| Year |
Citation |
Score |
| 2024 |
Getreuer P, Marretta L, Toyoglu E, Dömötör O, Hejl M, Prado-Roller A, Cseh K, Legin AA, Jakupec MA, Barone G, Terenzi A, Keppler BK, Kandioller W. Investigating the anticancer potential of 4-phenylthiazole derived Ru(II) and Os(II) metalacycles. Dalton Transactions (Cambridge, England : 2003). 53: 5567-5579. PMID 38426897 DOI: 10.1039/d4dt00245h |
0.334 |
|
| 2023 |
Maier T, Wutschitz J, Gajic N, Hejl M, Cseh K, Mai S, Jakupec MA, Galanski MS, Keppler BK. Not the usual suspect - an unexpected organometallic product during the synthesis of cytotoxic platinum(II) complexes. Dalton Transactions (Cambridge, England : 2003). PMID 37855721 DOI: 10.1039/d3dt01736b |
0.38 |
|
| 2023 |
Kastner A, Schueffl H, Yassemipour PA, Keppler BK, Heffeter P, Kowol CR. Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes. Angewandte Chemie (International Ed. in English). 62: e202311468. PMID 37703130 DOI: 10.1002/anie.202311468 |
0.339 |
|
| 2023 |
Cseh K, Berasaluce I, Fuchs V, Banc A, Schweikert A, Prado-Roller A, Hejl M, Wernitznig D, Koellensperger G, Jakupec MA, Kandioller W, Malarek MS, Keppler BK. Anticancer Tungstenocenes with a Diverse Set of (-), (,-) and (,-) Chelates-A Detailed Biological Study Using an Improved Evaluation via 3D Spheroid Models. Pharmaceutics. 15. PMID 37514061 DOI: 10.3390/pharmaceutics15071875 |
0.32 |
|
| 2023 |
Kastner A, Mendrina T, Bachmann F, Berger W, Keppler BK, Heffeter P, Kowol CR. Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs. Inorganic Chemistry Frontiers. 10: 4126-4138. PMID 37440920 DOI: 10.1039/d3qi00968h |
0.314 |
|
| 2023 |
Lerchbammer-Kreith Y, Hejl M, Vician P, Jakupec MA, Berger W, Galanski MS, Keppler BK. Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes-A More Selective Anticancer Treatment? Pharmaceutics. 15. PMID 37242758 DOI: 10.3390/pharmaceutics15051515 |
0.318 |
|
| 2023 |
Mészáros JP, Kandioller W, Spengler G, Prado-Roller A, Keppler BK, Enyedy ÉA. Half-Sandwich Rhodium Complexes with Releasable N-Donor Monodentate Ligands: Solution Chemical Properties and the Possibility for Acidosis Activation. Pharmaceutics. 15. PMID 36839678 DOI: 10.3390/pharmaceutics15020356 |
0.316 |
|
| 2022 |
Liu X, Wenisch D, Barth MC, Cseh K, Kowol CR, Jakupec MA, Gibson D, Keppler BK, Weigand W. Novel oxaliplatin(IV) complexes conjugated with ligands bearing pendant 1,2-dithiolane/1,2-diselenolane/cyclopentyl motifs. Dalton Transactions (Cambridge, England : 2003). PMID 36189643 DOI: 10.1039/d2dt02217f |
0.345 |
|
| 2022 |
Liu X, Barth MC, Cseh K, Kowol CR, Jakupec MA, Keppler BK, Gibson D, Weigand W. Oxoplatin-based Pt(IV) lipoate complexes and their biological activity. Chemistry & Biodiversity. PMID 36026613 DOI: 10.1002/cbdv.202200695 |
0.324 |
|
| 2022 |
Pósa V, Hajdu B, Tóth G, Dömötör O, Kowol CR, Keppler BK, Spengler G, Gyurcsik B, Enyedy ÉA. The coordination modes of (thio)semicarbazone copper(II) complexes strongly modulate the solution chemical properties and mechanism of anticancer activity. Journal of Inorganic Biochemistry. 231: 111786. PMID 35287037 DOI: 10.1016/j.jinorgbio.2022.111786 |
0.317 |
|
| 2022 |
Foteeva LS, Nosova YN, Nazarov AA, Keppler BK, Timerbaev AR. Versatile analytical methodology for evaluation of drug-like properties of potentially multi-targeting anticancer metallodrugs. Analytical Sciences : the International Journal of the Japan Society For Analytical Chemistry. PMID 35286638 DOI: 10.1007/s44211-022-00076-9 |
0.352 |
|
| 2022 |
Geisler H, Harringer S, Wenisch D, Urban R, Jakupec MA, Kandioller W, Keppler BK. Systematic Study on the Cytotoxic Potency of Commonly Used Dimeric Metal Precursors in Human Cancer Cell Lines. Chemistryopen. e202200019. PMID 35212190 DOI: 10.1002/open.202200019 |
0.307 |
|
| 2021 |
Riedl CA, Rosner A, Harringer S, Salomon P, Hejl M, Jakupec MA, Kandioller W, Keppler BK. Water-soluble trithiolato-bridged dinuclear ruthenium(II) and osmium(II) arene complexes with bisphosphonate functionalized ligands as anticancer organometallics. Journal of Inorganic Biochemistry. 225: 111618. PMID 34607124 DOI: 10.1016/j.jinorgbio.2021.111618 |
0.33 |
|
| 2021 |
Petrasheuskaya TV, Wernitznig D, Kiss MA, May NV, Wenisch D, Keppler BK, Frank É, Enyedy ÉA. Estrone-salicylaldehyde N-methylated thiosemicarbazone hybrids and their copper complexes: solution structure, stability and anticancer activity in tumour spheroids. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 34453218 DOI: 10.1007/s00775-021-01891-7 |
0.322 |
|
| 2021 |
Enyedy ÉA, Petrasheuskaya TV, Kiss MA, Wernitznig D, Wenisch D, Keppler BK, Spengler G, May NV, Frank É, Dömötör O. Complex formation of an estrone-salicylaldehyde semicarbazone hybrid with copper(II) and gallium(III): Solution equilibria and biological activity. Journal of Inorganic Biochemistry. 220: 111468. PMID 33951554 DOI: 10.1016/j.jinorgbio.2021.111468 |
0.303 |
|
| 2020 |
Mathuber M, Schueffl H, Dömötör O, Karnthaler C, Enyedy ÉA, Heffeter P, Keppler BK, Kowol CR. Improving the Stability of EGFR Inhibitor Cobalt(III) Prodrugs. Inorganic Chemistry. 59: 17794-17810. PMID 33222438 DOI: 10.1021/acs.inorgchem.0c03083 |
0.32 |
|
| 2020 |
Harringer S, Wernitznig D, Gajic N, Diridl A, Wenisch D, Hejl M, Jakupec MA, Theiner S, Koellensperger G, Kandioller W, Keppler BK. Introducing -, -, and -donor leaving groups: an investigation of the chemical and biological properties of ruthenium, rhodium and iridium thiopyridone piano stool complexes. Dalton Transactions (Cambridge, England : 2003). 49: 15693-15711. PMID 33135027 DOI: 10.1039/d0dt03165h |
0.316 |
|
| 2020 |
Hager S, Pape VFS, Pósa V, Montsch B, Uhlik L, Szakács G, Tóth S, Jabronka N, Keppler BK, Kowol CR, Enyedy EA, Heffeter P. High copper complex stability and slow reduction kinetics as key parameters for improved activity, paraptosis induction and impact on drug-resistant cells of anticancer thiosemicarbazones. Antioxidants & Redox Signaling. PMID 32336116 DOI: 10.1089/Ars.2019.7854 |
0.366 |
|
| 2020 |
Mokesch S, Cseh K, Geisler H, Hejl M, Klose MHM, Roller A, Meier-Menches SM, Jakupec MA, Kandioller W, Keppler BK. Investigations on the Anticancer Potential of Benzothiazole-Based Metallacycles. Frontiers in Chemistry. 8: 209. PMID 32318543 DOI: 10.3389/Fchem.2020.00209 |
0.453 |
|
| 2020 |
Foteeva LS, Kuznetsova OV, Keppler BK. How versatile is the use of ultrafiltration to study biointeractions of therapeutic metallodrugs? Analytical Biochemistry. 598: 113697. PMID 32224145 DOI: 10.1016/J.Ab.2020.113697 |
0.316 |
|
| 2020 |
Legina MS, Nogueira JJ, Kandioller W, Jakupec MA, González L, Keppler BK. Biological evaluation of novel thiomaltol-based organometallic complexes as topoisomerase IIα inhibitors. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 32193613 DOI: 10.1007/S00775-020-01775-2 |
0.386 |
|
| 2020 |
Bielec B, Poetsch I, Ahmed E, Heffeter P, Keppler BK, Kowol CR. Reactive Oxygen Species (ROS)-Sensitive Prodrugs of the Tyrosine Kinase Inhibitor Crizotinib. Molecules (Basel, Switzerland). 25. PMID 32143435 DOI: 10.3390/Molecules25051149 |
0.327 |
|
| 2020 |
Ma T, Yang P, Dammann I, Lin Z, Mougharbel AS, Li MX, Adǎscǎliţei F, Mitea R, Silvestru C, Thorstenson C, Ullrich MS, Cseh K, Jakupec MA, Keppler BK, Donalisio M, et al. Tetra-(-tolyl)antimony(III)-Containing Heteropolytungstates, [{(-tolyl)Sb}(-α-XWO)] (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity. Inorganic Chemistry. PMID 32037809 DOI: 10.1021/Acs.Inorgchem.9B03322 |
0.354 |
|
| 2020 |
Harringer S, Happl B, Ozenil M, Kast C, Hejl M, Wernitznig D, Legin AA, Schweikert A, Gajic N, Roller A, Koellensperger G, Jakupec MA, Kandioller W, Keppler BK. Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior. Chemistry (Weinheim An Der Bergstrasse, Germany). 26: 5419-5433. PMID 31958176 DOI: 10.1002/Chem.201905546 |
0.399 |
|
| 2020 |
Geisler H, Wernitznig D, Hejl M, Gajic N, Jakupec MA, Kandioller W, Keppler BK. Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour. Dalton Transactions (Cambridge, England : 2003). 49: 1393-1397. PMID 31950944 DOI: 10.1039/C9Dt04462K |
0.338 |
|
| 2020 |
Hager S, Pape VF, Pósa V, Montsch B, Uhlik L, Szakàcs G, Tóth S, Jabronka N, Keppler BK, Berger W, Kowol CR, Enyedy ÉA, Heffeter P. Abstract 1939: Improved activity and paraptosis-induction of anticancer thiosemicarbazones requires high copper(II) complex stability and slow reduction kinetics Cancer Research. 80: 1939-1939. DOI: 10.1158/1538-7445.Am2020-1939 |
0.441 |
|
| 2020 |
Afanasenko AM, Chulkova TG, Boyarskaya IA, Islamova RM, Legin AA, Keppler BK, Selivanov SI, Vereshchagin AN, Elinson MN, Haukka M. C,N-chelated diaminocarbene platinum(II) complexes derived from 3,4-diaryl-1H-pyrrol-2,5-diimines and cis-dichlorobis(isonitrile)platinum(II): Synthesis, cytotoxicity, and catalytic activity in hydrosilylation reactions Journal of Organometallic Chemistry. 923: 121435. DOI: 10.1016/J.Jorganchem.2020.121435 |
0.425 |
|
| 2020 |
Mészáros JP, Geisler H, Poljarević JM, Roller A, Legina MS, Hejl M, Jakupec MA, Keppler BK, Kandioller W, Enyedy ÉA. Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations Journal of Organometallic Chemistry. 907: 121070. DOI: 10.1016/J.Jorganchem.2019.121070 |
0.431 |
|
| 2020 |
Harringer S, Matzinger M, Gajic N, Hejl M, Jakupec MA, Kandioller W, Keppler BK. First insights into the novel class of organometallic compounds bearing a bidentate selenopyridone coordination motif: Synthesis, characterization, stability and biological investigations Inorganica Chimica Acta. 513: 119919. DOI: 10.1016/J.Ica.2020.119919 |
0.464 |
|
| 2019 |
Rusz M, Rampler E, Keppler BK, Jakupec MA, Koellensperger G. Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids. Metabolites. 9. PMID 31847430 DOI: 10.3390/Metabo9120304 |
0.335 |
|
| 2019 |
Berasaluce I, Cseh K, Roller A, Hejl M, Heffeter P, Berger W, Jakupec MA, Kandioller W, Malarek MS, Keppler BK. The first anticancer tris(pyrazolyl)borate molybdenum(IV) complexes: tested in vitro and in vivo - a comparison of O,O-, S,O-, and N,N-chelate effects. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31560142 DOI: 10.1002/Chem.201903605 |
0.382 |
|
| 2019 |
Galvez L, Rusz M, Schwaiger-Haber M, El Abiead Y, Hermann G, Jungwirth U, Berger W, Keppler BK, Jakupec MA, Koellensperger G. Preclinical studies on metal based anticancer drugs as enabled by integrated metallomics and metabolomics. Metallomics : Integrated Biometal Science. PMID 31497817 DOI: 10.1039/C9Mt00141G |
0.32 |
|
| 2019 |
Hager LA, Mokesch S, Kieler C, Alonso-de Castro S, Baier D, Roller A, Kandioller W, Keppler BK, Berger W, Salassa L, Terenzi A. Ruthenium-arene complexes bearing naphthyl-substituted 1,3-dioxoindan-2-carboxamides ligands for G-quadruplex DNA recognition. Dalton Transactions (Cambridge, England : 2003). PMID 31292575 DOI: 10.1039/C9Dt02078K |
0.421 |
|
| 2019 |
Mokesch S, Schwarz D, Hejl M, Klose MHM, Roller A, Jakupec MA, Kandioller W, Keppler BK. Fine-Tuning the Activation Mode of an 1,3-Indandione-Based Ruthenium(II)-Cymene Half-Sandwich Complex by Variation of Its Leaving Group. Molecules (Basel, Switzerland). 24. PMID 31252521 DOI: 10.3390/Molecules24132373 |
0.417 |
|
| 2019 |
Domarco O, Kieler C, Pirker C, Dinhof C, Englinger B, Reisecker JM, Timelthaler G, García MD, Peinador C, Keppler BK, Berger W, Terenzi A. Subcellular duplex DNA and G-quadruplex interaction profiling of a hexagonal Pt(II) metallacycle. Angewandte Chemie (International Ed. in English). PMID 31002438 DOI: 10.1002/Anie.201900934 |
0.322 |
|
| 2019 |
Wernitznig D, Kiakos K, Del Favero G, Harrer N, Machat H, Osswald A, Jakupec MA, Wernitznig A, Sommergruber W, Keppler BK. First-in-class ruthenium anticancer drug (KP1339/IT-139) induces an immunogenic cell death signature in colorectal spheroids in vitro. Metallomics : Integrated Biometal Science. 11: 1044-1048. PMID 30942231 DOI: 10.1039/C9Mt00051H |
0.364 |
|
| 2019 |
Kastner A, Poetsch I, Mayr J, Burda JV, Roller A, Heffeter P, Keppler BK, Kowol CR. A Dogma in Doubt: Hydrolysis of Equatorial Ligands of Pt Complexes under Physiological Conditions. Angewandte Chemie (International Ed. in English). 58: 7464-7469. PMID 30870571 DOI: 10.1002/Anie.201900682 |
0.403 |
|
| 2019 |
Heffeter P, Pape VFS, Enyedy ÉA, Keppler BK, Szakacs G, Kowol CR. Anticancer Thiosemicarbazones: Chemical Properties, Interaction with Iron Metabolism, and Resistance Development. Antioxidants & Redox Signaling. 30: 1062-1082. PMID 29334758 DOI: 10.1089/Ars.2017.7487 |
0.305 |
|
| 2019 |
Hizal S, Hejl M, Jakupec MA, Galanski M, Keppler BK. Synthesis, characterization, lipophilicity and cytotoxic properties of novel bis(carboxylato)oxalatobis(1-propylamine)platinum(IV) complexes Inorganica Chimica Acta. 491: 76-83. DOI: 10.1016/J.Ica.2019.03.036 |
0.442 |
|
| 2019 |
Höfer D, Cseh K, Hejl M, Roller A, Jakupec MA, Galanski M, Keppler BK. Synthesis, characterization, cytotoxic activity, and 19F NMR spectroscopic investigations of (OC-6-33)-diacetato(ethane-1,2-diamine)bis(3,3,3-trifluoropropanoato)platinum(IV) and its platinum(II) counterpart Inorganica Chimica Acta. 490: 190-199. DOI: 10.1016/J.Ica.2019.02.017 |
0.472 |
|
| 2018 |
Alonso-de Castro S, Terenzi A, Hager S, Englinger B, Faraone A, Martínez JC, Galanski M, Keppler BK, Berger W, Salassa L. Biological activity of Pt prodrugs triggered by riboflavin-mediated bioorthogonal photocatalysis. Scientific Reports. 8: 17198. PMID 30464209 DOI: 10.1038/S41598-018-35655-2 |
0.317 |
|
| 2018 |
Carboni S, Zucca A, Stoccoro S, Maiore L, Arca M, Ortu F, Artner C, Keppler BK, Meier-Menches SM, Casini A, Cinellu MA. New Variations on the Theme of Gold(III) CNN Cyclometalated Complexes as Anticancer Agents: Synthesis and Biological Characterization. Inorganic Chemistry. PMID 30457328 DOI: 10.1021/Acs.Inorgchem.8B02604 |
0.468 |
|
| 2018 |
Kallus S, Uhlik L, van Schoonhoven S, Pelivan K, Berger W, Enyedy ÉA, Hofmann T, Heffeter P, Kowol CR, Keppler BK. Synthesis and biological evaluation of biotin-conjugated anticancer thiosemicarbazones and their iron(III) and copper(II) complexes. Journal of Inorganic Biochemistry. 190: 85-97. PMID 30384010 DOI: 10.1016/J.Jinorgbio.2018.10.006 |
0.461 |
|
| 2018 |
Hager S, Korbula K, Bielec B, Grusch M, Pirker C, Schosserer M, Liendl L, Lang M, Grillari J, Nowikovsky K, Pape VFS, Mohr T, Szakács G, Keppler BK, Berger W, et al. The thiosemicarbazone MeNNMe induces paraptosis by disrupting the ER thiol redox homeostasis based on protein disulfide isomerase inhibition. Cell Death & Disease. 9: 1052. PMID 30323190 DOI: 10.1038/S41419-018-1102-Z |
0.344 |
|
| 2018 |
Klose MHM, Schöberl A, Heffeter P, Berger W, Hartinger CG, Koellensperger G, Meier-Menches SM, Keppler BK. Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS. Monatshefte Fur Chemie. 149: 1719-1726. PMID 30237619 DOI: 10.1007/S00706-018-2280-1 |
0.367 |
|
| 2018 |
Galvez L, Theiner S, Grabarics M, Kowol CR, Keppler BK, Hann S, Koellensperger G. Critical assessment of different methods for quantitative measurement of metallodrug-protein associations. Analytical and Bioanalytical Chemistry. PMID 30155703 DOI: 10.1007/S00216-018-1328-8 |
0.315 |
|
| 2018 |
Kallus S, Englinger B, Senkiv J, Laemmerer A, Heffeter P, Berger W, Kowol CR, Keppler BK. Nanoformulations of anticancer FGFR inhibitors with improved therapeutic index. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 30121385 DOI: 10.1016/J.Nano.2018.08.001 |
0.302 |
|
| 2018 |
Nazarov AA, Mendoza-Ferri MG, Hanif M, Keppler BK, Dyson PJ, Hartinger CG. Understanding the interactions of diruthenium anticancer agents with amino acids. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 30046902 DOI: 10.1007/S00775-018-1597-X |
0.405 |
|
| 2018 |
Streciwilk W, Terenzi A, Cheng X, Hager L, Dabiri Y, Prochnow P, Bandow JE, Wölfl S, Keppler BK, Ott I. Fluorescent organometallic rhodium(I) and ruthenium(II) metallodrugs with 4-ethylthio-1,8-naphthalimide ligands: Antiproliferative effects, cellular uptake and DNA-interaction. European Journal of Medicinal Chemistry. 156: 148-161. PMID 30006161 DOI: 10.1016/J.Ejmech.2018.06.056 |
0.393 |
|
| 2018 |
Frensemeier LM, Mayr J, Koellensperger G, Keppler BK, Kowol CR, Karst U. Structure elucidation and quantification of the reduction products of anticancer Pt(IV) prodrugs by electrochemistry/mass spectrometry (EC-MS) Analyst. 143: 1997-2001. PMID 29629473 DOI: 10.1039/C8An00258D |
0.342 |
|
| 2018 |
Theiner S, Grabarics M, Galvez L, Varbanov HP, Sommerfeld NS, Galanski M, Keppler BK, Koellensperger G. The impact of whole human blood on the kinetic inertness of platinum(iv) prodrugs - an HPLC-ICP-MS study. Dalton Transactions (Cambridge, England : 2003). PMID 29560976 DOI: 10.1039/C7Dt04537A |
0.419 |
|
| 2018 |
Riedl CA, Hejl M, Klose MHM, Roller A, Jakupec MA, Kandioller W, Keppler BK. N- and S-donor leaving groups in triazole-based ruthena(ii)cycles: potent anticancer activity, selective activation, and mode of action studies. Dalton Transactions (Cambridge, England : 2003). 47: 4625-4638. PMID 29520401 DOI: 10.1039/C8Dt00449H |
0.426 |
|
| 2018 |
Pelivan K, Frensemeier LM, Karst U, Koellensperger G, Heffeter P, Keppler BK, Kowol CR. Comparison of metabolic pathways of different α-N-heterocyclic thiosemicarbazones. Analytical and Bioanalytical Chemistry. 410: 2343-2361. PMID 29476231 DOI: 10.1007/S00216-018-0889-X |
0.308 |
|
| 2018 |
Babak MV, Pfaffeneder-Kmen M, Meier-Menches SM, Legina MS, Theiner S, Licona C, Orvain C, Hejl M, Hanif M, Jakupec MA, Keppler BK, Gaiddon C, Hartinger CG. Rollover Cyclometalated Bipyridine Platinum Complexes as Potent Anticancer Agents: Impact of the Ancillary Ligands on the Mode of Action. Inorganic Chemistry. 57: 2851-2864. PMID 29442506 DOI: 10.1021/Acs.Inorgchem.7B03210 |
0.432 |
|
| 2018 |
Meier-Menches SM, Gerner C, Berger W, Hartinger CG, Keppler BK. Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development. Chemical Society Reviews. 47: 909-928. PMID 29170783 DOI: 10.1039/C7Cs00332C |
0.332 |
|
| 2018 |
