goldenberg V, Skaar D, Paisie C, Torres-Hernandez A, Grant TL, Wilke LG, ... ... Weaver VM, et al. CpG island tumor suppressor promoter methylation in non-BRCA-associated early mammary carcinogenesis. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 18: 901-14. PMID 19258476 DOI: 10.1158/1055-9965.Epi-08-0875  0.367
2009 Butcher DT, Alliston T, Weaver VM. A tense situation: forcing tumour progression. Nature Reviews. Cancer. 9: 108-22. PMID 19165226 DOI: 10.1038/Nrc2544  0.378
2009 Kumar S, Weaver VM. Mechanics, malignancy, and metastasis: the force journey of a tumor cell. Cancer Metastasis Reviews. 28: 113-27. PMID 19153673 DOI: 10.1007/S10555-008-9173-4  0.503
2009 Erler JT, Weaver VM. Three-dimensional context regulation of metastasis. Clinical & Experimental Metastasis. 26: 35-49. PMID 18814043 DOI: 10.1007/S10585-008-9209-8  0.481
2008 Lopez JI, Mouw JK, Weaver VM. Biomechanical regulation of cell orientation and fate Oncogene. 27: 6981-6993. PMID 19029939 DOI: 10.1038/Onc.2008.348  0.498
2008 Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, et al. A human breast cell model of preinvasive to invasive transition. Cancer Research. 68: 1378-87. PMID 18316601 DOI: 10.1158/0008-5472.Can-07-2225  0.809
2008 Yee KL, Weaver VM, Hammer DA. Integrin-mediated signalling through the MAP-kinase pathway. Iet Systems Biology. 2: 8-15. PMID 18248081 DOI: 10.1049/Iet-Syb:20060058  0.524
2008 Fournier AK, Campbell LE, Castagnino P, Liu WF, Chung BM, Weaver VM, Chen CS, Assoian RK. Rac-dependent cyclin D1 gene expression regulated by cadherin- and integrin-mediated adhesion. Journal of Cell Science. 121: 226-33. PMID 18187454 DOI: 10.1242/Jcs.017012  0.379
2008 Hebner C, Weaver VM, Debnath J. Modeling morphogenesis and oncogenesis in three-dimensional breast epithelial cultures. Annual Review of Pathology. 3: 313-39. PMID 18039125 DOI: 10.1146/Annurev.Pathmechdis.3.121806.151526  0.402
2007 Weaver V, Werb Z. G'rab'bing the microenvironment for invasion. Developmental Cell. 13: 462-3. PMID 17925222 DOI: 10.1016/J.Devcel.2007.09.013  0.597
2007 Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NF-kappaB-dependent resistance to apoptosis in 3D mammary acini. Journal of Cell Science. 120: 3700-12. PMID 17911169 DOI: 10.1242/Jcs.03484  0.805
2007 Kass L, Erler JT, Dembo M, Weaver VM. Mammary epithelial cell: influence of extracellular matrix composition and organization during development and tumorigenesis. The International Journal of Biochemistry & Cell Biology. 39: 1987-94. PMID 17719831 DOI: 10.1016/J.Biocel.2007.06.025  0.507
2007 Johnson KR, Leight JL, Weaver VM. Demystifying the effects of a three-dimensional microenvironment in tissue morphogenesis. Methods in Cell Biology. 83: 547-83. PMID 17613324 DOI: 10.1016/S0091-679X(07)83023-8  0.429
2006 Boudreau N, Weaver V. Forcing the Third Dimension Cell. 125: 429-431. PMID 16678088 DOI: 10.1016/J.Cell.2006.04.019  0.384
2006 Underwood JM, Imbalzano KM, Weaver VM, Fischer AH, Imbalzano AN, Nickerson JA. The ultrastructure of MCF-10A acini. Journal of Cellular Physiology. 208: 141-8. PMID 16607610 DOI: 10.1002/Jcp.20639  0.378
2005 Yan Y, Weaver VM, Blair IA. Analysis of protein expression during oxidative stress in breast epithelial cells using a stable isotope labeled proteome internal standard. Journal of Proteome Research. 4: 2007-14. PMID 16335945 DOI: 10.1021/Pr050175D  0.386
