Ian Holt, Ph.D.

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Spinazzola A, Perez-Rodriguez D, Ježek J, et al. (2024) Mitochondrial DNA competition: starving out the mutant genome. Trends in Pharmacological Sciences. 45: 225-242
Holt IJ. (2022) R-Loops and Mitochondrial DNA Metabolism. Methods in Molecular Biology (Clifton, N.J.). 2528: 173-202
Aiestaran-Zelaia I, Sánchez-Guisado MJ, Villar-Fernandez M, et al. (2022) 2 deoxy-D-glucose augments the mitochondrial respiratory chain in heart. Scientific Reports. 12: 6890
Pantic B, Ives D, Mennuni M, et al. (2021) 2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA. Nature Communications. 12: 6997
Horga A, Manole A, Mitchell AL, et al. (2021) Uniparental isodisomy of chromosome 2 causing MRPL44-related multisystem mitochondrial disease. Molecular Biology Reports
Gunning AC, Strucinska K, Muñoz Oreja M, et al. (2020) Recurrent De Novo NAHR Reciprocal Duplications in the ATAD3 Gene Cluster Cause a Neurogenetic Trait with Perturbed Cholesterol and Mitochondrial Metabolism. American Journal of Human Genetics
De la Casa-Fages B, Fernández-Eulate G, Gamez J, et al. (2019) Reply to: "Mitochondrial Parkinsonism due to SPG7/Paraplegin variants with secondary mtDNA depletion". Movement Disorders : Official Journal of the Movement Disorder Society. 34: 1932-1933
De la Casa-Fages B, Fernández-Eulate G, Gamez J, et al. (2019) Parkinsonism and spastic paraplegia type 7: Expanding the spectrum of mitochondrial Parkinsonism. Movement Disorders : Official Journal of the Movement Disorder Society
Holt IJ. (2019) The Jekyll and Hyde character of RNase H1 and its multiple roles in mitochondrial DNA metabolism. Dna Repair
Holt IJ. (2019) The mitochondrial R-loop. Nucleic Acids Research