Paul Mischel, M.D.

Affiliations: 
Pathology University of California, San Diego, La Jolla, CA 
Area:
EGFR/PI3K/Akt/mTOR signaling network
Website:
http://www.ludwigcancerresearch.org/location/san-diego-branch/paul-s-mischel-lab
Google:
"Paul Mischel"
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Publications

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Dehkordi SR, Wong IT, Ni J, et al. (2023) Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change. Biorxiv : the Preprint Server For Biology
Masui K, Mischel PS. (2023) Metabolic and epigenetic reprogramming in the pathogenesis of glioblastoma: Toward the establishment of "metabolism-based pathology". Pathology International. 73: 533-541
Raviram R, Raman A, Preissl S, et al. (2023) Integrated analysis of single-cell chromatin state and transcriptome identified common vulnerability despite glioblastoma heterogeneity. Proceedings of the National Academy of Sciences of the United States of America. 120: e2210991120
West TJ, Bi J, Martínez-Peña F, et al. (2023) A Cell Type Selective YM155 Prodrug Targets Receptor-Interacting Protein Kinase 2 to Induce Brain Cancer Cell Death. Journal of the American Chemical Society
Pecorino LT, Verhaak RGW, Henssen A, et al. (2022) Extrachromosomal DNA (ecDNA): an origin of tumor heterogeneity, genomic remodeling, and drug resistance. Biochemical Society Transactions
Chen PB, Fiaux PC, Zhang K, et al. (2022) Systematic discovery and functional dissection of enhancers needed for cancer cell fitness and proliferation. Cell Reports. 41: 111630
Noorani I, Mischel PS, Swanton C. (2022) Leveraging extrachromosomal DNA to fine-tune trials of targeted therapy for glioblastoma: opportunities and challenges. Nature Reviews. Clinical Oncology
Lange JT, Rose JC, Chen CY, et al. (2022) The evolutionary dynamics of extrachromosomal DNA in human cancers. Nature Genetics
Masui K, Cavenee WK, Mischel PS, et al. (2022) The metabolomic landscape plays a critical role in glioma oncogenesis. Cancer Science
Bi J, Khan A, Tang J, et al. (2021) Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug. Cell Reports. 37: 109957
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