Pashkunova-Martic I, Losantos BC, Kandler N, Keppler B. Studies of KP46 and KP1019 and the hydrolysis product of KP1019 in lipiodol emulsions: preparation and initial characterizations as potential theragnostic agents. Current Drug Delivery. 15: 134-142. PMID 28000552 DOI: 10.2174/1567201813666161220153702 |
0.398 |
|
| 2018 |
Wernitznig D, Favero GD, Kiakos K, Harrer N, Machat H, Marko D, Jakupec M, Sommergruber W, Keppler BK. Abstract 4395: KP-1339 (IT-139) induces the hallmarks of immunogenic cell death in a colon cancer 3D model in vitro Cancer Research. 78: 4395-4395. DOI: 10.1158/1538-7445.Am2018-4395 |
0.323 |
|
| 2018 |
Mészáros JP, Dömötör O, Hackl CM, Roller A, Keppler BK, Kandioller W, Enyedy EAA. Structural and solution equilibrium studies on half-sandwich organorhodium complexes of (N,N) donor bidentate ligands New Journal of Chemistry. 42: 11174-11184. DOI: 10.1039/C8Nj01681J |
0.408 |
|
| 2018 |
Kandioller W, Reikersdorfer M, Theiner S, Roller A, Hejl M, Jakupec MA, Malarek MS, Keppler BK. The Impact of Leaving Group Variation on the Anticancer Activity of Molybdenocenes Organometallics. 37: 3909-3916. DOI: 10.1021/Acs.Organomet.8B00582 |
0.341 |
|
| 2018 |
Streciwilk W, Terenzi A, Lo Nardo F, Prochnow P, Bandow JE, Keppler BK, Ott I. Synthesis and Biological Evaluation of Organometallic Complexes Bearing Bis-1,8-naphthalimide Ligands European Journal of Inorganic Chemistry. 2018: 3104-3112. DOI: 10.1002/Ejic.201800384 |
0.387 |
|
| 2017 |
Hanif M, Meier SM, Adhireksan Z, Henke H, Martic S, Movassaghi S, Labib M, Kandioller W, Jamieson SMF, Hejl M, Jakupec MA, Kraatz HB, Davey CA, Keppler BK, Hartinger CG. Functionalization of Ruthenium(II)(η -p-cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies. Chempluschem. 82: 841-847. PMID 31961568 DOI: 10.1002/Cplu.201700050 |
0.438 |
|
| 2017 |
Bonsignore R, Russo F, Terenzi A, Spinello A, Lauria A, Gennaro G, Almerico AM, Keppler BK, Barone G. The interaction of Schiff Base complexes of nickel(II) and zinc(II) with duplex and G-quadruplex DNA. Journal of Inorganic Biochemistry. 178: 106-114. PMID 29128495 DOI: 10.1016/J.Jinorgbio.2017.10.010 |
0.385 |
|
| 2017 |
Theiner S, Van Malderen SJM, Van Acker T, Legin A, Keppler BK, Vanhaecke F, Koellensperger G. Fast High-Resolution Laser Ablation-Inductively Coupled Plasma Mass Spectrometry Imaging of the Distribution of Platinum-Based Anticancer Compounds in Multicellular Tumor Spheroids. Analytical Chemistry. 89: 12641-12645. PMID 29105484 DOI: 10.1021/Acs.Analchem.7B02681 |
0.32 |
|
| 2017 |
Hackl CM, Schoenhacker-Alte B, Klose MHM, Henke H, Legina MS, Jakupec MA, Berger W, Keppler BK, Brüggemann O, Teasdale I, Heffeter P, Kandioller W. Synthesis and in vivo anticancer evaluation of poly(organo)phosphazene-based metallodrug conjugates. Dalton Transactions (Cambridge, England : 2003). PMID 28862707 DOI: 10.1039/C7Dt01767G |
0.413 |
|
| 2017 |
Nosova YN, Zenin IV, Maximova VP, Zhidkova EM, Kirsanov KI, Lesovaya EA, Lobas AA, Gorshkov MV, Kovaleva ON, Milaeva ER, Galanski M, Keppler BK, Nazarov AA. Influence of the Number of Axial Bexarotene Ligands on the Cytotoxicity of Pt(IV) Analogs of Oxaliplatin. Bioinorganic Chemistry and Applications. 2017: 4736321. PMID 28804273 DOI: 10.1155/2017/4736321 |
0.422 |
|
| 2017 |
Pelivan K, Frensemeier L, Karst U, Koellensperger G, Bielec B, Hager S, Heffeter P, Keppler BK, Kowol CR. Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS. The Analyst. 142: 3165-3176. PMID 28745337 DOI: 10.1039/C7An00902J |
0.312 |
|
| 2017 |
Platzer S, Leyma R, Wolske S, Kandioller W, Heid E, Schröder C, Schagerl M, Krachler R, Jirsa F, Keppler BK. Thioglycolate-based task-specific ionic liquids: Metal extraction abilities vs acute algal toxicity. Journal of Hazardous Materials. 340: 113-119. PMID 28711828 DOI: 10.1016/J.Jhazmat.2017.06.053 |
0.306 |
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| 2017 |
Höfer D, Varbanov HP, Hejl M, Jakupec MA, Roller A, Galanski M, Keppler BK. Impact of the equatorial coordination sphere on the rate of reduction, lipophilicity and cytotoxic activity of platinum(IV) complexes. Journal of Inorganic Biochemistry. 174: 119-129. PMID 28666155 DOI: 10.1016/J.Jinorgbio.2017.06.005 |
0.468 |
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| 2017 |
Varbanov HP, Ortiz D, Höfer D, Menin L, Galanski M, Keppler BK, Dyson PJ. Oxaliplatin reacts with DMSO only in the presence of water. Dalton Transactions (Cambridge, England : 2003). PMID 28654098 DOI: 10.1039/C7Dt01628J |
0.306 |
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| 2017 |
Klose MHM, Hejl M, Heffeter P, Jakupec MA, Meier-Menches SM, Berger W, Keppler BK. Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue. The Analyst. PMID 28585637 DOI: 10.1039/C7An00350A |
0.309 |
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| 2017 |
Meier SM, Kreutz D, Winter L, Klose MHM, Cseh K, Weiss T, Bileck A, Alte B, Mader JC, Jana S, Chatterjee A, Bhattacharyya A, Hejl M, Jakupec MA, Heffeter P, ... ... Keppler BK, et al. An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin. Angewandte Chemie (International Ed. in English). PMID 28547791 DOI: 10.1002/Anie.201702242 |
0.3 |
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| 2017 |
Mayr J, Heffeter P, Groza D, Galvez L, Koellensperger G, Roller A, Alte B, Haider M, Berger W, Kowol CR, Keppler BK. An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo. Chemical Science. 8: 2241-2250. PMID 28507680 DOI: 10.1039/C6Sc03862J |
0.412 |
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| 2017 |
Mayr J, Hager S, Koblmüller B, Klose MH, Holste K, Fischer B, Pelivan K, Berger W, Heffeter P, Kowol CR, Keppler BK. EGFR-targeting peptide-coupled platinum(IV) complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 28405842 DOI: 10.1007/S00775-017-1450-7 |
0.322 |
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| 2017 |
Tamasi G, Merlino A, Scaletti F, Heffeter P, Legin AA, Jakupec MA, Berger W, Messori L, Keppler BK, Cini R. {Ru(CO)x}-Core complexes with benzimidazole ligands: synthesis, X-ray structure and evaluation of anticancer activity in vivo. Dalton Transactions (Cambridge, England : 2003). PMID 28207024 DOI: 10.1039/C6Dt04295C |
0.43 |
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| 2017 |
Göschl S, Schreiber-Brynzak E, Pichler V, Cseh K, Heffeter P, Jungwirth U, Jakupec MA, Berger W, Keppler BK. Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models. Metallomics : Integrated Biometal Science. PMID 28205649 DOI: 10.1039/C6Mt00226A |
0.432 |
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| 2017 |
Blazevic A, Hummer AA, Heffeter P, Berger W, Filipits M, Cibin G, Keppler BK, Rompel A. Electronic State of Sodium trans-[Tetrachloridobis(1H-indazole)ruthenate(III)] (NKP-1339) in Tumor, Liver and Kidney Tissue of a SW480-bearing Mouse. Scientific Reports. 7: 40966. PMID 28112202 DOI: 10.1038/Srep40966 |
0.411 |
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| 2017 |
Riedl CA, Flocke LS, Hejl M, Roller A, Klose MH, Jakupec MA, Kandioller W, Keppler BK. Introducing the 4-Phenyl-1,2,3-Triazole Moiety as a Versatile Scaffold for the Development of Cytotoxic Ruthenium(II) and Osmium(II) Arene Cyclometalates. Inorganic Chemistry. 56: 528-541. PMID 27996251 DOI: 10.1021/Acs.Inorgchem.6B02430 |
0.432 |
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| 2017 |
Orlowska E, Roller A, Pignitter M, Jirsa F, Krachler R, Kandioller W, Keppler BK. Synthetic iron complexes as models for natural iron-humic compounds: Synthesis, characterization and algal growth experiments. The Science of the Total Environment. 577: 94-104. PMID 27810305 DOI: 10.1016/J.Scitotenv.2016.10.109 |
0.36 |
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| 2017 |
Orlowska E, Enyedy ÉA, Pignitter M, Jirsa F, Krachler R, Kandioller W, Keppler BK. β-O-4 type dilignol compounds and their iron complexes for modeling of iron binding to humic acids: synthesis, characterization, electrochemical studies and algal growth experiments New Journal of Chemistry. 41: 11546-11555. DOI: 10.1039/C7Nj02328F |
0.386 |
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| 2017 |
Bolotin DS, Demakova MY, Legin AA, Suslonov VV, Nazarov AA, Jakupec MA, Keppler BK, Kukushkin VY. Amidoxime platinum( ii ) complexes: pH-dependent highly selective generation and cytotoxic activity New Journal of Chemistry. 41: 6840-6848. DOI: 10.1039/C7Nj00982H |
0.443 |
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| 2017 |
Dömötör O, Hackl CM, Bali K, Roller A, Hejl M, Jakupec MA, Keppler BK, Kandioller W, Enyedy ÉA. Comparative equilibrium and structural studies of new pentamethylcyclopentadienyl rhodium complexes bearing (O,N) donor bidentate ligands Journal of Organometallic Chemistry. 846: 287-295. DOI: 10.1016/J.Jorganchem.2017.06.027 |
0.421 |
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| 2017 |
Jakusch T, Kozma K, Enyedy ÉA, May NV, Roller A, Kowol CR, Keppler BK, Kiss T. Complexes of pyridoxal thiosemicarbazones formed with vanadium(IV/V) and copper(II): Solution equilibrium and structure Inorganica Chimica Acta. 472: 243-253. DOI: 10.1016/J.Ica.2017.08.018 |
0.359 |
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| 2017 |
Dömötör O, May NV, Pelivan K, Kiss T, Keppler BK, Kowol CR, Enyedy ÉA. A comparative study of α-N-pyridyl thiosemicarbazones: Spectroscopic properties, solution stability and copper(II) complexation Inorganica Chimica Acta. 472: 264-275. DOI: 10.1016/J.Ica.2017.07.001 |
0.376 |
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| 2017 |
Sommerfeld NS, Strohhofer D, Cseh K, Theiner S, Jakupec MA, Koellensperger G, Galanski M, Keppler BK. Platinum(IV) Complexes Featuring Axial Michael Acceptor Ligands – Synthesis, Characterization, and Cytotoxicity European Journal of Inorganic Chemistry. 2017: 4049-4054. DOI: 10.1002/Ejic.201700753 |
0.436 |
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| 2017 |
Sommerfeld NS, Gülzow J, Roller A, Cseh K, Jakupec MA, Grohmann A, Galanski M, Keppler BK. Antiproliferative Copper(II) and Platinum(II) Complexes with Bidentate N,N‐Donor Ligands European Journal of Inorganic Chemistry. 2017: 3115-3124. DOI: 10.1002/Ejic.201700416 |
0.388 |
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| 2017 |
Höfer D, Galanski M, Keppler BK. Synthesis, Characterization, and Time‐Dependent NMR Spectroscopy Studies of (SP‐4‐2)‐[(trans‐1R,2R/1S,2S‐15N2)‐Cyclohexane‐1,2‐diamine][(13C2)oxalato]platinum(II) European Journal of Inorganic Chemistry. 2017: 2347-2354. DOI: 10.1002/Ejic.201601503 |
0.315 |
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| 2017 |
Nosova YN, Foteeva LS, Zenin IV, Fetisov TI, Kirsanov KI, Yakubovskaya MG, Antonenko TA, Tafeenko VA, Aslanov LA, Lobas AA, Gorshkov MV, Galanski M, Keppler BK, Timerbaev AR, Milaeva ER, et al. Enhancing the cytotoxic activity of anticancer Pt(IV) complexes by introduction of lonidamine as an axial ligand European Journal of Inorganic Chemistry. 2017: 1785-1791. DOI: 10.1002/Ejic.201600857 |
0.431 |
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| 2017 |
Hanif M, Meier SM, Adhireksan Z, Henke H, Martic S, Movassaghi S, Labib M, Kandioller W, Jamieson SMF, Hejl M, Jakupec MA, Kraatz H, Davey CA, Keppler BK, Hartinger CG. Back Cover: Functionalization of Ruthenium(II)(η6
-p
-cymene)(3-hydroxy-2-pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies (ChemPlusChem 6/2017) Chempluschem. 82. DOI: 10.1002/Cplu.201700176 |
0.374 |
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| 2016 |
Legin AA, Theiner S, Schintlmeister A, Reipert S, Heffeter P, Jakupec MA, Mayr J, Varbanov HP, Kowol CR, Galanski M, Berger W, Wagner M, Keppler BK. Multi-scale imaging of anticancer platinum(iv) compounds in murine tumor and kidney. Chemical Science. 7: 3052-3061. PMID 29997796 DOI: 10.1039/C5Sc04383B |
0.305 |
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| 2016 |
Streciwilk W, Terenzi A, Misgeld R, Frias C, Jones PG, Prokop A, Keppler B, Ott I. Metal NHC Complexes with Naphthalimide Ligands as DNA-Interacting Antiproliferative Agents. Chemmedchem. PMID 27997743 DOI: 10.1002/Cmdc.201600557 |
0.392 |
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| 2016 |
Platzer S, Kar M, Leyma R, Chib S, Roller A, Jirsa F, Krachler R, MacFarlane DR, Kandioller W, Keppler BK. Task-specific thioglycolate ionic liquids for heavy metal extraction: Synthesis, extraction efficacies and recycling properties. Journal of Hazardous Materials. PMID 27856054 DOI: 10.1016/J.Jhazmat.2016.10.054 |
0.311 |
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| 2016 |
Hackl CM, Legina MS, Pichler V, Schmidlehner M, Roller A, Dömötör O, Enyedy EA, Jakupec MA, Kandioller W, Keppler BK. Thiomaltol-Based Organometallic Complexes with 1-Methylimidazole as Leaving Group: Synthesis, Stability, and Biological Behavior. Chemistry (Weinheim An Der Bergstrasse, Germany). 22: 17269-17281. PMID 27759173 DOI: 10.1002/Chem.201603206 |
0.421 |
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| 2016 |
Karnthaler-Benbakka C, Groza D, Koblmüller B, Terenzi A, Holste K, Haider M, Baier D, Berger W, Heffeter P, Kowol CR, Keppler BK. Targeting a Targeted Drug: An Approach Toward Hypoxia-Activatable Tyrosine Kinase Inhibitor Prodrugs. Chemmedchem. PMID 27706901 DOI: 10.1002/Cmdc.201600417 |
0.305 |
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| 2016 |
Terenzi A, Pirker C, Keppler BK, Berger W. Anticancer metal drugs and immunogenic cell death. Journal of Inorganic Biochemistry. PMID 27350082 DOI: 10.1016/J.Jinorgbio.2016.06.021 |
0.344 |
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| 2016 |
Kowol CR, Miklos W, Pfaff S, Hager S, Kallus S, Pelivan K, Kubanik M, Enyedy EA, Berger W, Heffeter P, Keppler BK. Impact of stepwise NH2-methylation of Triapine on the physico-chemical properties, anticancer activity and resistance circumvention. Journal of Medicinal Chemistry. PMID 27336684 DOI: 10.1021/Acs.Jmedchem.6B00342 |
0.351 |
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| 2016 |
Bonsignore R, Terenzi A, Spinello A, Martorana A, Lauria A, Almerico AM, Keppler BK, Barone G. G-quadruplex vs. duplex-DNA binding of nickel(II) and zinc(II) Schiff base complexes. Journal of Inorganic Biochemistry. PMID 27230387 DOI: 10.1016/J.Jinorgbio.2016.05.010 |
0.367 |
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| 2016 |
Kubanik M, Kandioller W, Kim K, Anderson RF, Klapproth E, Jakupec MA, Roller A, Söhnel T, Keppler BK, Hartinger CG. Towards targeting anticancer drugs: ruthenium(ii)-arene complexes with biologically active naphthoquinone-derived ligand systems. Dalton Transactions (Cambridge, England : 2003). PMID 27214822 DOI: 10.1039/C6Dt01110A |
0.476 |
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| 2016 |
Bijelic A, Theiner S, Keppler BK, Rompel A. X-ray Structure Analysis of Indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) Bound to Human Serum Albumin Reveals Two Ruthenium Binding Sites and Provides Insights into the Drug Binding Mechanism. Journal of Medicinal Chemistry. 59: 5894-903. PMID 27196130 DOI: 10.1021/Acs.Jmedchem.6B00600 |
0.388 |
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| 2016 |
Henke H, Kryeziu K, Banfić J, Theiner S, Körner W, Brüggemann O, Berger W, Keppler BK, Heffeter P, Teasdale I. Macromolecular Pt(IV) Prodrugs from Poly(organo)phosphazenes. Macromolecular Bioscience. 16: 1239-1249. PMID 27169668 DOI: 10.1002/Mabi.201600035 |
0.372 |
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| 2016 |
Göschl S, Varbanov HP, Theiner S, Jakupec MA, Galanski M, Keppler BK. The role of the equatorial ligands for the redox behavior, mode of cellular accumulation and cytotoxicity of platinum(IV) prodrugs. Journal of Inorganic Biochemistry. 160: 264-74. PMID 27055943 DOI: 10.1016/J.Jinorgbio.2016.03.005 |
0.424 |
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| 2016 |
Terenzi A, Lötsch D, van Schoonhoven S, Roller A, Kowol CR, Berger W, Keppler BK, Barone G. Another step toward DNA selective targeting: Ni(II) and Cu(II) complexes of a Schiff base ligand able to bind gene promoter G-quadruplexes. Dalton Transactions (Cambridge, England : 2003). 45: 7758-67. PMID 27054617 DOI: 10.1039/C6Dt00648E |
0.392 |
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| 2016 |
Bytzek AK, Koellensperger G, Keppler BK, G Hartinger C. Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action. Journal of Inorganic Biochemistry. 160: 250-5. PMID 26993078 DOI: 10.1016/J.Jinorgbio.2016.02.037 |
0.344 |
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| 2016 |
Flocke LS, Trondl R, Jakupec MA, Keppler BK. Molecular mode of action of NKP-1339 - a clinically investigated ruthenium-based drug - involves ER- and ROS-related effects in colon carcinoma cell lines. Investigational New Drugs. 34: 261-8. PMID 26988975 DOI: 10.1007/S10637-016-0337-8 |
0.321 |
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| 2016 |
Novak MS, Büchel GE, Keppler BK, Jakupec MA. Biological properties of novel ruthenium- and osmium-nitrosyl complexes with azole heterocycles. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 26961253 DOI: 10.1007/S00775-016-1345-Z |
0.422 |
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| 2016 |
Meier SM, Gerner C, Keppler BK, Cinellu MA, Casini A. Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects. Inorganic Chemistry. 55: 4248-59. PMID 26866307 DOI: 10.1021/Acs.Inorgchem.5B03000 |
0.397 |
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| 2016 |
Schreiber-Brynzak E, Pichler V, Heffeter P, Hanson B, Theiner S, Lichtscheidl-Schultz I, Kornauth C, Bamonti L, Dhery V, Groza D, Berry D, Berger W, Galanski M, Jakupec MA, Keppler BK. Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation. Metallomics : Integrated Biometal Science. 8: 422-33. PMID 26860208 DOI: 10.1039/C5Mt00312A |
0.403 |
|
| 2016 |
Theiner S, Schreiber-Brynzak E, Jakupec MA, Galanski M, Koellensperger G, Keppler BK. LA-ICP-MS imaging in multicellular tumor spheroids - a novel tool in the preclinical development of metal-based anticancer drugs. Metallomics : Integrated Biometal Science. 8: 398-402. PMID 26806253 DOI: 10.1039/C5Mt00276A |
0.345 |
|
| 2016 |
