Ian Holt, Ph.D. - Publications

Affiliations: 
Dunn Nutrition Unit MRC National Institute for Medical Research, London, England, United Kingdom 
Area:
Mitochondrial biogenesis

73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Cluett TJ, Akman G, Reyes A, Kazak L, Mitchell A, Wood SR, Spinazzola A, Spelbrink JN, Holt IJ. Transcript availability dictates the balance between strand-asynchronous and strand-coupled mitochondrial DNA replication. Nucleic Acids Research. PMID 30239839 DOI: 10.1093/nar/gky852  0.52
2016 Liyanage SU, Coyaud E, Laurent EM, Hurren R, Maclean N, Wood SR, Kazak L, Shamas-Din A, Holt I, Raught B, Schimmer A. Characterizing the mitochondrial DNA polymerase gamma interactome by BioID identifies Ruvbl2 localizes to the mitochondria. Mitochondrion. PMID 27845271 DOI: 10.1016/j.mito.2016.11.001  0.52
2016 Akman G, Desai R, Bailey LJ, Yasukawa T, Dalla Rosa I, Durigon R, Holmes JB, Moss CF, Mennuni M, Houlden H, Crouch RJ, Hanna MG, Pitceathly RD, Spinazzola A, Holt IJ. Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402764 DOI: 10.1073/pnas.1600537113  0.52
2016 Dalla Rosa I, Cámara Y, Durigon R, Moss CF, Vidoni S, Akman G, Hunt L, Johnson MA, Grocott S, Wang L, Thorburn DR, Hirano M, Poulton J, Taylor RW, Elgar G, ... ... Holt IJ, et al. MPV17 Loss Causes Deoxynucleotide Insufficiency and Slow DNA Replication in Mitochondria. Plos Genetics. 12: e1005779. PMID 26760297 DOI: 10.1371/journal.pgen.1005779  0.52
2016 Holt IJ, Kazak L, Reyes A, Wood SR. Analysis of Replicating Mitochondrial DNA by In Organello Labeling and Two-Dimensional Agarose Gel Electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 1351: 95-113. PMID 26530677 DOI: 10.1007/978-1-4939-3040-1_8  0.52
2015 Gerhold JM, Cansiz-Arda Ş, Lõhmus M, Engberg O, Reyes A, van Rennes H, Sanz A, Holt IJ, Cooper HM, Spelbrink JN. Corrigendum: Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure. Scientific Reports. 5: 17119. PMID 26656719 DOI: 10.1038/srep17119  0.52
2015 Gerhold JM, Cansiz-Arda Ş, Lõhmus M, Engberg O, Reyes A, van Rennes H, Sanz A, Holt IJ, Cooper HM, Spelbrink JN. Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure. Scientific Reports. 5: 15292. PMID 26478270 DOI: 10.1038/srep15292  0.52
2015 Holmes JB, Akman G, Wood SR, Sakhuja K, Cerritelli SM, Moss C, Bowmaker MR, Jacobs HT, Crouch RJ, Holt IJ. Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication. Proceedings of the National Academy of Sciences of the United States of America. PMID 26162680 DOI: 10.1073/pnas.1503653112  0.52
2015 Litwin TR, Solà M, Holt IJ, Neuman KC. A robust assay to measure DNA topology-dependent protein binding affinity. Nucleic Acids Research. 43: e43. PMID 25552413 DOI: 10.1093/nar/gku1381  0.52
2015 Humphrey EL, Lacey E, Le LT, Feng L, Sciandra F, Morris CR, Hewitt JE, Holt I, Brancaccio A, Barresi R, Sewry CA, Brown SC, Morris GE. A new monoclonal antibody DAG-6F4 against human alpha-dystroglycan reveals reduced core protein in some, but not all, dystroglycanopathy patients. Neuromuscular Disorders : Nmd. 25: 32-42. PMID 25387694 DOI: 10.1016/j.nmd.2014.09.005  0.52
2014 Holt IJ, Jacobs HT. Unique features of DNA replication in mitochondria: a functional and evolutionary perspective. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 1024-31. PMID 25220172 DOI: 10.1002/bies.201400052  0.52
