cached image

Joseph Heitman, PhD,MD - Publications

Molecular Genetics & Microbiology Duke University, Durham, NC 
Sex in Fungi, Signaling, Pathogenesis, Cryptococcus,

225 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sun S, Lin X, Coelho MA, Heitman J. Mating-System Evolution: All Roads Lead to Selfing. Current Biology : Cb. 29: R743-R746. PMID 31386850 DOI: 10.1016/j.cub.2019.06.073  0.52
2019 Passer AR, Coelho MA, Billmyre RB, Nowrousian M, Mittelbach M, Yurkov AM, Averette AF, Cuomo CA, Sun S, Heitman J. Genetic and Genomic Analyses Reveal Boundaries between Species Closely Related to Pathogens. Mbio. 10. PMID 31186317 DOI: 10.1128/mBio.00764-19  0.52
2019 Mueller KD, Zhang H, Serrano CR, Billmyre RB, Huh EY, Wiemann P, Keller NP, Wang Y, Heitman J, Lee SC. Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model. Journal of Microbiology (Seoul, Korea). PMID 31012059 DOI: 10.1007/s12275-019-8682-x  0.52
2019 Rutherford JC, Bahn YS, van den Berg B, Heitman J, Xue C. Nutrient and Stress Sensing in Pathogenic Yeasts. Frontiers in Microbiology. 10: 442. PMID 30930866 DOI: 10.3389/fmicb.2019.00442  0.64
2019 Chang Z, Billmyre RB, Lee SC, Heitman J. Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides. Plos Genetics. 15: e1007957. PMID 30742617 DOI: 10.1371/journal.pgen.1007957  0.52
2018 Gryganskyi AP, Golan J, Dolatabadi S, Mondo S, Robb S, Idnurm A, Muszewska A, Steczkiewicz K, Masonjones S, Liao HL, Gajdeczka MT, Anike F, Vuek A, Anishchenko IM, Voigt K, ... ... Heitman J, et al. Phylogenetic and Phylogenomic Definition of Species. G3 (Bethesda, Md.). PMID 29674435 DOI: 10.1534/g3.118.200235  0.6
2018 Roth C, Sun S, Billmyre RB, Heitman J, Magwene PM. A High Resolution Map of Meiotic Recombination inDemonstrates Decreased Recombination in Unisexual Reproduction. Genetics. PMID 29625994 DOI: 10.1534/genetics.118.300996  0.52
2018 Yadav V, Sun S, Billmyre RB, Thimmappa BC, Shea T, Lintner R, Bakkeren G, Cuomo CA, Heitman J, Sanyal K. RNAi is a critical determinant of centromere evolution in closely related fungi. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507212 DOI: 10.1073/pnas.1713725115  0.52
2018 Persinoti GF, Martinez DA, Li W, Döğen A, Billmyre RB, Averette A, Goldberg JM, Shea T, Young S, Zeng Q, Oliver BG, Barton R, Metin B, Hilmioğlu-Polat S, Ilkit M, ... ... Heitman J, et al. Whole Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen. Genetics. PMID 29467168 DOI: 10.1534/genetics.117.300573  0.52
2017 Jung WH, Son YE, Oh SH, Fu C, Kim HS, Kwak JH, Cardenas ME, Heitman J, Park HS. Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans. G3 (Bethesda, Md.). PMID 29233914 DOI: 10.1534/g3.117.300444  0.72
2017 Fu C, Donadio N, Cardenas ME, Heitman J. Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans. Genetics. PMID 29233811 DOI: 10.1534/genetics.117.300422  0.72
2017 Billmyre RB, Clancey SA, Heitman J. Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii. Elife. 6. PMID 28948913 DOI: 10.7554/eLife.28802  0.52
2017 Billmyre RB, Heitman J. Genetic and epigenetic engines of diversity in pathogenic microbes. Plos Pathogens. 13: e1006468. PMID 28910393 DOI: 10.1371/journal.ppat.1006468  0.52
2017 Sun S, Yadav V, Billmyre RB, Cuomo CA, Nowrousian M, Wang L, Souciet JL, Boekhout T, Porcel B, Wincker P, Granek JA, Sanyal K, Heitman J. Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. Plos Biology. 15: e2002527. PMID 28800596 DOI: 10.1371/journal.pbio.2002527  0.52
2017 Rhodes J, Desjardins CA, Sykes SM, Beale MA, Vanhove M, Sakthikumar S, Chen Y, Gujja S, Saif S, Chowdhary A, Lawson DJ, Ponzio V, Colombo AL, Meyer W, Engelthaler DM, ... ... Heitman J, et al. Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level. Genetics. PMID 28679543 DOI: 10.1534/genetics.117.203836  0.4
2017 Desjardins CA, Giamberardino C, Sykes SM, Yu CH, Tenor JL, Chen Y, Yang T, Jones AM, Sun S, Haverkamp MR, Heitman J, Litvintseva AP, Perfect JR, Cuomo CA. Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans. Genome Research. PMID 28611159 DOI: 10.1101/gr.218727.116  0.4
2017 Chow EW, Clancey SA, Billmyre RB, Averette AF, Granek JA, Mieczkowski P, Cardenas ME, Heitman J. Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans. Plos Genetics. 13: e1006667. PMID 28376087 DOI: 10.1371/journal.pgen.1006667  0.72
2017 Calo S, Nicolás FE, Lee SC, Vila A, Cervantes M, Torres-Martinez S, Ruiz-Vazquez RM, Cardenas ME, Heitman J. A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. Plos Genetics. 13: e1006686. PMID 28339467 DOI: 10.1371/journal.pgen.1006686  0.72
2017 Zhu Y, Engström PG, Tellgren-Roth C, Baudo CD, Kennell JC, Sun S, Billmyre RB, Schröder MS, Andersson A, Holm T, Sigurgeirsson B, Wu G, Sankaranarayanan SR, Siddharthan R, Sanyal K, ... ... Heitman J, et al. Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis. Nucleic Acids Research. PMID 28100699 DOI: 10.1093/nar/gkx006  0.52
2016 Ianiri G, Averette AF, Kingsbury JM, Heitman J, Idnurm A. Gene Function Analysis in the Ubiquitous Human Commensal and Pathogen Malassezia Genus. Mbio. 7. PMID 27899504 DOI: 10.1128/mBio.01853-16  0.6
2016 Yang DH, Jung KW, Bang S, Lee JW, Song MH, Floyd-Averette A, Festa RA, Ianiri G, Idnurm A, Thiele DJ, Heitman J, Bahn YS. Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans. Genetics. PMID 27866167 DOI: 10.1534/genetics.116.190595  0.6
2016 Lee KT, So YS, Yang DH, Jung KW, Choi J, Lee DG, Kwon H, Jang J, Wang LL, Cha S, Meyers GL, Jeong E, Jin JH, Lee Y, Hong J, ... ... Heitman J, et al. Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans. Nature Communications. 7: 12766. PMID 27677328 DOI: 10.1038/ncomms12766  1
2016 Park HS, Chow EW, Fu C, Soderblom EJ, Moseley MA, Heitman J, Cardenas ME. Calcineurin Targets Involved in Stress Survival and Fungal Virulence. Plos Pathogens. 12: e1005873. PMID 27611567 DOI: 10.1371/journal.ppat.1005873  0.72
2016 Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, ... ... Heitman J, et al. Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. Nature Chemical Biology. PMID 27571477 DOI: 10.1038/nchembio.2165  1
2016 Kingsbury JM, Shamaprasad N, Billmyre RB, Heitman J, Cardenas ME. Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability. Human Molecular Genetics. PMID 27427385 DOI: 10.1093/hmg/ddw195  0.72
