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Christopher H. Switzer - Publications

Affiliations: 
1999-2004 Chemistry University of California, Los Angeles, Los Angeles, CA 
 2023- Molecular and Cell Biology University of Leicester, Leicester, England, United Kingdom 
Area:
Biological chemistry; bioinorganic chemistry; cell biology
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Switzer CH. Non-canonical nitric oxide signalling and DNA hypomethylation: inflammation induced epigenetic alterations and potential drug targets. British Journal of Pharmacology. PMID 38116806 DOI: 10.1111/bph.16302  0.66
2023 Switzer CH. How super is supersulfide?: Reconsidering persulfide reactivity in cellular biology. Redox Biology. 67: 102899. PMID 37748320 DOI: 10.1016/j.redox.2023.102899  0.652
2023 Switzer CH, Kasamatsu S, Ihara H, Eaton P. SOD1 is an essential HS detoxifying enzyme. Proceedings of the National Academy of Sciences of the United States of America. 120: e2205044120. PMID 36630448 DOI: 10.1073/pnas.2205044120  0.658
2022 Switzer CH, Fukuto JM. The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species. Redox Biology. 57: 102486. PMID 36201912 DOI: 10.1016/j.redox.2022.102486  0.731
2022 Switzer CH, Cho HJ, Eykyn TR, Lavender P, Eaton P. NOS2 and -nitrosothiol signaling induces DNA hypomethylation and LINE-1 retrotransposon expression. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200022119. PMID 35584114 DOI: 10.1073/pnas.2200022119  0.669
2021 Switzer CH, Guttzeit S, Eykyn TR, Eaton P. Cysteine trisulfide oxidizes protein thiols and induces electrophilic stress in human cells. Redox Biology. 47: 102155. PMID 34607161 DOI: 10.1016/j.redox.2021.102155  0.655
2020 Cho HJ, Switzer CH, Kamynina A, Charles R, Rudyk O, Ng T, Burgoyne JR, Eaton P. Complex interrelationships between nitro-alkene-dependent inhibition of soluble epoxide hydrolase, inflammation and tumor growth. Redox Biology. 29: 101405. PMID 31926628 DOI: 10.1016/j.redox.2019.101405  0.623
2019 Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P, Burgoyne JR. Response by Prysyazhna et al to Letter Regarding Article, "Blood Pressure-Lowering by the Antioxidant Resveratrol Is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase". Circulation. 140: e810-e811. PMID 31765257 DOI: 10.1161/CIRCULATIONAHA.119.043869  0.615
2019 Prysyazhna O, Wolhuter K, Switzer C, Santos C, Yang X, Lynham S, Shah AM, Eaton P, Burgoyne JR. Blood Pressure-Lowering by the Antioxidant Resveratrol is Counterintuitively Mediated by Oxidation of cGMP-Dependent Protein Kinase. Circulation. PMID 31116951 DOI: 10.1161/CIRCULATIONAHA.118.037398  0.648
2019 Chemama M, Switzer C. Flexible Nucleic Acids (FNAs) as Informational Molecules: Enzymatic Polymerization of fNTPs on DNA Templates and Nonenzymatic Oligomerization of RNA on FNA Templates. Methods in Molecular Biology (Clifton, N.J.). 1973: 213-236. PMID 31016705 DOI: 10.1007/978-1-4939-9216-4_14  0.618
2018 Hoshika S, Singh I, Switzer C, Molt RW, Leal NA, Kim MJ, Kim MS, Kim HJ, Georgiadis MM, Benner SA. "Skinny" and "Fat" DNA: Two New Double Helices. Journal of the American Chemical Society. PMID 30148365 DOI: 10.1021/Jacs.8B05042  0.631
2018 Mei H, Liao JY, Jimenez RM, Wang Y, Bala S, McCloskey C, Switzer C, Chaput JC. Synthesis and Evolution of a TNA Aptamer Bearing 7-Deaza-7-Substituted Guanosine Residues. Journal of the American Chemical Society. PMID 29667819 DOI: 10.1021/Jacs.7B13031  0.639