2014 Dalla Rosa I, Durigon R, Pearce SF, Rorbach J, Hirst EM, Vidoni S, Reyes A, Brea-Calvo G, Minczuk M, Woellhaf MW, Herrmann JM, Huynen MA, Holt IJ, Spinazzola A. MPV17L2 is required for ribosome assembly in mitochondria. Nucleic Acids Research. 42: 8500-15. PMID 24948607 DOI: 10.1093/nar/gku513  0.52
2014 King SJ, Nowak K, Suryavanshi N, Holt I, Shanahan CM, Ridley AJ. Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration. Cytoskeleton (Hoboken, N.J.). 71: 423-34. PMID 24931616 DOI: 10.1002/cm.21182  0.52
2014 Holt IJ, Speijer D, Kirkwood TB. The road to rack and ruin: selecting deleterious mitochondrial DNA variants. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369: 20130451. PMID 24864317 DOI: 10.1098/rstb.2013.0451  0.52
2014 Johnson MA, Vidoni S, Durigon R, Pearce SF, Rorbach J, He J, Brea-Calvo G, Minczuk M, Reyes A, Holt IJ, Spinazzola A. Amino acid starvation has opposite effects on mitochondrial and cytosolic protein synthesis. Plos One. 9: e93597. PMID 24718614 DOI: 10.1371/journal.pone.0093597  0.52
2014 Duong NT, Morris GE, Lam le T, Zhang Q, Sewry CA, Shanahan CM, Holt I. Nesprins: tissue-specific expression of epsilon and other short isoforms. Plos One. 9: e94380. PMID 24718612 DOI: 10.1371/journal.pone.0094380  0.52
2014 Carpentier C, Ghanem D, Fernandez-Gomez FJ, Jumeau F, Philippe JV, Freyermuth F, Labudeck A, Eddarkaoui S, Dhaenens CM, Holt I, Behm-Ansmant I, Marmier-Gourrier N, Branlant C, Charlet-Berguerand N, Marie J, et al. Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2. Biochimica Et Biophysica Acta. 1842: 654-64. PMID 24440524 DOI: 10.1016/j.bbadis.2014.01.004  0.52
2014 Ketley A, Chen CZ, Li X, Arya S, Robinson TE, Granados-Riveron J, Udosen I, Morris GE, Holt I, Furling D, Chaouch S, Haworth B, Southall N, Shinn P, Zheng W, et al. High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic dystrophy cell lines. Human Molecular Genetics. 23: 1551-62. PMID 24179176 DOI: 10.1093/hmg/ddt542  0.52
2013 García-Gómez S, Reyes A, Martínez-Jiménez MI, Chocrón ES, Mourón S, Terrados G, Powell C, Salido E, Méndez J, Holt IJ, Blanco L. PrimPol, an archaic primase/polymerase operating in human cells. Molecular Cell. 52: 541-53. PMID 24207056 DOI: 10.1016/j.molcel.2013.09.025  0.52
2013 Jõers P, Lewis SC, Fukuoh A, Parhiala M, Ellilä S, Holt IJ, Jacobs HT. Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis. Plos Genetics. 9: e1003800. PMID 24068965 DOI: 10.1371/journal.pgen.1003800  0.52
2013 Holt I, Gestmann I, Wright AC. Alignment of muscle precursor cells on the vertical edges of thick carbon nanotube films. Materials Science & Engineering. C, Materials For Biological Applications. 33: 4274-9. PMID 23910343 DOI: 10.1016/j.msec.2013.06.017  0.52
2013 Kazak L, Reyes A, He J, Wood SR, Brea-Calvo G, Holen TT, Holt IJ. A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. Plos One. 8: e62340. PMID 23675412 DOI: 10.1371/journal.pone.0062340  0.52
2013 Reyes A, Kazak L, Wood SR, Yasukawa T, Jacobs HT, Holt IJ. Mitochondrial DNA replication proceeds via a 'bootlace' mechanism involving the incorporation of processed transcripts. Nucleic Acids Research. 41: 5837-50. PMID 23595151 DOI: 10.1093/nar/gkt196  0.52
