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Ronald A. DePinho, MD - Publications

Affiliations: 
President University of Texas MD Anderson Cancer Center, Houston, TX, United States 
Area:
molecular and biological processes governing the development of cancer, the basis for aging and degenerative diseases, and the maintenance of normal and cancer stem cells.
Website:
http://www.dfhcc.harvard.edu/membership/profile/member/107/0/
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377 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Shim HS, Iaconelli J, Shang X, Li J, Lan ZD, Jiang S, Nutsch K, Beyer BB, Lairson LL, Boutin AT, Bollong MJ, Schultz PG, DePinho RA. TERT activation targets DNA methylation and multiple aging hallmarks. Cell. PMID 38908367 DOI: 10.1016/j.cell.2024.05.048  0.704
2023 Han J, Xu J, Liu Y, Liang S, LaBella KA, Chakravarti D, Spring DJ, Xia Y, DePinho RA. Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer. Genes & Development. PMID 37775182 DOI: 10.1101/gad.351037.123  0.313
2023 Li J, Lan Z, Liao W, Horner JW, Xu X, Liu J, Yoshihama Y, Jiang S, Shim HS, Slotnik M, LaBella KA, Wu CJ, Dunner K, Hsu WH, Lee R, ... ... DePinho RA, et al. Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature. PMID 37344599 DOI: 10.1038/s41586-023-06254-7  0.313
2022 Lee R, Li J, Li J, Wu CJ, Jiang S, Hsu WH, Chakravarti D, Chen P, LaBella KA, Li J, Spring DJ, Zhao D, Wang YA, DePinho RA. Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer. Cancer Discovery. PMID 35537038 DOI: 10.1158/2159-8290.CD-21-0680  0.311
2021 Dayde D, Gunther J, Hirayama Y, Weksberg DC, Boutin A, Parhy G, Aguilar-Bonavides C, Wang H, Katayama H, Abe Y, Do KA, Hara K, Kinoshita T, Komori K, Shimizu Y, ... ... DePinho R, et al. Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer. Cancers. 13. PMID 34298853 DOI: 10.3390/cancers13143642  0.68
2020 Zhao D, Cai L, Lu X, Liang X, Li J, Chen P, Ittmann M, Shang X, Jiang S, Li H, Meng C, Flores I, Song JH, Horner JW, Lan Z, ... ... DePinho RA, et al. Chromatin Regulator, CHD1, Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer. Cancer Discovery. PMID 32385075 DOI: 10.1158/2159-8290.Cd-19-1352  0.397
2020 Huang T, Cheng X, Chahoud J, Sarhan A, Tamboli P, Rao P, Guo M, Manyam G, Zhang L, Xiang Y, Han L, Shang X, Deng P, Luo Y, Lu X, ... ... DePinho RA, et al. Effective combinatorial immunotherapy for penile squamous cell carcinoma. Nature Communications. 11: 2124. PMID 32358507 DOI: 10.1038/S41467-020-15980-9  0.341
2020 Hou P, Kapoor A, Zhang Q, Li J, Wu CJ, Li J, Lan Z, Tang M, Ma X, Ackroyd JJ, Kalluri R, Zhang J, Jiang S, Spring DJ, Wang YA, ... DePinho RA, et al. Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer. Cancer Discovery. PMID 32341020 DOI: 10.1158/2159-8290.Cd-19-0597  0.4
2020 Li X, Qian X, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, DePinho RA, Lu Z. Programmable base editing of mutated TERT promoter inhibits brain tumour growth. Nature Cell Biology. PMID 32066906 DOI: 10.1038/S41556-020-0471-6  0.404
2020 Dey P, Li J, Zhang J, Chaurasiya S, Strom A, Wang H, Liao WT, Cavallaro F, Denz P, Bernard V, Yen EY, Genovese G, Gulhati P, Liu J, Chakravarti D, ... ... DePinho RA, et al. Oncogenic Kras driven metabolic reprogramming in pancreas cancer cells utilizes cytokines from the tumor microenvironment. Cancer Discovery. PMID 32046984 DOI: 10.1158/2159-8290.Cd-19-0297  0.376
2020 Chen P, Hsu WH, Chang A, Tan Z, Lan Z, Zhou A, Spring DJ, Lang FF, Wang YA, DePinho RA. Circadian regulator CLOCK recruits immune suppressive microglia into the GBM tumor microenvironment. Cancer Discovery. PMID 31919052 DOI: 10.1158/2159-8290.Cd-19-0400  0.387
2020 Liao W, Overman MJ, Boutin A, Dey P, Zhao D, Wang G, Li J, Lan Z, Li J, Shang X, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, ... ... DePinho RA, et al. Abstract IA27: Context-dependent role of KRAS in GI malignancies Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-Ia27  0.749
2020 Wang G, Lu X, Chakravarti D, Kapoor A, Yao W, Ying H, Dey P, Wu C, Spring D, Hou P, Deng P, Zhao D, Hu B, Xizeng M, Logothesis C, ... ... DePinho RA, et al. Abstract IA24: YAP in cancer and inflammation Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-Ia24  0.371
2020 Boutin A, Chen P, Dey P, Hou P, Liao W, Lu X, Ying H, Zhao D, DePinho RA. Abstract IA01: Modeling and understanding tumor biologic mechanisms Cancer Research. 80. DOI: 10.1158/1538-7445.Camodels2020-Ia01  0.747
2019 Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, ... ... DePinho RA, et al. Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer. Cell. 179: 1239. PMID 31730860 DOI: 10.1016/J.Cell.2019.10.037  0.582
2019 Hou P, Ma X, Zhang Q, Wu CJ, Liao W, Li J, Wang H, Zhao J, Zhou X, Guan C, Ackroyd J, Jiang S, Zhang J, Spring DJ, Wang YA, ... DePinho RA, et al. USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation. Genes & Development. PMID 31488580 DOI: 10.1101/Gad.326314.119  0.446
2019 Chen P, Zhao D, Li J, Liang X, Li J, Chang A, Henry VK, Lan Z, Spring DJ, Rao G, Wang YA, DePinho RA. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 35: 868-884.e6. PMID 31185211 DOI: 10.1016/J.Ccell.2019.05.003  0.349
2019 Frenquelli M, Caridi N, Antonini E, Storti F, Viganò V, Gaviraghi M, Occhionorelli M, Bianchessi S, Bongiovanni L, Spinelli A, Marcatti M, Belloni D, Ferrero E, Karki S, Brambilla P, ... ... DePinho RA, et al. The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation. Leukemia. 34: 257-270. PMID 31148590 DOI: 10.1038/S41375-019-0486-9  0.365
2019 Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, ... ... DePinho RA, et al. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. PMID 30918400 DOI: 10.1038/S41586-019-1062-1  0.397
2019 Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, ... ... DePinho RA, et al. KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer. Cancer Cell. PMID 30905761 DOI: 10.1016/J.Ccell.2019.02.008  0.716
2019 Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, ... ... DePinho RA, et al. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Reports. 26: 469-482.e5. PMID 30625329 DOI: 10.1016/J.Celrep.2018.12.043  0.407
2019 Chen P, Wang A, DePinho R. Abstract A060: Targeting glioma-macrophage interplay via LOX in PTEN-deficient glioblastoma Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-A060  0.452
2019 Dey P, Li J, Zhang J, Wang H, Liao W, Bernard VP, Genovese G, Maitra A, Strom A, DePinho RA. Abstract A09: CD4 T cells mediated protumorigenic pathway in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A09  0.388
