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Christina Leslie - Publications

Affiliations: 
Columbia University, New York, NY 
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60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mitra S, Malik R, Wong W, Rahman A, Hartemink AJ, Pritykin Y, Dey KK, Leslie CS. Single-cell multi-ome regression models identify functional and disease-associated enhancers and enable chromatin potential analysis. Nature Genetics. PMID 38514783 DOI: 10.1038/s41588-024-01689-8  0.355
2024 Yao D, Tycko J, Oh JW, Bounds LR, Gosai SJ, Lataniotis L, Mackay-Smith A, Doughty BR, Gabdank I, Schmidt H, Guerrero-Altamirano T, Siklenka K, Guo K, White AD, Youngworth I, ... ... Leslie C, et al. Multicenter integrated analysis of noncoding CRISPRi screens. Nature Methods. PMID 38504114 DOI: 10.1038/s41592-024-02216-7  0.527
2023 Gschwind AR, Mualim KS, Karbalayghareh A, Sheth MU, Dey KK, Jagoda E, Nurtdinov RN, Xi W, Tan AS, Jones H, Ma XR, Yao D, Nasser J, Avsec Ž, James BT, ... ... Leslie CS, et al. An encyclopedia of enhancer-gene regulatory interactions in the human genome. Biorxiv : the Preprint Server For Biology. PMID 38014075 DOI: 10.1101/2023.11.09.563812  0.596
2023 Pulecio J, Tayyebi Z, Liu D, Wong W, Luo R, Damodaran JR, Kaplan S, Cho H, Yan J, Murphy D, Rickert RW, Shukla A, Zhong A, González F, Yang D, ... ... Leslie CS, et al. Discovery of Competent Chromatin Regions in Human Embryonic Stem Cells. Biorxiv : the Preprint Server For Biology. PMID 37398096 DOI: 10.1101/2023.06.14.544990  0.303
2022 Karbalayghareh A, Sahin M, Leslie CS. Chromatin interaction aware gene regulatory modeling with graph attention networks. Genome Research. PMID 35396274 DOI: 10.1101/gr.275870.121  0.351
2020 van der Veeken J, Glasner A, Zhong Y, Hu W, Wang ZM, Bou-Puerto R, Charbonnier LM, Chatila TA, Leslie CS, Rudensky AY. The Transcription Factor Foxp3 Shapes Regulatory T Cell Identity by Tuning the Activity of trans-Acting Intermediaries. Immunity. PMID 33176163 DOI: 10.1016/j.immuni.2020.10.010  0.314
2020 Wesely J, Kotini AG, Izzo F, Luo H, Yuan H, Sun J, Georgomanoli M, Zviran A, Deslauriers AG, Dusaj N, Nimer SD, Leslie C, Landau DA, Kharas MG, Papapetrou EP. Acute Myeloid Leukemia iPSCs Reveal a Role for RUNX1 in the Maintenance of Human Leukemia Stem Cells. Cell Reports. 31: 107688. PMID 32492433 DOI: 10.1016/J.Celrep.2020.107688  0.376
2020 Leslie C. Abstract IA20: Chromatin state and scRNA-seq analysis defines a common differentiation trajectory towards T-cell exhaustion Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm19-Ia20  0.344
2019 Brown CC, Gudjonson H, Pritykin Y, Deep D, Lavallée VP, Mendoza A, Fromme R, Mazutis L, Ariyan C, Leslie C, Pe'er D, Rudensky AY. Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity. Cell. 179: 846-863.e24. PMID 31668803 DOI: 10.1016/J.Cell.2019.09.035  0.388
2019 Minuesa G, Albanese SK, Xie W, Kazansky Y, Worroll D, Chow A, Schurer A, Park SM, Rotsides CZ, Taggart J, Rizzi A, Naden LN, Chou T, Gourkanti S, Cappel D, ... ... Leslie CS, et al. Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nature Communications. 10: 2691. PMID 31217428 DOI: 10.1038/S41467-019-10523-3  0.351
2019 Pritykin Y, Leslie C. Abstract B038: A unified genome-wide analysis of dysfunctional T-cell states in cancer and chronic viral infection Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B038  0.412
