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James Leahy - Publications

Affiliations: 
1992-1998 Department of Chemistry University of California, Berkeley, Berkeley, CA, United States 
 2012- Department of Chemistry University of South Florida, Tampa, FL, United States 
Area:
organic chemistry, medicinal chemistry
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35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mansfield CR, Quan B, Chirgwin ME, Eduful B, Hughes PF, Neveu G, Sylvester K, Ryan DH, Kafsack BFC, Haystead TAJ, Leahy JW, Fitzgerald MC, Derbyshire ER. Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome. Cell Chemical Biology. PMID 38492573 DOI: 10.1016/j.chembiol.2024.02.008  0.754
2023 Hill SE, Beaulieu-Abdelahad D, Lemus A, Webster JM, Ospina SR, Darling AL, Martin MD, Patel S, Bridenstine L, Swonger R, Paul S, Blackburn R, Calcul L, Dickey CA, Leahy JW, et al. . Acs Chemical Biology. PMID 37144894 DOI: 10.1021/acschembio.2c00919  0.602
2022 Botnar A, Lawrence G, Maher SP, Vantaux A, Witkowski B, Shiau JC, Merino EF, De Vore D, Yang C, Murray C, Cassera MB, Leahy JW, Kyle DE. Alkyne modified purines for assessment of activation of Plasmodium vivax hypnozoites and growth of pre-erythrocytic and erythrocytic stages in Plasmodium spp. International Journal For Parasitology. PMID 35447149 DOI: 10.1016/j.ijpara.2022.03.003  0.717
2018 Sabbagh JJ, Cordova RA, Zheng D, Criado-Marrero M, Lemus A, Li P, Baker JD, Nordhues BA, Darling AL, Martinez-Licha C, Rutz DA, Patel S, Buchner J, Leahy JW, Koren J, et al. Targeting the FKBP51/GR/Hsp90 complex to identify functionally relevant treatments for depression and PTSD. Acs Chemical Biology. PMID 29893552 DOI: 10.1021/Acschembio.8B00454  0.632
2018 Shultz ZP, Lawrence GA, Jacobson JM, Cruz EJ, Leahy JW. Enantioselective Total Synthesis of Cannabinoids-A Route for Analogue Development. Organic Letters. PMID 29293352 DOI: 10.1021/acs.orglett.7b03668  0.716
2018 Leahy JW, Carroll DC, McElhone KE. A synthetic approach to the phorboxazoles – A strategy for the synthesis of the C1–C19 polyketide fragment Tetrahedron Letters. 59: 117-120. DOI: 10.1016/J.TETLET.2017.12.007  0.306
2017 Dempsey DR, Nichols DA, Battistini MR, Pemberton O, Ospina SR, Zhang X, Carpenter AM, O'Flynn BG, Leahy JW, Kanwar A, Lewandowski EM, Chen Y, Merkler DJ. Structural and Mechanistic Analysis of Drosophila melanogaster Agmatine N-Acetyltransferase, an Enzyme that Catalyzes the Formation of N-Acetylagmatine. Scientific Reports. 7: 13432. PMID 29044148 DOI: 10.1038/S41598-017-13669-6  0.552
2017 Giulianotti MA, Vesely BA, Azhari A, Souza A, LaVoi T, Houghten RA, Kyle DE, Leahy JW. Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries. Acs Medicinal Chemistry Letters. 8: 802-807. PMID 28835792 DOI: 10.1021/acsmedchemlett.7b00045  0.591
2017 Kanwar A, Eduful BJ, Barbeto L, Carletti Bonomo P, Lemus A, Vesely BA, Mutka TS, Azhari A, Kyle DE, Leahy JW. Synthesis and Activity of a New Series of Antileishmanial Agents. Acs Medicinal Chemistry Letters. 8: 797-801. PMID 28835791 DOI: 10.1021/Acsmedchemlett.7B00039  0.646
2016 Shultz Z, Leahy JW. Synthesis of the phorboxazoles-potent, architecturally novel marine natural products. The Journal of Antibiotics. 69: 220-52. PMID 26956795 DOI: 10.1038/Ja.2016.8  0.797