2019 Chen P, DePinho R, Alan W. TMIC-07. SYMBIOTIC MACROPHAGE-GLIOMA CELL INTERACTIONS REVEAL SYNTHETIC LETHALITY IN PTEN NULL GLIOMA Neuro-Oncology. 21: vi248-vi248. DOI: 10.1093/Neuonc/Noz175.1041  0.388
2018 Moreira D, Adamus T, Zhao X, Su YL, Zhang Z, White SV, Swiderski P, Lu X, DePinho RA, Pal SK, Kortylewski M. STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30337279 DOI: 10.1158/1078-0432.Ccr-18-1277  0.366
2018 Wang G, Zhao D, Spring DJ, DePinho RA. Genetics and biology of prostate cancer. Genes & Development. 32: 1105-1140. PMID 30181359 DOI: 10.1101/Gad.315739.118  0.363
2018 Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, ... ... DePinho RA, et al. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nature Medicine. PMID 29892070 DOI: 10.1038/S41591-018-0052-4  0.374
2018 Lu X, Pan X, Wu CJ, Zhao D, Feng S, Zang Y, Lee R, Khadka S, Amin SB, Jin EJ, Shang X, Deng P, Luo Y, Morgenlander WR, Weinrich J, ... ... DePinho RA, et al. An in vivo screen identifies PYGO2 as a driver for metastatic prostate cancer. Cancer Research. PMID 29769196 DOI: 10.1158/0008-5472.Can-17-3564  0.389
2018 Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, ... ... DePinho RA, et al. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 33: 152. PMID 29316430 DOI: 10.1016/J.Ccell.2017.12.012  0.343
2018 Dey P, Baddour J, Kim Y, Macloed R, Muller F, Wu CC, Wang H, Viale A, Ying H, Draetta G, Maitra A, Wang A, Nagrath D, DePinho R. Abstract 777: Malic enzyme 3 as a collateral lethality target in pancreatic cancer Cancer Research. 78: 777-777. DOI: 10.1158/1538-7445.Am2018-777  0.458
2017 Lu X, Jin EJ, Cheng X, Feng S, Shang X, Deng P, Jiang S, Chang Q, Rahmy S, Chaudhary S, Lu X, Zhao R, Wang YA, DePinho RA. Opposing roles of TGFβ and BMP signaling in prostate cancer development. Genes & Development. 31: 2337-2342. PMID 29352019 DOI: 10.1101/Gad.307116.117  0.33
2017 Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Bluestone JA, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, ... DePinho RA, et al. Future cancer research priorities in the USA: a Lancet Oncology Commission. The Lancet. Oncology. 18: e653-e706. PMID 29208398 DOI: 10.1016/S1470-2045(17)30698-8  0.321
2017 Ong DST, Hu B, Ho YW, Sauvé CG, Bristow CA, Wang Q, Multani AS, Chen P, Nezi L, Jiang S, Gorman CE, Monasterio MM, Koul D, Marchesini M, Colla S, ... ... DePinho RA, et al. PAF promotes stemness and radioresistance of glioma stem cells. Proceedings of the National Academy of Sciences of the United States of America. 114: E9086-E9095. PMID 29073105 DOI: 10.1073/Pnas.1708122114  0.597
2017 Yang Y, Blee AM, Wang D, An J, Pan Y, Yan Y, Ma T, He Y, Dugdale J, Hou X, Zhang J, Weroha SJ, Zhu WG, Wang YA, DePinho RA, et al. Loss of FOXO1 cooperates with TMPRSS2-ERG overexpression to promote prostate tumorigenesis and cell invasion. Cancer Research. PMID 28986382 DOI: 10.1158/0008-5472.Can-17-0686  0.36
2017 Sarkar S, Bristow CA, Dey P, Rai K, Perets R, Ramirez-Cardenas A, Malasi S, Huang-Hobbs E, Haemmerle M, Wu SY, McGuire M, Protopopov A, Jiang S, Liu JF, Hirsch MS, ... ... DePinho R, et al. PRKCI promotes immune suppression in ovarian cancer. Genes & Development. PMID 28698296 DOI: 10.1101/Gad.296640.117  0.645
2017 Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, ... ... DePinho RA, et al. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 32: 42-56.e6. PMID 28697342 DOI: 10.1016/J.Ccell.2017.06.003  0.37
2017 Zhao D, DePinho RA. Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 28675450 DOI: 10.1002/Bies.201700076  0.416
2017 Marchesini M, Ogoti Y, Fiorini E, Aktas Samur A, Nezi L, D'Anca M, Storti P, Samur MK, Ganan-Gomez I, Fulciniti MT, Mistry N, Jiang S, Bao N, Marchica V, Neri A, ... ... DePinho RA, et al. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. PMID 28669490 DOI: 10.1016/j.ccell.2017.05.011  0.308
2017 Lu X, Horner JW, Paul E, Shang X, Troncoso P, Deng P, Jiang S, Chang Q, Spring DJ, Sharma P, Zebala JA, Maeda DY, Wang YA, DePinho RA. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. PMID 28321130 DOI: 10.1038/Nature21676  0.327
2017 Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, ... ... DePinho RA, et al. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes & Development. PMID 28289141 DOI: 10.1101/Gad.293449.116  0.807
2017 Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J, Hung MC, ... DePinho RA, et al. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nature Communications. 8: 14437. PMID 28232723 DOI: 10.1038/Ncomms14437  0.337
2017 Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, ... ... DePinho RA, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. PMID 28178232 DOI: 10.1038/Nature21064  0.633
2017 Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, Liang X, Chen JR, Shah S, Shang X, Tang M, Deng P, Dey P, Chakravarti D, Chen P, ... ... DePinho RA, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. PMID 28166537 DOI: 10.1038/Nature21357  0.418
2017 Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, ... ... DePinho RA, et al. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. PMID 28099419 DOI: 10.1038/Nature21052  0.371
2017 Lin Y, Satani N, Hammoudi N, Pisaneschi F, Leonard P, Maxwell D, Peng Z, Link T, Gilbert LIR, Bosajou A, Sun D, Marszalek J, Sun Y, McMurray JS, Mandal PK, ... ... DePinho RA, et al. Abstract A39: Pomhex, a cell-permeable high potency enolase inhibitor with utility for collateral lethality treatment of cancer Molecular Cancer Therapeutics. 16. DOI: 10.1158/1538-8514.Synthleth-A39  0.364
2017 Wang Q, Hu B, Hu X, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel FP, Cho HJ, Lin Y, Satani N, Martinez-Ledesma E, Zheng S, ... ... Depinho R, et al. TMIC-22. DECIPHERING GLIOMA INTRINSIC TRANSCRIPTIONAL SUBTYPES IDENTIFIES TUMOR EVOLUTION ASSOCIATES WITH CHANGES IN IMMUNE-MICROENVIRONMENT Neuro-Oncology. 19: vi247-vi248. DOI: 10.1093/Neuonc/Nox168.1011  0.316
2016 Hu B, Wang Q, Wang YA, Hua S, Sauvé CG, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, ... ... DePinho RA, et al. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell. 167: 1281-1295.e18. PMID 27863244 DOI: 10.1016/J.Cell.2016.10.039  0.614
2016 Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, ... ... DePinho RA, et al. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Reports. PMID 27320920 DOI: 10.1016/J.Celrep.2016.05.063  0.632
2016 Lowy D, Singer D, DePinho R, Simon GC, Soon-Shiong P. Cancer moonshot countdown. Nature Biotechnology. 34: 596-599. PMID 27281415 DOI: 10.1038/Nbt.3616  0.319