2016 Juvvadi PR, Lee SC, Heitman J, Steinbach WJ. Calcineurin in Fungal Virulence and Drug Resistance: Prospects for Harnessing Targeted Inhibition of Calcineurin for an Antifungal Therapeutic Approach. Virulence. 0. PMID 27325145 DOI: 10.1080/21505594.2016.1201250  0.4
2016 Corrochano LM, Kuo A, Marcet-Houben M, Polaino S, Salamov A, Villalobos-Escobedo JM, Grimwood J, Álvarez MI, Avalos J, Bauer D, Benito EP, Benoit I, Burger G, Camino LP, Cánovas D, ... ... Heitman J, et al. Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication. Current Biology : Cb. PMID 27238284 DOI: 10.1016/j.cub.2016.04.038  1
2016 Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA. Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio. 7. PMID 27118592 DOI: 10.1128/mBio.00492-16  0.4
2016 Feretzaki M, Billmyre RB, Clancey SA, Wang X, Heitman J. Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex. Plos Genetics. 12: e1005868. PMID 26943821 DOI: 10.1371/journal.pgen.1005868  0.52
2015 Heitman J. Evolution of sexual reproduction: a view from the Fungal Kingdom supports an evolutionary epoch with sex before sexes. Fungal Biology Reviews. 29: 108-117. PMID 26834823 DOI: 10.1016/j.fbr.2015.08.002  1
2015 Sun S, Heitman J. From Two to One: Unipolar Sexual Reproduction. Fungal Biology Reviews. 29: 118-125. PMID 26744600 DOI: 10.1016/j.fbr.2015.06.002  1
2015 Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GD. An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. Cell Reports. PMID 26549450 DOI: 10.1016/j.celrep.2015.10.018  1
2015 Wu G, Zhao H, Li C, Rajapakse MP, Wong WC, Xu J, Saunders CW, Reeder NL, Reilman RA, Scheynius A, Sun S, Billmyre BR, Li W, Averette AF, Mieczkowski P, ... Heitman J, et al. Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin. Plos Genetics. 11: e1005614. PMID 26539826 DOI: 10.1371/journal.pgen.1005614  0.44
2015 Farrer RA, Desjardins CA, Sakthikumar S, Gujja S, Saif S, Zeng Q, Chen Y, Voelz K, Heitman J, May RC, Fisher MC, Cuomo CA. Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii. Mbio. 6: e00868-15. PMID 26330512 DOI: 10.1128/mBio.00868-15  1
2015 Kourist R, Bracharz F, Lorenzen J, Kracht ON, Chovatia M, Daum C, Deshpande S, Lipzen A, Nolan M, Ohm RA, Grigoriev IV, Sun S, Heitman J, Brück T, Nowrousian M. Genomics and Transcriptomics Analyses of the Oil-Accumulating Basidiomycete Yeast Trichosporon oleaginosus: Insights into Substrate Utilization and Alternative Evolutionary Trajectories of Fungal Mating Systems. Mbio. 6: e00918. PMID 26199329 DOI: 10.1128/mBio.00918-15  1
2015 Desnos-Ollivier M, Patel S, Raoux-Barbot D, Heitman J, Dromer F. Cryptococcosis Serotypes Impact Outcome and Provide Evidence of Cryptococcus neoformans Speciation. Mbio. 6. PMID 26060271 DOI: 10.1128/mBio.00311-15  1
2015 Lee SC, Li A, Calo S, Inoue M, Tonthat NK, Bain JM, Louw J, Shinohara ML, Erwig LP, Schumacher MA, Ko DC, Heitman J. Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. Molecular Microbiology. PMID 26010100 DOI: 10.1111/mmi.13071  1
2015 Jung KW, Yang DH, Maeng S, Lee KT, So YS, Hong J, Choi J, Byun HJ, Kim H, Bang S, Song MH, Lee JW, Kim MS, Kim SY, Ji JH, ... ... Heitman J, et al. Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. Nature Communications. 6: 6757. PMID 25849373 DOI: 10.1038/ncomms7757  1
2015 Oh DY, Madhusoodhan PP, Springer DJ, Inglima K, Chaudhri AA, Heitman J, Raetz EA, Khaitan A, Rigaud M. Cryptococcal osteomyelitis in an adolescent survivor of T-cell acute lymphoblastic leukemia. The Pediatric Infectious Disease Journal. 34: 662-6. PMID 25806844 DOI: 10.1097/INF.0000000000000687  1
2015 Kim H, Jung KW, Maeng S, Chen YL, Shin J, Shim JE, Hwang S, Janbon G, Kim T, Heitman J, Bahn YS, Lee I. Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans. Scientific Reports. 5: 8767. PMID 25739925 DOI: 10.1038/srep08767  1
2015 Fu C, Sun S, Billmyre RB, Roach KC, Heitman J. Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts. Fungal Genetics and Biology : Fg & B. 78: 65-75. PMID 25173822 DOI: 10.1016/j.fgb.2014.08.008  1
2015 Tiro AV, Springer DJ, Irby R, Averill F, Ottaviani A, Heitman J, Perfect JR. A case of cryptococcus gattii in Western Florida: An aggressive pathogen in an immunocompetent host Infectious Diseases in Clinical Practice. 23: 105-108. DOI: 10.1097/IPC.0000000000000211  1
2014 Sun S, Billmyre RB, Mieczkowski PA, Heitman J. Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans. Plos Genetics. 10: e1004849. PMID 25503976 DOI: 10.1371/journal.pgen.1004849  1
2014 Phadke SS, Feretzaki M, Clancey SA, Mueller O, Heitman J. Unisexual reproduction of Cryptococcus gattii. Plos One. 9: e111089. PMID 25337713 DOI: 10.1371/journal.pone.0111089  1
2014 Wollschlaeger C, Trevijano-Contador N, Wang X, Legrand M, Zaragoza O, Heitman J, Janbon G. Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating. Fungal Genetics and Biology : Fg & B. 73: 20-8. PMID 25267175 DOI: 10.1016/j.fgb.2014.09.007  1
2014 Ferreira-Paim K, Ferreira TB, Andrade-Silva L, Mora DJ, Springer DJ, Heitman J, Fonseca FM, Matos D, Melhem MS, Silva-Vergara ML. Phylogenetic analysis of phenotypically characterized Cryptococcus laurentii isolates reveals high frequency of cryptic species. Plos One. 9: e108633. PMID 25251413 DOI: 10.1371/journal.pone.0108633  1
2014 Roach KC, Heitman J. Unisexual reproduction reverses Muller's ratchet. Genetics. 198: 1059-69. PMID 25217049 DOI: 10.1534/genetics.114.170472  1
2014 Lee SC, Heitman J. Sex in the Mucoralean fungi. Mycoses. 57: 18-24. PMID 25175551 DOI: 10.1111/myc.12244  1
2014 Springer DJ, Billmyre RB, Filler EE, Voelz K, Pursall R, Mieczkowski PA, Larsen RA, Dietrich FS, May RC, Filler SG, Heitman J. Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal. Plos Pathogens. 10: e1004285. PMID 25144534 DOI: 10.1371/journal.ppat.1004285  1
2014 Feretzaki M, Hardison SE, Wormley FL, Heitman J. Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. Plos One. 9: e104432. PMID 25093333 DOI: 10.1371/journal.pone.0104432  1
2014 Heitman J, Carter DA, Dyer PS, Soll DR. Sexual reproduction of human fungal pathogens. Cold Spring Harbor Perspectives in Medicine. 4. PMID 25085958 DOI: 10.1101/cshperspect.a019281  1
