| Year |
Citation |
Score |
| 2020 |
Zhang JQ, Bosbach B, Loo JK, Vitiello GA, Zeng S, Seifert AM, Medina BD, Param NJ, Maltbaek JH, Rossi F, Antonescu CR, Besmer P, DeMatteo RP. The V654A second-site KIT mutation increases tumor oncogenesis and STAT activation in a mouse model of gastrointestinal stromal tumor. Oncogene. PMID 33024275 DOI: 10.1038/s41388-020-01489-4 |
0.388 |
|
| 2017 |
Bosbach B, Rossi F, Yozgat Y, Loo J, Zhang JQ, Berrozpe G, Warpinski K, Ehlers I, Veach D, Kwok A, Manova K, Antonescu CR, DeMatteo RP, Besmer P. Direct engagement of the PI3K pathway by mutant KIT dominates oncogenic signaling in gastrointestinal stromal tumor. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923937 DOI: 10.1073/Pnas.1711449114 |
0.392 |
|
| 2016 |
Buono M, Facchini R, Matsuoka S, Thongjuea S, Waithe D, Luis TC, Giustacchini A, Besmer P, Mead AJ, Jacobsen SE, Nerlov C. A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors. Nature Cell Biology. 18: 157-67. PMID 26780297 DOI: 10.1038/Ncb3299 |
0.383 |
|
| 2015 |
Cohen NA, Zeng S, Seifert AM, Kim TS, Sorenson EC, Greer JB, Beckman MJ, Santamaria-Barria JA, Crawley MH, Green BL, Rossi F, Besmer P, Antonescu CR, DeMatteo RP. Pharmacological Inhibition of KIT Activates MET Signaling in Gastrointestinal Stromal Tumors. Cancer Research. 75: 2061-70. PMID 25836719 DOI: 10.1158/0008-5472.CAN-14-2564 |
0.307 |
|
| 2015 |
Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, Xie Y, Kaufmann MC, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, ... Besmer P, et al. Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Cancer Discovery. 5: 304-15. PMID 25572173 DOI: 10.1158/2159-8290.Cd-14-0985 |
0.336 |
|
| 2014 |
Kim TS, Cavnar MJ, Cohen NA, Sorenson EC, Greer JB, Seifert AM, Crawley MH, Green BL, Popow R, Pillarsetty N, Veach DR, Ku AT, Rossi F, Besmer P, Antonescu CR, et al. Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 2350-62. PMID 24583793 DOI: 10.1158/1078-0432.Ccr-13-3033 |
0.366 |
|
| 2013 |
Deshpande S, Bosbach B, Yozgat Y, Park CY, Moore MA, Besmer P. KIT receptor gain-of-function in hematopoiesis enhances stem cell self-renewal and promotes progenitor cell expansion. Stem Cells (Dayton, Ohio). 31: 1683-95. PMID 23681919 DOI: 10.1002/Stem.1419 |
0.378 |
|
| 2012 |
Italiano A, Chen CL, Sung YS, Singer S, DeMatteo RP, LaQuaglia MP, Besmer P, Socci N, Antonescu CR. SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors. Bmc Cancer. 12: 408. PMID 22974104 DOI: 10.1186/1471-2407-12-408 |
0.388 |
|
| 2012 |
Bosbach B, Deshpande S, Rossi F, Shieh JH, Sommer G, de Stanchina E, Veach DR, Scandura JM, Manova-Todorova K, Moore MA, Antonescu CR, Besmer P. Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor. Proceedings of the National Academy of Sciences of the United States of America. 109: E2276-83. PMID 22652566 DOI: 10.1073/Pnas.1115240109 |
0.465 |
|
| 2012 |
Chen J, Guo T, Zhang L, Qin LX, Singer S, Maki RG, Taguchi T, Dematteo R, Besmer P, Antonescu CR. CD133 and CD44 are universally overexpressed in GIST and do not represent cancer stem cell markers. Genes, Chromosomes & Cancer. 51: 186-95. PMID 22076958 DOI: 10.1002/Gcc.20942 |
0.328 |
|
| 2011 |
Balachandran VP, Cavnar MJ, Zeng S, Bamboat ZM, Ocuin LM, Obaid H, Sorenson EC, Popow R, Ariyan C, Rossi F, Besmer P, Guo T, Antonescu CR, Taguchi T, Yuan J, et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nature Medicine. 17: 1094-100. PMID 21873989 DOI: 10.1038/Nm.2438 |
