David E. Metzler - Publications

Affiliations: 
Biochemistry Iowa State University, Ames, IA, United States 

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
1997 Metzler DE. Nuclear magnetic resonance in study of active sites of pyridoxal-dependent enzymes. Methods in Enzymology. 280: 30-40. PMID 9211302 DOI: 10.1016/S0076-6879(97)80098-5  0.318
1997 Mollova ET, Metzler DE, Kintanar A, Kagamiyama H, Hayashi H, Hirotsu K, Miyahara I. Use of 1H-15N heteronuclear multiple-quantum coherence NMR spectroscopy to study the active site of aspartate aminotransferase. Biochemistry. 36: 615-25. PMID 9012676 DOI: 10.1021/Bi9615811  0.315
1994 Chu WC, Metzler DE. Enzymatically active truncated cat brain glutamate decarboxylase: expression, purification, and absorption spectrum. Archives of Biochemistry and Biophysics. 313: 287-95. PMID 8080275 DOI: 10.1006/Abbi.1994.1390  0.346
1994 Firsov LM, Neustroev KN, Aleshin AE, Metzler CM, Metzler DE, Scott RD, Stoffer B, Christensen T, Svensson B. NMR spectroscopy of exchangeable protons of glucoamylase and of complexes with inhibitors in the 9-15-ppm range. European Journal of Biochemistry / Febs. 223: 293-302. PMID 8033904 DOI: 10.1111/J.1432-1033.1994.Tb18994.X  0.327
1993 Yano T, Hinoue Y, Chen VJ, Metzler DE, Miyahara I, Hirotsu K, Kagamiyama H. Role of an active site residue analyzed by combination of mutagenesis and coenzyme analog. Journal of Molecular Biology. 234: 1218-29. PMID 8263922 DOI: 10.1006/Jmbi.1993.1672  0.301
1991 Metzler CM, Metzler DE, Kintanar A, Scott RD, Marceau M. NMR spectra of exchangeable protons of pyridoxal phosphate-dependent enzymes. Biochemical and Biophysical Research Communications. 178: 385-92. PMID 2069576 DOI: 10.1016/0006-291X(91)91825-W  0.355
1991 Metzler CM, Viswanath R, Metzler DE. Equilibria and absorption spectra of tryptophanase. The Journal of Biological Chemistry. 266: 9374-81. PMID 2033039 DOI: 10.1016/B978-0-08-040820-0.50063-7  0.361
1990 Kraus GA, Kim H, Thomas PJ, Metzler DE, Metzler CM, Taylor JE. Analogs of Glutamic Acid: Synthesis and Biological Evaluation Synthetic Communications. 20: 2667-2673. DOI: 10.1080/00397919008051475  0.336
1989 Miura R, Metzler CM, Metzler DE. Reactions of phosphonate analogs of pyridoxal phosphate with apo-aspartate aminotransferase. Archives of Biochemistry and Biophysics. 270: 526-40. PMID 2705779 DOI: 10.1016/0003-9861(89)90535-3  0.401
1988 Metzler CM, Mitra J, Metzler DE, Makinen MW, Hyde CC, Rogers PH, Arnone A. Correlation of polarized absorption spectroscopic and X-ray diffraction studies of crystalline cytosolic aspartate aminotransferase of pig hearts. Journal of Molecular Biology. 203: 197-220. PMID 3184186 DOI: 10.1016/0022-2836(88)90102-7  0.309
1988 Metzler CM, Harris AG, Metzler DE. Spectroscopic studies of quinonoid species from pyridoxal 5'-phosphate. Biochemistry. 27: 4923-33. PMID 3167020 DOI: 10.1021/Bi00413A050  0.301
1988 Mitra J, Metzler DE. Schiff bases of pyridoxal 5′-phosphate with Tris and glycine Bba - General Subjects. 965: 93-96. DOI: 10.1016/0304-4165(88)90156-0  0.315
1987 Metzler CM, Metzler DE. Quantitative description of absorption spectra of a pyridoxal phosphate-dependent enzyme using lognormal distribution curves. Analytical Biochemistry. 166: 313-27. PMID 3434776 DOI: 10.1016/0003-2697(87)90580-X  0.354
