Tsuneya Ikezu - Publications

Affiliations: 
Neuroscience GMS Boston University, Boston, MA, United States 
Area:
Neuroscience Biology, Molecular Biology, Pharmacy

121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yukawa K, Yamamoto-Mcguire S, Cafaro L, Hong C, Kamme F, Ikezu T, Ikezu S. Antisense oligonucleotide-based targeting of Tau-tubulin kinase 1 prevents hippocampal accumulation of phosphorylated tau in PS19 tauopathy mice. Acta Neuropathologica Communications. 11: 166. PMID 37853497 DOI: 10.1186/s40478-023-01661-3  0.353
2023 Yin Z, Rosenzweig N, Kleemann KL, Zhang X, Brandão W, Margeta MA, Schroeder C, Sivanathan KN, Silveira S, Gauthier C, Mallah D, Pitts KM, Durao A, Herron S, Shorey H, ... ... Ikezu T, et al. APOE4 impairs the microglial response in Alzheimer's disease by inducing TGFβ-mediated checkpoints. Nature Immunology. PMID 37749326 DOI: 10.1038/s41590-023-01627-6  0.346
2023 Iguchi A, Takatori S, Kimura S, Muneto H, Wang K, Etani H, Ito G, Sato H, Hori Y, Sasaki J, Saito T, Saido TC, Ikezu T, Takai T, Sasaki T, et al. INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model. Iscience. 26: 106375. PMID 37035000 DOI: 10.1016/j.isci.2023.106375  0.347
2022 Yeh H, Woodbury ME, Ingraham Dixie KL, Ikezu T, Ikezu S. Microglial WNT5A supports dendritic spines maturation and neuronal firing. Brain, Behavior, and Immunity. 107: 403-413. PMID 36395958 DOI: 10.1016/j.bbi.2022.11.003  0.783
2022 You Y, Hersh SW, Aslebagh R, Shaffer SA, Ikezu S, Mez J, Lunetta KL, Logue MW, Farrer LA, Ikezu T. Alzheimer's disease associated AKAP9 I2558M mutation alters posttranslational modification and interactome of tau and cellular functions in CRISPR-edited human neuronal cells. Aging Cell. e13617. PMID 35567427 DOI: 10.1111/acel.13617  0.375
2022 You Y, Muraoka S, Jedrychowski MP, Hu J, McQuade AK, Young-Pearse T, Aslebagh R, Shaffer SA, Gygi SP, Blurton-Jones M, Poon WW, Ikezu T. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain. Journal of Extracellular Vesicles. 11: e12183. PMID 35029059 DOI: 10.1002/jev2.12183  0.343
2021 Muraoka S, Lin W, Takamatsu-Yukawa K, Hu J, Ikezu S, DeTure MA, Dickson DW, Emili A, Ikezu T. Enrichment of Phosphorylated Tau (Thr181) and Functionally Interacting Molecules in Chronic Traumatic Encephalopathy Brain-derived Extracellular Vesicles. Aging and Disease. 12: 1376-1388. PMID 34527416 DOI: 10.14336/AD.2020.1007  0.326
2021 Muraoka S, DeLeo AM, Yang Z, Tatebe H, Yukawa-Takamatsu K, Ikezu S, Tokuda T, Issadore D, Stern RA, Ikezu T. Proteomic Profiling of Extracellular Vesicles Separated from Plasma of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Aging and Disease. 12: 1363-1375. PMID 34527415 DOI: 10.14336/AD.2020.0908  0.784
2021 Panitch R, Hu J, Chung J, Zhu C, Meng G, Xia W, Bennett DA, Lunetta KL, Ikezu T, Au R, Stein TD, Farrer LA, Jun GR. Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. Molecular Psychiatry. PMID 34480088 DOI: 10.1038/s41380-021-01266-z  0.328
2021 Podvin S, Jones A, Liu Q, Aulston B, Mosier C, Ames J, Winston C, Lietz CB, Jiang Z, O'Donoghue AJ, Ikezu T, Rissman RA, Yuan SH, Hook V. Mutant Presenilin 1 Dysregulates Exosomal Proteome Cargo Produced by Human-Induced Pluripotent Stem Cell Neurons. Acs Omega. 6: 13033-13056. PMID 34056454 DOI: 10.1021/acsomega.1c00660  0.351
2021 Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular Neurodegeneration. 16: 24. PMID 33853665 DOI: 10.1186/s13024-021-00447-2  0.808
2021 Clayton K, Delpech JC, Herron S, Iwahara N, Ericsson M, Saito T, Saido TC, Ikezu S, Ikezu T. Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model. Molecular Neurodegeneration. 16: 18. PMID 33752701 DOI: 10.1186/s13024-021-00440-9  0.843
2021 Muraoka S, Jedrychowski MP, Iwahara N, Abdullah M, Onos KD, Keezer KJ, Hu J, Ikezu S, Howell GR, Gygi SP, Ikezu T. Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. Journal of Proteome Research. PMID 33534581 DOI: 10.1021/acs.jproteome.0c00934  0.382