Schmidlehner M, Flocke LS, Roller A, Hejl M, Jakupec MA, Kandioller W, Keppler BK. Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics. Dalton Transactions (Cambridge, England : 2003). 45: 724-33. PMID 26630201 DOI: 10.1039/C5Dt02722E |
0.464 |
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| 2016 |
Pichler V, Göschl S, Schreiber-Brynzak E, Jakupec MA, Galanski M, Keppler BK. Influence of reducing agents on the cytotoxic activity of platinum(IV) complexes: induction of G2/M arrest, apoptosis and oxidative stress in A2780 and cisplatin resistant A2780cis cell lines. Metallomics : Integrated Biometal Science. 7: 1078-90. PMID 26073554 DOI: 10.1039/C5Mt00116A |
0.409 |
|
| 2016 |
Fischer B, Kryeziu K, Kallus S, Heffeter P, Berger W, Kowol CR, Keppler BK. Nanoformulations of anticancer thiosemicarbazones to reduce methemoglobin formation and improve anticancer activity Rsc Advances. 6: 55848-55859. DOI: 10.1039/C6Ra07659A |
0.317 |
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| 2016 |
Koellensperger G, Galanski M, Keppler BK, Hann S. Turbulent flow chromatography in combination with HPLC-ICP-MS for high-throughput analysis of free, intact metal based drugs in biomedical samples Journal of Analytical Atomic Spectrometry. 31: 1811-1817. DOI: 10.1039/C6Ja00108D |
0.326 |
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| 2016 |
Orlowska E, Roller A, Wiesinger H, Pignitter M, Jirsa F, Krachler R, Kandioller W, Keppler BK. Benzoic hydroxamate-based iron complexes as model compounds for humic substances: synthesis, characterization and algal growth experiments Rsc Advances. 6: 40238-40249. DOI: 10.1039/C5Ra25256C |
0.388 |
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| 2016 |
Galanski M, Sommerfeld N, Hejl M, Klose M, Schreiber-Brynzak E, Bileck A, Meier S, Gerner C, Jakupec M, Keppler B. Low generation PAMAM dendrimers as drug carriers for Pt(IV) complexes European Journal of Inorganic Chemistry. DOI: 10.1002/Ejic.201601205 |
0.351 |
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| 2016 |
Kurzwernhart A, Mokesch S, Klapproth E, Adib‐Ravazi MS, Jakupec MA, Hartinger CG, Kandioller W, Keppler BK. Flavonoid‐Based Organometallics with Different Metal Centers – Investigations of the Effects on Reactivity and Cytotoxicity European Journal of Inorganic Chemistry. 2016: 240-246. DOI: 10.1002/Ejic.201501020 |
0.422 |
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| 2015 |
Babak MV, Meier SM, Huber KVM, Reynisson J, Legin AA, Jakupec MA, Roller A, Stukalov A, Gridling M, Bennett KL, Colinge J, Berger W, Dyson PJ, Superti-Furga G, Keppler BK, et al. Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action. Chemical Science. 6: 2449-2456. PMID 29308157 DOI: 10.1039/C4Sc03905J |
0.34 |
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| 2015 |
Oehninger L, Spreckelmeyer S, Holenya P, Meier SM, Can S, Alborzinia H, Schur J, Keppler BK, Wölfl S, Ott I. Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling. Journal of Medicinal Chemistry. 58: 9591-9600. PMID 26595649 DOI: 10.1021/Acs.Jmedchem.5B01159 |
0.428 |
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| 2015 |
Pelivan K, Miklos W, van Schoonhoven S, Koellensperger G, Gille L, Berger W, Heffeter P, Kowol CR, Keppler BK. Differences in protein binding and excretion of Triapine and its Fe(III) complex. Journal of Inorganic Biochemistry. PMID 26507768 DOI: 10.1016/J.Jinorgbio.2015.10.006 |
0.355 |
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| 2015 |
Höfer D, Varbanov HP, Legin A, Jakupec MA, Roller A, Galanski M, Keppler BK. Tetracarboxylatoplatinum(IV) complexes featuring monodentate leaving groups - A rational approach toward exploiting the platinum(IV) prodrug strategy. Journal of Inorganic Biochemistry. 153: 259-271. PMID 26365319 DOI: 10.1016/J.Jinorgbio.2015.08.018 |
0.482 |
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| 2015 |
Enyedy ÉA, Mészáros JP, Dömötör O, Hackl CM, Roller A, Keppler BK, Kandioller W. Comparative solution equilibrium studies on pentamethylcyclopentadienyl rhodium complexes of 2,2'-bipyridine and ethylenediamine and their interaction with human serum albumin. Journal of Inorganic Biochemistry. 152: 93-103. PMID 26364131 DOI: 10.1016/J.Jinorgbio.2015.08.025 |
0.439 |
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| 2015 |
Kowol CR, Nagy NV, Jakusch T, Roller A, Heffeter P, Keppler BK, Enyedy ÉA. Vanadium(IV/V) complexes of Triapine and related thiosemicarbazones: Synthesis, solution equilibrium and bioactivity. Journal of Inorganic Biochemistry. 152: 62-73. PMID 26349014 DOI: 10.1016/J.Jinorgbio.2015.08.023 |
0.432 |
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| 2015 |
Schreiber-Brynzak E, Klapproth E, Unger C, Lichtscheidl-Schultz I, Göschl S, Schweighofer S, Trondl R, Dolznig H, Jakupec MA, Keppler BK. Three-dimensional and co-culture models for preclinical evaluation of metal-based anticancer drugs. Investigational New Drugs. 33: 835-47. PMID 26091914 DOI: 10.1007/S10637-015-0260-4 |
0.309 |
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| 2015 |
Habala L, Bartel C, Giester G, Jakupec MA, Keppler BK, Rompel A. Complexes of N-hydroxyethyl-N-benzimidazolylmethylethylenediaminediacetic acid with group 12 metals and vanadium-Synthesis, structure and bioactivity of the vanadium complex. Journal of Inorganic Biochemistry. 147: 147-52. PMID 25920686 DOI: 10.1016/J.Jinorgbio.2015.04.004 |
0.455 |
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| 2015 |
Hoffmeister BR, Hejl M, Adib-Razavi MS, Jakupec MA, Galanski M, Keppler BK. Bis- and Tetrakis(carboxylato)platinum(IV) complexes with mixed axial ligands - synthesis, characterization, and cytotoxicity. Chemistry & Biodiversity. 12: 559-574. PMID 25879501 DOI: 10.1002/Cbdv.201400291 |
0.443 |
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| 2015 |
Theiner S, Kornauth C, Varbanov HP, Galanski M, Van Schoonhoven S, Heffeter P, Berger W, Egger AE, Keppler BK. Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(IV)-based anticancer agents. Metallomics : Integrated Biometal Science. 7: 1256-64. PMID 25856224 DOI: 10.1039/C5Mt00028A |
0.309 |
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| 2015 |
Babak MV, Plażuk D, Meier SM, Arabshahi HJ, Reynisson J, Rychlik B, Błauż A, Szulc K, Hanif M, Strobl S, Roller A, Keppler BK, Hartinger CG. Half-sandwich ruthenium(II) biotin conjugates as biological vectors to cancer cells. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 5110-7. PMID 25676245 DOI: 10.1002/Chem.201403974 |
0.445 |
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| 2015 |
Theiner S, Varbanov HP, Galanski M, Egger AE, Berger W, Heffeter P, Keppler BK. Comparative in vitro and in vivo pharmacological investigation of platinum(IV) complexes as novel anticancer drug candidates for oral application. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 20: 89-99. PMID 25413442 DOI: 10.1007/S00775-014-1214-6 |
0.396 |
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| 2015 |
Enyedy ÉA, Dömötör O, Bali K, Hetényi A, Tuccinardi T, Keppler BK. Interaction of the anticancer gallium(III) complexes of 8-hydroxyquinoline and maltol with human serum proteins. Journal of Biological Inorganic Chemistry. 20: 77-88. PMID 25398250 DOI: 10.1007/S00775-014-1211-9 |
0.402 |
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| 2015 |
Kuhn PS, Pichler V, Roller A, Hejl M, Jakupec MA, Kandioller W, Keppler BK. Improved reaction conditions for the synthesis of new NKP-1339 derivatives and preliminary investigations on their anticancer potential. Dalton Transactions (Cambridge, England : 2003). 44: 659-68. PMID 25385191 DOI: 10.1039/C4Dt01645A |
0.416 |
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| 2015 |
Kubanik M, Tu JKY, Söhnel T, Hejl M, Jakupec MA, Kandioller W, Keppler BK, Hartinger CG. Expanding on the Structural Diversity of Flavone- Derived RutheniumII(ƞ6-arene) Anticancer Agents Metallodrugs. 1. DOI: 10.1515/MEDR-2015-0001 |
0.367 |
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| 2015 |
Miklos W, Pelivan K, Kowol C, Dornetshuber-Fleiss R, Spitzwieser M, Cichna-Markl M, Köllensperger G, Keppler B, Berger W, Heffeter P. Abstract 5461: Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance Cancer Research. 75: 5461-5461. DOI: 10.1158/1538-7445.Am2015-5461 |
0.306 |
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| 2015 |
Heffeter P, Karnthaler-Benbakka C, Groza D, Kryeziu K, Berger W, Keppler BK, Kowol CR. Abstract 4397: Preclinical development of a novel hypoxia-activated EGFR inhibitor using a cobalt(III)-based prodrug design Cancer Research. 75: 4397-4397. DOI: 10.1158/1538-7445.Am2015-4397 |
0.335 |
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| 2015 |
Alte B, Pirker C, Mohr T, Kryeziu K, Keppler BK, Heffeter P, Berger W. Abstract 2573: Investigation of factors involved in the hypersensitivity to KP1339-treatment Cancer Research. 75: 2573-2573. DOI: 10.1158/1538-7445.Am2015-2573 |
0.337 |
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| 2015 |
Enyedy ÉA, Dömötör O, Hackl CM, Roller A, Novak MS, Jakupec MA, Keppler BK, Kandioller W. Solution equilibria and antitumor activities of pentamethylcyclopentadienyl rhodium complexes of picolinic acid and deferiprone Journal of Coordination Chemistry. DOI: 10.1080/00958972.2015.1023195 |
0.408 |
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| 2015 |
Mokesch S, Novak MS, Roller A, Jakupec MA, Kandioller W, Keppler BK. 1,3-dioxoindan-2-carboxamides as bioactive ligand scaffolds for the development of novel organometallic anticancer drugs Organometallics. 34: 848-857. DOI: 10.1021/Om501032S |
0.452 |
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| 2015 |
Legin A, Theiner S, Schintlmeister A, Reipert S, Heffeter P, Jakupec M, Kowol C, Galanski M, Berger W, Wagner M, Keppler B. 702 Multiscale distribution of anticancer platinum(IV) complexes in murine samples revealed by combination of NanoSIMS, LA-ICP-MS and TEM imaging European Journal of Cancer. 51. DOI: 10.1016/S0959-8049(16)30372-0 |
0.307 |
|
| 2015 |
Novak M, Hackl C, Kandioller W, Jakupec M, Keppler B. 356 Targeting DNA topoisomerase IIa activity with thiomaltol-based organometallic complexes European Journal of Cancer. 51. DOI: 10.1016/S0959-8049(16)30219-2 |
0.325 |
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| 2015 |
Kandioller W, Kubanik M, Bytzek AK, Jakupec MA, Roller A, Keppler BK, Hartinger CG. The rearrangement of tosylated flavones to 1′-(alkylamino)aurones with primary amines Tetrahedron. 71: 8953-8959. DOI: 10.1016/J.Tet.2015.09.062 |
0.321 |
|
| 2015 |
Schmidlehner M, Pichler V, Roller A, Jakupec MA, Kandioller W, Keppler BK. Organometallic complexes of (thio)allomaltol-based Mannich-products: Synthesis, stability and preliminary biological investigations Journal of Organometallic Chemistry. 782: 69-76. DOI: 10.1016/J.Jorganchem.2014.10.044 |
0.439 |
|
| 2015 |
Hoffmeister BR, Hejl M, Jakupec MA, Galanski M, Keppler BK. Bis- and Tris(carboxylato)platinum(IV) Complexes with Mixed Am(m)ine Ligands in the trans Position Exhibiting Exceptionally High Cytotoxicity European Journal of Inorganic Chemistry. 2015: 1700-1708. DOI: 10.1002/Ejic.201403226 |
0.393 |
|
| 2014 |
Martinčič A, Milačič R, Vidmar J, Turel I, Keppler BK, Sčančar J. New method for the speciation of ruthenium-based chemotherapeutics in human serum by conjoint liquid chromatography on affinity and anion-exchange monolithic disks. Journal of Chromatography. A. 1371: 168-76. PMID 25456595 DOI: 10.1016/J.Chroma.2014.10.054 |
0.377 |
|
| 2014 |
Jungwirth U, Gojo J, Tuder T, Walko G, Holcmann M, Schöfl T, Nowikovsky K, Wilfinger N, Schoonhoven S, Kowol CR, Lemmens-Gruber R, Heffeter P, Keppler BK, Berger W. Calpain-mediated integrin deregulation as a novel mode of action for the anticancer gallium compound KP46. Molecular Cancer Therapeutics. 13: 2436-49. PMID 25082959 DOI: 10.1158/1535-7163.Mct-14-0087 |
0.343 |
|
| 2014 |
Varbanov HP, Göschl S, Heffeter P, Theiner S, Roller A, Jensen F, Jakupec MA, Berger W, Galanski M, Keppler BK. A novel class of bis- and tris-chelate diam(m)inebis(dicarboxylato)platinum(IV) complexes as potential anticancer prodrugs. Journal of Medicinal Chemistry. 57: 6751-64. PMID 25032896 DOI: 10.1021/Jm500791C |
0.452 |
|
| 2014 |
Hudej R, Miklavcic D, Cemazar M, Todorovic V, Sersa G, Bergamo A, Sava G, Martincic A, Scancar J, Keppler BK, Turel I. Modulation of activity of known cytotoxic ruthenium(III) compound (KP418) with hampered transmembrane transport in electrochemotherapy in vitro and in vivo. The Journal of Membrane Biology. 247: 1239-51. PMID 24957014 DOI: 10.1007/S00232-014-9696-2 |
0.372 |
|
| 2014 |
Hanif M, Nawaz MA, Babak MV, Iqbal J, Roller A, Keppler BK, Hartinger CG. RutheniumII(η6-arene) complexes of thiourea derivatives: synthesis, characterization and urease inhibition. Molecules (Basel, Switzerland). 19: 8080-92. PMID 24936709 DOI: 10.3390/Molecules19068080 |
0.443 |
|
| 2014 |
Meier SM, Novak MS, Kandioller W, Jakupec MA, Roller A, Keppler BK, Hartinger CG. Aqueous chemistry and antiproliferative activity of a pyrone-based phosphoramidate Ru(arene) anticancer agent. Dalton Transactions (Cambridge, England : 2003). 43: 9851-5. PMID 24872129 DOI: 10.1039/C4Dt00569D |
0.356 |
|
| 2014 |
Egger AE, Theiner S, Kornauth C, Heffeter P, Berger W, Keppler BK, Hartinger CG. Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice. Metallomics : Integrated Biometal Science. 6: 1616-25. PMID 24823867 DOI: 10.1039/C4Mt00072B |
0.301 |
|
| 2014 |
Ossipov K, Scaffidi-Domianello YY, Seregina IF, Galanski M, Keppler BK, Timerbaev AR, Bolshov MA. Inductively coupled plasma mass spectrometry for metallodrug development: albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes. Journal of Inorganic Biochemistry. 137: 40-45. PMID 24803025 DOI: 10.1016/J.Jinorgbio.2014.04.008 |
0.389 |
|
| 2014 |
Meier SM, Babak MV, Keppler BK, Hartinger CG. Efficiently detecting metallodrug-protein adducts: ion trap versus time-of-flight mass analyzers. Chemmedchem. 9: 1351-5. PMID 24643974 DOI: 10.1002/Cmdc.201400020 |
0.319 |
|
| 2014 |
Dömötör O, Aicher S, Schmidlehner M, Novak MS, Roller A, Jakupec MA, Kandioller W, Hartinger CG, Keppler BK, Enyedy ÉA. Antitumor pentamethylcyclopentadienyl rhodium complexes of maltol and allomaltol: synthesis, solution speciation and bioactivity. Journal of Inorganic Biochemistry. 134: 57-65. PMID 24556426 DOI: 10.1016/J.Jinorgbio.2014.01.020 |
0.429 |
|
| 2014 |
Legin AA, Jakupec MA, Bokach NA, Tyan MR, Kukushkin VY, Keppler BK. Guanidine platinum(II) complexes: synthesis, in vitro antitumor activity, and DNA interactions. Journal of Inorganic Biochemistry. 133: 33-9. PMID 24444821 DOI: 10.1016/J.Jinorgbio.2013.12.007 |
0.396 |
|
| 2014 |
Fischer B, Heffeter P, Kryeziu K, Gille L, Meier SM, Berger W, Kowol CR, Keppler BK. Poly(lactic acid) nanoparticles of the lead anticancer ruthenium compound KP1019 and its surfactant-mediated activation. Dalton Transactions (Cambridge, England : 2003). 43: 1096-104. PMID 24165902 DOI: 10.1039/C3Dt52388H |
0.345 |
|
| 2014 |
Legin AA, Schintlmeister A, Jakupec MA, Galanski M, Lichtscheidl I, Wagner M, Keppler BK. NanoSIMS combined with fluorescence microscopy as a tool for subcellular imaging of isotopically labeled platinum-based anticancer drugs Chemical Science. 5: 3135-3143. DOI: 10.1039/C3Sc53426J |
0.315 |
|
| 2014 |
Trondl R, Heffeter P, Kowol CR, Jakupec MA, Berger W, Keppler BK. NKP-1339, the first ruthenium-based anticancer drug on the edge to clinical application Chemical Science. 5: 2925-2932. DOI: 10.1039/C3Sc53243G |
0.377 |
|
| 2014 |
Brynzak E, Heffeter P, Pichler V, Jakupec M, Keppler B. 156 Behaviour of platinum(IV) complexes with prodrug function in different models of hypoxia European Journal of Cancer. 50: 53. DOI: 10.1016/S0959-8049(14)70282-5 |
0.305 |
|
| 2014 |
Göschl S, Pichler V, Brynzak E, Heffeter P, Jungwirth U, Jakupec M, Berger W, Galanski M, Keppler B. 52 Platinum(IV) derivatives of oxaliplatin: Cellular effects and in vivo potency European Journal of Cancer. 50: 22. DOI: 10.1016/S0959-8049(14)70178-9 |
0.344 |
|
| 2014 |
Tamasi G, Carpini A, Valensin D, Messori L, Pratesi A, Scaletti F, Jakupec M, Keppler B, Cini R. {Ru(CO)x}-core complexes with selected azoles: Synthesis, X-ray structure, spectroscopy, DFT analysis and evaluation of cytotoxic activity against human cancer cells Polyhedron. 81: 227-237. DOI: 10.1016/J.Poly.2014.05.067 |
0.402 |
|
| 2014 |
Sija E, Hartinger CG, Keppler BK, Kiss T, Enyedy EA. Solution equilibrium studies of anticancer ruthenium(II)-η6- p-cymene complexes of pyridinecarboxylic acids Polyhedron. 67: 51-58. DOI: 10.1016/J.Poly.2013.08.057 |
0.37 |
|
| 2014 |
Schmidlehner M, Kuhn PS, Hackl CM, Roller A, Kandioller W, Keppler BK. Microwave-assisted synthesis of N-heterocycle-based organometallics Journal of Organometallic Chemistry. 772: 93-99. DOI: 10.1016/J.Jorganchem.2014.08.013 |
0.367 |
|
| 2014 |
Banfić J, Legin AA, Jakupec MA, Galanski M, Keppler BK. Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands – Synthesis, Characterization, and Cytotoxicity European Journal of Inorganic Chemistry. 2014: 484-492. DOI: 10.1002/Ejic.201301282 |
0.425 |
|
| 2013 |
Hanif M, Meier SM, Nazarov AA, Risse J, Legin A, Casini A, Jakupec MA, Keppler BK, Hartinger CG. Influence of the π-coordinated arene on the anticancer activity of ruthenium(II) carbohydrate organometallic complexes. Frontiers in Chemistry. 1: 27. PMID 24790955 DOI: 10.3389/Fchem.2013.00027 |
0.45 |
|
| 2013 |
Heffeter P, Atil B, Kryeziu K, Groza D, Koellensperger G, Körner W, Jungwirth U, Mohr T, Keppler BK, Berger W. The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo. European Journal of Cancer (Oxford, England : 1990). 49: 3366-75. PMID 23790465 DOI: 10.1016/J.Ejca.2013.05.018 |
0.352 |
|
| 2013 |
Pichler V, Göschl S, Meier SM, Roller A, Jakupec MA, Galanski M, Keppler BK. Bulky N(,N)-(di)alkylethane-1,2-diamineplatinum(II) compounds as precursors for generating unsymmetrically substituted platinum(IV) complexes. Inorganic Chemistry. 52: 8151-62. PMID 23790208 DOI: 10.1021/Ic400816G |
