| Year |
Citation |
Score |
| 2023 |
Coelho FS, Gava SG, Andrade LF, Geraldo JA, Tavares NC, Lunkes FMN, Neves RH, Machado-Silva JR, Pierce RJ, Oliveira G, Mourão MM. coactivator associated arginine methyltransferase 1 (SmCARM1) effect on parasite reproduction. Frontiers in Microbiology. 14: 1079855. PMID 36910171 DOI: 10.3389/fmicb.2023.1079855 |
0.391 |
|
| 2022 |
Ghazy E, Abdelsalam M, Robaa D, Pierce RJ, Sippl W. Histone Deacetylase (HDAC) Inhibitors for the Treatment of Schistosomiasis. Pharmaceuticals (Basel, Switzerland). 15. PMID 35056137 DOI: 10.3390/ph15010080 |
0.449 |
|
| 2021 |
Marek M, Ramos-Morales E, Picchi-Constante GFA, Bayer T, Norström C, Herp D, Sales-Junior PA, Guerra-Slompo EP, Hausmann K, Chakrabarti A, Shaik TB, Merz A, Troesch E, Schmidtkunz K, Goldenberg S, ... Pierce RJ, et al. Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Reports. 37: 110129. PMID 34936867 DOI: 10.1016/j.celrep.2021.110129 |
0.436 |
|
| 2021 |
Pagliazzo L, Caby S, Lancelot J, Salomé-Desnoulez S, Saliou JM, Heimburg T, Chassat T, Cailliau K, Sippl W, Vicogne J, Pierce RJ. Histone deacetylase 8 interacts with the GTPase SmRho1 in Schistosoma mansoni. Plos Neglected Tropical Diseases. 15: e0009503. PMID 34843489 DOI: 10.1371/journal.pntd.0009503 |
0.774 |
|
| 2021 |
Ghazy E, Heimburg T, Lancelot J, Zeyen P, Schmidtkunz K, Truhn A, Darwish S, Simoben CV, Shaik TB, Erdmann F, Schmidt M, Robaa D, Romier C, Jung M, Pierce R, et al. Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis. European Journal of Medicinal Chemistry. 225: 113745. PMID 34392190 DOI: 10.1016/j.ejmech.2021.113745 |
0.772 |
|
| 2020 |
Ângelo de Souza L, Silva E Bastos M, de Melo Agripino J, Souza Onofre T, Apaza Calla LF, Heimburg T, Ghazy E, Bayer T, Ferraz da Silva VH, Dutra Ribeiro P, Licursi de Oliveira L, Costa Bressan G, de Almeida Lamêgo MR, Silva-Júnior A, de Souza Vasconcellos R, ... ... Pierce R, et al. Histone deacetylases inhibitors as new potential drugs against Leishmania braziliensis, the main causative agent of new world tegumentary leishmaniasis. Biochemical Pharmacology. 180: 114191. PMID 32777278 DOI: 10.1016/J.Bcp.2020.114191 |
0.46 |
|
| 2020 |
Coutinho Carneiro V, de Abreu da Silva IC, Amaral MS, Pereira ASA, Silveira GO, Pires DDS, Verjovski-Almeida S, Dekker FJ, Rotili D, Mai A, Lopes-Torres EJ, Robaa D, Sippl W, Pierce RJ, Borrello MT, et al. Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni. Plos Neglected Tropical Diseases. 14: e0008332. PMID 32609727 DOI: 10.1371/Journal.Pntd.0008332 |
0.787 |
|
| 2020 |
Kalinin DV, Jana SK, Pfafenrot M, Chakrabarti A, Melesina J, Shaik TB, Lancelot J, Pierce RJ, Sippl W, Romier C, Jung M, Holl R. Front Cover: Structure‐Based Design, Synthesis, and Biological Evaluation of Triazole‐Based smHDAC8 Inhibitors (ChemMedChem 7/2020) Chemmedchem. 15: 559-559. DOI: 10.1002/Cmdc.201000139 |
0.696 |
|
| 2019 |
Holl R, Kalinin DV, Jana SK, Pfafenrot M, Chakrabarti A, Melesina J, Shaik TB, Lancelot J, Pierce RJ, Sippl W, Romier C, Jung M. Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors. Chemmedchem. PMID 31816172 DOI: 10.1002/Cmdc.201900583 |
0.78 |
|
| 2019 |
Monaldi D, Rotili D, Lancelot J, Marek M, Wössner N, Lucidi A, Tomaselli D, Ramos-Morales E, Romier C, Pierce R, Mai A, Jung M. Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2). Journal of Medicinal Chemistry. PMID 31496251 DOI: 10.1021/Acs.Jmedchem.9B00638 |