1985 Scott RD, Chang YC, Graves DJ, Metzler DE. Studies of 6-fluoropyridoxal and 6-fluoropyridoxamine 5'-phosphates in cytosolic aspartate aminotransferase. Biochemistry. 24: 7668-81. PMID 4092032 DOI: 10.1021/Bi00347A026  0.379
1983 Han CN, Iwata C, Metzler DE. Phosphonate analogues of pyridoxal phosphate with shortened side chains. Journal of Medicinal Chemistry. 26: 595-8. PMID 6339724 DOI: 10.1021/Jm00358A027  0.355
1982 Schmidt J, Scott RD, Metzler DE. Covalently modified peptides isolated from aspartate aminotransferase after reaction with pyridoxal 5'-sulfate. Biochemistry. 21: 5220-4. PMID 7171551 DOI: 10.1021/Bi00264A017  0.349
1982 Scott RD, Ueno H, Metzler DE. Pyrrolopyridine derivatives from pyridoxal 5'-sulfate. Biochemistry. 21: 5213-9. PMID 7171550 DOI: 10.1021/Bi00264A016  0.379
1982 Ueno H, Likos JJ, Metzler DE. Chemistry of the inactivation of cytosolic aspartate aminotransferase by serine O-sulfate. Biochemistry. 21: 4387-93. PMID 6812625 DOI: 10.1021/Bi00261A030  0.33
1980 Walsh JJ, Metzler DE, Powell D, Jacobson RA. 2-(Hydroxymethyl) aspartic acid: synthesis, crystal structure, and reaction with a transaminase Journal of the American Chemical Society. 102: 7136-7138. DOI: 10.1021/Ja00543A058  0.335
1979 Yang BI, Metzler DE. Pyridoxal 5'-phosphate and analogs as probes of coenzyme-protein interaction. Methods in Enzymology. 62: 528-51. PMID 374981 DOI: 10.1016/0076-6879(79)62259-0  0.37
1979 Metzler CM, Rogers PH, Arnone A, Martin DS, Metzler DE. Investigation of crystalline enzyme-substrate complexes of pyridoxal phosphate-dependent enzymes. Methods in Enzymology. 62: 551-8. PMID 35732 DOI: 10.1016/0076-6879(79)62260-7  0.307
1976 Harris CM, Johnson RJ, Metzler DE. Band-shape analysis and resolution of electronic spectra of pyridoxal phosphate and other 3-hydroxypyridine-4-aldehydes. Biochimica Et Biophysica Acta. 421: 181-94. PMID 1252466 DOI: 10.1016/0304-4165(76)90284-1  0.339
1976 Miura R, Metzler DE. Interaction of a 5-trans-vinylcarboxylic acid analogue of pyridoxal 5'-phosphate with apoaspartate aminotransferase. Covalent labeling of the enzyme. Biochemistry. 15: 283-90. PMID 1247517 DOI: 10.1021/Bi00647A007  0.386
1972 Davis L, Metzler DE. 2 Pyridoxal-Linked Elimination and Replacement Reactions Enzymes. 7: 33-74. DOI: 10.1016/S1874-6047(08)60446-1  0.37
1971 Johnson RJ, Metzler DE. [1] Buffer preparation Methods in Enzymology. 22: 3-5. DOI: 10.1016/0076-6879(71)22003-6  0.324
1970 Johnson RJ, Metzler DE. [77] Analyzing spectra of vitamin B6 derivatives Methods in Enzymology. 18: 433-471. DOI: 10.1016/0076-6879(71)18345-0  0.347
1967 Huntley TE, Metzler DE. Circular dichroism of L-glutamic acid decarboxylase. Biochemical and Biophysical Research Communications. 26: 109-15. PMID 5339941 DOI: 10.1016/0006-291X(67)90220-3  0.352
1967 Song PS, Metzler DE. Photochemical degradation of flavins. IV. Studies of the anaerobic photolysis of riboflavin. Photochemistry and Photobiology. 6: 691-709. PMID 4293497 DOI: 10.1111/J.1751-1097.1967.Tb08735.X  0.449
1967 Iwata C, Metzler DE. Synthesis of vitamin B6derivatives. III. 3- (4-formyl-3-hydroxy-2-methyl-5-pyridyl)propionic acid, an analog of pyridoxal phosphate Journal of Heterocyclic Chemistry. 4: 319-324. DOI: 10.1002/Jhet.5570040302  0.361
1966 Tomita I, Brooks HG, Metzler DE. Synthesis of vitamin b6 derivatives. II. 3‐Hydroxy‐4‐hydroxymethyl‐2‐methyl‐5‐pyridine acetic acid and related substances Journal of Heterocyclic Chemistry. 3: 178-183. DOI: 10.1002/Jhet.5570030214  0.343