2020 Podvin S, Jones A, Liu Q, Aulston B, Ransom L, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman RA, Yuan S, Hook V. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Molecular & Cellular Proteomics : McP. 19: 1017-1034. PMID 33451707 DOI: 10.1074/mcp.RA120.002079  0.373
2020 Ruan Z, Pathak D, Venkatesan Kalavai S, Yoshii-Kitahara A, Muraoka S, Bhatt N, Takamatsu-Yukawa K, Hu J, Wang Y, Hersh S, Ericsson M, Gorantla S, Gendelman HE, Kayed R, Ikezu S, ... ... Ikezu T, et al. Alzheimer's disease brain-derived extracellular vesicles spread tau pathology in interneurons. Brain : a Journal of Neurology. PMID 33246331 DOI: 10.1093/brain/awaa376  0.825
2020 Muraoka S, Jedrychowski MP, Yanamandra K, Ikezu S, Gygi SP, Ikezu T. Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. Cells. 9. PMID 32854315 DOI: 10.3390/Cells9091959  0.431
2020 Ruan Z, Delpech JC, Venkatesan Kalavai S, Van Enoo AA, Hu J, Ikezu S, Ikezu T. P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice. Molecular Neurodegeneration. 15: 47. PMID 32811520 DOI: 10.1186/S13024-020-00396-2  0.465
2020 Muraoka S, DeLeo AM, Sethi MK, Yukawa-Takamatsu K, Yang Z, Ko J, Hogan JD, Ruan Z, You Y, Wang Y, Medalla M, Ikezu S, Chen M, Xia W, Gorantla S, ... ... Ikezu T, et al. Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32301581 DOI: 10.1002/Alz.12089  0.825
2020 Podvin S, Jones A, Liu Q, Aulston B, Ransom LS, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman R, Yuan S, Hook V. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-Induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Molecular & Cellular Proteomics : McP. PMID 32295833 DOI: 10.1074/Mcp.Ra120.002079  0.475
2020 Ikezu S, Yeh H, Delpech JC, Woodbury ME, Van Enoo AA, Ruan Z, Sivakumaran S, You Y, Holland C, Guillamon-Vivancos T, Yoshii-Kitahara A, Botros MB, Madore C, Chao PH, Desani A, ... ... Ikezu T, et al. Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities. Molecular Psychiatry. PMID 32071385 DOI: 10.1038/S41380-020-0671-2  0.769
2020 Ikezu S, Ingraham Dixie KL, Koro L, Watanabe T, Kaibuchi K, Ikezu T. Tau-tubulin kinase 1 and amyloid-β peptide induce phosphorylation of collapsin response mediator protein-2 and enhance neurite degeneration in Alzheimer disease mouse models. Acta Neuropathologica Communications. 8: 12. PMID 32019603 DOI: 10.1186/S40478-020-0890-4  0.499
2020 You Y, Borgmann K, Edara VV, Stacy S, Ghorpade A, Ikezu T. Activated human astrocyte-derived extracellular vesicles modulate neuronal uptake, differentiation and firing. Journal of Extracellular Vesicles. 9: 1706801. PMID 32002171 DOI: 10.1080/20013078.2019.1706801  0.347
2019 Ruan Z, Ikezu T. Tau Secretion. Advances in Experimental Medicine and Biology. 1184: 123-134. PMID 32096034 DOI: 10.1007/978-981-32-9358-8_11  0.346
2019 You Y, Botros MB, Enoo AV, Bockmiller A, Herron S, Delpech JC, Ikezu T. Cre-inducible Adeno Associated Virus-mediated Expression of P301L Mutant Tau Causes Motor Deficits and Neuronal Degeneration in the Substantia Nigra. Neuroscience. PMID 31689387 DOI: 10.1016/J.Neuroscience.2019.10.001  0.802
2019 Muraoka S, Jedrychowski MP, Tatebe H, DeLeo AM, Ikezu S, Tokuda T, Gygi SP, Stern RA, Ikezu T. Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Frontiers in Neuroscience. 13: 1059. PMID 31649498 DOI: 10.3389/Fnins.2019.01059  0.824
2019 You Y, Ikezu T. Emerging roles of extracellular vesicles in neurodegenerative disorders. Neurobiology of Disease. 104512. PMID 31229685 DOI: 10.1016/J.Nbd.2019.104512  0.337
2019 Luengo E, Buendia I, Fernández-Mendívil C, Trigo-Alonso P, Negredo P, Michalska P, Hernández-García B, Sánchez-Ramos C, Bernal JA, Ikezu T, León R, López MG. Pharmacological doses of melatonin impedes cognitive decline in tau-related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux. Journal of Pineal Research. e12578. PMID 30943316 DOI: 10.1111/Jpi.12578  0.357
