| Year |
Citation |
Score |
| 2024 |
Jee A, Christine Sernoskie S, Uetrecht J. The role of corticosterone in nevirapine-induced idiosyncratic drug-induced liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 38636494 DOI: 10.1093/toxsci/kfae054 |
0.425 |
|
| 2024 |
Sernoskie SC, Bonneil É, Thibault P, Jee A, Uetrecht J. . The Journal of Pharmacology and Experimental Therapeutics. PMID 38262745 DOI: 10.1124/jpet.123.001970 |
0.4 |
|
| 2024 |
Cho T, Wierk A, Gertsenstein M, Rodgers C, Uetrecht J, Henderson JT. The development and characterization of a CRISPR/Cas9-mediated PD-1 functional knockout rat as a tool to study idiosyncratic drug reactions. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 38230816 DOI: 10.1093/toxsci/kfae003 |
0.337 |
|
| 2023 |
Sernoskie SC, Jee A, Uetrecht J. The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis. International Journal of Molecular Sciences. 24. PMID 36674761 DOI: 10.3390/ijms24021243 |
0.36 |
|
| 2022 |
Uetrecht J. Idiosyncratic Drug Reactions: A 35-Year Perspective. Chemical Research in Toxicology. PMID 35687011 DOI: 10.1021/acs.chemrestox.2c00090 |
0.385 |
|
| 2022 |
Sernoskie SC, Lobach AR, Kato R, Jee A, Weston JK, Uetrecht J. Clozapine Induces an Acute Proinflammatory Response That Is Attenuated by Inhibition of Inflammasome Signaling: Implications for Idiosyncratic Drug-Induced Agranulocytosis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 186: 70-82. PMID 34935985 DOI: 10.1093/toxsci/kfab154 |
0.794 |
|
| 2021 |
Sernoskie SC, Jee A, Uetrecht JP. The Emerging Role of the Innate Immune Response in Idiosyncratic Drug Reactions. Pharmacological Reviews. 73: 861-896. PMID 34016669 DOI: 10.1124/pharmrev.120.000090 |
0.38 |
|
| 2021 |
Teschke R, Uetrecht J. Mechanism of idiosyncratic drug induced liver injury (DILI): unresolved basic issues. Annals of Translational Medicine. 9: 730. PMID 33987428 DOI: 10.21037/atm-2020-ubih-05 |
0.377 |
|
| 2021 |
Jee A, Sernoskie SC, Uetrecht J. Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges. International Journal of Molecular Sciences. 22. PMID 33799477 DOI: 10.3390/ijms22062954 |
0.412 |
|
| 2021 |
Cho T, Kok LY, Uetrecht J. Testing Possible Risk Factors for Idiosyncratic Drug-Induced Liver Injury Using an Amodiaquine Mouse Model and Co-treatment with 1-Methyl-d-Tryptophan or Acetaminophen. Acs Omega. 6: 4656-4662. PMID 33644572 DOI: 10.1021/acsomega.0c05352 |
0.391 |
|
| 2021 |
Cho T, Wang X, Yeung K, Cao Y, Uetrecht J. Liver Injury Caused by Green Tea Extract in PD-1 Mice: An Impaired Immune Tolerance Model for Idiosyncratic Drug-Induced Liver Injury. Chemical Research in Toxicology. PMID 33617238 DOI: 10.1021/acs.chemrestox.0c00485 |
0.346 |
|
| 2021 |
Cao Y, Bairam A, Jee A, Liu M, Uetrecht J. Investigating the Mechanism of Trimethoprim-Induced Skin Rash and Liver Injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 33394045 DOI: 10.1093/toxsci/kfaa182 |
0.313 |
|
| 2020 |
Kato R, Ijiri Y, Hayashi T, Uetrecht J. Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. The Journal of Toxicological Sciences. 45: 673-680. PMID 33132241 DOI: 10.2131/jts.45.673 |
0.311 |
|
| 2020 |
Regev A, Avigan MI, Kiazand A, Vierling JM, Lewis JH, Omokaro SO, Di Bisceglie AM, Fontana RJ, Bonkovsky HL, Freston JW, Uetrecht JP, Miller ED, Pehlivanov ND, Haque SA, Harrison MJ, et al. Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development. Journal of Autoimmunity. 102514. PMID 32768244 DOI: 10.1016/J.Jaut.2020.102514 |
0.422 |
|
| 2020 |
Uetrecht J. SC4.1 - The role of inflammatory mediators in idiosyncratic drug-induced liver injury Drug Metabolism and Pharmacokinetics. 35. DOI: 10.1016/J.Dmpk.2020.04.282 |
0.415 |
|
| 2020 |
Jee A, Uetrecht J. P121 - Early development of idiosyncratic drug-induced liver injury in an impaired immune checkpoint mouse model Drug Metabolism and Pharmacokinetics. 35. DOI: 10.1016/J.Dmpk.2020.04.122 |
0.439 |
|
| 2019 |
Cho T, Uetrecht J. Response to the Letter Concerning the Article "Rotenone Increases Isoniazid Toxicity but Does Not Cause Liver Injury: Implications for the Hypothesis that Inhibition of the Mitochondrial Electron Transport Chain is a Common Mechanism of Idiosyncratic Drug-Induced Liver Injury." By Bernard Fromenty. Chemical Research in Toxicology. PMID 31820941 DOI: 10.1021/Acs.Chemrestox.9B00436 |
0.377 |
|
| 2019 |
Uetrecht J. Mechanistic Studies of Idiosyncratic DILI: Clinical Implications. Frontiers in Pharmacology. 10: 837. PMID 31402866 DOI: 10.3389/Fphar.2019.00837 |
0.472 |
|
| 2019 |
Kato R, Ijiri Y, Hayashi T, Uetrecht J. The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 47: 1093-1096. PMID 31324698 DOI: 10.1124/dmd.119.087981 |
0.379 |
|
| 2019 |
Uetrecht J. Mechanisms of idiosyncratic drug-induced liver injury. Advances in Pharmacology (San Diego, Calif.). 85: 133-163. PMID 31307585 DOI: 10.1016/Bs.Apha.2018.12.001 |