2014 Calo S, Shertz-Wall C, Lee SC, Bastidas RJ, Nicolás FE, Granek JA, Mieczkowski P, Torres-Martínez S, Ruiz-Vázquez RM, Cardenas ME, Heitman J. Antifungal drug resistance evoked via RNAi-dependent epimutations. Nature. 513: 555-8. PMID 25079329 DOI: 10.1038/nature13575  1
2014 Billmyre RB, Croll D, Li W, Mieczkowski P, Carter DA, Cuomo CA, Kronstad JW, Heitman J. Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution. Mbio. 5: e01494-14. PMID 25073643 DOI: 10.1128/mBio.01494-14  1
2014 Lee SC, Billmyre RB, Li A, Carson S, Sykes SM, Huh EY, Mieczkowski P, Ko DC, Cuomo CA, Heitman J. Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt. Mbio. 5: e01390-14. PMID 25006230 DOI: 10.1128/mBio.01390-14  1
2014 Roach KC, Feretzaki M, Sun S, Heitman J. Unisexual reproduction. Advances in Genetics. 85: 255-305. PMID 24880737 DOI: 10.1016/B978-0-12-800271-1.00005-6  1
2014 Janbon G, Ormerod KL, Paulet D, Byrnes EJ, Yadav V, Chatterjee G, Mullapudi N, Hon CC, Billmyre RB, Brunel F, Bahn YS, Chen W, Chen Y, Chow EW, Coppée JY, ... ... Heitman J, et al. Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. Plos Genetics. 10: e1004261. PMID 24743168 DOI: 10.1371/journal.pgen.1004261  1
2014 Goodenough U, Heitman J. Origins of eukaryotic sexual reproduction. Cold Spring Harbor Perspectives in Biology. 6. PMID 24591519 DOI: 10.1101/cshperspect.a016154  1
2014 Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, et al. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. Mbio. 5: e00765-13. PMID 24520056 DOI: 10.1128/mBio.00765-13  1
2014 Kingsbury JM, Sen ND, Maeda T, Heitman J, Cardenas ME. Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae. Genetics. 196: 1077-89. PMID 24514902 DOI: 10.1534/genetics.114.161646  1
2014 Chen YL, Yu SJ, Huang HY, Chang YL, Lehman VN, Silao FG, Bigol UG, Bungay AA, Averette A, Heitman J. Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis. Eukaryotic Cell. 13: 844-54. PMID 24442892 DOI: 10.1128/EC.00302-13  1
2014 Lee SC, Sun S, Heitman J. Unseen sex in ancient virgin fungi. The New Phytologist. 201: 3-5. PMID 24274789 DOI: 10.1111/nph.12564  1
2014 Lee SC, Heitman J, Ironside JE. Sex and the Microsporidia Microsporidia: Pathogens of Opportunity: First Edition. 231-243. DOI: 10.1002/9781118395264.ch8  1
2013 Umen J, Heitman J. Evolution of sex: mating rituals of a pre-metazoan. Current Biology : Cb. 23: R1006-8. PMID 24262825 DOI: 10.1016/j.cub.2013.10.009  1
2013 Feretzaki M, Heitman J. Unisexual reproduction drives evolution of eukaryotic microbial pathogens. Plos Pathogens. 9: e1003674. PMID 24204257 DOI: 10.1371/journal.ppat.1003674  1
2013 Billmyre RB, Calo S, Feretzaki M, Wang X, Heitman J. RNAi function, diversity, and loss in the fungal kingdom. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 21: 561-72. PMID 24173579 DOI: 10.1007/s10577-013-9388-2  1
2013 Kozubowski L, Yadav V, Chatterjee G, Sridhar S, Yamaguchi M, Kawamoto S, Bose I, Heitman J, Sanyal K. Ordered kinetochore assembly in the human-pathogenic basidiomycetous yeast Cryptococcus neoformans. Mbio. 4: e00614-13. PMID 24085781 DOI: 10.1128/mBio.00614-13  1
2013 Ni M, Feretzaki M, Li W, Floyd-Averette A, Mieczkowski P, Dietrich FS, Heitman J. Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans. Plos Biology. 11: e1001653. PMID 24058295 DOI: 10.1371/journal.pbio.1001653  1
2013 Voelz K, Ma H, Phadke S, Byrnes EJ, Zhu P, Mueller O, Farrer RA, Henk DA, Lewit Y, Hsueh YP, Fisher MC, Idnurm A, Heitman J, May RC. Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii. Plos Genetics. 9: e1003771. PMID 24039607 DOI: 10.1371/journal.pgen.1003771  1
2013 Lee SC, Li A, Calo S, Heitman J. Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloides. Plos Pathogens. 9: e1003625. PMID 24039585 DOI: 10.1371/journal.ppat.1003625  1
2013 Feretzaki M, Heitman J. Genetic circuits that govern bisexual and unisexual reproduction in Cryptococcus neoformans. Plos Genetics. 9: e1003688. PMID 23966871 DOI: 10.1371/journal.pgen.1003688  1
2013 James TY, Sun S, Li W, Heitman J, Kuo HC, Lee YH, Asiegbu FO, Olson A. Polyporales genomes reveal the genetic architecture underlying tetrapolar and bipolar mating systems. Mycologia. 105: 1374-90. PMID 23928418 DOI: 10.3852/13-162  1
2013 Springer DJ, Saini D, Byrnes EJ, Heitman J, Frothingham R. Development of an aerosol model of Cryptococcus reveals humidity as an important factor affecting the viability of Cryptococcus during aerosolization. Plos One. 8: e69804. PMID 23894542 DOI: 10.1371/journal.pone.0069804  1
2013 Ravu RR, Chen YL, Jacob MR, Pan X, Agarwal AK, Khan SI, Heitman J, Clark AM, Li XC. Synthesis and antifungal activities of miltefosine analogs. Bioorganic & Medicinal Chemistry Letters. 23: 4828-31. PMID 23891181 DOI: 10.1016/j.bmcl.2013.06.096  1
2013 Martin MD, Cappellini E, Samaniego JA, Zepeda ML, Campos PF, Seguin-Orlando A, Wales N, Orlando L, Ho SY, Dietrich FS, Mieczkowski PA, Heitman J, Willerslev E, Krogh A, Ristaino JB, et al. Reconstructing genome evolution in historic samples of the Irish potato famine pathogen. Nature Communications. 4: 2172. PMID 23863894 DOI: 10.1038/ncomms3172  1
2013 Phadke SS, Feretzaki M, Heitman J. Unisexual reproduction enhances fungal competitiveness by promoting habitat exploration via hyphal growth and sporulation. Eukaryotic Cell. 12: 1155-9. PMID 23794511 DOI: 10.1128/EC.00147-13  1
2013 Calo S, Billmyre RB, Heitman J. Generators of phenotypic diversity in the evolution of pathogenic microorganisms. Plos Pathogens. 9: e1003181. PMID 23555239 DOI: 10.1371/journal.ppat.1003181  1
2013 Guerreiro MA, Springer DJ, Rodrigues JA, Rusche LN, Findley K, Heitman J, Fonseca A. Molecular and genetic evidence for a tetrapolar mating system in the basidiomycetous yeast Kwoniella mangrovensis and two novel sibling species. Eukaryotic Cell. 12: 746-60. PMID 23524993 DOI: 10.1128/EC.00065-13  1
2013 Ding C, Festa RA, Chen YL, Espart A, Palacios Ò, Espín J, Capdevila M, Atrian S, Heitman J, Thiele DJ. Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. Cell Host & Microbe. 13: 265-76. PMID 23498952 DOI: 10.1016/j.chom.2013.02.002  1
