Julien Lancelot - Publications

Affiliations: 
Lille 2 
Area:
Schistosomiasis, Histone Deacetylase, Mansoni sirtuin

23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ghazy E, Heimburg T, Lancelot J, Zeyen P, Schmidtkunz K, Truhn A, Darwish S, Simoben CV, Shaik TB, Erdmann F, Schmidt M, Robaa D, Romier C, Jung M, Pierce R, et al. Synthesis, structure-activity relationships, cocrystallization and cellular characterization of novel smHDAC8 inhibitors for the treatment of schistosomiasis. European Journal of Medicinal Chemistry. 225: 113745. PMID 34392190 DOI: 10.1016/j.ejmech.2021.113745  1
2020 Coutinho Carneiro V, de Abreu da Silva IC, Amaral MS, Pereira ASA, Silveira GO, Pires DDS, Verjovski-Almeida S, Dekker FJ, Rotili D, Mai A, Lopes-Torres EJ, Robaa D, Sippl W, Pierce RJ, Borrello MT, ... ... Lancelot J, et al. Pharmacological inhibition of lysine-specific demethylase 1 (LSD1) induces global transcriptional deregulation and ultrastructural alterations that impair viability in Schistosoma mansoni. Plos Neglected Tropical Diseases. 14: e0008332. PMID 32609727 DOI: 10.1371/Journal.Pntd.0008332  1
2019 Holl R, Kalinin DV, Jana SK, Pfafenrot M, Chakrabarti A, Melesina J, Shaik TB, Lancelot J, Pierce RJ, Sippl W, Romier C, Jung M. Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors. Chemmedchem. PMID 31816172 DOI: 10.1002/Cmdc.201900583  1
2019 Monaldi D, Rotili D, Lancelot J, Marek M, Wössner N, Lucidi A, Tomaselli D, Ramos-Morales E, Romier C, Pierce R, Mai A, Jung M. Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma Mansoni (SmSirt2). Journal of Medicinal Chemistry. PMID 31496251 DOI: 10.1021/Acs.Jmedchem.9B00638  1
2018 Marek M, Shaik TB, Heimburg T, Chakrabarti A, Lancelot J, Ramos Morales E, Da Veiga C, Kalinin DV, Melesina J, Robaa D, Schmidtkunz K, Suzuki T, Holl R, Ennifar E, Pierce R, et al. Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants. Journal of Medicinal Chemistry. PMID 30347148 DOI: 10.2210/Pdb6Htt/Pdb  1
2018 Bayer T, Chakrabarti A, Lancelot J, Shaik TB, Hausmann K, Melesina J, Schmidtkunz K, Marek M, Erdmann F, Schmidt M, Robaa D, Romier C, Pierce RJ, Jung M, Sippl W. Synthesis, crystallization studies and in vitro characterization of novel cinnamic acid derivatives as SmHDAC8 inhibitors for the treatment of Schistosomiasis. Chemmedchem. PMID 29806110 DOI: 10.1002/Cmdc.201800238  1
2018 Simoben CV, Robaa D, Chakrabarti A, Schmidtkunz K, Marek M, Lancelot J, Kannan S, Melesina J, Shaik TB, Pierce RJ, Romier C, Jung M, Sippl W. A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing. Molecules (Basel, Switzerland). 23. PMID 29498707 DOI: 10.3390/Molecules23030566  1
2017 Caby S, Pagliazzo L, Lancelot J, Saliou JM, Bertheaume N, Pierce RJ, Roger E. Analysis of the interactome of Schistosoma mansoni histone deacetylase 8. Plos Neglected Tropical Diseases. 11: e0006089. PMID 29155817 DOI: 10.1371/Journal.Pntd.0006089  1
2017 Stenzel K, Chakrabarti A, Melesina J, Hansen FK, Lancelot J, Herkenhöhner S, Lungerich B, Marek M, Romier C, Pierce RJ, Sippl W, Jung M, Kurz T. Isophthalic Acid-Based HDAC Inhibitors as Potent Inhibitors of HDAC8 from Schistosoma mansoni. Archiv Der Pharmazie. PMID 28639720 DOI: 10.1002/Ardp.201700096  1
2016 Chua MJ, Arnold MS, Xu W, Lancelot J, Lamotte S, Späth GF, Prina E, Pierce RJ, Fairlie DP, Skinner-Adams TS, Andrews KT. Effect of clinically approved HDAC inhibitors on Plasmodium, Leishmania and Schistosoma parasite growth. International Journal For Parasitology. Drugs and Drug Resistance. 7: 42-50. PMID 28107750 DOI: 10.1016/J.Ijpddr.2016.12.005  1