2010 Lafontaine JA, Provencal DP, Gardelli C, Leahy JW. ChemInform Abstract: The Enantioselective Total Synthesis of the Antitumor Macrolide Natural Product Rhizoxin D. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199932257  0.731
2010 BOYER SJ, LEAHY JW. ChemInform Abstract: Carbocyclic Nucleoside Analogues. Part 1. Concise Enantioselective Synthesis of Functionalized Cyclopentanes and Formal Total Synthesis of Aristeromycin. Cheminform. 28: no-no. DOI: 10.1002/CHIN.199744256  0.38
2010 SMITH ABI, CONDON SM, MCCAULEY JA, LEAZER JLJ, LEAHY JW, MALECZKA REJ. ChemInform Abstract: A Unified Total Synthesis of the Immunomodulators (-)-Rapamycin and (-) -27-Demethoxyrapamycin: Assembly of the Common C(1-20) Perimeter and Final Elaboration. Cheminform. 28: no-no. DOI: 10.1002/chin.199719249  0.337
2010 SMITH ABI, CONDON SM, MCCAULEY JA, LEAZER JLJ, LEAHY JW, MALECZKA REJ. ChemInform Abstract: A Unified Total Synthesis of the Immunomodulators (-)-Rapamycin and (-) -27-Demethoxyrapamycin: Construction of the C(21-42) Perimeters. Cheminform. 28: no-no. DOI: 10.1002/chin.199719248  0.349
2010 PROVENCAL DP, GARDELLI C, LAFONTAINE JA, LEAHY JW. ChemInform Abstract: Rhizoxin Synthetic Studies. Part 2. Synthesis of the Left Hand (C(10) to C(19)) and Polyene Fragments. Cheminform. 26: no-no. DOI: 10.1002/chin.199550215  0.722
2010 LAFONTAINE JA, LEAHY JW. ChemInform Abstract: Rhizoxin Synthetic Studies. Part 1. Synthesis of the Right Hand (C(1) to C(9)) Portion via a “Pinwheel” Approach. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199550214  0.727
2010 HIRSCHMANN R, SPRENGELER PA, KAWASAKI T, LEAHY JW, SHAKESPEARE WC, SMITH ABI. ChemInform Abstract: The Versatile Steroid Nucleus: Design and Synthesis of a Peptidomimetic Employing This Novel Scaffold. Cheminform. 24: no-no. DOI: 10.1002/chin.199334260  0.302
2010 HIRSCHMANN R, SPRENGELER PA, KAWASAKI T, LEAHY JW, SHAKESPEARE WC, SMITH ABI. ChemInform Abstract: The First Design and Synthesis of a Steroidal Peptidomimetic. The Potential Value of Peptidomimetics in Elucidating the Bioactive Conformation of Peptide Ligands. Cheminform. 24: no-no. DOI: 10.1002/chin.199314252  0.616
2010 SMITH ABI, LEAHY JW, NODA I, REMISZEWSKI SW, LIVERTON NJ, ZIBUCK R. ChemInform Abstract: Total Synthesis of the Latrunculins. Cheminform. 23: no-no. DOI: 10.1002/chin.199232253  0.344
2003 Lafontaine JA, Provencal DP, Gardelli C, Leahy JW. Enantioselective total synthesis of the antitumor macrolide rhizoxin D. The Journal of Organic Chemistry. 68: 4215-34. PMID 12762720 DOI: 10.1021/jo034011x  0.736
2002 Folkes A, Brown SD, Canne LE, Chan J, Engelhardt E, Epshteyn S, Faint R, Golec J, Hanel A, Kearney P, Leahy JW, Mac M, Matthews D, Prisbylla MP, Sanderson J, et al. Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1. Bioorganic & Medicinal Chemistry Letters. 12: 1063-6. PMID 11909718 DOI: 10.1016/S0960-894X(02)00078-1  0.318
1999 Lafontaine JA, Provencal DP, Gardelli C, Leahy JW. The enantioselective total synthesis of the antitumor macrolide natural product rhizoxin D Tetrahedron Letters. 40: 4145-4148. DOI: 10.1016/S0040-4039(99)00731-5  0.729