0.416 |
|
| 2013 |
Enyedy EA, Sija E, Jakusch T, Hartinger CG, Kandioller W, Keppler BK, Kiss T. Solution equilibria of anticancer ruthenium(II)-(η(6)-p-cymene)-hydroxy(thio)pyr(id)one complexes: impact of sulfur vs. oxygen donor systems on the speciation and bioactivity. Journal of Inorganic Biochemistry. 127: 161-8. PMID 23721887 DOI: 10.1016/J.Jinorgbio.2013.05.002 |
0.438 |
|
| 2013 |
Meier SM, Novak M, Kandioller W, Jakupec MA, Arion VB, Metzler-Nolte N, Keppler BK, Hartinger CG. Identification of the structural determinants for anticancer activity of a ruthenium arene peptide conjugate Chemistry - a European Journal. 19: 9297-9307. PMID 23712572 DOI: 10.1002/Chem.201300889 |
0.367 |
|
| 2013 |
Grabmann G, Keppler BK, Hartinger CG. A systematic capillary electrophoresis study on the effect of the buffer composition on the reactivity of the anticancer drug cisplatin to the DNA model 2'-deoxyguanosine 5'-monophosphate (dGMP). Analytical and Bioanalytical Chemistry. 405: 6417-24. PMID 23620371 DOI: 10.1007/S00216-013-6937-7 |
0.365 |
|
| 2013 |
Kupcewicz B, Sobiesiak K, Malinowska K, Koprowska K, Czyz M, Keppler B, Budzisz E. Copper(II) complexes with derivatives of pyrazole as potential antioxidant enzyme mimics. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 22: 2395-2402. PMID 23542890 DOI: 10.1007/S00044-012-0233-5 |
0.363 |
|
| 2013 |
Kandioller W, Balsano E, Meier SM, Jungwirth U, Göschl S, Roller A, Jakupec MA, Berger W, Keppler BK, Hartinger CG. Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity. Chemical Communications (Cambridge, England). 49: 3348-50. PMID 23505633 DOI: 10.1039/C3Cc40432C |
0.411 |
|
| 2013 |
Filak LK, Göschl S, Heffeter P, Samper KG, Egger AE, Jakupec MA, Keppler BK, Berger W, Arion VB. Metal-Arene Complexes with Indolo[3,2-c]-quinolines: Effects of Ruthenium vs Osmium and Modifications of the Lactam Unit on Intermolecular Interactions, Anticancer Activity, Cell Cycle, and Cellular Accumulation. Organometallics. 32: 903-914. PMID 23431223 DOI: 10.1021/Om3012272 |
0.449 |
|
| 2013 |
Pichler V, Mayr J, Heffeter P, Dömötör O, Enyedy ÉA, Hermann G, Groza D, Köllensperger G, Galanksi M, Berger W, Keppler BK, Kowol CR. Maleimide-functionalised platinum(IV) complexes as a synthetic platform for targeted drug delivery. Chemical Communications (Cambridge, England). 49: 2249-2251. PMID 23396381 DOI: 10.1039/C3Cc39258A |
0.367 |
|
| 2013 |
Valiahdi SM, Egger AE, Miklos W, Jungwirth U, Meelich K, Nock P, Berger W, Hartinger CG, Galanski M, Jakupec MA, Keppler BK. Influence of extracellular pH on the cytotoxicity, cellular accumulation, and DNA interaction of novel pH-sensitive 2-aminoalcoholatoplatinum(II) complexes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 18: 249-60. PMID 23354303 DOI: 10.1007/S00775-012-0970-4 |
0.37 |
|
| 2013 |
Babak MV, Meier SM, Legin AA, Adib Razavi MS, Roller A, Jakupec MA, Keppler BK, Hartinger CG. Am(m)ines make the difference: organoruthenium am(m)ine complexes and their chemistry in anticancer drug development. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 4308-18. PMID 23341078 DOI: 10.1002/Chem.201202657 |
0.47 |
|
| 2013 |
Hummer AA, Heffeter P, Berger W, Filipits M, Batchelor D, Büchel GE, Jakupec MA, Keppler BK, Rompel A. X-ray absorption near edge structure spectroscopy to resolve the in vivo chemistry of the redox-active indazolium trans-[Tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019). Journal of Medicinal Chemistry. 56: 1182-96. PMID 23282017 DOI: 10.1021/Jm301648F |
0.358 |
|
| 2013 |
Varbanov HP, Jakupec MA, Roller A, Jensen F, Galanski M, Keppler BK. Theoretical investigations and density functional theory based quantitative structure-activity relationships model for novel cytotoxic platinum(IV) complexes. Journal of Medicinal Chemistry. 56: 330-44. PMID 23214999 DOI: 10.1021/Jm3016427 |
0.401 |
|
| 2013 |
Kurzwernhart A, Kandioller W, Enyedy ÉA, Novak M, Jakupec MA, Keppler BK, Hartinger CG. 3-Hydroxyflavones vs. 3-hydroxyquinolinones: structure-activity relationships and stability studies on Ru(II)(arene) anticancer complexes with biologically active ligands. Dalton Transactions (Cambridge, England : 2003). 42: 6193-202. PMID 23168616 DOI: 10.1039/C2Dt32206D |
0.465 |
|
| 2013 |
Dömötör O, Hartinger CG, Bytzek AK, Kiss T, Keppler BK, Enyedy EA. Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 18: 9-17. PMID 23076343 DOI: 10.1007/S00775-012-0944-6 |
0.346 |
|
| 2013 |
Meier SM, Hanif M, Adhireksan Z, Pichler V, Novak M, Jirkovsky E, Jakupec MA, Arion VB, Davey CA, Keppler BK, Hartinger CG. Novel metal(ii) arene 2-pyridinecarbothioamides: a rationale to orally active organometallic anticancer agents Chemical Science. 4: 1837. DOI: 10.1039/C3Sc22294B |
0.449 |
|
| 2013 |
Ivanović I, Gligorijević N, Aranđelović S, Radulović S, Roller A, Keppler BK, Tešić ŽL, Grgurić-Šipka S. New ruthenium(II)-arene complexes bearing hydrazides and the corresponding (thio)semicarbazones of 3- and 4-acetylpyridine: Synthesis, characterization, crystal structure determination and antiproliferative activity Polyhedron. 61: 112-118. DOI: 10.1016/J.Poly.2013.05.050 |
0.452 |
|
| 2013 |
Schwarz MB, Kurzwernhart A, Roller A, Kandioller W, Keppler BK, Hartinger CG. Rhodium(Cp*) Compounds with Flavone‐derived Ligand Systems: Synthesis and Characterization Zeitschrift FüR Anorganische Und Allgemeine Chemie. 639: 1648-1654. DOI: 10.1002/Zaac.201300145 |
0.444 |
|
| 2013 |
Banfic J, Adib-Razavi MS, Galanski M, Keppler BK. Platinum(IV) Complexes Featuring Axial (1, 4–13C2)Succinato Ligands – Synthesis, Characterization, and Preliminary Investigations in Cancer Cell Lysates Zeitschrift FüR Anorganische Und Allgemeine Chemie. 639: 1613-1620. DOI: 10.1002/Zaac.201300058 |
0.441 |
|
| 2012 |
Pichler V, Heffeter P, Valiahdi SM, Kowol CR, Egger A, Berger W, Jakupec MA, Galanski M, Keppler BK. Unsymmetric mono- and dinuclear platinum(IV) complexes featuring an ethylene glycol moiety: synthesis, characterization, and biological activity. Journal of Medicinal Chemistry. 55: 11052-61. PMID 23194425 DOI: 10.1021/Jm301645G |
0.407 |
|
| 2012 |
Kurzwernhart A, Kandioller W, Bächler S, Bartel C, Martic S, Buczkowska M, Mühlgassner G, Jakupec MA, Kraatz HB, Bednarski PJ, Arion VB, Marko D, Keppler BK, Hartinger CG. Structure-activity relationships of targeted RuII(η6-p-cymene) anticancer complexes with flavonol-derived ligands. Journal of Medicinal Chemistry. 55: 10512-22. PMID 23134291 DOI: 10.1021/Jm301376A |
0.453 |
|
| 2012 |
Enyedy ÉA, Dömötör O, Varga E, Kiss T, Trondl R, Hartinger CG, Keppler BK. Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands. Journal of Inorganic Biochemistry. 117: 189-97. PMID 23089600 DOI: 10.1016/J.Jinorgbio.2012.08.005 |
0.395 |
|
| 2012 |
Ginzinger W, Egger A, Mühlgassner G, Arion VB, Jakupec MA, Galanski M, Berger W, Keppler BK. Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis. Chemistry & Biodiversity. 9: 2175-2185. PMID 23081917 DOI: 10.1002/Cbdv.201200147 |
0.362 |
|
| 2012 |
Mühlgassner G, Bartel C, Schmid WF, Jakupec MA, Arion VB, Keppler BK. Biological activity of ruthenium and osmium arene complexes with modified paullones in human cancer cells. Journal of Inorganic Biochemistry. 116: 180-7. PMID 23037896 DOI: 10.1016/J.Jinorgbio.2012.06.003 |
0.408 |
|
| 2012 |
Hoffmeister BR, Adib-Razavi MS, Jakupec MA, Galanski M, Keppler BK. Diamminetetrakis(carboxylato)platinum(IV) complexes--synthesis, characterization, and cytotoxicity. Chemistry & Biodiversity. 9: 1840-1848. PMID 22976974 DOI: 10.1002/Cbdv.201200019 |
0.408 |
|
| 2012 |
Henke H, Kandioller W, Hanif M, Keppler BK, Hartinger CG. Organometallic ruthenium and osmium compounds of pyridin-2- and -4-ones as potential anticancer agents. Chemistry & Biodiversity. 9: 1718-27. PMID 22976964 DOI: 10.1002/Cbdv.201200005 |
0.426 |
|
| 2012 |
Grabmann G, Meier SM, Scaffidi-Domianello YY, Galanski M, Keppler BK, Hartinger CG. Capillary zone electrophoresis and capillary zone electrophoresis-electrospray ionization mass spectrometry studies on the behavior of anticancer cis- and trans-[dihalidobis(2-propanone oxime)platinum(II)] complexes in aqueous solutions. Journal of Chromatography. A. 1267: 156-61. PMID 22897861 DOI: 10.1016/J.Chroma.2012.07.062 |
0.4 |
|
| 2012 |
Milunovic MN, Enyedy É, Nagy NV, Kiss T, Trondl R, Jakupec MA, Keppler BK, Krachler R, Novitchi G, Arion VB. L- and D-proline thiosemicarbazone conjugates: coordination behavior in solution and the effect of copper(II) coordination on their antiproliferative activity. Inorganic Chemistry. 51: 9309-21. PMID 22889304 DOI: 10.1021/Ic300967J |
0.391 |
|
| 2012 |
Varbanov HP, Valiahdi SM, Kowol CR, Jakupec MA, Galanski M, Keppler BK. Novel tetracarboxylatoplatinum(IV) complexes as carboplatin prodrugs Dalton Transactions. 41: 14404-14415. PMID 22886297 DOI: 10.1039/C2Dt31366A |
0.476 |
|
| 2012 |
Arion VB, Dobrov A, Göschl S, Jakupec MA, Keppler BK, Rapta P. Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs. Chemical Communications. 48: 8559-8561. PMID 22797078 DOI: 10.1039/C2Cc33786J |
0.403 |
|
| 2012 |
Scaffidi-Domianello YY, Legin AA, Jakupec MA, Roller A, Kukushkin VY, Galanski M, Keppler BK. Novel oximato-bridged platinum(II) di- and trimer(s): synthetic, structural, and in vitro anticancer activity studies. Inorganic Chemistry. 51: 7153-63. PMID 22691006 DOI: 10.1021/Ic300148E |
0.358 |
|
| 2012 |
Büchel GE, Stepanenko IN, Hejl M, Jakupec MA, Keppler BK, Heffeter P, Berger W, Arion VB. Osmium(IV) complexes with 1H- and 2H-indazoles: tautomer identity versus spectroscopic properties and antiproliferative activity. Journal of Inorganic Biochemistry. 113: 47-54. PMID 22687494 DOI: 10.1016/J.Jinorgbio.2012.04.001 |
0.355 |
|
| 2012 |
Hummer AA, Bartel C, Arion VB, Jakupec MA, Meyer-Klaucke W, Geraki T, Quinn PD, Mijovilovich A, Keppler BK, Rompel A. X-ray absorption spectroscopy of an investigational anticancer gallium(III) drug: interaction with serum proteins, elemental distribution pattern, and coordination of the compound in tissue. Journal of Medicinal Chemistry. 55: 5601-13. PMID 22621452 DOI: 10.1021/Jm3005459 |
0.343 |
|
| 2012 |
Kurzwernhart A, Kandioller W, Bartel C, Bächler S, Trondl R, Mühlgassner G, Jakupec MA, Arion VB, Marko D, Keppler BK, Hartinger CG. Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder. Chemical Communications (Cambridge, England). 48: 4839-41. PMID 22498692 DOI: 10.1039/C2Cc31040F |
0.346 |
|
| 2012 |
Buß I, Kalayda GV, Lindauer A, Reithofer MR, Galanski M, Keppler BK, Jaehde U. Effect of reactivity on cellular accumulation and cytotoxicity of oxaliplatin analogues. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 699-708. PMID 22456982 DOI: 10.1007/S00775-012-0889-9 |
0.377 |
|
| 2012 |
Heffeter P, Pirker C, Kowol CR, Herrman G, Dornetshuber R, Miklos W, Jungwirth U, Koellensperger G, Keppler BK, Berger W. Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones Biochemical Pharmacology. 83: 1623-1633. PMID 22426010 DOI: 10.1016/J.Bcp.2012.03.004 |
0.335 |
|
| 2012 |
Meier SM, Hanif M, Kandioller W, Keppler BK, Hartinger CG. Biomolecule binding vs. anticancer activity: reactions of Ru(arene)[(thio)pyr-(id)one] compounds with amino acids and proteins. Journal of Inorganic Biochemistry. 108: 91-5. PMID 22420927 DOI: 10.1016/J.Jinorgbio.2011.08.011 |
0.422 |
|
| 2012 |
Ginzinger W, Mühlgassner G, Arion VB, Jakupec MA, Roller A, Galanski M, Reithofer M, Berger W, Keppler BK. A SAR Study of Novel Antiproliferative Ruthenium and Osmium Complexes with Quinoxalinone Ligands in Human Cancer Cell Lines Journal of Medicinal Chemistry. 55: 3398-3413. PMID 22417128 DOI: 10.1021/Jm3000906 |
0.475 |
|
| 2012 |
Jungwirth U, Xanthos DN, Gojo J, Bytzek AK, Körner W, Heffeter P, Abramkin SA, Jakupec MA, Hartinger CG, Windberger U, Galanski M, Keppler BK, Berger W. Anticancer activity of methyl-substituted oxaliplatin analogs. Molecular Pharmacology. 81: 719-28. PMID 22331606 DOI: 10.1124/Mol.111.077321 |
0.339 |
|
| 2012 |
Abramkin S, Valiahdi SM, Jakupec MA, Galanski M, Metzler-Nolte N, Keppler BK. Solid-phase synthesis of oxaliplatin-TAT peptide bioconjugates Dalton Transactions. 41: 3001-3005. PMID 22281694 DOI: 10.1039/C2Dt12024K |
0.325 |
|
| 2012 |
Bartel C, Bytzek AK, Scaffidi-Domianello YY, Grabmann G, Jakupec MA, Hartinger CG, Galanski M, Keppler BK. Cellular accumulation and DNA interaction studies of cytotoxic trans-platinum anticancer compounds. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 17: 465-74. PMID 22227950 DOI: 10.1007/S00775-011-0869-5 |
0.415 |
|
| 2012 |
Kowol CR, Heffeter P, Miklos W, Gille L, Trondl R, Cappellacci L, Berger W, Keppler BK. Mechanisms underlying reductant-induced reactive oxygen species formation by anticancer copper(II) compounds. Journal of Biological Inorganic Chemistry. 17: 409-423. PMID 22189939 DOI: 10.1007/S00775-011-0864-X |
0.377 |
|
| 2012 |
Hanif M, Nazarov AA, Legin A, Groessl M, Arion VB, Jakupec MA, Tsybin YO, Dyson PJ, Keppler BK, Hartinger CG. Maleimide-functionalised organoruthenium anticancer agents and their binding to thiol-containing biomolecules. Chemical Communications (Cambridge, England). 48: 1475-7. PMID 22003496 DOI: 10.1039/C1Cc14713G |
0.365 |
|
| 2012 |
Trondl R, Heffeter P, Jakupec MA, Berger W, Keppler BK. NKP-1339, a first-in-class anticancer drug showing mild side effects and activity in patients suffering from advanced refractory cancer Bmc Clinical Pharmacology. 13: 1-1. DOI: 10.1186/2050-6511-13-S1-A82 |
0.352 |
|
| 2012 |
Hudej R, Kljun J, Kandioller W, Repnik U, Turk B, Hartinger CG, Keppler BK, Miklavčič D, Turel I. Synthesis and Biological Evaluation of the Thionated Antibacterial Agent Nalidixic Acid and Its Organoruthenium(II) Complex Organometallics. 31: 5867-5874. DOI: 10.1021/Om300424W |
0.435 |
|
| 2012 |
Gavrish SP, Lampeka YD, Lightfoot P, Arion VB, Keppler BK, Woźniak K. Solid State Structural Variations in Copper(II) Complexes of Open-Chain and Macrocyclic Malonamide-Derived Ligands Crystal Growth & Design. 12: 4388-4396. DOI: 10.1021/Cg300554R |
0.401 |
|
| 2012 |
Novak M, Büchel G, Gavriluta A, Tommasino J, Luneau D, Jakupec M, Arion V, Keppler B. 523 Biological Effects of Ruthenium and Osmium Nitrosyl Complexes with Azole Heterocycles European Journal of Cancer. 48: 161. DOI: 10.1016/S0959-8049(12)72320-1 |
0.382 |
|
| 2012 |
Göschl S, Filak LK, Egger A, Jakupec MA, Keppler BK, Arion VB. 271 In Vitro Studies of Novel Ruthenium(II) and Osmium(II) Indoloquinoline Complexes European Journal of Cancer. 48: 83-84. DOI: 10.1016/S0959-8049(12)72069-5 |
0.371 |
|
| 2012 |
Enyedy EA, Zsigõ E, Nagy NV, Kowol CR, Roller A, Keppler BK, Kiss T. Complex-formation ability of salicylaldehyde thiosemicarbazone towards Zn II, Cu II, Fe II, Fe III and Ga III ions European Journal of Inorganic Chemistry. 4036-4047. DOI: 10.1002/Ejic.201200360 |
0.428 |
|
| 2011 |
Stepanenko IN, Casini A, Edafe F, Novak MS, Arion VB, Dyson PJ, Jakupec MA, Keppler BK. Conjugation of organoruthenium(II) 3-(1H-benzimidazol-2-yl)pyrazolo[3,4-b]pyridines and indolo[3,2-d]benzazepines to recombinant human serum albumin: a strategy to enhance cytotoxicity in cancer cells. Inorganic Chemistry. 50: 12669-79. PMID 22111668 DOI: 10.1021/Ic201801E |
0.388 |
|
| 2011 |
Scaffidi-Domianello YY, Legin AA, Jakupec MA, Arion VB, Kukushkin VY, Galanski M, Keppler BK. Synthesis, characterization, and cytotoxic activity of novel potentially pH-sensitive nonclassical platinum(II) complexes featuring 1,3-dihydroxyacetone oxime ligands. Inorganic Chemistry. 50: 10673-81. PMID 21951170 DOI: 10.1021/Ic2010612 |
0.411 |
|
| 2011 |
Varbanov H, Valiahdi SM, Legin AA, Jakupec MA, Roller A, Galanski M, Keppler BK. Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin European Journal of Medicinal Chemistry. 46: 5456-5464. PMID 21940073 DOI: 10.1016/J.Ejmech.2011.09.006 |
0.454 |
|
| 2011 |
Bytzek AK, Boeck K, Hermann G, Hann S, Keppler BK, Hartinger CG, Koellensperger G. LC- and CZE-ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma. Metallomics : Integrated Biometal Science. 3: 1049-55. PMID 21935553 DOI: 10.1039/C1Mt00055A |
0.33 |
|
| 2011 |
Pichler V, Valiahdi SM, Jakupec MA, Arion VB, Galanski M, Keppler BK. Mono-carboxylated diaminedichloridoplatinum(IV) complexes--selective synthesis, characterization, and cytotoxicity. Dalton Transactions (Cambridge, England : 2003). 40: 8187-92. PMID 21743934 DOI: 10.1039/C1Dt10301F |
0.439 |
|
| 2011 |
Büchel GE, Stepanenko IN, Hejl M, Jakupec MA, Keppler BK, Arion VB. En route to osmium analogues of KP1019: synthesis, structure, spectroscopic properties and antiproliferative activity of trans-[Os(IV)Cl4(Hazole)2]. Inorganic Chemistry. 50: 7690-7. PMID 21739939 DOI: 10.1021/Ic200728B |
0.417 |
|
| 2011 |
Bartel C, Egger AE, Jakupec MA, Heffeter P, Galanski M, Berger W, Keppler BK. Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019. Journal of Biological Inorganic Chemistry. 16: 1205-1215. PMID 21706338 DOI: 10.1007/S00775-011-0809-4 |
0.382 |
|
| 2011 |
Enyedy EA, Horváth L, Hetényi A, Tuccinardi T, Hartinger CG, Keppler BK, Kiss T. Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: a combined spectroscopic and separation approach with molecular modeling studies. Bioorganic & Medicinal Chemistry. 19: 4202-10. PMID 21696966 DOI: 10.1016/J.Bmc.2011.05.063 |
0.356 |
|
| 2011 |
Kljun J, Bytzek AK, Kandioller W, Bartel C, Jakupec MA, Hartinger CG, Keppler BK, Turel I. Physicochemical Studies and Anticancer Potency of Ruthenium η-p-Cymene Complexes Containing Antibacterial Quinolones. Organometallics. 30: 2506-2512. PMID 21552495 DOI: 10.1021/Om101180C |
0.428 |
|
| 2011 |
Enyedy ÉA, Primik MF, Kowol CR, Arion VB, Kiss T, Keppler BK. Interaction of Triapine and related thiosemicarbazones with iron(III)/(II) and gallium(III): a comparative solution equilibrium study. Dalton Transactions (Cambridge, England : 2003). 40: 5895-905. PMID 21523301 DOI: 10.1039/C0Dt01835J |
0.398 |
|
| 2011 |
Buss I, Garmann D, Galanski M, Weber G, Kalayda GV, Keppler BK, Jaehde U. Enhancing lipophilicity as a strategy to overcome resistance against platinum complexes? Journal of Inorganic Biochemistry. 105: 709-17. PMID 21450275 DOI: 10.1016/J.Jinorgbio.2011.02.005 |