2016 Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. Journal of Immunology (Baltimore, Md. : 1950). 196: 3514-6. PMID 27183648  0.337
2016 Ying H, Dey P, Yao W, Kimmelman AC, Draetta GF, Maitra A, DePinho RA. Genetics and biology of pancreatic ductal adenocarcinoma. Genes & Development. 30: 355-85. PMID 26883357 DOI: 10.1101/Gad.275776.115  0.413
2016 Marchesini M, Ogoti Y, Fiorini E, D'anca M, Storti P, Nezi L, Samur MK, Gañán-Gómez I, Fulciniti M, Bohannan ZS, Clise-Dwyer K, Giuliani N, Munshi NC, Orlowski RZ, Garcia-Manero G, ... DePinho RA, et al. ILF2-YB1 Protein Interaction Modulates RNA Splicing to Induce Resistance to Chemotherapy in High Risk Multiple Myeloma Blood. 128: 359-359. DOI: 10.1182/Blood.V128.22.359.359  0.374
2016 Lin Y, Satani N, Hammoudi N, Marszalek J, Sun Y, Protopopova M, Francesco MED, Czako B, Wang A, DePinho RA, Muller FL. Abstract 3837: Passenger deletion of ENO1 as a collateral lethality target in cancer Cancer Research. 76: 3837-3837. DOI: 10.1158/1538-7445.Am2016-3837  0.448
2015 Muller FL, Aquilanti EA, DePinho RA. Collateral Lethality: A new therapeutic strategy in oncology. Trends in Cancer. 1: 161-173. PMID 26870836 DOI: 10.1016/J.Trecan.2015.10.002  0.438
2015 Wang G, Lu X, Dey P, Deng P, Wu CC, Jiang S, Fang Z, Zhao K, Konaparthi R, Hua S, Zhang J, Li-Ning-Tapia EM, Kapoor A, Wu CJ, Patel NB, ... ... DePinho RA, et al. Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. Cancer Discovery. PMID 26701088 DOI: 10.1186/2051-1426-3-S2-P421  0.619
2015 Taguchi A, Rho JH, Yan Q, Zhang Y, Zhao Y, Xu H, Tripathi SC, Wang H, Brenner D, Kucherlapati M, Kucherlapati RS, Boutin A, Wang YA, DePinho RA, Feng Z, et al. MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas. Cancer Prevention Research (Philadelphia, Pa.). PMID 26342024 DOI: 10.1158/1940-6207.Capr-15-0077  0.781
2015 Muller F, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee M, Hu B, Hu J, Sahin E, Ong D, ... ... DePinho RA, et al. Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. PMID 26153864 DOI: 10.1038/Nature14609  0.542
2015 Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estecio M, Weksberg DC, ... ... DePinho RA, et al. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell. 27: 644-57. PMID 25965571 DOI: 10.1016/J.Ccell.2015.04.007  0.604
2015 Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, Seydel A, Zhao J, Abraham R, Goldberg AL, Blaauw B, DePinho RA, Sandri M. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nature Communications. 6: 6670. PMID 25858807 DOI: 10.1038/Ncomms7670  0.306
2015 Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, ... ... DePinho RA, et al. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Research. 75: 1091-101. PMID 25736685 DOI: 10.1158/0008-5472.Can-14-1854  0.362
2015 Marchesini M, Ogoti Y, Ganan-Gomez I, Wei Y, Bueso-Ramos CE, Garcia-Manero G, DePinho RA, Colla S. Telomere Dysfunction-Induced DNA Damage Drives Hematopoietic Stem Cell Fate Blood. 126: 1156-1156. DOI: 10.1182/Blood.V126.23.1156.1156  0.354
2015 Viale A, Pettazzoni P, Lyssiotis C, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Heffernan T, Kimmelman A, Wang H, Fleming J, Cantley L, ... DePinho R, et al. Abstract PR13: Pancreatic tumor stem cells resistant to inhibition of oncogenic signaling are dependent on mitochondrial function Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-Pr13  0.423
2015 Kapoor A, Yao W, Ying H, Hua S, Liewen A, Sadanandam A, Al-Khalil R, Viale A, Pettazzoni P, Sanchez N, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, ... ... DePinho RA, et al. Abstract A94: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A94  0.441
2015 Yao W, Wang W, Taguchi A, Kapoor A, Momin A, Jiang H, Rose J, Celiktas M, Deem A, Hanash S, DePinho R, Ying H, Draetta G. Abstract A18: Syndecan-1 is required for oncogenic Kras-driven PDAC tumorigenesis and maintenance Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A18  0.431
2015 Lin Y, Marszalek J, Sun Y, Hammoudi N, Leonard P, Maxwell D, Satani N, Zhang P, Link T, Lee G, Francesco MED, Czako B, Want AY, DePinho RA, Muller FL. Abstract C183: Pomhex: a cell-permeable high potency Enolase inhibitor with in vivo anti-neoplastic activity Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C183  0.41
2014 Lee JH, Anver M, Kost-Alimova M, Protopopov A, DePinho RA, Rane SG. Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes & Cancer. 5: 306-19. PMID 25352948 DOI: 10.18632/Genesandcancer.31  0.324
2014 Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, ... ... DePinho RA, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 514: 628-32. PMID 25119024 DOI: 10.1038/Nature13611  0.387
2014 Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, ... ... DePinho RA, et al. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes & Development. 28: 1429-44. PMID 24990963 DOI: 10.1101/Gad.242131.114  0.31
2014 Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, ... ... DePinho RA, et al. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell. 158: 185-97. PMID 24954535 DOI: 10.1016/J.Cell.2014.06.003  0.647
2014 Stopczynski RE, Normolle DP, Hartman DJ, Ying H, DeBerry JJ, Bielefeldt K, Rhim AD, DePinho RA, Albers KM, Davis BM. Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Research. 74: 1718-27. PMID 24448244 DOI: 10.1158/0008-5472.Can-13-2050  0.329
2014 Colla S, Ong D, Ogoti Y, Marchesini M, Mistry N, Clise-Dwyer K, Storti P, Viale A, Wei Y, Giuliani N, Yang H, D'Anca M, Estecio MR, Liang H, Kantarjian HM, ... ... DePinho R, et al. A Mouse Model of Telomere Dysfunction Recapitulates Hallmark Features of Human Myelodysplastic Syndrome Blood. 124: 523-523. DOI: 10.1182/Blood.V124.21.523.523  0.401
2014 Taguchi A, Kapoor A, Momin A, Katayama H, Yao W, Wang H, Ying H, DePinho R, Hanash S. Abstract PR03: Global quantitative proteomic and phosphoproteomic analysis of oncogenic Kras-driven mouse pancreatic cancer Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-Pr03  0.382
2014 Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu C, Sadanandam A, Hu B, Chang Q, Chu G, Al-Khalil R, Jiang S, Xia H, ... ... DePinho R, et al. Abstract PR01: Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-Pr01  0.447
2014 Taguchi A, Kapoor A, Momin A, Katayama H, Yao W, Wang H, Ying H, DePinho R, Hanash S. Tu1678 Global Quantitative Proteomic and Phosphoproteomic Analysis of Oncogenic Kras-Driven Mouse Pancreatic Cancer Gastroenterology. 146: S-816. DOI: 10.1016/S0016-5085(14)62954-1  0.338
2013 Jun S, Lee S, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI. PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Reports. 5: 314-22. PMID 24209743 DOI: 10.1016/J.Celrep.2013.09.026  0.376