2019 Delpech JC, Herron S, Botros MB, Ikezu T. Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease. Trends in Neurosciences. PMID 30926143 DOI: 10.1016/J.Tins.2019.02.007  0.367
2019 Muraoka S, DeLeo AM, Sethi MK, Hogan JD, Yang Z, Ruan Z, You Y, Yukawa K, Kalava SV, Ikezu S, Ko J, Zaia J, Issadore D, Gorantla S, Gendelman HE, ... Ikezu T, et al. IDENTIFICATION AND BIOLOGICAL CHARACTERIZATION OF EXTRACELLULAR VESICLE PROTEINS FOR PROPAGATION AND SPREAD OF TAU Alzheimer's & Dementia. 15: P192. DOI: 10.1016/J.Jalz.2019.06.4520  0.796
2019 Ruan Z, Delpech JC, Mina B, Van Enoo A, Wang K, Ikezu S, Ikezu T. P4-149: P2RX7 INHIBITOR SUPPRESSES EXOSOME SECRETION, DELAYS PROTEOPATHIC TAU ACCUMULATION AND MEMORY IMPAIRMENT IN PS19 P301S TAU MICE Alzheimer's & Dementia. 15: P1331-P1332. DOI: 10.1016/J.Jalz.2019.06.3810  0.353
2019 Muraoka S, Jedrychowski MP, Ikezu S, Gygi S, Ikezu T. P3-089: PROTEOMIC PROFILING OF EXTRACELLULAR VESICLES DERIVED FROM CEREBROSPINAL FLUID OF ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENTS Alzheimer's & Dementia. 15: P959-P960. DOI: 10.1016/J.Jalz.2019.06.3116  0.335
2018 Yeh H, Ikezu T. Transcriptional and Epigenetic Regulation of Microglia in Health and Disease. Trends in Molecular Medicine. PMID 30578089 DOI: 10.1016/J.Molmed.2018.11.004  0.776
2018 Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathologica. PMID 30465259 DOI: 10.1007/S00401-018-1937-5  0.45
2018 Ikezu T, Chen C, DeLeo AM, Zeldich E, Fallin MD, Kanaan NM, Lunetta KL, Abraham CR, Logue MW, Farrer LA. Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 29516269 DOI: 10.1007/S11481-018-9781-X  0.815
2018 Apicco DJ, Ash PEA, Maziuk B, LeBlang C, Medalla M, Al Abdullatif A, Ferragud A, Botelho E, Ballance HI, Dhawan U, Boudeau S, Cruz AL, Kashy D, Wong A, Goldberg LR, ... ... Ikezu T, et al. Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo. Nature Neuroscience. 21: 72-80. PMID 29273772 DOI: 10.1038/S41593-017-0022-Z  0.444
2017 Clayton KA, Van Enoo AA, Ikezu T. Alzheimer's Disease: The Role of Microglia in Brain Homeostasis and Proteopathy. Frontiers in Neuroscience. 11: 680. PMID 29311768 DOI: 10.3389/Fnins.2017.00680  0.83
2017 DeLeo AM, Ikezu T. Extracellular Vesicle Biology in Alzheimer's Disease and Related Tauopathy. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 29185187 DOI: 10.1007/S11481-017-9768-Z  0.792
2017 Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, ... ... Ikezu T, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 47: 566-581.e9. PMID 28930663 DOI: 10.1016/J.Immuni.2017.08.008  0.455
2017 Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. The Journal of Biological Chemistry. PMID 28490631 DOI: 10.1074/Jbc.M116.759159  0.782
2017 Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM. Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network. Acta Neuropathologica. PMID 28070672 DOI: 10.1007/S00401-017-1668-Z  0.464
2017 DeLeo AM, Sethi M, Ikezu S, Zaia J, Ikezu T. COMPREHENSIVE CHARACTERIZATION OF HUMAN ALZHEIMER’S DISEASE BRAIN-DERIVED EXOSOMES Alzheimer's & Dementia. 13: P907. DOI: 10.1016/J.Jalz.2017.07.323  0.788
2017 Wolozin B, Apicco DJ, Zhang C, Ash PEA, Maziuk B, Abdullatif AA, Ballance H, Goldberg LR, Yazdani N, Ung C, Kanaan NM, Ikezu T, Bryant CD, Li H. Tau-Induced Neurodegeneration Is Mediated By Rna Binding Proteins Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.07.157  0.314
2017 Logue MW, Chen C, Zeldich E, Fallin MD, Abraham CR, Ikezu T, Farrer LA. Tau Phosphorylation Is Impacted By Rare Ad-Associated Akap9 Mutations Specific To African Americans Alzheimers & Dementia. 13: 969. DOI: 10.1016/J.Jalz.2017.06.1302  0.606