2013 Kazak L, Reyes A, Duncan AL, Rorbach J, Wood SR, Brea-Calvo G, Gammage PA, Robinson AJ, Minczuk M, Holt IJ. Alternative translation initiation augments the human mitochondrial proteome. Nucleic Acids Research. 41: 2354-69. PMID 23275553 DOI: 10.1093/nar/gks1347  0.52
2013 Tomé S, Simard JP, Slean MM, Holt I, Morris GE, Wojciechowicz K, te Riele H, Pearson CE. Tissue-specific mismatch repair protein expression: MSH3 is higher than MSH6 in multiple mouse tissues. Dna Repair. 12: 46-52. PMID 23228367 DOI: 10.1016/j.dnarep.2012.10.006  0.52
2012 Holt IJ, Reyes A. Human mitochondrial DNA replication. Cold Spring Harbor Perspectives in Biology. 4. PMID 23143808 DOI: 10.1101/cshperspect.a012971  0.52
2012 Kazak L, Reyes A, Holt IJ. Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nature Reviews. Molecular Cell Biology. 13: 659-71. PMID 22992591 DOI: 10.1038/nrm3439  0.52
2012 Reijns MA, Rabe B, Rigby RE, Mill P, Astell KR, Lettice LA, Boyle S, Leitch A, Keighren M, Kilanowski F, Devenney PS, Sexton D, Grimes G, Holt IJ, Hill RE, et al. Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell. 149: 1008-22. PMID 22579044 DOI: 10.1016/j.cell.2012.04.011  0.52
2012 He J, Cooper HM, Reyes A, Di Re M, Sembongi H, Litwin TR, Gao J, Neuman KC, Fearnley IM, Spinazzola A, Walker JE, Holt IJ. Mitochondrial nucleoid interacting proteins support mitochondrial protein synthesis. Nucleic Acids Research. 40: 6109-21. PMID 22453275 DOI: 10.1093/nar/gks266  0.52
2012 He J, Cooper HM, Reyes A, Di Re M, Kazak L, Wood SR, Mao CC, Fearnley IM, Walker JE, Holt IJ. Human C4orf14 interacts with the mitochondrial nucleoid and is involved in the biogenesis of the small mitochondrial ribosomal subunit. Nucleic Acids Research. 40: 6097-108. PMID 22447445 DOI: 10.1093/nar/gks257  0.52
2012 Sewry CA, Quinlivan RC, Squier W, Morris GE, Holt I. A rapid immunohistochemical test to distinguish congenital myotonic dystrophy from X-linked myotubular myopathy. Neuromuscular Disorders : Nmd. 22: 225-30. PMID 22113158 DOI: 10.1016/j.nmd.2011.10.002  0.52
2012 Sharma NK, Reyes A, Green P, Caron MJ, Bonini MG, Gordon DM, Holt IJ, Santos JH. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Research. 40: 712-25. PMID 21937513 DOI: 10.1093/nar/gkr758  0.52
2011 Paul S, Dansithong W, Jog SP, Holt I, Mittal S, Brook JD, Morris GE, Comai L, Reddy S. Expanded CUG repeats Dysregulate RNA splicing by altering the stoichiometry of the muscleblind 1 complex. The Journal of Biological Chemistry. 286: 38427-38. PMID 21900255 DOI: 10.1074/jbc.M111.255224  0.52
2011 Tran H, Gourrier N, Lemercier-Neuillet C, Dhaenens CM, Vautrin A, Fernandez-Gomez FJ, Arandel L, Carpentier C, Obriot H, Eddarkaoui S, Delattre L, Van Brussels E, Holt I, Morris GE, Sablonnière B, et al. Analysis of exonic regions involved in nuclear localization, splicing activity, and dimerization of Muscleblind-like-1 isoforms. The Journal of Biological Chemistry. 286: 16435-46. PMID 21454535 DOI: 10.1074/jbc.M110.194928  0.52
2011 Reyes A, He J, Mao CC, Bailey LJ, Di Re M, Sembongi H, Kazak L, Dzionek K, Holmes JB, Cluett TJ, Harbour ME, Fearnley IM, Crouch RJ, Conti MA, Adelstein RS, ... ... Holt IJ, et al. Actin and myosin contribute to mammalian mitochondrial DNA maintenance. Nucleic Acids Research. 39: 5098-108. PMID 21398640 DOI: 10.1093/nar/gkr052  0.52