2013 Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155: 397-409. PMID 24120138 DOI: 10.1016/J.Cell.2013.09.025  0.411
2013 Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 14520-7. PMID 23918370 DOI: 10.1073/Pnas.1308610110  0.632
2013 Tao R, Xiong X, DePinho RA, Deng CX, Dong XC. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. Journal of Lipid Research. 54: 2745-53. PMID 23881913 DOI: 10.1194/Jlr.M039339  0.308
2013 Zhang Y, Shin SJ, Liu D, Ivanova E, Foerster F, Ying H, Zheng H, Xiao Y, Chen Z, Protopopov A, Depinho RA, Paik JH. ZNF365 promotes stability of fragile sites and telomeres. Cancer Discovery. 3: 798-811. PMID 23776040 DOI: 10.1158/2159-8290.Cd-12-0536  0.412
2013 Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Guo EX, Mann JJ, Karsenty G. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metabolism. 17: 901-15. PMID 23684624 DOI: 10.1016/J.Cmet.2013.04.009  0.476
2013 Keniry M, Pires MM, Mense S, Lefebvre C, Gan B, Justiano K, Lau YK, Hopkins B, Hodakoski C, Koujak S, Toole J, Fenton F, Calahan A, Califano A, DePinho RA, et al. Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes & Development. 27: 916-27. PMID 23630076 DOI: 10.1101/Gad.214049.113  0.406
2013 Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, ... DePinho RA, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496: 101-5. PMID 23535601 DOI: 10.1038/Nature12040  0.355
2013 Rosborough BR, Raïch-Regué D, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, Thomson AW. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood. 121: 3619-30. PMID 23444404 DOI: 10.1182/Blood-2012-08-448290  0.306
2013 Kopycinska J, KempiÅ„ska-Podhorodecka A, Haas T, Elias E, DePinho RA, Paik J, Milkiewicz P, Milkiewicz M. Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis. Liver International : Official Journal of the International Association For the Study of the Liver. 33: 231-8. PMID 23295054 DOI: 10.1111/Liv.12030  0.306
2013 Gallagher SJ, Kofman AE, Huszar JM, Dannenberg JH, DePinho RA, Braun RE, Payne CJ. Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Developmental Biology. 373: 83-94. PMID 23085237 DOI: 10.1016/J.Ydbio.2012.10.009  0.387
2013 Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, ... DePinho RA, et al. Erratum: Corrigendum: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway Nature. 499: 504-504. DOI: 10.1038/Nature12317  0.319
2012 Xiong X, Tao R, DePinho RA, Dong XC. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. The Journal of Biological Chemistry. 287: 39107-14. PMID 22992773 DOI: 10.1074/Jbc.M112.412569  0.327
2012 Shi X, Wallis AM, Gerard RD, Voelker KA, Grange RW, DePinho RA, Garry MG, Garry DJ. Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2. Journal of Cell Science. 125: 5329-37. PMID 22956541 DOI: 10.1242/Jcs.105239  0.306
2012 Lu X, Agasti SS, Vinegoni C, Waterman P, DePinho RA, Weissleder R. Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjugate Chemistry. 23: 1945-51. PMID 22917215 DOI: 10.1021/Bc300319C  0.361
2012 Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, ... ... DePinho RA, et al. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 488: 337-42. PMID 22895339 DOI: 10.1038/Nature11331  0.643
2012 Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, et al. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proceedings of the National Academy of Sciences of the United States of America. 109: 14164-9. PMID 22891331 DOI: 10.1073/Pnas.1211962109  0.323
2012 Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, ... ... Depinho RA, et al. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes & Development. 26: 1459-72. PMID 22751500 DOI: 10.1101/Gad.189001.112  0.61
2012 Kim KW, Donato J, Berglund ED, Choi YH, Kohno D, Elias CF, Depinho RA, Elmquist JK. FOXO1 in the ventromedial hypothalamus regulates energy balance. The Journal of Clinical Investigation. 122: 2578-89. PMID 22653058 DOI: 10.1172/Jci62848  0.303
2012 Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, ... ... DePinho RA, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 149: 656-70. PMID 22541435 DOI: 10.1016/J.Cell.2012.01.058  0.603
2012 Moslehi J, DePinho RA, Sahin E. Telomeres and mitochondria in the aging heart. Circulation Research. 110: 1226-37. PMID 22539756 DOI: 10.1161/Circresaha.111.246868  0.308
2012 Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, et al. Emerging insights into the molecular and cellular basis of glioblastoma. Genes & Development. 26: 756-84. PMID 22508724 DOI: 10.1101/Gad.187922.112  0.575
2012 Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, ... ... DePinho RA, et al. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 148: 896-907. PMID 22341455 DOI: 10.1016/J.Cell.2012.01.039  0.641
2012 Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, ... ... DePinho RA, et al. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 148: 651-63. PMID 22341440 DOI: 10.1016/J.Cell.2011.12.028  0.809
2012 Poché RA, Sharma R, Garcia MD, Wada AM, Nolte MJ, Udan RS, Paik JH, DePinho RA, Bartlett JD, Dickinson ME. Transcription factor FoxO1 is essential for enamel biomineralization. Plos One. 7: e30357. PMID 22291941 DOI: 10.1371/Journal.Pone.0030357  0.383
2012 Kode A, Manavalan S, Mossialou I, Bhagat G, Vundavalli M, DePinho R, Teruya-Feldstein J, Berman E, Kousteni S. Leukemogenic Transformation of Hematopoietic Cells by Constitutive Activation of Canonical Wnt Signaling in Osteoblast Precursors Blood. 120: 509-509. DOI: 10.1182/Blood.V120.21.509.509  0.344
2012 Stopczynski RE, Albers KM, Bielefeldt K, DePinho RA, Ying H, Davis BM. Abstract PR4: Neuroplastic changes and pain-related behavior in a transgenic mouse model of pancreatic ductal adenocarcinoma (PDAC). Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-Pr4  0.336
2012 DePinho RA. Abstract IA16: Kras-directed anabolic processes in PDAC tumor maintenance. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-Ia16  0.409
2012 Lyssiotis C, Ying H, Kimmelman A, DePinho R, Cantley L. Abstract A51: Oncogenic Kras is required for pancreatic tumor maintenance through the regulation of anabolic glucose metabolism. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A51  0.377
2012 Ying H, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik J, Lim C, Guimaraes AR, Kimmelman AC, Martin ES, Chang J, Hezel A, ... ... DePinho RA, et al. Abstract A101: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A101  0.373