2013 Chen YL, Lehman VN, Averette AF, Perfect JR, Heitman J. Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans. Plos One. 8: e57672. PMID 23472097 DOI: 10.1371/journal.pone.0057672  1
2013 Chen YL, Lehman VN, Lewit Y, Averette AF, Heitman J. Calcineurin governs thermotolerance and virulence of Cryptococcus gattii. G3 (Bethesda, Md.). 3: 527-39. PMID 23450261 DOI: 10.1534/g3.112.004242  1
2013 Wang X, Darwiche S, Heitman J. Sex-induced silencing operates during opposite-sex and unisexual reproduction in Cryptococcus neoformans. Genetics. 193: 1163-74. PMID 23378067 DOI: 10.1534/genetics.113.149443  1
2013 Gioti A, Nystedt B, Li W, Xu J, Andersson A, Averette AF, Münch K, Wang X, Kappauf C, Kingsbury JM, Kraak B, Walker LA, Johansson HJ, Holm T, Lehtiö J, ... ... Heitman J, et al. Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis. Mbio. 4: e00572-12. PMID 23341551 DOI: 10.1128/mBio.00572-12  1
2013 Li W, Sullivan TD, Walton E, Averette AF, Sakthikumar S, Cuomo CA, Klein BS, Heitman J. Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis. Eukaryotic Cell. 12: 109-17. PMID 23143684 DOI: 10.1128/EC.00249-12  1
2013 Heitman J, Sun S, James TY. Evolution of fungal sexual reproduction. Mycologia. 105: 1-27. PMID 23099518 DOI: 10.3852/12-253  1
2013 Li W, Savelkoul E, Heitman J, Logsdon JM. Evolution of Meiosis, Recombination, and Sexual Reproduction in Eukaryotic Microbes Evolution of Virulence in Eukaryotic Microbes. 17-43. DOI: 10.1002/9781118308165.ch2  1
2012 Lee SC, Ristaino JB, Heitman J. Parallels in intercellular communication in oomycete and fungal pathogens of plants and humans. Plos Pathogens. 8: e1003028. PMID 23271965 DOI: 10.1371/journal.ppat.1003028  1
2012 Springer DJ, Phadke S, Billmyre B, Heitman J. Cryptococcus gattii, no longer an accidental pathogen? Current Fungal Infection Reports. 6: 245-256. PMID 23243480 DOI: 10.1007/s12281-012-0111-0  1
2012 Yang DH, Maeng S, Strain AK, Floyd A, Nielsen K, Heitman J, Bahn YS. Pleiotropic roles of the Msi1-like protein Msl1 in Cryptococcus neoformans. Eukaryotic Cell. 11: 1482-95. PMID 23042129 DOI: 10.1128/EC.00261-12  1
2012 Lee SC, Phadke S, Sun S, Heitman J. Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases. Eukaryotic Cell. 11: 1391-8. PMID 23002105 DOI: 10.1128/EC.00242-12  1
2012 Zhang J, Silao FG, Bigol UG, Bungay AA, Nicolas MG, Heitman J, Chen YL. Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. Plos One. 7: e44192. PMID 22952924 DOI: 10.1371/journal.pone.0044192  1
2012 Martinez DA, Oliver BG, Gräser Y, Goldberg JM, Li W, Martinez-Rossi NM, Monod M, Shelest E, Barton RC, Birch E, Brakhage AA, Chen Z, Gurr SJ, Heiman D, Heitman J, et al. Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. Mbio. 3: e00259-12. PMID 22951933 DOI: 10.1128/mBio.00259-12  1
2012 Sun S, Heitman J. Should Y stay or should Y go: the evolution of non-recombining sex chromosomes. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 34: 938-42. PMID 22948853 DOI: 10.1002/bies.201200064  1
2012 Wang X, Wang P, Sun S, Darwiche S, Idnurm A, Heitman J. Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans. Plos Genetics. 8: e1002885. PMID 22916030 DOI: 10.1371/journal.pgen.1002885  1
2012 Zhang J, Heitman J, Chen YL. Comparative analysis of calcineurin signaling between Candida dubliniensis and Candida albicans. Communicative & Integrative Biology. 5: 122-6. PMID 22808313 DOI: 10.4161/cib.18833  1
2012 Kingsbury JM, Heitman J, Pinnell SR. Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans. Plos One. 7: e39405. PMID 22792174 DOI: 10.1371/journal.pone.0039405  1
2012 Sun S, Hsueh YP, Heitman J. Gene conversion occurs within the mating-type locus of Cryptococcus neoformans during sexual reproduction. Plos Genetics. 8: e1002810. PMID 22792079 DOI: 10.1371/journal.pgen.1002810  1
2012 Floudas D, Binder M, Riley R, Barry K, Blanchette RA, Henrissat B, Martínez AT, Otillar R, Spatafora JW, Yadav JS, Aerts A, Benoit I, Boyd A, Carlson A, Copeland A, ... ... Heitman J, et al. The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes. Science (New York, N.Y.). 336: 1715-9. PMID 22745431 DOI: 10.1126/science.1221748  1
2012 Saunders CW, Scheynius A, Heitman J. Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases. Plos Pathogens. 8: e1002701. PMID 22737067 DOI: 10.1371/journal.ppat.1002701  1
2012 Chen YL, Konieczka JH, Springer DJ, Bowen SE, Zhang J, Silao FG, Bungay AA, Bigol UG, Nicolas MG, Abraham SN, Thompson DA, Regev A, Heitman J. Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata. G3 (Bethesda, Md.). 2: 675-91. PMID 22690377 DOI: 10.1534/g3.112.002279  1
2012 Singh-Babak SD, Babak T, Diezmann S, Hill JA, Xie JL, Chen YL, Poutanen SM, Rennie RP, Heitman J, Cowen LE. Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. Plos Pathogens. 8: e1002718. PMID 22615574 DOI: 10.1371/journal.ppat.1002718  1
2012 Geunes-Boyer S, Beers MF, Perfect JR, Heitman J, Wright JR. Surfactant protein D facilitates Cryptococcus neoformans infection. Infection and Immunity. 80: 2444-53. PMID 22547543 DOI: 10.1128/IAI.05613-11  1
2012 Lee SC, Heitman J. Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating. Eukaryotic Cell. 11: 783-94. PMID 22544906 DOI: 10.1128/EC.00066-12  1
2012 Li W, Averette AF, Desnos-Ollivier M, Ni M, Dromer F, Heitman J. Genetic Diversity and Genomic Plasticity of Cryptococcus neoformans AD Hybrid Strains. G3 (Bethesda, Md.). 2: 83-97. PMID 22384385 DOI: 10.1534/g3.111.001255  1
2012 Morrow CA, Lee IR, Chow EW, Ormerod KL, Goldinger A, Byrnes EJ, Nielsen K, Heitman J, Schirra HJ, Fraser JA. A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. Mbio. 3. PMID 22375073 DOI: 10.1128/mBio.00310-11  1
2012 Findley K, Sun S, Fraser JA, Hsueh YP, Averette AF, Li W, Dietrich FS, Heitman J. Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex. Plos Genetics. 8: e1002528. PMID 22359516 DOI: 10.1371/journal.pgen.1002528  1
2012 Stramer SL, Collins C, Nugent T, Wang X, Fuschino M, Heitman JW, Law J, Krysztof DE, Kiely N, Todd D, Vermeulen NM, Harrington K, Kamel H, Kelvin DJ, Busch MP, et al. Sensitive detection assays for influenza RNA do not reveal viremia in US blood donors. The Journal of Infectious Diseases. 205: 886-94. PMID 22293429 DOI: 10.1093/infdis/jir863  0.52