0.512 |
|
| 2019 |
Cho T, Wang X, Uetrecht J. Rotenone Increases Isoniazid Toxicity but Does Not Cause Significant Liver Injury: Implications for the Hypothesis that Inhibition of the Mitochondrial Electron Transport Chain Is a Common Mechanism of Idiosyncratic Drug-Induced Liver Injury. Chemical Research in Toxicology. PMID 31251588 DOI: 10.1021/Acs.Chemrestox.9B00116 |
0.427 |
|
| 2019 |
Mak A, Uetrecht J. Involvement of CCL2/CCR2 macrophage recruitment in amodiaquine-induced liver injury. Journal of Immunotoxicology. 1-6. PMID 30663942 DOI: 10.1080/1547691X.2018.1516014 |
0.434 |
|
| 2019 |
Jee A, Uetrecht J. Characterising the immune response to carbamazepine: Understanding the development of idiosyncratic drug reactions Drug Metabolism and Pharmacokinetics. 34: S51-S52. DOI: 10.1016/J.Dmpk.2018.09.182 |
0.449 |
|
| 2019 |
Cao Y, Uetrecht J. Covalent binding of trimethoprim: Implications for trimethoprim-induced adverse reactions Drug Metabolism and Pharmacokinetics. 34: S20. DOI: 10.1016/J.Dmpk.2018.09.086 |
0.364 |
|
| 2019 |
Cho T, Wierk A, Henderson J, Uetrecht J. The development of a CRISPR/Cas-mediated PD-1 knockout rat model to study idiosyncratic drug reactions including nevirapine-induced liver injury Drug Metabolism and Pharmacokinetics. 34: S15-S16. DOI: 10.1016/J.Dmpk.2018.09.075 |
0.401 |
|
| 2018 |
Sharma A, Saito Y, Hung SI, Naisbitt D, Uetrecht J, Bussiere J. The skin as a metabolic and immune-competent organ: implications fordrug-induced skin rash. Journal of Immunotoxicology. 1-12. PMID 30318948 DOI: 10.1080/1547691X.2018.1514444 |
0.451 |
|
| 2018 |
Kenna JG, Uetrecht J. Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk? Drug Metabolism and Disposition: the Biological Fate of Chemicals. 46: 1658-1669. PMID 30021844 DOI: 10.1124/Dmd.118.082719 |
0.459 |
|
| 2018 |
Mak A, Cho TE, Uetrecht J. The Effects of Immune Modulators on Amodiaquine-Induced Liver Injury. Chemical Research in Toxicology. PMID 29938495 DOI: 10.1021/Acs.Chemrestox.8B00091 |
0.441 |
|
| 2018 |
Mak A, Cho T, Uetrecht J. Use of an animal model to test whether non-alcoholic fatty liver disease increases the risk of idiosyncratic drug-induced liver injury. Journal of Immunotoxicology. 15: 90-95. PMID 29733743 DOI: 10.1080/1547691X.2018.1467982 |
0.415 |
|
| 2018 |
Sastry J, Mohammed H, Campos MM, Uetrecht J, Abu-Asab M. Nevirapine-induced liver lipid-SER inclusions and other ultrastructural aberrations. Ultrastructural Pathology. 1-8. PMID 29424579 DOI: 10.1080/01913123.2017.1422831 |
0.433 |
|
| 2018 |
Uetrecht J. Making drugs great again: Eliminating idiosyncratic drug reactions Drug Metabolism and Pharmacokinetics. 33: S9. DOI: 10.1016/J.Dmpk.2017.11.041 |
0.399 |
|
| 2018 |
Uetrecht J. How reactive metabolites induce an immune response that sometimes leads to an idiosyncratic drug reaction Drug Metabolism and Pharmacokinetics. 33: S3. DOI: 10.1016/j.dmpk.2017.11.017 |
0.396 |
|
| 2017 |
Mak A, Uetrecht J. Immune mechanisms of idiosyncratic drug-induced liver injury. Journal of Clinical and Translational Research. 3: 145-156. PMID 30873473 |
0.401 |
|
| 2017 |
Mak A, Kato R, Weston K, Hayes A, Uetrecht J. An Impaired Immune Tolerance Animal Model Distinguishes the Potential of Troglitazone/Pioglitazone and Tolcapone/Entacapone to Cause IDILI. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29087505 DOI: 10.1093/Toxsci/Kfx219 |
0.472 |
|
| 2017 |
Kato R, Uetrecht J. Supernatant from Hepatocyte Cultures with Drugs That Cause Idiosyncratic Liver Injury Activates Macrophage Inflammasomes. Chemical Research in Toxicology. 30: 1327-1332. PMID 28525267 DOI: 10.1021/Acs.Chemrestox.7B00065 |
0.512 |
|
| 2017 |
Mak A, Johnston A, Uetrecht J. Effects of immunization and checkpoint inhibition on amodiaquine-induced liver injury. Journal of Immunotoxicology. 14: 89-94. PMID 28279082 DOI: 10.1080/1547691X.2017.1290716 |
0.451 |
|
| 2017 |
Mak A, Johnston A, Uetrecht J. The Effects of Immunization and Checkpoint Inhibition on Amodiaquine-Induced Liver Injury Journal of Pharmacological and Toxicological Methods. 88: 173. DOI: 10.1016/J.Vascn.2017.09.020 |
0.384 |
|
| 2016 |
Cho TE, Uetrecht J. How Reactive Metabolites Induce an Immune Response that Sometimes Leads to an Idiosyncratic Drug Reaction. Chemical Research in Toxicology. PMID 27775332 DOI: 10.1016/J.Dmpk.2017.11.017 |
0.526 |
|
| 2016 |
Liu F, Cai P, Metushi I, Li J, Nakayawa T, Vega L, Uetrecht J. Exploring an animal model of amodiaquine-induced liver injury in rats and mice. Journal of Immunotoxicology. 1-19. PMID 27416278 DOI: 10.3109/1547691X.2016.1166167 |
0.416 |
|
| 2016 |
Koen YM, Galeva NA, Metushi IG, Uetrecht J, Hanzlik RP. Protein targets of isoniazid reactive metabolites in mouse liver in vivo. Chemical Research in Toxicology. PMID 27097313 DOI: 10.1021/Acs.Chemrestox.6B00098 |
0.32 |
|