2016 Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson's disease. Nature Communications. 7: 10332. PMID 26755131 DOI: 10.1038/Ncomms10332  0.736
2016 Ikezu T, Ikezu S, Varnum M, Wolozin B, Butovsky O, Kügler S, Medalla M, Luebke J, Haydar TF. O4-04-01: Microglial Exosomes Propagate Tau Protein from the Entorhinal Cortex to the Hippocampus: An Early Pathophysiology of Alzheimer's Disease Alzheimer's & Dementia. 12: P339-P340. DOI: 10.1016/J.Jalz.2016.06.624  0.808
2016 Ikezu T. PL-03-01: INGE Grundke-Iqbal Lecture for Alzheimer’s Research: Exosomes and Microglia in Tau Propagation Alzheimer's & Dementia. 12: P278-P278. DOI: 10.1016/J.Jalz.2016.06.504  0.338
2015 Wolozin B, Ikezu T. Syk and Yea Shall Find. Ebiomedicine. 2: 1590-1. PMID 26870779 DOI: 10.1016/J.Ebiom.2015.11.012  0.479
2015 Sapkota K, Mao Z, Synowicki P, Lieber D, Liu M, Ikezu T, Gautam V, Monaghan DT. GluN2D NMDAR subunit contribution to the stimulation of brain activity and gamma oscillations by ketamine; implications for schizophrenia. The Journal of Pharmacology and Experimental Therapeutics. PMID 26675679 DOI: 10.1124/Jpet.115.230391  0.304
2015 Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nature Neuroscience. 18: 1584-93. PMID 26436904 DOI: 10.1038/Nn.4132  0.833
2015 Varnum MM, Kiyota T, Ingraham KL, Ikezu S, Ikezu T. The anti-inflammatory glycoprotein, CD200, restores neurogenesis and enhances amyloid phagocytosis in a mouse model of Alzheimer's disease. Neurobiology of Aging. 36: 2995-3007. PMID 26315370 DOI: 10.1016/J.Neurobiolaging.2015.07.027  0.799
2015 Woodbury ME, Freilich RW, Cheng CJ, Asai H, Ikezu S, Boucher JD, Slack F, Ikezu T. miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9764-81. PMID 26134658 DOI: 10.1523/Jneurosci.4790-14.2015  0.76
2015 Woodbury M, Kiyota T, Ikezu T. Gene delivery and gene therapy for Alzheimer’s disease Neuromethods. 98: 85-120. DOI: 10.1007/978-1-4939-2306-9_4  0.75
2014 Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, ... ... Ikezu T, et al. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Annals of Neurology. 76: 379-92. PMID 25043464 DOI: 10.1002/Ana.24219  0.805
2014 Ikezu S, Ikezu T. Tau-tubulin kinase. Frontiers in Molecular Neuroscience. 7: 33. PMID 24808823 DOI: 10.3389/Fnmol.2014.00033  0.473
2014 Asai H, Ikezu S, Woodbury ME, Yonemoto GM, Cui L, Ikezu T. Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1. The American Journal of Pathology. 184: 808-18. PMID 24418258 DOI: 10.1016/J.Ajpath.2013.11.026  0.812
2014 Woodbury ME, Ikezu T. Fibroblast growth factor-2 signaling in neurogenesis and neurodegeneration. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 9: 92-101. PMID 24057103 DOI: 10.1007/S11481-013-9501-5  0.551
2013 Freilich RW, Woodbury ME, Ikezu T. Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia. Plos One. 8: e79416. PMID 24244499 DOI: 10.1371/Journal.Pone.0079416  0.761
2013 Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, et al. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. The American Journal of Pathology. 183: 369-81. PMID 23747948 DOI: 10.1016/J.Ajpath.2013.05.005  0.419
2013 McKee AC, Stern RA, Nowinski CJ, Stein TD, Alvarez VE, Daneshvar DH, Lee HS, Wojtowicz SM, Hall G, Baugh CM, Riley DO, Kubilus CA, Cormier KA, Jacobs MA, Martin BR, ... ... Ikezu T, et al. The spectrum of disease in chronic traumatic encephalopathy. Brain : a Journal of Neurology. 136: 43-64. PMID 23208308 DOI: 10.1093/Brain/Aws307  0.599
2013 Asai H, Ikezu S, Sebastian K, Ikezu T. P4-026: The exosomal transcytosis mechanism of tau dissemination through neuron-microglia interaction Alzheimer's & Dementia. 9: P713-P713. DOI: 10.1016/J.Jalz.2013.05.1414  0.747