2016 Heimburg T, Chakrabarti A, Lancelot J, Marek M, Melesina J, Hauser AT, Shaik TB, Duclaud S, Robaa D, Erdmann F, Schmidt M, Romier C, Pierce RJ, Jung M, Sippl W. Structure-Based Design and Synthesis of Novel Inhibitors targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis. Journal of Medicinal Chemistry. PMID 26937828 DOI: 10.1021/Acs.Jmedchem.5B01478  1
2015 Cabezas-Cruz A, Valdés JJ, Lancelot J, Pierce RJ. Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni. Bmc Genomics. 16: 980. PMID 26584526 DOI: 10.1186/S12864-015-2144-6  1
2015 Lancelot J, Cabezas-Cruz A, Caby S, Marek M, Schultz J, Romier C, Sippl W, Jung M, Pierce RJ. Schistosome sirtuins as drug targets. Future Medicinal Chemistry. 7: 765-82. PMID 25996069 DOI: 10.4155/Fmc.15.24  1
2015 Schiedel M, Marek M, Lancelot J, Karaman B, Almlöf I, Schultz J, Sippl W, Pierce RJ, Romier C, Jung M. Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni. Journal of Biomolecular Screening. 20: 112-21. PMID 25325257 DOI: 10.1177/1087057114555307  1
2014 Morel M, Vanderstraete M, Cailliau K, Lescuyer A, Lancelot J, Dissous C. Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis. International Journal For Parasitology. Drugs and Drug Resistance. 4: 256-66. PMID 25516836 DOI: 10.1016/J.Ijpddr.2014.09.004  1
2014 Cabezas-Cruz A, Lancelot J, Caby S, Oliveira G, Pierce RJ. Epigenetic control of gene function in schistosomes: a source of therapeutic targets? Frontiers in Genetics. 5: 317. PMID 25309576 DOI: 10.3389/Fgene.2014.00317  1
2014 Carneiro VC, de Abreu da Silva IC, Torres EJ, Caby S, Lancelot J, Vanderstraete M, Furdas SD, Jung M, Pierce RJ, Fantappié MR. Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis. Plos Pathogens. 10: e1004116. PMID 24809504 DOI: 10.1371/Journal.Ppat.1004116  1
2014 Stolfa DA, Marek M, Lancelot J, Hauser AT, Walter A, Leproult E, Melesina J, Rumpf T, Wurtz JM, Cavarelli J, Sippl W, Pierce RJ, Romier C, Jung M. Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni. Journal of Molecular Biology. 426: 3442-53. PMID 24657767 DOI: 10.1016/J.Jmb.2014.03.007  1
2013 Marek M, Kannan S, Hauser AT, Moraes Mourão M, Caby S, Cura V, Stolfa DA, Schmidtkunz K, Lancelot J, Andrade L, Renaud JP, Oliveira G, Sippl W, Jung M, Cavarelli J, et al. Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni Plos Pathogens. 9. PMID 24086136 DOI: 10.1371/Journal.Ppat.1003645  1
2013 Lancelot J, Caby S, Dubois-Abdesselem F, Vanderstraete M, Trolet J, Oliveira G, Bracher F, Jung M, Pierce RJ. Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets. Plos Neglected Tropical Diseases. 7: e2428. PMID 24069483 DOI: 10.1371/Journal.Pntd.0002428  1
2013 Vanderstraete M, Gouignard N, Cailliau K, Morel M, Lancelot J, Bodart JF, Dissous C. Dual targeting of insulin and venus kinase Receptors of Schistosoma mansoni for novel anti-schistosome therapy. Plos Neglected Tropical Diseases. 7: e2226. PMID 23696913 DOI: 10.1371/Journal.Pntd.0002226  1
2012 Pierce RJ, Dubois-Abdesselem F, Lancelot J, Andrade L, Oliveira G. Targeting schistosome histone modifying enzymes for drug development. Current Pharmaceutical Design. 18: 3567-78. PMID 22607147 DOI: 10.2174/138161212801327248  1
2011 Pierce RJ, Dubois-Abdesselem F, Caby S, Trolet J, Lancelot J, Oger F, Bertheaume N, Roger E. Chromatin regulation in schistosomes and histone modifying enzymes as drug targets. Memorias Do Instituto Oswaldo Cruz. 106: 794-801. PMID 22124550 DOI: 10.1590/S0074-02762011000700003  1
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