2012 Bastidas RJ, Shertz CA, Lee SC, Heitman J, Cardenas ME. Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor. Eukaryotic Cell. 11: 270-81. PMID 22210828 DOI: 10.1128/EC.05284-11  1
2012 Song MH, Lee JW, Kim MS, Yoon JK, White TC, Floyd A, Heitman J, Strain AK, Nielsen JN, Nielsen K, Bahn YS. A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. Eukaryotic Cell. 11: 53-67. PMID 22080454 DOI: 10.1128/EC.05236-11  1
2012 Wang X, Li W, Sun S, Kozubowski L, Lee SC, Feretzaki M, Heitman J. Know your enemy: how to build and vanquish a global fungal scourge. Mycopathologia. 173: 295-301. PMID 21997858 DOI: 10.1007/s11046-011-9484-9  1
2012 Kozubowski L, Heitman J. Profiling a killer, the development of Cryptococcus neoformans. Fems Microbiology Reviews. 36: 78-94. PMID 21658085 DOI: 10.1111/j.1574-6976.2011.00286.x  1
2011 Semighini CP, Averette AF, Perfect JR, Heitman J. Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. Plos Pathogens. 7: e1002364. PMID 22114551 DOI: 10.1371/journal.ppat.1002364  1
2011 Heitman J. Diversity in the realm of eukaryotic microbe form and function. Current Opinion in Microbiology. 14: 631-3. PMID 22074862 DOI: 10.1016/j.mib.2011.10.010  1
2011 Aboobakar EF, Wang X, Heitman J, Kozubowski L. The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. Eukaryotic Cell. 10: 1714-23. PMID 22002655 DOI: 10.1128/EC.05148-11  1
2011 Kozubowski L, Thompson JW, Cardenas ME, Moseley MA, Heitman J. Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. Plos One. 6: e25280. PMID 21984910 DOI: 10.1371/journal.pone.0025280  1
2011 Ni M, Feretzaki M, Sun S, Wang X, Heitman J. Sex in fungi. Annual Review of Genetics. 45: 405-30. PMID 21942368 DOI: 10.1146/annurev-genet-110410-132536  1
2011 Byrnes EJ, Li W, Ren P, Lewit Y, Voelz K, Fraser JA, Dietrich FS, May RC, Chaturvedi S, Chatuverdi S, Chaturvedi V, Chatuverdi V, Heitman J. A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients. Plos Pathogens. 7: e1002205. PMID 21909264 DOI: 10.1371/journal.ppat.1002205  1
2011 Sun S, Heitman J. Is sex necessary? Bmc Biology. 9: 56. PMID 21880159 DOI: 10.1186/1741-7007-9-56  1
2011 Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS, Kang HA. Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. Plos Pathogens. 7: e1002177. PMID 21852949 DOI: 10.1371/journal.ppat.1002177  1
2011 McCulloh RJ, Phillips R, Perfect JR, Byrnes EJ, Heitman J, Dufort E. Cryptococcus gattii genotype VGI infection in New England. The Pediatric Infectious Disease Journal. 30: 1111-4. PMID 21814154 DOI: 10.1097/INF.0b013e31822d14fd  1
2011 Kozubowski L, Aboobakar EF, Cardenas ME, Heitman J. Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. Eukaryotic Cell. 10: 1396-402. PMID 21724937 DOI: 10.1128/EC.05087-11  1
2011 Li CH, Cervantes M, Springer DJ, Boekhout T, Ruiz-Vazquez RM, Torres-Martinez SR, Heitman J, Lee SC. Sporangiospore size dimorphism is linked to virulence of Mucor circinelloides. Plos Pathogens. 7: e1002086. PMID 21698218 DOI: 10.1371/journal.ppat.1002086  1
2011 Byrnes EJ, Bartlett KH, Perfect JR, Heitman J. Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals. Microbes and Infection / Institut Pasteur. 13: 895-907. PMID 21684347 DOI: 10.1016/j.micinf.2011.05.009  1
2011 Chen YL, Brand A, Morrison EL, Silao FG, Bigol UG, Malbas FF, Nett JE, Andes DR, Solis NV, Filler SG, Averette A, Heitman J. Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. Eukaryotic Cell. 10: 803-19. PMID 21531874 DOI: 10.1128/EC.00310-10  1
2011 Heitman J. Microbial Pathogens in the Fungal Kingdom. Fungal Biology Reviews. 25: 48-60. PMID 21528015 DOI: 10.1016/j.fbr.2011.01.003  1
2011 D'Souza CA, Kronstad JW, Taylor G, Warren R, Yuen M, Hu G, Jung WH, Sham A, Kidd SE, Tangen K, Lee N, Zeilmaker T, Sawkins J, McVicker G, Shah S, ... ... Heitman J, et al. Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. Mbio. 2: e00342-10. PMID 21304167 DOI: 10.1128/mBio.00342-10  1
2011 Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, ... ... Heitman J, et al. Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biology. 12: R7. PMID 21247460 DOI: 10.1186/gb-2011-12-1-r7  1
2011 Sun S, Metin B, Findley K, Fonseca A, Heitman J. Validation of kwoniella heveanensis, teleomorph of the basidiomycetous yeast Cryptococcus heveanensis Mycotaxon. 116: 227-229. DOI: 10.5248/116.227  1
2011 Gladieux P, Byrnes EJ, Aguileta G, Fisher MC, Heitman J, Giraud T. Epidemiology and evolution of fungal pathogens in plants and animals Genetics and Evolution of Infectious Diseases. 59-132. DOI: 10.1016/B978-0-12-384890-1.00004-2  1
2010 Gryganskyi AP, Lee SC, Litvintseva AP, Smith ME, Bonito G, Porter TM, Anishchenko IM, Heitman J, Vilgalys R. Structure, function, and phylogeny of the mating locus in the Rhizopus oryzae complex. Plos One. 5: e15273. PMID 21151560 DOI: 10.1371/journal.pone.0015273  1
2010 Wang X, Hsueh YP, Li W, Floyd A, Skalsky R, Heitman J. Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. Genes & Development. 24: 2566-82. PMID 21078820 DOI: 10.1101/gad.1970910  1
2010 Janbon G, Maeng S, Yang DH, Ko YJ, Jung KW, Moyrand F, Floyd A, Heitman J, Bahn YS. Characterizing the role of RNA silencing components in Cryptococcus neoformans. Fungal Genetics and Biology : Fg & B. 47: 1070-80. PMID 21067947 DOI: 10.1016/j.fgb.2010.10.005  1
2010 Shertz CA, Bastidas RJ, Li W, Heitman J, Cardenas ME. Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. Bmc Genomics. 11: 510. PMID 20863387 DOI: 10.1186/1471-2164-11-510  1
2010 Xue C, Liu T, Chen L, Li W, Liu I, Kronstad JW, Seyfang A, Heitman J. Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. Mbio. 1. PMID 20689743 DOI: 10.1128/mBio.00084-10  1
2010 Heitman J. Evolution of eukaryotic microbial pathogens via covert sexual reproduction. Cell Host & Microbe. 8: 86-99. PMID 20638645 DOI: 10.1016/j.chom.2010.06.011  1
2010 Okagaki LH, Strain AK, Nielsen JN, Charlier C, Baltes NJ, Chrétien F, Heitman J, Dromer F, Nielsen K. Cryptococcal cell morphology affects host cell interactions and pathogenicity. Plos Pathogens. 6: e1000953. PMID 20585559 DOI: 10.1371/journal.ppat.1000953  1
