| Year |
Citation |
Score |
| 2025 |
Lee BS, Park YI, Liu H, Kim SG, Kim HJ, Choi JH, Rho SH, Padilla J, Roh J, Woo HG, Seo HJ, Choi MH, Jeong YJ, Lien EC, Mehdi SH, et al. The role of 7-dehydrocholesterol in inducing ER stress and apoptosis of head and neck squamous cell carcinoma. Cancer Letters. 217842. PMID 40456399 DOI: 10.1016/j.canlet.2025.217842 |
0.301 |
|
| 2025 |
Navarro-Traxler AJ, Ghisolfi L, Lien EC, Toker A. The glycosyltransferase ALG3 is an AKT substrate that regulates protein N-glycosylation. Biorxiv : the Preprint Server For Biology. PMID 40236010 DOI: 10.1101/2025.04.01.646556 |
0.696 |
|
| 2025 |
Jonker PB, Sadullozoda M, Cognet G, Saab JJA, Sokol KH, Wu VX, Kumari D, Sheehan C, Ozgurses ME, Agovino D, Croley G, Patel SA, Bock-Hughes A, Macleod KF, Shah H, ... ... Lien EC, et al. Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis. Biorxiv : the Preprint Server For Biology. PMID 40161789 DOI: 10.1101/2025.03.10.642426 |
0.316 |
|
| 2024 |
House RRJ, Tovar EA, Essenburg CJ, Dischinger PS, Ellis AE, Beddows I, Sheldon RD, Lien EC, Graveel CR, Steensma MR. NF1 deficiency drives metabolic reprogramming in ER+ breast cancer. Molecular Metabolism. 101876. PMID 38216123 DOI: 10.1016/j.molmet.2024.101876 |
0.387 |
|
| 2023 |
Jeong YJ, Rogers TJ, Anderson CE, Lien EC. Tumor lipid metabolism: a mechanistic link between diet and cancer progression. Current Opinion in Biotechnology. 84: 102993. PMID 37716318 DOI: 10.1016/j.copbio.2023.102993 |
0.336 |
|
| 2022 |
Tsang T, He Q, Cohen EB, Stottrup C, Lien EC, Zhang H, Lau CG, Chin YR. Upregulation of Receptor Tyrosine Kinase Activity and Stemness as Resistance Mechanisms to Akt Inhibitors in Breast Cancer. Cancers. 14. PMID 36291790 DOI: 10.3390/cancers14205006 |
0.457 |
|
| 2022 |
Dibble CC, Barritt SA, Perry GE, Lien EC, Geck RC, DuBois-Coyne SE, Bartee D, Zengeya TT, Cohen EB, Yuan M, Hopkins BD, Meier JL, Clohessy JG, Asara JM, Cantley LC, et al. PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Nature. PMID 35896750 DOI: 10.1038/s41586-022-04984-8 |
0.673 |
|
| 2022 |
Li Z, Ji BW, Dixit PD, Tchourine K, Lien EC, Hosios AM, Abbott KL, Rutter JC, Westermark AM, Gorodetsky EF, Sullivan LB, Vander Heiden MG, Vitkup D. Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited. Nature Metabolism. PMID 35739397 DOI: 10.1038/s42255-022-00588-8 |
0.317 |
|
| 2022 |
Gouirand V, Gicquel T, Lien EC, Jaune-Pons E, Da Costa Q, Finetti P, Metay E, Duluc C, Mayers JR, Audebert S, Camoin L, Borge L, Rubis M, Leca J, Nigri J, et al. Ketogenic HMG-CoA lyase and its product β-hydroxybutyrate promote pancreatic cancer progression. The Embo Journal. e110466. PMID 35307861 DOI: 10.15252/embj.2021110466 |
0.336 |
|
| 2020 |
Lau AN, Li Z, Danai LV, Westermark AM, Darnell AM, Ferreira R, Gocheva V, Sivanand S, Lien EC, Sapp KM, Mayers JR, Biffi G, Chin CR, Davidson SM, Tuveson DA, et al. Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma. Elife. 9. PMID 32648540 DOI: 10.7554/Elife.56782 |
0.335 |
|
| 2019 |
Lien EC, Vander Heiden MG. A framework for examining how diet impacts tumour metabolism. Nature Reviews. Cancer. PMID 31530936 DOI: 10.1038/s41568-019-0198-5 |
0.33 |
|
| 2017 |