| 2016 |
Metushi I, Uetrecht J, Phillips E. Mechanism of isoniazid-induced hepatotoxicity: then and now. British Journal of Clinical Pharmacology. 81: 1030-6. PMID 26773235 DOI: 10.1111/Bcp.12885 |
0.456 |
|
| 2015 |
Mak A, Uetrecht J. The Combination of Anti-CTLA-4 and PD1-/- Mice Unmasks the Potential of Isoniazid and Nevirapine to Cause Liver Injury Chemical Research in Toxicology. 28: 2287-2291. PMID 26529122 DOI: 10.1021/Acs.Chemrestox.5B00305 |
0.455 |
|
| 2015 |
Mak A, Uetrecht J. The Role of CD8 T Cells in Amodiaquine-Induced Liver Injury in PD1-/- Mice Cotreated with Anti-CTLA-4 Chemical Research in Toxicology. 28: 1567-1573. PMID 26154582 DOI: 10.1021/Acs.Chemrestox.5B00137 |
0.426 |
|
| 2015 |
Uetrecht J, Kaplowitz N. Inhibition of immune tolerance unmasks drug-induced allergic hepatitis. Hepatology (Baltimore, Md.). 62: 346-8. PMID 25833746 DOI: 10.1002/Hep.27824 |
0.452 |
|
| 2015 |
Mak A, Uetrecht J. Immunization with amodiaquine-modified hepatic proteins prevents amodiaquine-induced liver injury Journal of Immunotoxicology. 12: 361-367. PMID 25425471 DOI: 10.3109/1547691X.2014.983660 |
0.475 |
|
| 2015 |
Johnston A, Uetrecht J. Current understanding of the mechanisms of idiosyncratic drug-induced agranulocytosis. Expert Opinion On Drug Metabolism & Toxicology. 11: 243-57. PMID 25424130 DOI: 10.1517/17425255.2015.985649 |
0.444 |
|
| 2015 |
Metushi IG, Hayes MA, Uetrecht J. Treatment of PD-1(-/-) mice with amodiaquine and anti-CTLA4 leads to liver injury similar to idiosyncratic liver injury in patients. Hepatology (Baltimore, Md.). 61: 1332-42. PMID 25283142 DOI: 10.1002/Hep.27549 |
0.409 |
|
| 2015 |
Metushi IG, Cai P, Dervovic D, Liu F, Lobach A, Nakagawa T, Uetrecht J. Development of a novel mouse model of amodiaquine-induced liver injury with a delayed onset. Journal of Immunotoxicology. 12: 247-60. PMID 25046026 DOI: 10.3109/1547691X.2014.934977 |
0.79 |
|
| 2014 |
Lobach AR, Uetrecht J. Clozapine promotes the proliferation of granulocyte progenitors in the bone marrow leading to increased granulopoiesis and neutrophilia in rats. Chemical Research in Toxicology. 27: 1109-19. PMID 24968143 DOI: 10.1021/Tx500184C |
0.752 |
|
| 2014 |
Ng W, Kennar R, Uetrecht J. Effect of clozapine and olanzapine on neutrophil kinetics: implications for drug-induced agranulocytosis. Chemical Research in Toxicology. 27: 1104-8. PMID 24968069 DOI: 10.1021/Tx500183X |
0.451 |
|
| 2014 |
Weston JK, Uetrecht J. Activation of inflammasomes by agents causing idiosyncratic skin reactions: a possible biomarker. Chemical Research in Toxicology. 27: 949-51. PMID 24877608 DOI: 10.1021/Tx5001333 |
0.472 |
|
| 2014 |
Metushi IG, Lee WM, Uetrecht J. IgG3 is the dominant subtype of anti-isoniazid antibodies in patients with isoniazid-induced liver failure. Chemical Research in Toxicology. 27: 738-40. PMID 24786179 DOI: 10.1021/Tx500108U |
0.355 |
|
| 2014 |
Metushi IG, Zhu X, Uetrecht J. D-penicillamine-induced granulomatous hepatitis in brown Norway rats. Molecular and Cellular Biochemistry. 393: 229-35. PMID 24771069 DOI: 10.1007/S11010-014-2065-8 |
0.413 |
|
| 2014 |
Shuhendler AJ, Pu K, Cui L, Uetrecht JP, Rao J. Real-time imaging of oxidative and nitrosative stress in the liver of live animals for drug-toxicity testing. Nature Biotechnology. 32: 373-80. PMID 24658645 DOI: 10.1038/Nbt.2838 |
0.41 |
|
| 2014 |
Metushi IG, Cai P, Vega L, Grant DM, Uetrecht J. Paradoxical attenuation of autoimmune hepatitis by oral isoniazid in wild-type and N-acetyltransferase-deficient mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 963-73. PMID 24623063 DOI: 10.1124/Dmd.113.056622 |
0.421 |
|
| 2014 |
Lobach AR, Uetrecht J. Involvement of myeloperoxidase and NADPH oxidase in the covalent binding of amodiaquine and clozapine to neutrophils: implications for drug-induced agranulocytosis. Chemical Research in Toxicology. 27: 699-709. PMID 24588327 DOI: 10.1021/Tx500019U |
0.762 |
|
| 2014 |
Metushi IG, Zhu X, Chen X, Gardam MA, Uetrecht J. Mild isoniazid-induced liver injury in humans is associated with an increase in Th17 cells and T cells producing IL-10. Chemical Research in Toxicology. 27: 683-9. PMID 24564876 DOI: 10.1021/Tx500013Z |
0.412 |
|
| 2014 |
Sharma AM, Uetrecht J. Bioactivation of drugs in the skin: Relationship to cutaneous adverse drug reactions Drug Metabolism Reviews. 46: 1-18. PMID 24164504 DOI: 10.3109/03602532.2013.848214 |
0.414 |
|
| 2014 |
Metushi IG, Sanders C, Lee WM, Larson AM, Liou I, Davern T, Fix O, Schilsky M, McCashland T, Hay JE, Murray N, Shaikh AOS, Blei A, Ganger D, Zaman A, ... ... Uetrecht J, et al. Detection of anti-isoniazid and anti-cytochrome P450 antibodies in patients with isoniazid-induced liver failure Hepatology. 59: 1084-1093. PMID 23775837 DOI: 10.1002/Hep.26564 |
0.407 |
|
| 2013 |
