Amy E. Fraley - Publications

Affiliations: 
Eidgenössische Technische Hochschule Zürich, Zürich, ZH, Switzerland 
Area:
natural products, biosynthesis, medicinal chemistry, biocatalysis

14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Padhi C, Field CM, Forneris CC, Olszewski D, Fraley AE, Sandu I, Scott TA, Farnung J, Ruscheweyh HJ, Narayan Panda A, Oxenius A, Greber UF, Bode JW, Sunagawa S, Raina V, et al. Metagenomic study of lake microbial mats reveals protease-inhibiting antiviral peptides from a core microbiome member. Proceedings of the National Academy of Sciences of the United States of America. 121: e2409026121. PMID 39585984 DOI: 10.1073/pnas.2409026121  0.318
2023 Minas HA, François RMM, Hemmerling F, Fraley AE, Dieterich CL, Rüdisser SH, Meoded RA, Collin S, Weissman KJ, Gruez A, Piel J. Modular oxime formation by a trans-AT polyketide synthase. Angewandte Chemie (International Ed. in English). e202304481. PMID 37216334 DOI: 10.1002/anie.202304481  0.375
2023 Fraley AE, Dell M, Schmalhofer M, Meoded RA, Bergande C, Groll M, Piel J. Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation. Structure (London, England : 1993). 31: 565-572.e4. PMID 36917986 DOI: 10.1016/j.str.2023.02.010  0.354
2022 Hemmerling F, Meoded RA, Fraley A, Minas H, Dieterich C, Rust M, Ueoka R, Jensen K, Helfrich E, Bergande C, Biedermann M, Magnus N, Piechulla B, Piel J. Modular Halogenation, α-Hydroxylation, and Acylation by a Remarkably Versatile Polyketide Synthase. Angewandte Chemie (International Ed. in English). PMID 35020279 DOI: 10.1002/anie.202116614  0.346
2020 Ye Y, Du L, Zhang X, Newmister SA, McCauley M, Alegre-Requena JV, Zhang W, Mu S, Minami A, Fraley AE, Adrover-Castellano ML, Carney NA, Shende VV, Qi F, Oikawa H, et al. Fungal-derived brevianamide assembly by a stereoselective semipinacolase. Nature Catalysis. 3: 497-506. PMID 32923978 DOI: 10.1038/s41929-020-0454-9  0.675
2020 Fraley AE, Tran HT, Kelly SP, Newmister SA, Tripathi A, Kato H, Tsukamoto S, Du L, Li S, Williams RM, Sherman DH. Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides. Chembiochem : a European Journal of Chemical Biology. PMID 32246875 DOI: 10.1002/Cbic.202000004  0.651
2020 Fraley AE, Sherman DH. Enzyme evolution in fungal indole alkaloid biosynthesis. The Febs Journal. PMID 32118354 DOI: 10.1111/Febs.15270  0.607
2020 Fraley A, Caddell Haatveit K, Ye Y, Kelly SP, Newmister SA, Yu F, Williams RM, Smith JL, Houk KN, Sherman DH. Molecular basis for spirocycle formation in the paraherquamide biosynthetic pathway. Journal of the American Chemical Society. PMID 31904957 DOI: 10.2210/Pdb6Pvi/Pdb  0.677
2019 Dan Q, Newmister SA, Klas KR, Fraley AE, McAfoos TJ, Somoza AD, Sunderhaus JD, Ye Y, Shende VV, Yu F, Sanders JN, Brown WC, Zhao L, Paton RS, Houk KN, et al. Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels-Alderase. Nature Chemistry. PMID 31548667 DOI: 10.1038/S41557-019-0326-6  0.674
2019 Beyett TS, Fraley AE, Labudde E, Patra D, Coleman RC, Eguchi A, Glukhova A, Chen Q, Williams RM, Koch WJ, Sherman DH, Tesmer JJG. Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe. Proceedings of the National Academy of Sciences of the United States of America. PMID 31337679 DOI: 10.1073/Pnas.1818547116  0.419
2018 Skiba MA, Maloney FP, Dan Q, Fraley AE, Aldrich CC, Smith JL, Brown WC. PKS-NRPS Enzymology and Structural Biology: Considerations in Protein Production. Methods in Enzymology. 604: 45-88. PMID 29779664 DOI: 10.1016/Bs.Mie.2018.01.035  0.643
2018 Fraley AE, Sherman DH. Halogenase engineering and its utility in medicinal chemistry. Bioorganic & Medicinal Chemistry Letters. PMID 29731363 DOI: 10.1016/J.Bmcl.2018.04.066  0.504
2018 Klas KR, Kato H, Frisvad JC, Yu F, Newmister SA, Fraley AE, Sherman DH, Tsukamoto S, Williams RM. Structural and stereochemical diversity in prenylated indole alkaloids containing the bicyclo[2.2.2]diazaoctane ring system from marine and terrestrial fungi. Natural Product Reports. PMID 29632911 DOI: 10.1039/C7Np00042A  0.589
2017 Fraley AE, Garcia-Borràs M, Tripathi A, Khare D, Mercado-Marin EV, Tran H, Dan Q, Webb G, Watts K, Crews P, Sarpong R, Williams RM, Smith JL, Houk KN, Sherman DH. Function and structure of MalA/MalA', iterative halogenases for late-stage C-H functionalization of indole alkaloids. Journal of the American Chemical Society. PMID 28777910 DOI: 10.1021/Jacs.7B06773  0.666
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