0.348 |
|
| 2011 |
Foteeva LS, Trofimov DA, Kuznetsova OV, Kowol CR, Arion VB, Keppler BK, Timerbaev AR. A quantitative structure-activity approach for lipophilicity estimation of antitumor complexes of different metals using microemulsion electrokinetic chromatography Journal of Pharmaceutical and Biomedical Analysis. 55: 409-413. PMID 21382684 DOI: 10.1016/J.Jpba.2011.02.011 |
0.359 |
|
| 2011 |
Jungwirth U, Kowol CR, Keppler BK, Hartinger CG, Berger W, Heffeter P. Anticancer activity of metal complexes: involvement of redox processes. Antioxidants & Redox Signaling. 15: 1085-127. PMID 21275772 DOI: 10.1089/Ars.2010.3663 |
0.349 |
|
| 2011 |
Filak LK, Mühlgassner G, Bacher F, Roller A, Galanski M, Jakupec MA, Keppler BK, Arion VB. Ruthenium- and Osmium-Arene Complexes of 2-Substituted Indolo[3,2-c]quinolines: Synthesis, Structure, Spectroscopic Properties, and Antiproliferative Activity. Organometallics. 30: 273-283. PMID 21253447 DOI: 10.1021/Om101004Z |
0.373 |
|
| 2011 |
Hanif M, Meier SM, Kandioller W, Bytzek A, Hejl M, Hartinger CG, Nazarov AA, Arion VB, Jakupec MA, Dyson PJ, Keppler BK. From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands. Journal of Inorganic Biochemistry. 105: 224-31. PMID 21194622 DOI: 10.1016/J.Jinorgbio.2010.10.004 |
0.462 |
|
| 2011 |
Reithofer MR, Bytzek AK, Valiahdi SM, Kowol CR, Groessl M, Hartinger CG, Jakupec MA, Galanski M, Keppler BK. Tuning of lipophilicity and cytotoxic potency by structural variation of anticancer platinum(IV) complexes. Journal of Inorganic Biochemistry. 105: 46-51. PMID 21134601 DOI: 10.1016/J.Jinorgbio.2010.09.006 |
0.419 |
|
| 2011 |
Bippus P, Skocic M, Jakupec MA, Keppler BK, Mohr F. Synthesis, structures and in vitro cytotoxicity of some cationic cis-platinum(II) complexes containing chelating thiocarbamates. Journal of Inorganic Biochemistry. 105: 462-6. PMID 20864176 DOI: 10.1016/J.Jinorgbio.2010.08.010 |
0.372 |
|
| 2011 |
Pashkunova-Martic I, Kremser C, Galanski M, Schluga P, Arion V, Debbage P, Jaschke W, Keppler B. Lectin conjugates as biospecific contrast agents for MRI. Coupling of Lycopersicon esculentum agglutinin to linear water-soluble DTPA-loaded oligomers. Molecular Imaging and Biology. 13: 432-442. PMID 20574850 DOI: 10.1007/S11307-010-0358-1 |
0.331 |
|
| 2011 |
Kratz F, Keppler BK, Messori L, Smith C, Baker EN. Protein-binding Properties of two Antitumour Ru(III) Complexes to Human Apotransferrin and Apolactoferrin. Metal-Based Drugs. 1: 169-73. PMID 18476228 DOI: 10.1155/Mbd.1994.169 |
0.427 |
|
| 2011 |
Pieper T, Peti W, Keppler BK. Solvolysis of the Tumor-Inhibiting Ru(III)-Complex trans-Tetrachlorobis(Indazole)Ruthenate(III). Metal-Based Drugs. 7: 225-32. PMID 18475949 DOI: 10.1155/Mbd.2000.225 |
0.432 |
|
| 2011 |
Ivanovic I, Grguric-Sipka S, Gligorijevic N, Radulovic SS, Roller A, Tesic ZL, Keppler B. X-ray structure and cytotoxic activity of a picolinate ruthenium(II)-arene complex Journal of the Serbian Chemical Society. 76: 53-61. DOI: 10.2298/Jsc100517017I |
0.437 |
|
| 2011 |
Heffeter P, Atil B, Kryeziu K, Jungwirth U, Gal E, Keppler BK, Berger W. Abstract 3541: Combination of the ruthenium compound KP1339 with the tyrosine kinase inhibitor sorafenib: A promising approach for the treatment of human hepatoma Cancer Research. 71: 3541-3541. DOI: 10.1158/1538-7445.Am2011-3541 |
0.323 |
|
| 2011 |
Trondl R, Jungwirth U, Heffeter P, Kowol CR, Arion VB, Jakupec MA, Keppler BK. Abstract 2637: Terminal dimethyl substitution of Triapine leads to activation of CHOP and induction of apoptosis via ER stress in human colon cancer cells Cancer Research. 71: 2637-2637. DOI: 10.1158/1538-7445.Am2011-2637 |
0.321 |
|
| 2011 |
Kandioller W, Kurzwernhart A, Hanif M, Meier SM, Henke H, Keppler BK, Hartinger CG. Pyrone derivatives and metals: From natural products to metal-based drugs Journal of Organometallic Chemistry. 696: 999-1010. DOI: 10.1016/J.Jorganchem.2010.11.010 |
0.3 |
|
| 2011 |
Apfel U, Kowol CR, Kloss F, Görls H, Keppler BK, Weigand W. Hydroxy and ether functionalized dithiolanes: Models for the active site of the [FeFe] hydrogenase Journal of Organometallic Chemistry. 696: 1084-1088. DOI: 10.1016/J.Jorganchem.2010.09.048 |
0.315 |
|
| 2010 |
Primik MF, Göschl S, Jakupec MA, Roller A, Keppler BK, Arion VB. Structure−Activity Relationships of Highly Cytotoxic Copper(II) Complexes with Modified Indolo[3,2-c]quinoline Ligands Inorganic Chemistry. 49: 11084-11095. PMID 20979395 DOI: 10.1021/Ic101633Z |
0.345 |
|
| 2010 |
Abramkin SA, Jungwirth U, Valiahdi SM, Dworak C, Habala L, Meelich K, Berger W, Jakupec MA, Hartinger CG, Nazarov AA, Galanski M, Keppler BK. {(1R,2R,4R)-4-methyl-1,2-cyclohexanediamine}oxalatoplatinum(II): a novel enantiomerically pure oxaliplatin derivative showing improved anticancer activity in vivo. Journal of Medicinal Chemistry. 53: 7356-64. PMID 20886814 DOI: 10.1021/Jm100953C |
0.344 |
|
| 2010 |
Hanif M, Henke H, Meier SM, Martic S, Labib M, Kandioller W, Jakupec MA, Arion VB, Kraatz HB, Keppler BK, Hartinger CG. Is the reactivity of M(II)-arene complexes of 3-hydroxy-2(1H)-pyridones to biomolecules the anticancer activity determining parameter? Inorganic Chemistry. 49: 7953-63. PMID 20704358 DOI: 10.1021/Ic1009785 |
0.461 |
|
| 2010 |
Hanif M, Nazarov AA, Hartinger CG, Kandioller W, Jakupec MA, Arion VB, Dyson PJ, Keppler BK. Osmium(II)--versus ruthenium(II)--arene carbohydrate-based anticancer compounds: similarities and differences. Dalton Transactions (Cambridge, England : 2003). 39: 7345-52. PMID 20601976 DOI: 10.1039/C003085F |
0.437 |
|
| 2010 |
Scaffidi-Domianello YY, Meelich K, Jakupec MA, Arion VB, Kukushkin VY, Galanski M, Keppler BK. Novel cis- and trans-configured bis(oxime)platinum(II) complexes: synthesis, characterization, and cytotoxic activity. Inorganic Chemistry. 49: 5669-78. PMID 20459062 DOI: 10.1021/Ic100584B |
0.427 |
|
| 2010 |
Tamasi G, Casolaro M, Magnani A, Sega A, Chiasserini L, Messori L, Gabbiani C, Valiahdi SM, Jakupec MA, Keppler BK, Hursthouse MB, Cini R. New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro. Journal of Inorganic Biochemistry. 104: 799-814. PMID 20447694 DOI: 10.1016/J.Jinorgbio.2010.03.010 |
0.393 |
|
| 2010 |
Filak LK, Mühlgassner G, Jakupec MA, Heffeter P, Berger W, Arion VB, Keppler BK. Organometallic indolo[3,2-c]quinolines versus indolo[3,2-d]benzazepines: synthesis, structural and spectroscopic characterization, and biological efficacy. Journal of Biological Inorganic Chemistry. 15: 903-918. PMID 20369265 DOI: 10.1007/S00775-010-0653-Y |
0.368 |
|
| 2010 |
Djinovic VM, Galanski M, Arion VB, Keppler BK. Synthesis and structures of novel 1-methylcytosinato-bridged (ethylenediamine)platinum(II) and platinum(III) dinuclear complexes. Dalton Transactions. 39: 3633-3643. PMID 20354616 DOI: 10.1039/B926133H |
0.366 |
|
| 2010 |
Bytzek AK, Reithofer MR, Galanski M, Groessl M, Keppler BK, Hartinger CG. The first example of MEEKC-ICP-MS coupling and its application for the analysis of anticancer platinum complexes. Electrophoresis. 31: 1144-50. PMID 20349510 DOI: 10.1002/Elps.200900522 |
0.361 |
|
| 2010 |
Heffeter P, Böck K, Atil B, Reza Hoda MA, Körner W, Bartel C, Jungwirth U, Keppler BK, Micksche M, Berger W, Koellensperger G. Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 737-48. PMID 20221888 DOI: 10.1007/S00775-010-0642-1 |
0.358 |
|
| 2010 |
Groessl M, Tsybin YO, Hartinger CG, Keppler BK, Dyson PJ. Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 15: 677-88. PMID 20213306 DOI: 10.1007/S00775-010-0635-0 |
0.307 |
|
| 2010 |
Kowol CR, Trondl R, Arion VB, Jakupec MA, Lichtscheidl I, Keppler BK. Fluorescence properties and cellular distribution of the investigational anticancer drug triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) and its zinc(II) complex. Dalton Transactions. 39: 704-706. PMID 20066211 DOI: 10.1039/B919119B |
0.318 |
|
| 2010 |
Grgurić-Šipka S, Ivanović I, Rakić G, Todorović N, Gligorijević N, Radulović S, Arion VB, Keppler BK, Tešić ŽL. Ruthenium(II)–arene complexes with functionalized pyridines: Synthesis, characterization and cytotoxic activity European Journal of Medicinal Chemistry. 45: 1051-1058. PMID 20053483 DOI: 10.1016/J.Ejmech.2009.11.055 |
0.42 |
|
| 2010 |
Primik MF, Mühlgassner G, Jakupec MA, Zava O, Dyson PJ, Arion VB, Keppler BK. Highly cytotoxic copper(II) complexes with modified paullone ligands. Inorganic Chemistry. 49: 302-11. PMID 19968251 DOI: 10.1021/Ic902042A |
0.402 |
|
| 2010 |
Trondl R, Kowol CR, Arion VB, Jakupec MA, Keppler BK. α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation Bmc Pharmacology. 10: 1-1. DOI: 10.1186/1471-2210-10-S1-A20 |
0.335 |
|
| 2010 |
Hanif M, Schaaf P, Kandioller W, Hejl M, Jakupec MA, Roller A, Keppler BK, Hartinger CG. Influence of the Arene Ligand and the Leaving Group on the Anticancer Activity of (Thio)maltol Ruthenium(II)–(η6-Arene) Complexes Australian Journal of Chemistry. 63: 1521-1528. DOI: 10.1071/Ch10232 |
0.46 |
|
| 2010 |
Jungwirth U, Heffeter P, Gojo J, Abramkin S, Meelich K, Körner W, Micksche M, Galanski M, Keppler BK, Berger W. 447 Stereoisomerism significantly impacts on the anticancer activity of novel oxaliplatin analogues in vitro and in vivo Ejc Supplements. 8: 141. DOI: 10.1016/S1359-6349(10)72154-6 |
0.3 |
|
| 2010 |
Kasser JH, Kandioller W, Hartinger CG, Nazarov AA, Arion VB, Dyson PJ, Keppler BK. Mannich products of kojic acid and N-heterocycles and their Ru(II)-arene complexes: Synthesis, characterization and stability Journal of Organometallic Chemistry. 695: 875-881. DOI: 10.1016/J.Jorganchem.2010.01.007 |
0.439 |
|
| 2010 |
Apfel U, Kowol CR, Morera E, Görls H, Lucente G, Keppler BK, Weigand W. Synthetic and Electrochemical Studies of [2Fe2S] Complexes Containing a 4-Amino-1,2-dithiolane-4-carboxylic Acid Moiety European Journal of Inorganic Chemistry. 2010: 5079-5086. DOI: 10.1002/Ejic.201000619 |
0.362 |
|
| 2010 |
Enyedy ÉA, Nagy NV, Zsigó É, Kowol CR, Arion VB, Keppler BK, Kiss T. Comparative Solution Equilibrium Study of the Interactions of Copper(II), Iron(II) and Zinc(II) with Triapine (3‐Aminopyridine‐2‐carbaldehyde Thiosemicarbazone) and Related Ligands European Journal of Inorganic Chemistry. 2010: 1717-1728. DOI: 10.1002/Ejic.200901174 |
0.4 |
|
| 2009 |
Egger AE, Rappel C, Jakupec MA, Hartinger CG, Heffeter P, Keppler BK. Development of an experimental protocol for uptake studies of metal compounds in adherent tumor cells. Journal of Analytical Atomic Spectrometry. 24: 51-61. PMID 22723721 DOI: 10.1039/B810481F |
0.345 |
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| 2009 |
Schuh E, Valiahdi SM, Jakupec MA, Keppler BK, Chiba P, Mohr F. Synthesis and biological studies of some gold(I) complexes containing functionalised alkynes. Dalton Transactions (Cambridge, England : 2003). 10841-5. PMID 20023914 DOI: 10.1039/B911234K |
0.391 |
|
| 2009 |
Biba F, Groessl M, Egger A, Jakupec MA, Keppler BK. A Novel Cytotoxic Cerium Complex: Aquatrichloridobis(1,10-phenanthroline)cerium(III) (KP776). Synthesis, Characterization, Behavior in H2O, Binding towards Biomolecules, and Antiproliferative Activity Chemistry & Biodiversity. 6: 2153-2165. PMID 20020447 DOI: 10.1002/Cbdv.200900011 |
0.423 |
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| 2009 |
Bytzek AK, Enyedy EA, Kiss T, Keppler BK, Hartinger CG. Biodistribution of anti-diabetic Zn(II) complexes in human serum and in vitro protein-binding studies by means of CZE-ICP-MS. Electrophoresis. 30: 4075-82. PMID 19960475 DOI: 10.1002/Elps.200900212 |
0.362 |
|
| 2009 |
Büchel GE, Stepanenko IN, Hejl M, Jakupec MA, Arion VB, Keppler BK. [Os(IV)Cl(5)(Hazole)](-) complexes: synthesis, structure, spectroscopic properties, and antiproliferative activity. Inorganic Chemistry. 48: 10737-47. PMID 19842663 DOI: 10.1021/Ic901671J |
0.432 |
|
| 2009 |
Kandioller W, Hartinger CG, Nazarov AA, Bartel C, Skocic M, Jakupec MA, Arion VB, Keppler BK. Maltol-derived ruthenium-cymene complexes with tumor inhibiting properties: the impact of ligand-metal bond stability on anticancer activity in vitro. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 12283-91. PMID 19821465 DOI: 10.1002/Chem.200901939 |
0.471 |
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| 2009 |
Bergamo A, Masi A, Jakupec MA, Keppler BK, Sava G. Inhibitory Effects of the Ruthenium Complex KP1019 in Models of Mammary Cancer Cell Migration and Invasion Metal-Based Drugs. 2009: 681270-681270. PMID 19789639 DOI: 10.1155/2009/681270 |
0.347 |
|
| 2009 |
Apfel UP, Kowol CR, Halpin Y, Kloss F, Kübel J, Görls H, Vos JG, Keppler BK, Morera E, Lucente G, Weigand W. Investigation of amino acid containing [FeFe] hydrogenase models concerning pendant base effects. Journal of Inorganic Biochemistry. 103: 1236-44. PMID 19664823 DOI: 10.1016/J.Jinorgbio.2009.07.005 |
0.313 |
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| 2009 |
Kowol CR, Trondl R, Heffeter P, Arion VB, Jakupec MA, Roller A, Galanski M, Berger W, Keppler BK. Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation. Journal of Medicinal Chemistry. 52: 5032-5043. PMID 19637923 DOI: 10.1021/Jm900528D |
0.466 |
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| 2009 |
Valiahdi SM, Heffeter P, Jakupec MA, Marculescu R, Berger W, Rappersberger K, Keppler BK. The gallium complex KP46 exerts strong activity against primary explanted melanoma cells and induces apoptosis in melanoma cell lines Melanoma Research. 19: 283-293. PMID 19584767 DOI: 10.1097/Cmr.0B013E32832B272D |
0.34 |
|
| 2009 |
Heffeter P, Popovic-Bijelic A, Saiko P, Dornetshuber R, Jungwirth U, Voevodskaya N, Biglino D, Jakupec MA, Elbling L, Micksche M, Szekeres T, Keppler BK, Gräslund A, Berger W. Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772). Current Cancer Drug Targets. 9: 595-607. PMID 19508176 DOI: 10.2174/156800909789056962 |
0.328 |
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| 2009 |
Grguric-Sipka S, Stepanenko IN, Lazic JM, Bartel C, Jakupec MA, Arion VB, Keppler BK. Synthesis, X-ray diffraction structure, spectroscopic properties and antiproliferative activity of a novel ruthenium complex with constitutional similarity to cisplatin. Dalton Transactions. 3334-9. PMID 19421637 DOI: 10.1039/B822725J |
0.423 |
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| 2009 |
Mendoza-Ferri MG, Hartinger CG, Mendoza MA, Groessl M, Egger AE, Eichinger RE, Mangrum JB, Farrell NP, Maruszak M, Bednarski PJ, Klein F, Jakupec MA, Nazarov AA, Severin K, Keppler BK. Transferring the concept of multinuclearity to ruthenium complexes for improvement of anticancer activity. Journal of Medicinal Chemistry. 52: 916-25. PMID 19170599 DOI: 10.1021/Jm8013234 |
0.447 |
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| 2009 |
Nováková O, Nazarov AA, Hartinger CG, Keppler BK, Brabec V. DNA interactions of dinuclear RuII arene antitumor complexes in cell-free media Biochemical Pharmacology. 77: 364-374. PMID 19014908 DOI: 10.1016/J.Bcp.2008.10.021 |
0.405 |
|
| 2009 |
Jungwirth U, Heffeter P, Gojo J, Abramkin S, Meelich K, Galanski M, Körner W, Micksche MM, Keppler BK, Berger W. Abstract C93: Novel monosubstituted oxaliplatin analogs with improved characteristics Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C93 |
0.352 |
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| 2009 |
Heffeter P, Atil B, Jungwirth U, Koerner W, Micksche M, Keppler BK, Berger W. Abstract C103: In vitro and in vivo anticancer activity of the new ruthenium compound KP1339 against human liver cancer models Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C103 |
0.34 |
|
| 2009 |
Trondl R, Kowol CR, Arion VB, Jakupec MA, Lichtscheidl I, Keppler BK. Abstract C101: Subcellular distribution study by means of the inherent fluorescence of the investigational drug Triapine and its zinc(II) complex Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C101 |
0.401 |
|
| 2009 |
Fleischer A, Roller A, Arion VB, Keppler BK, Mohr F. Synthesis and structures of palladium(II) and platinum(II) complexes containing heterocyclic thiolate ligands formed by cycloaddition reactions of coordinated azides Canadian Journal of Chemistry. 87: 146-150. DOI: 10.1139/V08-115 |
0.36 |
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| 2009 |
Mendoza-Ferri MG, Hartinger CG, Nazarov AA, Eichinger RE, Jakupec MA, Severin K, Keppler BK. Influence of the arene ligand, the number and type of metal centers, and the leaving group on the in vitro antitumor activity of polynuclear organometallic compounds Organometallics. 28: 6260-6265. DOI: 10.1021/Om900715J |
0.424 |
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| 2009 |
Kandioller W, Hartinger CG, Nazarov AA, Kuznetsov ML, John RO, Bartel C, Jakupec MA, Arion VB, Keppler BK. From Pyrone to Thiopyrone Ligands−Rendering Maltol-Derived Ruthenium(II)−Arene Complexes That Are Anticancer Active in Vitro Organometallics. 28: 4249-4251. DOI: 10.1021/Om900483T |
0.375 |
|
| 2009 |
Renfrew AK, Phillips AD, Egger AE, Hartinger CG, Bosquain SS, Nazarov AA, Keppler BK, Gonsalvi L, Peruzzini M, Dyson PJ. Influence of Structural Variation on the Anticancer Activity of RAPTA-Type Complexes: ptn versus pta Organometallics. 28: 1165-1172. DOI: 10.1021/Om800899E |
0.402 |
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| 2009 |
Kandioller W, Hartinger CG, Nazarov AA, Kasser J, John R, Jakupec MA, Arion VB, Dyson PJ, Keppler BK. Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moiety Journal of Organometallic Chemistry. 694: 922-929. DOI: 10.1016/J.Jorganchem.2008.10.016 |
0.446 |
|
| 2009 |
Biba F, Groessl M, Egger A, Roller A, Hartinger CG, Keppler BK. New Insights into the Chemistry of the Antineoplastic Lanthanum Complex Tris(1,10-phenanthroline)tris(thiocyanato-κN)lanthanum(III) (KP772) and Its Interaction with Biomolecules European Journal of Inorganic Chemistry. 2009: 4282-4287. DOI: 10.1002/Ejic.200900038 |
0.44 |
|
| 2008 |