2010 Kim MS, Ko YJ, Maeng S, Floyd A, Heitman J, Bahn YS. Comparative transcriptome analysis of the CO2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans. Genetics. 185: 1207-19. PMID 20516494 DOI: 10.1534/genetics.110.118315  1
2010 Lee SC, Ni M, Li W, Shertz C, Heitman J. The evolution of sex: a perspective from the fungal kingdom. Microbiology and Molecular Biology Reviews : Mmbr. 74: 298-340. PMID 20508251 DOI: 10.1128/MMBR.00005-10  1
2010 Metin B, Findley K, Heitman J. The mating type locus (MAT) and sexual reproduction of Cryptococcus heveanensis: insights into the evolution of sex and sex-determining chromosomal regions in fungi. Plos Genetics. 6: e1000961. PMID 20502678 DOI: 10.1371/journal.pgen.1000961  1
2010 Idnurm A, Heitman J. Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi. Microbiology (Reading, England). 156: 2393-407. PMID 20488877 DOI: 10.1099/mic.0.039222-0  1
2010 Lin X, Jackson JC, Feretzaki M, Xue C, Heitman J. Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans. Plos Genetics. 6: e1000953. PMID 20485569 DOI: 10.1371/journal.pgen.1000953  1
2010 Lee SC, Corradi N, Doan S, Dietrich FS, Keeling PJ, Heitman J. Evolution of the sex-related locus and genomic features shared in microsporidia and fungi. Plos One. 5: e10539. PMID 20479876 DOI: 10.1371/journal.pone.0010539  1
2010 Byrnes EJ, Li W, Lewit Y, Ma H, Voelz K, Ren P, Carter DA, Chaturvedi V, Bildfell RJ, May RC, Heitman J. Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. Plos Pathogens. 6: e1000850. PMID 20421942 DOI: 10.1371/journal.ppat.1000850  1
2010 Rodriguez-Carres M, Findley K, Sun S, Dietrich FS, Heitman J. Morphological and genomic characterization of Filobasidiella depauperata: a homothallic sibling species of the pathogenic cryptococcus species complex. Plos One. 5: e9620. PMID 20224779 DOI: 10.1371/journal.pone.0009620  1
2010 Geunes-Boyer S, Heitman J, Wright JR, Steinbach WJ. Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive. Medical Mycology. 48: 580-8. PMID 20141481 DOI: 10.3109/13693780903401682  1
2010 Maeng S, Ko YJ, Kim GB, Jung KW, Floyd A, Heitman J, Bahn YS. Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. Eukaryotic Cell. 9: 360-78. PMID 20097740 DOI: 10.1128/EC.00309-09  1
2010 Li W, Metin B, White TC, Heitman J. Organization and evolutionary trajectory of the mating type (MAT) locus in dermatophyte and dimorphic fungal pathogens. Eukaryotic Cell. 9: 46-58. PMID 19880755 DOI: 10.1128/EC.00259-09  0.44
2010 Reedy JL, Filler SG, Heitman J. Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. Fungal Genetics and Biology : Fg & B. 47: 107-16. PMID 19755168 DOI: 10.1016/j.fgb.2009.09.002  1
2010 Chen YL, Kozubowski L, Cardenas ME, Heitman J. On the roles of calcineurin in fungal growth and pathogenesis Current Fungal Infection Reports. 4: 244-255. DOI: 10.1007/s12281-010-0027-5  1
2009 Byrnes EJ, Heitman J. Cryptococcus gattii outbreak expands into the Northwestern United States with fatal consequences. F1000 Biology Reports. 1. PMID 20150950 DOI: 10.3410/B1-62  0.68
2009 Datta K, Bartlett KH, Baer R, Byrnes E, Galanis E, Heitman J, Hoang L, Leslie MJ, MacDougall L, Magill SS, Morshed MG, Marr KA. Spread of Cryptococcus gattii into Pacific Northwest region of the United States. Emerging Infectious Diseases. 15: 1185-91. PMID 19757550 DOI: 10.3201/eid1508.081384  1
2009 Velagapudi R, Hsueh YP, Geunes-Boyer S, Wright JR, Heitman J. Spores as infectious propagules of Cryptococcus neoformans. Infection and Immunity. 77: 4345-55. PMID 19620339 DOI: 10.1128/IAI.00542-09  1
2009 Ko YJ, Yu YM, Kim GB, Lee GW, Maeng PJ, Kim S, Floyd A, Heitman J, Bahn YS. Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryotic Cell. 8: 1197-217. PMID 19542307 DOI: 10.1128/EC.00120-09  1
2009 Byrnes EJ, Li W, Lewit Y, Perfect JR, Carter DA, Cox GM, Heitman J. First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen. Plos One. 4: e5851. PMID 19516904 DOI: 10.1371/journal.pone.0005851  0.68
2009 Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, ... ... Heitman J, et al. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature. 459: 657-62. PMID 19465905 DOI: 10.1038/nature08064  1
2009 Geunes-Boyer S, Oliver TN, Janbon G, Lodge JK, Heitman J, Perfect JR, Wright JR. Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival. Infection and Immunity. 77: 2783-94. PMID 19451250 DOI: 10.1128/IAI.00088-09  0.4
2009 Reedy JL, Floyd AM, Heitman J. Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex. Current Biology : Cb. 19: 891-9. PMID 19446455 DOI: 10.1016/j.cub.2009.04.058  1
2009 Sanz C, Rodríguez-Romero J, Idnurm A, Christie JM, Heitman J, Corrochano LM, Eslava AP. Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism. Proceedings of the National Academy of Sciences of the United States of America. 106: 7095-100. PMID 19380729 DOI: 10.1073/pnas.0900879106  1
2009 Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR, Heitman J, Cowen LE. Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. Current Biology : Cb. 19: 621-9. PMID 19327993 DOI: 10.1016/j.cub.2009.03.017  1
2009 Hsueh YP, Xue C, Heitman J. A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. The Embo Journal. 28: 1220-33. PMID 19322200 DOI: 10.1038/emboj.2009.68  1
2009 Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. Eukaryotic Cell. 8: 511-9. PMID 19252123 DOI: 10.1128/EC.00336-08  1
2009 Byrnes EJ, Bildfell RJ, Frank SA, Mitchell TG, Marr KA, Heitman J. Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States. The Journal of Infectious Diseases. 199: 1081-6. PMID 19220140 DOI: 10.1086/597306  1
2009 Bastidas RJ, Heitman J, Cardenas ME. The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. Plos Pathogens. 5: e1000294. PMID 19197361 DOI: 10.1371/journal.ppat.1000294  1
2009 Lin X, Patel S, Litvintseva AP, Floyd A, Mitchell TG, Heitman J. Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating. Plos Pathogens. 5: e1000283. PMID 19180236 DOI: 10.1371/journal.ppat.1000283  1
2009 Idnurm A, Walton FJ, Floyd A, Reedy JL, Heitman J. Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis. Eukaryotic Cell. 8: 315-26. PMID 19151325 DOI: 10.1128/EC.00375-08  1