2012 Hu J, Hwang S, Boutin A, Wang A, Chin L, Liesa M, Shiriha O, DePinho R. Abstract A37: Anti-telomerase therapy provokes ALT and mitochondrial adaptive mechanism in cancer Clinical Cancer Research. 18: A37-A37. DOI: 10.1158/1078-0432.Mechres-A37  0.751
2011 Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, ... ... DePinho RA, et al. PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. Cancer Discovery. 1: 158-69. PMID 21984975 DOI: 10.1158/2159-8290.Cd-11-0031  0.631
2011 Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, ... Depinho RA, et al. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 20: 289-99. PMID 21907921 DOI: 10.1016/J.Ccr.2011.08.007  0.32
2011 Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, ... ... Depinho RA, et al. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nature Genetics. 43: 964-8. PMID 21892161 DOI: 10.1038/Ng.936  0.803
2011 Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Schöll C, Tothova Z, Attar EC, ... ... DePinho RA, et al. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 146: 697-708. PMID 21884932 DOI: 10.1016/J.Cell.2011.07.032  0.386
2011 Draetta GF, Depinho RA. Cancer drug discovery faces the FACT. Science Translational Medicine. 3: 95ps34. PMID 21832237 DOI: 10.1126/Scitranslmed.3002822  0.359
2011 Scott KL, Nogueira C, Heffernan TP, van Doorn R, Dhakal S, Hanna JA, Min C, Jaskelioff M, Xiao Y, Wu CJ, Cameron LA, Perry SR, Zeid R, Feinberg T, Kim M, ... ... DePinho RA, et al. Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Cancer Cell. 20: 92-103. PMID 21741599 DOI: 10.1016/J.Ccr.2011.05.025  0.628
2011 Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Lopez CK, Rivera-Muñoz P, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T. Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood. 118: 1264-73. PMID 21653327 DOI: 10.1182/Blood-2011-01-328567  0.326
2011 Tao R, Wei D, Gao H, Liu Y, DePinho RA, Dong XC. Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. The Journal of Biological Chemistry. 286: 14681-90. PMID 21388966 DOI: 10.1074/Jbc.M110.201061  0.313
2011 Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, ... ... DePinho RA, et al. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 471: 104-9. PMID 21368833 DOI: 10.1038/Nature09732  0.397
2011 Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, ... ... DePinho RA, et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 470: 359-65. PMID 21307849 DOI: 10.1038/Nature09787  0.591
2011 Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, ... ... DePinho RA, et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 470: 269-73. PMID 21289624 DOI: 10.1038/Nature09677  0.593
2011 Stegh AH, DePinho RA. Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle (Georgetown, Tex.). 10: 33-8. PMID 21200141 DOI: 10.4161/Cc.10.1.14365  0.394
2011 Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. The Journal of Biological Chemistry. 286: 7468-78. PMID 21159781 DOI: 10.1074/Jbc.M110.179242  0.317
2011 Jia W, Wang S, Horner JW, Wang N, Wang H, Gunther EJ, DePinho RA, Zhu J. A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 979-89. PMID 21135040 DOI: 10.1096/Fj.10-173989  0.395
2011 Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 469: 102-6. PMID 21113150 DOI: 10.1038/Nature09603  0.359
2011 Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, Fröhling S, ... Depinho RA, et al. Erratum: AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias (Cell (2011) 146 (697-708)) Cell. 147. DOI: 10.1016/J.Cell.2011.09.015  0.305
2010 Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature. 468: 701-4. PMID 21124456 DOI: 10.1038/Nature09595  0.595
2010 Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circulation Research. 107: 1470-82. PMID 20947830 DOI: 10.1161/Circresaha.110.227371  0.317
2010 Stegh AH, Brennan C, Mahoney JA, Forloney KL, Jenq HT, Luciano JP, Protopopov A, Chin L, Depinho RA. Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes & Development. 24: 2194-204. PMID 20837658 DOI: 10.1101/Gad.1924710  0.618
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, ... ... DePinho RA, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/Nbt0910-904  0.621
2010 Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, Depinho RA, Cavenee W, Furnari F. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes & Development. 24: 1731-45. PMID 20713517 DOI: 10.1101/Gad.1890510  0.407
2010 Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NE. Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 29: 5809-17. PMID 20697345 DOI: 10.1038/Onc.2010.314  0.319
2010 Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE. Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells (Dayton, Ohio). 28: 1424-34. PMID 20572009 DOI: 10.1002/Stem.464  0.359
2010 Wilting RH, Yanover E, Heideman MR, Jacobs H, Horner J, van der Torre J, DePinho RA, Dannenberg JH. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. The Embo Journal. 29: 2586-97. PMID 20571512 DOI: 10.1038/Emboj.2010.136  0.319
2010 Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MM, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, et al. Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. Plos One. 5: e10767. PMID 20532243 DOI: 10.1371/Journal.Pone.0010767  0.593
2010 Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, ... ... DePinho RA, et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 17: 497-509. PMID 20478531 DOI: 10.1016/J.Ccr.2010.03.020  0.605
2010 Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nature Immunology. 11: 618-27. PMID 20467422 DOI: 10.1038/Ni.1884  0.319
2010 Harada Y, Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC. Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. The Journal of Experimental Medicine. 207: 1381-91. PMID 20439537 DOI: 10.1084/Jem.20100004  0.317
2010 Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bernabé RR, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, ... ... DePinho RA, ... ... DePinho RA, et al. International network of cancer genome projects. Nature. 464: 993-8. PMID 20393554 DOI: 10.1038/Nature08987  0.59
2010 Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, Huang J, Dhakal S, Ivanova E, Xiao Y, Zhang H, Hu J, Stommel JM, Lee MA, Chen AJ, ... ... DePinho RA, et al. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 6912-7. PMID 20351267 DOI: 10.1073/Pnas.0914930107  0.596
2010 Sahin E, Depinho RA. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 464: 520-8. PMID 20336134 DOI: 10.1038/Nature08982  0.345
