| Year |
Citation |
Score |
| 2023 |
Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, ... ... Karin M, et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. PMID 37100955 DOI: 10.1038/s41418-023-01153-w |
0.457 |
|
| 2020 |
Kudo Y, Sugimoto M, Arias E, Kasashima H, Cordes T, Linares JF, Duran A, Nakanishi Y, Nakanishi N, L'Hermitte A, Campos A, Senni N, Rooslid T, Roberts LR, Cuervo AM, ... ... Karin M, et al. PKCλ/ι Loss Induces Autophagy, Oxidative Phosphorylation, and NRF2 to Promote Liver Cancer Progression. Cancer Cell. PMID 32589943 DOI: 10.1016/J.Ccell.2020.05.018 |
0.352 |
|
| 2020 |
He F, Antonucci L, Karin M. NRF2 as a regulator of cell metabolism and inflammation in cancer. Carcinogenesis. PMID 32347301 DOI: 10.1093/carcin/bgaa039 |
0.364 |
|
| 2020 |
Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, ... ... Karin M, et al. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. Journal For Immunotherapy of Cancer. 8. PMID 32209603 DOI: 10.1136/Jitc-2019-000337 |
0.301 |
|
| 2020 |
Shalapour S, Karin M. Cruel to Be Kind: Epithelial, Microbial, and Immune Cell Interactions in Gastrointestinal Cancers. Annual Review of Immunology. PMID 32040356 DOI: 10.1146/annurev-immunol-082019-081656 |
0.329 |
|
| 2020 |
Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis. Science (New York, N.Y.). 367: 652-660. PMID 32029622 DOI: 10.1126/Science.Aay0542 |
0.355 |
|
| 2020 |
Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ, Karin M. NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. Cell Death and Differentiation. PMID 31992855 DOI: 10.1038/s41418-020-0496-1 |
0.408 |
|
| 2020 |
Namineni S, O'Connor T, Faure-Dupuy S, Johansen P, Riedl T, Liu K, Xu H, Singh I, Shinde P, Li F, Pandyra A, Sharma P, Ringelhan M, Muschaweckh A, Borst K, ... ... Karin M, et al. A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control. Journal of Hepatology. PMID 31954207 DOI: 10.1016/J.Jhep.2019.12.019 |
0.313 |
|
| 2019 |
Imamura T, Xue J, Poulsen O, Zhou D, Karin M, Haddad GG. Intermittent Hypoxia and Hypercapnia Induces Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta-dependent Atherosclerosis in Pulmonary Arteries. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 31618063 DOI: 10.1152/ajpregu.00056.2019 |
0.348 |
|
| 2019 |
Wong J, Garcia-Carbonell R, Zelic M, Ho SB, Boland BS, Yao SJ, Desai SA, Das S, Planell N, Harris PA, Font-Burgada J, Taniguchi K, Bertin J, Salas A, Pasparakis M, ... ... Karin M, et al. RIPK1 mediates TNF-induced intestinal crypt apoptosis during chronic NF-κB activation. Cellular and Molecular Gastroenterology and Hepatology. PMID 31606566 DOI: 10.1016/j.jcmgh.2019.10.002 |
0.369 |
|
| 2019 |
Todoric J, Karin M. The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer. Cancer Cell. 35: 714-720. PMID 31085174 DOI: 10.1016/j.ccell.2019.04.001 |
0.35 |
|
| 2019 |
Sanchez-Lopez E, Zhong Z, Stubelius A, Sweeney SR, Booshehri LM, Antonucci L, Liu-Bryan R, Lodi A, Terkeltaub R, Lacal JC, Murphy AN, Hoffman HM, Tiziani S, Guma M, Karin M. Choline Uptake and Metabolism Modulate Macrophage IL-1β and IL-18 Production. Cell Metabolism. PMID 30982734 DOI: 10.1016/J.Cmet.2019.03.011 |
0.328 |
|
| 2019 |
Gukovskaya AS, Gorelick FS, Groblewski GE, Mareninova OA, Lugea A, Antonucci L, Waldron RT, Habtezion A, Karin M, Pandol SJ, Gukovsky I. Recent Insights Into the Pathogenic Mechanism of Pancreatitis: Role of Acinar Cell Organelle Disorders. Pancreas. 48: 459-470. PMID 30973461 DOI: 10.1097/Mpa.0000000000001298 |
0.332 |
|
| 2019 |
Bastian IN, Li W, Phung Q, Fisch K, Lill J, Karin M, Shalapour S. Abstract 2247: Platinoid-induced MHCI antigen presentation enables checkpoint inhibitor responsiveness Cancer Research. 79: 2247-2247. DOI: 10.1158/1538-7445.Am2019-2247 |
0.37 |
|
| 2018 |
Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, ... ... Karin M, et al. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. PMID 30445007 DOI: 10.1053/J.Gastro.2018.11.019 |
0.306 |
|
| 2018 |
Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. PMID 30220454 DOI: 10.1016/J.Cell.2018.08.020 |
0.33 |
|
| 2018 |
Garcia-Carbonell R, Wong J, Kim JY, Close LA, Boland BS, Wong TL, Harris PA, Ho SB, Das S, Ernst PB, Sasik R, Sandborn WJ, Bertin J, Gough PJ, Chang JT, ... ... Karin M, et al. Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proceedings of the National Academy of Sciences of the United States of America. PMID 30209212 DOI: 10.1073/pnas.1810584115 |
0.313 |
|
| 2018 |
Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. PMID 30046112 DOI: 10.1038/S41586-018-0372-Z |
0.32 |
|
| 2018 |
Dhar D, Antonucci L, Nakagawa H, Kim JY, Glitzner E, Caruso S, Shalapour S, Yang L, Valasek MA, Lee S, Minnich K, Seki E, Tuckermann J, Sibilia M, Zucman-Rossi J, ... Karin M, et al. Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 33: 1061-1077.e6. PMID 29894692 DOI: 10.1016/J.Ccell.2018.05.003 |
0.359 |
|
| 2018 |
Liu JJ, Li Y, Chen WS, Liang Y, Wang G, Zong M, Kaneko K, Xu R, Karin M, Feng GS. Shp2 Deletion in Hepatocytes Suppresses Hepatocarcinogenesis Driven by Oncogenic β-Catenin, PIK3CA and MET. Journal of Hepatology. PMID 29505847 DOI: 10.1016/J.Jhep.2018.02.014 |
0.319 |
|
| 2018 |
Taniguchi K, Karin M. NF-κB, inflammation, immunity and cancer: coming of age. Nature Reviews. Immunology. PMID 29379212 DOI: 10.1038/nri.2017.142 |
0.317 |
|
| 2018 |
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, ... ... Karin M, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. PMID 29362479 DOI: 10.1038/S41418-017-0012-4 |
0.489 |
|
| 2018 |
Song NY, Zhu F, Wang Z, Willette-Brown J, Xi S, Sun Z, Su L, Wu X, Ma B, Nussinov R, Xia X, Schrump DS, Johnson PF, Karin M, Hu Y. IKKα inactivation promotes Kras-initiated lung adenocarcinoma development through disrupting major redox regulatory pathways. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311298 DOI: 10.1073/Pnas.1717520115 |
0.305 |
|
| 2018 |
Sanchez-Lopez E, Ghia EM, Antonucci L, Rassenti LZ, Chen Y, Kipps TJ, Karin M. Activation of NF-Kappa B-p62-NRF2 Signaling Supports the Survival of CLL Cells That Express High Levels of ROR1 Blood. 132: 3122-3122. DOI: 10.1182/Blood-2018-99-115564 |
0.347 |
|
| 2017 |
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, ... ... Karin M, et al. Erratum: Inflammation-induced IgA(+) cells dismantle anti-liver cancer immunity. Nature. PMID 29168501 DOI: 10.1038/Nature25028 |
0.316 |
|
| 2017 |
Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle NK, Dhar D, Banerjee S, Fagman JB, Browne CD, Umemura A, Valasek MA, Kessler H, Tarin D, Goggins M, ... ... Karin M, et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. PMID 29153842 DOI: 10.1016/J.Ccell.2017.10.011 |
0.352 |
|
| 2017 |
Shalapour S, Lin XJ, Bastian IN, Brain J, Burt AD, Aksenov AA, Vrbanac AF, Li W, Perkins A, Matsutani T, Zhong Z, Dhar D, Navas-Molina JA, Xu J, Loomba R, ... ... Karin M, et al. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature. 551: 340-345. PMID 29144460 DOI: 10.1038/Nature24302 |
0.344 |
|
| 2017 |
Matsushita N, Hassanein MT, Martinez-Clemente M, Lazaro R, French SW, Xie W, Lai K, Karin M, Tsukamoto H. Gender difference in NASH susceptibility: Roles of hepatocyte Ikkβ and Sult1e1. Plos One. 12: e0181052. PMID 28797077 DOI: 10.1371/Journal.Pone.0181052 |
0.302 |
|
| 2017 |
Ivovic A, Oprescu AI, Koulajian K, Mori Y, Eversley JA, Zhang L, Nino-Fong R, Lewis GF, Donath MY, Karin M, Wheeler MB, Ehses J, Volchuk A, Chan CB, Giacca A. IKKβ inhibition prevents fat-induced beta cell dysfunction in vitro and in vivo in rodents. Diabetologia. PMID 28725915 DOI: 10.1007/S00125-017-4345-9 |
0.349 |
|
| 2017 |
Afonina IS, Zhong Z, Karin M, Beyaert R. Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome. Nature Immunology. 18: 861-869. PMID 28722711 DOI: 10.1038/Ni.3772 |
0.341 |
|
| 2017 |
Xing W, Xiao Y, Lu X, Zhu H, He X, Huang W, Lopez ES, Wong J, Ju H, Tian L, Zhang F, Xu H, Wang SD, Li X, Karin M, et al. GFI1 downregulation promotes inflammation-linked metastasis of colorectal cancer. Cell Death and Differentiation. PMID 28387757 DOI: 10.1038/cdd.2017.50 |
0.332 |
|
| 2017 |
Chen S, Lu W, Yueh MF, Rettenmeier E, Liu M, Auwerx J, Yu RT, Evans RM, Wang K, Karin M, Tukey RH. Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia. Proceedings of the National Academy of Sciences of the United States of America. PMID 28167773 DOI: 10.1073/Pnas.1700232114 |
0.305 |
|
| 2017 |
Taniguchi K, Moroishi T, de Jong PR, Krawczyk M, Grebbin BM, Luo H, Xu RH, Golob-Schwarzl N, Schweiger C, Wang K, Di Caro G, Feng Y, Fearon ER, Raz E, Kenner L, ... ... Karin M, et al. YAP-IL-6ST autoregulatory loop activated on APC loss controls colonic tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28130546 DOI: 10.1073/Pnas.1620290114 |
0.379 |
|
| 2017 |
Lanna A, Gomes DC, Muller-Durovic B, McDonnell T, Escors D, Gilroy DW, Lee JH, Karin M, Akbar AN. A sestrin-dependent Erk-Jnk-p38 MAPK activation complex inhibits immunity during aging. Nature Immunology. PMID 28114291 DOI: 10.1038/ni.3665 |
0.38 |
|
| 2017 |
Karin M. Abstract SY19-01: Tumor-elicited inflammation in colorectal cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Sy19-01 |
0.349 |
|
| 2016 |
Todoric J, Antonucci L, Karin M. Targeting Inflammation in Cancer Prevention and Therapy. Cancer Prevention Research (Philadelphia, Pa.). 9: 895-905. PMID 27913448 DOI: 10.1158/1940-6207.CAPR-16-0209 |
0.306 |
|
| 2016 |
Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction. Cell. 167: 1052-1066.e18. PMID 27814504 DOI: 10.1016/j.cell.2016.10.015 |
0.36 |
|
| 2016 |
Moscat J, Karin M, Diaz-Meco MT. p62 in Cancer: Signaling Adaptor Beyond Autophagy. Cell. 167: 606-609. PMID 27768885 DOI: 10.1016/j.cell.2016.09.030 |
0.323 |
|
| 2016 |
Duran A, Hernandez ED, Reina-Campos M, Castilla EA, Subramaniam S, Raghunandan S, Roberts LR, Kisseleva T, Karin M, Diaz-Meco MT, Moscat J. p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer. Cancer Cell. 30: 595-609. PMID 27728806 DOI: 10.1016/J.Ccell.2016.09.004 |
0.329 |
|
| 2016 |
Kaneda MM, Messer KS, Ralainirina N, Li H, Leem C, Gorjestani S, Woo G, Nguyen AV, Figueiredo CC, Foubert P, Schmid MC, Pink M, Winkler DG, Rausch M, Palombella VJ, ... ... Karin M, et al. PI3Kγ is a molecular switch that controls immune suppression. Nature. PMID 27642729 DOI: 10.1038/Nature19834 |
0.411 |
|
| 2016 |
Zhong Z, Sanchez-Lopez E, Karin M. Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment. Cell. 166: 288-98. PMID 27419869 DOI: 10.1016/J.Cell.2016.05.051 |
0.32 |
|
| 2016 |
Taniguchi K, Yamachika S, He F, Karin M. p62/SQSTM1- Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer. Febs Letters. PMID 27404485 DOI: 10.1002/1873-3468.12301 |
0.356 |
|
| 2016 |
Koppe C, Verheugd P, Gautheron J, Reisinger F, Kreggenwinkel K, Roderburg C, Quagliata L, Terracciano L, Gassler N, Tolba RH, Boege Y, Weber A, Karin M, Luedde M, Neumann UP, et al. IKKα/β control biliary homeostasis and hepatocarcinogenesis in mice by phosphorylating the cell-death mediator RIPK1. Hepatology (Baltimore, Md.). PMID 27396433 DOI: 10.1002/hep.28723 |
0.439 |
|
| 2016 |
McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS. Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer. Cell Reports. PMID 27320908 DOI: 10.1016/J.Celrep.2016.05.085 |
0.316 |
|
| 2016 |
Lee JH, Cho US, Karin M. Sestrin regulation of TORC1: Is Sestrin a leucine sensor? Science Signaling. 9: re5. PMID 27273098 DOI: 10.1126/scisignal.aaf2885 |
0.379 |
|
| 2016 |
Umemura A, He F, Taniguchi K, Nakagawa H, Yamachika S, Font-Burgada J, Zhong Z, Subramaniam S, Raghunandan S, Duran A, Linares JF, Reina-Campos M, Umemura S, Valasek MA, Seki E, ... ... Karin M, et al. p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells. Cancer Cell. PMID 27211490 DOI: 10.1016/J.Ccell.2016.04.006 |
0.304 |
|
| 2016 |
de Jong PR, Taniguchi K, Harris AR, Bertin S, Takahashi N, Duong J, Campos AD, Powis G, Corr M, Karin M, Raz E. ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation. Nature Communications. 7: 11551. PMID 27187615 DOI: 10.1038/ncomms11551 |
0.363 |
|
| 2016 |
Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, ... ... Karin M, et al. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 164: 896-910. PMID 26919428 DOI: 10.1016/J.Cell.2015.12.057 |
0.386 |
|
| 2016 |
Caballero-Franco C, Guma M, Choo MK, Sano Y, Enzler T, Karin M, Mizoguchi A, Park JM. Epithelial Control of Gut-Associated Lymphoid Tissue Formation through p38α-Dependent Restraint of NF-κB Signaling. Journal of Immunology (Baltimore, Md. : 1950). PMID 26792803 DOI: 10.4049/jimmunol.1501724 |
0.391 |
|
| 2016 |
Shalapour S, Karin M. Abstract B045: Immunosuppressive plasmocytes impede T-cell-dependent immunogenic chemotherapy Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-B045 |
0.35 |
|
| 2016 |
Zhong Z, Umemura A, Liang S, Karin M. Abstract A138: Identification of key immune regulators that control obesity-induced liver inflammation and diseases Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A138 |
0.343 |
|
| 2016 |
Shalapour S, Karin M. Abstract A095: Immunosuppressive plasmocytes regulate the development of NASH-induced HCC Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A095 |
0.318 |
|
| 2016 |
Zhong Z, Karin M. Abstract A066: NF-kB restricts inflammasome activation via elimination of damaged mitochondria Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-A066 |
0.388 |
|
| 2016 |
Karin M. Abstract IA08: p62/SQSTM1 accumulation links chronic tissue damage to malignant progression in liver and pancreas Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-Ia08 |
0.335 |
|
| 2015 |
Rosati A, Basile A, D'Auria R, d'Avenia M, De Marco M, Falco A, Festa M, Guerriero L, Iorio V, Parente R, Pascale M, Marzullo L, Franco R, Arra C, Barbieri A, ... ... Karin M, et al. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nature Communications. 6: 8695. PMID 26522614 DOI: 10.1038/Ncomms9695 |
0.367 |
|
| 2015 |
Antonucci L, Fagman JB, Kim JY, Todoric J, Gukovsky I, Mackey M, Ellisman MH, Karin M. Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress. Proceedings of the National Academy of Sciences of the United States of America. PMID 26512112 DOI: 10.1073/pnas.1519384112 |
0.326 |
|
| 2015 |
Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, ... ... Karin M, et al. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nature Immunology. PMID 26502405 DOI: 10.1038/Ni.3290 |
0.343 |
|
| 2015 |
Vallabhapurapu SD, Noothi SK, Pullum DA, Lawrie CH, Pallapati R, Potluri V, Kuntzen C, Khan S, Plas DR, Orlowski RZ, Chesi M, Kuehl WM, Bergsagel PL, Karin M, Vallabhapurapu S. Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth. Nature Communications. 6: 8428. PMID 26455434 DOI: 10.1038/ncomms9428 |
0.377 |
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| 2015 |
Sig Kim J, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Hee Lee J. Corrigendum: Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Scientific Reports. 5: 14029. PMID 26390293 DOI: 10.1038/Srep14029 |
0.378 |
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| 2015 |
Sanchez-Lopez E, Flashner-Abramson E, Shalapour S, Zhong Z, Taniguchi K, Levitzki A, Karin M. Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling. Oncogene. PMID 26364612 DOI: 10.1038/Onc.2015.326 |
0.39 |
|
| 2015 |
Shalapour S, Karin M. Immunity, inflammation, and cancer: an eternal fight between good and evil. The Journal of Clinical Investigation. 125: 3347-55. PMID 26325032 DOI: 10.1172/JCI80007 |
0.327 |
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| 2015 |
Wang K, Karin M. Tumor-Elicited Inflammation and Colorectal Cancer. Advances in Cancer Research. 128: 173-96. PMID 26216633 DOI: 10.1016/Bs.Acr.2015.04.014 |
0.313 |
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| 2015 |
Vlahopoulos SA, Cen O, Hengen N, Agan J, Moschovi M, Critselis E, Adamaki M, Bacopoulou F, Copland JA, Boldogh I, Karin M, Chrousos GP. Dynamic aberrant NF-κB spurs tumorigenesis: a new model encompassing the microenvironment. Cytokine & Growth Factor Reviews. 26: 389-403. PMID 26119834 DOI: 10.1016/j.cytogfr.2015.06.001 |
0.39 |
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| 2015 |
Moroishi T, Park HW, Qin B, Chen Q, Meng Z, Plouffe SW, Taniguchi K, Yu FX, Karin M, Pan D, Guan KL. A YAP/TAZ-induced feedback mechanism regulates Hippo pathway homeostasis. Genes & Development. 29: 1271-84. PMID 26109050 DOI: 10.1101/gad.262816.115 |
0.436 |
|
| 2015 |
Wu X, Karin M. Emerging roles of Lys63-linked polyubiquitylation in immune responses. Immunological Reviews. 266: 161-74. PMID 26085214 DOI: 10.1111/imr.12310 |
0.322 |
|
| 2015 |