2018 Wolhuter K, Whitwell HJ, Switzer CH, Burgoyne JR, Timms JF, Eaton P. Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation. Molecular Cell. PMID 29358077 DOI: 10.1016/j.molcel.2017.12.019  0.631
2016 Lee DK, Switzer C. Polymerase recognition of 2-thio-iso-guanine·5-methyl-4-pyrimidinone (iGs·P)-A new DD/AA base pair. Bioorganic & Medicinal Chemistry Letters. PMID 26821822 DOI: 10.1016/J.Bmcl.2016.01.041  0.617
2015 Scharf C, Virgo N, Cleaves HJ, Aono M, Aubert-Kato N, Aydinoglu A, Barahona A, Barge LM, Benner SA, Biehl M, Brasser R, Butch CJ, Chandru K, Cronin L, Danielache S, ... ... Switzer C, et al. A Strategy for Origins of Life Research. Astrobiology. 15: 1031-42. PMID 26684503 DOI: 10.1089/Ast.2015.1113  0.575
2015 Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD, Glynn S, Fukuto JM, Wink DA, Miranda KM. Signaling and stress: The redox landscape in NOS2 biology. Free Radical Biology & Medicine. 87: 204-225. PMID 26117324 DOI: 10.1016/J.Freeradbiomed.2015.06.002  0.719
2015 Lee D, Switzer C. DNA duplex stability of the thio-iso-guanine•methyl-iso-Cytosine base pair. Nucleosides, Nucleotides & Nucleic Acids. 34: 424-32. PMID 25965331 DOI: 10.1080/15257770.2015.1013127  0.631
2014 Cheng RY, Basudhar D, Ridnour LA, Heinecke JL, Kesarwala AH, Glynn S, Switzer CH, Ambs S, Miranda KM, Wink DA. Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 43: 17-28. PMID 25153034 DOI: 10.1016/J.Niox.2014.08.003  0.66
2014 Kim EK, Switzer C. Bis(6-carboxypurine)-Cu2+: a possibly primitive metal-mediated nucleobase pair. Organic Letters. 16: 4059-61. PMID 25068600 DOI: 10.1021/Ol5018728  0.623
2014 Heinecke JL, Ridnour LA, Cheng RY, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP, Young HA, Ambs S, Wink DA. Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 111: 6323-8. PMID 24733928 DOI: 10.1073/Pnas.1401799111  0.653
2013 Kim EK, Switzer C. Polymerase recognition of a Watson-Crick-like metal-mediated base pair: purine-2,6-dicarboxylate⋅copper(II)⋅ pyridine. Chembiochem : a European Journal of Chemical Biology. 14: 2403-7. PMID 24194348 DOI: 10.1002/Cbic.201300634  0.613
2013 Heinrich TA, da Silva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM. Biological nitric oxide signalling: chemistry and terminology. British Journal of Pharmacology. 169: 1417-29. PMID 23617570 DOI: 10.1111/Bph.12217  0.729
2013 Ridnour LA, Cheng RY, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G, Wink DA. Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 1340-6. PMID 23271799 DOI: 10.1158/1078-0432.Ccr-12-0408  0.641
2013 Switzer CH, Miller TW, Farmer PJ, Fukuto JM. Synthesis and characterization of lithium oxonitrate (LiNO). Journal of Inorganic Biochemistry. 118: 128-33. PMID 23107606 DOI: 10.1016/J.Jinorgbio.2012.09.022  0.726
2012 Switzer CH, Ridnour LA, Cheng R, Heinecke J, Burke A, Glynn S, Ambs S, Wink DA. S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer. Forum On Immunopathological Diseases and Therapeutics. 3: 117-124. PMID 23543871 DOI: 10.1615/Forumimmundisther.2012006108  0.648
2012 Switzer CH, Cheng RY, Ridnour LA, Glynn SA, Ambs S, Wink DA. Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer. Breast Cancer Research : Bcr. 14: R125. PMID 22971289 DOI: 10.1186/Bcr3319  0.644
2012 Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RY, Heinecke JL, Brueggemann E, Hines HB, Khanna C, Glynn SA, Ambs S, et al. Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. Plos One. 7: e44081. PMID 22957045 DOI: 10.1371/Journal.Pone.0044081  0.646