2019 Pritykin Y, Leslie C. Abstract 3384: Genome-wide epigenetic and transcriptional comparison of CD8 T cell functional states between mouse models of cancer and chronic viral infection Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3384  0.326
2019 Ladewig E, Fairchild L, Scaltriti M, Leslie C, Toska E, Baselga J. Abstract 4346: PI3K pathway mediated splicing defects in ER+ breast cancers Cancer Research. 79: 4346-4346. DOI: 10.1158/1538-7445.Am2019-4346  0.316
2018 Park SM, Cho H, Thornton AM, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Taggart J, Chow A, Schurer A, Gruet A, Witkin MD, Kim JH, Shevach EM, Krivtsov A, ... ... Leslie C, et al. IKZF2 Drives Leukemia Stem Cell Self-Renewal and Inhibits Myeloid Differentiation. Cell Stem Cell. PMID 30472158 DOI: 10.1016/J.Stem.2018.10.016  0.396
2018 Nguyen D, Lu Y, Choo Z, Chin C, Prieto C, Gourkanti S, Leslie C, Kharas MG. The RNA Binding Protein MSI2 Has Increased RNA Binding Activity in Leukemic Stem Cells Compared to Normal Hematopoietic Stem Cells Blood. 132: 884-884. DOI: 10.1182/Blood-2018-99-118949  0.395
2018 Park S, Cho H, Thornton A, Barlowe TS, Chou T, Chhangawala S, Fairchild L, Chow A, Taggart J, Schurer A, Gruet A, Witkin M, Kim JH, Shevach E, Krivstov A, ... ... Leslie C, et al. IKZF2 Drives Self-Renewal and Blocks Myeloid Differentiation Programs in Myeloid Leukemic Stem Cells Blood. 132: 3881-3881. DOI: 10.1182/Blood-2018-99-115034  0.422
2018 Prieto C, Nguyen D, Vu LP, Perez A, Gourkanti S, Schurer A, Chou T, Chow A, Taggart J, Barlowe TS, Leslie C, Kharas MG. RNA Binding Protein Rbmx Is Required in Acute Myeloid Leukemia By Regulating the Transcriptional Activity of the Heterochromatin Protein HP1α Blood. 132: 883-883. DOI: 10.1182/Blood-2018-99-112543  0.33
2018 Wesely J, Kotini AG, Georgomanoli M, Luo H, Yuan H, Izzo F, Landau DA, Leslie C, Kharas MG, Papapetrou EP. A Novel iPSC Model Reveals a Role for RUNX1 in the Maintenance of AML Leukemia Stem Cells Blood. 132: 772-772. DOI: 10.1182/Blood-2018-99-111506  0.397
2017 Vu LP, Prieto C, Amin EM, Chhangawala S, Krivtsov A, Calvo-Vidal MN, Chou T, Chow A, Minuesa G, Park SM, Barlowe TS, Taggart J, Tivnan P, Deering RP, Chu LP, ... ... Leslie C, et al. Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nature Genetics. PMID 28436985 DOI: 10.1038/Ng.3854  0.428
2017 Osmanbeyoglu HU, Toska E, Chan C, Baselga J, Leslie CS. Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs. Nature Communications. 8: 14249. PMID 28139702 DOI: 10.1038/Ncomms14249  0.337
2017 Vu L, Prieto C, Amin EM, Minuesa G, Chhangawala S, Vidal MC, Krivtsov A, Chou T, Chow A, Barlowe T, Taggart J, Tivnan P, Deering RP, Chu LP, Gonen M, ... ... Leslie C, et al. Abstract IA13: RNA regulators and the control of self-renewal Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Hemmal17-Ia13  0.445
2017 Osmanbeyoglu HU, Leslie C. Abstract LB-010: Modeling the impact of mutations in ubiquitin pathway genes across human cancers Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-010  0.313
2016 Taggart J, Ho TC, Amin E, Xu H, Barlowe TS, Perez AR, Durham BH, Tivnan P, Okabe R, Chow A, Vu L, Park SM, Prieto C, Famulare C, Patel M, ... ... Leslie C, et al. MSI2 is required for maintaining activated myelodysplastic syndrome stem cells. Nature Communications. 7: 10739. PMID 26898884 DOI: 10.1038/Ncomms10739  0.383