Ng W, Metushi IG, Uetrecht J. Hepatic effects of aminoglutethimide: a model aromatic amine. Journal of Immunotoxicology. 12: 24-32. PMID 24350727 DOI: 10.3109/1547691X.2013.867912 |
0.502 |
|
| 2013 |
Metushi IG, Uetrecht J. Isoniazid-induced liver injury and immune response in mice. Journal of Immunotoxicology. 11: 383-92. PMID 24303880 DOI: 10.3109/1547691X.2013.860644 |
0.459 |
|
| 2013 |
Metushi IG, Uetrecht J. Lack of liver injury in Wistar rats treated with the combination of isoniazid and rifampicin. Molecular and Cellular Biochemistry. 387: 9-17. PMID 24150712 DOI: 10.1007/S11010-013-1864-7 |
0.363 |
|
| 2013 |
Zhang X, Sharma AM, Uetrecht J. Identification of danger signals in nevirapine-induced skin rash. Chemical Research in Toxicology. 26: 1378-83. PMID 23947594 DOI: 10.1021/Tx400232S |
0.616 |
|
| 2013 |
Ng W, Uetrecht J. Effect of aminoglutethimide on neutrophils in rats: implications for idiosyncratic drug-induced blood dyscrasias. Chemical Research in Toxicology. 26: 1272-81. PMID 23889370 DOI: 10.1021/Tx400224J |
0.474 |
|
| 2013 |
Sharma AM, Novalen M, Tanino T, Uetrecht JP. 12-OH-nevirapine sulfate, formed in the skin, is responsible for nevirapine-induced skin rash. Chemical Research in Toxicology. 26: 817-27. PMID 23590230 DOI: 10.1021/Tx400098Z |
0.311 |
|
| 2013 |
Uetrecht J, Naisbitt DJ. Idiosyncratic adverse drug reactions: current concepts. Pharmacological Reviews. 65: 779-808. PMID 23476052 DOI: 10.1124/Pr.113.007450 |
0.485 |
|
| 2013 |
Sharma AM, Klarskov K, Uetrecht J. Nevirapine bioactivation and covalent binding in the skin Chemical Research in Toxicology. 26: 410-421. PMID 23387501 DOI: 10.1021/Tx3004938 |
0.351 |
|
| 2013 |
Zhu X, Uetrecht J. A novel T(H)17-type cell is rapidly increased in the liver in response to acetaminophen-induced liver injury: T(H)17 cells and the innate immune response. Journal of Immunotoxicology. 10: 287-91. PMID 23039944 DOI: 10.3109/1547691X.2012.724730 |
0.403 |
|
| 2012 |
Metushi IG, Nakagawa T, Uetrecht J. Direct oxidation and covalent binding of isoniazid to rodent liver and human hepatic microsomes: humans are more like mice than rats. Chemical Research in Toxicology. 25: 2567-76. PMID 23016703 DOI: 10.1021/Tx300341R |
0.456 |
|
| 2012 |
Ng W, Uetrecht J. Changes in gene expression induced by aromatic amine drugs: testing the danger hypothesis. Journal of Immunotoxicology. 10: 178-91. PMID 22970684 DOI: 10.3109/1547691X.2012.707699 |
0.477 |
|
| 2012 |
Sharma AM, Li Y, Novalen M, Hayes MA, Uetrecht J. Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury. Chemical Research in Toxicology. 25: 1708-19. PMID 22793666 DOI: 10.1021/Tx300172S |
0.402 |
|
| 2012 |
Ng W, Lobach AR, Zhu X, Chen X, Liu F, Metushi IG, Sharma A, Li J, Cai P, Ip J, Novalen M, Popovic M, Zhang X, Tanino T, Nakagawa T, ... ... Uetrecht J, et al. Animal models of idiosyncratic drug reactions. Advances in Pharmacology (San Diego, Calif.). 63: 81-135. PMID 22776640 DOI: 10.1016/B978-0-12-398339-8.00003-3 |
0.784 |
|
| 2011 |
Metushi IG, Cai P, Zhu X, Nakagawa T, Uetrecht JP. A fresh look at the mechanism of isoniazid-induced hepatotoxicity. Clinical Pharmacology and Therapeutics. 89: 911-4. PMID 21412230 DOI: 10.1038/Clpt.2010.355 |
0.318 |
|
| 2011 |
Zhu X, Li J, Liu F, Uetrecht JP. Involvement of T helper 17 cells in D-penicillamine-induced autoimmune disease in Brown Norway rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 331-8. PMID 21227906 DOI: 10.1093/Toxsci/Kfq392 |
0.409 |
|
| 2011 |
Zhang X, Zhang X, Liu F, Chen X, Zhu X, Uetrecht J. Involvement of the immune system in idiosyncratic drug reactions. Drug Metabolism and Pharmacokinetics. 26: 47-59. PMID 21084762 DOI: 10.2133/Dmpk.Dmpk-10-Rv-085 |
0.687 |
|
| 2011 |
Li J, Zhu X, Liu F, Cai P, Sanders C, Lee WM, Uetrecht J. Cytokine and autoantibody patterns in acute liver failure. Journal of Immunotoxicology. 7: 157-64. PMID 20039781 DOI: 10.3109/15476910903501748 |
0.42 |
|
| 2011 |
Zhang X, Liu F, Chen X, Zhu X, Uetrecht J. Corrections to “Involvement of the Immune System in Idiosyncratic Drug Reactions” Drug Metabolism and Pharmacokinetics. 26: 440. DOI: 10.2133/Dmpk.Dmpk-11-Er-904 |
0.403 |
|
| 2010 |
Iverson S, Kautiainen A, Ip J, Uetrecht JP. Effect of clozapine on neutrophil kinetics in rabbits. Chemical Research in Toxicology. 23: 1184-91. PMID 20553052 DOI: 10.1021/Tx100035K |
0.763 |
|
| 2010 |
Adams DH, Ju C, Ramaiah SK, Uetrecht J, Jaeschke H. Mechanisms of immune-mediated liver injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 307-21. PMID 20071422 DOI: 10.1093/Toxsci/Kfq009 |
0.471 |
|
| 2010 |
Li J, Uetrecht JP. The danger hypothesis applied to idiosyncratic drug reactions. Handbook of Experimental Pharmacology. 493-509. PMID 20020274 DOI: 10.1007/978-3-642-00663-0_18 |
0.485 |
|
| 2010 |