2011 Holt I, Thanh Lam L, Tomé S, Wansink DG, Te Riele H, Gourdon G, Morris GE. The mouse mismatch repair protein, MSH3, is a nucleoplasmic protein that aggregates into denser nuclear bodies under conditions of stress. Journal of Cellular Biochemistry. 112: 1612-21. PMID 21344488 DOI: 10.1002/jcb.23075  0.52
2011 Wielders EA, Dekker RJ, Holt I, Morris GE, te Riele H. Characterization of MSH2 variants by endogenous gene modification in mouse embryonic stem cells. Human Mutation. 32: 389-96. PMID 21309037 DOI: 10.1002/humu.21448  0.52
2011 Minczuk M, He J, Duch AM, Ettema TJ, Chlebowski A, Dzionek K, Nijtmans LG, Huynen MA, Holt IJ. TEFM (c17orf42) is necessary for transcription of human mtDNA. Nucleic Acids Research. 39: 4284-99. PMID 21278163 DOI: 10.1093/nar/gkq1224  0.52
2011 Hyvärinen AK, Pohjoismäki JL, Holt IJ, Jacobs HT. Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication. Molecular Biology Reports. 38: 1321-8. PMID 20577816 DOI: 10.1007/s11033-010-0233-9  0.52
2011 Holt I, Pham YCN. Nucleic acid polymers and applications of recombinant DNA technology Rsc Polymer Chemistry Series. 399-429.  0.52
2010 Suzuki Y, Holmes JB, Cerritelli SM, Sakhuja K, Minczuk M, Holt IJ, Crouch RJ. An upstream open reading frame and the context of the two AUG codons affect the abundance of mitochondrial and nuclear RNase H1. Molecular and Cellular Biology. 30: 5123-34. PMID 20823270 DOI: 10.1128/MCB.00619-10  0.52
2010 Poulton J, Chiaratti MR, Meirelles FV, Kennedy S, Wells D, Holt IJ. Transmission of mitochondrial DNA diseases and ways to prevent them. Plos Genetics. 6. PMID 20711358 DOI: 10.1371/journal.pgen.1001066  0.52
2010 Pohjoismäki JL, Holmes JB, Wood SR, Yang MY, Yasukawa T, Reyes A, Bailey LJ, Cluett TJ, Goffart S, Willcox S, Rigby RE, Jackson AP, Spelbrink JN, Griffith JD, Crouch RJ, ... ... Holt IJ, et al. Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid. Journal of Molecular Biology. 397: 1144-55. PMID 20184890 DOI: 10.1016/j.jmb.2010.02.029  0.52
2010 Fusté JM, Wanrooij S, Jemt E, Granycome CE, Cluett TJ, Shi Y, Atanassova N, Holt IJ, Gustafsson CM, Falkenberg M. Mitochondrial RNA polymerase is needed for activation of the origin of light-strand DNA replication. Molecular Cell. 37: 67-78. PMID 20129056 DOI: 10.1016/j.molcel.2009.12.021  0.52
2010 Holt IJ. Zen and the art of mitochondrial DNA maintenance. Trends in Genetics : Tig. 26: 103-9. PMID 20117854 DOI: 10.1016/j.tig.2009.12.011  0.52
2010 Mladinov M, Mayer D, Brcic L, Wolstencroft E, Man NT, Holt I, Hof PR, Morris GE, Šimic G. Astrocyte expression of D2-like dopamine receptors in the prefrontal cortex Translational Neuroscience. 1: 238-243. DOI: 10.2478/v10134-010-0035-6  0.52
2010 Holt I, Quinlivan RCM, Couto JM, Monckton DG, Morris GE. The use of buccal cells for rapid diagnosis of myotonic dystrophy type 1 Translational Neuroscience. 1: 195-199. DOI: 10.2478/v10134-010-0029-4  0.52
2009 Mao CC, Holt IJ. Clinical and molecular aspects of diseases of mitochondrial DNA instability. Chang Gung Medical Journal. 32: 354-69. PMID 19664342  0.52