Shalapour S, Font-Burgada J, Di Caro G, Zhong Z, Sanchez-Lopez E, Dhar D, Willimsky G, Ammirante M, Strasner A, Hansel DE, Jamieson C, Kane CJ, Klatte T, Birner P, Kenner L, ... Karin M, et al. Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy. Nature. 521: 94-8. PMID 25924065 DOI: 10.1038/Nature14395 |
0.373 |
|
| 2015 |
Wree A, Johnson CD, Font-Burgada J, Eguchi A, Povero D, Karin M, Feldstein AE. Hepatocyte-specific Bid depletion reduces tumor development by suppressing inflammation-related compensatory proliferation. Cell Death and Differentiation. PMID 25909884 DOI: 10.1038/cdd.2015.46 |
0.332 |
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| 2015 |
Kim JS, Ro SH, Kim M, Park HW, Semple IA, Park H, Cho US, Wang W, Guan KL, Karin M, Lee JH. Sestrin2 inhibits mTORC1 through modulation of GATOR complexes. Scientific Reports. 5: 9502. PMID 25819761 DOI: 10.1038/Srep09502 |
0.378 |
|
| 2015 |
Shaked H, Guma M, Karin M. Analysis of NF-κB activation in mouse intestinal epithelial cells. Methods in Molecular Biology (Clifton, N.J.). 1280: 593-606. PMID 25736774 DOI: 10.1007/978-1-4939-2422-6_35 |
0.393 |
|
| 2015 |
Taniguchi K, Wu LW, Grivennikov SI, de Jong PR, Lian I, Yu FX, Wang K, Ho SB, Boland BS, Chang JT, Sandborn WJ, Hardiman G, Raz E, Maehara Y, Yoshimura A, ... ... Karin M, et al. A gp130-Src-YAP module links inflammation to epithelial regeneration. Nature. 519: 57-62. PMID 25731159 DOI: 10.1038/Nature14228 |
0.386 |
|
| 2015 |
Kobayashi K, Toguchida J, Karin M, Kato T. IKKβ in postnatal perichondrium remotely controls endochondral ossification of the growth plate through downregulation of MCP-5. Cell Death and Differentiation. 22: 852-61. PMID 25526093 DOI: 10.1038/cdd.2014.192 |
0.327 |
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| 2015 |
Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, Budanov A, Lee JH, Karin M, Li J. Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 408-17. PMID 25366347 DOI: 10.1096/fj.14-258814 |
0.301 |
|
| 2015 |
Karin M. Abstract IA02: The intersection of inflammation, immunity, and cancer: From basic biology to translational research Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-Ia02 |
0.354 |
|
| 2015 |
Karin M. Abstract PL03-03: ER stress and TNF signaling control the progression from simple steatosis to non-alcoholic steatohepatitis (NASH) Cancer Prevention Research. 8. DOI: 10.1158/1940-6215.Prev-14-Pl03-03 |
0.334 |
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| 2015 |
Rosati A, Basile A, D'Auria R, d'Avenia M, Marco MD, Falco A, Festa M, Guerriero L, Iorio V, Pascale M, Franco R, Arra C, Barbieri A, Rea D, Menichini G, ... ... Karin M, et al. Abstract 2393: PDAC cells release BAG3 that activates a paracrine loop with stromal macrophages Cancer Research. 75: 2393-2393. DOI: 10.1158/1538-7445.Am2015-2393 |
0.382 |
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| 2014 |
Parmigiani A, Nourbakhsh A, Ding B, Wang W, Kim YC, Akopiants K, Guan KL, Karin M, Budanov AV. Sestrins inhibit mTORC1 kinase activation through the GATOR complex. Cell Reports. 9: 1281-91. PMID 25457612 DOI: 10.1016/J.Celrep.2014.10.019 |
0.379 |
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| 2014 |
Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, Karin M, Tukey RH. The commonly used antimicrobial additive triclosan is a liver tumor promoter. Proceedings of the National Academy of Sciences of the United States of America. 111: 17200-5. PMID 25404284 DOI: 10.1073/Pnas.1419119111 |
0.324 |
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| 2014 |
Yang J, Hawkins OE, Barham W, Gilchuk P, Boothby M, Ayers GD, Joyce S, Karin M, Yull FE, Richmond A. Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response. Cancer Research. 74: 7274-84. PMID 25336190 DOI: 10.1158/0008-5472.Can-14-1091 |
0.363 |
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| 2014 |
Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, ... ... Karin M, et al. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell. 26: 549-64. PMID 25314080 DOI: 10.1016/J.Ccell.2014.09.003 |
0.323 |
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| 2014 |
Karin M. Whipping NF-κB to Submission via GADD45 and MKK7. Cancer Cell. 26: 447-9. PMID 25314072 DOI: 10.1016/j.ccell.2014.09.012 |
0.347 |
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| 2014 |
Ammirante M, Shalapour S, Kang Y, Jamieson CA, Karin M. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 111: 14776-81. PMID 25267627 DOI: 10.1073/pnas.1416498111 |
0.347 |
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| 2014 |
Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, ... Karin M, et al. IKKα negatively regulates ASC-dependent inflammasome activation. Nature Communications. 5: 4977. PMID 25266676 DOI: 10.1038/Ncomms5977 |
0.406 |
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| 2014 |
Charlaftis N, Suddason T, Wu X, Anwar S, Karin M, Gallagher E. The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines. The Embo Journal. 33: 2581-96. PMID 25260751 DOI: 10.15252/embj.201488351 |
0.398 |
|
| 2014 |
Wu X, Zhang W, Font-Burgada J, Palmer T, Hamil AS, Biswas SK, Poidinger M, Borcherding N, Xie Q, Ellies LG, Lytle NK, Wu LW, Fox RG, Yang J, Dowdy SF, ... ... Karin M, et al. Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade. Proceedings of the National Academy of Sciences of the United States of America. 111: 13870-5. PMID 25189770 DOI: 10.1073/Pnas.1414358111 |
0.373 |
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| 2014 |
Fang DF, He K, Wang N, Sang ZH, Qiu X, Xu G, Jian Z, Liang B, Li T, Li HY, Li AL, Zhou T, Gong WL, Yang B, Karin M, et al. NEDD4 ubiquitinates TRAF3 to promote CD40-mediated AKT activation. Nature Communications. 5: 4513. PMID 25072696 DOI: 10.1038/ncomms5513 |
0.34 |
|
| 2014 |
Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, ... ... Karin M, et al. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. The Journal of Clinical Investigation. 124: 3566-78. PMID 24983318 DOI: 10.1172/Jci74068 |
0.42 |
|
| 2014 |
Umemura A, Park EJ, Taniguchi K, Lee JH, Shalapour S, Valasek MA, Aghajan M, Nakagawa H, Seki E, Hall MN, Karin M. Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition. Cell Metabolism. 20: 133-44. PMID 24910242 DOI: 10.1016/J.Cmet.2014.05.001 |
0.331 |
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| 2014 |
Kanarek N, Grivennikov SI, Leshets M, Lasry A, Alkalay I, Horwitz E, Shaul YD, Stachler M, Voronov E, Apte RN, Pagano M, Pikarsky E, Karin M, Ghosh S, Ben-Neriah Y. Critical role for IL-1β in DNA damage-induced mucositis. Proceedings of the National Academy of Sciences of the United States of America. 111: E702-11. PMID 24469832 DOI: 10.1073/Pnas.1322691111 |
0.317 |
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| 2014 |
Wilson CL, Mann J, Walsh M, Perrugoria MJ, Oakley F, Wright MC, Brignole C, Di Paolo D, Perri P, Ponzoni M, Karin M, Mann DA. Quiescent hepatic stellate cells functionally contribute to the hepatic innate immune response via TLR3. Plos One. 9: e83391. PMID 24416163 DOI: 10.1371/journal.pone.0083391 |
0.325 |
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| 2014 |
Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, ... ... Karin M, et al. Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis. Proceedings of the National Academy of Sciences of the United States of America. 111: 1090-5. PMID 24395807 DOI: 10.1073/Pnas.1322731111 |
0.306 |
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| 2014 |
Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, Mann J, Oakley F, Howarth R, Brain J, Masson S, Karin M, Seki E, Mann DA. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. Journal of Hepatology. 60: 782-91. PMID 24333183 DOI: 10.1016/J.Jhep.2013.12.005 |
0.319 |
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| 2014 |
Bonnegarde-Bernard A, Jee J, Fial MJ, Aeffner F, Cormet-Boyaka E, Davis IC, Lin M, Tomé D, Karin M, Sun Y, Boyaka PN. IKKβ in intestinal epithelial cells regulates allergen-specific IgA and allergic inflammation at distant mucosal sites. Mucosal Immunology. 7: 257-67. PMID 23839064 DOI: 10.1038/mi.2013.43 |
0.311 |
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| 2014 |
Karin M. Abstract SY40-01: Tumor elicited inflammation and malignant progression in colorectal cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy40-01 |
0.341 |
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| 2014 |
Suetsugu A, Ogata H, Hiroshima Y, Momiyama M, Osawa Y, Moriwaki H, Saji S, Karin M, Hoffman RM. Abstract 3: Imaging of stromal cells during hepatocellular metastasis formation in the RFP-MUP-uPA mouse Cancer Research. 74: 3-3. DOI: 10.1158/1538-7445.Am2014-3 |
0.316 |
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| 2013 |
Wang K, Karin M. Common flora and intestine: A carcinogenic marriage. Cellular Logistics. 3: e24975. PMID 24516778 DOI: 10.4161/Cl.24975 |
0.302 |
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| 2013 |
Chen S, Yueh MF, Bigo C, Barbier O, Wang K, Karin M, Nguyen N, Tukey RH. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proceedings of the National Academy of Sciences of the United States of America. 110: 19143-8. PMID 24191041 DOI: 10.1073/Pnas.1319123110 |
0.309 |
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| 2013 |
He G, Dhar D, Nakagawa H, Font-Burgada J, Ogata H, Jiang Y, Shalapour S, Seki E, Yost SE, Jepsen K, Frazer KA, Harismendy O, Hatziapostolou M, Iliopoulos D, Suetsugu A, ... ... Karin M, et al. Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell. 155: 384-96. PMID 24120137 DOI: 10.1016/J.Cell.2013.09.031 |
0.307 |
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| 2013 |
Ma J, Bang BR, Lu J, Eun SY, Otsuka M, Croft M, Tobias P, Han J, Takeuchi O, Akira S, Karin M, Yagita H, Kang YJ. The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Science Signaling. 6: ra87. PMID 24084649 DOI: 10.1126/scisignal.2004431 |
0.367 |
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| 2013 |
Lee JH, Budanov AV, Karin M. Sestrins orchestrate cellular metabolism to attenuate aging. Cell Metabolism. 18: 792-801. PMID 24055102 DOI: 10.1016/j.cmet.2013.08.018 |
0.316 |
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| 2013 |
Ammirante M, Kuraishy AI, Shalapour S, Strasner A, Ramirez-Sanchez C, Zhang W, Shabaik A, Karin M. An IKKα-E2F1-BMI1 cascade activated by infiltrating B cells controls prostate regeneration and tumor recurrence. Genes & Development. 27: 1435-40. PMID 23796898 DOI: 10.1101/Gad.220202.113 |
0.341 |
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| 2013 |
Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M. A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell. 23: 647-59. PMID 23602409 DOI: 10.1016/J.Ccr.2013.03.012 |
0.413 |
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| 2013 |
Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, ... ... Karin M, et al. Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice. The Journal of Clinical Investigation. 123: 2231-43. PMID 23563314 DOI: 10.1172/Jci64498 |
0.781 |
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| 2013 |
Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T. I kappa B kinase alpha (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection. The Embo Journal. 32: 816-28. PMID 23422957 DOI: 10.1038/emboj.2013.28 |
0.334 |
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| 2013 |
Du H, Sun X, Guma M, Luo J, Ouyang H, Zhang X, Zeng J, Quach J, Nguyen DH, Shaw PX, Karin M, Zhang K. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America. 110: 2377-82. PMID 23341606 DOI: 10.1073/pnas.1221729110 |
0.313 |
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| 2013 |
Sakurai T, Kudo M, Umemura A, He G, Elsharkawy AM, Seki E, Karin M. p38α inhibits liver fibrogenesis and consequent hepatocarcinogenesis by curtailing accumulation of reactive oxygen species. Cancer Research. 73: 215-24. PMID 23271722 DOI: 10.1158/0008-5472.CAN-12-1602 |
0.327 |
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| 2013 |
Wang K, Grivennikov SI, Karin M. Implications of anti-cytokine therapy in colorectal cancer and autoimmune diseases. Annals of the Rheumatic Diseases. 72: ii100-3. PMID 23253923 DOI: 10.1136/Annrheumdis-2012-202201 |
0.333 |
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| 2013 |
Mazor R, Alsaigh T, Shaked H, Altshuler AE, Pocock ES, Kistler EB, Karin M, Schmid-Schönbein GW. Matrix metalloproteinase-1-mediated up-regulation of vascular endothelial growth factor-2 in endothelial cells. The Journal of Biological Chemistry. 288: 598-607. PMID 23155052 DOI: 10.1074/Jbc.M112.417451 |
0.31 |
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| 2013 |
Ammirante M, Kang Y, Karin M. Abstract PR3: Myofibroblasts activated upon tissue injury and hypoxia promote development of castration-resistant prostate cancer. Cancer Research. 73. DOI: 10.1158/1538-7445.Tumimm2012-Pr3 |
0.32 |
|
| 2012 |
Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, ... ... Karin M, et al. Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature. 491: 254-8. PMID 23034650 DOI: 10.1038/Nature11465 |
0.33 |
|
| 2012 |
Lee JH, Budanov AV, Talukdar S, Park EJ, Park HL, Park HW, Bandyopadhyay G, Li N, Aghajan M, Jang I, Wolfe AM, Perkins GA, Ellisman MH, Bier E, Scadeng M, ... ... Karin M, et al. Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3. Cell Metabolism. 16: 311-21. PMID 22958918 DOI: 10.1016/J.Cmet.2012.08.004 |
0.33 |
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| 2012 |
Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M. Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation. Proceedings of the National Academy of Sciences of the United States of America. 109: 14007-12. PMID 22893683 DOI: 10.1073/Pnas.1211509109 |
0.343 |
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| 2012 |
Gaba A, Grivennikov SI, Do MV, Stumpo DJ, Blackshear PJ, Karin M. Cutting edge: IL-10-mediated tristetraprolin induction is part of a feedback loop that controls macrophage STAT3 activation and cytokine production. Journal of Immunology (Baltimore, Md. : 1950). 189: 2089-93. PMID 22865915 DOI: 10.4049/jimmunol.1201126 |
0.334 |
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| 2012 |
Bebien M, Hensler ME, Davanture S, Hsu LC, Karin M, Park JM, Alexopoulou L, Liu GY, Nizet V, Lawrence T. The pore-forming toxin β hemolysin/cytolysin triggers p38 MAPK-dependent IL-10 production in macrophages and inhibits innate immunity. Plos Pathogens. 8: e1002812. PMID 22829768 DOI: 10.1371/Journal.Ppat.1002812 |
0.333 |
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| 2012 |
Seki E, Brenner DA, Karin M. A liver full of JNK: signaling in regulation of cell function and disease pathogenesis, and clinical approaches. Gastroenterology. 143: 307-20. PMID 22705006 DOI: 10.1053/J.Gastro.2012.06.004 |
0.436 |
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| 2012 |
Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu Y. IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis. Blood. 119: 5467-77. PMID 22544702 DOI: 10.1182/blood-2012-01-401547 |
0.342 |
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| 2012 |
Guma M, Hammaker D, Topolewski K, Corr M, Boyle DL, Karin M, Firestein GS. Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis and Rheumatism. 64: 2887-95. PMID 22488549 DOI: 10.1002/art.34489 |
0.345 |
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| 2012 |
DiDonato JA, Mercurio F, Karin M. NF-κB and the link between inflammation and cancer. Immunological Reviews. 246: 379-400. PMID 22435567 DOI: 10.1111/j.1600-065X.2012.01099.x |
0.364 |
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| 2012 |
Lancaster GI, Skiba B, Yang C, Nicholls HT, Langley KG, Chan MH, Bruce CR, Rewcastle GW, Shepherd PR, Karin M, Febbraio MA. IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade. The Biochemical Journal. 442: 723-32. PMID 22364283 DOI: 10.1042/BJ4520171 |
0.329 |
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| 2012 |
Aghajan M, Li N, Karin M. Obesity, autophagy and the pathogenesis of liver and pancreatic cancers. Journal of Gastroenterology and Hepatology. 27: 10-4. PMID 22320909 DOI: 10.1111/j.1440-1746.2011.07008.x |
0.302 |
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| 2012 |
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proceedings of the National Academy of Sciences of the United States of America. 109: E177-86. PMID 22203995 DOI: 10.1073/pnas.1119296109 |
0.439 |
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| 2012 |
Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, ... ... Karin M, et al. IKKα activation of NOTCH links tumorigenesis via FOXA2 suppression. Molecular Cell. 45: 171-84. PMID 22196886 DOI: 10.1016/J.Molcel.2011.11.018 |
0.421 |
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| 2012 |
Fujiwara R, Chen S, Karin M, Tukey RH. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia. Gastroenterology. 142: 109-118.e2. PMID 21983082 DOI: 10.1053/J.Gastro.2011.09.045 |
0.32 |
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| 2012 |
Suetsugu A, Ogata H, Moriwaki H, Saji S, Karin M, Hoffman RM. Abstract 5533: Imaging stromal recruitment during liver metastasis formation in the GFP-MUP-uPA mouse Cancer Research. 72: 5533-5533. DOI: 10.1158/1538-7445.Am2012-5533 |
0.33 |
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| 2011 |
Enzler T, Sano Y, Choo MK, Cottam HB, Karin M, Tsao H, Park JM. Cell-selective inhibition of NF-κB signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discovery. 1: 496-507. PMID 22389871 DOI: 10.1158/2159-8290.CD-11-0143 |
0.384 |
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| 2011 |
Kuraishy A, Karin M, Grivennikov SI. Tumor promotion via injury- and death-induced inflammation. Immunity. 35: 467-77. PMID 22035839 DOI: 10.1016/j.immuni.2011.09.006 |
0.371 |
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| 2011 |
Holzer RG, Park EJ, Li N, Tran H, Chen M, Choi C, Solinas G, Karin M. Saturated fatty acids induce c-Src clustering within membrane subdomains, leading to JNK activation. Cell. 147: 173-84. PMID 21962514 DOI: 10.1016/J.Cell.2011.08.034 |
0.784 |
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| 2011 |
Taoufik E, Tseveleki V, Chu SY, Tselios T, Karin M, Lassmann H, Szymkowski DE, Probert L. Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. Brain : a Journal of Neurology. 134: 2722-35. PMID 21908876 DOI: 10.1093/brain/awr203 |
0.333 |
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| 2011 |
Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M. Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation. The Journal of Experimental Medicine. 208: 1889-900. PMID 21825016 DOI: 10.1084/Jem.20110242 |
0.425 |
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| 2011 |
Stebbins JL, De SK, Pavlickova P, Chen V, Machleidt T, Chen LH, Kuntzen C, Kitada S, Karin M, Pellecchia M. Design and characterization of a potent and selective dual ATP- and substrate-competitive subnanomolar bidentate c-Jun N-terminal kinase (JNK) inhibitor. Journal of Medicinal Chemistry. 54: 6206-14. PMID 21815634 DOI: 10.1021/jm200479c |
0.317 |
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| 2011 |
Botti E, Spallone G, Moretti F, Marinari B, Pinetti V, Galanti S, De Meo PD, De Nicola F, Ganci F, Castrignanò T, Pesole G, Chimenti S, Guerrini L, Fanciulli M, Blandino G, ... Karin M, et al. Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas. Proceedings of the National Academy of Sciences of the United States of America. 108: 13710-5. PMID 21807998 DOI: 10.1073/pnas.1110931108 |
0.388 |
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| 2011 |
Ben-Neriah Y, Karin M. Inflammation meets cancer, with NF-κB as the matchmaker. Nature Immunology. 12: 715-23. PMID 21772280 DOI: 10.1038/ni.2060 |
0.345 |
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| 2011 |
Ali SR, Timmer AM, Bilgrami S, Park EJ, Eckmann L, Nizet V, Karin M. Anthrax toxin induces macrophage death by p38 MAPK inhibition but leads to inflammasome activation via ATP leakage. Immunity. 35: 34-44. PMID 21683629 DOI: 10.1016/J.Immuni.2011.04.015 |
0.363 |
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| 2011 |
Schmidt T, Kharabi Masouleh B, Loges S, Cauwenberghs S, Fraisl P, Maes C, Jonckx B, De Keersmaecker K, Kleppe M, Tjwa M, Schenk T, Vinckier S, Fragoso R, De Mol M, Beel K, ... ... Karin M, et al. Loss or inhibition of stromal-derived PlGF prolongs survival of mice with imatinib-resistant Bcr-Abl1(+) leukemia. Cancer Cell. 19: 740-53. PMID 21665148 DOI: 10.1016/J.Ccr.2011.05.007 |
0.318 |
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| 2011 |
Häcker H, Tseng PH, Karin M. Expanding TRAF function: TRAF3 as a tri-faced immune regulator. Nature Reviews. Immunology. 11: 457-68. PMID 21660053 DOI: 10.1038/nri2998 |
0.389 |
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| 2011 |
Ashida N, Senbanerjee S, Kodama S, Foo SY, Coggins M, Spencer JA, Zamiri P, Shen D, Li L, Sciuto T, Dvorak A, Gerszten RE, Lin CP, Karin M, Rosenzweig A. IKKβ regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nature Communications. 2: 318. PMID 21587235 DOI: 10.1038/Ncomms1317 |
0.397 |
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| 2011 |
Li N, Grivennikov SI, Karin M. The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment. Cancer Cell. 19: 429-31. PMID 21481782 DOI: 10.1016/j.ccr.2011.03.018 |
0.339 |
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| 2011 |
Kang J, Jiang MH, Min HJ, Jo EK, Lee S, Karin M, Yune TY, Lee SJ. IKK-β-mediated myeloid cell activation exacerbates inflammation and inhibits recovery after spinal cord injury. European Journal of Immunology. 41: 1266-77. PMID 21469085 DOI: 10.1002/eji.201040582 |
0.542 |
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| 2011 |
Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. Crystal structure of inhibitor of κB kinase β. Nature. 472: 325-30. PMID 21423167 DOI: 10.1038/nature09853 |
0.334 |
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| 2011 |
Li L, Ruan Q, Hilliard B, Devirgiliis J, Karin M, Chen YH. Transcriptional regulation of the Th17 immune response by IKK(alpha). The Journal of Experimental Medicine. 208: 787-96. PMID 21402739 DOI: 10.1084/Jem.20091346 |
0.393 |
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| 2011 |
Grivennikov SI, Karin M. Inflammatory cytokines in cancer: tumour necrosis factor and interleukin 6 take the stage. Annals of the Rheumatic Diseases. 70: i104-8. PMID 21339211 DOI: 10.1136/ard.2010.140145 |
0.329 |
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| 2011 |
Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M. Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature. 470: 548-53. PMID 21326202 DOI: 10.1038/Nature09707 |
0.336 |
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| 2011 |
Guma M, Ronacher LM, Firestein GS, Karin M, Corr M. JNK-1 deficiency limits macrophage-mediated antigen-induced arthritis. Arthritis and Rheumatism. 63: 1603-12. PMID 21305529 DOI: 10.1002/art.30271 |
0.356 |
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| 2011 |
Kim S, Karin M. Role of TLR2-dependent inflammation in metastatic progression. Annals of the New York Academy of Sciences. 1217: 191-206. PMID 21276007 DOI: 10.1111/j.1749-6632.2010.05882.x |
0.303 |
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| 2011 |
He G, Karin M. NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Research. 21: 159-68. PMID 21187858 DOI: 10.1038/cr.2010.183 |
0.364 |
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| 2011 |
Österreicher CH, Penz-Österreicher M, Grivennikov SI, Guma M, Koltsova EK, Datz C, Sasik R, Hardiman G, Karin M, Brenner DA. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. Proceedings of the National Academy of Sciences of the United States of America. 108: 308-13. PMID 21173249 DOI: 10.1073/Pnas.1017547108 |
0.32 |
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| 2011 |
Hsu LC, Enzler T, Seita J, Timmer AM, Lee CY, Lai TY, Yu GY, Lai LC, Temkin V, Sinzig U, Aung T, Nizet V, Weissman IL, Karin M. IL-1β-driven neutrophilia preserves antibacterial defense in the absence of the kinase IKKβ. Nature Immunology. 12: 144-50. PMID 21170027 DOI: 10.1038/Ni.1976 |
0.366 |
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| 2011 |
Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H. Crystal structure of inhibitor of kappaB kinase beta. Nature. 472: 325-330. DOI: 10.2210/Pdb3Qa8/Pdb |
0.316 |
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| 2010 |
Guma M, Kashiwakura J, Crain B, Kawakami Y, Beutler B, Firestein GS, Kawakami T, Karin M, Corr M. JNK1 controls mast cell degranulation and IL-1{beta} production in inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America. 107: 22122-7. PMID 21135226 DOI: 10.1073/Pnas.1016401107 |
0.338 |
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| 2010 |
Zhang W, Kater AP, Widhopf GF, Chuang HY, Enzler T, James DF, Poustovoitov M, Tseng PH, Janz S, Hoh C, Herschman H, Karin M, Kipps TJ. B-cell activating factor and v-Myc myelocytomatosis viral oncogene homolog (c-Myc) influence progression of chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 107: 18956-60. PMID 20956327 DOI: 10.1073/Pnas.1013420107 |
0.573 |
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| 2010 |
Budanov AV, Lee JH, Karin M. Stressin' Sestrins take an aging fight. Embo Molecular Medicine. 2: 388-400. PMID 20878915 DOI: 10.1002/emmm.201000097 |
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| 2010 |
Napolitano G, Karin M. Sphingolipids: the oil on the TRAFire that promotes inflammation. Science Signaling. 3: pe34. PMID 20876871 DOI: 10.1126/scisignal.3141pe34 |
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| 2010 |
Doedens AL, Stockmann C, Rubinstein MP, Liao D, Zhang N, DeNardo DG, Coussens LM, Karin M, Goldrath AW, Johnson RS. Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Research. 70: 7465-75. PMID 20841473 DOI: 10.1158/0008-5472.Can-10-1439 |
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| 2010 |
Pérez de Diego R, Sancho-Shimizu V, Lorenzo L, Puel A, Plancoulaine S, Picard C, Herman M, Cardon A, Durandy A, Bustamante J, Vallabhapurapu S, Bravo J, Warnatz K, Chaix Y, Cascarrigny F, ... ... Karin M, et al. Human TRAF3 adaptor molecule deficiency leads to impaired Toll-like receptor 3 response and susceptibility to herpes simplex encephalitis. Immunity. 33: 400-11. PMID 20832341 DOI: 10.1016/j.immuni.2010.08.014 |
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| 2010 |
Tsuchiya Y, Asano T, Nakayama K, Kato T, Karin M, Kamata H. Nuclear IKKbeta is an adaptor protein for IkappaBalpha ubiquitination and degradation in UV-induced NF-kappaB activation. Molecular Cell. 39: 570-82. PMID 20797629 DOI: 10.1016/j.molcel.2010.07.030 |
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| 2010 |
Yang J, Splittgerber R, Yull FE, Kantrow S, Ayers GD, Karin M, Richmond A. Conditional ablation of Ikkb inhibits melanoma tumor development in mice. The Journal of Clinical Investigation. 120: 2563-74. PMID 20530876 DOI: 10.1172/Jci42358 |
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| 2010 |
Lee SY, Miller M, Cho JY, Song DJ, Karin M, Broide DH. Inactivation of I kappaB-kinase-beta dependent genes in airway epithelium reduces tobacco smoke induced acute airway inflammation. International Immunopharmacology. 10: 906-12. PMID 20494824 DOI: 10.1016/j.intimp.2010.05.001 |
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| 2010 |
Terzić J, Grivennikov S, Karin E, Karin M. Inflammation and colon cancer. Gastroenterology. 138: 2101-2114.e5. PMID 20420949 DOI: 10.1053/j.gastro.2010.01.058 |
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| 2010 |
Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, Krieg A, Weiner GJ, Fox BA, Coukos G, Wang E, et al. Cancer and inflammation: promise for biologic therapy. Journal of Immunotherapy (Hagerstown, Md. : 1997). 33: 335-51. PMID 20386472 DOI: 10.1097/Cji.0B013E3181D32E74 |
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| 2010 |
Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 140: 883-99. PMID 20303878 DOI: 10.1016/j.cell.2010.01.025 |
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| 2010 |
He G, Yu GY, Temkin V, Ogata H, Kuntzen C, Sakurai T, Sieghart W, Peck-Radosavljevic M, Leffert HL, Karin M. Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. Cancer Cell. 17: 286-97. PMID 20227042 DOI: 10.1016/j.ccr.2009.12.048 |
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| 2010 |
Ammirante M, Luo JL, Grivennikov S, Nedospasov S, Karin M. B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. Nature. 464: 302-5. PMID 20220849 DOI: 10.1038/nature08782 |
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| 2010 |
Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, Ocorr K, Ellisman MH, Bodmer R, Bier E, Karin M. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science (New York, N.Y.). 327: 1223-8. PMID 20203043 DOI: 10.1126/Science.1182228 |
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Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 140: 197-208. PMID 20141834 DOI: 10.1016/J.Cell.2009.12.052 |
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Jang PG, Namkoong C, Kang GM, Hur MW, Kim SW, Kim GH, Kang Y, Jeon MJ, Kim EH, Lee MS, Karin M, Baik JH, Park JY, Lee KU, Kim YB, et al. NF-kappaB activation in hypothalamic pro-opiomelanocortin neurons is essential in illness- and leptin-induced anorexia. The Journal of Biological Chemistry. 285: 9706-15. PMID 20097762 DOI: 10.1074/Jbc.M109.070706 |
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| 2010 |
Grivennikov SI, Karin M. Inflammation and oncogenesis: a vicious connection. Current Opinion in Genetics & Development. 20: 65-71. PMID 20036794 DOI: 10.1016/j.gde.2009.11.004 |
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Grivennikov SI, Karin M. Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine & Growth Factor Reviews. 21: 11-9. PMID 20018552 DOI: 10.1016/j.cytogfr.2009.11.005 |
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| 2010 |
Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology. 138: 1022-34.e1-10. PMID 19962981 DOI: 10.1053/J.Gastro.2009.11.054 |
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| 2010 |
Tseng PH, Matsuzawa A, Zhang W, Mino T, Vignali DA, Karin M. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nature Immunology. 11: 70-5. PMID 19898473 DOI: 10.1038/Ni.1819 |
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Holzer R, Tran H, Salinas G, Karin M. Abstract 38: Saturated free fatty acids activate a c-Src-JNK1 axis within lipid rafts: Implications for the development of insulin resistance, obesity, and obesity-associated cancer Cancer Research. 70: 38-38. DOI: 10.1158/1538-7445.Am10-38 |
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Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harbor Perspectives in Biology. 1: a000141. PMID 20066113 DOI: 10.1101/cshperspect.a000141 |
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Emmanouil M, Taoufik E, Tseveleki V, Vamvakas SS, Tselios T, Karin M, Lassmann H, Probert L. Neuronal I kappa B kinase beta protects mice from autoimmune encephalomyelitis by mediating neuroprotective and immunosuppressive effects in the central nervous system. Journal of Immunology (Baltimore, Md. : 1950). 183: 7877-89. PMID 20007573 DOI: 10.4049/jimmunol.0900834 |
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Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Yanai A, Ogura K, Karin M, Omata M. Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression. Hepatology (Baltimore, Md.). 50: 1851-60. PMID 19821485 DOI: 10.1002/hep.23199 |
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Enzler T, Kater AP, Zhang W, Widhopf GF, Chuang HY, Lee J, Avery E, Croce CM, Karin M, Kipps TJ. Chronic lymphocytic leukemia of Emu-TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression. Blood. 114: 4469-76. PMID 19755673 DOI: 10.1182/Blood-2009-06-230169 |
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Enzler T, Chang X, Facchinetti V, Melino G, Karin M, Su B, Gallagher E. MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. Journal of Immunology (Baltimore, Md. : 1950). 183: 3831-8. PMID 19710465 DOI: 10.4049/jimmunol.0803412 |
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Darash-Yahana M, Gillespie JW, Hewitt SM, Chen YY, Maeda S, Stein I, Singh SP, Bedolla RB, Peled A, Troyer DA, Pikarsky E, Karin M, Farber JM. The chemokine CXCL16 and its receptor, CXCR6, as markers and promoters of inflammation-associated cancers. Plos One. 4: e6695. PMID 19690611 DOI: 10.1371/journal.pone.0006695 |
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Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Annual Review of Immunology. 27: 693-733. PMID 19302050 DOI: 10.1146/annurev.immunol.021908.132641 |
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Karin M, Gallagher E. TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes. Immunological Reviews. 228: 225-40. PMID 19290931 DOI: 10.1111/j.1600-065X.2008.00755.x |