Popovic M, Shenton JM, Chen J, Baban A, Tharmanathan T, Mannargudi B, Abdulla D, Uetrecht JP. Nevirapine hypersensitivity. Handbook of Experimental Pharmacology. 437-51. PMID 20020271 DOI: 10.1007/978-3-642-00663-0_15 |
0.397 |
|
| 2009 |
Uetrecht J. Immunoallergic drug-induced liver injury in humans. Seminars in Liver Disease. 29: 383-92. PMID 19826972 DOI: 10.1055/S-0029-1240007 |
0.511 |
|
| 2009 |
Chen X, Tharmanathan T, Mannargudi B, Gou H, Uetrecht JP. A study of the specificity of lymphocytes in nevirapine-induced skin rash. The Journal of Pharmacology and Experimental Therapeutics. 331: 836-41. PMID 19734442 DOI: 10.1124/Jpet.109.157362 |
0.428 |
|
| 2009 |
Li J, Uetrecht JP. D-penicillamine-induced autoimmunity: relationship to macrophage activation. Chemical Research in Toxicology. 22: 1526-33. PMID 19575532 DOI: 10.1021/Tx900128P |
0.42 |
|
| 2009 |
Mannargudi B, McNally D, Reynolds W, Uetrecht J. Bioactivation of minocycline to reactive intermediates by myeloperoxidase, horseradish peroxidase, and hepatic microsomes: implications for minocycline-induced lupus and hepatitis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 1806-18. PMID 19505990 DOI: 10.1124/Dmd.109.027292 |
0.395 |
|
| 2009 |
Li J, Mannargudi B, Uetrecht JP. Covalent binding of penicillamine to macrophages: implications for penicillamine-induced autoimmunity. Chemical Research in Toxicology. 22: 1277-84. PMID 19462940 DOI: 10.1021/Tx900087Z |
0.417 |
|
| 2009 |
Uetrecht J. Immune-mediated adverse drug reactions. Chemical Research in Toxicology. 22: 24-34. PMID 19149477 DOI: 10.1021/Tx800389U |
0.488 |
|
| 2009 |
Uetrecht J. S12: Idiosyncratic hepatotoxicity: Mechanisms and predictability Experimental and Toxicologic Pathology. 61: 262. DOI: 10.1016/J.Etp.2009.02.013 |
0.486 |
|
| 2008 |
Chen J, Mannargudi BM, Xu L, Uetrecht J. Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash. Chemical Research in Toxicology. 21: 1862-70. PMID 18729332 DOI: 10.1021/Tx800177K |
0.402 |
|
| 2008 |
Lu W, Li X, Uetrecht JP. Changes in gene expression induced by carbamazepine and phenytoin: testing the danger hypothesis. Journal of Immunotoxicology. 5: 107-13. PMID 18569379 DOI: 10.1080/15476910802085723 |
0.473 |
|
| 2008 |
Lu W, Uetrecht JP. Peroxidase-mediated bioactivation of hydroxylated metabolites of carbamazepine and phenytoin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1624-36. PMID 18463199 DOI: 10.1124/Dmd.107.019554 |
0.429 |
|
| 2008 |
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS. Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1637-49. PMID 18463198 DOI: 10.1124/Dmd.107.019562 |
0.359 |
|
| 2008 |
Ip J, Wilson JX, Uetrecht JP. Testing the hypothesis that vitamin C deficiency is a risk factor for clozapine-induced agranulocytosis using guinea pigs and ODS rats. Chemical Research in Toxicology. 21: 869-73. PMID 18380445 DOI: 10.1021/Tx7004025 |
0.331 |
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| 2008 |
Ip J, Uetrecht JP. Testing the hypothesis that selenium deficiency is a risk factor for clozapine-induced agranulocytosis in rats. Chemical Research in Toxicology. 21: 874-8. PMID 18380444 DOI: 10.1021/Tx7004037 |
0.463 |
|
| 2007 |
Pacitto SR, Uetrecht JP, Boutros PC, Popovic M. Changes in gene expression induced by tienilic Acid and sulfamethoxazole: testing the danger hypothesis. Journal of Immunotoxicology. 4: 253-66. PMID 18958736 DOI: 10.1080/15476910701680020 |
0.44 |
|
| 2007 |
Uetrecht J. Idiosyncratic drug reactions: past, present, and future. Chemical Research in Toxicology. 21: 84-92. PMID 18052104 DOI: 10.1021/Tx700186P |
0.482 |
|
| 2007 |
Lu W, Uetrecht JP. Possible bioactivation pathways of lamotrigine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1050-6. PMID 17409271 DOI: 10.1124/Dmd.107.015271 |
0.389 |
|
| 2007 |
Uetrecht J. Evaluation of which reactive metabolite, if any, is responsible for a specific idiosyncratic reaction. Drug Metabolism Reviews. 38: 745-53. PMID 17145699 DOI: 10.1080/03602530600959615 |
0.468 |
|
| 2007 |
Uetrecht J. Idiosyncratic drug reactions: current understanding. Annual Review of Pharmacology and Toxicology. 47: 513-39. PMID 16879083 DOI: 10.1146/Annurev.Pharmtox.47.120505.105150 |
0.479 |
|
| 2006 |
Ip J, Uetrecht JP. In vitro and animal models of drug-induced blood dyscrasias. Environmental Toxicology and Pharmacology. 21: 135-40. PMID 21783650 DOI: 10.1016/J.Etap.2005.07.003 |
0.478 |
|
| 2006 |
Popovic M, Caswell JL, Mannargudi B, Shenton JM, Uetrecht JP. Study of the sequence of events involved in nevirapine-induced skin rash in Brown Norway rats. Chemical Research in Toxicology. 19: 1205-14. PMID 16978025 DOI: 10.1021/Tx0601152 |
0.334 |
|
| 2006 |
Uetrecht J. Role of animal models in the study of drug-induced hypersensitivity reactions. The Aaps Journal. 7: E914-21. PMID 16594644 DOI: 10.1208/Aapsj070489 |
0.465 |
|
| 2006 |