0.312 |
|
| 2010 |
Deshpande S, Agosti V, Manova K, Moore MA, Hardy MP, Besmer P. Kit ligand cytoplasmic domain is essential for basolateral sorting in vivo and has roles in spermatogenesis and hematopoiesis. Developmental Biology. 337: 199-210. PMID 19874813 DOI: 10.1016/J.Ydbio.2009.10.022 |
0.492 |
|
| 2009 |
Guo T, Hajdu M, Agaram NP, Shinoda H, Veach D, Clarkson BD, Maki RG, Singer S, Dematteo RP, Besmer P, Antonescu CR. Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: an in vitro mutagenesis screen for drug resistance. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6862-70. PMID 19861442 DOI: 10.1158/1078-0432.Ccr-09-1315 |
0.392 |
|
| 2009 |
John GB, Shidler MJ, Besmer P, Castrillon DH. Kit signaling via PI3K promotes ovarian follicle maturation but is dispensable for primordial follicle activation. Developmental Biology. 331: 292-9. PMID 19447101 DOI: 10.1016/j.ydbio.2009.05.546 |
0.32 |
|
| 2009 |
Agosti V, Karur V, Sathyanarayana P, Besmer P, Wojchowski DM. A KIT juxtamembrane PY567 -directed pathway provides nonredundant signals for erythroid progenitor cell development and stress erythropoiesis. Experimental Hematology. 37: 159-71. PMID 19100679 DOI: 10.1016/J.Exphem.2008.10.009 |
0.394 |
|
| 2009 |
Kwon JG, Hwang SJ, Hennig GW, Bayguinov Y, McCann C, Chen H, Rossi F, Besmer P, Sanders KM, Ward SM. Changes in the structure and function of ICC networks in ICC hyperplasia and gastrointestinal stromal tumors. Gastroenterology. 136: 630-9. PMID 19032955 DOI: 10.1053/J.Gastro.2008.10.031 |
0.459 |
|
| 2008 |
Agaram NP, Wong GC, Guo T, Maki RG, Singer S, Dematteo RP, Besmer P, Antonescu CR. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. Genes, Chromosomes & Cancer. 47: 853-9. PMID 18615679 DOI: 10.1002/Gcc.20589 |
0.425 |
|
| 2008 |
Agaram NP, Laquaglia MP, Ustun B, Guo T, Wong GC, Socci ND, Maki RG, DeMatteo RP, Besmer P, Antonescu CR. Molecular characterization of pediatric gastrointestinal stromal tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 3204-15. PMID 18483389 DOI: 10.1158/1078-0432.Ccr-07-1984 |
0.302 |
|
| 2008 |
Dematteo RP, Gold JS, Saran L, Gönen M, Liau KH, Maki RG, Singer S, Besmer P, Brennan MF, Antonescu CR. Tumor mitotic rate, size, and location independently predict recurrence after resection of primary gastrointestinal stromal tumor (GIST). Cancer. 112: 608-15. PMID 18076015 DOI: 10.1002/Cncr.23199 |
0.415 |
|
| 2007 |
Guo T, Agaram NP, Wong GC, Hom G, D'Adamo D, Maki RG, Schwartz GK, Veach D, Clarkson BD, Singer S, DeMatteo RP, Besmer P, Antonescu CR. Sorafenib inhibits the imatinib-resistant KITT670I gatekeeper mutation in gastrointestinal stromal tumor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 4874-81. PMID 17699867 DOI: 10.1158/1078-0432.Ccr-07-0484 |
0.423 |
|
| 2007 |
Antonescu CR, Busam KJ, Francone TD, Wong GC, Guo T, Agaram NP, Besmer P, Jungbluth A, Gimbel M, Chen CT, Veach D, Clarkson BD, Paty PB, Weiser MR. L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. International Journal of Cancer. 121: 257-64. PMID 17372901 DOI: 10.1002/Ijc.22681 |
0.35 |
|
| 2007 |
Agaram NP, Besmer P, Wong GC, Guo T, Socci ND, Maki RG, DeSantis D, Brennan MF, Singer S, DeMatteo RP, Antonescu CR. Pathologic and molecular heterogeneity in imatinib-stable or imatinib-responsive gastrointestinal stromal tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 170-81. PMID 17200352 DOI: 10.1158/1078-0432.Ccr-06-1508 |