0.784 |
|
| 2018 |
Pereira ASA, Amaral MS, Vasconcelos EJR, Pires DS, Asif H, daSilva LF, Morales-Vicente DA, Carneiro VC, Angeli CB, Palmisano G, Fantappie MR, Pierce RJ, Setubal JC, Verjovski-Almeida S. Inhibition of histone methyltransferase EZH2 in Schistosoma mansoni in vitro by GSK343 reduces egg laying and decreases the expression of genes implicated in DNA replication and noncoding RNA metabolism. Plos Neglected Tropical Diseases. 12: e0006873. PMID 30365505 DOI: 10.1371/Journal.Pntd.0006873 |
0.439 |
|
| 2018 |
Marek M, Shaik TB, Heimburg T, Chakrabarti A, Lancelot J, Ramos Morales E, Da Veiga C, Kalinin DV, Melesina J, Robaa D, Schmidtkunz K, Suzuki T, Holl R, Ennifar E, Pierce R, et al. Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants. Journal of Medicinal Chemistry. PMID 30347148 DOI: 10.2210/Pdb6Htt/Pdb |
0.783 |
|
| 2018 |
Bayer T, Chakrabarti A, Lancelot J, Shaik TB, Hausmann K, Melesina J, Schmidtkunz K, Marek M, Erdmann F, Schmidt M, Robaa D, Romier C, Pierce RJ, Jung M, Sippl W. Synthesis, crystallization studies and in vitro characterization of novel cinnamic acid derivatives as SmHDAC8 inhibitors for the treatment of Schistosomiasis. Chemmedchem. PMID 29806110 DOI: 10.1002/Cmdc.201800238 |
0.769 |
|
| 2018 |
Simoben CV, Robaa D, Chakrabarti A, Schmidtkunz K, Marek M, Lancelot J, Kannan S, Melesina J, Shaik TB, Pierce RJ, Romier C, Jung M, Sippl W. A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing. Molecules (Basel, Switzerland). 23. PMID 29498707 DOI: 10.3390/Molecules23030566 |
0.777 |
|
| 2018 |
Bayer T, Chakrabarti A, Lancelot J, Shaik TB, Hausmann K, Melesina J, Schmidtkunz K, Marek M, Erdmann F, Schmidt M, Robaa D, Romier C, Pierce RJ, Jung M, Sippl W. Front Cover: Synthesis, Crystallization Studies, and in vitro Characterization of Cinnamic Acid Derivatives as Sm
HDAC8 Inhibitors for the Treatment of Schistosomiasis (ChemMedChem 15/2018) Chemmedchem. 13: 1488-1488. DOI: 10.1002/Cmdc.201800494 |
0.724 |
|
| 2017 |
Caby S, Pagliazzo L, Lancelot J, Saliou JM, Bertheaume N, Pierce RJ, Roger E. Analysis of the interactome of Schistosoma mansoni histone deacetylase 8. Plos Neglected Tropical Diseases. 11: e0006089. PMID 29155817 DOI: 10.1371/Journal.Pntd.0006089 |
0.788 |
|
| 2017 |
Stenzel K, Chakrabarti A, Melesina J, Hansen FK, Lancelot J, Herkenhöhner S, Lungerich B, Marek M, Romier C, Pierce RJ, Sippl W, Jung M, Kurz T. Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni. Archiv Der Pharmazie. PMID 28639720 DOI: 10.1002/Ardp.201700096 |
0.783 |
|
| 2017 |
Scholte LLS, Mourão MM, Pais FS, Melesina J, Robaa D, Volpini AC, Sippl W, Pierce RJ, Oliveira G, Nahum LA. Evolutionary relationships among protein lysine deacetylases of parasites causing neglected diseases. Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases. PMID 28506839 DOI: 10.1016/J.Meegid.2017.05.011 |
0.421 |
|
| 2017 |
Anderson L, Gomes MR, daSilva LF, Pereira AD, Mourão MM, Romier C, Pierce R, Verjovski-Almeida S. Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni. Plos Neglected Tropical Diseases. 11: e0005539. PMID 28406899 DOI: 10.1371/Journal.Pntd.0005539 |
0.52 |
|
| 2016 |
Marek M, Shaik TB, Jung M, Sippl W, Pierce RJ, Romier C. Biologie Aujourd'Hui. 210: 311-320. PMID 28327287 DOI: 10.1051/Jbio/2017001 |
0.41 |
|
| 2016 |