2010 Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, DePinho RA, Kim JK, Karsenty G, Kousteni S. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. The Journal of Clinical Investigation. 120: 357-68. PMID 20038793 DOI: 10.1172/Jci39901  0.306
2010 Zhou Y, Rideout WM, Zi T, Bressel A, Reddypalli S, Rancourt R, Woo JK, Horner JW, Chin L, Chiu MI, Bosenberg M, Jacks T, Clark SC, Depinho RA, Robinson MO, et al. Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. Nature Biotechnology. 28: 71-8. PMID 20023657 DOI: 10.1038/Nbt.1595  0.623
2010 Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis. 31: 9-18. PMID 19887512 DOI: 10.1093/Carcin/Bgp268  0.683
2010 Stopczynski RE, DePinho RA, Ying H, Schwartz ES, Albers KM, Davis BM, Bielefeldt K. 412 Neuroplastic Changes in a Mouse Model of Pancreatic Ductal Adenocarcinoma (PDAC) Gastroenterology. 138: S-62. DOI: 10.1016/S0016-5085(10)60280-6  0.367
2009 Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, ... ... DePinho RA, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 5: 540-53. PMID 19896444 DOI: 10.1016/J.Stem.2009.09.013  0.594
2009 Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K. PI3 kinase signals BCR-dependent mature B cell survival. Cell. 139: 573-86. PMID 19879843 DOI: 10.1016/J.Cell.2009.08.041  0.307
2009 Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T. Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell. 16: 379-89. PMID 19878870 DOI: 10.1016/J.Ccr.2009.09.027  0.357
2009 Zhou W, Cao Q, Peng Y, Zhang QJ, Castrillon DH, DePinho RA, Liu ZP. FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation. Gastroenterology. 137: 1403-14. PMID 19560465 DOI: 10.1053/J.Gastro.2009.06.049  0.342
2009 Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, Accili D. Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Molecular and Cellular Biology. 29: 4417-30. PMID 19506018 DOI: 10.1128/Mcb.01622-08  0.333
2009 Wu M, Jung L, Cooper AB, Fleet C, Chen L, Breault L, Clark K, Cai Z, Vincent S, Bottega S, Shen Q, Richardson A, Bosenburg M, Naber SP, DePinho RA, et al. Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 7022-7. PMID 19369208 DOI: 10.1073/Pnas.0811785106  0.355
2009 Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nature Immunology. 10: 504-13. PMID 19363483 DOI: 10.1038/Ni.1729  0.335
2009 van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, ... ... DePinho RA, et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nature Genetics. 41: 521-3. PMID 19330029 DOI: 10.1038/Ng.349  0.351
2009 Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, Bosenberg M. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nature Genetics. 41: 544-52. PMID 19282848 DOI: 10.1038/Ng.356  0.355
2009 Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle (Georgetown, Tex.). 8: 1003-6. PMID 19270523 DOI: 10.4161/Cc.8.7.8045  0.362
2009 Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunology. 10: 176-84. PMID 19136962 DOI: 10.1038/Ni.1689  0.321
2009 Menon R, Zhang Q, Zhang Y, Fermin D, Bardeesy N, DePinho RA, Lu C, Hanash SM, Omenn GS, States DJ. Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer. Cancer Research. 69: 300-9. PMID 19118015 DOI: 10.1158/0008-5472.Can-08-2145  0.387
2009 Cornejo MG, Sykes SM, Celso CL, Tothova Z, Aster J, DePinho RA, Scadden DT, Gilliland DG, Mercher T. A Regulatory Network Between Notch and AKT Signaling Pathways Differentially Controls Megakaryocyte Development From Hematopoietic Stem or Committed Progenitor Cells. Blood. 114: 384-384. DOI: 10.1182/Blood.V114.22.384.384  0.366
2008 Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, ... ... dePinho RA, et al. Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harbor Symposia On Quantitative Biology. 73: 427-37. PMID 19150964 DOI: 10.1101/Sqb.2008.73.047  0.424
2008 Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proceedings of the National Academy of Sciences of the United States of America. 105: 19384-9. PMID 19052232 DOI: 10.1073/Pnas.0810584105  0.607
2008 Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, ... ... DePinho RA, et al. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proceedings of the National Academy of Sciences of the United States of America. 105: 19372-7. PMID 19050074 DOI: 10.1073/Pnas.0809966105  0.626
2008 Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, DePinho RA, Rickert RC. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nature Immunology. 9: 1388-98. PMID 18978794 DOI: 10.1038/Ni.1667  0.323
2008 Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, ... ... DePinho RA, et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 455: 1129-33. PMID 18948956 DOI: 10.1038/Nature07443  0.619
2008 Hu P, Geles KG, Paik JH, DePinho RA, Tjian R. Codependent activators direct myoblast-specific MyoD transcription. Developmental Cell. 15: 534-46. PMID 18854138 DOI: 10.1016/J.Devcel.2008.08.018  0.349
2008 Stegh AH, Chin L, Louis DN, DePinho RA. What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. Cell Cycle (Georgetown, Tex.). 7: 2833-9. PMID 18769159 DOI: 10.4161/Cc.7.18.6759  0.601
2008 Jeon HM, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes & Development. 22: 2028-33. PMID 18676808 DOI: 10.1101/Gad.1668708  0.611
2008 Stegh AH, Kesari S, Mahoney JE, Jenq HT, Forloney KL, Protopopov A, Louis DN, Chin L, DePinho RA. Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proceedings of the National Academy of Sciences of the United States of America. 105: 10703-8. PMID 18669646 DOI: 10.1073/Pnas.0712034105  0.589
2008 Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, ... ... DePinho RA, et al. A mouse to human search for plasma proteome changes associated with pancreatic tumor development. Plos Medicine. 5: e123. PMID 18547137 DOI: 10.1371/Journal.Pmed.0050123  0.389
2008 Herzog S, Hug E, Meixlsperger S, Paik JH, DePinho RA, Reth M, Jumaa H. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nature Immunology. 9: 623-31. PMID 18488031 DOI: 10.1038/Ni.1616  0.312
2008 David G, Grandinetti KB, Finnerty PM, Simpson N, Chu GC, Depinho RA. Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation. Proceedings of the National Academy of Sciences of the United States of America. 105: 4168-72. PMID 18332431 DOI: 10.1073/Pnas.0710285105  0.394
2008 Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, Feil R, DePinho RA, Mäkelä TP. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nature Genetics. 40: 455-9. PMID 18311138 DOI: 10.1038/Ng.98  0.391
2008 Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK. Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis. 29: 747-53. PMID 18283039 DOI: 10.1093/Carcin/Bgn050  0.62