2016 Vu LP, Prieto C, Amin E, Minuesa G, Chhangawala S, Vidal MJ, Krivtsov AV, Chou T, Barlowe T, Taggart J, Tivnan P, Deering RP, Gonen M, Figueroa ME, Paietta E, ... ... Leslie C, et al. RNA Binding Protein Syncrip Regulates the Leukemia Stem Cell Program Blood. 128: 739-739. DOI: 10.1182/Blood.V128.22.739.739  0.433
2016 Toska E, Osmanbeyoglu H, Elkabets M, Chan C, Castel P, Dickler M, Armstrong S, Leslie C, Scaltriti M, José B. Abstract 885: Epigenetic regulation of estrogen receptor transcription by the PI3K pathway in breast cancer Cancer Research. 76: 885-885. DOI: 10.1158/1538-7445.Am2016-885  0.368
2016 Osmanbeyoglu HU, Toska E, Baselga J, Leslie C. Abstract 781: Modeling the impact of somatic alterations across human cancers Cancer Research. 76: 781-781. DOI: 10.1158/1538-7445.Am2016-781  0.364
2015 Zhang L, Tung NT, Su H, Wang R, Lu Y, Tang H, Aoyagi S, Guo A, Khodadadi-Jamayran A, Zhou D, Qian K, Hricik T, Côté J, Han X, Zhou W, ... ... Leslie C, et al. Cross-talk between PRMT1-mediated methylation and ubiquitylation on RBM15 controls RNA splicing. Elife. 4. PMID 26575292 DOI: 10.7554/Elife.07938  0.361
2015 González AJ, Setty M, Leslie CS. Early enhancer establishment and regulatory locus complexity shape transcriptional programs in hematopoietic differentiation. Nature Genetics. PMID 26390058 DOI: 10.1038/ng.3402  0.341
2015 Park SM, Gönen M, Vu L, Minuesa G, Tivnan P, Barlowe TS, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa ME, Paietta E, Fernandez HF, Tallman MS, Melnick A, ... ... Leslie C, et al. Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program. The Journal of Clinical Investigation. 125: 1286-98. PMID 25664853 DOI: 10.1172/Jci78440  0.384
2015 Premsrirut PK, Wang C, Yang Y, Pelossof R, Leslie C, Fellmann C, Dow L, Zuber J, Lowe S. Abstract B37: RNAi and CRISPR/Cas9-based in vivo models for drug discovery Cancer Research. 78: 4188-4188. DOI: 10.1158/1538-7445.Mousemodels17-B37  0.371
2015 Sevenich L, Bowman R, Mason S, Quail D, Rapaport F, Elie B, Brogi E, Brastianos P, Hahn W, Holsinger L, Massagué J, Leslie C, Joyce JA. Abstract IA18: A brain metastasis-promoting role for cathepsin S identified from analysis of tumor- and stroma-supplied proteolytic networks Cancer Research. 75. DOI: 10.1158/1538-7445.Chtme14-Ia18  0.301
2015 Osmanbeyoglu HU, Leslie C. Abstract LB-C04: Modeling the impact of somatic alterations across human cancers Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-Lb-C04  0.4
2014 Park SM, Deering RP, Lu Y, Tivnan P, Lianoglou S, Al-Shahrour F, Ebert BL, Hacohen N, Leslie C, Daley GQ, Lengner CJ, Kharas MG. Musashi-2 controls cell fate, lineage bias, and TGF-β signaling in HSCs. The Journal of Experimental Medicine. 211: 71-87. PMID 24395885 DOI: 10.1084/Jem.20130736  0.339
2014 Park SM, Gönen M, Vu LP, Minuesa G, Tivnan P, Barlowe T, Taggart J, Lu Y, Deering RP, Hacohen N, Figueroa M, Paietta EM, Tallman MS, Melnick AM, Levine RL, ... Leslie C, et al. Msi2 Maintains the MLL Leukemia Stem Cell Regulatory Program Blood. 124: 836-836. DOI: 10.1182/Blood.V124.21.836.836  0.459
2014 Yalcin S, Carty M, Shin JY, Miller RA, Leslie C, Park CY. Microrna Mediated Regulation of Hematopoietic Stem Cell Aging Blood. 124: 602-602. DOI: 10.1182/Blood.V124.21.602.602  0.301