Chua MJ, Arnold MS, Xu W, Lancelot J, Lamotte S, Späth GF, Prina E, Pierce RJ, Fairlie DP, Skinner-Adams TS, Andrews KT. Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth. International Journal For Parasitology. Drugs and Drug Resistance. 7: 42-50. PMID 28107750 DOI: 10.1016/J.Ijpddr.2016.12.005 |
0.771 |
|
| 2016 |
Marek M, Shaik TB, Duclaud S, Pierce RJ, Romier C. Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni. Methods in Molecular Biology (Clifton, N.J.). 1436: 109-18. PMID 27246211 DOI: 10.1007/978-1-4939-3667-0_8 |
0.361 |
|
| 2016 |
Cabezas-Cruz A, Alberdi P, Ayllón N, Valdés JJ, Pierce R, Villar M, de la Fuente J. Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis. Epigenetics. 11: 303-19. PMID 27019326 DOI: 10.1080/15592294.2016.1163460 |
0.473 |
|
| 2016 |
Heimburg T, Chakrabarti A, Lancelot J, Marek M, Melesina J, Hauser AT, Shaik TB, Duclaud S, Robaa D, Erdmann F, Schmidt M, Romier C, Pierce RJ, Jung M, Sippl W. Structure-Based Design and Synthesis of Novel Inhibitors targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. Journal of Medicinal Chemistry. PMID 26937828 DOI: 10.1021/Acs.Jmedchem.5B01478 |
0.791 |
|
| 2015 |
Melesina J, Robaa D, Pierce RJ, Romier C, Sippl W. Homology modeling of parasite histone deacetylases to guide the structure-based design of selective inhibitors. Journal of Molecular Graphics & Modelling. 62: 342-361. PMID 26595183 DOI: 10.1016/J.Jmgm.2015.10.006 |
0.422 |
|
| 2015 |
Cabezas-Cruz A, Valdés JJ, Lancelot J, Pierce RJ. Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni. Bmc Genomics. 16: 980. PMID 26584526 DOI: 10.1186/S12864-015-2144-6 |
0.672 |
|
| 2015 |
Chakrabarti A, Oehme I, Witt O, Oliveira G, Sippl W, Romier C, Pierce RJ, Jung M. HDAC8: a multifaceted target for therapeutic interventions. Trends in Pharmacological Sciences. 36: 481-92. PMID 26013035 DOI: 10.1016/J.Tips.2015.04.013 |
0.433 |
|
| 2015 |
Marek M, Oliveira G, Pierce RJ, Jung M, Sippl W, Romier C. Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives. Future Medicinal Chemistry. 7: 783-800. PMID 25996070 DOI: 10.4155/Fmc.15.25 |
0.406 |
|
| 2015 |
Lancelot J, Cabezas-Cruz A, Caby S, Marek M, Schultz J, Romier C, Sippl W, Jung M, Pierce RJ. Schistosome sirtuins as drug targets. Future Medicinal Chemistry. 7: 765-82. PMID 25996069 DOI: 10.4155/Fmc.15.24 |
0.751 |
|
| 2015 |
Schiedel M, Marek M, Lancelot J, Karaman B, Almlöf I, Schultz J, Sippl W, Pierce RJ, Romier C, Jung M. Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni. Journal of Biomolecular Screening. 20: 112-21. PMID 25325257 DOI: 10.1177/1087057114555307 |
0.769 |
|
| 2014 |
Cabezas-Cruz A, Lancelot J, Caby S, Oliveira G, Pierce RJ. Epigenetic control of gene function in schistosomes: a source of therapeutic targets? Frontiers in Genetics. 5: 317. PMID 25309576 DOI: 10.3389/Fgene.2014.00317 |
0.782 |
|
| 2014 |
Kannan S, Melesina J, Hauser AT, Chakrabarti A, Heimburg T, Schmidtkunz K, Walter A, Marek M, Pierce RJ, Romier C, Jung M, Sippl W. Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation. Journal of Chemical Information and Modeling. 54: 3005-19. PMID 25243797 DOI: 10.1021/Ci5004653 |
0.372 |
|
| 2014 |
Carneiro VC, de Abreu da Silva IC, Torres EJ, Caby S, Lancelot J, Vanderstraete M, Furdas SD, Jung M, Pierce RJ, Fantappié MR. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. Plos Pathogens. 10: e1004116. PMID 24809504 DOI: 10.1371/Journal.Ppat.1004116 |
0.776 |
|
| 2014 |
Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M. Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni. Journal of Molecular Biology. 426: 3442-53. PMID 24657767 DOI: 10.1016/J.Jmb.2014.03.007 |
0.802 |
|
| 2013 |
Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, ... Pierce RJ, et al. Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni Plos Pathogens. 9. PMID 24086136 DOI: 10.1371/Journal.Ppat.1003645 |
0.803 |
|
| 2013 |
Lancelot J, Caby S, Dubois-Abdesselem F, Vanderstraete M, Trolet J, Oliveira G, Bracher F, Jung M, Pierce RJ. Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets. Plos Neglected Tropical Diseases. 7: e2428. PMID 24069483 DOI: 10.1371/Journal.Pntd.0002428 |
0.77 |
|
| 2013 |
Fréville A, Cailliau-Maggio K, Pierrot C, Tellier G, Kalamou H, Lafitte S, Martoriati A, Pierce RJ, Bodart JF, Khalife J. Plasmodium falciparum encodes a conserved active inhibitor-2 for Protein Phosphatase type 1: perspectives for novel anti-plasmodial therapy. Bmc Biology. 11: 80. PMID 23837822 DOI: 10.1186/1741-7007-11-80 |
0.305 |
|
| 2012 |
Pierce RJ, Dubois-Abdesselem F, Lancelot J, Andrade L, Oliveira G. Targeting schistosome histone modifying enzymes for drug development. Current Pharmaceutical Design. 18: 3567-78. PMID 22607147 DOI: 10.2174/138161212801327248 |
0.794 |
|
| 2012 |
Anderson L, Pierce RJ, Verjovski-Almeida S. Schistosoma mansoni histones: from transcription to chromatin regulation; an in silico analysis. Molecular and Biochemical Parasitology. 183: 105-14. PMID 22414701 DOI: 10.1016/j.molbiopara.2012.03.001 |
0.439 |
|
| 2011 |
Pierce RJ, Dubois-Abdesselem F, Caby S, Trolet J, Lancelot J, Oger F, Bertheaume N, Roger E. Chromatin regulation in schistosomes and histone modifying enzymes as drug targets. Memorias Do Instituto Oswaldo Cruz. 106: 794-801. PMID 22124550 DOI: 10.1590/S0074-02762011000700003 |
0.816 |
|
| 2009 |
Dubois F, Caby S, Oger F, Cosseau C, Capron M, Grunau C, Dissous C, Pierce RJ. Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni. Molecular and Biochemical Parasitology. 168: 7-15. PMID 19538992 DOI: 10.1016/J.Molbiopara.2009.06.001 |
0.798 |
|
| 2009 |
Caby S, Pierce RJ. Quantitative chromatin immunoprecipitation (Q-ChIP) applied to Schistosoma mansoni. Molecular and Biochemical Parasitology. 166: 77-80. PMID 19428676 DOI: 10.1016/j.molbiopara.2009.02.014 |
0.333 |
|
| 2008 |
Oger F, Dubois F, Caby S, Noël C, Cornette J, Bertin B, Capron M, Pierce RJ. The class I histone deacetylases of the platyhelminth parasite Schistosoma mansoni. Biochemical and Biophysical Research Communications. 377: 1079-84. PMID 18977200 DOI: 10.1016/J.Bbrc.2008.10.090 |
0.785 |
|
| 2007 |
Daher W, Pierce R, Khalife J. Census, molecular characterization and developmental expression of Leucine-Rich-Repeat proteins in Plasmodium falciparum. Molecular and Biochemical Parasitology. 155: 161-6. PMID 17689674 DOI: 10.1016/J.Molbiopara.2007.07.001 |
0.382 |
|
| 2007 |
Duboucher C, Caby S, Chabé M, Gantois N, Delgado-Viscogliosi P, Pierce R, Capron M, Dei-Cas E, Viscogliosi E. [Human pulmonary trichomonoses]. Presse Medicale (Paris, France : 1983). 36: 835-9. PMID 17449372 DOI: 10.1016/J.Lpm.2006.12.001 |
0.328 |
|
| 2006 |
Oger F, Bertin B, Caby S, Dalia-Cornette J, Adams M, Vicogne J, Capron M, Pierce RJ. Molecular cloning and characterization of Schistosoma mansoni Ftz-F1 interacting protein-1 (SmFIP-1), a novel corepressor of the nuclear receptor SmFtz-F1. Molecular and Biochemical Parasitology. 148: 10-23. PMID 16574255 DOI: 10.1016/J.Molbiopara.2006.02.016 |