2005 Paszek MJ, Zahir N, Johnson KR, Lakins JN, Rozenberg GI, Gefen A, Reinhart-King CA, Margulies SS, Dembo M, Boettiger D, Hammer DA, Weaver VM. Tensional homeostasis and the malignant phenotype. Cancer Cell. 8: 241-54. PMID 16169468 DOI: 10.1016/J.Ccr.2005.08.010  0.817
2005 Yang C, Liu Y, Leskow FC, Weaver VM, Kazanietz MG. Rac-GAP-dependent inhibition of breast cancer cell proliferation by {beta}2-chimerin. The Journal of Biological Chemistry. 280: 24363-70. PMID 15863513 DOI: 10.1074/Jbc.M411629200  0.4
2005 Cowden Dahl KD, Robertson SE, Weaver VM, Simon MC. Hypoxia-inducible factor regulates alphavbeta3 integrin cell surface expression. Molecular Biology of the Cell. 16: 1901-12. PMID 15689487 DOI: 10.1091/Mbc.E04-12-1082  0.441
2005 Yeung T, Georges PC, Flanagan LA, Marg B, Ortiz M, Funaki M, Zahir N, Ming W, Weaver V, Janmey PA. Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion. Cell Motility and the Cytoskeleton. 60: 24-34. PMID 15573414 DOI: 10.1002/Cm.20041  0.796
2004 Paszek MJ, Weaver VM. The tension mounts: mechanics meets morphogenesis and malignancy. Journal of Mammary Gland Biology and Neoplasia. 9: 325-42. PMID 15838603 DOI: 10.1007/S10911-004-1404-X  0.742
2004 Zahir N, Weaver VM. Death in the third dimension: apoptosis regulation and tissue architecture. Current Opinion in Genetics & Development. 14: 71-80. PMID 15108808 DOI: 10.1016/J.Gde.2003.12.005  0.817
2004 Weaver VM, Gilbert P. Watch thy neighbor: cancer is a communal affair. Journal of Cell Science. 117: 1287-90. PMID 15020668 DOI: 10.1242/Jcs.01137  0.748
2003 Zahir N, Lakins JN, Russell A, Ming W, Chatterjee C, Rozenberg GI, Marinkovich MP, Weaver VM. Autocrine laminin-5 ligates alpha6beta4 integrin and activates RAC and NFkappaB to mediate anchorage-independent survival of mammary tumors. The Journal of Cell Biology. 163: 1397-407. PMID 14691145 DOI: 10.1083/Jcb.200302023  0.807
2003 Russell AJ, Fincher EF, Millman L, Smith R, Vela V, Waterman EA, Dey CN, Guide S, Weaver VM, Marinkovich MP. Alpha 6 beta 4 integrin regulates keratinocyte chemotaxis through differential GTPase activation and antagonism of alpha 3 beta 1 integrin. Journal of Cell Science. 116: 3543-56. PMID 12865436 DOI: 10.1242/Jcs.00663  0.305
2003 Unger M, Weaver VM. The tissue microenvironment as an epigenetic tumor modifier. Methods in Molecular Biology (Clifton, N.J.). 223: 315-47. PMID 12777739 DOI: 10.1385/1-59259-329-1:315  0.449
2002 Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: Microenvironmental influences in the normal and malignant breast Differentiation. 70: 537-546. PMID 12492495 DOI: 10.1046/J.1432-0436.2002.700907.X  0.631
2002 Weaver VM, Lelièvre S, Lakins JN, Chrenek MA, Jones JCR, Giancotti F, Werb Z, Bissell MJ. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium Cancer Cell. 2: 205-216. PMID 12242153 DOI: 10.1016/S1535-6108(02)00125-3  0.769
2002 Weaver VM. Membrane-associated MMP regulators: novel cell adhesion tumor suppressor proteins? Developmental Cell. 2: 6-7. PMID 11782309 DOI: 10.1016/S1534-5807(01)00117-4  0.432
2001 Chrenek MA, Wong P, Weaver VM. Integrins and cell adhesions as modulators of mammary cell survival and transformation Breast Cancer Research. 3: 224-229. PMID 11434873 DOI: 10.1186/Bcr300  0.507
2000 Gray J, Chin K, Collins C, Yaswin P, Nonet G, Kowbel D, Kuo W, Garcia E, Solorzano COd, Knowles D, Lockett S, Bissell M, Weaver V, Pinkel D, Albertson D, et al. Two molecular cytogenetic views of breast cancer Breast Cancer Research. 2: 1-2. DOI: 10.1186/Bcr195  0.512