Uetrecht JP. Chapter 5 Idiosyncratic Drug Reactions: Clinical Evidence for Mechanistic Hypotheses Advances in Molecular Toxicology. 1: 139-183. DOI: 10.1016/S1872-0854(06)01005-8 |
0.443 |
|
| 2005 |
Shenton JM, Popovic M, Chen J, Masson MJ, Uetrecht JP. Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat. Chemical Research in Toxicology. 18: 1799-813. PMID 16359170 DOI: 10.1021/Tx0501132 |
0.412 |
|
| 2005 |
Gardner I, Popović M, Zahid N, Uetrecht JP. A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo. Chemical Research in Toxicology. 18: 1384-94. PMID 16167830 DOI: 10.1021/Tx050095O |
0.45 |
|
| 2005 |
Pearce RE, Uetrecht JP, Leeder JS. Pathways of carbamazepine bioactivation in vitro: II. The role of human cytochrome P450 enzymes in the formation of 2-hydroxyiminostilbene. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1819-26. PMID 16135660 DOI: 10.1124/Dmd.105.004861 |
0.359 |
|
| 2005 |
Séguin B, Boutros PC, Li X, Okey AB, Uetrecht JP. Gene expression profiling in a model of D-penicillamine-induced autoimmunity in the Brown Norway rat: predictive value of early signs of danger. Chemical Research in Toxicology. 18: 1193-202. PMID 16097792 DOI: 10.1021/Tx050040M |
0.408 |
|
| 2005 |
Uetrecht J. Current trends in drug-induced autoimmunity. Autoimmunity Reviews. 4: 309-14. PMID 15990079 DOI: 10.1016/J.Autrev.2005.01.002 |
0.464 |
|
| 2005 |
Uetrecht J. Role of drug metabolism for breaking tolerance and the localization of drug hypersensitivity. Toxicology. 209: 113-8. PMID 15767022 DOI: 10.1016/J.Tox.2004.12.019 |
0.485 |
|
| 2005 |
Popović M, Nierkens S, Pieters R, Uetrecht J. Investigating the role of 2-phenylpropenal in felbamate-induced idiosyncratic drug reactions. Chemical Research in Toxicology. 17: 1568-76. PMID 15606131 DOI: 10.1021/TX0498197 |
0.409 |
|
| 2005 |
Séguin B, Masson MJ, Uetrecht J. D-penicillamine-induced autoimmunity in the Brown Norway rat: role for both T and non-T splenocytes in adoptive transfer of tolerance. Chemical Research in Toxicology. 17: 1299-302. PMID 15487889 DOI: 10.1021/Tx0498399 |
0.364 |
|
| 2004 |
Masson MJ, Teranishi M, Shenton JM, Uetrecht JP. Investigation of the involvement of macrophages and T cells in D-penicillamine-induced autoimmunity in the Brown Norway rat. Journal of Immunotoxicology. 1: 79-93. PMID 18958641 DOI: 10.1080/15476910490496258 |
0.378 |
|
| 2004 |
Shenton JM, Chen J, Uetrecht JP. Animal models of idiosyncratic drug reactions. Chemico-Biological Interactions. 150: 53-70. PMID 15522261 DOI: 10.1016/J.Cbi.2004.09.001 |
0.492 |
|
| 2004 |
Masson MJ, Uetrecht JP. Tolerance induced by low dose D-penicillamine in the brown Norway rat model of drug-induced autoimmunity is immune-mediated. Chemical Research in Toxicology. 17: 82-94. PMID 14727922 DOI: 10.1021/Tx034195A |
0.413 |
|
| 2003 |
Williams DP, O'Donnell CJ, Maggs JL, Leeder JS, Uetrecht J, Pirmohamed M, Park BK. Bioactivation of clozapine by murine cardiac tissue in vivo and in vitro. Chemical Research in Toxicology. 16: 1359-64. PMID 14565776 DOI: 10.1021/Tx034035Z |
0.325 |
|
| 2003 |
Shenton JM, Teranishi M, Abu-Asab MS, Yager JA, Uetrecht JP. Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapine-induced skin rash in the rat. Chemical Research in Toxicology. 16: 1078-89. PMID 12971795 DOI: 10.1021/Tx034064+ |
0.381 |
|
| 2003 |
Uetrecht J. Screening for the potential of a drug candidate to cause idiosyncratic drug reactions. Drug Discovery Today. 8: 832-7. PMID 12963319 DOI: 10.1016/S1359-6446(03)02816-2 |
0.416 |
|
| 2003 |
Sēguin B, Teranishi M, Uetrecht JP. Modulation of D-penicillamine-induced autoimmunity in the Brown Norway rat using pharmacological agents that interfere with arachidonic acid metabolism or synthesis of inducible nitric oxide synthase. Toxicology. 190: 267-78. PMID 12927381 DOI: 10.1016/S0300-483X(03)00160-4 |
0.402 |
|
| 2003 |
Uetrecht J. N-oxidation of drugs associated with idiosyncratic drug reactions. Drug Metabolism Reviews. 34: 651-65. PMID 12214672 DOI: 10.1081/Dmr-120005667 |
0.422 |
|
| 2003 |
Ju C, Uetrecht JP. Mechanism of idiosyncratic drug reactions: reactive metabolite formation, protein binding and the regulation of the immune system. Current Drug Metabolism. 3: 367-77. PMID 12093356 DOI: 10.2174/1389200023337333 |
0.377 |
|
| 2002 |
Iverson S, Zahid N, Uetrecht JP. Predicting drug-induced agranulocytosis: characterizing neutrophil-generated metabolites of a model compound, DMP 406, and assessing the relevance of an in vitro apoptosis assay for identifying drugs that may cause agranulocytosis. Chemico-Biological Interactions. 142: 175-99. PMID 12399162 DOI: 10.1016/S0009-2797(02)00061-3 |
0.775 |
|
| 2002 |
Uetrecht JP. Metabolism of drugs by leukocytes. Drug Metabolism and Drug Interactions. 11: 259-82. PMID 12369752 DOI: 10.1515/DMDI.1994.11.4.259 |
0.397 |
|
| 2001 |