0.775 |
|
| 2006 |
Bertin B, Oger F, Cornette J, Caby S, Noël C, Capron M, Fantappie MR, Rumjanek FD, Pierce RJ. Schistosoma mansoni CBP/p300 has a conserved domain structure and interacts functionally with the nuclear receptor SmFtz-F1. Molecular and Biochemical Parasitology. 146: 180-91. PMID 16427147 DOI: 10.1016/J.Molbiopara.2005.12.006 |
0.808 |
|
| 2005 |
Bouton D, Escriva H, de Mendonça RL, Glineur C, Bertin B, Noël C, Robinson-Rechavi M, de Groot A, Cornette J, Laudet V, Pierce RJ. A conserved retinoid X receptor (RXR) from the mollusk Biomphalaria glabrata transactivates transcription in the presence of retinoids. Journal of Molecular Endocrinology. 34: 567-82. PMID 15821117 DOI: 10.1677/Jme.1.01766 |
0.67 |
|
| 2005 |
Bertin B, Caby S, Oger F, Sasorith S, Wurtz JM, Pierce RJ. The monomeric orphan nuclear receptor Schistosoma mansoni Ftz-F1 dimerizes specifically and functionally with the schistosome RXR homologue, SmRXR1. Biochemical and Biophysical Research Communications. 327: 1072-82. PMID 15652506 DOI: 10.1016/J.Bbrc.2004.12.101 |
0.769 |
|
| 2004 |
Bertin B, Sasorith S, Caby S, Oger F, Cornette J, Wurtz JM, Pierce RJ. Unique functional properties of a member of the Fushi Tarazu-Factor 1 family from Schistosoma mansoni. The Biochemical Journal. 382: 337-51. PMID 15104535 DOI: 10.1042/Bj20040489 |
0.778 |
|
| 2004 |
Pierce RJ, Bertin B, Capron A. [Schistosomes worm their way into the genomic era]. Medecine Sciences : M/S. 20: 271-2. PMID 15067569 DOI: 10.1051/Medsci/2004203271 |
0.578 |
|
| 2002 |
De Mendonça RL, Bouton D, Bertin B, Escriva H, Noël C, Vanacker JM, Cornette J, Laudet V, Pierce RJ. A functionally conserved member of the FTZ-F1 nuclear receptor family from Schistosoma mansoni. European Journal of Biochemistry. 269: 5700-11. PMID 12423370 DOI: 10.1046/J.1432-1033.2002.03287.X |
0.678 |
|
| 2000 |
Trottein F, Mollicone R, Fontaine J, de Mendonça R, Piller F, Pierce R, Oriol R, Capron M. Molecular cloning of a putative alpha3-fucosyltransferase from Schistosoma mansoni. Molecular and Biochemical Parasitology. 107: 279-87. PMID 10779604 DOI: 10.1016/S0166-6851(00)00213-9 |
0.304 |
|
| 1997 |
Escriva H, Safi R, Hänni C, Langlois M, Saumitou-Laprade P, Stehelin D, Capron A, Pierce R, Laudet V. Ligand binding was acquired during evolution of nuclear receptors Proceedings of the National Academy of Sciences of the United States of America. 94: 6803-6808. PMID 9192646 DOI: 10.1073/Pnas.94.13.6803 |
0.302 |
|
| 1996 |
Maiorino M, Roche C, Kiess M, Koenig K, Gawlik D, Matthes M, Naldini E, Pierce R, Flohé L. A selenium-containing phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoni. Febs Journal. 238: 838-844. PMID 8706688 DOI: 10.1111/J.1432-1033.1996.0838W.X |
0.328 |
|
| 1996 |
Capron A, Riveau G, Grzych JM, Boulanger D, Capron M, Pierce R. Development of a vaccine strategy against human and bovine schistosomiasis. Background and update. Memorias Do Instituto Oswaldo Cruz. 90: 235-40. PMID 8531664 DOI: 10.1590/S0074-02761995000200019 |
0.302 |
|
| 1982 |
Auriault C, Pierce R, Cesari IM, Capron A. Neutral protease activities at different developmental stages of Schistosoma mansoni in mammalian hosts. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 72: 377-84. PMID 6751680 DOI: 10.1016/0305-0491(82)90215-2 |
0.361 |
|
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