Kowol CR, Reisner E, Chiorescu I, Arion VB, Galanski M, Deubel DV, Keppler BK. An electrochemical study of antineoplastic gallium, iron and ruthenium complexes with redox noninnocent α-N-heterocyclic chalcogensemicarbazones Inorganic Chemistry. 47: 11032-11047. PMID 18973290 DOI: 10.1021/Ic8013249 |
0.609 |
|
| 2008 |
Reithofer MR, Valiahdi SM, Galanski M, Jakupec MA, Arion VB, Keppler BK. Novel Endothall‐Containing Platinum(IV) Complexes: Synthesis, Characterization, and Cytotoxic Activity Chemistry & Biodiversity. 5: 2160-2170. PMID 18972539 DOI: 10.1002/Cbdv.200890197 |
0.414 |
|
| 2008 |
Ashraf SM, Kandioller W, Mendoza-Ferri M, Nazarov AA, Hartinger CG, Keppler BK. The Hydration of Chloroacetonitriles Catalyzed by Mono- and Dinuclear Ru II - and Os II -Arene Complexes Chemistry & Biodiversity. 5: 2060-2066. PMID 18972538 DOI: 10.1002/Cbdv.200890188 |
0.407 |
|
| 2008 |
Hartinger CG, Jakupec MA, Zorbas-Seifried S, Groessl M, Egger A, Berger W, Zorbas H, Dyson PJ, Keppler BK. KP1019, a new redox-active anticancer agent--preclinical development and results of a clinical phase I study in tumor patients. Chemistry & Biodiversity. 5: 2140-55. PMID 18972504 DOI: 10.1002/Cbdv.200890195 |
0.331 |
|
| 2008 |
Hartinger CG, Nazarov AA, Ashraf SM, Dyson PJ, Keppler BK. Carbohydrate-metal complexes and their potential as anticancer agents. Current Medicinal Chemistry. 15: 2574-91. PMID 18855680 DOI: 10.2174/092986708785908978 |
0.425 |
|
| 2008 |
Reithofer MR, Schwarzinger A, Valiahdi SM, Galanski M, Jakupec MA, Keppler BK. Novel bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) complexes with exceptionally high cytotoxicity. Journal of Inorganic Biochemistry. 102: 2072-2077. PMID 18755512 DOI: 10.1016/J.Jinorgbio.2008.07.006 |
0.41 |
|
| 2008 |
Ashraf SM, Berger I, Nazarov AA, Hartinger CG, Koroteev MP, Nifant'ev EE, Keppler BK. Phosphite-derivatized ruthenium-carbohydrate complexes in the catalytic hydration of nitriles. short communication. Chemistry & Biodiversity. 5: 1640-1644. PMID 18729099 DOI: 10.1002/Cbdv.200890151 |
0.378 |
|
| 2008 |
Egger A, Cebrián‐Losantos B, Stepanenko IN, Krokhin AA, Eichinger R, Jakupec MA, Arion VB, Keppler BK. Hydrolysis and cytotoxic properties of osmium(II)/(III)-DMSO-azole complexes. Short communication. Chemistry & Biodiversity. 5: 1588-1593. PMID 18729098 DOI: 10.1002/Cbdv.200890146 |
0.44 |
|
| 2008 |
Groessl M, Hartinger CG, Połeć-Pawlak K, Jarosz M, Dyson PJ, Keppler BK. Elucidation of the interactions of an anticancer ruthenium complex in clinical trials with biomolecules utilizing capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry. Short communication. Chemistry & Biodiversity. 5: 1609-14. PMID 18729095 DOI: 10.1002/Cbdv.200890148 |
0.392 |
|
| 2008 |
Dolfen D, Schottler K, Valiahdi SM, Jakupec MA, Keppler BK, Tiekink ER, Mohr F. Synthesis, structures and in vitro cytotoxicity of some platinum(II) complexes containing thiocarbamate esters. Journal of Inorganic Biochemistry. 102: 2067-71. PMID 18707761 DOI: 10.1016/J.Jinorgbio.2008.07.002 |
0.447 |
|
| 2008 |
Berger I, Hanif M, Nazarov AA, Hartinger CG, John RO, Kuznetsov ML, Groessl M, Schmitt F, Zava O, Biba F, Arion VB, Galanski M, Jakupec MA, Juillerat-Jeanneret L, Dyson PJ, ... Keppler BK, et al. In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 9046-57. PMID 18688905 DOI: 10.1002/Chem.200801032 |
0.423 |
|
| 2008 |
Scolaro C, Hartinger CG, Allardyce CS, Keppler BK, Dyson PJ. Hydrolysis study of the bifunctional antitumour compound RAPTA-C, [Ru(eta6-p-cymene)Cl2(pta)]. Journal of Inorganic Biochemistry. 102: 1743-8. PMID 18582946 DOI: 10.1016/J.Jinorgbio.2008.05.004 |
0.35 |
|
| 2008 |
Cebrián-Losantos B, Reisner E, Kowol CR, Roller A, Shova S, Arion VB, Keppler BK. Synthesis and reactivity of the aquation product of the antitumor complex trans-[Ru(III)Cl4(indazole)2]-. Inorganic Chemistry. 47: 6513-23. PMID 18553904 DOI: 10.1021/Ic800506G |
0.628 |
|
| 2008 |
Groessl M, Hartinger CG, Polec-Pawlak K, Jarosz M, Keppler BK. Capillary electrophoresis hyphenated to inductively coupled plasma-mass spectrometry: A novel approach for the analysis of anticancer metallodrugs in human serum and plasma Electrophoresis. 29: 2224-2232. PMID 18512673 DOI: 10.1002/Elps.200780790 |
0.342 |
|
| 2008 |
Połeć-Pawlak K, Abramski JK, Ferenc J, Foteeva LS, Timerbaev AR, Keppler BK, Jarosz M. Application of capillary electrophoresis-inductively coupled plasma mass spectrometry to comparative studying of the reactivity of antitumor ruthenium(III) complexes differing in the nature of counter-ion toward human serum proteins. Journal of Chromatography A. 1192: 323-326. PMID 18433763 DOI: 10.1016/J.Chroma.2008.04.009 |
0.349 |
|
| 2008 |
Heffeter P, Jungwirth U, Jakupec M, Hartinger C, Galanski M, Elbling L, Micksche M, Keppler B, Berger W. Resistance against novel anticancer metal compounds: Differences and similarities Drug Resistance Updates. 11: 1-16. PMID 18394950 DOI: 10.1016/J.Drup.2008.02.002 |
0.327 |
|
| 2008 |
Reithofer MR, Galanski M, Arion VB, Keppler BK. Unprecedented twofold intramolecular hydroamination in diam(m)ine-dicarboxylatodichloridoplatinum(IV) complexes - ethane-1,2-diamine vs. ammine ligands. Chemical Communications. 1091-3. PMID 18292900 DOI: 10.1039/B715680D |
0.365 |
|
| 2008 |
Jakupec MA, Galanski M, Arion VB, Hartinger CG, Keppler BK. Antitumour metal compounds: more than theme and variations. Dalton Transactions. 183-94. PMID 18097483 DOI: 10.1039/B712656P |
0.411 |
|
| 2008 |
Dorcier A, Hartinger CG, Scopelliti R, Fish RH, Keppler BK, Dyson PJ. Studies on the reactivity of organometallic Ru-, Rh- and Os-pta complexes with DNA model compounds Journal of Inorganic Biochemistry. 102: 1066-1076. PMID 18086499 DOI: 10.1016/J.Jinorgbio.2007.10.016 |
0.392 |
|
| 2008 |
Ginzinger W, Arion VB, Giester G, Galanski M, Keppler BK. Synthesis and structural peculiarities of gallium Complexes with novel paullone derivatives Central European Journal of Chemistry. 6: 340-346. DOI: 10.2478/S11532-008-0048-X |
0.401 |
|
| 2008 |
Schuecker R, John RO, Jakupec MA, Arion VB, Keppler BK. Water-Soluble Mixed-Ligand Ruthenium(II) and Osmium(II) Arene Complexes with High Antiproliferative Activity Organometallics. 27: 6587-6595. DOI: 10.1021/Om800774T |
0.392 |
|
| 2008 |
Mendoza-Ferri MG, Hartinger CG, Eichinger RE, Stolyarova N, Severin K, Jakupec MA, Nazarov AA, Keppler BK. Influence of the spacer length on the in vitro anticancer activity of dinuclear ruthenium arene compounds Organometallics. 27: 2405-2407. DOI: 10.1021/Om800207T |
0.378 |
|
| 2008 |
Chiorescu I, Deubel DV, Ariotn VB, Keppler BK. Computational electrochemistry of ruthenium anticancer agents. Unprecedented benchmarking of implicit solvation methods Journal of Chemical Theory and Computation. 4: 499-506. DOI: 10.1021/Ct700247G |
0.373 |
|
| 2008 |
Habala L, Dworak C, Nazarov AA, Hartinger CG, Abramkin SA, Arion VB, Lindner W, Galanski M, Keppler BK. Methyl-substituted trans-1,2-cyclohexanediamines as new ligands for oxaliplatin-type complexes Tetrahedron. 64: 137-146. DOI: 10.1016/J.Tet.2007.10.069 |
0.37 |
|
| 2008 |
Reisner E, Arion VB, Keppler BK, Pombeiro AJ. Electron-transfer activated metal-based anticancer drugs Inorganica Chimica Acta. 361: 1569-1583. DOI: 10.1016/J.Ica.2006.12.005 |
0.587 |
|
| 2008 |
Dobrov A, Arion VB, Shova S, Roller A, Rentschler E, Keppler BK. Spontaneous resolution of a triple-stranded dinickel(II) helicate generated via intermolecular transamination reaction of S-methylisothiocarbohydrazide in the presence of Ni2+ European Journal of Inorganic Chemistry. 4140-4145. DOI: 10.1002/Ejic.200800605 |
0.327 |
|
| 2008 |
Mendoza-Ferri MG, Hartinger CG, Nazarov AA, Kandioller W, Severin K, Keppler BK. Modifying the structure of dinuclear ruthenium complexes with antitumor activity Applied Organometallic Chemistry. 22: 326-332. DOI: 10.1002/Aoc.1394 |
0.451 |
|
| 2007 |
Groessl M, Hartinger CG, Dyson PJ, Keppler BK. CZE-ICP-MS as a tool for studying the hydrolysis of ruthenium anticancer drug candidates and their reactivity towards the DNA model compound dGMP. Journal of Inorganic Biochemistry. 102: 1060-5. PMID 18222004 DOI: 10.1016/J.Jinorgbio.2007.11.018 |
0.353 |
|
| 2007 |
Reithofer MR, Valiahdi SM, Jakupec MA, Arion VB, Egger A, Galanski M, Keppler BK. Novel Di- and Tetracarboxylatoplatinum(IV) Complexes. Synthesis, Characterization, Cytotoxic Activity, and DNA Platination Journal of Medicinal Chemistry. 50: 6692-6699. PMID 18031001 DOI: 10.1021/Jm070897B |
0.441 |
|
| 2007 |
Schmid WF, John RO, Mühlgassner G, Heffeter P, Jakupec MA, Galanski M, Berger W, Arion VB, Keppler BK. Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy. Journal of Medicinal Chemistry. 50: 6343-55. PMID 17997519 DOI: 10.1021/Jm701042W |
0.428 |
|
| 2007 |
Scolaro C, Chaplin AB, Hartinger CG, Bergamo A, Cocchietto M, Keppler BK, Sava G, Dyson PJ. Tuning the hydrophobicity of ruthenium(II)-arene (RAPTA) drugs to modify uptake, biomolecular interactions and efficacy. Dalton Transactions (Cambridge, England : 2003). 5065-72. PMID 17992291 DOI: 10.1039/B705449A |
0.377 |
|
| 2007 |
Hartinger CG, Keppler BK. CE in anticancer metallodrug research--an update. Electrophoresis. 28: 3436-3446. PMID 17847132 DOI: 10.1002/Elps.200700114 |
0.36 |
|
| 2007 |
Kowol CR, Eichinger R, Jakupec MA, Galanski M, Arion VB, Keppler BK. Effect of metal ion complexation and chalcogen donor identity on the antiproliferative activity of 2-acetylpyridine N,N-dimethyl(chalcogen)semicarbazones. Journal of Inorganic Biochemistry. 101: 1946-1957. PMID 17825917 DOI: 10.1016/J.Jinorgbio.2007.07.026 |
0.358 |
|
| 2007 |
Gelmboldt VO, Ganin EV, Fonari MS, Simonov YA, Koroeva LV, Ennan AA, Basok SS, Shova S, Kählig H, Arion VB, Keppler BK. Two new “onium” fluorosilicates, the products of interaction of fluorosilicic acid with 12-membered macrocycles: structures and spectroscopic properties Dalton Transactions. 2007: 2915-2924. PMID 17607406 DOI: 10.1039/B703645K |
0.306 |
|
| 2007 |
Timerbaev AR, Foteeva LS, Rudnev AV, Abramski JK, Połeć‐Pawlak K, Hartinger CG, Jarosz M, Keppler BK. Probing the stability of serum protein-ruthenium(III) drug adducts in the presence of extracellular reductants using CE. Electrophoresis. 28: 2235-2240. PMID 17557359 DOI: 10.1002/Elps.200600707 |
0.357 |
|
| 2007 |
Cebrian-Losantos B, Krokhin AA, Stepanenko IN, Eichinger R, Jakupec MA, Arion VB, Keppler BK. Osmium NAMI-A analogues: synthesis, structural and spectroscopic characterization, and antiproliferative properties. Inorganic Chemistry. 46: 5023-5033. PMID 17497853 DOI: 10.1021/Ic700405Y |
0.425 |
|
| 2007 |
Scaffidi-Domianello YY, Nazarov AA, Haukka M, Galanski M, Keppler BK, Schneider J, Du P, Eisenberg R, Kukushkin VY. First example of the solid-state thermal cyclometalation of ligated benzophenone imine giving novel luminescent platinum(II) species. Inorganic Chemistry. 46: 4469-82. PMID 17451237 DOI: 10.1021/Ic062414K |
0.396 |
|
| 2007 |
Heffeter P, Jakupec MA, Körner W, Chiba P, Pirker C, Dornetshuber R, Elbling L, Sutterlüty H, Micksche M, Keppler BK, Berger W. Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24). Biochemical Pharmacology. 73: 1873-1886. PMID 17445775 DOI: 10.1016/J.Bcp.2007.03.002 |
0.315 |
|
| 2007 |
Schmid WF, Zorbas-Seifried S, John RO, Arion VB, Jakupec MA, Roller A, Galanski M, Chiorescu I, Zorbas H, Keppler BK. The first ruthenium-based paullones: syntheses, X-ray diffraction structures, and spectroscopic and antiproliferative properties in vitro. Inorganic Chemistry. 46: 3645-56. PMID 17402728 DOI: 10.1021/Ic070098J |
0.309 |
|
| 2007 |
Groessl M, Reisner E, Hartinger CG, Eichinger R, Semenova O, Timerbaev AR, Jakupec MA, Arion VB, Keppler BK. Structure-activity relationships for NAMI-A-type complexes (HL)[trans-RuCl4L(S-dmso)ruthenate(III)] (L = imidazole, indazole, 1,2,4-triazole, 4-amino-1,2,4-triazole, and 1-methyl-1,2,4-triazole): aquation, redox properties, protein binding, and antiproliferative activity. Journal of Medicinal Chemistry. 50: 2185-93. PMID 17402720 DOI: 10.1021/Jm061081Y |
0.64 |
|
| 2007 |
Timerbaev AR, Vasylenko OO, Foteeva LS, Rudnev AV, Semenova O, Keppler BK. Application of micellar and microemulsion electrokinetic chromatography for characterization of gallium(III) complexes of pharmaceutical significance. Ieee Journal of Solid-State Circuits. 30: 399-406. PMID 17396599 DOI: 10.1002/Jssc.200600305 |
0.392 |
|
| 2007 |
Berger I, Nazarov AA, Hartinger CG, Groessl M, Valiahdi S, Jakupec MA, Keppler BK. A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin? Chemmedchem. 2: 505-514. PMID 17340670 DOI: 10.1002/Cmdc.200600279 |
0.462 |
|
| 2007 |
Kowol CR, Berger R, Eichinger R, Roller A, Jakupec MA, Schmidt PP, Arion VB, Keppler BK. Gallium(III) and Iron(III) Complexes of α-N-Heterocyclic Thiosemicarbazones: Synthesis, Characterization, Cytotoxicity, and Interaction with Ribonucleotide Reductase Journal of Medicinal Chemistry. 50: 1254-1265. PMID 17315858 DOI: 10.1021/Jm0612618 |
0.367 |
|
| 2007 |
Galanski M, Keppler BK. Searching for the magic bullet: anticancer platinum drugs which can be accumulated or activated in the tumor tissue. Anti-Cancer Agents in Medicinal Chemistry. 7: 55-73. PMID 17266505 DOI: 10.2174/187152007779314017 |
0.347 |
|
| 2007 |
Aleksenko SS, Hartinger CG, Semenova O, Meelich K, Timerbaev AR, Keppler BK. Characterization of interactions between human serum albumin and tumor-inhibiting amino alcohol platinum(II) complexes using capillary electrophoresis. Journal of Chromatography A. 1155: 218-221. PMID 17240384 DOI: 10.1016/J.Chroma.2007.01.017 |
0.415 |
|
| 2007 |
Zorbas-Seifried S, Jakupec MA, Kukushkin NV, Groessl M, Hartinger CG, Semenova O, Zorbas H, Kukushkin VY, Keppler BK. Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands. Molecular Pharmacology. 71: 357-65. PMID 17050805 DOI: 10.1124/Mol.106.030726 |
0.416 |
|
| 2007 |
Hartinger CG, Ang WH, Casini A, Messori L, Keppler BK, Dyson PJ. Mass spectrometric analysis of ubiquitin–platinum interactions of leading anticancer drugs: MALDI versus ESI Journal of Analytical Atomic Spectrometry. 22: 960-967. DOI: 10.1039/B703350H |
0.345 |
|
| 2007 |
Schmid WF, John RO, Arion VB, Jakupec MA, Keppler BK. Highly Antiproliferative Ruthenium(II) and Osmium(II) Arene Complexes with Paullone-Derived Ligands Organometallics. 26: 6643-6652. DOI: 10.1021/Om700813C |
0.452 |
|
| 2007 |
Budzisz E, Malecka M, Keppler BK, Arion VB, Andrijewski G, Krajewska U, Rozalski M. Synthesis, Structure, Protolytic Properties, Alkylating and Cytotoxic Activity of Novel Platinum(II) and Palladium(II) Complexes with Pyrazole-Derived Ligands European Journal of Inorganic Chemistry. 2007: 3728-3735. DOI: 10.1002/Ejic.200700139 |
0.455 |
|
| 2007 |
Grguric-Sipka S, Kowol CR, Valiahdi S, Eichinger R, Jakupec MA, Roller A, Shova S, Arion VB, Keppler BK. Ruthenium(II) Complexes of Thiosemicarbazones: The First Water-Soluble Complex with pH-Dependent Antiproliferative Activity European Journal of Inorganic Chemistry. 2007: 2870-2878. DOI: 10.1002/Ejic.200601196 |
0.422 |
|
| 2007 |
Stepanenko IN, Cebrián‐Losantos B, Arion VB, Krokhin AA, Nazarov AA, Keppler BK. The Complexes [OsCl2(azole)2(dmso)2] and [OsCl2(azole)(dmso)3]: Synthesis, Structure, Spectroscopic Properties and Catalytic Hydration of Chloronitriles European Journal of Inorganic Chemistry. 2007: 400-411. DOI: 10.1002/Ejic.200600859 |
0.428 |
|
| 2007 |
Berger I, Nazarov AA, Hartinger CG, Groessl M, Valiahdi S, Jakupec MA, Keppler BK. Cover Picture: A glucose derivative as natural alternative to the cyclohexane‐1,2‐diamine ligand in the anticancer drug oxaliplatin? (ChemMedChem 4/2007) Chemmedchem. 2: 385-385. DOI: 10.1002/Cmdc.200790008 |
0.303 |
|
| 2006 |
Zorbas-Seifried S, Hartinger CG, Meelich K, Galanski M, Keppler BK, Zorbas H. DNA interactions of pH-sensitive, antitumor bis(aminoalcohol) dichloroplatinum(II) complexes Biochemistry. 45: 14817-14825. PMID 17144675 DOI: 10.1021/Bi061063I |
0.353 |
|
| 2006 |
Rudnev AV, Foteeva LS, Kowol C, Berger R, Jakupec MA, Arion VB, Timerbaev AR, Keppler BK. Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins. Journal of Inorganic Biochemistry. 100: 1819-1826. PMID 16938349 DOI: 10.1016/J.Jinorgbio.2006.07.003 |
0.44 |
|
| 2006 |
Hartinger CG, Zorbas-Seifried S, Jakupec MA, Kynast B, Zorbas H, Keppler BK. From bench to bedside – preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A) Journal of Inorganic Biochemistry. 100: 891-904. PMID 16603249 DOI: 10.1016/J.Jinorgbio.2006.02.013 |
0.351 |
|
| 2006 |
Schluga P, Hartinger CG, Egger A, Reisner E, Galanski M, Jakupec MA, Keppler BK. Redox behavior of tumor-inhibiting ruthenium(III) complexes and effects of physiological reductants on their binding to GMP. Dalton Transactions (Cambridge, England : 2003). 1796-802. PMID 16568190 DOI: 10.1039/B511792E |
0.605 |
|
| 2006 |
Dobrov A, Arion VB, Kandler N, Ginzinger W, Jakupec MA, Rufinska A, Keyserlingk NGV, Galanski M, Kowol C, Keppler BK. The first metal-based paullone derivative with high antiproliferative activity in vitro. Inorganic Chemistry. 45: 1945-1950. PMID 16499355 DOI: 10.1021/Ic0511120 |
0.393 |
|
| 2006 |
Polec‐Pawlak K, Abramski JK, Semenova O, Hartinger CG, Timerbaev AR, Keppler BK, Jarosz M. Platinum group metallodrug-protein binding studies by capillary electrophoresis - inductively coupled plasma-mass spectrometry: a further insight into the reactivity of a novel antitumor ruthenium(III) complex toward human serum proteins. Electrophoresis. 27: 1128-1135. PMID 16440400 DOI: 10.1002/Elps.200500694 |
0.347 |
|
| 2006 |
Heffeter P, Jakupec MA, Körner W, Wild S, Keyserlingk NGv, Elbling L, Zorbas H, Korynevska A, Knasmüller S, Sutterlüty H, Micksche M, Keppler BK, Berger W. Anticancer activity of the lanthanum compound [tris(1,10-phenanthroline)lanthanum(III)]trithiocyanate (KP772; FFC24). Biochemical Pharmacology. 71: 426-440. PMID 16343446 DOI: 10.1016/J.Bcp.2005.11.009 |
0.367 |
|
| 2006 |
Huang Z, Timerbaev AR, Keppler BK, Hirokawa T. Determination of cisplatin and its hydrolytic metabolite in human serum by capillary electrophoresis techniques. Journal of Chromatography. A. 1106: 75-9. PMID 16203005 DOI: 10.1016/J.Chroma.2005.09.042 |
0.316 |
|
| 2006 |