2009 Di Re M, Sembongi H, He J, Reyes A, Yasukawa T, Martinsson P, Bailey LJ, Goffart S, Boyd-kirkup JD, Wong TS, Fersht AR, Spelbrink JN, Holt IJ. The accessory subunit of mitochondrial DNA polymerase γ determines the DNA content of mitochondrial nucleoids in human cultured cells Nucleic Acids Research. 37: 5701-5713. PMID 19625489 DOI: 10.1093/nar/gkp614  0.52
2009 Malena A, Loro E, Di Re M, Holt IJ, Vergani L. Inhibition of mitochondrial fission favours mutant over wild-type mitochondrial DNA. Human Molecular Genetics. 18: 3407-16. PMID 19561330 DOI: 10.1093/hmg/ddp281  0.52
2009 Holt IJ. Mitochondrial DNA replication and repair: all a flap. Trends in Biochemical Sciences. 34: 358-65. PMID 19559620 DOI: 10.1016/j.tibs.2009.03.007  0.52
2009 Pohjoismäki JL, Goffart S, Tyynismaa H, Willcox S, Ide T, Kang D, Suomalainen A, Karhunen PJ, Griffith JD, Holt IJ, Jacobs HT. Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks. The Journal of Biological Chemistry. 284: 21446-57. PMID 19525233 DOI: 10.1074/jbc.M109.016600  0.52
2009 Reyes A, Yasukawa T, Cluett TJ, Holt IJ. Analysis of mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 554: 15-35. PMID 19513665 DOI: 10.1007/978-1-59745-521-3_2  0.52
2009 Poulton J, Holt IJ. 163rd ENMC International Workshop: nucleoid and nucleotide biology in syndromes of mitochondrial DNA depletion myopathy 12-14 December 2008, Naarden, The Netherlands. Neuromuscular Disorders : Nmd. 19: 439-43. PMID 19464176 DOI: 10.1016/j.nmd.2009.04.009  0.52
2009 Tomé S, Holt I, Edelmann W, Morris GE, Munnich A, Pearson CE, Gourdon G. MSH2 ATPase domain mutation affects CTG*CAG repeat instability in transgenic mice. Plos Genetics. 5: e1000482. PMID 19436705 DOI: 10.1371/journal.pgen.1000482  0.52
2009 Bailey LJ, Cluett TJ, Reyes A, Prolla TA, Poulton J, Leeuwenburgh C, Holt IJ. Mice expressing an error-prone DNA polymerase in mitochondria display elevated replication pausing and chromosomal breakage at fragile sites of mitochondrial DNA. Nucleic Acids Research. 37: 2327-35. PMID 19244310 DOI: 10.1093/nar/gkp091  0.52
2009 Holt I, Jacquemin V, Fardaei M, Sewry CA, Butler-Browne GS, Furling D, Brook JD, Morris GE. Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle. The American Journal of Pathology. 174: 216-27. PMID 19095965 DOI: 10.2353/ajpath.2009.080520  0.52
2009 Iacovino M, Granycome C, Sembongi H, Bokori-Brown M, Butow RA, Holt IJ, Bateman JM. The conserved translocase Tim17 prevents mitochondrial DNA loss. Human Molecular Genetics. 18: 65-74. PMID 18826960 DOI: 10.1093/hmg/ddn313  0.52
2008 Dansithong W, Wolf CM, Sarkar P, Paul S, Chiang A, Holt I, Morris GE, Branco D, Sherwood MC, Comai L, Berul CI, Reddy S. Cytoplasmic CUG RNA foci are insufficient to elicit key DM1 features. Plos One. 3: e3968. PMID 19092997 DOI: 10.1371/journal.pone.0003968  0.52
2007 Reyes A, Yasukawa T, Holt IJ. Analysis of replicating mitochondrial DNA by two-dimensional agarose gel electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 372: 219-32. PMID 18314729 DOI: 10.1007/978-1-59745-365-3_16  0.52
2007 Hyvärinen AK, Pohjoismäki JL, Reyes A, Wanrooij S, Yasukawa T, Karhunen PJ, Spelbrink JN, Holt IJ, Jacobs HT. The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA. Nucleic Acids Research. 35: 6458-74. PMID 17884915 DOI: 10.1093/nar/gkm676  0.52
