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Damien J. Downes - Publications

Affiliations: 
2010-2015 Department of Plant Pathology; Genetics Graduate Program Kansas State University, Manhattan, KS, United States 
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23 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Kassouf MT, Francis HS, Gosden M, Suciu MC, Downes DJ, Harrold C, Larke M, Oudelaar M, Cornell L, Blayney J, Telenius J, Xella B, Shen Y, Sousos N, Sharpe JA, et al. The α-globin super-enhancer acts in an orientation-dependent manner. Nature Communications. 16: 1033. PMID 39863595 DOI: 10.1038/s41467-025-56380-1  0.325
2022 Truch J, Downes DJ, Scott C, Gür ER, Telenius JM, Repapi E, Schwessinger R, Gosden M, Brown JM, Taylor S, Cheong PL, Hughes JR, Higgs DR, Gibbons RJ. The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin. Nature Communications. 13: 3485. PMID 35710802 DOI: 10.1038/s41467-022-31194-7  0.355
2022 Downes DJ, Hughes JR. Natural and Experimental Rewiring of Gene Regulatory Regions. Annual Review of Genomics and Human Genetics. PMID 35472292 DOI: 10.1146/annurev-genom-112921-010715  0.396
2022 Owens DDG, Anselmi G, Oudelaar AM, Downes DJ, Cavallo A, Harman JR, Schwessinger R, Bucakci A, Greder L, de Ornellas S, Jeziorska D, Telenius J, Hughes JR, de Bruijn MFTR. Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development. Nature Communications. 13: 773. PMID 35140205 DOI: 10.1038/s41467-022-28376-8  0.365
2021 King AJ, Songdej D, Downes DJ, Beagrie RA, Liu S, Buckley M, Hua P, Suciu MC, Marieke Oudelaar A, Hanssen LLP, Jeziorska D, Roberts N, Carpenter SJ, Francis H, Telenius J, et al. Reactivation of a developmentally silenced embryonic globin gene. Nature Communications. 12: 4439. PMID 34290235 DOI: 10.1038/s41467-021-24402-3  0.374
2021 Bozhilov YK, Downes DJ, Telenius J, Marieke Oudelaar A, Olivier EN, Mountford JC, Hughes JR, Gibbons RJ, Higgs DR. A gain-of-function single nucleotide variant creates a new promoter which acts as an orientation-dependent enhancer-blocker. Nature Communications. 12: 3806. PMID 34155213 DOI: 10.1038/s41467-021-23980-6  0.359
2021 Steyer JT, Downes DJ, Hunter CC, Migeon PA, Todd RB. Duplication and Functional Divergence of Branched-Chain Amino Acid Biosynthesis Genes in Aspergillus nidulans. Mbio. e0076821. PMID 34154419 DOI: 10.1128/mBio.00768-21  0.57
2021 Hua P, Badat M, Hanssen LLP, Hentges LD, Crump N, Downes DJ, Jeziorska DM, Oudelaar AM, Schwessinger R, Taylor S, Milne TA, Hughes JR, Higgs DR, Davies JOJ. Defining genome architecture at base-pair resolution. Nature. PMID 34108683 DOI: 10.1038/s41586-021-03639-4  0.368
2021 Larke MSC, Schwessinger R, Nojima T, Telenius J, Beagrie RA, Downes DJ, Oudelaar AM, Truch J, Graham B, Bender MA, Proudfoot NJ, Higgs DR, Hughes JR. Enhancers predominantly regulate gene expression during differentiation via transcription initiation. Molecular Cell. PMID 33539786 DOI: 10.1016/j.molcel.2021.01.002  0.432
2021 Bejjani F, Tolza C, Boulanger M, Downes D, Romero R, Maqbool MA, Zine El Aabidine A, Andrau JC, Lebre S, Brehelin L, Parrinello H, Rohmer M, Kaoma T, Vallar L, Hughes JR, et al. Fra-1 regulates its target genes via binding to remote enhancers without exerting major control on chromatin architecture in triple negative breast cancers. Nucleic Acids Research. PMID 33533919 DOI: 10.1093/nar/gkab053  0.385
2020 Olijnik AA, Roy NBA, Scott C, Marsh JA, Brown J, Lauschke K, Ask K, Roberts N, Downes DJ, Brolih S, Johnson E, Xella B, Proven M, Hipkiss R, Ryan K, et al. Genetic and functional insights into CDA-I prevalence and pathogenesis. Journal of Medical Genetics. PMID 32518175 DOI: 10.1136/Jmedgenet-2020-106880  0.421