Lien EC, Ghisolfi L, Geck RC, Asara JM, Toker A. Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT. Science Signaling. 10. PMID 29259101 DOI: 10.1126/Scisignal.Aao6604 |
0.641 |
|
| 2017 |
Lien EC, Dibble CC, Toker A. PI3K signaling in cancer: beyond AKT. Current Opinion in Cell Biology. 45: 62-71. PMID 28343126 DOI: 10.1016/J.Ceb.2017.02.007 |
0.7 |
|
| 2017 |
Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, et al. The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Science Signaling. 10. PMID 28049764 DOI: 10.1126/Scisignal.Aah4117 |
0.517 |
|
| 2016 |
Lien EC, Lyssiotis CA, Cantley LC. Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 207: 39-72. PMID 27557534 DOI: 10.1007/978-3-319-42118-6_3 |
0.66 |
|
| 2016 |
Cox AG, Hwang KL, Brown KK, Evason KJ, Beltz S, Tsomides A, O'Connor K, Galli GG, Yimlamai D, Chhangawala S, Yuan M, Lien EC, Wucherpfennig J, Nissim S, Minami A, et al. Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nature Cell Biology. PMID 27428308 DOI: 10.1038/Ncb3389 |
0.373 |
|
| 2016 |
Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402769 DOI: 10.1073/Pnas.1522223113 |
0.492 |
|
| 2016 |
Zhang J, Xu K, Liu P, Geng Y, Wang B, Gan W, Guo J, Wu F, Chin YR, Berrios C, Lien EC, Toker A, DeCaprio JA, Sicinski P, Wei W. Inhibition of Rb Phosphorylation Leads to mTORC2-Mediated Activation of Akt. Molecular Cell. PMID 27237051 DOI: 10.1016/J.Molcel.2016.04.023 |
0.637 |
|
| 2016 |
Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nature Cell Biology. PMID 27088857 DOI: 10.1038/Ncb3341 |
0.703 |
|
| 2016 |
Mancini ML, Lien EC, Toker A. Oncogenic AKT1(E17K) mutation induces mammary hyperplasia but prevents HER2-driven tumorigenesis. Oncotarget. PMID 27004402 DOI: 10.18632/Oncotarget.8191 |
0.701 |
|
| 2016 |
Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, et al. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 164: 433-446. PMID 26824656 DOI: 10.1186/2049-3002-2-S1-P86 |
0.579 |
|
| 2015 |
Cuiffo BG, Campagne A, Bell GW, Lembo A, Orso F, Lien E, Bhasin MK, Raimo M, Hanson SE, Marusyk A, Hematti P, Polyak K, Mariani O, Volinia S, Vincent-Salomon A, et al. Abstract P1-07-02: Mesenchymal stem cell regulated microRNAs converge on the speech gene FOXP2 and regulate breast cancer metastasis Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P1-07-02 |
0.401 |
|
| 2014 |
Cuiffo BG, Campagne A, Bell GW, Lembo A, Orso F, Lien EC, Bhasin MK, Raimo M, Hanson SE, Marusyk A, El-Ashry D, Hematti P, Polyak K, Mechta-Grigoriou F, Mariani O, et al. MSC-regulated microRNAs converge on the transcription factor FOXP2 and promote breast cancer metastasis. Cell Stem Cell. 15: 762-74. PMID 25515522 DOI: 10.1016/J.Stem.2014.10.001 |
0.329 |
|
| 2014 |
Cuiffo B, Campagne A, Bell GW, Lien E, Bhasin MK, Mariani O, Vincent-Salomon A, Karnoub A. Abstract 173: Tumor proximal mesenchymal stem cells initiate a pro-metastatic microRNA regulatory network which acts via convergent targeting of the speech-associated transcriptional repressor FOXP2 Cancer Research. 74: 173-173. DOI: 10.1158/1538-7445.Am2014-173 |
0.422 |
|
| 2013 |
Lien EC, Nagiec MJ, Dohlman HG. Proper protein glycosylation promotes mitogen-activated protein kinase signal fidelity. Biochemistry. 52: 115-24. PMID 23210626 DOI: 10.1021/Bi3009483 |
0.434 |
|
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