2007 Holt IJ, He J, Mao CC, Boyd-Kirkup JD, Martinsson P, Sembongi H, Reyes A, Spelbrink JN. Mammalian mitochondrial nucleoids: organizing an independently minded genome. Mitochondrion. 7: 311-21. PMID 17698423 DOI: 10.1016/j.mito.2007.06.004  0.52
2007 Vergani L, Malena A, Sabatelli P, Loro E, Cavallini L, Magalhaes P, Valente L, Bragantini F, Carrara F, Leger B, Poulton J, Russell AP, Holt IJ. Cultured muscle cells display defects of mitochondrial myopathy ameliorated by anti-oxidants. Brain : a Journal of Neurology. 130: 2715-24. PMID 17626036 DOI: 10.1093/brain/awm151  0.52
2007 He J, Mao CC, Reyes A, Sembongi H, Di Re M, Granycome C, Clippingdale AB, Fearnley IM, Harbour M, Robinson AJ, Reichelt S, Spelbrink JN, Walker JE, Holt IJ. The AAA+ protein ATAD3 has displacement loop binding properties and is involved in mitochondrial nucleoid organization. The Journal of Cell Biology. 176: 141-6. PMID 17210950 DOI: 10.1083/jcb.200609158  0.52
2006 Yasukawa T, Reyes A, Cluett TJ, Yang MY, Bowmaker M, Jacobs HT, Holt IJ. Replication of vertebrate mitochondrial DNA entails transient ribonucleotide incorporation throughout the lagging strand. The Embo Journal. 25: 5358-71. PMID 17066082 DOI: 10.1038/sj.emboj.7601392  0.52
2006 Kirino Y, Yasukawa T, Marjavaara SK, Jacobs HT, Holt IJ, Watanabe K, Suzuki T. Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Human Molecular Genetics. 15: 897-904. PMID 16446307 DOI: 10.1093/hmg/ddl007  0.52
2005 Yasukawa T, Kirino Y, Ishii N, Holt IJ, Jacobs HT, Makifuchi T, Fukuhara N, Ohta S, Suzuki T, Watanabe K. Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. Febs Letters. 579: 2948-52. PMID 15893315 DOI: 10.1016/j.febslet.2005.04.038  0.52
2005 Reyes A, Yang MY, Bowmaker M, Holt IJ. Bidirectional replication initiates at sites throughout the mitochondrial genome of birds. The Journal of Biological Chemistry. 280: 3242-50. PMID 15557283 DOI: 10.1074/jbc.M411916200  0.52
2003 Bowmaker M, Yang MY, Yasukawa T, Reyes A, Jacobs HT, Huberman JA, Holt IJ. Mammalian mitochondrial DNA replicates bidirectionally from an initiation zone. The Journal of Biological Chemistry. 278: 50961-9. PMID 14506235 DOI: 10.1074/jbc.M308028200  0.52
2003 Holt I, Ostlund C, Stewart CL, Man Nt, Worman HJ, Morris GE. Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo. Journal of Cell Science. 116: 3027-35. PMID 12783988 DOI: 10.1242/jcs.00599  0.52
2002 Yang MY, Bowmaker M, Reyes A, Vergani L, Angeli P, Gringeri E, Jacobs HT, Holt IJ. Biased incorporation of ribonucleotides on the mitochondrial L-strand accounts for apparent strand-asymmetric DNA replication. Cell. 111: 495-505. PMID 12437923  0.52
1996 Dunbar DR, Moonie PA, Zeviani M, Holt IJ. Complex I deficiency is associated with 3243G:C mitochondrial DNA in osteosarcoma cell cybrids Human Molecular Genetics. 5: 123-129. PMID 8789449 DOI: 10.1093/hmg/5.1.123  0.52
1996 Marshall MJ, Holt I, Davie MW. Inhibition of prostaglandin synthesis leads to a change in adherence of mouse osteoclasts from bone to periosteum. Calcified Tissue International. 59: 207-13. PMID 8694899 DOI: 10.1007/s002239900110  0.52
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