0.413 |
|
| 2006 |
Agaram NP, Baren A, Arkun K, Dematteo RP, Besmer P, Antonescu CR. Comparative ultrastructural analysis and KIT/PDGFRA genotype in 125 gastrointestinal stromal tumors. Ultrastructural Pathology. 30: 443-52. PMID 17182437 DOI: 10.1080/01913120600854186 |
0.418 |
|
| 2006 |
Rossi F, Ehlers I, Agosti V, Socci ND, Viale A, Sommer G, Yozgat Y, Manova K, Antonescu CR, Besmer P. Oncogenic Kit signaling and therapeutic intervention in a mouse model of gastrointestinal stromal tumor. Proceedings of the National Academy of Sciences of the United States of America. 103: 12843-8. PMID 16908864 DOI: 10.1073/Pnas.0511076103 |
0.453 |
|
| 2006 |
Yu M, Luo J, Yang W, Wang Y, Mizuki M, Kanakura Y, Besmer P, Neel BG, Gu H. The scaffolding adapter Gab2, via Shp-2, regulates kit-evoked mast cell proliferation by activating the Rac/JNK pathway. The Journal of Biological Chemistry. 281: 28615-26. PMID 16873377 DOI: 10.1074/Jbc.M603742200 |
0.509 |
|
| 2006 |
Berrozpe G, Agosti V, Tucker C, Blanpain C, Manova K, Besmer P. A distant upstream locus control region is critical for expression of the Kit receptor gene in mast cells. Molecular and Cellular Biology. 26: 5850-60. PMID 16847336 DOI: 10.1128/Mcb.01854-05 |
0.45 |
|
| 2006 |
Karur VG, Lowell CA, Besmer P, Agosti V, Wojchowski DM. Lyn kinase promotes erythroblast expansion and late-stage development. Blood. 108: 1524-32. PMID 16705093 DOI: 10.1182/Blood-2005-09-008243 |
0.436 |
|
| 2005 |
Cammenga J, Horn S, Bergholz U, Sommer G, Besmer P, Fiedler W, Stocking C. Extracellular KIT receptor mutants, commonly found in core binding factor AML, are constitutively active and respond to imatinib mesylate. Blood. 106: 3958-61. PMID 16081693 DOI: 10.1182/Blood-2005-02-0583 |
0.465 |
|
| 2005 |
Antonescu CR, Besmer P, Guo T, Arkun K, Hom G, Koryotowski B, Leversha MA, Jeffrey PD, Desantis D, Singer S, Brennan MF, Maki RG, DeMatteo RP. Acquired resistance to imatinib in gastrointestinal stromal tumor occurs through secondary gene mutation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 4182-90. PMID 15930355 DOI: 10.1158/1078-0432.Ccr-04-2245 |
0.39 |
|
| 2005 |
Prakash S, Sarran L, Socci N, DeMatteo RP, Eisenstat J, Greco AM, Maki RG, Wexler LH, LaQuaglia MP, Besmer P, Antonescu CR. Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. Journal of Pediatric Hematology/Oncology. 27: 179-87. PMID 15838387 DOI: 10.1097/01.Mph.0000157790.81329.47 |
0.313 |
|
| 2005 |
Yantiss RK, Rosenberg AE, Sarran L, Besmer P, Antonescu CR. Multiple gastrointestinal stromal tumors in type I neurofibromatosis: a pathologic and molecular study. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 18: 475-84. PMID 15540118 DOI: 10.1038/Modpathol.3800334 |
0.372 |
|
| 2004 |
Antonescu CR, Viale A, Sarran L, Tschernyavsky SJ, Gonen M, Segal NH, Maki RG, Socci ND, DeMatteo RP, Besmer P. Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 3282-90. PMID 15161681 DOI: 10.1158/1078-0432.Ccr-03-0715 |
0.376 |
|
| 2004 |
Agosti V, Corbacioglu S, Ehlers I, Waskow C, Sommer G, Berrozpe G, Kissel H, Tucker CM, Manova K, Moore MA, Rodewald HR, Besmer P. Critical role for Kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development. The Journal of Experimental Medicine. 199: 867-78. PMID 15024050 DOI: 10.1084/Jem.20031983 |
0.493 |
|
| 2004 |