2008 de la Iglesia N, Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes & Development. 22: 449-62. PMID 18258752 DOI: 10.1101/Gad.1606508  0.393
2008 Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Molecular and Cellular Biology. 28: 2414-25. PMID 18227155 DOI: 10.1128/Mcb.01621-07  0.389
2008 Tothova Z, Sykes SM, Leeman DS, Horner JW, Sharpless N, DePinho RA, Gilliland DG. p16INK4a Is a Key Downstream Mediator of the Deleterious Effects of FoxO Deficiency on Maintenance of the Hematopoietic Stem Cell Compartment. Blood. 112: 1405-1405. DOI: 10.1182/Blood.V112.11.1405.1405  0.327
2008 Mahoney JE, Sahin E, Jaskelioff M, Chin L, DePinho RA, Protopopov AI. Quantification of telomere length by FISH and laser scanning cytometry Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6859. DOI: 10.1117/12.763858  0.337
2007 O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, ... DePinho RA, et al. Alu elements mediate MYB gene tandem duplication in human T-ALL. The Journal of Experimental Medicine. 204: 3059-66. PMID 18070937 DOI: 10.1084/Jem.20071637  0.572
2007 Kim TK, Lee JS, Oh SY, Jin X, Choi YJ, Lee TH, Lee Eh, Choi YK, You S, Chung YG, Lee JB, DePinho RA, Chin L, Kim H. Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. Cancer Research. 67: 11133-40. PMID 18056437 DOI: 10.1158/0008-5472.Can-07-1342  0.635
2007 Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, DePinho RA. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Research. 67: 10736-43. PMID 18006816 DOI: 10.1158/0008-5472.Can-07-2742  0.636
2007 Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes & Development. 21: 2683-710. PMID 17974913 DOI: 10.1101/Gad.1596707  0.603
2007 Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (New York, N.Y.). 318: 287-90. PMID 17872411 DOI: 10.1126/Science.1142946  0.595
2007 Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. The Journal of Clinical Investigation. 117: 2477-85. PMID 17717603 DOI: 10.1172/Jci32054  0.318
2007 Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nature Reviews. Molecular Cell Biology. 8: 703-13. PMID 17717515 DOI: 10.1038/Nrm2241  0.334
2007 Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proceedings of the National Academy of Sciences of the United States of America. 104: 10968-73. PMID 17576930 DOI: 10.1073/Pnas.0611638104  0.383
2007 Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, ... ... DePinho RA, et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 447: 966-71. PMID 17515920 DOI: 10.1038/Nature05886  0.631
2007 Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS, Munshi N, Horner J, Ivanova EV, Protopopov A, Anderson KC, ... ... DePinho RA, et al. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell. 11: 349-60. PMID 17418411 DOI: 10.1016/J.Ccr.2007.02.015  0.327
2007 Khoo CM, Carrasco DR, Bosenberg MW, Paik JH, Depinho RA. Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proceedings of the National Academy of Sciences of the United States of America. 104: 3931-6. PMID 17360455 DOI: 10.1073/Pnas.0700093104  0.432
2007 Podar K, Raab MS, Tonon G, Sattler M, Barilà D, Zhang J, Tai YT, Yasui H, Raje N, DePinho RA, Hideshima T, Chauhan D, Anderson KC. Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. Cancer Research. 67: 1680-8. PMID 17308109 DOI: 10.1158/0008-5472.Can-06-1863  0.307
2007 Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 53: 503-17. PMID 17296553 DOI: 10.1016/J.Neuron.2007.01.009  0.373
2007 Chu GC, Kimmelman AC, Hezel AF, DePinho RA. Stromal biology of pancreatic cancer. Journal of Cellular Biochemistry. 101: 887-907. PMID 17266048 DOI: 10.1002/Jcb.21209  0.394
2007 Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, Passegué E, DePinho RA, Gilliland DG. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 128: 325-39. PMID 17254970 DOI: 10.1016/J.Cell.2007.01.003  0.342
2007 Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, ... DePinho RA, et al. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 128: 309-23. PMID 17254969 DOI: 10.1016/J.Cell.2006.12.029  0.652
2007 Sharpless NE, DePinho RA. Cancer biology: gone but not forgotten. Nature. 445: 606-7. PMID 17251931 DOI: 10.1038/Nature05567  0.377
2007 Li H, Liang J, Castrillon DH, DePinho RA, Olson EN, Liu ZP. FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription. Molecular and Cellular Biology. 27: 2676-86. PMID 17242183 DOI: 10.1128/Mcb.01748-06  0.303
2007 Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes & Development. 21: 98-111. PMID 17210792 DOI: 10.1101/Gad.1480007  0.603
2007 Maser RS, Wong KK, Sahin E, Xia H, Naylor M, Hedberg HM, Artandi SE, DePinho RA. DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Molecular and Cellular Biology. 27: 2253-65. PMID 17145779 DOI: 10.1128/Mcb.01354-06  0.621
2007 Wong KK, Maser RS, Sahin E, Bailey ST, Xia H, Ji H, McNamara K, Naylor M, Bronson RT, Ghosh S, Welsh R, DePinho RA. Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres. Oncogene. 26: 2815-21. PMID 17072335 DOI: 10.1038/Sj.Onc.1210099  0.31
2006 Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes & Development. 20: 3130-46. PMID 17114584 DOI: 10.1101/Gad.1478706  0.385
2006 Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Research. 66: 11502-13. PMID 17114236 DOI: 10.1158/0008-5472.Can-06-2072  0.591
2006 Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, et al. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Research. 66: 10815-23. PMID 17090523 DOI: 10.1158/0008-5472.Can-06-1408  0.626
2006 Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 443: 421-6. PMID 16957735 DOI: 10.1038/Nature05159  0.318
2006 Sharpless NE, Depinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nature Reviews. Drug Discovery. 5: 741-54. PMID 16915232 DOI: 10.1038/Nrd2110  0.326
2006 Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB. PCAF modulates PTEN activity. The Journal of Biological Chemistry. 281: 26562-8. PMID 16829519 DOI: 10.1074/Jbc.M605391200  0.403
2006 Farazi PA, Zeisberg M, Glickman J, Zhang Y, Kalluri R, DePinho RA. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Research. 66: 6622-7. PMID 16818635 DOI: 10.1158/0008-5472.Can-05-4609  0.32
2006 David G, Dannenberg JH, Simpson N, Finnerty PM, Miao L, Turner GM, Ding Z, Carrasco R, Depinho RA. Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53. Oncogene. 25: 7354-60. PMID 16767157 DOI: 10.1038/Sj.Onc.1209734  0.444
2006 Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, ... Depinho RA, et al. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell. 9: 379-90. PMID 16697958 DOI: 10.1016/J.Ccr.2006.03.028  0.376