1999 Guerra-Vladusic FK, Scott G, Weaver V, Vladusic EA, Tsai MS, Benz CC, Lupu R. Constitutive expression of Heregulin induces apoptosis in an erbB-2 overexpressing breast cancer cell line SKBr-3. International Journal of Oncology. 15: 883-92. PMID 10536169 DOI: 10.3892/Ijo.15.5.883  0.425
1999 Weaver VM, Bissell MJ. Functional Culture Models to Study Mechanisms Governing Apoptosis in Normal and Malignant Mammary Epithelial Cells Journal of Mammary Gland Biology and Neoplasia. 4: 193-201. PMID 10426398 DOI: 10.1023/A:1018781325716  0.631
1998 Schmeichel KL, Weaver VM, Bissell MJ. Structural Cues from the Tissue Microenvironment Are Essential Determinants of the Human Mammary Epithelial Cell Phenotype Journal of Mammary Gland Biology and Neoplasia. 3: 201-213. PMID 10819528 DOI: 10.1023/A:1018751124382  0.599
1998 Wang F, Weaver VM, Petersen OW, Larabell CA, Dedhar S, Briand P, Lupu R, Bissell MJ. Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. Proceedings of the National Academy of Sciences of the United States of America. 95: 14821-6. PMID 9843973 DOI: 10.1073/Pnas.95.25.14821  0.618
1998 Lelièvre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ. Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus Proceedings of the National Academy of Sciences of the United States of America. 95: 14711-14716. PMID 9843954 DOI: 10.1073/Pnas.95.25.14711  0.752
1998 Petersen OW, Ronnov-Jessen L, Weaver VM, Bissell MJ. Differentiation and cancer in the mammary gland: Shedding light on an old dichotomy Advances in Cancer Research. 75: 135-161. PMID 9709809 DOI: 10.1016/S0065-230X(08)60741-1  0.594
1997 Weaver VM, Petersen OW, Wang F, Larabell CA, Briand P, Damsky C, Bissell MJ. Reversion of the malignant phenotype of human breast cells in three- dimensional culture and in vivo by integrin blocking antibodies Journal of Cell Biology. 137: 231-245. PMID 9105051 DOI: 10.1083/Jcb.137.1.231  0.61
1997 Lelièvre S, Weaver VM, Larabell CA, Bissell MJ. Extracellular Matrix and Nuclear Matrix Interactions May Regulate Apoptosis and Tissue-Specific Gene Expression: A Concept Whose Time has Come Advances in Molecular and Cell Biology. 24: 1-55. DOI: 10.1016/S1569-2558(08)60211-8  0.762
1997 Weaver VM, Roskelley CD. Extracellular matrix: The central regulator of cell and tissue homeostasis Trends in Cell Biology. 7: 40-42. DOI: 10.1016/S0962-8924(97)30078-6  0.495
1996 Weaver VM, Fischer AH, Peterson OW, Bissell MJ. The importance of the microenvironment in breast cancer progression: Recapitulation of mammary tumorigenesis using a unique human mammary epithelial cell model and a three-dimensional culture assay Biochemistry and Cell Biology. 74: 833-851. PMID 9164652 DOI: 10.1139/O96-089  0.658
1995 Weaver VM, Howlett AR, Langton-Webster B, Petersen OW, Bissell MJ. The development of a functionally relevant cell culture model of progressive human breast cancer Seminars in Cancer Biology. 6: 175-184. PMID 7495986 DOI: 10.1006/Scbi.1995.0021  0.628
1993 Weaver VM, Welsh J. 1,25-Dihydroxycholecalciferol supplementation prevents hypocalcemia in magnesium-deficient chicks Journal of Nutrition. 123: 764-771. PMID 8463878 DOI: 10.1093/Jn/123.4.764  0.548
1991 Welsh J, Weaver V, Simboli-Campbell M. Regulation of renal 25(OH)D3 1 alpha-hydroxylase: signal transduction pathways Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 69: 768-770. PMID 1667975 DOI: 10.1139/O91-118  0.591
1989 Weaver VM, Welsh JJ. Vitamin D metabolism in magnesium deficient chicks Nutrition Research. 9: 1363-1369. DOI: 10.1016/S0271-5317(89)80161-7  0.549
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