Reisner E, Arion VB, Eichinger A, Kandler N, Giester G, Pombeiro AJ, Keppler BK. Tuning of redox properties for the design of ruthenium anticancer drugs: part 2. Syntheses, crystal structures, and electrochemistry of potentially antitumor [Ru III/II Cl6-n(Azole)n]z(n = 3, 4, 6) complexes. Inorganic Chemistry. 44: 6704-16. PMID 16156629 DOI: 10.1021/Ic0503737 |
0.625 |
|
| 2006 |
Heffeter P, Jakupec MA, Körner W, Chiba P, Dornetshuber R, Elbling L, Sutterlüty H, Micksche M, Keppler BK, Berger W. 180 POSTER Enhanced anticancer activity of [Tris(1,10-phenanthroline)-lanthanum(III)]-trithiocyanate (KP772; FFC24) against ABC-transporter-overexpressing cells Ejc Supplements. 4: 57. DOI: 10.1016/S1359-6349(06)70185-9 |
0.305 |
|
| 2006 |
Hartinger CG, Ferri-Mendoza MG, Nazarov AA, Keppler BK. Electrospray ionization mass spectrometric study on the coordination behavior of dacarbazine towards transition metal ions Polyhedron. 25: 1971-1978. DOI: 10.1016/J.Poly.2005.12.022 |
0.441 |
|
| 2006 |
Rothenburger C, Galanski M, Arion VB, Görls H, Weigand W, Keppler BK. Synthesis and Characterization of [(1R,2R)-trans-Diaminocyclohexane]platinum(II) Coordinated to Sulfur and Selenium Amino Acids European Journal of Inorganic Chemistry. 2006: 3746-3752. DOI: 10.1002/Ejic.200600453 |
0.329 |
|
| 2006 |
Meelich K, Galanski M, Arion VB, Keppler BK. Bis(2-amino alcohol-κN)dicarboxylatoplatinum(II) Complexes – Elegant Synthesis via Ring-Opening of Bis(2-amino alcoholato-κ2N,O)platinum(II) Species with Dicarboxylic Acids European Journal of Inorganic Chemistry. 2006: 2476-2483. DOI: 10.1002/Ejic.200600193 |
0.402 |
|
| 2006 |
Reithofer M, Galanski M, Roller A, Keppler BK. An Entry to Novel Platinum Complexes: Carboxylation of Dihydroxoplatinum(IV) Complexes with Succinic Anhydride and Subsequent Derivatization European Journal of Inorganic Chemistry. 2006: 2612-2617. DOI: 10.1002/Ejic.200600108 |
0.417 |
|
| 2005 |
Galanski M, Slaby S, Jakupec MA, Keppler BK. Synthesis and in vitro Antitumor Potency of(Cyclohexane-1,2-Diamine)Platinum(II) Complexeswith Aminotris(Methylenephosphonic Acid) as Bone-Seeking Ligand Bioinorganic Chemistry and Applications. 3: 179-190. PMID 18365098 DOI: 10.1155/Bca.2005.179 |
0.43 |
|
| 2005 |
Schluga P, Hartinger CG, Galanski M, Meelich K, Timerbaev AR, Keppler BK. Tumour-inhibiting platinum(II) complexes with aminoalcohol ligands : biologically important transformations studied by micellar electrokinetic chromatography, nuclear magnetic resonance spectroscopy and mass spectrometry Analyst. 130: 1383-1389. PMID 16172663 DOI: 10.1039/B506490B |
0.407 |
|
| 2005 |
Galanski M, Jakupec MA, Keppler BK. Update of the preclinical situation of anticancer platinum complexes: novel design strategies and innovative analytical approaches. Current Medicinal Chemistry. 12: 2075-2094. PMID 16101495 DOI: 10.2174/0929867054637626 |
0.389 |
|
| 2005 |
Habala L, Galanski M, Yasemi A, Nazarov AA, Keyserlingk NGv, Keppler BK. Synthesis and structure-activity relationships of mono- and dialkyl-substituted oxaliplatin derivatives European Journal of Medicinal Chemistry. 40: 1149-1155. PMID 16040163 DOI: 10.1016/J.Ejmech.2005.06.003 |
0.392 |
|
| 2005 |
Kapitza S, Jakupec MA, Uhl M, Keppler BK, Marian B. The heterocyclic ruthenium(III) complex KP1019 (FFC14A) causes DNA damage and oxidative stress in colorectal tumor cells Cancer Letters. 226: 115-121. PMID 16039951 DOI: 10.1016/J.Canlet.2005.01.002 |
0.302 |
|
| 2005 |
Reisner E, Arion VB, Rufi?ska A, Chiorescu I, Schmid WF, Keppler BK. Isomeric [RuCl2(dmso)2(indazole)2] complexes: ruthenium(II)-mediated coupling reaction of acetonitrile with 1H-indazole. Dalton Transactions (Cambridge, England : 2003). 2355-64. PMID 15995743 DOI: 10.1039/B503650J |
0.613 |
|
| 2005 |
Timerbaev AR, Rudnev AV, Semenova O, Hartinger CG, Keppler BK. Comparative binding of antitumor indazolium [trans-tetrachlorobis(1H-indazole)ruthenate(III)] to serum transport proteins assayed by capillary zone electrophoresis. Analytical Biochemistry. 341: 326-333. PMID 15907879 DOI: 10.1016/J.Ab.2005.03.020 |
0.378 |
|
| 2005 |
Jakupec MA, Reisner E, Eichinger A, Pongratz M, Arion VB, Galanski M, Hartinger CG, Keppler BK. Redox-active antineoplastic ruthenium complexes with indazole: correlation of in vitro potency and reduction potential. Journal of Medicinal Chemistry. 48: 2831-7. PMID 15828821 DOI: 10.1021/Jm0490742 |
0.629 |
|
| 2005 |
Rudnev AV, Aleksenko SS, Semenova O, Hartinger CG, Timerbaev AR, Keppler BK. Determination of binding constants and stoichiometries for platinum anticancer drugs and serum transport proteins by capillary electrophoresis using the Hummel‐Dreyer method Ieee Journal of Solid-State Circuits. 28: 121-127. PMID 15754818 DOI: 10.1002/Jssc.200401930 |
0.312 |
|
| 2005 |
Rappel C, Galanski M, Yasemi A, Habala L, Keppler BK. Analysis of anticancer platinum(II)-complexes by microemulsion electrokinetic chromatography: separation of diastereomers and estimation of octanol-water partition coefficients. Electrophoresis. 26: 878-884. PMID 15714548 DOI: 10.1002/Elps.200410053 |
0.337 |
|
| 2005 |
Egger A, Arion VB, Reisner E, Cebrián-Losantos B, Shova S, Trettenhahn G, Keppler BK. Reactions of potent antitumor complex trans-[Ru(III)Cl4(indazole)2]- with a DNA-relevant nucleobase and thioethers: insight into biological action. Inorganic Chemistry. 44: 122-32. PMID 15627368 DOI: 10.1021/Ic048967H |
0.616 |
|
| 2005 |
Kapitza S, Pongratz M, Jakupec MA, Heffeter P, Berger W, Lackinger L, Keppler BK, Marian B. Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells Journal of Cancer Research and Clinical Oncology. 131: 101-110. PMID 15503135 DOI: 10.1007/S00432-004-0617-0 |
0.378 |
|
| 2005 |
Heffeter P, Pongratz M, Steiner E, Chiba P, Jakupec MA, Elbling L, Marian B, Körner W, Sevelda F, Micksche M, Keppler BK, Berger W. Intrinsic and acquired forms of resistance against the anticancer ruthenium compound KP1019 [indazolium trans-[tetrachlorobis(1H-indazole)ruthenate (III)] (FFC14A). Journal of Pharmacology and Experimental Therapeutics. 312: 281-289. PMID 15331656 DOI: 10.1124/Jpet.104.073395 |
0.301 |
|
| 2005 |
Dittrich C, Hochhaus A, Schaad S, Salama C, Jaehde U, Jakupec MA, Hauses M, Gneist M, Keppler BK. Phase I and pharmacokinetic study of the oral tris-(8-quinolinolato)gallium(III) complex (FFC11, KP46) in patients with solid tumors - a study of the CESAR Central European Society for Anticancer Drug Research - EWIV Journal of Clinical Oncology. 23: 3205-3205. DOI: 10.1200/Jco.2005.23.16_Suppl.3205 |
0.303 |
|
| 2005 |
Sulyok M, Hann S, Hartinger CG, Keppler BK, Stingeder G, Koellensperger G. Two dimensional separation schemes for investigation of the interaction of an anticancer ruthenium(III) compound with plasma proteins Journal of Analytical Atomic Spectrometry. 20: 856-863. DOI: 10.1039/B508060F |
0.327 |
|
| 2005 |
Nazarov AA, Koroteev MP, Hartinger CG, Keppler BK, Nifant'ev EE. Bis- and tris-bicyclophosphites of d-glucofuranoside. Unexpected catalysis of P(III/V)-oxidation by triethylamine Tetrahedron. 61: 10943-10950. DOI: 10.1016/J.Tet.2005.08.102 |
0.305 |
|
| 2005 |
Galanski M, Yasemi A, Jakupec MA, Keyserlingk NGv, Keppler BK. Synthesis, Cytotoxicity, and Structure-Activity Relationships of New Oxaliplatin Derivatives Monatshefte Fur Chemie. 136: 693-700. DOI: 10.1007/S00706-004-0241-3 |
0.398 |
|
| 2005 |
Nazarov AA, Koroteev MP, Hartinger CG, Keppler BK, Nifant’ev EE. On the Coordination Properties of New Bicyclophosphite-Carbohydrates Monatshefte Fur Chemie. 136: 137-146. DOI: 10.1007/S00706-004-0238-Y |
0.361 |
|
| 2005 |
Hartinger CG, Nazarov AA, Arion VB, Giester G, Kuznetsov ML, Galanski M, Keppler BK. 1,1'‐Bis(oxazolin‐2‐yl)ferrocenes: An Investigation of Their Complexation Behavior toward [Pd(η3‐allyl)Cl]2 European Journal of Inorganic Chemistry. 2005: 1589-1600. DOI: 10.1002/Ejic.200400737 |
0.344 |
|
| 2004 |
Kynast B, Graf V Keyserlingk N, Hauses M, Heffeter P, Jakupec M, Unfried P, Berger W, Keppler BK. Novel tumor-inhibiting metal complexes: Preclinical efficacy and toxicity of the lanthanum(III) complex [tris(1,10-phenantroline)lanthanum]trithiocyanate FFC24. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 3166. PMID 28014953 DOI: 10.1200/Jco.2004.22.14_Suppl.3166 |
0.438 |
|
| 2004 |
Jakupec MA, Keppler BK. Gallium in cancer treatment. Current Topics in Medicinal Chemistry. 4: 1575-1583. PMID 15579097 DOI: 10.2174/1568026043387449 |
0.366 |
|
| 2004 |
Warnke U, Rappel C, Meier H, Kloft C, Galanski M, Hartinger CG, Keppler BK, Jaehde U. Analysis of platinum adducts with DNA nucleotides and nucleosides by capillary electrophoresis coupled to ESI-MS: indications of guanosine 5'-monophosphate O6-N7 chelation. Chembiochem : a European Journal of Chemical Biology. 5: 1543-9. PMID 15515088 DOI: 10.1002/Cbic.200400015 |
0.311 |
|
| 2004 |
Reisner E, Arion VB, Guedes da Silva MF, Lichtenecker R, Eichinger A, Keppler BK, Kukushkin VY, Pombeiro AJ. Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole. Inorganic Chemistry. 43: 7083-93. PMID 15500346 DOI: 10.1021/Ic049479C |
0.606 |
|
| 2004 |
Galanski M, Yasemi A, Slaby S, Jakupec MA, Arion VB, Rausch M, Nazarov AA, Keppler BK. Synthesis, crystal structure and cytotoxicity of new oxaliplatin analogues indicating that improvement of anticancer activity is still possible. European Journal of Medicinal Chemistry. 39: 707-714. PMID 15276304 DOI: 10.1016/J.Ejmech.2004.04.003 |
0.356 |
|
| 2004 |
Timerbaev AR, Aleksenko SS, Polec-Pawlak K, Ruzik R, Semenova O, Hartinger CG, Oszwaldowski S, Galanski M, Jarosz M, Keppler BK. Platinum metallodrug-protein binding studies by capillary electrophoresis-inductively coupled plasma-mass spectrometry: characterization of interactions between Pt(II) complexes and human serum albumin. Electrophoresis. 25: 1988-1995. PMID 15237398 DOI: 10.1002/Elps.200305984 |
0.385 |
|
| 2004 |
Pongratz M, Schluga P, Jakupec MA, Arion VB, Hartinger CG, Allmaier G, Keppler BK. Transferrin binding and transferrin-mediated cellular uptake of the ruthenium coordination compound KP1019, studied by means of AAS, ESI-MS and CD spectroscopy Journal of Analytical Atomic Spectrometry. 19: 46-51. DOI: 10.1039/B309160K |
0.36 |
|
| 2004 |
Heffeter P, Jakupec MA, Micksche M, Hauses M, Keyserlingk NGv, Keppler BK, Berger W. 424 In vivo and in vitro anticancer activity of the lanthanum compound KP772 (FFC24) Ejc Supplements. 2: 127. DOI: 10.1016/S1359-6349(04)80432-4 |
0.319 |
|
| 2004 |
Galanski M, Baumgartner C, Meelich K, Arion VB, Fremuth M, Jakupec MA, Schluga P, Hartinger CG, Keyserlingk NGv, Keppler BK. Synthesis, crystal structure and pH dependent cytotoxicity of (SP-4-2)-bis(2-aminoethanolato-κ2N, O)platinum(II): a representative of novel pH sensitive anticancer platinum complexes Inorganica Chimica Acta. 357: 3237-3244. DOI: 10.1016/J.Ica.2004.04.003 |
0.314 |
|
| 2004 |
Budzisz E, Keppler BK, Giester G, Wozniczka M, Kufelnicki A, Nawrot B. Synthesis, Crystal Structure and Biological Characterization of a Novel Palladium(II) Complex with a Coumarin‐Derived Ligand European Journal of Inorganic Chemistry. 2004: 4412-4419. DOI: 10.1002/Ejic.200400483 |
0.424 |
|
| 2003 |
Galanski M, Slaby S, Jakupec MA, Keppler BK. Synthesis, Characterization, and in Vitro Antitumor Activity of Osteotropic Diam(m)ineplatinum(II) Complexes Bearing a N,N-Bis(phosphonomethyl)glycine Ligand† Journal of Medicinal Chemistry. 46: 4946-4951. PMID 14584945 DOI: 10.1021/Jm0308040 |
0.429 |
|
| 2003 |
Galanski M, Arion VB, Jakupec MA, Keppler BK. Recent Developments in the Field of Tumor-Inhibiting Metal Complexes Current Pharmaceutical Design. 9: 2078-2089. PMID 14529417 DOI: 10.2174/1381612033454180 |
0.4 |
|
| 2003 |
Arion VB, Reisner E, Fremuth M, Jakupec MA, Keppler BK, Kukushkin VY, Pombeiro AJ. Synthesis, X-ray diffraction structures, spectroscopic properties, and in vitro antitumor activity of isomeric (1H-1,2,4-triazole)Ru(III) complexes. Inorganic Chemistry. 42: 6024-31. PMID 12971773 DOI: 10.1021/Ic034605I |
0.599 |
|
| 2003 |
Hartinger CG, Schluga P, Galanski M, Baumgartner C, Timerbaev AR, Keppler BK. Tumor‐inhibiting platinum(II) complexes with aminoalcohol ligands: Comparison of the mode of action by capillary electrophoresis and electrospray ionization‐mass spectrometry Electrophoresis. 24: 2038-2044. PMID 12858373 DOI: 10.1002/Elps.200305463 |
0.388 |
|
| 2003 |
Hartinger CG, Timerbaev AR, Keppler BK. Capillary electrophoresis in anti-cancer metallodrug research: advances and future challenges. Electrophoresis. 24: 2023-2037. PMID 12858372 DOI: 10.1002/Elps.200305452 |
0.323 |
|
| 2003 |
Jakupec MA, Galanski M, Keppler BK. Tumour-inhibiting platinum complexes--state of the art and future perspectives. Reviews of Physiology Biochemistry and Pharmacology. 146: 1-53. PMID 12605304 DOI: 10.1007/S10254-002-0001-X |
0.326 |
|
| 2003 |
Hartinger CG, Nazarov AA, Chevchenko V, Arion VB, Galanski M, Keppler BK. Synthesis, crystal structures, and electrospray ionisation mass spectrometry investigations of ether- and thioether-substituted ferrocenes Dalton Transactions. 3098-3102. DOI: 10.1039/B304115H |
0.343 |
|
| 2003 |
Unfried P, Reisner E, Fremuth M, Jakupec MA, Lichtenecker R, Arion VB, Keppler BK. Two novel trans-tetrachloro(dimethyl sulfoxide)azoleruthenate(III) complexes, their antiproliferative activity and the coordination mode of triazole in H2trz[RuCl4(dmso)(Htrz)] Journal of Inorganic Biochemistry. 96: 243. DOI: 10.1016/S0162-0134(03)80793-6 |
0.593 |
|
| 2003 |
Arion VB, Reisner E, Fremuth M, Jakupec MA, Keppler BK, Kukushkin VY, Pombeiro AJ. Synthesis, structure, spectroscopic and in vitro anti-tumor properties of triazolium salts of cis- and trans-tetrachlorobis(triazole)ruthenate(III) Journal of Inorganic Biochemistry. 96: 95. DOI: 10.1016/S0162-0134(03)80556-1 |
0.544 |
|
| 2003 |
Arion VB, Galanski M, Zimmermann W, Berger M, Baumgartner C, Keppler BK. Carboxylation of 2-hydroxyethyl substituted tetrachloro(ethane-1,2-diamine)platinum(IV) complexes. A new synthetic approach to anticancer platinum compounds Journal of Inorganic Biochemistry. 96: 94. DOI: 10.1016/S0162-0134(03)80555-X |
0.408 |
|
| 2003 |
Arion VB, Galanski M, Baumgartner C, Meelich K, Fremuth M, Jakupec MA, Keppler BK. Bis(aminoalcohol)dichloroplatinum(II) complexes and their mono and double ring-closed alcoholato species. Novel prodrugs for platinum based antitumor chemotherapy Journal of Inorganic Biochemistry. 96: 93. DOI: 10.1016/S0162-0134(03)80554-8 |
0.375 |
|
| 2003 |
Galanski M, Baumgartner C, Arion V, Keppler BK. Bis(2-aminobutanol)dichloroplatinum(II) Complexes and Their Singly and Doubly Ring-Closed Butanolato Species − Novel Prodrugs for Platinum-Based Antitumour Chemotherapy? European Journal of Inorganic Chemistry. 2003: 2619-2625. DOI: 10.1002/Ejic.200300050 |
0.409 |
|
| 2002 |
Arion VB, Jakupec MA, Galanski M, Unfried P, Keppler BK. Synthesis, structure, spectroscopic and in vitro antitumour studies of a novel gallium(III) complex with 2-acetylpyridine 4N-dimethylthiosemicarbazone Journal of Inorganic Biochemistry. 91: 298-305. PMID 12121788 DOI: 10.1016/S0162-0134(02)00419-1 |
0.435 |
|
| 2002 |
Timerbaev AR, Küng A, Keppler BK. Capillary electrophoresis of platinum-group elements. Analytical, speciation and biochemical studies. Journal of Chromatography A. 945: 25-44. PMID 11860140 DOI: 10.1016/S0021-9673(01)01489-3 |
0.325 |
|
| 2002 |
Makarycheva-Mikhailova AV, Haukka M, Bokach NA, Garnovskii DA, Galanski M, Keppler BK, Pombeiro AJL, Kukushkin VY. Platinum(IV)-mediated coupling of dione monoximes and nitriles: a novel reactivity pattern of the classic oxime-based chelating ligands New Journal of Chemistry. 26: 1085-1091. DOI: 10.1039/B202947B |
0.367 |
|
| 2002 |
Nazarov AA, Hartinger CG, Arion VB, Giester G, Keppler BK. Synthesis of ferrocenylglucose phosphonite and bisphosphinite: Pd(II) and Pt(II) complexes, Pd-catalyzed allylic alkylation Tetrahedron. 58: 8489-8492. DOI: 10.1016/S0040-4020(02)01027-X |
0.338 |
|
| 2002 |
Küng A, Galanski M, Baumgartner C, Keppler BK. Reaction of (SP-4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) with 5′-GMP under simulated physiological conditions, a CZE-ESI-MS study Inorganica Chimica Acta. 339: 9-13. DOI: 10.1016/S0020-1693(02)00915-5 |
0.4 |
|
| 2002 |
Galanski M, Zimmermann W, Berger M, Baumgartner C, Giester G, Keppler BK. Carboxylation of 2-Hydroxyethyl-Substituted Tetrachloro(ethane-1,2-diamine)platinum(IV) Complexes — A New Synthetic Approach to Anticancer Platinum Compounds European Journal of Inorganic Chemistry. 2002: 417-421. DOI: 10.1002/1099-0682(20022)2002:2<417::Aid-Ejic417>3.0.Co;2-4 |
0.447 |
|
| 2001 |
Küng A, Strickmann DB, Galanski M, Keppler BK. Comparison of the binding behavior of oxaliplatin, cisplatin and analogues to 5'-GMP in the presence of sulfur-containing molecules by means of capillary electrophoresis and electrospray mass spectrometry. Journal of Inorganic Biochemistry. 86: 691-698. PMID 11583787 DOI: 10.1016/S0162-0134(01)00225-2 |
0.369 |
|
| 2001 |
Küng A, Pieper T, Keppler BK. Investigations into the interaction between tumor-inhibiting ruthenium(III) complexes and nucleotides by capillary electrophoresis Journal of Chromatography B: Biomedical Sciences and Applications. 759: 81-89. PMID 11499632 DOI: 10.1016/S0378-4347(01)00205-5 |
0.408 |
|
| 2001 |
Hann S, Zenker A, Galanski M, Bereuter T, Stingeder G, Keppler BK. HPIC-UV-ICP-SFMS study of the interaction of cisplatin with guanosine monophosphate. Fresenius Journal of Analytical Chemistry. 370: 581-586. PMID 11496990 DOI: 10.1007/S002160100740 |
0.331 |
|
| 2001 |
Zöllner P, Zenker A, Galanski M, Keppler BK, Lindner W. Reaction monitoring of platinum(II) complex--5'-guanosine monophosphate adduct formation by ion exchange liquid chromatography/electrospray ionization mass spectrometry. Journal of Mass Spectrometry : Jms. 36: 742-53. PMID 11473397 DOI: 10.1002/Jms.178 |
0.419 |
|
| 2001 |
Malina J, Novakova O, Keppler BK, Alessio E, Brabec V. Biophysical analysis of natural, double-helical DNA modified by anticancer heterocyclic complexes of ruthenium(III) in cell-free media. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 6: 435-45. PMID 11372202 DOI: 10.1007/S007750100223 |