2009 Findley K, Rodriguez-Carres M, Metin B, Kroiss J, Fonseca A, Vilgalys R, Heitman J. Phylogeny and phenotypic characterization of pathogenic Cryptococcus species and closely related saprobic taxa in the Tremellales. Eukaryotic Cell. 8: 353-61. PMID 19151324 DOI: 10.1128/EC.00373-08  1
2009 Byrnes EJ, Bildfell RJ, Dearing PL, Valentine BA, Heitman J. Cryptococcus gattii with bimorphic colony types in a dog in western Oregon: additional evidence for expansion of the Vancouver Island outbreak. Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 21: 133-6. PMID 19139515  1
2009 Bastidas RJ, Heitman J. Trimorphic stepping stones pave the way to fungal virulence. Proceedings of the National Academy of Sciences of the United States of America. 106: 351-2. PMID 19129500 DOI: 10.1073/pnas.0811994106  1
2009 Jain N, Li L, Hsueh YP, Guerrero A, Heitman J, Goldman DL, Fries BC. Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. Infection and Immunity. 77: 128-40. PMID 18955480 DOI: 10.1128/IAI.01079-08  1
2008 Lee SC, Corradi N, Byrnes EJ, Torres-Martinez S, Dietrich FS, Keeling PJ, Heitman J. Microsporidia evolved from ancestral sexual fungi. Current Biology : Cb. 18: 1675-9. PMID 18976912 DOI: 10.1016/j.cub.2008.09.030  1
2008 Hsueh YP, Heitman J. Orchestration of sexual reproduction and virulence by the fungal mating-type locus. Current Opinion in Microbiology. 11: 517-24. PMID 18935978 DOI: 10.1016/j.mib.2008.09.014  1
2008 Xue C, Hsueh YP, Heitman J. Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. Fems Microbiology Reviews. 32: 1010-32. PMID 18811658 DOI: 10.1111/j.1574-6976.2008.00131.x  1
2008 Singh N, Lortholary O, Dromer F, Alexander BD, Gupta KL, John GT, del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Munoz P, Limaye AP, Kalil AC, ... ... Heitman J, et al. Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings. Transplantation. 86: 647-51. PMID 18791444 DOI: 10.1097/TP.0b013e3181814e76  1
2008 Xue C, Hsueh YP, Chen L, Heitman J. The RGS protein Crg2 regulates both pheromone and cAMP signalling in Cryptococcus neoformans. Molecular Microbiology. 70: 379-95. PMID 18761692 DOI: 10.1111/j.1365-2958.2008.06417.x  1
2008 Hsueh YP, Fraser JA, Heitman J. Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans. Eukaryotic Cell. 7: 1847-55. PMID 18723606 DOI: 10.1128/EC.00271-08  1
2008 Bastidas RJ, Reedy JL, Morales-Johansson H, Heitman J, Cardenas ME. Signaling cascades as drug targets in model and pathogenic fungi. Current Opinion in Investigational Drugs (London, England : 2000). 9: 856-64. PMID 18666033  1
2008 Juvvadi PR, Fortwendel JR, Pinchai N, Perfect BZ, Heitman J, Steinbach WJ. Calcineurin localizes to the hyphal septum in Aspergillus fumigatus: implications for septum formation and conidiophore development. Eukaryotic Cell. 7: 1606-10. PMID 18606829 DOI: 10.1128/EC.00200-08  1
2008 Bui T, Lin X, Malik R, Heitman J, Carter D. Isolates of Cryptococcus neoformans from infected animals reveal genetic exchange in unisexual, alpha mating type populations. Eukaryotic Cell. 7: 1771-80. PMID 18552280 DOI: 10.1128/EC.00097-08  0.52
2008 Cramer RA, Perfect BZ, Pinchai N, Park S, Perlin DS, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryotic Cell. 7: 1085-97. PMID 18456861 DOI: 10.1128/EC.00086-08  0.4
2007 Reedy JL, Bastidas RJ, Heitman J. The virulence of human pathogenic fungi: notes from the South of France. Cell Host & Microbe. 2: 77-83. PMID 18005722 DOI: 10.1016/j.chom.2007.07.004  1
2007 Onyewu C, Eads E, Schell WA, Perfect JR, Ullmann Y, Kaufman G, Horwitz BA, Berdicevsky I, Heitman J. Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrobial Agents and Chemotherapy. 51: 3743-6. PMID 17664323 DOI: 10.1128/AAC.00492-07  1
2007 Hsueh YP, Xue C, Heitman J. G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. Molecular Biology of the Cell. 18: 3237-49. PMID 17581859 DOI: 10.1091/mbc.E07-02-0133  1
2007 Steinbach WJ, Reedy JL, Cramer RA, Perfect JR, Heitman J. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nature Reviews. Microbiology. 5: 418-30. PMID 17505522 DOI: 10.1038/nrmicro1680  1
2007 Yan Z, Hull CM, Sun S, Heitman J, Xu J. The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans. Current Genetics. 51: 187-95. PMID 17186242 DOI: 10.1007/s00294-006-0115-9  1
2006 Hsueh YP, Idnurm A, Heitman J. Recombination hotspots flank the Cryptococcus mating-type locus: implications for the evolution of a fungal sex chromosome. Plos Genetics. 2: e184. PMID 17083277 DOI: 10.1371/journal.pgen.0020184  1
2006 Onyewu C, Afshari NA, Heitman J. Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrobial Agents and Chemotherapy. 50: 3963-5. PMID 16923949 DOI: 10.1128/AAC.00393-06  1
2006 Reedy JL, Husain S, Ison M, Pruett TL, Singh N, Heitman J. Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. Antimicrobial Agents and Chemotherapy. 50: 1573-7. PMID 16569889 DOI: 10.1128/AAC.50.4.1573-1577.2006  1
2005 Blankenship JR, Heitman J. Calcineurin is required for Candida albicans to survive calcium stress in serum. Infection and Immunity. 73: 5767-74. PMID 16113294 DOI: 10.1128/IAI.73.9.5767-5774.2005  1
2005 Lin X, Hull CM, Heitman J. Sexual reproduction between partners of the same mating type in Cryptococcus neoformans. Nature. 434: 1017-21. PMID 15846346 DOI: 10.1038/nature03448  1
2005 Hull CM, Boily MJ, Heitman J. Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. Eukaryotic Cell. 4: 526-35. PMID 15755915 DOI: 10.1128/EC.4.3.526-535.2005  1
2005 Blankenship JR, Singh N, Alexander BD, Heitman J. Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. Journal of Clinical Microbiology. 43: 464-7. PMID 15635017 DOI: 10.1128/JCM.43.1.464-467.2005  1
2004 Onyewu C, Wormley FL, Perfect JR, Heitman J. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infection and Immunity. 72: 7330-3. PMID 15557662 DOI: 10.1128/IAI.72.12.7330-7333.2004  1
2004 Arévalo-Rodríguez M, Pan X, Boeke JD, Heitman J. FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation. Eukaryotic Cell. 3: 1287-96. PMID 15470257 DOI: 10.1128/EC.3.5.1287-1296.2004  1