2012 Switzer CH, Glynn SA, Cheng RY, Ridnour LA, Green JE, Ambs S, Wink DA. S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer. Molecular Cancer Research : McR. 10: 1203-15. PMID 22878588 DOI: 10.1158/1541-7786.Mcr-12-0124  0.65
2012 Kang M, Heuberger B, Chaput JC, Switzer C, Feigon J. Solution structure of a parallel-stranded oligoisoguanine DNA pentaplex formed by d(T(iG)4T) in the presence of Cs+ ions Angewandte Chemie - International Edition. 51: 7952-7955. PMID 22767484 DOI: 10.1002/Anie.201203459  0.596
2012 Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA. Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer. Cancer Research. 72: 2394-404. PMID 22436383 DOI: 10.1158/0008-5472.Can-11-3115  0.64
2011 Switzer CH, Glynn SA, Ridnour LA, Cheng RY, Vitek MP, Ambs S, Wink DA. Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. Trends in Pharmacological Sciences. 32: 644-51. PMID 21893353 DOI: 10.1016/J.Tips.2011.07.001  0.651
2011 Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L, Cheng R, Glynn SA, Paolocci N, Fukuto JM, Miranda KM, Wink DA. The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Antioxidants & Redox Signaling. 14: 1659-74. PMID 21235346 DOI: 10.1089/Ars.2010.3841  0.728
2011 Wink DA, Hines HB, Cheng RY, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA. Nitric oxide and redox mechanisms in the immune response. Journal of Leukocyte Biology. 89: 873-91. PMID 21233414 DOI: 10.1189/Jlb.1010550  0.641
2010 Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH, Hudson RS, Wink DA, Lee DH, Stephens RM, Ambs S. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. The Journal of Clinical Investigation. 120: 3843-54. PMID 20978357 DOI: 10.1172/Jci42059  0.646
2010 Zhang S, Switzer C, Chaput JC. The resurgence of acyclic nucleic acids Chemistry and Biodiversity. 7: 245-258. PMID 20151377 DOI: 10.1002/Cbdv.200900281  0.607
2010 Kim EK, Switzer C. Nonenzymatic oligomerization of activated nucleotides on hairpin templates. Current Protocols in Nucleic Acid Chemistry. Unit3.18. PMID 20013784 DOI: 10.1002/0471142700.Nc0318S39  0.631
2010 Switzer C. A missing prebiotic link: discovery of a plausible synthesis of pyrimidine nucleotides. Chembiochem : a European Journal of Chemical Biology. 10: 2591-3. PMID 19746388 DOI: 10.1002/Cbic.200900516  0.608
2010 Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA. Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. Lung Cancer (Amsterdam, Netherlands). 68: 154-60. PMID 19628293 DOI: 10.1016/J.Lungcan.2009.06.012  0.606
2009 Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S, Thomas DD, Miranda KM, Fukuto JM, Wink DA. Comparing the chemical biology of NO and HNO. Archives of Pharmacal Research. 32: 1139-53. PMID 19727606 DOI: 10.1007/S12272-009-1805-X  0.727
2009 Switzer CH, Flores-Santana W, Mancardi D, Donzelli S, Basudhar D, Ridnour LA, Miranda KM, Fukuto JM, Paolocci N, Wink DA. The emergence of nitroxyl (HNO) as a pharmacological agent. Biochimica Et Biophysica Acta. 1787: 835-40. PMID 19426703 DOI: 10.1016/J.Bbabio.2009.04.015  0.735
2009 Nallagatla SR, Heuberger B, Haque A, Switzer C. Combinatorial synthesis of thrombin-binding aptamers containing iso-guanine. Journal of Combinatorial Chemistry. 11: 364-9. PMID 19243167 DOI: 10.1021/Cc800178M  0.598
2008 Heuberger BD, Switzer C. An alternative nucleobase code: characterization of purine-purine DNA double helices bearing guanine-isoguanine and diaminopurine 7-deaza-xanthine base pairs. Chembiochem : a European Journal of Chemical Biology. 9: 2779-83. PMID 18985646 DOI: 10.1002/Cbic.200800450  0.622