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Chu WM, Gong X, Li ZW, Takabayashi K, Ouyang HH, Chen Y, Chen DJ, Li GC, Karin M, Raz E. Retraction: DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA. Cell. 136: 565. PMID 19203587 DOI: 10.1016/j.cell.2009.01.022 |
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Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, Vallabhapurapu S, Scheller J, Rose-John S, Cheroutre H, Eckmann L, Karin M. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell. 15: 103-13. PMID 19185845 DOI: 10.1016/J.Ccr.2009.01.001 |
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Koch KS, Maeda S, He G, Karin M, Leffert HL. Targeted deletion of hepatocyte Ikkbeta confers growth advantages. Biochemical and Biophysical Research Communications. 380: 349-54. PMID 19171122 DOI: 10.1016/j.bbrc.2009.01.085 |
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Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL, Karin M. Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 457: 102-6. PMID 19122641 DOI: 10.1038/nature07623 |
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Baud V, Karin M. Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nature Reviews. Drug Discovery. 8: 33-40. PMID 19116625 DOI: 10.1038/nrd2781 |
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Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. The Journal of Biological Chemistry. 284: 862-71. PMID 19001420 DOI: 10.1074/Jbc.M804632200 |
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Marinari B, Ballaro C, Koster MI, Giustizieri ML, Moretti F, Crosti F, Papoutsaki M, Karin M, Alema S, Chimenti S, Roop DR, Costanzo A. IKKalpha is a p63 transcriptional target involved in the pathogenesis of ectodermal dysplasias. The Journal of Investigative Dermatology. 129: 60-9. PMID 18633439 DOI: 10.1038/jid.2008.202 |
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Zhang W, Kater AP, Chuang H, Enzler T, Widhopf GF, James D, Herschman H, Karin M, Kipps TJ. B Cell Activating Factor and c-Myc Regulate the Progression of Chronic Lymphocytic Leukemia. Blood. 114: 359-359. DOI: 10.1182/Blood.V114.22.359.359 |
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Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nature Immunology. 9: 1364-70. PMID 18997792 DOI: 10.1038/ni.1678 |
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Marinari B, Moretti F, Botti E, Giustizieri ML, Descargues P, Giunta A, Stolfi C, Ballaro C, Papoutsaki M, Alemà S, Monteleone G, Chimenti S, Karin M, Costanzo A. The tumor suppressor activity of IKKalpha in stratified epithelia is exerted in part via the TGF-beta antiproliferative pathway. Proceedings of the National Academy of Sciences of the United States of America. 105: 17091-6. PMID 18957551 DOI: 10.1073/pnas.0809288105 |
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Sun B, Karin M. NF-kappaB signaling, liver disease and hepatoprotective agents. Oncogene. 27: 6228-44. PMID 18931690 DOI: 10.1038/onc.2008.300 |
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Stebbins JL, De SK, Machleidt T, Becattini B, Vazquez J, Kuntzen C, Chen LH, Cellitti JF, Riel-Mehan M, Emdadi A, Solinas G, Karin M, Pellecchia M. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proceedings of the National Academy of Sciences of the United States of America. 105: 16809-13. PMID 18922779 DOI: 10.1073/pnas.0805677105 |
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Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell. 135: 61-73. PMID 18854155 DOI: 10.1016/J.Cell.2008.07.043 |
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Cho IH, Hong J, Suh EC, Kim JH, Lee H, Lee JE, Lee S, Kim CH, Kim DW, Jo EK, Lee KE, Karin M, Lee SJ. Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain : a Journal of Neurology. 131: 3019-33. PMID 18819987 DOI: 10.1093/Brain/Awn230 |
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Descargues P, Sil AK, Karin M. IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. The Embo Journal. 27: 2639-47. PMID 18818691 DOI: 10.1038/emboj.2008.196 |
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Hou Y, Li F, Karin M, Ostrowski MC. Analysis of the IKKbeta/NF-kappaB signaling pathway during embryonic angiogenesis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2926-35. PMID 18816823 DOI: 10.1002/Dvdy.21723 |
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Eckmann L, Nebelsiek T, Fingerle AA, Dann SM, Mages J, Lang R, Robine S, Kagnoff MF, Schmid RM, Karin M, Arkan MC, Greten FR. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proceedings of the National Academy of Sciences of the United States of America. 105: 15058-63. PMID 18815378 DOI: 10.1073/pnas.0808216105 |
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Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M. Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology. 135: 1311-21. PMID 18700144 DOI: 10.1053/j.gastro.2008.07.006 |
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Budanov AV, Karin M. p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling. Cell. 134: 451-60. PMID 18692468 DOI: 10.1016/j.cell.2008.06.028 |
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Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 14: 156-65. PMID 18691550 DOI: 10.1016/j.ccr.2008.06.016 |
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Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science (New York, N.Y.). 321: 663-8. PMID 18635759 DOI: 10.1126/Science.1157340 |
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Shibata W, Maeda S, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, Omata M. c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Research. 68: 5031-9. PMID 18593901 DOI: 10.1158/0008-5472.CAN-07-6332 |
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Hsu LC, Ali SR, McGillivray S, Tseng PH, Mariathasan S, Humke EW, Eckmann L, Powell JJ, Nizet V, Dixit VM, Karin M. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proceedings of the National Academy of Sciences of the United States of America. 105: 7803-8. PMID 18511561 DOI: 10.1073/Pnas.0802726105 |
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Fong CH, Bebien M, Didierlaurent A, Nebauer R, Hussell T, Broide D, Karin M, Lawrence T. An antiinflammatory role for IKKbeta through the inhibition of "classical" macrophage activation. The Journal of Experimental Medicine. 205: 1269-76. PMID 18490491 DOI: 10.1084/jem.20080124 |
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Julius C, Heikenwalder M, Schwarz P, Marcel A, Karin M, Prinz M, Pasparakis M, Aguzzi A. Prion propagation in mice lacking central nervous system NF-kappaB signalling. The Journal of General Virology. 89: 1545-50. PMID 18474572 DOI: 10.1099/Vir.0.83622-0 |
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Naugler WE, Karin M. NF-kappaB and cancer-identifying targets and mechanisms. Current Opinion in Genetics & Development. 18: 19-26. PMID 18440219 DOI: 10.1016/j.gde.2008.01.020 |
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Rius J, Guma M, Schachtrup C, Akassoglou K, Zinkernagel AS, Nizet V, Johnson RS, Haddad GG, Karin M. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature. 453: 807-11. PMID 18432192 DOI: 10.1038/Nature06905 |
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Karin M. The IkappaB kinase - a bridge between inflammation and cancer. Cell Research. 18: 334-42. PMID 18301380 DOI: 10.1038/cr.2008.30 |
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Descargues P, Sil AK, Sano Y, Korchynskyi O, Han G, Owens P, Wang XJ, Karin M. IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiation. Proceedings of the National Academy of Sciences of the United States of America. 105: 2487-92. PMID 18268325 DOI: 10.1073/pnas.0712044105 |
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Enzler T, Zhang W, Kater AP, Widhopf GF, Croce CM, Karin M, Kipps TJ. Constitutive Baff Signalling Plays a Key Role in CLL Development by Promoting Tumor Cell Survival Blood. 112: 28-28. DOI: 10.1182/Blood.V112.11.28.28 |
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Maeda S, Shibata W, Hikiba Y, Yanai A, Sakamoto K, Nakagawa H, Ogura K, Karin M, Omata M. S2052 c-Jun Nh2-Terminal Kinase 1 Is a Critical Regulator for the Development of Chemical-Induced Gastric Cancer in Mice Gastroenterology. 134: A-305. DOI: 10.1016/S0016-5085(08)61422-5 |
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Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metabolism. 6: 386-97. PMID 17983584 DOI: 10.1016/J.Cmet.2007.09.011 |
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Temkin V, Karin M. From death receptor to reactive oxygen species and c-Jun N-terminal protein kinase: the receptor-interacting protein 1 odyssey. Immunological Reviews. 220: 8-21. PMID 17979836 DOI: 10.1111/j.1600-065X.2007.00560.x |
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Ruocco MG, Karin M. Control of osteoclast activity and bone loss by IKK subunits: new targets for therapy. Advances in Experimental Medicine and Biology. 602: 125-34. PMID 17966397 DOI: 10.1007/978-0-387-72009-8_16 |
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Karin M. Rsk Tolls the bell for endocytosis in DCs. Nature Immunology. 8: 1197-9. PMID 17952046 DOI: 10.1038/ni1107-1197 |
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Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G. Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry. 46: 12482-90. PMID 17924664 DOI: 10.1021/Bi701137A |
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Cao Y, Luo JL, Karin M. IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumor-initiating cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 15852-7. PMID 17890319 DOI: 10.1073/pnas.0706728104 |
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Greten FR, Arkan MC, Bollrath J, Hsu LC, Goode J, Miething C, Göktuna SI, Neuenhahn M, Fierer J, Paxian S, Van Rooijen N, Xu Y, O'Cain T, Jaffee BB, Busch DH, ... ... Karin M, et al. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell. 130: 918-31. PMID 17803913 DOI: 10.1016/J.Cell.2007.07.009 |
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Lin WW, Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. The Journal of Clinical Investigation. 117: 1175-83. PMID 17476347 DOI: 10.1172/JCI31537 |
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Chen LW, Chen PH, Chang WJ, Wang JS, Karin M, Hsu CM. IKappaB-kinase/nuclear factor-kappaB signaling prevents thermal injury-induced gut damage by inhibiting c-Jun NH2-terminal kinase activation. Critical Care Medicine. 35: 1332-40. PMID 17414734 DOI: 10.1097/01.CCM.0000261891.30360.F0 |
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Mills DM, Bonizzi G, Karin M, Rickert RC. Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals. Proceedings of the National Academy of Sciences of the United States of America. 104: 6359-64. PMID 17404218 DOI: 10.1073/Pnas.0700296104 |
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Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, et al. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy. The Journal of Clinical Investigation. 117: 889-901. PMID 17380205 DOI: 10.1172/Jci30556 |
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Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature. 446: 690-4. PMID 17377533 DOI: 10.1038/Nature05656 |
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Koster MI, Dai D, Marinari B, Sano Y, Costanzo A, Karin M, Roop DR. p63 induces key target genes required for epidermal morphogenesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 3255-60. PMID 17360634 DOI: 10.1073/pnas.0611376104 |
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Zaph C, Troy AE, Taylor BC, Berman-Booty LD, Guild KJ, Du Y, Yost EA, Gruber AD, May MJ, Greten FR, Eckmann L, Karin M, Artis D. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature. 446: 552-6. PMID 17322906 DOI: 10.1038/Nature05590 |
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Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, Kim KW, Sherwin RS, Karin M, Lee MS. NF-kappa B prevents beta cell death and autoimmune diabetes in NOD mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 1913-8. PMID 17267600 DOI: 10.1073/Pnas.0610690104 |
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Lickteig AJ, Slitt AL, Arkan MC, Karin M, Cherrington NJ. Differential regulation of hepatic transporters in the absence of tumor necrosis factor-alpha, interleukin-1beta, interleukin-6, and nuclear factor-kappaB in two models of cholestasis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 402-9. PMID 17151194 DOI: 10.1124/Dmd.106.012138 |
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Gallagher E, Enzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, Janssen E, Gao M, Karin M. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nature Immunology. 8: 57-63. PMID 17143273 DOI: 10.1038/Ni1421 |
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Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, Karin M, Kipps TJ. BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood. 109: 703-10. PMID 16973958 DOI: 10.1182/blood-2006-06-027755 |
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Enzler T, Widhopf GF, Lee J, Zhang W, Croce CM, Karin M, Kipps TJ. BAFF Accelerates Development of Chronic Lymphocytic Leukemia in TCL1 Transgenic Mice. Blood. 110: 1117-1117. DOI: 10.1182/Blood.V110.11.1117.1117 |
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Gallagher E, Enzler T, Matsuzawa A, Karin M. Immunoprecipitation of endogenous MEKK1 and kinase assay Nature Protocols. DOI: 10.1038/Nprot.2007.38 |
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Karin M. Tracking the road from inflammation to cancer: the critical role of IkappaB kinase (IKK). Harvey Lectures. 102: 133-51. PMID 20166567 DOI: 10.1002/9780470593042.Ch7 |
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Karin M. Role for IKK2 in muscle: waste not, want not. The Journal of Clinical Investigation. 116: 2866-8. PMID 17080193 DOI: 10.1172/JCI30268 |
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| 2006 |
Lu Z, Serghides L, Patel SN, Degousee N, Rubin BB, Krishnegowda G, Gowda DC, Karin M, Kain KC. Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model. Journal of Immunology (Baltimore, Md. : 1950). 177: 6344-52. PMID 17056565 DOI: 10.4049/Jimmunol.177.9.6344 |
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| 2006 |
Häcker H, Karin M. Regulation and function of IKK and IKK-related kinases. Science's Stke : Signal Transduction Knowledge Environment. 2006: re13. PMID 17047224 DOI: 10.1126/stke.3572006re13 |
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| 2006 |
Enzler T, Bonizzi G, Silverman GJ, Otero DC, Widhopf GF, Anzelon-Mills A, Rickert RC, Karin M. Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease. Immunity. 25: 403-15. PMID 16973390 DOI: 10.1016/J.Immuni.2006.07.010 |
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| 2006 |
Chen F, Lu Y, Castranova V, Li Z, Karin M. Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells. The Journal of Biological Chemistry. 281: 37142-9. PMID 16966325 DOI: 10.1074/jbc.M603631200 |
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| 2006 |
Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 103: 10741-6. PMID 16818881 DOI: 10.1073/Pnas.0603509103 |
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| 2006 |
Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF. Epithelial cell I kappa B-kinase beta has an important protective role in Clostridium difficile toxin A-induced mucosal injury. Journal of Immunology (Baltimore, Md. : 1950). 177: 1214-20. PMID 16818780 DOI: 10.4049/jimmunol.177.2.1214 |
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| 2006 |
Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proceedings of the National Academy of Sciences of the United States of America. 103: 10544-51. PMID 16807293 DOI: 10.1073/pnas.0603499103 |
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| 2006 |
Labuda T, Christensen JP, Rasmussen S, Bonnesen B, Karin M, Thomsen AR, Odum N. MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells. European Journal of Immunology. 36: 2076-84. PMID 16761309 DOI: 10.1002/eji.200535163 |
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Karin M. Nuclear factor-kappaB in cancer development and progression. Nature. 441: 431-6. PMID 16724054 DOI: 10.1038/nature04870 |
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| 2006 |
Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ. Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. The Journal of Biological Chemistry. 281: 21458-68. PMID 16717090 DOI: 10.1074/Jbc.M603784200 |