Sayeh E, Uetrecht JP. Factors that modify penicillamine-induced autoimmunity in Brown Norway rats: failure of the Th1/Th2 paradigm. Toxicology. 163: 195-211. PMID 11516529 DOI: 10.1016/S0300-483X(01)00385-7 |
0.765 |
|
| 2001 |
Uetrecht JP. Is it possible to more accurately predict which drug candidates will cause idiosyncratic drug reactions? Current Drug Metabolism. 1: 133-41. PMID 11465079 DOI: 10.2174/1389200003339081 |
0.443 |
|
| 2001 |
Iverson SL, Uetrecht JP. Identification of a reactive metabolite of terbinafine: insights into terbinafine-induced hepatotoxicity. Chemical Research in Toxicology. 14: 175-81. PMID 11258966 DOI: 10.1021/Tx0002029 |
0.78 |
|
| 2001 |
Guest I, Uetrecht J. Bone marrow stem cell protection from chemotherapy by low--molecular-weight compounds. Experimental Hematology. 29: 123-37. PMID 11166451 DOI: 10.1016/S0301-472X(00)00621-4 |
0.306 |
|
| 2000 |
Knowles SR, Uetrecht J, Shear NH. Idiosyncratic drug reactions: the reactive metabolite syndromes. Lancet (London, England). 356: 1587-91. PMID 11075787 DOI: 10.1016/S0140-6736(00)03137-8 |
0.401 |
|
| 2000 |
Williams DP, Pirmohamed M, Naisbitt DJ, Uetrecht JP, Park BK. Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine Molecular Pharmacology. 58: 207-216. PMID 10860943 DOI: 10.1124/Mol.58.1.207 |
0.41 |
|
| 2000 |
Liégeois JF, Zahid N, Bruhwyler J, Uetrecht J. Hypochlorous acid, a major oxidant produced by activated neutrophils, has low effect on two pyridobenzazepine derivatives, JL 3 and JL 13. Archiv Der Pharmazie. 333: 63-7. PMID 10783520 DOI: 10.1002/(Sici)1521-4184(200002)333:2/3<63::Aid-Ardp63>3.0.Co;2-C |
0.401 |
|
| 2000 |
Lai WG, Gardner I, Zahid N, Uetrecht JP. Bioactivation and covalent binding of hydroxyfluperlapine in human neutrophils: implications for fluperlapine-induced agranulocytosis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 255-63. PMID 10681368 |
0.71 |
|
| 2000 |
Guest I, Uetrecht J. Drugs toxic to the bone marrow that target the stromal cells. Immunopharmacology. 46: 103-12. PMID 10647869 DOI: 10.1016/S0162-3109(99)00168-X |
0.365 |
|
| 1999 |
Lai WG, Zahid N, Uetrecht JP. Metabolism of trimethoprim to a reactive iminoquinone methide by activated human neutrophils and hepatic microsomes. The Journal of Pharmacology and Experimental Therapeutics. 291: 292-9. PMID 10490916 |
0.708 |
|
| 1999 |
Goebel C, Vogel C, Wulferink M, Mittmann S, Sachs B, Schraa S, Abel J, Degen G, Uetrecht J, Gleichmann E. Procainamide, a drug causing lupus, induces prostaglandin H synthase-2 and formation of T cell-sensitizing drug metabolites in mouse macrophages. Chemical Research in Toxicology. 12: 488-500. PMID 10368311 DOI: 10.1021/Tx980001T |
0.41 |
|
| 1999 |
Uetrecht JP. New concepts in immunology relevant to idiosyncratic drug reactions: the "danger hypothesis" and innate immune system. Chemical Research in Toxicology. 12: 387-95. PMID 10328748 DOI: 10.1021/Tx980249I |
0.43 |
|
| 1999 |
Guest I, Sokoluk B, MacCrimmon J, Uetrecht J. Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. Toxicology. 131: 53-65. PMID 9881934 DOI: 10.1016/S0300-483X(98)00110-3 |
0.363 |
|
| 1998 |
Walmsley SL, Winn LM, Harrison ML, Uetrecht JP, Wells PG. Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV-infected patients: toxicological and pathological implications. Aids (London, England). 11: 1689-97. PMID 9386803 DOI: 10.1097/00002030-199714000-00005 |
0.306 |
|
| 1997 |
Uetrecht J, Zahid N, Tehim A, Fu JM, Rakhit S. Structural features associated with reactive metabolite formation in clozapine analogues. Chemico-Biological Interactions. 104: 117-29. PMID 9212779 DOI: 10.1016/S0009-2797(97)00017-3 |
0.415 |
|
| 1997 |
Uetrecht JP. Current trends in drug-induced autoimmunity. Toxicology. 119: 37-43. PMID 9129193 DOI: 10.1016/S0300-483X(96)03594-9 |
0.503 |
|
| 1997 |
Miyamoto G, Zahid N, Uetrecht JP. Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid. Chemical Research in Toxicology. 10: 414-9. PMID 9114978 DOI: 10.1021/Tx960190K |
0.4 |
|
| 1997 |
Uetrecht JP. Reactive metabolites and agranulocytosis. European Journal of Haematology. Supplementum. 60: 83-8. PMID 8987247 DOI: 10.1111/J.1600-0609.1996.TB01651.X |
0.372 |
|
| 1996 |
von Schmiedeberg S, Hanten U, Goebel C, Schuppe HC, Uetrecht J, Gleichmann E. T cells ignore the parent drug propylthiouracil but are sensitized to a reactive metabolite generated in vivo. Clinical Immunology and Immunopathology. 80: 162-70. PMID 8764561 DOI: 10.1006/Clin.1996.0110 |
0.42 |
|
| 1996 |
Uetrecht JP. Myeloperoxidase as a generator of drug free radicals. Biochemical Society Symposium. 61: 163-70. PMID 8660393 DOI: 10.1042/bss0610163 |
0.376 |
|
| 1996 |
Uetrecht JP. Section Review Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis: Drug-induced lupus: Possible mechanisms and their implications for prediction of which new drugs may induce lupus Expert Opinion On Investigational Drugs. 5: 851-860. DOI: 10.1517/13543784.5.7.851 |