2013 Jun G, Asai H, Drapeau E, Park J, Zeldich E, Chen C, Kim S, Foroud T, Lunetta K, Kim J, Buxbaum J, Abraham C, Ikezu T, Mayeux R, Farrer L. O4-06-02: Genetic variation in PLXNA4 associated with susceptibility of Alzheimer's disease through tau phosphorylation Alzheimer's & Dementia. 9: P692-P692. DOI: 10.1016/J.Jalz.2013.04.366  0.8
2013 Fisher A, Goldstein L, Tagge C, Velisek L, Wojnarowicz M, Moir R, Casey N, Moncaster J, Nowinski C, Blusztajn J, Wolozin B, Abraham C, Saman S, Upreti C, Ikezu T, et al. O1-07-02: Impact and blast neurotrauma mouse models of chronic traumatic encephalopathy validated by human neuropathology Alzheimer's & Dementia. 9: P141-P141. DOI: 10.1016/J.Jalz.2013.04.087  0.542
2013 Tokuraku K, Ikezu T. Imaging of Amyloidβ Aggregation Using a Novel Quantum dot Nanoprobe and its Advanced Applications Bio-Nanoimaging: Protein Misfolding and Aggregation. 121-131. DOI: 10.1016/B978-0-12-394431-3.00011-0  0.627
2012 Varnum MM, Ikezu T. The classification of microglial activation phenotypes on neurodegeneration and regeneration in Alzheimer's disease brain. Archivum Immunologiae Et Therapiae Experimentalis. 60: 251-66. PMID 22710659 DOI: 10.1007/S00005-012-0181-2  0.812
2012 Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8270-83. PMID 22699908 DOI: 10.1523/Jneurosci.1592-12.2012  0.827
2012 Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, ... ... Ikezu T, et al. Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Science Translational Medicine. 4: 134ra60. PMID 22593173 DOI: 10.1126/Scitranslmed.3003716  0.311
2012 Liu Z, Zhu H, Fang GG, Walsh K, Mwamburi M, Wolozin B, Abdul-Hay SO, Ikezu T, Leissring MA, Qiu WQ. Characterization of insulin degrading enzyme and other amyloid-β degrading proteases in human serum: a role in Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 29: 329-40. PMID 22232014 DOI: 10.3233/Jad-2011-111472  0.368
2012 Kiyota T, Ingraham KL, Swan RJ, Jacobsen MT, Andrews SJ, Ikezu T. AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APPPS1 mice Gene Therapy. 19: 724-733. PMID 21918553 DOI: 10.1038/Gt.2011.126  0.804
2012 Lan X, Kiyota T, Hanamsagar R, Huang Y, Andrews S, Peng H, Zheng JC, Swindells S, Carlson GA, Ikezu T. The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal model. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 412-23. PMID 21826404 DOI: 10.1007/S11481-011-9304-5  0.814
2012 Asai H, Woodbury M, Ikezu S, Varnum M, Ikezu T. P2-144: Accelerated neurodegeneration and phenotypic switch of neuroinflammation in transgenic mice expressing P301L tau-mutant and tau-tubulin kinase 1 Alzheimer's & Dementia. 8: P309-P309. DOI: 10.1016/J.Jalz.2012.05.849  0.801
2012 Asai H, Ikezu S, Varnum M, Ikezu T. P4-040: Phosphorylation of collapsin response mediator protein-2 and axonal degeneration in transgenic mice expressing a familial Alzheimer's disease mutant of APP and tau-tubulin kinase 1 Alzheimer's & Dementia. 8: P649-P650. DOI: 10.1016/J.Jalz.2012.05.1741  0.813
2011 Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders. Proceedings of the National Academy of Sciences of the United States of America. 108: E1339-48. PMID 22042871 DOI: 10.1073/Pnas.1102349108  0.814
2011 Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T. HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes. Journal of Immunology (Baltimore, Md. : 1950). 186: 6925-32. PMID 21551363 DOI: 10.4049/Jimmunol.1100211  0.777
2011 Freilich RW, Ikezu T. Neuroimmune pharmacology as a sub-discipline of medical neuroscience in the medical school curriculum. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 6: 41-56. PMID 21103946 DOI: 10.1007/S11481-010-9250-7  0.761
2011 Xu J, Tsutsumi K, Tokuraku K, Estes KA, Hisanaga S, Ikezu T. Actin interaction and regulation of cyclin-dependent kinase 5/p35 complex activity. Journal of Neurochemistry. 116: 192-204. PMID 20492361 DOI: 10.1111/J.1471-4159.2010.06824.X  0.755