Robson ME, Glogowski E, Sommer G, Antonescu CR, Nafa K, Maki RG, Ellis N, Besmer P, Brennan M, Offit K. Pleomorphic characteristics of a germ-line KIT mutation in a large kindred with gastrointestinal stromal tumors, hyperpigmentation, and dysphagia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1250-4. PMID 14977822 DOI: 10.1158/1078-0432.Ccr-03-0110 |
0.411 |
|
| 2003 |
Rothschild G, Sottas CM, Kissel H, Agosti V, Manova K, Hardy MP, Besmer P. A role for kit receptor signaling in Leydig cell steroidogenesis. Biology of Reproduction. 69: 925-32. PMID 12773427 DOI: 10.1095/Biolreprod.102.014548 |
0.693 |
|
| 2003 |
Sommer G, Agosti V, Ehlers I, Rossi F, Corbacioglu S, Farkas J, Moore M, Manova K, Antonescu CR, Besmer P. Gastrointestinal stromal tumors in a mouse model by targeted mutation of the Kit receptor tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America. 100: 6706-11. PMID 12754375 DOI: 10.1073/Pnas.1037763100 |
0.508 |
|
| 2002 |
Heissig B, Hattori K, Dias S, Friedrich M, Ferris B, Hackett NR, Crystal RG, Besmer P, Lyden D, Moore MAS, Werb Z, Rafii S. Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of Kit-ligand Cell. 109: 625-637. PMID 12062105 DOI: 10.1016/S0092-8674(02)00754-7 |
0.34 |
|
| 2000 |
Kissel H, Timokhina I, Hardy MP, Rothschild G, Tajima Y, Soares V, Angeles M, Whitlow SR, Manova K, Besmer P. Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. The Embo Journal. 19: 1312-26. PMID 10716931 DOI: 10.1093/Emboj/19.6.1312 |
0.706 |
|
| 1999 |
Berrozpe G, Timokhina I, Yukl S, Tajima Y, Ono M, Zelenetz AD, Besmer P. The Wsh, W57, and Ph Kit expression mutations define tissue-specific control elements located between -23 and -154 kb upstream of Kit Blood. 94: 2658-2666. DOI: 10.1182/Blood.V94.8.2658.420K23_2658_2666 |
0.463 |
|
| 1998 |
Timokhina I, Kissel H, Stella G, Besmer P. Kit signaling through PI 3‐kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation The Embo Journal. 17: 6250-6262. PMID 9799234 DOI: 10.1093/Emboj/17.21.6250 |
0.458 |
|
| 1998 |
Tajima Y, Moore MAS, Soares V, Ono M, Kissel H, Besmer P. Consequences of exclusive expression in vivo of kit-ligand lacking the major proteolytic cleavage site Proceedings of the National Academy of Sciences of the United States of America. 95: 11903-11908. PMID 9751763 DOI: 10.1073/Pnas.95.20.11903 |
0.479 |
|
| 1995 |
Packer AI, Besmer P, Bachvarova RF. Kit ligand mediates survival of type A spermatogonia and dividing spermatocytes in postnatal mouse testes. Molecular Reproduction and Development. 42: 303-10. PMID 8579844 DOI: 10.1002/Mrd.1080420307 |
0.433 |
|
| 1995 |
Wu H, Klingmüller U, Besmer P, Lodish HF. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 377: 242-6. PMID 7545788 DOI: 10.1038/377242A0 |
0.501 |
|
| 1994 |
Packer AI, Hsu YC, Besmer P, Bachvarova RF. The ligand of the c-kit receptor promotes oocyte growth. Developmental Biology. 161: 194-205. PMID 7507447 DOI: 10.1006/Dbio.1994.1020 |
0.42 |
|
| 1993 |
Manova K, Huang EJ, Angeles M, De Leon V, Sanchez S, Pronovost SM, Besmer P, Bachvarova RF. The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia. Developmental Biology. 157: 85-99. PMID 7683286 DOI: 10.1006/Dbio.1993.1114 |
0.444 |
|
| 1993 |
Huang EJ, Manova K, Packer AI, Sanchez S, Bachvarova RF, Besmer P. The murine steel panda mutation affects kit ligand expression and growth of early ovarian follicles. Developmental Biology. 157: 100-9. PMID 7683280 DOI: 10.1006/Dbio.1993.1115 |
0.453 |
|
| 1993 |