0.468 |
|
| 1995 |
Uetrecht JP, Ma HM, MacKnight E, McClelland R. Oxidation of aminopyrine by hypochlorite to a reactive dication: possible implications for aminopyrine-induced agranulocytosis. Chemical Research in Toxicology. 8: 226-33. PMID 7766805 DOI: 10.1021/Tx00044A007 |
0.333 |
|
| 1995 |
von Schmiedeberg S, Goebel C, Gleichmann E, Uetrecht J. Neutrophils and drug metabolism. Science (New York, N.Y.). 268: 585-6. PMID 7725110 DOI: 10.1126/Science.7725110 |
0.366 |
|
| 1995 |
Furst SM, Uetrecht JP. The effect of carbamazepine and its reactive metabolite, 9-acridine carboxaldehyde, on immune cell function in vitro. International Journal of Immunopharmacology. 17: 445-52. PMID 7591369 DOI: 10.1016/0192-0561(95)00019-X |
0.447 |
|
| 1994 |
Hofstra AH, Uetrecht JP. Reactive intermediates in the oxidation of hydralazine by HOCl: the major oxidant generated by neutrophils. Chemico-Biological Interactions. 89: 183-96. PMID 8269546 DOI: 10.1016/0009-2797(93)90008-M |
0.474 |
|
| 1993 |
Furst SM, Uetrecht JP. Carbamazepine metabolism to a reactive intermediate by the myeloperoxidase system of activated neutrophils. Biochemical Pharmacology. 45: 1267-75. PMID 8385460 DOI: 10.1016/0006-2952(93)90279-6 |
0.393 |
|
| 1993 |
Hofstra AH, Uetrecht JP. Myeloperoxidase-mediated activation of xenobiotics by human leukocytes. Toxicology. 82: 221-42. PMID 8236277 DOI: 10.1016/0300-483X(93)90066-2 |
0.456 |
|
| 1992 |
Uetrecht JP. Mechanism of drug-induced lupus. Chemical Research in Toxicology. 1: 133-43. PMID 2979722 DOI: 10.1021/Tx00003A001 |
0.406 |
|
| 1992 |
Uetrecht J, Zahid N, Rubin R. Metabolism of procainamide to a hydroxylamine by human neutrophils and mononuclear leukocytes. Chemical Research in Toxicology. 1: 74-8. PMID 2979715 DOI: 10.1021/Tx00001A013 |
0.459 |
|
| 1992 |
Uetrecht J, Zahid N. N-chlorination of phenytoin by myeloperoxidase to a reactive metabolite. Chemical Research in Toxicology. 1: 148-51. PMID 2856515 DOI: 10.1021/Tx00003A004 |
0.329 |
|
| 1992 |
de Morais SM, Uetrecht JP, Wells PG. Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome. Gastroenterology. 102: 577-86. PMID 1732127 DOI: 10.1016/0016-5085(92)90106-9 |
0.321 |
|
| 1992 |
Gupta A, Eggo MC, Uetrecht JP, Cribb AE, Daneman D, Rieder MJ, Shear NH, Cannon M, Spielberg SP. Drug-induced hypothyroidism: the thyroid as a target organ in hypersensitivity reactions to anticonvulsants and sulfonamides. Clinical Pharmacology and Therapeutics. 51: 56-67. PMID 1732077 DOI: 10.1038/Clpt.1992.8 |
0.377 |
|
| 1992 |
Uetrecht JP, Zahid N. N-Chlorination and oxidation of procainamide by myeloperoxidase: toxicological implications. Chemical Research in Toxicology. 4: 218-22. PMID 1664258 DOI: 10.1021/Tx00020A015 |
0.401 |
|
| 1992 |
Uetrecht JP. The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions. Drug Metabolism Reviews. 24: 299-366. PMID 1628536 DOI: 10.3109/03602539208996297 |
0.51 |
|
| 1992 |
Uetrecht JP. Metabolism of clozapine by neutrophils. Possible implications for clozapine-induced agranulocytosis. Drug Safety. 51-6. PMID 1503678 DOI: 10.2165/00002018-199200071-00011 |
0.53 |
|
| 1991 |
Uetrecht J. Metabolism of drugs by activated leukocytes: implications for drug-induced lupus and other drug hypersensitivity reactions. Advances in Experimental Medicine and Biology. 283: 121-32. PMID 2068978 DOI: 10.1007/978-1-4684-5877-0_13 |
0.51 |
|
| 1990 |
Uetrecht J. Mechanism of hypersensitivity reactions: proposed involvement of reactive metabolites generated by activated leukocytes. Trends in Pharmacological Sciences. 10: 463-7. PMID 2692259 DOI: 10.1016/S0165-6147(89)80012-4 |
0.463 |
|
| 1990 |
Uetrecht J. Drug metabolism by leukocytes and its role in drug-induced lupus and other idiosyncratic drug reactions. Critical Reviews in Toxicology. 20: 213-35. PMID 2178625 DOI: 10.3109/10408449009089863 |
0.378 |
|
| 1989 |
Rieder MJ, Uetrecht J, Shear NH, Cannon M, Miller M, Spielberg SP. Diagnosis of sulfonamide hypersensitivity reactions by in-vitro "rechallenge" with hydroxylamine metabolites. Annals of Internal Medicine. 110: 286-9. PMID 2913915 DOI: 10.7326/0003-4819-110-4-286 |
0.354 |
|
| 1989 |
Uetrecht JP. Idiosyncratic drug reactions: possible role of reactive metabolites generated by leukocytes. Pharmaceutical Research. 6: 265-73. PMID 2664753 DOI: 10.1023/A:1015934104984 |
0.473 |
|
| 1987 |
Rieder MJ, Uetrecht J, Soielbera SP. CHEMICAL SYNTHESIS AND IN VITRO TOXICITY OF A REACTIVE INTERMEDIATE OF SULFAMETHOXAZOLE Pediatric Research. 21: 241A-241A. DOI: 10.1203/00006450-198704010-00443 |
0.374 |
|
| 1987 |
Rieder MJ, Cannon M, Uetrecht J, Soielbera SP. SULFAMETHOXAZOLE HYPERSENSITIVITY REACTIONS ARE MEDIATED BY A HYDROXYLAMINE METABOLITE Pediatric Research. 21: 241A-241A. DOI: 10.1203/00006450-198704010-00442 |
0.376 |
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