2011 Kiyota T, Ingraham KL, Jacobsen MT, Xiong H, Ikezu T. FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders (Proceedings of the National Academy of Sciences of the United States of America (2011), 108, (E1339-E1348) DOI: 10.1073/pnas.1102349108) Proceedings of the National Academy of Sciences of the United States of America. 108: 21282. DOI: 10.1073/Pnas.1119280109  0.784
2011 Yamamoto M, Ikezu T. CCR2 chemokine receptor Xpharm: the Comprehensive Pharmacology Reference. 1-7. DOI: 10.1016/B978-008055232-3.60187-4  0.663
2011 Yamamoto M, Ikezu T. CCR1 chemokine receptor Xpharm: the Comprehensive Pharmacology Reference. 1-10. DOI: 10.1016/B978-008055232-3.60185-0  0.662
2010 Flaherty DP, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers. Journal of Medicinal Chemistry. 53: 7992-9. PMID 21038854 DOI: 10.1021/Jm1006929  0.789
2010 Tokuraku K, Okuyama S, Matsushima K, Ikezu T, Kotani S. Distinct neuronal localization of microtubule-associated protein 4 in the mammalian brain. Neuroscience Letters. 484: 143-7. PMID 20727942 DOI: 10.1016/J.Neulet.2010.08.038  0.747
2010 Kiyota T, Okuyama S, Swan RJ, Jacobsen MT, Gendelman HE, Ikezu T. CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 3093-102. PMID 20371618 DOI: 10.1096/Fj.10-155317  0.82
2010 Xu J, Sato S, Okuyama S, Swan RJ, Jacobsen MT, Strunk E, Ikezu T. Tau-tubulin kinase 1 enhances prefibrillar tau aggregation and motor neuron degeneration in P301L FTDP-17 tau-mutant mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2904-15. PMID 20354135 DOI: 10.1096/Fj.09-150144  0.822
2009 Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS Gene Delivery of Dominant-negative CCL2 Mutant Suppresses Gliosis, β-amyloidosis, and Learning Impairment of APP/PS1 Mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 803-809. PMID 28189021 DOI: 10.1038/mt.2009.44  0.825
2009 Tokuraku K, Marquardt M, Ikezu T. Real-time imaging and quantification of amyloid-beta peptide aggregates by novel quantum-dot nanoprobes. Plos One. 4: e8492. PMID 20041162 DOI: 10.1371/Journal.Pone.0008492  0.649
2009 Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. Plos One. 4: e6197. PMID 19593388 DOI: 10.1371/Journal.Pone.0006197  0.828
2009 Ikezu T. The aging of human-immunodeficiency-virus-associated neurocognitive disorders. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 161-2. PMID 19415503 DOI: 10.1007/S11481-009-9155-5  0.368
2009 Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 803-9. PMID 19277012 DOI: 10.1038/Mt.2009.44  0.826
2009 Buescher JL, Martinez LB, Sato S, Okuyama S, Ikezu T. YY1 and FoxD3 regulate antiretroviral zinc finger protein OTK18 promoter activation induced by HIV-1 infection. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 103-15. PMID 19034670 DOI: 10.1007/S11481-008-9139-X  0.623
2009 Martinez LB, Walsh SM, Jacobsen MT, Sato S, Wiederin J, Ciborowski P, Ikezu T. Calpain and proteasomal regulation of antiretroviral zinc finger protein OTK18 in human macrophages: visualization in live cells by intramolecular FRET. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 116-28. PMID 19034669 DOI: 10.1007/S11481-008-9140-4  0.735
2009 Xu J, Ikezu T. The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 200-12. PMID 19016329 DOI: 10.1007/S11481-008-9136-0  0.692
2009 Tokuraku K, Marquardt M, Ikezu T. 1P-263 Imaging of amyloid-beta peptide aggregation in vitro and in vivo by a quantum dot-based nanoprobe(Bioimaging, The 47th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri. 49. DOI: 10.2142/Biophys.49.S103_5  0.623
2008 Sato S, Xu J, Okuyama S, Martinez LB, Walsh SM, Jacobsen MT, Swan RJ, Schlautman JD, Ciborowski P, Ikezu T. Spatial learning impairment, enhanced CDK5/p35 activity, and downregulation of NMDA receptor expression in transgenic mice expressing tau-tubulin kinase 1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14511-21. PMID 19118186 DOI: 10.1523/Jneurosci.3417-08.2008  0.821