2020 Gillespie MA, Palii CG, Sanchez-Taltavull D, Shannon P, Longabaugh WJR, Downes DJ, Sivaraman K, Espinoza HM, Hughes JR, Price ND, Perkins TJ, Ranish JA, Brand M. Absolute Quantification of Transcription Factors Reveals Principles of Gene Regulation in Erythropoiesis. Molecular Cell. PMID 32330456 DOI: 10.1016/J.Molcel.2020.03.031  0.44
2019 Godfrey L, Crump NT, Thorne R, Lau IJ, Repapi E, Dimou D, Smith AL, Harman JR, Telenius JM, Oudelaar AM, Downes DJ, Vyas P, Hughes JR, Milne TA. DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation. Nature Communications. 10: 2803. PMID 31243293 DOI: 10.1038/S41467-019-10844-3  0.4
2018 Oudelaar AM, Davies JOJ, Hanssen LLP, Telenius JM, Schwessinger R, Liu Y, Brown JM, Downes DJ, Chiariello AM, Bianco S, Nicodemi M, Buckle VJ, Dekker J, Higgs DR, Hughes JR. Single-allele chromatin interactions identify regulatory hubs in dynamic compartmentalized domains. Nature Genetics. PMID 30374068 DOI: 10.1038/S41588-018-0253-2  0.37
2018 Schäfer A, Mekker B, Mallick M, Vastolo V, Karaulanov E, Sebastian D, von der Lippen C, Epe B, Downes DJ, Scholz C, Niehrs C. Impaired DNA demethylation of C/EBP sites causes premature aging. Genes & Development. PMID 29884649 DOI: 10.1101/Gad.311969.118  0.324
2017 Hanssen LLP, Kassouf MT, Oudelaar AM, Biggs D, Preece C, Downes DJ, Gosden M, Sharpe JA, Sloane-Stanley JA, Hughes JR, Davies B, Higgs DR. Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo. Nature Cell Biology. PMID 28737770 DOI: 10.1038/Ncb3573  0.395
2017 Simon CS, Downes DJ, Gosden ME, Telenius J, Higgs DR, Hughes JR, Costello I, Bikoff EK, Robertson EJ. Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo. Development (Cambridge, England). PMID 28174238 DOI: 10.1242/Dev.147322  0.458
2015 Benoit I, Zhou M, Vivas Duarte A, Downes DJ, Todd RB, Kloezen W, Post H, Heck AJ, Maarten Altelaar AF, de Vries RP. Spatial differentiation of gene expression in Aspergillus niger colony grown for sugar beet pulp utilization. Scientific Reports. 5: 13592. PMID 26314379 DOI: 10.1038/Srep13592  0.721
2015 Benoit I, Zhou M, Vivas Duarte A, Downes DJ, Todd RB, Kloezen W, Post H, Heck AJR, Maarten Altelaar AF, De Vries RP. Spatial differentiation of gene expression in Aspergillus Niger colony grown for sugar beet pulp utilization Scientific Reports. 5. DOI: 10.1038/srep13592  0.687
2014 Downes DJ, Chonofsky M, Tan K, Pfannenstiel BT, Reck-Peterson SL, Todd RB. Characterization of the mutagenic spectrum of 4-nitroquinoline 1-oxide (4-NQO) in Aspergillus nidulans by whole genome sequencing. G3 (Bethesda, Md.). 4: 2483-92. PMID 25352541 DOI: 10.1534/G3.114.014712  0.672
2014 Downes DJ, Davis MA, Wong KH, Kreutzberger SD, Hynes MJ, Todd RB. Dual DNA binding and coactivator functions of Aspergillus nidulans TamA, a Zn(II)2Cys6 transcription factor. Molecular Microbiology. 92: 1198-211. PMID 24750216 DOI: 10.1111/Mmi.12620  0.712
2014 Hunter CC, Siebert KS, Downes DJ, Wong KH, Kreutzberger SD, Fraser JA, Clarke DF, Hynes MJ, Davis MA, Todd RB. Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA. Eukaryotic Cell. 13: 527-38. PMID 24562911 DOI: 10.1128/Ec.00040-14  0.664
2013 Downes DJ, Davis MA, Kreutzberger SD, Taig BL, Todd RB. Regulation of the NADP-glutamate dehydrogenase gene gdhA in Aspergillus nidulans by the Zn(II)2Cys6 transcription factor LeuB. Microbiology (Reading, England). 159: 2467-80. PMID 24025604 DOI: 10.1099/Mic.0.071514-0  0.779
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