Rassoulzadegan M, Paquis-Flucklinger V, Bertino B, Sage J, Jasin M, Miyagawa K, Heyningen Vv, Besmer P, Cuzin F. Transmeiotic differentiation of male germ cells in culture Cell. 75: 997-1006. PMID 7504588 DOI: 10.1016/0092-8674(93)90543-Y |
0.452 |
|
| 1993 |
Besmer P, Huang EJ, Manova K, Duttlinger R, Bachvarova RF. The Kit-Ligand (Steel Factor) and Its Receptor C-Kit. Insights from Germline Mutations. Experimental Animals. 9: 1-5. DOI: 10.1538/Expanim1992.9.1 |
0.398 |
|
| 1992 |
Huang EJ, Nocka KH, Buck J, Besmer P. Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Molecular Biology of the Cell. 3: 349-62. PMID 1378327 DOI: 10.1091/Mbc.3.3.349 |
0.46 |
|
| 1992 |
Murty VVVS, Houldsworth J, Baldwin S, Reuter V, Hunziker W, Besmer P, Bosl G, Chaganti RSK. Allelic deletions in the long arm of chromosome 12 identify sites of candidate tumor suppressor genes in male germ cell tumors Proceedings of the National Academy of Sciences of the United States of America. 89: 11006-11010. PMID 1332066 DOI: 10.1073/Pnas.89.22.11006 |
0.398 |
|
| 1992 |
Manova K, Bachvarova RF, Huang EJ, Sanchez S, Pronovost SM, Velazquez E, McGuire B, Besmer P. c-kit receptor and ligand expression in postnatal development of the mouse cerebellum suggests a function for c-kit in inhibitory interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4663-76. PMID 1281492 DOI: 10.1523/Jneurosci.12-12-04663.1992 |
0.444 |
|
| 1991 |
Besmer P. The kit ligand encoded at the murine Steel locus: a pleiotropic growth and differentiation factor. Current Opinion in Cell Biology. 3: 939-946. PMID 1726043 DOI: 10.1016/0955-0674(91)90111-B |
0.437 |
|
| 1990 |
Huang E, Nocka K, Beier DR, Chu TY, Buck J, Lahm HW, Wellner D, Leder P, Besmer P. The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell. 63: 225-33. PMID 1698557 DOI: 10.1016/0092-8674(90)90303-V |
0.425 |
|
| 1990 |
Tan JC, Nocka K, Ray P, Traktman P, Besmer P. The dominant W42 spotting phenotype results from a missense mutation in the c-kit receptor kinase. Science (New York, N.Y.). 247: 209-12. PMID 1688471 DOI: 10.1126/Science.1688471 |
0.489 |
|
| 1990 |
Nocka K, Tan J, Chiu E, Chu T, Ray P, Traktman P, Besmer P. Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W. The Embo Journal. 9: 1805-1813. DOI: 10.1002/J.1460-2075.1990.Tb08305.X |
0.483 |
|
| 1990 |
Nocka K, Buck J, Levi E, Besmer P. Candidate ligand for the c-kit transmembrane kinase receptor: KL, a fibroblast derived growth factor stimulates mast cells and erythroid progenitors. The Embo Journal. 9: 3287-3294. DOI: 10.1002/J.1460-2075.1990.Tb07528.X |
0.519 |
|
| 1979 |
Besmer P, Fan H, Paskind M, Baltimore D. Isolation and characterization of a mouse cell line containing a defective Moloney murine leukemia virus genome. Journal of Virology. 29: 1023-1034. PMID 221665 DOI: 10.1128/Jvi.29.3.1023-1034.1979 |
0.381 |
|
| 1978 |
Ruddle NH, Conta BS, Leinwand L, Kozak C, Ruddle F, Besmer P, Baltimore D. Assignment of the receptor for ecotropic murine leukemia virus to mouse chromosome 5 Journal of Experimental Medicine. 148: 451-465. PMID 212501 DOI: 10.1084/Jem.148.2.451 |
0.347 |
|
| 1977 |
Besmer P, Baltimore D. Mechanism of restriction of ecotropic and xenotropic murine leukemia viruses and formation of pseudotypes between the two viruses. Journal of Virology. 21: 965-973. PMID 191655 DOI: 10.1128/Jvi.21.3.965-973.1977 |
0.417 |
|
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