2008 Yamamoto M, Kiyota T, Walsh SM, Liu J, Kipnis J, Ikezu T. Cytokine-mediated inhibition of fibrillar amyloid-beta peptide degradation by human mononuclear phagocytes. Journal of Immunology (Baltimore, Md. : 1950). 181: 3877-86. PMID 18768842 DOI: 10.4049/Jimmunol.181.6.3877  0.805
2008 Yamamoto M, Ramirez SH, Sato S, Kiyota T, Cerny RL, Kaibuchi K, Persidsky Y, Ikezu T. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. The American Journal of Pathology. 172: 521-33. PMID 18187566 DOI: 10.2353/Ajpath.2008.070076  0.792
2008 Ikezu T, Kiyota T, Yamamoto M, Xu J, Jacobsen MT, Okuyama S. O1-04-08: Therapeutic application of anti-inflammatory cytokines an Abeta-induced cognitive dysfunction Alzheimer's & Dementia. 4: T116-T117. DOI: 10.1016/J.Jalz.2008.05.245  0.77
2008 Ikezu T. Alzheimer's disease Neuroimmune Pharmacology. 343-362. DOI: 10.1007/978-0-387-72573-4_25  0.351
2007 Yamamoto M, Kiyota T, Walsh SM, Ikezu T. Kinetic analysis of aggregated amyloid-beta peptide clearance in adult bone-marrow-derived macrophages from APP and CCL2 transgenic mice. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 2: 213-21. PMID 18040846 DOI: 10.1007/S11481-006-9049-8  0.814
2007 Gorantla S, Liu J, Sneller H, Dou H, Holguin A, Smith L, Ikezu T, Volsky DJ, Poluektova L, Gendelman HE. Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 179: 4345-56. PMID 17878329 DOI: 10.4049/Jimmunol.179.7.4345  0.331
2007 Flaherty DP, Walsh SM, Kiyota T, Dong Y, Ikezu T, Vennerstrom JL. Polyfluorinated bis-styrylbenzene beta-amyloid plaque binding ligands. Journal of Medicinal Chemistry. 50: 4986-92. PMID 17845017 DOI: 10.1021/Jm070085F  0.799
2007 Yamamoto M, Kiyota T, Horiba M, Buescher JL, Walsh SM, Gendelman HE, Ikezu T. Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. The American Journal of Pathology. 170: 680-92. PMID 17255335 DOI: 10.2353/Ajpath.2007.060378  0.806
2007 Horiba M, Martinez LB, Buescher JL, Sato S, Limoges J, Jiang Y, Jones C, Ikezu T. OTK18, a zinc-finger protein, regulates human immunodeficiency virus type 1 long terminal repeat through two distinct regulatory regions. The Journal of General Virology. 88: 236-41. PMID 17170456 DOI: 10.1099/Vir.0.82066-0  0.728
2006 Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. Journal of Neurochemistry. 98: 1573-84. PMID 16923168 DOI: 10.1111/J.1471-4159.2006.04059.X  0.428
2006 Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, Shimokawa H, Kaibuchi K, Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood. 107: 4770-80. PMID 16478881 DOI: 10.1182/Blood-2005-11-4721  0.347
2006 Ikezu T, Buescher J, Cerny R, Sato S. Tau tubulin kinase-1 and amyloid-beta peptide oligomer induce tau phosphorylation, aggregation, and reduced microtubule polymerization Nanomedicine: Nanotechnology, Biology and Medicine. 2: 312. DOI: 10.1016/J.Nano.2006.10.134  0.393
2006 DeLeo AM, Sethi M, Muraoka S, Ruan Z, Ikezu S, Golantla S, Gendelman HE, Zaia J, Ikezu T. O2-01-02: CHARACTERIZATION OF HUMAN ALZHEIMER'S DISEASE BRAIN-DERIVED EXOSOMES Alzheimer's & Dementia. 14: P608-P608. DOI: 10.1016/J.Jalz.2018.06.2640  0.799
2006 DeLeo AM, Muraoka S, Stern RA, Ikezu T. P3-086: PROTEOMIC ANALYSIS OF EXOSOMES DERIVED FROM PLASMA SAMPLES OF FORMER NATIONAL FOOTBALL LEAGUE PLAYERS Alzheimer's & Dementia. 14: P1098-P1098. DOI: 10.1016/J.Jalz.2018.06.1442  0.752
2006 Ruan Z, DeLeo AM, Yoshii-Kitahara A, Ikezu S, Kayed R, Golantla S, Gendelman HE, Ikezu T. P1-025: EXOSOMES CONTAINING SPECIFIC TAU OLIGOMER FORMATIONS ACCELERATE PATHOLOGICAL TAU PHOSPHORYLATION IN C57BL/6 MICE Alzheimer's & Dementia. 14: P275-P275. DOI: 10.1016/J.Jalz.2018.06.026  0.796
2005 Yamamoto M, Horiba M, Buescher JL, Huang D, Gendelman HE, Ransohoff RM, Ikezu T. Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition. The American Journal of Pathology. 166: 1475-85. PMID 15855647 DOI: 10.1016/S0002-9440(10)62364-4  0.823