2014 Spitzer B, Guryanova OA, Abdel-Wahab O, Kucine N, Adli M, Berman JN, Meshinchi S, Bernstein B, Pelossof R, Leslie C, Levine RL. Characterizing Transcriptional and Epigenetic Signatures Induced By FLT3-ITD Activation Blood. 124: 2186-2186. DOI: 10.1182/Blood.V124.21.2186.2186  0.426
2013 Kobos R, Nagai M, Tsuda M, Merl MY, Saito T, Laé M, Mo Q, Olshen A, Lianoglou S, Leslie C, Ostrovnaya I, Antczak C, Djaballah H, Ladanyi M. Combining integrated genomics and functional genomics to dissect the biology of a cancer-associated, aberrant transcription factor, the ASPSCR1-TFE3 fusion oncoprotein. The Journal of Pathology. 229: 743-54. PMID 23288701 DOI: 10.1002/Path.4158  0.454
2013 Furman RR, Cheng S, Lu P, Setty M, Perez A, Guo A, Racchumi J, Ma J, Coleman M, Venkataraman K, Xu G, Chen W, Wu H, Chang BY, Leslie C, et al. A Novel Mutation In Bruton Tyrosine Kinase Confers Acquired Resistance To Ibrutinib (PCI-32765) In CLL Blood. 122: 4914-4914. DOI: 10.1182/Blood.V122.21.4914.4914  0.305
2013 Park S, Deering RP, Lu Y, Patrick T, Shenoy V, Lianoglou S, Al-Shahrour F, Leslie C, Ebert BL, Lengner C, Daley GQ, Kharas MG. Msi2 Directly Regulates The TGF-β Signaling Pathway and Myeloid Lineage Bias In Hematopoietic Stem Cells Blood. 122: 468-468. DOI: 10.1182/Blood.V122.21.468.468  0.321
2012 Basso K, Schneider C, Shen Q, Holmes AB, Setty M, Leslie C, Dalla-Favera R. BCL6 positively regulates AID and germinal center gene expression via repression of miR-155. The Journal of Experimental Medicine. 209: 2455-65. PMID 23166356 DOI: 10.1084/Jem.20121387  0.369
2012 Samstein RM, Arvey A, Josefowicz SZ, Peng X, Reynolds A, Sandstrom R, Neph S, Sabo P, Kim JM, Liao W, Li MO, Leslie C, Stamatoyannopoulos JA, Rudensky AY. Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification. Cell. 151: 153-66. PMID 23021222 DOI: 10.1016/J.Cell.2012.06.053  0.367
2012 Arvey A, Agius P, Noble WS, Leslie C. Sequence and chromatin determinants of cell-type-specific transcription factor binding. Genome Research. 22: 1723-34. PMID 22955984 DOI: 10.1101/Gr.127712.111  0.378
2012 Rudra D, deRoos P, Chaudhry A, Niec RE, Arvey A, Samstein RM, Leslie C, Shaffer SA, Goodlett DR, Rudensky AY. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Nature Immunology. 13: 1010-9. PMID 22922362 DOI: 10.1038/Ni.2402  0.412
2012 Arvey A, Tempera I, Tsai K, Chen HS, Tikhmyanova N, Klichinsky M, Leslie C, Lieberman PM. An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Cell Host & Microbe. 12: 233-45. PMID 22901543 DOI: 10.1016/J.Chom.2012.06.008  0.353
2012 Park SM, Deering R, Lu Y, Tivnan P, Shenoy V, Lianoglou S, Al-Shahrour F, Leslie C, Ebert BL, Lengner C, Daley GQ, Kharas MG. Direct RNA Target Analysis Identifies Signatures That Define Msi2's Role in Sustaining HSC Cell Fate. Blood. 120: 2324-2324. DOI: 10.1182/Blood.V120.21.2324.2324  0.423
2011 Papapetrou EP, Lee G, Malani N, Setty M, Riviere I, Tirunagari LM, Kadota K, Roth SL, Giardina P, Viale A, Leslie C, Bushman FD, Studer L, Sadelain M. Genomic safe harbors permit high β-globin transgene expression in thalassemia induced pluripotent stem cells. Nature Biotechnology. 29: 73-8. PMID 21151124 DOI: 10.1038/Nbt.1717  0.403
2011 Sevenich L, Mason S, Rapaport F, Massague J, Leslie C, Joyce J. Abstract 2844: Systems biology analysis of tumor and stromal genes in different metastatic microenvironments Cancer Research. 71: 2844-2844. DOI: 10.1158/1538-7445.Am2011-2844  0.316