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Karin M. NF-kappaB and cancer: mechanisms and targets. Molecular Carcinogenesis. 45: 355-61. PMID 16673382 DOI: 10.1002/mc.20217 |
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| 2006 |
Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M, Liu YC. Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation. The Journal of Clinical Investigation. 116: 1117-26. PMID 16557301 DOI: 10.1172/JCI26858 |
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Karin M, Lawrence T, Nizet V. Innate immunity gone awry: linking microbial infections to chronic inflammation and cancer. Cell. 124: 823-35. PMID 16497591 DOI: 10.1016/J.Cell.2006.02.016 |
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Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 124: 601-13. PMID 16469705 DOI: 10.1016/j.cell.2006.01.021 |
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| 2006 |
Guichard A, Park JM, Cruz-Moreno B, Karin M, Bier E. Anthrax lethal factor and edema factor act on conserved targets in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 103: 3244-9. PMID 16455799 DOI: 10.1073/pnas.0510748103 |
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| 2006 |
Mahieu T, Park JM, Revets H, Pasche B, Lengeling A, Staelens J, Wullaert A, Vanlaere I, Hochepied T, van Roy F, Karin M, Libert C. The wild-derived inbred mouse strain SPRET/Ei is resistant to LPS and defective in IFN-beta production. Proceedings of the National Academy of Sciences of the United States of America. 103: 2292-7. PMID 16455798 DOI: 10.1073/pnas.0510874103 |
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Gallagher E, Gao M, Liu YC, Karin M. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proceedings of the National Academy of Sciences of the United States of America. 103: 1717-22. PMID 16446428 DOI: 10.1073/pnas.0510664103 |
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Häcker H, Redecke V, Blagoev B, Kratchmarova I, Hsu LC, Wang GG, Kamps MP, Raz E, Wagner H, Häcker G, Mann M, Karin M. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature. 439: 204-7. PMID 16306937 DOI: 10.1038/Nature04369 |
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Luo JL, Kamata H, Karin M. The anti-death machinery in IKK/NF-kappaB signaling. Journal of Clinical Immunology. 25: 541-50. PMID 16380818 DOI: 10.1007/s10875-005-8217-6 |
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Briata P, Forcales SV, Ponassi M, Corte G, Chen CY, Karin M, Puri PL, Gherzi R. p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Molecular Cell. 20: 891-903. PMID 16364914 DOI: 10.1016/j.molcel.2005.10.021 |
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| 2005 |
Broide DH, Lawrence T, Doherty T, Cho JY, Miller M, McElwain K, McElwain S, Karin M. Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium. Proceedings of the National Academy of Sciences of the United States of America. 102: 17723-8. PMID 16317067 DOI: 10.1073/pnas.0509235102 |
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Luo JL, Kamata H, Karin M. IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy. The Journal of Clinical Investigation. 115: 2625-32. PMID 16200195 DOI: 10.1172/JCI26322 |
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Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nature Reviews. Immunology. 5: 749-59. PMID 16175180 DOI: 10.1038/nri1703 |
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Park JM, Greten FR, Wong A, Westrick RJ, Arthur JS, Otsu K, Hoffmann A, Montminy M, Karin M. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity. 23: 319-29. PMID 16169504 DOI: 10.1016/J.Immuni.2005.08.010 |
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Gao M, Karin M. Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli. Molecular Cell. 19: 581-93. PMID 16137616 DOI: 10.1016/j.molcel.2005.08.017 |
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Karin M, Gallagher E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. Iubmb Life. 57: 283-95. PMID 16036612 DOI: 10.1080/15216540500097111 |
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Maeda S, Kamata H, Luo JL, Leffert H, Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 121: 977-90. PMID 15989949 DOI: 10.1016/j.cell.2005.04.014 |
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Zhang P, Chan J, Dragoi AM, Gong X, Ivanov S, Li ZW, Chuang TH, Chuang T, Tuthill C, Wan Y, Karin M, Chu WM. Activation of IKK by thymosin alpha1 requires the TRAF6 signalling pathway. Embo Reports. 6: 531-7. PMID 15905851 DOI: 10.1038/Sj.Embor.7400433 |
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Ruocco MG, Maeda S, Park JM, Lawrence T, Hsu LC, Cao Y, Schett G, Wagner EF, Karin M. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. The Journal of Experimental Medicine. 201: 1677-87. PMID 15897281 DOI: 10.1084/Jem.20042081 |
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Lawrence T, Bebien M, Liu GY, Nizet V, Karin M. IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature. 434: 1138-43. PMID 15858576 DOI: 10.1038/Nature03491 |
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Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell. 120: 649-61. PMID 15766528 DOI: 10.1016/j.cell.2004.12.041 |
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Maeda S, Hsu LC, Liu H, Bankston LA, Iimura M, Kagnoff MF, Eckmann L, Karin M. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science (New York, N.Y.). 307: 734-8. PMID 15692052 DOI: 10.1126/Science.1103685 |
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Karin M. Inflammation and cancer: the long reach of Ras. Nature Medicine. 11: 20-1. PMID 15635437 DOI: 10.1038/nm0105-20 |
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Park JM, Ng VH, Maeda S, Rest RF, Karin M. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. The Journal of Experimental Medicine. 200: 1647-55. PMID 15611291 DOI: 10.1084/Jem.20041215 |
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Valledor AF, Hsu LC, Ogawa S, Sawka-Verhelle D, Karin M, Glass CK. Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 101: 17813-8. PMID 15601766 DOI: 10.1073/Pnas.0407749101 |
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| 2004 |
Drayton DL, Bonizzi G, Ying X, Liao S, Karin M, Ruddle NH. I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue. Journal of Immunology (Baltimore, Md. : 1950). 173: 6161-8. PMID 15528353 DOI: 10.4049/Jimmunol.173.10.6161 |
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Karin M. Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs. Annals of the Rheumatic Diseases. 63: ii62-ii64. PMID 15479874 DOI: 10.1136/ard.2004.028274 |
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Bonizzi G, Bebien M, Otero DC, Johnson-Vroom KE, Cao Y, Vu D, Jegga AG, Aronow BJ, Ghosh G, Rickert RC, Karin M. Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. The Embo Journal. 23: 4202-10. PMID 15470505 DOI: 10.1038/Sj.Emboj.7600391 |
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Luo JL, Maeda S, Hsu LC, Yagita H, Karin M. Inhibition of NF-kappaB in cancer cells converts inflammation- induced tumor growth mediated by TNFalpha to TRAIL-mediated tumor regression. Cancer Cell. 6: 297-305. PMID 15380520 DOI: 10.1016/J.Ccr.2004.08.012 |
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Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science (New York, N.Y.). 306: 271-5. PMID 15358865 DOI: 10.1126/science.1099414 |
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Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Molecular Cell. 15: 713-25. PMID 15350216 DOI: 10.1016/J.Molcel.2004.08.028 |
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Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell. 118: 285-96. PMID 15294155 DOI: 10.1016/j.cell.2004.07.013 |
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Lee S, Hong J, Choi SY, Oh SB, Park K, Kim JS, Karin M, Lee SJ. CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation. Journal of Neuroimmunology. 153: 50-63. PMID 15265663 DOI: 10.1016/j.jneuroim.2004.04.013 |
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Li ZW, Rickert RC, Karin M. Genetic dissection of antigen receptor induced-NF-kappaB activation. Molecular Immunology. 41: 701-14. PMID 15220005 DOI: 10.1016/J.Molimm.2004.04.012 |
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Shen HM, Lin Y, Choksi S, Tran J, Jin T, Chang L, Karin M, Zhang J, Liu ZG. Essential roles of receptor-interacting protein and TRAF2 in oxidative stress-induced cell death. Molecular and Cellular Biology. 24: 5914-22. PMID 15199146 DOI: 10.1128/Mcb.24.13.5914-5922.2004 |
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Bonizzi G, Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends in Immunology. 25: 280-8. PMID 15145317 DOI: 10.1016/j.it.2004.03.008 |
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Xia Y, Karin M. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends in Cell Biology. 14: 94-101. PMID 15102441 DOI: 10.1016/j.tcb.2003.12.005 |
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Sil AK, Maeda S, Sano Y, Roop DR, Karin M. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature. 428: 660-4. PMID 15071597 DOI: 10.1038/nature02421 |
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Galijatovic A, Beaton D, Nguyen N, Chen S, Bonzo J, Johnson R, Maeda S, Karin M, Guengerich FP, Tukey RH. The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice. The Journal of Biological Chemistry. 279: 23969-76. PMID 15037607 DOI: 10.1074/Jbc.M400973200 |
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Park JM, Brady H, Ruocco MG, Sun H, Williams D, Lee SJ, Kato T, Richards N, Chan K, Mercurio F, Karin M, Wasserman SA. Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila. Genes & Development. 18: 584-94. PMID 15037551 DOI: 10.1101/gad.1168104 |
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Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 428: 341-5. PMID 15029200 DOI: 10.1038/Nature02405 |
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Greten FR, Karin M. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Letters. 206: 193-9. PMID 15013524 DOI: 10.1016/j.canlet.2003.08.029 |
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Egan LJ, Eckmann L, Greten FR, Chae S, Li ZW, Myhre GM, Robine S, Karin M, Kagnoff MF. IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium. Proceedings of the National Academy of Sciences of the United States of America. 101: 2452-7. PMID 14983030 DOI: 10.1073/PNAS.0306734101 |
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Karin M, Yamamoto Y, Wang QM. The IKK NF-kappa B system: a treasure trove for drug development. Nature Reviews. Drug Discovery. 3: 17-26. PMID 14708018 DOI: 10.1038/nrd1279 |
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Amir RE, Haecker H, Karin M, Ciechanover A. Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene. 23: 2540-7. PMID 14676825 DOI: 10.1038/Sj.Onc.1207366 |
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Omori SA, Li Z, Karin M, Rickert RC. CONTRIBUTIONS OF PI3-KINASE AND NF-KB SIGNALING PATHWAYS IN B LYMPHOCYTE DIFFERENTIATION AND SURVIVAL Shock. 21: 45. DOI: 10.1097/00024382-200403001-00178 |
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Cao Y, Karin M. NF-kappaB in mammary gland development and breast cancer. Journal of Mammary Gland Biology and Neoplasia. 8: 215-23. PMID 14635796 DOI: 10.1023/A:1025905008934 |
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Chen F, Castranova V, Li Z, Karin M, Shi X. Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer Research. 63: 7689-93. PMID 14633691 |
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Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity. 19: 725-37. PMID 14614859 DOI: 10.1016/S1074-7613(03)00301-7 |
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Kato T, Delhase M, Hoffmann A, Karin M. CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Molecular Cell. 12: 829-39. PMID 14580335 DOI: 10.1016/S1097-2765(03)00358-7 |
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Fujita F, Taniguchi Y, Kato T, Narita Y, Furuya A, Ogawa T, Sakurai H, Joh T, Itoh M, Delhase M, Karin M, Nakanishi M. Identification of NAP1, a regulatory subunit of IkappaB kinase-related kinases that potentiates NF-kappaB signaling. Molecular and Cellular Biology. 23: 7780-93. PMID 14560022 DOI: 10.1128/MCB.23.21.7780-7793.2003 |
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Zhang L, Wang W, Hayashi Y, Jester JV, Birk DE, Gao M, Liu CY, Kao WW, Karin M, Xia Y. A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. The Embo Journal. 22: 4443-54. PMID 12941696 DOI: 10.1093/Emboj/Cdg440 |
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Hayakawa M, Miyashita H, Sakamoto I, Kitagawa M, Tanaka H, Yasuda H, Karin M, Kikugawa K. Evidence that reactive oxygen species do not mediate NF-kappaB activation. The Embo Journal. 22: 3356-66. PMID 12839997 DOI: 10.1093/emboj/cdg332 |
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Li ZW, Omori SA, Labuda T, Karin M, Rickert RC. IKK beta is required for peripheral B cell survival and proliferation. Journal of Immunology (Baltimore, Md. : 1950). 170: 4630-7. PMID 12707341 DOI: 10.4049/Jimmunol.170.9.4630 |
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Chen LW, Egan L, Li ZW, Greten FR, Kagnoff MF, Karin M. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nature Medicine. 9: 575-81. PMID 12692538 DOI: 10.1038/nm849 |
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Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Developmental Cell. 4: 521-33. PMID 12689591 DOI: 10.1016/S1534-5807(03)00094-7 |
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Lin A, Karin M. NF-kappaB in cancer: a marked target. Seminars in Cancer Biology. 13: 107-14. PMID 12654254 DOI: 10.1016/S1044-579X(02)00128-1 |
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Chen S, Nguyen N, Tamura K, Karin M, Tukey RH. The role of the Ah receptor and p38 in benzo[a]pyrene-7,8-dihydrodiol and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis. The Journal of Biological Chemistry. 278: 19526-33. PMID 12637498 DOI: 10.1074/Jbc.M300780200 |
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Maeda S, Karin M. Oncogene at last--c-Jun promotes liver cancer in mice. Cancer Cell. 3: 102-4. PMID 12620404 DOI: 10.1016/S1535-6108(03)00025-4 |
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Bayon Y, Ortiz MA, Lopez-Hernandez FJ, Gao F, Karin M, Pfahl M, Piedrafita FJ. Inhibition of IkappaB kinase by a new class of retinoid-related anticancer agents that induce apoptosis. Molecular and Cellular Biology. 23: 1061-74. PMID 12529410 DOI: 10.1128/Mcb.23.3.1061-1074.2003 |
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Shim J, Lim H, R Yates J, Karin M. Nuclear export of NF90 is required for interleukin-2 mRNA stabilization. Molecular Cell. 10: 1331-44. PMID 12504009 DOI: 10.1016/S1097-2765(02)00730-X |
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Häcker H, Karin M. Is NF-kappaB2/p100 a direct activator of programmed cell death? Cancer Cell. 2: 431-3. PMID 12498710 DOI: 10.1016/S1535-6108(02)00213-1 |
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Dejardin E, Droin NM, Delhase M, Haas E, Cao Y, Makris C, Li ZW, Karin M, Ware CF, Green DR. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 17: 525-35. PMID 12387745 DOI: 10.1016/S1074-7613(02)00423-5 |
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Park JM, Greten FR, Li ZW, Karin M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science (New York, N.Y.). 297: 2048-51. PMID 12202685 DOI: 10.1126/science.1073163 |
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Makris C, Roberts JL, Karin M. The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Molecular and Cellular Biology. 22: 6573-81. PMID 12192055 DOI: 10.1128/MCB.22.18.6573-6581.2002 |
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Takanami-Ohnishi Y, Amano S, Kimura S, Asada S, Utani A, Maruyama M, Osada H, Tsunoda H, Irukayama-Tomobe Y, Goto K, Karin M, Sudo T, Kasuya Y. Essential role of p38 mitogen-activated protein kinase in contact hypersensitivity. The Journal of Biological Chemistry. 277: 37896-903. PMID 12138127 DOI: 10.1074/jbc.M207326200 |
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Wang L, Lee YK, Bundman D, Han Y, Thevananther S, Kim CS, Chua SS, Wei P, Heyman RA, Karin M, Moore DD. Redundant pathways for negative feedback regulation of bile acid production. Developmental Cell. 2: 721-31. PMID 12062085 DOI: 10.1016/S1534-5807(02)00187-9 |
