| Year |
Citation |
Score |
| 2008 |
Wernig G, Kharas MG, Okabe R, Moore SA, Leeman DS, Cullen DE, Gozo M, McDowell EP, Levine RL, Doukas J, Mak CC, Noronha G, Martin M, Ko YD, Lee BH, et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell. 13: 311-20. PMID 18394554 DOI: 10.1016/J.Ccr.2008.02.009 |
0.346 |
|
| 2008 |
Palanki MS, Akiyama H, Campochiaro P, Cao J, Chow CP, Dellamary L, Doukas J, Fine R, Gritzen C, Hood JD, Hu S, Kachi S, Kang X, Klebansky B, Kousba A, ... ... Martin M, et al. Development of prodrug 4-chloro-3-(5-methyl-3-{[4-(2-pyrrolidin-1-ylethoxy)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenyl benzoate (TG100801): a topically administered therapeutic candidate in clinical trials for the treatment of age-related macular degeneration. Journal of Medicinal Chemistry. 51: 1546-59. PMID 18311895 DOI: 10.1021/Jm7011276 |
0.316 |
|
| 2008 |
Smith BM, Smith JM, Tsai JH, Schultz JA, Gilson CA, Estrada SA, Chen RR, Park DM, Prieto EB, Gallardo CS, Sengupta D, Dosa PI, Covel JA, Ren A, Webb RR, ... ... Martin M, et al. Discovery and structure-activity relationship of (1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine (Lorcaserin), a selective serotonin 5-HT2C receptor agonist for the treatment of obesity. Journal of Medicinal Chemistry. 51: 305-13. PMID 18095642 DOI: 10.1021/Jm0709034 |
0.308 |
|
| 2007 |
Kousba AA, Soll RM, Yee S, Martin MB. Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase. Drug Metabolism and Disposition. 35: 2242-2251. PMID 17881660 DOI: 10.1124/Dmd.107.017384 |
0.318 |
|
| 2007 |
Palanki MS, Dneprovskaia E, Doukas J, Fine RM, Hood J, Kang X, Lohse D, Martin M, Noronha G, Soll RM, Wrasidlo W, Yee S, Zhu H. Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction. Journal of Medicinal Chemistry. 50: 4279-94. PMID 17685602 DOI: 10.1021/Jm051056C |
0.325 |
|
| 2007 |
Wernig G, Kharas MG, Okabe R, Moore SA, Leeman DS, Cullen DE, Gozo M, McDowell EP, Levine RL, Doukas J, Mak CC, Noronha G, Martin M, Ko YD, Lee BH, et al. Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera. Blood. 110: 556-556. DOI: 10.1182/Blood.V110.11.556.556 |
0.365 |
|
| 2002 |
Rodriguez N, Bailey BN, Martin MB, Oldfield E, Urbina JA, Docampo R. Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate. The Journal of Infectious Diseases. 186: 138-40. PMID 12089677 DOI: 10.1086/341074 |
0.465 |
|
| 2002 |
Martin MB, Sanders JM, Kendrick H, de Luca-Fradley K, Lewis JC, Grimley JS, Van Brussel EM, Olsen JR, Meints GA, Burzynska A, Kafarski P, Croft SL, Oldfield E. Activity of bisphosphonates against Trypanosoma brucei rhodesiense. Journal of Medicinal Chemistry. 45: 2904-14. PMID 12086478 DOI: 10.1021/Jm0102809 |
0.636 |
|
| 2002 |
Szabo CM, Martin MB, Oldfield E. An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs. Journal of Medicinal Chemistry. 45: 2894-903. PMID 12086477 DOI: 10.1021/Jm010279+ |
0.7 |
|
| 2002 |
Szabo CM, Matsumura Y, Fukura S, Martin MB, Sanders JM, Sengupta S, Cieslak JA, Loftus TC, Lea CR, Lee HJ, Koohang A, Coates RM, Sagami H, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. Journal of Medicinal Chemistry. 45: 2185-96. PMID 12014956 DOI: 10.1021/Jm010412Y |
0.688 |
|
| 2002 |
Yardley V, Khan AA, Martin MB, Slifer TR, Araujo FG, Moreno SN, Docampo R, Croft SL, Oldfield E. In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. 46: 929-31. PMID 11850291 DOI: 10.1128/Aac.46.3.929-931.2002 |
0.465 |
|
| 2001 |
Montalvetti A, Bailey BN, Martin MB, Severin GW, Oldfield E, Docampo R. Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. The Journal of Biological Chemistry. 276: 33930-7. PMID 11435429 DOI: 10.1074/Jbc.M103950200 |
0.525 |
|
| 2001 |
Moreno B, Bailey BN, Luo S, Martin MB, Kuhlenschmidt M, Moreno SN, Docampo R, Oldfield E. (31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth. Biochemical and Biophysical Research Communications. 284: 632-7. PMID 11396947 DOI: 10.1006/Bbrc.2001.5009 |
0.674 |
|
| 2001 |
Martin MB, Grimley JS, Lewis JC, Heath HT, Bailey BN, Kendrick H, Yardley V, Caldera A, Lira R, Urbina JA, Moreno SN, Docampo R, Croft SL, Oldfield E. Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. Journal of Medicinal Chemistry. 44: 909-16. PMID 11300872 DOI: 10.1021/Jm0002578 |
0.541 |
|
| 1999 |
Martin MB, Arnold W, Heath HT, Urbina JA, Oldfield E. Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis. Biochemical and Biophysical Research Communications. 263: 754-8. PMID 10512752 DOI: 10.1006/Bbrc.1999.1404 |
0.621 |
|
| 1997 |
Stewart AO, Bhatia PA, Martin JG, Summers JB, Rodriques KE, Martin MB, Holms JH, Moore JL, Craig RA, Kolasa T, Ratajczyk JD, Mazdiyasni H, Kerdesky FA, DeNinno SL, Maki RG, et al. Structure-activity relationships of N-hydroxyurea 5-lipoxygenase inhibitors. Journal of Medicinal Chemistry. 40: 1955-68. PMID 9207936 DOI: 10.1021/Jm9700474 |
0.327 |
|
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