2004 Xiong H, McCabe L, Costello J, Anderson E, Weber G, Ikezu T. Activation of NR1a/NR2B receptors by soluble factors from APP-stimulated monocyte-derived macrophages: implications for the pathogenesis of Alzheimer's disease. Neurobiology of Aging. 25: 905-11. PMID 15212844 DOI: 10.1016/J.Neurobiolaging.2003.09.007  0.413
2004 Carlson KA, Limoges J, Pohlman GD, Poluektova LY, Langford D, Masliah E, Ikezu T, Gendelman HE. OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis. Journal of Neuroimmunology. 150: 186-98. PMID 15081264 DOI: 10.1016/J.Jneuroim.2004.01.021  0.311
2004 Carlson KA, Leisman G, Limoges J, Pohlman GD, Horiba M, Buescher J, Gendelman HE, Ikezu T. Molecular characterization of a putative antiretroviral transcriptional factor, OTK18. Journal of Immunology (Baltimore, Md. : 1950). 172: 381-91. PMID 14688346 DOI: 10.4049/Jimmunol.172.1.381  0.724
2003 Ikezu T, Luo X, Weber GA, Zhao J, McCabe L, Buescher JL, Ghorpade A, Zheng J, Xiong H. Amyloid precursor protein-processing products affect mononuclear phagocyte activation: pathways for sAPP- and Abeta-mediated neurotoxicity. Journal of Neurochemistry. 85: 925-34. PMID 12716424 DOI: 10.1046/J.1471-4159.2003.01739.X  0.703
2003 Luo X, Weber GA, Zheng J, Gendelman HE, Ikezu T. C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease. Journal of Neuroimmunology. 135: 62-71. PMID 12576225 DOI: 10.1016/S0165-5728(02)00444-7  0.669
1999 Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 upregulation activates beta-secretase-mediated cleavage of the amyloid precursor protein in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6538-48. PMID 10414982  0.366
1999 Nishiyama K, Trapp BD, Ikezu T, Ransohoff RM, Tomita T, Iwatsubo T, Kanazawa I, Hsiao KK, Lisanti MP, Okamoto T. Caveolin-3 Upregulation Activates β-Secretase–Mediated Cleavage of the Amyloid Precursor Protein in Alzheimer’s Disease The Journal of Neuroscience. 19: 6538-6548. DOI: 10.1523/Jneurosci.19-15-06538.1999  0.455
1998 Ikezu T, Ueda H, Trapp BD, Nishiyama K, Sha JF, Volonte D, Galbiati F, Byrd AL, Bassell G, Serizawa H, Lane WS, Lisanti MP, Okamoto T. Affinity-purification and characterization of caveolins from the brain: differential expression of caveolin-1, -2, and -3 in brain endothelial and astroglial cell types. Brain Research. 804: 177-92. PMID 9841091 DOI: 10.1016/S0006-8993(98)00498-3  0.329
1998 Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, Lisanti MP. Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. Febs Letters. 428: 205-11. PMID 9654135 DOI: 10.1016/S0014-5793(98)00470-0  0.314
1998 Ikezu T, Trapp BD, Song KS, Schlegel A, Lisanti MP, Okamoto T. Caveolae, plasma membrane microdomains for alpha-secretase-mediated processing of the amyloid precursor protein. The Journal of Biological Chemistry. 273: 10485-95. PMID 9553108 DOI: 10.1074/Jbc.273.17.10485  0.365
1997 Giambarella U, Yamatsuji T, Okamoto T, Matsui T, Ikezu T, Murayama Y, Levine MA, Katz A, Gautam N, Nishimoto I. G protein betagamma complex-mediated apoptosis by familial Alzheimer's disease mutant of APP. The Embo Journal. 16: 4897-907. PMID 9305632 DOI: 10.1093/Emboj/16.16.4897  0.319
1997 Giambarella U, Murayama Y, Ikezu T, Fujita T, Nishimoto I. Potential CRE suppression by familial Alzheimer's mutants of APP independent of adenylyl cyclase regulation Febs Letters. 412: 97-101. PMID 9257698 DOI: 10.1016/S0014-5793(97)00753-9  0.369
1996 Ikezu T, Okamoto T, Komatsuzaki K, Matsui T, Jeevendra Martyn JA, Nishimoto I. Negative transactivation of cAMP response element by familial Alzheimer's mutants of APP Embo Journal. 15: 2468-2475. PMID 8665854 DOI: 10.1002/J.1460-2075.1996.Tb00604.X  0.388
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