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Karin M, Cao Y, Greten FR, Li ZW. NF-kappaB in cancer: from innocent bystander to major culprit. Nature Reviews. Cancer. 2: 301-10. PMID 12001991 DOI: 10.1038/nrc780 |
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Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nature Cell Biology. 4: E131-6. PMID 11988758 DOI: 10.1038/ncb0502-e131 |
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Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell. 109: S81-96. PMID 11983155 DOI: 10.1016/S0092-8674(02)00703-1 |
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Yoshida K, Behrens A, Le-Niculescu H, Wagner EF, Harada T, Imaki J, Ohno S, Karin M. Amino-terminal phosphorylation of c-Jun regulates apoptosis in the retinal ganglion cells by optic nerve transection. Investigative Ophthalmology & Visual Science. 43: 1631-5. PMID 11980884 |
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Han Z, Chang L, Yamanishi Y, Karin M, Firestein GS. Joint damage and inflammation in c-Jun N-terminal kinase 2 knockout mice with passive murine collagen-induced arthritis. Arthritis and Rheumatism. 46: 818-23. PMID 11920420 DOI: 10.1002/art.10104 |
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Senftleben U, Karin M. The IKK/NF-kappaB pathway. Critical Care Medicine. 30: S18-S26. PMID 11891403 DOI: 10.1097/00003246-200201001-00003 |
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Karin M, Lin A. NF-kappaB at the crossroads of life and death. Nature Immunology. 3: 221-7. PMID 11875461 DOI: 10.1038/Ni0302-221 |
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Karin M, Takahashi T, Kapahi P, Delhase M, Chen Y, Makris C, Rothwarf D, Baud V, Natoli G, Guido F, Li N. Oxidative stress and gene expression: the AP-1 and NF-kappaB connections. Biofactors (Oxford, England). 15: 87-9. PMID 12016332 DOI: 10.1002/Biof.5520150207 |
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Cao Y, Bonizzi G, Seagroves TN, Greten FR, Johnson R, Schmidt EV, Karin M. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 107: 763-75. PMID 11747812 DOI: 10.1016/S0092-8674(01)00599-2 |
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Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. Inhibition of JNK activation through NF-kappaB target genes. Nature. 414: 313-7. PMID 11713531 DOI: 10.1038/35104568 |
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| 2001 |
Senftleben U, Cao Y, Xiao G, Greten FR, Krähn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M. Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science (New York, N.Y.). 293: 1495-9. PMID 11520989 DOI: 10.1126/Science.1062677 |
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| 2001 |
Baud V, Karin M. Signal transduction by tumor necrosis factor and its relatives. Trends in Cell Biology. 11: 372-7. PMID 11514191 DOI: 10.1016/S0962-8924(01)02064-5 |
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| 2001 |
Ojo-Amaize EA, Kapahi P, Kakkanaiah VN, Takahashi T, Shalom-Barak T, Cottam HB, Adesomoju AA, Nchekwube EJ, Oyemade OA, Karin M, Okogun JI. Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase. Cellular Immunology. 209: 149-57. PMID 11446747 DOI: 10.1006/Cimm.2001.1798 |
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| 2001 |
Han Z, Boyle DL, Chang L, Bennett B, Karin M, Yang L, Manning AM, Firestein GS. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. The Journal of Clinical Investigation. 108: 73-81. PMID 11435459 DOI: 10.1172/JCI12466 |
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| 2001 |
Jiménez B, Volpert OV, Reiher F, Chang L, Muñoz A, Karin M, Bouck N. c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1. Oncogene. 20: 3443-8. PMID 11423995 DOI: 10.1038/Sj.Onc.1204464 |
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| 2001 |
Shaulian E, Karin M. AP-1 in cell proliferation and survival. Oncogene. 20: 2390-400. PMID 11402335 DOI: 10.1038/sj.onc.1204383 |
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Karin M, Chang L. AP-1--glucocorticoid receptor crosstalk taken to a higher level. The Journal of Endocrinology. 169: 447-51. PMID 11375114 DOI: 10.1677/JOE.0.1690447 |
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| 2001 |
Devin A, Lin Y, Yamaoka S, Li Z, Karin M. The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Molecular and Cellular Biology. 21: 3986-94. PMID 11359906 DOI: 10.1128/MCB.21.12.3986-3994.2001 |
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| 2001 |
Senftleben U, Li Z, Baud V, Karin M. IKKβ Is Essential for Protecting T Cells from TNFα-Induced Apoptosis Immunity. 14: 217-230. PMID 11290332 DOI: 10.1016/S1074-7613(01)00104-2 |
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| 2001 |
Hu Y, Baud V, Oga T, Kim KI, Yoshida K, Karin M. IKKalpha controls formation of the epidermis independently of NF-kappaB. Nature. 410: 710-4. PMID 11287960 DOI: 10.1038/35070605 |
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| 2001 |
Piu F, Aronheim A, Katz S, Karin M. AP-1 repressor protein JDP-2: inhibition of UV-mediated apoptosis through p53 down-regulation. Molecular and Cellular Biology. 21: 3012-24. PMID 11287607 DOI: 10.1128/MCB.21.9.3012-3024.2001 |
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| 2001 |
Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 410: 37-40. PMID 11242034 DOI: 10.1038/35065000 |
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| 2001 |
Cavalli V, Vilbois F, Corti M, Marcote MJ, Tamura K, Karin M, Arkinstall S, Gruenberg J. The stress-induced MAP kinase p38 regulates endocytic trafficking via the GDI:Rab5 complex. Molecular Cell. 7: 421-32. PMID 11239470 DOI: 10.1016/S1097-2765(01)00189-7 |
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| 2001 |
Delhase M, Karin M. The I kappa B kinase: a master regulator of NF-kappa B, innate immunity, and epidermal differentiation. Cold Spring Harbor Symposia On Quantitative Biology. 64: 491-503. PMID 11232326 DOI: 10.1101/SQB.1999.64.491 |
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| 2001 |
Sabapathy K, Kallunki T, David JP, Graef I, Karin M, Wagner EF. c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. The Journal of Experimental Medicine. 193: 317-28. PMID 11157052 DOI: 10.1084/Jem.193.3.317 |
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Feng W, Webb P, Nguyen P, Liu X, Li J, Karin M, Kushner PJ. Potentiation of estrogen receptor activation function 1 (AF-1) by Src/JNK through a serine 118-independent pathway Molecular Endocrinology. 15: 32-45. PMID 11145737 DOI: 10.1210/MEND.15.1.0590 |
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| 2001 |
Shaulian E, Schreiber M, Piu F, Beeche M, Wagner EF, Karin M. The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell. 103: 897-907. PMID 11136975 DOI: 10.1016/S0092-8674(00)00193-8 |
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| 2000 |
Li N, Banin S, Ouyang H, Li GC, Courtois G, Shiloh Y, Karin M, Rotman G. ATM is required for IkappaB kinase (IKKk) activation in response to DNA double strand breaks. The Journal of Biological Chemistry. 276: 8898-903. PMID 11114307 DOI: 10.1074/jbc.M009809200 |
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| 2000 |
Kapahi P, Takahashi T, Natoli G, Adams SR, Chen Y, Tsien RY, Karin M. Inhibition of NF-kappa B activation by arsenite through reaction with a critical cysteine in the activation loop of Ikappa B kinase. The Journal of Biological Chemistry. 275: 36062-6. PMID 10967126 DOI: 10.1074/Jbc.M007204200 |
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| 2000 |
Tamura K, Sudo T, Senftleben U, Dadak AM, Johnson R, Karin M. Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. Cell. 102: 221-31. PMID 10943842 DOI: 10.1016/S0092-8674(00)00027-1 |
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Delhase M, Li N, Karin M. Kinase regulation in inflammatory response. Nature. 406: 367-8. PMID 10935625 DOI: 10.1038/35019154 |
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Sudo T, Karin M. Assays for JNK and p38 mitogen-activated protein kinases. Methods in Enzymology. 322: 388-92. PMID 10914034 DOI: 10.1016/S0076-6879(00)22037-5 |
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| 2000 |
Makris C, Godfrey VL, Krähn-Senftleben G, Takahashi T, Roberts JL, Schwarz T, Feng L, Johnson RS, Karin M. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Molecular Cell. 5: 969-79. PMID 10911991 DOI: 10.1016/S1097-2765(00)80262-2 |
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| 2000 |
Li N, Karin M. Signaling pathways leading to nuclear factor-kappa B activation. Methods in Enzymology. 319: 273-9. PMID 10907518 DOI: 10.1016/S0076-6879(00)19027-5 |
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Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annual Review of Immunology. 18: 621-63. PMID 10837071 DOI: 10.1146/annurev.immunol.18.1.621 |
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| 2000 |
Xia Y, Makris C, Su B, Li E, Yang J, Nemerow GR, Karin M. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration Proceedings of the National Academy of Sciences of the United States of America. 97: 5243-5248. PMID 10805784 DOI: 10.1073/Pnas.97.10.5243 |
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| 2000 |
Wu Z, Woodring PJ, Bhakta KS, Tamura K, Wen F, Feramisco JR, Karin M, Wang JY, Puri PL. p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Molecular and Cellular Biology. 20: 3951-64. PMID 10805738 DOI: 10.1128/Mcb.20.11.3951-3964.2000 |
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| 2000 |
López-Fernández J, Palacios D, Castillo AI, Tolon RM, Aranda A, Karin M. Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2. The Journal of Biological Chemistry. 275: 21653-60. PMID 10801832 DOI: 10.1074/JBC.M002129200 |
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Tojima Y, Fujimoto A, Delhase M, Chen Y, Hatakeyama S, Nakayama K, Kaneko Y, Nimura Y, Motoyama N, Ikeda K, Karin M, Nakanishi M. NAK is an IkappaB kinase-activating kinase. Nature. 404: 778-82. PMID 10783893 DOI: 10.1038/35008109 |
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Karin M, Delhase M. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Seminars in Immunology. 12: 85-98. PMID 10723801 DOI: 10.1006/SMIM.2000.0210 |
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| 2000 |
Puri PL, Wu Z, Zhang P, Wood LD, Bhakta KS, Han J, Feramisco JR, Karin M, Wang JY. Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes & Development. 14: 574-84. PMID 10716945 DOI: 10.1101/Gad.14.5.574 |
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| 2000 |
Cheng J, Yang J, Xia Y, Karin M, Su B. Synergistic interaction of MEK kinase 2, c-Jun N-terminal kinase (JNK) kinase 2, and JNK1 results in efficient and specific JNK1 activation. Molecular and Cellular Biology. 20: 2334-42. PMID 10713157 DOI: 10.1128/MCB.20.7.2334-2342.2000 |
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| 2000 |
Rossi A, Kapahi P, Natoli G, Takahashi T, Chen Y, Karin M, Santoro MG. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature. 403: 103-8. PMID 10638762 DOI: 10.1038/47520 |
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| 2000 |
Chu WM, Ostertag D, Li ZW, Chang L, Chen Y, Hu Y, Williams B, Perrault J, Karin M. JNK2 and IKKbeta are required for activating the innate response to viral infection. Immunity. 11: 721-31. PMID 10626894 DOI: 10.1016/S1074-7613(00)80146-6 |
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| 2000 |
Karin M. How NF-kappaB is activated: the role of the IkappaB kinase (IKK) complex. Oncogene. 18: 6867-74. PMID 10602462 DOI: 10.1038/sj.onc.1203219 |
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Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mechanisms of Development. 89: 115-24. PMID 10559486 DOI: 10.1016/S0925-4773(99)00213-0 |
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| 2000 |
Schreiber M, Piu F, Kolbus A, Szabowski A, Möhle-Steinlein U, Tian J, Karin M, Angel P, Wagner E. Negative regulation of p53 expression is an essential, rate-limiting function of Jun in the control of cell cycle progression Breast Cancer Research. 2. DOI: 10.1186/Bcr167 |
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| 2000 |
Chen CY, Gherzi R, Andersen JS, Gaietta G, Jürchott K, Royer HD, Mann M, Karin M. Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation Genes & Development. 14: 1236-1248. DOI: 10.1101/Gad.14.10.1236 |
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| 1999 |
Rothwarf DM, Karin M. The NF-kappa B activation pathway: a paradigm in information transfer from membrane to nucleus. Science's Stke : Signal Transduction Knowledge Environment. 1999: RE1. PMID 11865184 DOI: 10.1126/stke.1999.5.re1 |
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| 1999 |
Shaulian E, Karin M. Stress-induced JNK activation is independent of Gadd45 induction. The Journal of Biological Chemistry. 274: 29595-8. PMID 10514425 DOI: 10.1074/jbc.274.42.29595 |
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Karin M. The beginning of the end: IkappaB kinase (IKK) and NF-kappaB activation. The Journal of Biological Chemistry. 274: 27339-42. PMID 10488062 DOI: 10.1074/jbc.274.39.27339 |
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Zandi E, Karin M. Bridging the gap: Composition, regulation, and physiological function of the IκB kinase complex Molecular and Cellular Biology. 19: 4547-4551. PMID 10373503 DOI: 10.1128/Mcb.19.7.4547 |
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Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M. The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. The Journal of Experimental Medicine. 189: 1839-45. PMID 10359587 DOI: 10.1084/Jem.189.11.1839 |
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| 1999 |
Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain. Genes & Development. 13: 1297-308. PMID 10346818 DOI: 10.1101/GAD.13.10.1297 |
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| 1999 |
Tian J, Karin M. Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin). The Journal of Biological Chemistry. 274: 15173-80. PMID 10329725 DOI: 10.1074/jbc.274.21.15173 |
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Hu Y, Baud V, Delhase M, Zhang P, Deerinck T, Ellisman M, Johnson R, Karin M. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase. Science (New York, N.Y.). 284: 316-20. PMID 10195896 DOI: 10.1126/Science.284.5412.316 |
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| 1999 |
Delhase M, Hayakawa M, Chen Y, Karin M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science (New York, N.Y.). 284: 309-13. PMID 10195894 DOI: 10.1126/SCIENCE.284.5412.309 |
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| 1999 |
Schreiber M, Kolbus A, Piu F, Szabowski A, Möhle-Steinlein U, Tian J, Karin M, Angel P, Wagner EF. Control of cell cycle progression by c-Jun is p53 dependent. Genes & Development. 13: 607-19. PMID 10072388 DOI: 10.1101/Gad.13.5.607 |
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| 1999 |
Sabapathy K, Hu Y, Kallunki T, Schreiber M, David JP, Jochum W, Wagner EF, Karin M. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Current Biology : Cb. 9: 116-25. PMID 10021384 DOI: 10.1016/S0960-9822(99)80065-7 |
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| 1999 |
Hettmann T, DiDonato J, Karin M, Leiden JM. An essential role for nuclear factor kappaB in promoting double positive thymocyte apoptosis. The Journal of Experimental Medicine. 189: 145-58. PMID 9874571 DOI: 10.1084/jem.189.1.145 |
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| 1999 |
Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Molecular and Cellular Biology. 19: 751-63. PMID 9858598 DOI: 10.1128/Mcb.19.1.751 |
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| 1999 |
Li N, Karin M. Is NF‐κB the sensor of oxidative stress? The Faseb Journal. 13: 1137-1143. DOI: 10.1096/fasebj.13.10.1137 |
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| 1998 |
Xia Y, Wu Z, Su B, Murray B, Karin M. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes & Development. 12: 3369-81. PMID 9808624 DOI: 10.1101/Gad.12.21.3369 |
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| 1998 |
Li N, Karin M. Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 95: 13012-7. PMID 9789032 DOI: 10.1073/PNAS.95.22.13012 |
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| 1998 |
Rothwarf DM, Zandi E, Natoli G, Karin M. IKK-γ is an essential regulatory subunit of the IκB kinase complex Nature. 395: 297-300. PMID 9751060 DOI: 10.1038/26261 |
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| 1998 |