1966 Brooks HG, Laakso JW, Metzler DE. Synthesis of vitamin B6 derivatives I. Preparation of some isopyricloxamine derivatives from isopyridoxal Journal of Heterocyclic Chemistry. 3: 126-128. DOI: 10.1002/Jhet.5570030203  0.301
1965 Song P, Smith EC, Metzler DE. Photochemical Degradation of Flavins. II. The Mechanism of Alkaline Hydrolysis of 6,7-Dimethyl-9-formylmethylisoalloxazine1,2 Journal of the American Chemical Society. 87: 4181-4184. DOI: 10.1021/Ja01096A031  0.454
1965 Song PS, Smith EC, Metzler DE. Photochemical degradation of flavins. II. The mechanism of alkaline hydrolysis of 6,7-dimethyl-9-formylmethyusoauoxazine Journal of the American Chemical Society. 87: 4181-4184.  0.391
1963 JOHNSTON CC, GARDNER JL, SUELTER CH, METZLER DE. ACID-CATALYZED ADDITION OF WATER TO 1,4-DIHYDRONICOTINAMIDE DERIVATIVES. Biochemistry. 2: 689-96. PMID 14075099 DOI: 10.1021/Bi00904A012  0.309
1961 Davis L, Roddy F, Metzler DE. Metal chelates of imines derived from pyridoxal and amino acids Journal of the American Chemical Society. 83: 127-134. DOI: 10.1021/Ja01462A025  0.332
1959 YOUNT RG, METZLER DE. Decarboxylation of pyruvate by thiamine analogues. The Journal of Biological Chemistry. 234: 738-41. PMID 13654253  0.585
1959 YATCO-MANZO E, RODDY F, YOUNT RG, METZLER DE. The catalytic decarboxylation of pyruvate by thiamine. The Journal of Biological Chemistry. 234: 733-7. PMID 13654252  0.577
1957 Metzler DE. Equilibria between pyridoxal and amino acids and their imines Journal of the American Chemical Society. 79: 485-490. DOI: 10.1021/Ja01559A068  0.326
1956 METZLER DE, SNELL EE. Water-soluble vitamins. II. Vitamin B6, nicotinic acid, biotin, ascorbic acid. Annual Review of Biochemistry. 25: 435-62. PMID 13363318 DOI: 10.1146/annurev.bi.25.070156.002251  0.478
1955 Metzler DE, Snell EE. Spectra and Ionization Constants of the Vitamin B6 Group and Related 3-Hydroxypyridine Derivatives1 Journal of the American Chemical Society. 77: 2431-2437. DOI: 10.1021/Ja01614A022  0.501
1954 Metzler DE, Ikawa M, Snell EE. A general mechanism for vitamin B6-catalyzed reactions Journal of the American Chemical Society. 76: 648-652. DOI: 10.1021/Ja01632A004  0.516
1954 Metzler DE, Olivard J, Snell EE. Transamination of Pyridoxamine and Amino Acids with Glyoxylic Acid1 Journal of the American Chemical Society. 76: 644-648. DOI: 10.1021/Ja01632A003  0.517
1954 Metzler DE, Longenecker JB, Snell EE. The reversible catalytic cleavage of hydroxyamino acids by pyridoxal and metal salts Journal of the American Chemical Society. 76: 639-644. DOI: 10.1021/Ja01632A002  0.532
1952 OLIVARD J, METZLER DE, SNELL EE. Catalytic racemization of amino acids by pyridoxal and metal salts. The Journal of Biological Chemistry. 199: 669-74. PMID 13022674  0.491
1952 METZLER DE, SNELL EE. Deamination of serine. II. D-Serine dehydrase, a vitamin B6 enzyme from Escherichia coli. The Journal of Biological Chemistry. 198: 363-73. PMID 12999751  0.481
1952 METZLER DE, SNELL EE. Deamination of serine. I. Catalytic deamination of serine and cysteine by pyridoxal and metal salts. The Journal of Biological Chemistry. 198: 353-61. PMID 12999750  0.453
1952 Metzler DE, Snell EE. Some Transamination Reactions Involving Vitamin B61 Journal of the American Chemical Society. 74: 979-983. DOI: 10.1021/Ja01124A033  0.509
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