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Gilles Thomas

Affiliations: 
Laboratoire des Tumeurs Institut Curie, Paris, France, Paris-5E-Arrondissement, Île-de-France, France 
Area:
Cancer genetics
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"Gilles Thomas"
Bio:

Gilles Thomas (1946-2014) graduated from the Ecole Polytechnique in 1970 and pursued a highly productive career in biology and medicine. After completing his PhD in biochemistry at University Paris VII, during which time he worked on the tertiary structure of E. Coli tRNAs in the laboratory of François Gros, he obtained a medical degree at the Pitie-Salpetriere University Hospital. Subsequently, he sought postdoctoral training in Norway and the USA. While a post-doctoral fellow, he published his first Nature paper on the structure of the amylase gene family in rat and was also awarded a laureate from the National Academy of Sciences and the National Academy of Medicine. By 1982, he established a vibrant research group at the Institut Curie, focused on the emerging field of cancer genetics. The main research focuses of his lab were on hereditary predisposition to cancer, particularly colon cancer, and on genetic abnormalities of human chromosome 22, projects he developed in strong interaction with Bernard Dutrillaux and Alain Aurias. In this environment, he trained a generation of French cancer geneticists in his laboratory, many of whom have become international leaders in the field, including Olivier Delattre, Pierre Laurent-Puig, Sylviane Olschwang, Annette Schmitz, Jessica Zucman and Anne Vincent-Salomon. He also developed a biology course at the Ecole Polytechnique.

[from http://symposium-gillesthomas.com/bio/]
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Publications

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Blein S, Barjhoux L, et al. (2015) Targeted Sequencing of the Mitochondrial Genome of Women at High Risk of Breast Cancer without Detectable Mutations in BRCA1/2. Plos One. 10: e0136192
Blein S, Bardel C, Danjean V, et al. (2015) An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers. Breast Cancer Research : Bcr. 17: 61
Stephens PJ, Tarpey PS, Davies H, et al. (2012) The landscape of cancer genes and mutational processes in breast cancer. Nature. 486: 400-4
Nik-Zainal S, Van Loo P, Wedge DC, et al. (2012) The life history of 21 breast cancers. Cell. 149: 994-1007
Jacobs KB, Yeager M, Zhou W, et al. (2012) Detectable clonal mosaicism and its relationship to aging and cancer. Nature Genetics. 44: 651-8
Postel-Vinay S, Véron AS, Tirode F, et al. (2012) Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. Nature Genetics. 44: 323-7
Lee P, Fu YP, Figueroa JD, et al. (2012) Fine mapping of 14q24.1 breast cancer susceptibility locus. Human Genetics. 131: 479-90
Ciampa J, Yeager M, Jacobs K, et al. (2011) Application of a novel score test for genetic association incorporating gene-gene interaction suggests functionality for prostate cancer susceptibility regions. Human Heredity. 72: 182-93
Rodríguez-Santiago B, Malats N, Rothman N, et al. (2010) Mosaic uniparental disomies and aneuploidies as large structural variants of the human genome. American Journal of Human Genetics. 87: 129-38
Rajaraman P, Brenner AV, Neta G, et al. (2010) Risk of meningioma and common variation in genes related to innate immunity. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 19: 1356-61
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