2004 Yan Z, Hull CM, Heitman J, Sun S, Xu J. SXI1alpha controls uniparental mitochondrial inheritance in Cryptococcus neoformans. Current Biology : Cb. 14: R743-4. PMID 15380081 DOI: 10.1016/j.cub.2004.09.008  1
2004 Hull CM, Cox GM, Heitman J. The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans. Infection and Immunity. 72: 3643-5. PMID 15155676 DOI: 10.1128/IAI.72.6.3643-3645.2004  1
2004 Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 48: 1664-9. PMID 15105118 DOI: 10.1128/AAC.48.5.1664-1669.2004  1
2004 Idnurm A, Reedy JL, Nussbaum JC, Heitman J. Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. Eukaryotic Cell. 3: 420-9. PMID 15075272 DOI: 10.1128/EC.3.2.420-429.2004  1
2003 Young LY, Hull CM, Heitman J. Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. Antimicrobial Agents and Chemotherapy. 47: 2717-24. PMID 12936965 DOI: 10.1128/AAC.47.9.2717-2724.2003  1
2003 Blankenship JR, Wormley FL, Boyce MK, Schell WA, Filler SG, Perfect JR, Heitman J. Calcineurin is essential for Candida albicans survival in serum and virulence. Eukaryotic Cell. 2: 422-30. PMID 12796287 DOI: 10.1128/EC.2.3.422-430.2003  1
2003 Blankenship JR, Steinbach WJ, Perfect JR, Heitman J. Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs. Current Opinion in Investigational Drugs (London, England : 2000). 4: 192-9. PMID 12669381  1
2003 Onyewu C, Blankenship JR, Del Poeta M, Heitman J. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrobial Agents and Chemotherapy. 47: 956-64. PMID 12604527 DOI: 10.1128/AAC.47.3.956-964.2003  1
2002 Hull CM, Davidson RC, Heitman J. Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha. Genes & Development. 16: 3046-60. PMID 12464634 DOI: 10.1101/gad.1041402  1
2002 Hull CM, Heitman J. Fungal mating: Candida albicans flips a switch to get in the mood. Current Biology : Cb. 12: R782-4. PMID 12445405 DOI: 10.1016/S0960-9822(02)01293-9  1
2002 Hull CM, Heitman J. Genetics of Cryptococcus neoformans. Annual Review of Genetics. 36: 557-615. PMID 12429703 DOI: 10.1146/annurev.genet.36.052402.152652  1
2002 Davidson RC, Blankenship JR, Kraus PR, de Jesus Berrios M, Hull CM, D'Souza C, Wang P, Heitman J. A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology (Reading, England). 148: 2607-15. PMID 12177355  1
2002 Pan X, Heitman J. Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. Molecular and Cellular Biology. 22: 3981-93. PMID 12024012 DOI: 10.1128/MCB.22.12.3981-3993.2002  1
2002 Cruz MC, Goldstein AL, Blankenship JR, Del Poeta M, Davis D, Cardenas ME, Perfect JR, McCusker JH, Heitman J. Calcineurin is essential for survival during membrane stress in Candida albicans. The Embo Journal. 21: 546-59. PMID 11847103 DOI: 10.1093/emboj/21.4.546  1
2001 Cutler NS, Pan X, Heitman J, Cardenas ME. The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Molecular Biology of the Cell. 12: 4103-13. PMID 11739804  1
2000 Pan X, Harashima T, Heitman J. Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Current Opinion in Microbiology. 3: 567-72. PMID 11121775 DOI: 10.1016/S1369-5274(00)00142-9  1
2000 Lengeler KB, Davidson RC, D'souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J. Signal transduction cascades regulating fungal development and virulence. Microbiology and Molecular Biology Reviews : Mmbr. 64: 746-85. PMID 11104818 DOI: 10.1128/MMBR.64.4.746-785.2000  1
2000 Pan X, Heitman J. Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Molecular and Cellular Biology. 20: 8364-72. PMID 11046133 DOI: 10.1128/MCB.20.22.8364-8372.2000  1
2000 Görlach J, Fox DS, Cutler NS, Cox GM, Perfect JR, Heitman J. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. The Embo Journal. 19: 3618-29. PMID 10899116 DOI: 10.1093/emboj/19.14.3618  1
2000 Lorenz MC, Pan X, Harashima T, Cardenas ME, Xue Y, Hirsch JP, Heitman J. The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics. 154: 609-22. PMID 10655215  1
2000 Lorenz MC, Cutler NS, Heitman J. Characterization of alcohol-induced filamentous growth in Saccharomyces cerevisiae. Molecular Biology of the Cell. 11: 183-99. PMID 10637301  1
1999 Cardenas ME, Cutler NS, Lorenz MC, Di Como CJ, Heitman J. The TOR signaling cascade regulates gene expression in response to nutrients. Genes & Development. 13: 3271-9. PMID 10617575 DOI: 10.1101/gad.13.24.3271  1
1999 Cutler NS, Heitman J, Cardenas ME. TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. Molecular and Cellular Endocrinology. 155: 135-42. PMID 10580846 DOI: 10.1016/S0303-7207(99)00121-5  1
1999 Pan X, Heitman J. Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Molecular and Cellular Biology. 19: 4874-87. PMID 10373537  1
1998 Cardenas ME, Sanfridson A, Cutler NS, Heitman J. Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends in Biotechnology. 16: 427-33. PMID 9807840 DOI: 10.1016/S0167-7799(98)01239-6  1
1997 Muir RS, Flores H, Zinder ND, Model P, Soberon X, Heitman J. Temperature-sensitive mutants of the EcoRI endonuclease. Journal of Molecular Biology. 274: 722-37. PMID 9405154 DOI: 10.1006/jmbi.1997.1419  1
1997 Cutler NS, Heitman J, Cardenas ME. STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 272: 27671-7. PMID 9346907 DOI: 10.1074/jbc.272.44.27671  1
1991 Heitman J, Model P. SOS induction as an in vivo assay of enzyme-DNA interactions. Gene. 103: 1-9. PMID 1908806 DOI: 10.1016/0378-1119(91)90383-M  1
1990 Heitman J, Model P. Mutants of the EcoRI endonuclease with promiscuous substrate specificity implicate residues involved in substrate recognition. The Embo Journal. 9: 3369-78. PMID 2209548  1
1990 Heitman J, Model P. Substrate recognition by the EcoRI endonuclease. Proteins. 7: 185-97. PMID 2139225 DOI: 10.1002/prot.340070207  1
1989 Heitman J, Fulford W, Model P. Phage Trojan horses: a conditional expression system for lethal genes. Gene. 85: 193-7. PMID 2695397 DOI: 10.1016/0378-1119(89)90480-0  1
1989 Heitman J, Zinder ND, Model P. Repair of the Escherichia coli chromosome after in vivo scission by the EcoRI endonuclease. Proceedings of the National Academy of Sciences of the United States of America. 86: 2281-5. PMID 2648397  1
1987 Heitman J, Model P. Site-specific methylases induce the SOS DNA repair response in Escherichia coli. Journal of Bacteriology. 169: 3243-50. PMID 3036779  1
Show low-probability matches.