2008 Donzelli S, Espey MG, Flores-Santana W, Switzer CH, Yeh GC, Huang J, Stuehr DJ, King SB, Miranda KM, Wink DA. Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. Free Radical Biology & Medicine. 45: 578-84. PMID 18503778 DOI: 10.1016/J.Freeradbiomed.2008.04.036  0.655
2008 Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA. Molecular mechanisms for discrete nitric oxide levels in cancer. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 19: 73-6. PMID 18472020 DOI: 10.1016/J.Niox.2008.04.006  0.681
2008 Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C, Paolocci N, Ambs S, Colton CA, Harris CC, Roberts DD, Wink DA. The chemical biology of nitric oxide: implications in cellular signaling. Free Radical Biology & Medicine. 45: 18-31. PMID 18439435 DOI: 10.1016/J.Freeradbiomed.2008.03.020  0.67
2008 Heuberger BD, Shin D, Switzer C. Two Watson-Crick-like metallo base-pairs. Organic Letters. 10: 1091-4. PMID 18302394 DOI: 10.1021/Ol703029D  0.612
2008 Heuberger BD, Switzer C. A pre-RNA candidate revisited: both enantiomers of flexible nucleoside triphosphates are DNA polymerase substrates. Journal of the American Chemical Society. 130: 412-3. PMID 18095688 DOI: 10.1021/Ja0770680  0.627
2007 Shin D, Switzer C. A metallo base-pair incorporating a terpyridyl-like motif: bipyridyl-pyrimidinone.Ag(I).4-pyridine. Chemical Communications (Cambridge, England). 4401-3. PMID 17957300 DOI: 10.1039/B709291A  0.607
2007 Isenberg JS, Jia Y, Fukuyama J, Switzer CH, Wink DA, Roberts DD. Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. The Journal of Biological Chemistry. 282: 15404-15. PMID 17416590 DOI: 10.1074/Jbc.M701638200  0.619
2006 Heuberger BD, Switzer C. Nonenzymatic oligomerization of RNA by TNA templates. Organic Letters. 8: 5809-11. PMID 17134278 DOI: 10.1021/Ol062368S  0.6
2006 Donzelli S, Switzer CH, Thomas DD, Ridnour LA, Espey MG, Isenberg JS, Tocchetti CG, King SB, Lazzarino G, Miranda KM, Roberts DD, Feelisch M, Wink DA. The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling. Antioxidants & Redox Signaling. 8: 1363-71. PMID 16910783 DOI: 10.1089/Ars.2006.8.1363  0.666
2005 Fukuto JM, Switzer CH, Miranda KM, Wink DA. Nitroxyl (HNO): chemistry, biochemistry, and pharmacology. Annual Review of Pharmacology and Toxicology. 45: 335-55. PMID 15822180 DOI: 10.1146/Annurev.Pharmtox.45.120403.095959  0.72
2005 Switzer C, Shin D. A pyrimidine-like nickel(II) DNA base pair. Chemical Communications (Cambridge, England). 1342-4. PMID 15742072 DOI: 10.1039/B415426F  0.631
2005 Switzer C, Sinha S, Kim PH, Heuberger BD. A purine-like nickel(II) base pair for DNA. Angewandte Chemie (International Ed. in English). 44: 1529-32. PMID 15678435 DOI: 10.1002/Anie.200462047  0.624
2004 Sinha S, Kim PH, Switzer C. 2',5'-linked DNA is a template for polymerase-directed DNA synthesis. Journal of the American Chemical Society. 126: 40-1. PMID 14709049 DOI: 10.1021/Ja034986Z  0.652
2002 Bartberger MD, Liu W, Ford E, Miranda KM, Switzer C, Fukuto JM, Farmer PJ, Wink DA, Houk KN. The reduction potential of nitric oxide (NO) and its importance to NO biochemistry. Proceedings of the National Academy of Sciences of the United States of America. 99: 10958-63. PMID 12177417 DOI: 10.1073/Pnas.162095599  0.715
2002 Chaput JC, Sinha S, Switzer C. 5-propynyluracil.diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA. Chemical Communications (Cambridge, England). 1568-9. PMID 12170785 DOI: 10.1039/B204535D  0.633
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