Zandi E, Chen Y, Karin M. Direct phosphorylation of IκB by IKKα and IKKβ: Discrimination between free and NF-κB-bound substrate Science. 281: 1360-1363. PMID 9721103 DOI: 10.1126/Science.281.5381.1360 |
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| 1998 |
Uhlik M, Good L, Xiao G, Harhaj EW, Zandi E, Karin M, Sun SC. NF-κB-inducing kinase and IκB kinase participate in human T-cell leukemia virus I tax-mediated NF-κB activation Journal of Biological Chemistry. 273: 21132-21136. PMID 9694868 DOI: 10.1074/Jbc.273.33.21132 |
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| 1998 |
Karin M, Delhase M. JNK or IKK, AP-1 or NF-kappaB, which are the targets for MEK kinase 1 action? Proceedings of the National Academy of Sciences of the United States of America. 95: 9067-9. PMID 9689033 DOI: 10.1073/PNAS.95.16.9067 |
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| 1998 |
Karin M. Mitogen-activated protein kinase cascades as regulators of stress responses. Annals of the New York Academy of Sciences. 851: 139-46. PMID 9668616 DOI: 10.1111/j.1749-6632.1998.tb08987.x |
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| 1998 |
Chen CY, Del Gatto-Konczak F, Wu Z, Karin M. Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science (New York, N.Y.). 280: 1945-9. PMID 9632395 DOI: 10.1126/Science.280.5371.1945 |
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| 1998 |
Werlen G, Jacinto E, Xia Y, Karin M. Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. The Embo Journal. 17: 3101-11. PMID 9606192 DOI: 10.1093/emboj/17.11.3101 |
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| 1998 |
Karin M. New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable? Cell. 93: 487-90. PMID 9604923 DOI: 10.1016/S0092-8674(00)81177-0 |
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| 1998 |
Jacinto E, Werlen G, Karin M. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity. 8: 31-41. PMID 9462509 DOI: 10.1016/S1074-7613(00)80456-2 |
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| 1998 |
Herdegen T, Claret F, Kallunki T, Martin-Villalba A, Winter C, Hunter T, Karin M. Lasting N-Terminal Phosphorylation of c-Jun and Activation of c-Jun N-Terminal Kinases after Neuronal Injury The Journal of Neuroscience. 18: 5124-5135. DOI: 10.1523/Jneurosci.18-14-05124.1998 |
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| 1997 |
Wu Z, Wu J, Jacinto E, Karin M. Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase. Molecular and Cellular Biology. 17: 7407-16. PMID 9372971 DOI: 10.1128/Mcb.17.12.7407 |
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| 1997 |
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for Iκb phosphorylation and NF-κB activation Cell. 91: 243-252. PMID 9346241 DOI: 10.1016/S0092-8674(00)80406-7 |
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| 1997 |
Didonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB Nature. 388: 548-554. PMID 9252186 DOI: 10.1038/41493 |
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| 1997 |
Saatcioglu F, Lopez G, West BL, Zandi E, Feng W, Lu H, Esmaili A, Apriletti JW, Kushner PJ, Baxter JD, Karin M. Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity. Molecular and Cellular Biology. 17: 4687-95. PMID 9234725 DOI: 10.1128/Mcb.17.8.4687 |
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| 1997 |
Aronheim A, Zandi E, Hennemann H, Elledge SJ, Karin M. Isolation of an AP-1 repressor by a novel method for detecting protein- protein interactions Molecular and Cellular Biology. 17: 3094-3102. PMID 9154808 DOI: 10.1128/Mcb.17.6.3094 |
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| 1997 |
Karin M, Liu ZG, Zandi E. AP-1 function and regulation Current Opinion in Cell Biology. 9: 240-246. PMID 9069263 DOI: 10.1016/S0955-0674(97)80068-3 |
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| 1997 |
Kallunki T, Deng T, Hibi M, Karin M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell. 87: 929-39. PMID 8945519 DOI: 10.1016/S0092-8674(00)81999-6 |
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| 1997 |
Su B, Karin M. Mitogen-activated protein kinase cascades and regulation of gene expression. Current Opinion in Immunology. 8: 402-11. PMID 8793994 DOI: 10.1016/S0952-7915(96)80131-2 |
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| 1996 |
Reach M, Galindo RL, Towb P, Allen JL, Karin M, Wasserman SA. A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Developmental Biology. 180: 353-64. PMID 8948598 DOI: 10.1006/dbio.1996.0308 |
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| 1996 |
Liu ZG, Baskaran R, Lea-Chou ET, Wood LD, Chen Y, Karin M, Wang JY. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature. 384: 273-6. PMID 8918879 DOI: 10.1038/384273a0 |
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| 1996 |
Liu ZG, Hsu H, Goeddel DV, Karin M. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Cell. 87: 565-76. PMID 8898208 DOI: 10.1016/S0092-8674(00)81375-6 |
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| 1996 |
Rosette C, Karin M. Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science (New York, N.Y.). 274: 1194-7. PMID 8895468 DOI: 10.1126/science.274.5290.1194 |
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| 1996 |
Li YS, Shyy JY, Li S, Lee J, Su B, Karin M, Chien S. The Ras-JNK pathway is involved in shear-induced gene expression. Molecular and Cellular Biology. 16: 5947-54. PMID 8887624 DOI: 10.1128/Mcb.16.11.5947 |
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| 1996 |
Claret FX, Hibi M, Dhut S, Toda T, Karin M. A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature. 383: 453-7. PMID 8837781 DOI: 10.1038/383453A0 |
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| 1996 |
Didonato JA, Saatcioglu F, Karin M. Molecular mechanisms of immunosuppression and anti-inflammatory activities by glucocorticoids. American Journal of Respiratory and Critical Care Medicine. 154: S11-5. PMID 8756781 DOI: 10.1164/ajrccm/154.2_Pt_2.S11 |
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| 1996 |
Collins LR, Minden A, Karin M, Brown JH. Galpha12 stimulates c-Jun NH2-terminal kinase through the small G proteins Ras and Rac. The Journal of Biological Chemistry. 271: 17349-53. PMID 8663428 DOI: 10.1074/jbc.271.29.17349 |
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| 1996 |
DiDonato J, Mercurio F, Rosette C, Wu-Li J, Suyang H, Ghosh S, Karin M. Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation. Molecular and Cellular Biology. 16: 1295-304. PMID 8657102 DOI: 10.1128/MCB.16.4.1295 |
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| 1996 |
Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 127-34. PMID 8650258 DOI: 10.1098/RSTB.1996.0008 |
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| 1996 |
Johnson NL, Gardner AM, Diener KM, Lange-Carter CA, Gleavy J, Jarpe MB, Minden A, Karin M, Zon LI, Johnson GL. Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. The Journal of Biological Chemistry. 271: 3229-37. PMID 8621725 DOI: 10.1074/Jbc.271.6.3229 |
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| 1996 |
Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, Karin M. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. The Embo Journal. 15: 6269-6279. DOI: 10.1002/j.1460-2075.1996.tb01017.x |
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| 1995 |
Caelles C, Hennemann H, Karin M. M-phase-specific phosphorylation of the POU transcription factor GHF-1 by a cell cycle-regulated protein kinase inhibits DNA binding. Molecular and Cellular Biology. 15: 6694-6701. PMID 8524234 DOI: 10.1128/Mcb.15.12.6694 |
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| 1995 |
Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes & Development. 8: 2996-3007. PMID 8001819 DOI: 10.1101/Gad.8.24.2996 |
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| 1995 |
Rosette C, Karin M. Cytoskeletal control of gene expression: depolymerization of microtubules activates NF-kappa B. The Journal of Cell Biology. 128: 1111-9. PMID 7896875 DOI: 10.1083/JCB.128.6.1111 |
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| 1995 |
DiDonato JA, Mercurio F, Karin M. Phosphorylation of I kappa B alpha precedes but is not sufficient for its dissociation from NF-kappa B. Molecular and Cellular Biology. 15: 1302-11. PMID 7862124 DOI: 10.1128/MCB.15.3.1302 |
0.317 |
|
| 1995 |
Yoshioka K, Deng T, Cavigelli M, Karin M. Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression. Proceedings of the National Academy of Sciences of the United States of America. 92: 4972-6. PMID 7761434 DOI: 10.1073/PNAS.92.11.4972 |
0.362 |
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| 1995 |
Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, Johnson GL, Karin M. Identification of a dual specificity kinase that activates the jun kinases and p38-Mpk2 Science. 268: 286-290. PMID 7716521 DOI: 10.1126/Science.7716521 |
0.374 |
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| 1995 |
Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. The Journal of Biological Chemistry. 270: 16483-6. PMID 7622446 DOI: 10.1074/JBC.270.28.16483 |
0.392 |
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| 1995 |
Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascadeand c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs Cell. 81: 1147-1157. PMID 7600582 DOI: 10.1016/S0092-8674(05)80019-4 |
0.427 |
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| 1995 |
Karin M, Hunter T. Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus. Current Biology : Cb. 5: 747-57. PMID 7583121 DOI: 10.1016/S0960-9822(95)00151-5 |
0.382 |
|
| 1995 |
Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science (New York, N.Y.). 270: 286-90. PMID 7569976 DOI: 10.1126/science.270.5234.286 |
0.379 |
|
| 1995 |
Helmberg A, Auphan N, Caelles C, Karin M. Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. The Embo Journal. 14: 452-460. DOI: 10.1002/j.1460-2075.1995.tb07021.x |
0.358 |
|
| 1995 |
Cavigelli M, Dolfi F, Claret FX, Karin M. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation. The Embo Journal. 14: 5957-5964. DOI: 10.1002/j.1460-2075.1995.tb00284.x |
0.415 |
|
| 1994 |
Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell. 77: 727-36. PMID 8205621 DOI: 10.1016/0092-8674(94)90056-6 |
0.369 |
|
| 1994 |
Trautwein C, van der Geer P, Karin M, Hunter T, Chojkier M. Protein kinase A and C site-specific phosphorylations of LAP (NF-IL6) modulate its binding affinity to DNA recognition elements. The Journal of Clinical Investigation. 93: 2554-61. PMID 8200992 DOI: 10.1172/Jci117266 |
0.349 |
|
| 1994 |
Engelberg D, Klein C, Martinetto H, Struhl K, Karin M. The UV response involving the ras signaling pathway and AP-1 transcription factors is conserved between yeast and mammals Cell. 77: 381-390. PMID 8181058 DOI: 10.1016/0092-8674(94)90153-8 |
0.326 |
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| 1994 |
Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, Karin M, Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell. 76: 1025-37. PMID 8137421 DOI: 10.1016/0092-8674(94)90380-8 |
0.419 |
|
| 1994 |
Theill LE, Karin M. Transcriptional control of GH expression and anterior pituitary development. Endocrine Reviews. 14: 670-89. PMID 8119232 DOI: 10.1210/EDRV-14-6-670 |
0.339 |
|
| 1994 |
Deng T, Karin M. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature. 371: 171-5. PMID 8072547 DOI: 10.1038/371171A0 |
0.383 |
|
| 1994 |
Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 370: 226-9. PMID 8028671 DOI: 10.1038/370226A0 |
0.422 |
|
| 1994 |
Caelles C, Helmberg A, Karin M. p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes. Nature. 370: 220-3. PMID 8028670 DOI: 10.1038/370220A0 |
0.327 |
|
| 1994 |
Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M, Karin M, Brenner DA. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases Proceedings of the National Academy of Sciences of the United States of America. 91: 6030-6034. PMID 8016110 DOI: 10.1073/Pnas.91.13.6030 |
0.366 |
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| 1994 |
Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, Johnson GL, Karin M. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK Science. 266: 1719-1723. PMID 7992057 DOI: 10.1126/Science.7992057 |
0.387 |
|
| 1994 |
Minden A, Lin A, Smeal T, Dérijard B, Cobb M, Davis R, Karin M. c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases Molecular and Cellular Biology. 14: 6683-6688. PMID 7935387 DOI: 10.1128/mcb.14.10.6683-6688.1994 |
0.377 |
|
| 1994 |
Aronheim A, Engelberg D, Li N, al-Alawi N, Schlessinger J, Karin M. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway. Cell. 78: 949-61. PMID 7923364 DOI: 10.1016/0092-8674(94)90271-2 |
0.312 |
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| 1994 |
Karin M. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Current Opinion in Cell Biology. 6: 415-24. PMID 7917334 DOI: 10.1016/0955-0674(94)90035-3 |
0.392 |
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| 1994 |
Saatcioglu F, Deng T, Karin M. A novel cis element mediating ligand-independent activation by c-ErbA: implications for hormonal regulation. Cell. 75: 1095-105. PMID 7903219 DOI: 10.1016/0092-8674(93)90319-L |
0.307 |
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| 1994 |
Smeal T, Hibi M, Karin M. Altering the specificity of signal transduction cascades: positive regulation of c-Jun transcriptional activity by protein kinase A. The Embo Journal. 13: 6006-6010. DOI: 10.1002/j.1460-2075.1994.tb06946.x |
0.405 |
|
| 1993 |
Mercurio F, DiDonato JA, Rosette C, Karin M. p105 and p98 precursor proteins play an active role in NF-kappa B-mediated signal transduction. Genes & Development. 7: 705-18. PMID 8458581 DOI: 10.1101/gad.7.4.705 |
0.326 |
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| 1993 |
Hattori M, Tugores A, Westwick JK, Veloz L, Leffert HL, Karin M, Brenner DA. Activation of activating protein 1 during hepatic acute phase response. The American Journal of Physiology. 264: G95-103. PMID 8430810 DOI: 10.1152/Ajpgi.1993.264.1.G95 |
0.371 |
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| 1993 |
Ekström TJ, Klump WM, Getman D, Karin M, Taylor P. Promoter elements and transcriptional regulation of the acetylcholinesterase gene. Dna and Cell Biology. 12: 63-72. PMID 8422273 DOI: 10.1089/Dna.1993.12.63 |
0.339 |
|
| 1993 |
Alberts AS, Deng T, Lin A, Meinkoth JL, Schönthal A, Mumby MC, Karin M, Feramisco JR. Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements. Molecular and Cellular Biology. 13: 2104-12. PMID 8384305 DOI: 10.1128/Mcb.13.4.2104 |
0.397 |
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| 1993 |
Deng T, Karin M. JunB differs from c-Jun in its DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes & Development. 7: 479-90. PMID 8383624 DOI: 10.1101/GAD.7.3.479 |
0.334 |
|
| 1993 |
Devary Y, Rosette C, DiDonato JA, Karin M. NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science (New York, N.Y.). 261: 1442-5. PMID 8367725 DOI: 10.1126/science.8367725 |
0.381 |
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| 1993 |
Trautwein C, Caelles C, van der Geer P, Hunter T, Karin M, Chojkier M. Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature. 364: 544-7. PMID 8336793 DOI: 10.1038/364544A0 |
0.328 |
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| 1993 |
Karin M, Yang-Yen HF, Chambard JC, Deng T, Saatcioglu F. Various modes of gene regulation by nuclear receptors for steroid and thyroid hormones. European Journal of Clinical Pharmacology. 45. PMID 8313934 DOI: 10.1007/Bf01844197 |
0.418 |
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| 1993 |
Hibi M, Lin A, Smeal T, Minden A, Karin M. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain Genes and Development. 7: 2135-2148. PMID 8224842 DOI: 10.1101/Gad.7.11.2135 |
0.379 |
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| 1993 |
Saatcioglu F, Bartunek P, Deng T, Zenke M, Karin M. A conserved C-terminal sequence that is deleted in v-ErbA is essential for the biological activities of c-ErbA (the thyroid hormone receptor). Molecular and Cellular Biology. 13: 3675-85. PMID 8098843 DOI: 10.1128/MCB.13.6.3675 |
0.311 |
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| 1993 |
Lew D, Brady H, Klausing K, Yaginuma K, Theill LE, Stauber C, Karin M, Mellon PL. GHF-1 - promoter-targeted immortalization of a somatotropic progenitor cell results in dwarfism in transgenic mice Genes and Development. 7: 683-693. PMID 8096199 DOI: 10.1101/Gad.7.4.683 |
0.356 |
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| 1993 |