1997 Gardinier KM, Leahy JW. Enantiospecific Total Synthesis of the Potent Antitumor Macrolides Cryptophycins 1 and 8. The Journal of Organic Chemistry. 62: 7098-7099. PMID 11671811  0.802
1997 Boyer SJ, Leahy JW. Carbocyclic Nucleoside Analogs. 1. Concise Enantioselective Synthesis of Functionalized Cyclopentanes and Formal Total Synthesis of Aristeromycin The Journal of Organic Chemistry. 62: 3976-3980. DOI: 10.1021/jo970153d  0.373
1997 Smith AB, Condon SM, McCauley JA, Leazer JL, Leahy JW, Maleczka RE. A unified total synthesis of the immunomodulators (-)-rapamycin and (-)-27-demethoxyrapamycin: Assembly of the common C(1-20) perimeter and final elaboration Journal of the American Chemical Society. 119: 962-973. DOI: 10.1021/Ja963067O  0.66
1997 Smith AB, Condon SM, McCauley JA, Leazer JL, Leahy JW, Maleczka RE. A unified total synthesis of the immunomodulators (-)-rapamycin and (-)-27-demethoxyrapamycin: Construction of the C(21-42) perimeters Journal of the American Chemical Society. 119: 947-961. DOI: 10.1021/Ja963066W  0.66
1995 Smith AB, Condon SM, McCauley JA, Leazer JL, Leahy JW, Maleczka RE. Total synthesis of rapamycin and demethoxyrapamycin Journal of the American Chemical Society. 117: 5407-5408. DOI: 10.1021/Ja00124A043  0.644
1995 Provencal DP, Gardelli C, Lafontaine JA, Leahy JW. Rhizoxin synthetic studies. 2. Synthesis of the left hand [C(10) to C(19)] and polyene fragments Tetrahedron Letters. 36: 6033-6036. DOI: 10.1016/0040-4039(95)01194-M  0.718
1995 Lafontaine JA, Leahy JW. Rhizoxin synthetic studies. 1. Synthesis of the right hand [C(1) to C(9)]portion via a “pinwheel” approach Tetrahedron Letters. 36: 6029-6032. DOI: 10.1016/0040-4039(95)01193-L  0.723
1994 Smith AB, Maleczka RE, Leazer JL, Leahy JW, McCauley JA, Condon SM. Rapamycin synthetic studies. 2. Elaboration of the C(10)-C(26) perimeter Tetrahedron Letters. 35: 4911-4914. DOI: 10.1016/S0040-4039(00)73280-1  0.591
1994 Smith AB, Condon SM, McCauley JA, Leahy JW, Leazer JL, Maleczka RE. Rapamycin synthetic studies. 1. Construction of the C(27)-C(42) subunit Tetrahedron Letters. 35: 4907-4910. DOI: 10.1016/S0040-4039(00)73279-5  0.584
1993 Hirschmann R, Sprengeler PA, Kawasaki T, Leahy JW, Shakespeare WC, Smith AB. The versatile steroid nucleus: Design and synthesis of a peptidomimetic employing this novel scaffold. Tetrahedron. 49: 3665-3676. DOI: 10.1016/S0040-4020(01)90222-4  0.635
1992 Hirschmann R, Sprengeler PA, Kawasaki T, Leahy JW, Shakespeare WC, Smith AB. The first design and synthesis of a steroidal peptidomimetic. The potential value of peptidomimetics in elucidating the bioactive conformation of peptide ligands Journal of the American Chemical Society. 114: 9699-9701. DOI: 10.1021/Ja00050A082  0.611
1992 Smith AB, Leahy JW, Noda I, Remiszewski SW, Liverton NJ, Zibuck R. Total synthesis of the latrunculins Journal of the American Chemical Society. 114: 2995-3007. DOI: 10.1021/ja00034a036  0.355
1989 Leahy J, Schneller S. The Synthesis of the Carbocyclic Derivative of lin-Benzo-Separated 2',3'-Dideoxyinosine Nucleosides, Nucleotides and Nucleic Acids. 8: 1081-1082. DOI: 10.1080/07328318908054289  0.61
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