2010 Rapaport F, Leslie C. Determining frequent patterns of copy number alterations in cancer. Plos One. 5: e12028. PMID 20711339 DOI: 10.1371/Journal.Pone.0012028  0.319
2010 Li X, Panea C, Wiggins CH, Reinke V, Leslie C. Learning "graph-mer" motifs that predict gene expression trajectories in development. Plos Computational Biology. 6: e1000761. PMID 20454681 DOI: 10.1371/Journal.Pcbi.1000761  0.329
2010 Schneider C, Maute RL, Sumazin P, Brahmachary M, Setty M, Pasqualucci L, Rosolen A, Leslie C, Basso K, Dalla-Favera R. MiR-28 Silencing In Germinal Center-Derived Lymphomas Blood. 116: 703-703. DOI: 10.1182/Blood.V116.21.703.703  0.311
2010 Papapetrou EP, Lee G, Malani N, Setty M, Riviere I, Tirunagari LM, Kadota K, Roth SL, Giardina P, Viale A, Leslie C, Bushman F, Studer L, Sadelain M. Therapeutic Transgene Expression From Genomic Safe Harbors In Patient-Specific Induced Pluripotent Stem Cells Blood. 116: 564-564. DOI: 10.1182/Blood.V116.21.564.564  0.391
2009 Nimrod G, Szilágyi A, Leslie C, Ben-Tal N. Identification of DNA-binding proteins using structural, electrostatic and evolutionary features. Journal of Molecular Biology. 387: 1040-53. PMID 19233205 DOI: 10.1016/J.Jmb.2009.02.023  0.304
2008 Kundaje A, Xin X, Lan C, Lianoglou S, Zhou M, Zhang L, Leslie C. A predictive model of the oxygen and heme regulatory network in yeast. Plos Computational Biology. 4: e1000224. PMID 19008939 DOI: 10.1371/Journal.Pcbi.1000224  0.601
2007 Kundaje A, Lianoglou S, Li X, Quigley D, Arias M, Wiggins CH, Zhang L, Leslie C. Learning regulatory programs that accurately predict differential expression with MEDUSA. Annals of the New York Academy of Sciences. 1115: 178-202. PMID 17934055 DOI: 10.1196/Annals.1407.020  0.634
2006 Kundaje A, Middendorf M, Shah M, Wiggins CH, Freund Y, Leslie C. A classification-based framework for predicting and analyzing gene regulatory response. Bmc Bioinformatics. 7: S5. PMID 16723008 DOI: 10.1186/1471-2105-7-S1-S5  0.632
2005 Kundaje A, Middendorf M, Gao F, Wiggins C, Leslie C. Combining sequence and time series expression data to learn transcriptional modules. Ieee/Acm Transactions On Computational Biology and Bioinformatics / Ieee, Acm. 2: 194-202. PMID 17044183 DOI: 10.1109/Tcbb.2005.34  0.619
2005 Kuang R, Ie E, Wang K, Wang K, Siddiqi M, Freund Y, Leslie C. Profile-based string kernels for remote homology detection and motif extraction. Journal of Bioinformatics and Computational Biology. 3: 527-50. PMID 16108083 DOI: 10.1142/S021972000500120X  0.328
2005 Middendorf M, Kundaje A, Wiggins C, Freund Y, Leslie C. Predicting genetic regulatory response using classification: Yeast stress response Lecture Notes in Bioinformatics (Subseries of Lecture Notes in Computer Science). 3318: 1-13.  0.474
2005 Middendorf M, Kundaje A, Shah M, Freund Y, Wiggins CH, Leslie C. Motif discovery through predictive modeling of gene regulation Lecture Notes in Bioinformatics (Subseries of Lecture Notes in Computer Science). 3500: 538-552.  0.562
2004 Middendorf M, Kundaje A, Wiggins C, Freund Y, Leslie C. Predicting genetic regulatory response using classification. Bioinformatics (Oxford, England). 20: i232-40. PMID 15262804 DOI: 10.1093/bioinformatics/bth923  0.593
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