Devary Y, Gottlieb RA, Smeal T, Karin M. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell. 71: 1081-91. PMID 1473146 DOI: 10.1016/S0092-8674(05)80058-3 |
0.387 |
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| 1993 |
Karin M, Smeal T. Control of transcription factors by signal transduction pathways: the beginning of the end. Trends in Biochemical Sciences. 17: 418-22. PMID 1455510 DOI: 10.1016/0968-0004(92)90012-X |
0.362 |
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| 1992 |
Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature. 354: 494-6. PMID 1749429 DOI: 10.1038/354494A0 |
0.353 |
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| 1992 |
Hunter T, Karin M. The regulation of transcription by phosphorylation. Cell. 70: 375-87. PMID 1643656 DOI: 10.1016/0092-8674(92)90162-6 |
0.333 |
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| 1992 |
Smeal T, Binetruy B, Mercola D, Grover-Bardwick A, Heidecker G, Rapp UR, Karin M. Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Molecular and Cellular Biology. 12: 3507-13. PMID 1630458 DOI: 10.1128/MCB.12.8.3507 |
0.361 |
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| 1992 |
Deng T, Karin M. Construction and expression of a monomeric c-Jun protein that binds and activates transcription of AP-1-responsive genes. Proceedings of the National Academy of Sciences of the United States of America. 89: 8572-6. PMID 1528863 DOI: 10.1073/PNAS.89.18.8572 |
0.333 |
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| 1992 |
Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T, Brenner D, Karin M. Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell. 70: 777-89. PMID 1516134 DOI: 10.1016/0092-8674(92)90311-Y |
0.379 |
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| 1992 |
Mercurio F, Didonato J, Rosette C, Karin M. Molecular cloning and characterization of a novel Rel/NF-kappa B family member displaying structural and functional homology to NF-kappa B p50/p105. Dna and Cell Biology. 11: 523-37. PMID 1388725 DOI: 10.1089/dna.1992.11.523 |
0.32 |
|
| 1992 |
Hagiwara M, Alberts A, Brindle P, Meinkoth J, Feramisco J, Deng T, Karin M, Shenolikar S, Montminy M. Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell. 70: 105-13. PMID 1352481 DOI: 10.1016/0092-8674(92)90537-M |
0.387 |
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| 1992 |
Trejo J, Chambard JC, Karin M, Brown JH. Biphasic Increase in c-jun mRNA Is Required for Induction of AP-1-Mediated Gene Transcription: Differential Effects of Muscarinic and Thrombin Receptor Activation Molecular and Cellular Biology. 12: 4742-4750. PMID 1328861 DOI: 10.1128/Mcb.12.10.4742 |
0.346 |
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| 1992 |
Karin M. Signal transduction from cell surface to nucleus in development and disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 6: 2581-90. PMID 1317309 DOI: 10.1096/FASEBJ.6.8.1317309 |
0.356 |
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| 1992 |
Li L, Chambard JC, Karin M, Olson EN. Fos and Jun repress transcriptional activation by myogenin and MyoD: the amino terminus of Jun can mediate repression. Genes & Development. 6: 676-89. PMID 1313772 DOI: 10.1101/Gad.6.4.676 |
0.369 |
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| 1992 |
Theill L, Hattori K, Lazzaro D, Castrillo J, Karin M. Differential splicing of the GHF1 primary transcript gives rise to two functionally distinct homeodomain proteins. The Embo Journal. 11: 2261-2269. DOI: 10.1002/j.1460-2075.1992.tb05285.x |
0.344 |
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| 1991 |
Hattori M, Tugores A, Veloz L, Karin M, Brenner DA. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Dna and Cell Biology. 9: 777-81. PMID 2264931 DOI: 10.1089/Dna.1990.9.777 |
0.304 |
|
| 1991 |
Lafyatis R, Kim SJ, Angel P, Roberts AB, Sporn MB, Karin M, Wilder RL. Interleukin-1 stimulates and all-trans-retinoic acid inhibits collagenase gene expression through its 5' activator protein-1-binding site. Molecular Endocrinology (Baltimore, Md.). 4: 973-80. PMID 2178224 DOI: 10.1210/Mend-4-7-973 |
0.327 |
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| 1991 |
Kim SJ, Lafyatis R, Kim KY, Angel P, Fujiki H, Karin M, Sporn MB, Roberts AB. Regulation of collagenase gene expression by okadaic acid, an inhibitor of protein phosphatases. Cell Regulation. 1: 269-78. PMID 1966042 DOI: 10.1091/Mbc.1.3.269 |
0.367 |
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| 1991 |
Binétruy B, Smeal T, Karin M. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. Nature. 351: 122-7. PMID 1903181 DOI: 10.1038/351122A0 |
0.325 |
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| 1991 |
Devary Y, Gottlieb RA, Lau LF, Karin M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Molecular and Cellular Biology. 11: 2804-11. PMID 1901948 DOI: 10.1128/Mcb.11.5.2804 |
0.35 |
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| 1991 |
McCormick A, Brady H, Fukushima J, Karin M. The pituitary-specific regulatory gene GHF1 contains a minimal cell type-specific promoter centered around its TATA box. Genes & Development. 5: 1490-503. PMID 1869051 DOI: 10.1101/GAD.5.8.1490 |
0.339 |
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| 1991 |
Boyle WJ, Smeal T, Defize LHK, Angel P, Woodgett JR, Karin M, Hunter T. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity Cell. 64: 573-584. PMID 1846781 DOI: 10.1016/0092-8674(91)90241-P |
0.369 |
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| 1991 |
Karin M. Signal transduction and gene control. Current Opinion in Cell Biology. 3: 467-73. PMID 1832548 DOI: 10.1016/0955-0674(91)90075-A |
0.39 |
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| 1991 |
Castrillo JL, Theill LE, Karin M. Function of the homeodomain protein GHF1 in pituitary cell proliferation. Science (New York, N.Y.). 253: 197-9. PMID 1677216 DOI: 10.1126/SCIENCE.1677216 |
0.33 |
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| 1990 |
Theill LE, Castrillo JL, Wu D, Karin M. Dissection of functional domains of the pituitary-specific transcription factor GHF-1. Nature. 342: 945-8. PMID 2574416 DOI: 10.1038/342945A0 |
0.337 |
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| 1990 |
Chiu R, Angel P, Karin M. Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell. 59: 979-86. PMID 2513128 DOI: 10.1016/0092-8674(89)90754-X |
0.346 |
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| 1990 |
Karin M, Castrillo JL, Theill LE. Growth hormone gene regulation: a paradigm for cell-type-specific gene activation. Trends in Genetics : Tig. 6: 92-6. PMID 2183418 DOI: 10.1016/0168-9525(90)90100-K |
0.311 |
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| 1990 |
Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M. Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell. 62: 1205-15. PMID 2169352 DOI: 10.1016/0092-8674(90)90396-V |
0.374 |
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| 1990 |
Allegretto EA, Smeal T, Angel P, Spiegelman BM, Karin M. DNA-binding activity of Jun is increased through its interaction with Fos. Journal of Cellular Biochemistry. 42: 193-206. PMID 2111328 DOI: 10.1002/jcb.240420403 |
0.322 |
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| 1990 |
McCormick A, Brady H, Theill LE, Karin M. Regulation of the pituitary-specific homeobox gene GHF1 by cell-autonomous and environmental cues. Nature. 345: 829-32. PMID 1972784 DOI: 10.1038/345829A0 |
0.335 |
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| 1990 |
Dollé P, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M. Expression of GHF-1 protein in mouse pituitaries correlates both temporally and spatially with the onset of growth hormone gene activity Cell. 60: 809-820. PMID 1690079 DOI: 10.1016/0092-8674(90)90095-V |
0.3 |
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| 1989 |
Angel P, Hattori K, Smeal T, Karin M. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell. 55: 875-85. PMID 3142689 DOI: 10.1016/0092-8674(88)90143-2 |
0.373 |
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| 1989 |
Muegge K, Williams TM, Kant J, Karin M, Chiu R, Schmidt A, Siebenlist U, Young HA, Durum SK. Interleukin-1 costimulatory activity on the interleukin-2 promoter via AP-1. Science (New York, N.Y.). 246: 249-51. PMID 2799385 DOI: 10.1126/Science.2799385 |
0.317 |
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| 1989 |
Castrillo JL, Bodner M, Karin M. Purification of growth hormone-specific transcription factor GHF-1 containing homeobox. Science (New York, N.Y.). 243: 814-7. PMID 2563596 DOI: 10.1126/SCIENCE.2563596 |
0.316 |
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| 1989 |
Dana S, Karin M. Induction of human growth hormone promoter activity by the adenosine 3',5'-monophosphate pathway involves a novel responsive element. Molecular Endocrinology (Baltimore, Md.). 3: 815-21. PMID 2547155 DOI: 10.1210/MEND-3-5-815 |
0.358 |
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| 1989 |
Brenner DA, O'Hara M, Angel P, Chojkier M, Karin M. Prolonged activation of jun and collagenase genes by tumour necrosis factor-alpha. Nature. 337: 661-3. PMID 2537468 DOI: 10.1038/337661A0 |
0.313 |
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| 1989 |
Mercurio F, Karin M. Transcription factors AP-3 and AP-2 interact with the SV40 enhancer in a mutually exclusive manner. The Embo Journal. 8: 1455-1460. DOI: 10.1002/j.1460-2075.1989.tb03528.x |
0.353 |
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| 1989 |
Serfling E, Barthelmäs R, Pfeuffer I, Schenk B, Zarius S, Swoboda R, Mercurio F, Karin M. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. The Embo Journal. 8: 465-473. DOI: 10.1002/j.1460-2075.1989.tb03399.x |
0.341 |
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| 1988 |
Angel P, Allegretto EA, Okino ST, Hattori K, Boyle WJ, Hunter T, Karin M. Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature. 332: 166-71. PMID 3347253 DOI: 10.1038/332166A0 |
0.35 |
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| 1988 |
Hattori K, Angel P, Le Beau MM, Karin M. Structure and chromosomal localization of the functional intronless human JUN protooncogene. Proceedings of the National Academy of Sciences of the United States of America. 85: 9148-52. PMID 3194415 DOI: 10.1073/pnas.85.23.9148 |
0.309 |
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| 1988 |
McCormick A, Wu D, Castrillo JL, Dana S, Strobl J, Thompson EB, Karin M. Extinction of growth hormone expression in somatic cell hybrids involves repression of the specific trans-activator GHF-1. Cell. 55: 379-89. PMID 3167985 DOI: 10.1016/0092-8674(88)90061-X |
0.318 |
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| 1988 |
Chiu R, Boyle WJ, Meek J, Smeal T, Hunter T, Karin M. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell. 54: 541-52. PMID 3135940 DOI: 10.1016/0092-8674(88)90076-1 |
0.373 |
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| 1988 |
Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M, Karin M. The pituitary-specific transcription factor GHF-1 is a homeobox-containing protein. Cell. 55: 505-18. PMID 2902927 DOI: 10.1016/0092-8674(88)90037-2 |
0.321 |
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| 1988 |
Slater EP, Cato AC, Karin M, Baxter JD, Beato M. Progesterone induction of metallothionein-IIA gene expression. Molecular Endocrinology (Baltimore, Md.). 2: 485-91. PMID 2843758 DOI: 10.1210/Mend-2-6-485 |
0.519 |
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| 1987 |
Bodner M, Karin M. A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells. Cell. 50: 267-75. PMID 3594572 DOI: 10.1016/0092-8674(87)90222-4 |
0.34 |
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| 1987 |
Angel P, Imagawa M, Chiu R, Stein B, Imbra RJ, Rahmsdorf HJ, Jonat C, Herrlich P, Karin M. Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor. Cell. 49: 729-39. PMID 3034432 DOI: 10.1016/0092-8674(87)90611-8 |
0.366 |
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| 1987 |
Lee W, Haslinger A, Karin M, Tjian R. Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Nature. 325: 368-72. PMID 3027570 DOI: 10.1038/325368A0 |
0.314 |
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| 1987 |
Imagawa M, Chiu R, Karin M. Transcription factor AP-2 mediates induction by two different signal-transduction pathways: protein kinase C and cAMP. Cell. 51: 251-60. PMID 2822255 DOI: 10.1016/0092-8674(87)90152-8 |
0.412 |
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| 1987 |
Chiu R, Imagawa M, Imbra RJ, Bockoven JR, Karin M. Multiple cis- and trans-acting elements mediate the transcriptional response to phorbol esters. Nature. 329: 648-51. PMID 2821407 DOI: 10.1038/329648A0 |
0.395 |
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| 1987 |
Lefevre C, Imagawa M, Dana S, Grindlay J, Bodner M, Karin M. Tissue-specific expression of the human growth hormone gene is conferred in part by the binding of a specific trans-acting factor. The Embo Journal. 6: 971-981. DOI: 10.1002/J.1460-2075.1987.Tb04847.X |
0.329 |
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| 1986 |
Imbra RJ, Karin M. Phorbol ester induces the transcriptional stimulatory activity of the SV40 enhancer. Nature. 323: 555-8. PMID 3020435 DOI: 10.1038/323555a0 |
0.391 |
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| 1985 |
Slater EP, Rabenau O, Karin M, Baxter JD, Beato M. Glucocorticoid receptor binding and activation of a heterologous promoter by dexamethasone by the first intron of the human growth hormone gene. Molecular and Cellular Biology. 5: 2984-92. PMID 3018491 DOI: 10.1128/Mcb.5.11.2984 |
0.445 |
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| 1984 |
Karin M, Eberhardt NL, Mellon SH, Malich N, Richards RI, Slater EP, Barta A, Martial JA, Baxter JD, Cathala G. Expression and hormonal regulation of the rat growth hormone gene in transfected mouse L cells. Dna (Mary Ann Liebert, Inc.). 3: 147-55. PMID 6723496 |
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| 1984 |
Karin M, Haslinger A, Holtgreve H, Cathala G, Slater E, Baxter JD. Activation of a heterologous promoter in response to dexamethasone and cadmium by metallothionein gene 5'-flanking DNA. Cell. 36: 371-9. PMID 6692472 DOI: 10.1016/0092-8674(84)90230-7 |
0.451 |
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| 1983 |
Cathala G, Savouret JF, Mendez B, West BL, Karin M, Martial JA, Baxter JD. A method for isolation of intact, translationally active ribonucleic acid. Dna (Mary Ann Liebert, Inc.). 2: 329-35. PMID 6198133 |
0.569 |
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| 1981 |
Karin M, Andersen RD, Herschman HR. Induction of metallothionein mRNA in HeLa cells by dexamethasone and by heavy metals. European Journal of Biochemistry / Febs. 118: 527-31. PMID 7297561 DOI: 10.1111/J.1432-1033.1981.Tb05551.X |
0.482 |
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| 1981 |
Karin M, Herschman HR. Induction of metallothionein in HeLa cells by dexamethasone and zinc. European Journal of Biochemistry / Febs. 113: 267-72. PMID 7202410 DOI: 10.1111/J.1432-1033.1981.Tb05062.X |
0.425 |
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| 1981 |
Karin M, Slater EP, Herschman HR. Regulation of metallothionein synthesis in HeLa cells by heavy metals and glucocorticoids. Journal of Cellular Physiology. 106: 63-74. PMID 6162854 DOI: 10.1002/Jcp.1041060108 |
0.499 |
|
| 1980 |
Karin M, Herschman HR. Glucocorticoid hormone receptor mediated induction of metallothionein synthesis in HeLa cells. Journal of Cellular Physiology. 103: 35-40. PMID 7430258 DOI: 10.1002/Jcp.1041030106 |
0.505 |
|
| 1980 |
Karin M, Andersen RD, Slater E, Smith K, Herschman HR. Metallothionein mRNA induction in HeLa cells in response to zinc or dexamethasone is a primary induction response. Nature. 286: 295-7. PMID 7402316 DOI: 10.1038/286295A0 |
0.505 |
|
| 1980 |
Karin M, Herschman HR. Characterization of the metallothioneins induced in HeLa cells by dexamethasone and zinc. European Journal of Biochemistry / Febs. 107: 395-401. PMID 7398649 DOI: 10.1111/J.1432-1033.1980.Tb06042.X |
0.454 |
|
| 1980 |
Karin M, Herschman HR, Weinstein D. Primary induction of metallothionein by dexamethasone in culture rat hepatocytes. Biochemical and Biophysical Research Communications. 92: 1052-69. PMID 7362599 DOI: 10.1016/0006-291X(80)90808-6 |
0.468 |
|
| 1979 |
Karin M, Herschman HR. Dexamethasone stimulation of metallothionein synthesis in HeLa cell cultures. Science (New York, N.Y.). 204: 176-7. PMID 432639 DOI: 10.1126/Science.432639 |
0.479 |
|
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