0.339 |
|
| 2001 |
Küng A, Pieper T, Wissiack R, Rosenberg E, Keppler BK. Hydrolysis of the tumor-inhibiting ruthenium(III) complexes HIm trans-[RuCl4(im)2] and HInd trans-[RuCl4(ind)2] investigated by means of HPCE and HPLC-MS Journal of Biological Inorganic Chemistry. 6: 292-299. PMID 11315565 DOI: 10.1007/S007750000203 |
0.407 |
|
| 2001 |
Küng A, Zenker A, Galanski M, Keppler BK. Capillary electrophoretic study of carboplatin and analogues with nucleoside monophosphates, di- and trinucleotides Journal of Inorganic Biochemistry. 83: 181-186. PMID 11237257 DOI: 10.1016/S0162-0134(00)00182-3 |
0.403 |
|
| 2001 |
Pieper T, Sommer M, Galanski M, Keppler BK, Giester G. [RuCl3ind3] and [RuCl2ind4]: Two New Ruthenium Complexes derived from the Tumor-inhibiting RuIII Compound HInd (OC-6-11)-[RuCl4ind2] (ind = indazole) Zeitschrift FüR Anorganische Und Allgemeine Chemie. 627: 261-265. DOI: 10.1002/1521-3749(200102)627:2<261::Aid-Zaac261>3.0.Co;2-K |
0.378 |
|
| 2001 |
Galanski M, Zimmermann W, Baumgartner C, Keppler BK. The Intramolecular Ligand-Exchange Reaction of (SP-4-2)-Dichlorobis(2-hydroxyethylamine)platinum(II) and (OC-6-22)-Tetrachlorobis(2-hydroxyethylamine)platinum(IV), a1H and15N,1H-HMQC NMR Study European Journal of Inorganic Chemistry. 2001: 1145-1149. DOI: 10.1002/1099-0682(200105)2001:5<1145::Aid-Ejic1145>3.0.Co;2-E |
0.4 |
|
| 2000 |
Galanski M, Berger M, Keppler BK. Synthesis of (N,N'-Bis(2-Hydroxyethyl)Ethane-1,2-Diamine)Malonatoplatinum(II) and X-Ray Crystal Structure of the Cis-R,S-Isomer. Metal-Based Drugs. 7: 349-355. PMID 18475967 DOI: 10.1155/Mbd.2000.349 |
0.394 |
|
| 2000 |
Messori L, Vilchez FG, Vilaplana R, Piccioli F, Alessio E, Keppler BK. Binding of Antitumor Ruthenium(III) Complexes to Plasma Proteins. Metal-Based Drugs. 7: 335-342. PMID 18475965 DOI: 10.1155/Mbd.2000.335 |
0.378 |
|
| 2000 |
Zenker A, Galanski M, Bereuter TL, Keppler BK, Lindner W. Kinetics of binding properties of 5'-GMP with cisplatin under simulated physiological conditions by capillary electrophoresis. Journal of Chromatography B: Biomedical Sciences and Applications. 745: 211-219. PMID 10997716 DOI: 10.1016/S0378-4347(00)00096-7 |
0.314 |
|
| 2000 |
Zenker A, Galanski M, Bereuter TL, Keppler BK, Lindner W. Time-dependent interactions of platinum(II) complexes with 5'-GMP under simulated physiological conditions studies by capillary electrophoresis. Journal of Biological Inorganic Chemistry. 5: 498-504. PMID 10968621 DOI: 10.1007/S007750050010 |
0.409 |
|
| 2000 |
Galanski M, Keppler BK. Is reduction required for antitumour activity of platinum(IV) compounds? Characterisation of a platinum(IV)–nucleotide adduct [enPt(OCOCH3)3(5′-GMP)] by NMR spectroscopy and ESI-MS Inorganica Chimica Acta. 300: 783-789. DOI: 10.1016/S0020-1693(99)00613-1 |
0.452 |
|
| 1999 |
Trynda-Lemiesz L, Kozłowski H, Keppler BK. Effect of cis-, trans-diamminedichloroplatinum(II) and DBP on human serum albumin. Journal of Inorganic Biochemistry. 77: 141-146. PMID 10643655 DOI: 10.1016/S0162-0134(99)00183-X |
0.398 |
|
| 1999 |
Zenker A, Galanski M, Bereuter TL, Keppler BK, Lindner W. Capillary electrophoretic study of cisplatin interaction with nucleoside monophosphates, di- and trinucleotides Journal of Chromatography A. 852: 337-346. PMID 10480259 DOI: 10.1016/S0021-9673(99)00467-7 |
0.347 |
|
| 1999 |
Trynda-Lemiesz L, Keppler BK, KozłLowski H. Studies on the interactions between human serum albumin and imidazolium [trans-tetrachlorobis(imidazol)ruthenate(III)]. Journal of Inorganic Biochemistry. 73: 123-128. PMID 10331241 DOI: 10.1016/S0162-0134(99)00004-5 |
0.304 |
|
| 1999 |
Zimmermann W, Galanski M, Keppler BK, Giester G. Synthesis and structures of ( SP -4-2)-diiodobis(2-hydroxyethylamine)platinum(II), ( SP -4-2)-dichlorobis(2-hydroxyethylamine)platinum(II) and ( OC -6-22)-bis(2-hydroxyethylamine)tetrachloroplatinum(IV) in the crystal Inorganica Chimica Acta. 292: 127-130. DOI: 10.1016/S0020-1693(99)00175-9 |
0.376 |
|
| 1999 |
Szpunar J, Makarov A, Pieper T, Keppler BK, Łobiński R. Investigation of metallodrug–protein interactions by size-exclusion chromatography coupled with inductively coupled plasma mass spectrometry (ICP-MS) Analytica Chimica Acta. 387: 135-144. DOI: 10.1016/S0003-2670(99)00074-4 |
0.331 |
|
| 1999 |
Peti W, Pieper T, Sommer M, Keppler BK, Giester G. Synthesis of Tumor‐Inhibiting Complex Salts Containing the Anion trans‐Tetrachlorobis(indazole)ruthenate(III) and Crystal Structure of the Tetraphenylphosphonium Salt European Journal of Inorganic Chemistry. 1999: 1551-1555. DOI: 10.1002/(Sici)1099-0682(199909)1999:9<1551::Aid-Ejic1551>3.0.Co;2-7 |
0.388 |
|
| 1998 |
Kersten L, Bräunlich H, Keppler BK, Gliesing C, Wendelin M, Westphal J. Comparative nephrotoxicity of some antitumour-active platinum and ruthenium complexes in rats. Journal of Applied Toxicology. 18: 93-101. PMID 9570691 DOI: 10.1002/(Sici)1099-1263(199803/04)18:2<93::Aid-Jat472>3.0.Co;2-W |
0.36 |
|
| 1998 |
Pieper T, Keppler BK. Tumor-inhibiting ruthenium complexes -formulation and analytical characterization Analusis. 26: 84-90. DOI: 10.1051/Analusis:199826060084 |
0.346 |
|
| 1998 |
Hartmann M, Lipponer K, Keppler BK. Imidazole release from the antitumor-active ruthenium complex imidazolium trans-tetrachlorobis(imidazole) ruthenate(III) by biologically occurring nucleophiles Inorganica Chimica Acta. 267: 137-141. DOI: 10.1016/S0020-1693(97)05556-4 |
0.42 |
|
| 1997 |
Depenbrock H, Schmelcher S, Peter R, Keppler BK, Weirich G, Block T, Rastetter J, Hanauske A-. Preclinical Activity of Trans-indazolium (Tetrachlorobisindazoleruthenate(III)) (NSC 666158; IndCR; KP 1019) Against Tumour Colony-forming Units and Haematopoietic Progenitor Cells European Journal of Cancer. 33: 2404-2410. PMID 9616290 DOI: 10.1016/S0959-8049(97)00277-3 |
0.34 |
|
| 1997 |
Galanski M, Keppler BK. Carboxylation of dihydroxoplatinum(IV) complexes with acyl chlorides. Crystal structures of the trans-R,R- and trans-S,S-isomer of (OC-6-33)-bis(1-adamantanecarboxylato)-(cyclohexane-1,2-diamine)dichloroplatinum(IV) Inorganica Chimica Acta. 265: 271-274. DOI: 10.1016/S0020-1693(97)05639-9 |
0.372 |
|
| 1997 |
Einhäuser T, Galanski M, Vogel E, Keppler B. The influence of calcium ions on the DNA binding behaviour of a new platinum(II) compound linked to an amino phosphonic acid Inorganica Chimica Acta. 257: 265-268. DOI: 10.1016/S0020-1693(96)05477-1 |
0.335 |
|
| 1997 |
Dittes U, Vogel E, Keppler BK. Overview on bismuth(III) and bismuth(V) complexes with activity against Helicobacter pylori Coordination Chemistry Reviews. 163: 345-364. DOI: 10.1016/S0010-8545(97)00042-8 |
0.379 |
|
| 1997 |
Hartmann M, Robert A, Duarte V, Keppler BK, Meunier B. Synthesis of water-soluble ruthenium porphyrins as DNA cleavers and potential cytotoxic agents Journal of Biological Inorganic Chemistry. 2: 427-432. DOI: 10.1007/S007750050153 |
0.415 |
|
| 1996 |
Lipponer K, Vogel E, Keppler BK. Synthesis, Characterization and Solution Chemistry of trans-Indazoliumtetrachlorobis(Indazole)Ruthenate(III), a New Anticancer Ruthenium Complex. IR, UV, NMR, HPLC Investigations and Antitumor Activity. Crystal Structures of trans-1-Methyl-Indazoliumtetrachlorobis-(1-Methylindazole)Ruthenate(III) and its Hydrolysis Product trans-Monoaquatrichlorobis-(1-Methylindazole)-Ruthenate(III). Metal-Based Drugs. 3: 243-260. PMID 18472901 DOI: 10.1155/Mbd.1996.243 |
0.418 |
|
| 1996 |
Kratz F, Keppler BK, Hartmann M, Messori L, Berger MR. Comparison of the Antiproliferative Activity of Two Antitumour Ruthenium(III) Complexes With Their Apotransferrin and Transferrin-Bound Forms in a Human Colon Cancer Cell Line. Metal-Based Drugs. 3: 15-23. PMID 18472789 DOI: 10.1155/Mbd.1996.15 |
0.414 |
|
| 1996 |
Galanski M, Keppler BK. Carboxylation of Dihydroxoplatinum(IV) Complexes via a New Synthetic Pathway. Inorganic Chemistry. 35: 1709-1711. PMID 11666395 DOI: 10.1021/Ic9509490 |
0.381 |
|
| 1996 |
Winckler W, Pieper T, Keppler BK. Preparation Of Octaethyl-3-Amino-Pentane-1,1,5,5-Tetrakisphosphonate By Catalytic Hydrogenation Of The Corresponding 3-Nitro-Compound Phosphorus Sulfur and Silicon and the Related Elements. 112: 137-141. DOI: 10.1080/10426509608046357 |
0.316 |
|
| 1996 |
Einhäuser TJ, Galanski M, Keppler BK. Determination of platinum in protein-bound CDDP and DBP by inductively coupled plasma optical emission spectrometry and electrothermal atomic absorption spectrometry Journal of Analytical Atomic Spectrometry. 11: 747-750. DOI: 10.1039/Ja9961100747 |
0.31 |
|
| 1996 |
Hartmann M, Einhäuser TJ, Keppler BK. Two antitumour ruthenium(III) complexes showing selectivity in their binding towards poly(dG)·poly(dC) and poly(dA)·poly(dT) Chemical Communications. 1741-1742. DOI: 10.1039/Cc9960001741 |
0.342 |
|
| 1996 |
Dittes U, Keppler BK, Nuber B. Synthesis and Structure of Seven‐Coordinate Bismuth(V) Complexes with Benzenoid and Non‐Benzenoid Arene Ligands: Tri(aryl)tropolonatobismuth(V) Complexes Angewandte Chemie. 35: 67-68. DOI: 10.1002/Anie.199600671 |
0.37 |
|
| 1995 |
Diemer R, Dittes U, Nuber B, Seifried V, Opferkuch W, Keppler BK. Synthesis, Characterization and Molecular Structures of some Bismuth(III) Complexes with Thiosemicarbazones and Dithiocarbazonic Acid Methylester Derivatives with Activity against Helicobacter Pylori. Metal-Based Drugs. 2: 271-292. PMID 18472778 DOI: 10.1155/Mbd.1995.271 |
0.343 |
|
| 1995 |
Galanski M, Keppler BK. Synthesis and Characterization of New Ethylenediamine Platinum(IV) Complexes Containing Lipophilic Carboxylate Ligands. Metal-Based Drugs. 2: 57-63. PMID 18472746 DOI: 10.1155/Mbd.1995.57 |
0.441 |
|
| 1995 |
Leperre A, Millart H, Prévost A, Trenque T, Kantelip J, Keppler B. Compared effects of ruthenium red and cis [Ru(NH3)4Cl2]Cl on the isolated ischaemic-reperfused rat heart Fundamental & Clinical Pharmacology. 9: 545-553. PMID 8808175 DOI: 10.1111/J.1472-8206.1995.Tb00532.X |
0.312 |
|
| 1995 |
Hartmann M, Keppler BK. Inorganic Anticancer Agents: Their Chemistry and Antitumor Properties Comments On Inorganic Chemistry. 16: 339-372. DOI: 10.1080/02603599508035776 |
0.415 |
|
| 1995 |
Gund A, Keppler BK, Nuber B. Five-Coordinate Platinum Olefin Complexes: Synthesis, 1H NMR Investigations, and Crystal Structure of a Platinum .eta.2-Ethylene Crown Ether Complex Inorganic Chemistry. 34: 2788-2790. DOI: 10.1021/Ic00114A043 |
0.386 |
|
| 1995 |
Roulette V, Depenbrock H, Peter R, Keppler BK, Block T, Fellbaum C, Schweighart S, Rastetter J, Hanauske A-. 118 Effects of KP 1220, a new platinum compound, on colony forming units from freshly explanted human tumors in vitro European Journal of Cancer. 31. DOI: 10.1016/0959-8049(95)95373-E |
0.314 |
|
| 1995 |
Bauer RP, Depenbrock H, Peter R, Keppler BK, Fellbaum CH, Block T, Rastetter J, Hanauske A-. 117 Effects of KP 735, a new platinum-based antitumor agent on clonogenic growth of freshly explanted human tumors in vitro European Journal of Cancer. 31. DOI: 10.1016/0959-8049(95)95372-D |
0.323 |
|
| 1995 |
Dittes U, Diemer R, Lenz O, Keppler BK. New bismuth(III) complexes with derivatives of tropolones and thiosemicarbazones against the gastritis-causing bacteria helicobacter pylori Journal of Inorganic Biochemistry. 59: 215. DOI: 10.1016/0162-0134(95)97321-G |
0.349 |
|
| 1995 |
Galanski M, Keppler BK, Klenner T. Antitumor platinum compounds linked to amino phosphonic acids: Drug targeting with osteotropic platinum compounds against bone malignancies Journal of Inorganic Biochemistry. 59: 212. DOI: 10.1016/0162-0134(95)97318-K |
0.306 |
|
| 1995 |
Marx MBL, Pritzkow H, Keppler BK. Synthesis and characterization of 9,10-diethyl-2,4,6,8-tetraoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane (I) and S-9,10-dimethyl-2,4,6,8-tetraoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane (II), two compounds analogous to As(III)oxide Journal of Inorganic Biochemistry. 59: 210. DOI: 10.1016/0162-0134(95)97316-I |
0.34 |
|
| 1995 |
Chatlas J, Eldik Rv, Keppler BK. Spontaneous aquation reactions of a promising tumor inhibitor trans-imidazolium-tetrachlorobis(imidazole)ruthenium(III), trans-HIm[RuCl4(Im)2] Inorganica Chimica Acta. 233: 59-63. DOI: 10.1016/0020-1693(94)04447-4 |
0.315 |
|
| 1995 |
Galanski M, Keppler BK. Synthesis and characterization of new diam(M)ine platinum(IV) complexes containing lipophilic carboxylate ligands Journal of Cancer Research and Clinical Oncology. 121. DOI: 10.1007/Bf02572163 |
0.452 |
|
| 1995 |
Dittes U, Diemer R, Keppler BK. New tumor-inhibiting bismuth(III) complexes with derivatives of tropolones and thiosemicarbazones Journal of Cancer Research and Clinical Oncology. 121. DOI: 10.1007/Bf02572162 |
0.37 |
|
| 1995 |
Diemer R, Keppler BK, Dittes U, Nuber B, Seifried V, Opferkuch W. Preparation and Characterization of Biologically Active Bismuth(III) Tropolonato Complexes Chemische Berichte. 128: 335-342. DOI: 10.1002/Cber.19951280404 |
0.415 |
|
| 1995 |
Galanski M, Keppler BK, Nuber B. First Isolation of an Enol of a Carboxylic Acid by Complexation to an (Ethane‐1,2‐diamine)‐platinum(II) Fragment Angewandte Chemie. 34: 1103-1104. DOI: 10.1002/Anie.199511031 |
0.354 |
|
| 1995 |
Galanski M, Keppler BK, Nuber B. Erstmalige Isolierung des Enols einer Carbonsäure durch Komplexierung an eine (Ethan-1,2-diamin)platin(II)-Einheit† Angewandte Chemie. 107: 1220-1221. DOI: 10.1002/Ange.19951071021 |
0.3 |
|
| 1994 |
Keppler BK, Hartmann M. New tumor-inhibiting metal complexes. Chemistry and antitumor properties. Metal-Based Drugs. 1: 145-149. PMID 18476225 DOI: 10.1155/Mbd.1994.145 |
0.34 |
|
| 1994 |
Dhubhghaill OMN, Hagen WR, Keppler BK, Lipponer K, Sadler PJ. Aquation of the anticancer complex trans-[RuCl4(Him)2]–(Him = imidazole) Journal of the Chemical Society-Dalton Transactions. 3305-3310. DOI: 10.1039/Dt9940003305 |
0.333 |
|
| 1994 |
Comba P, Jakob H, Nuber B, Keppler BK. Solution Structures and Isomer Distributions of Bis(.beta.-diketonato) Complexes of Titanium(IV) and Cobalt(III) Inorganic Chemistry. 33: 3396-3400. DOI: 10.1021/Ic00093A031 |
0.323 |
|
| 1994 |
Bloemink MJ, Keppler BK, Zahn H, Dorenbos JP, Heetebrij RJ, Reedijk J. New Antitumor Platinum Compounds Linked to Amino Phosphonic Acids Which Lose the Phosphonate and Tertiary Amine Ligand upon Binding to Nucleic Acids Inorganic Chemistry. 33: 1127-1132. DOI: 10.1021/Ic00084A026 |
0.424 |
|
| 1994 |
Gund A, Keppler BK. Structure of an Antineoplastic Platinum Complex with a Bipyridyl–Crown Ether Angewandte Chemie. 33: 186-188. DOI: 10.1002/Anie.199401861 |
0.36 |
|
| 1993 |
Lopez-Garzon R, Gutierrez-Valero MD, Godino-Salido ML, Keppler BK, Nuber B. SPECTROSCOPIC STUDIES OF METAL-PYRIMIDINE COMPLEXES. CRYSTAL STRUCTURES OF 4,6-DIMETHYL-2-THIOPYRIMIDINE COMPLEXES WITH Zn(II) AND Cd(II) Journal of Coordination Chemistry. 30: 111-123. DOI: 10.1080/00958979308024663 |
0.333 |
|
| 1993 |
Kratz F, Messori L, Keppler BK. Interaction of the antitumour ruthenium(III) complex trans-indazolium[tetrachlorobisindazoleruthenate(III)] with apotransferrin Journal of Inorganic Biochemistry. 51: 435. DOI: 10.1016/0162-0134(93)85464-J |
0.378 |
|
| 1993 |
Einhäuser TJ, Keppler BK. ICP-AES measurement of DNA metal binding of new tumor-inhibiting titanium and ruthenium compounds Journal of Inorganic Biochemistry. 51: 434. DOI: 10.1016/0162-0134(93)85463-I |
0.316 |
|
| 1993 |
Bloemink MJ, Dorenbos JP, Keppler BK, Reedijk J, Zahn H. Understanding the molecular mechanism of platinum antitumor complexes containing aminophosphonic ligands. Journal of Inorganic Biochemistry. 51: 419. DOI: 10.1016/0162-0134(93)85448-H |
0.383 |
|
| 1992 |
Galeano A, Berger MR, Keppler BK. Activity of two platinum-linked phosphonic acids against autochthonous rat colorectal cancer as well as in two human colon-cancer cell lines. Cancer Chemotherapy and Pharmacology. 30: 131-138. PMID 1600593 DOI: 10.1007/Bf00686405 |
0.347 |
|
| 1992 |
Seelig MH, Berger MR, Keppler BK. Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats. Journal of Cancer Research and Clinical Oncology. 118: 195-200. PMID 1548284 DOI: 10.1007/Bf01410134 |
0.3 |
|
| 1992 |
Kratz F, Nuber B, Weiß J, Keppler BK. Synthesis and characterization of potential antitumour and antiviral gallium(III) complexes of N-heterocycles Polyhedron. 11: 487-498. DOI: 10.1016/S0277-5387(00)83206-4 |
0.412 |
|
| 1991 |
Zeller WJ, Frühauf S, Chen G, Keppler BK, Frei E, Kaufmann M. Chemoresistance in rat ovarian tumours. European Journal of Cancer and Clinical Oncology. 27: 62-67. PMID 1826445 DOI: 10.1016/0277-5379(91)90063-J |
0.334 |
|
| 1990 |
Keppler BK, Berger MR, Heim ME. New tumor-inhibiting metal complexes. Cancer Treatment Reviews. 17: 261-277. PMID 2272042 DOI: 10.1016/0305-7372(90)90057-M |
0.328 |
|
| 1990 |
Klenner T, Valenzuela-Paz P, Keppler BK, Scherf HR. Sensitivity of rodent osteosarcoma clones to platinum-containing phosphonic acid complexes in vitro. Journal of Cancer Research and Clinical Oncology. 116: 453-458. PMID 2229134 DOI: 10.1007/Bf01612993 |
0.371 |
|
| 1990 |
Keppler BK, Berger MR, Klenner T, Heim ME. Metal Complexes as Antitumour Agents Advances in Drug Research. 19: 243-310. DOI: 10.1016/B978-0-12-013319-2.50008-5 |
0.326 |
|
| 1987 |
Bischoff H, Berger MR, Keppler BK, Schmähl D. Efficacy of β-diketonato complexes of titanium, zirconium, and hafnium against chemically induced autochthonous colonic tumors in rats Journal of Cancer Research and Clinical Oncology. 113: 446-450. PMID 3624300 DOI: 10.1007/Bf00390038 |
0.327 |
|
| 1986 |
Keppler BK, Rupp W. Antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III). A representative of a new class of inorganic antitumor agents. Journal of Cancer Research and Clinical Oncology. 111: 166-168. PMID 3700462 DOI: 10.1007/Bf00400758 |
0.32 |
|
| 1983 |
Keller HJ, Keppler B, Schmähl D. Antitumor activity of cis-dihalogenobis(1-phenyl-1,3-butanedionato)titanium (IV) compounds. A new class of antineoplastic agents. Journal of Cancer Research and Clinical Oncology. 105: 109-110. PMID 6682104 DOI: 10.1007/Bf00391842 |
0.338 |
|
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