2006 Bosenberg M, Muthusamy V, Curley DP, Wang Z, Hobbs C, Nelson B, Nogueira C, Horner JW, Depinho R, Chin L. Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis (New York, N.Y. : 2000). 44: 262-7. PMID 16676322 DOI: 10.1002/Dvg.20205  0.6
2006 Farazi PA, Glickman J, Horner J, Depinho RA. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Research. 66: 4766-73. PMID 16651430 DOI: 10.1158/0008-5472.Can-05-4608  0.343
2006 Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Research. 66: 4368-77. PMID 16618762 DOI: 10.1158/0008-5472.Can-05-3617  0.353
2006 Carrasco DR, Tonon G, Huang Y, Zhang Y, Sinha R, Feng B, Stewart JP, Zhan F, Khatry D, Protopopova M, Protopopov A, Sukhdeo K, Hanamura I, Stephens O, Barlogie B, ... ... Depinho RA, et al. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell. 9: 313-25. PMID 16616336 DOI: 10.1016/J.Ccr.2006.03.019  0.578
2006 Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 103: 5947-52. PMID 16585505 DOI: 10.1073/Pnas.0601273103  0.577
2006 Haines BB, Ryu CJ, Chang S, Protopopov A, Luch A, Kang YH, Draganov DD, Fragoso MF, Paik SG, Hong HJ, DePinho RA, Chen J. Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell. 9: 109-20. PMID 16473278 DOI: 10.1016/J.Ccr.2006.01.004  0.528
2006 Safran M, Kim WY, O'Connell F, Flippin L, Günzler V, Horner JW, Depinho RA, Kaelin WG. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proceedings of the National Academy of Sciences of the United States of America. 103: 105-10. PMID 16373502 DOI: 10.1073/Pnas.0509459103  0.312
2006 Podar K, Raab MS, Tonon G, Sattler M, Barila D, Tai Y, Yasui H, Raje N, Depinho RA, Hideshima T, Chauhan D, Anderson KC. Upregulation of c-Jun Induces Cell Death Via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma. Blood. 108: 3415-3415. DOI: 10.1182/Blood.V108.11.3415.3415  0.345
2006 O’Neil J, Tchinda J, Gutierrez A, Moreau L, McKenna K, Maser R, Wong K, Wu W, DePinho R, Chin L, Lee C, Look AT. Large Scale Copy Number Variation Upregulates the Expression of MYB in Human T-ALL. Blood. 108: 1408-1408. DOI: 10.1182/Blood.V108.11.1408.1408  0.379
2006 Wong K, Chang S, Depinho RA. 5 Modeling Cancer and Aging in the Telomerase-deficient Mouse Cold Spring Harbor Monograph Archive. 45: 109-138. DOI: 10.1101/087969810.45.109  0.531
2006 Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, DePinho RA. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans (DOI:10.1016/j.ccr.2006.03.028) Cancer Cell. 10: 171. DOI: 10.1016/J.Ccr.2006.07.012  0.346
2005 Tonon G, Brennan C, Protopopov A, Maulik G, Feng B, Zhang Y, Khatry DB, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Wong KK, Depinho RA. Common and contrasting genomic profiles among the major human lung cancer subtypes. Cold Spring Harbor Symposia On Quantitative Biology. 70: 11-24. PMID 16869734 DOI: 10.1101/Sqb.2005.70.021  0.417
2005 Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (New York, N.Y.). 310: 1642-6. PMID 16308421 DOI: 10.1126/Science.1120781  0.322
2005 Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S. Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes & Development. 19: 2560-70. PMID 16264192 DOI: 10.1101/Gad.1321305  0.568
2005 Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 8: 185-95. PMID 16169464 DOI: 10.1016/J.Ccr.2005.07.015  0.356
2005 Potente M, Urbich C, Sasaki K, Hofmann WK, Heeschen C, Aicher A, Kollipara R, DePinho RA, Zeiher AM, Dimmeler S. Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. The Journal of Clinical Investigation. 115: 2382-92. PMID 16100571 DOI: 10.1172/Jci23126  0.345
2005 Sharpless NE, DePinho RA. Cancer: crime and punishment. Nature. 436: 636-7. PMID 16079829 DOI: 10.1038/436636A  0.367
2005 Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10238-43. PMID 16006513 DOI: 10.1073/Pnas.0504378102  0.389
2005 Dannenberg JH, David G, Zhong S, van der Torre J, Wong WH, Depinho RA. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes & Development. 19: 1581-95. PMID 15998811 DOI: 10.1101/Gad.1286905  0.393
2005 Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA. High-resolution genomic profiles of human lung cancer. Proceedings of the National Academy of Sciences of the United States of America. 102: 9625-30. PMID 15983384 DOI: 10.1073/Pnas.0504126102  0.626
2005 Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 121: 837-48. PMID 15960972 DOI: 10.1016/J.Cell.2005.03.033  0.663
2005 Rünger TM, Vergilis I, Sarkar P, DePinho RA, Sharpless NE. How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer. Cell Cycle (Georgetown, Tex.). 4: 643-5. PMID 15846097 DOI: 10.4161/Cc.4.5.1673  0.402
2005 Okumura K, Zhao M, DePinho RA, Furnari FB, Cavenee WK. PTEN: a novel anti-oncogenic function independent of phosphatase activity. Cell Cycle (Georgetown, Tex.). 4: 540-2. PMID 15753657 DOI: 10.4161/Cc.4.4.1614  0.377
2005 Okumura K, Zhao M, Depinho RA, Furnari FB, Cavenee WK. Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 102: 2703-6. PMID 15659546 DOI: 10.1073/Pnas.0409370102  0.337
2005 Carrasco RD, Sukhdeo K, Protopopova M, German M, Henderson J, Anderson KC, DePinho RA. Targeted Overexpression of the Transcription Factor XBP-1 in B Cells Promotes Plasma Cell and Lymphoplasmacytic Neoplasms in Transgenic Mice. Blood. 106: 359-359. DOI: 10.1182/Blood.V106.11.359.359  0.399
2005 Tothova Z, Kollipara R, DePinho RA, Gilliland DG. The Role of Forkhead Transcription Factors FoxO1, FoxO3 and FoxO4 in Hematopoiesis and Leukemogenesis. Blood. 106: 1350-1350. DOI: 10.1182/Blood.V106.11.1350.1350  0.368
2004 Sarkar-Agrawal P, Vergilis I, Sharpless NE, DePinho RA, Rünger TM. Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. Journal of the National Cancer Institute. 96: 1790-3. PMID 15572761 DOI: 10.1093/Jnci/Djh307  0.342
2004 Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes & Development. 18: 2614-26. PMID 15489287 DOI: 10.1101/Gad.1244004  0.384
2004 Li Z, David G, Hung KW, DePinho RA, Fu AK, Ip NY. Cdk5/p35 phosphorylates mSds3 and regulates mSds3-mediated repression of transcription. The Journal of Biological Chemistry. 279: 54438-44. PMID 15489224 DOI: 10.1074/Jbc.M411002200  0.319
2004 Argilla D, Chin K, Singh M, Hodgson JG, Bosenberg M, de Solórzano CO, Lockett S, DePinho RA, Gray J, Hanahan D. Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes. Cancer Cell. 6: 373-85. PMID 15488760 DOI: 10.1016/J.Ccr.2004.08.032  0.37
2004 Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Molecular and Cellular Biology. 24: 8437-46. PMID 15367665 DOI: 10.1128/Mcb.24.19.8437-8446.2004  0.331
2004 DePinho RA, Polyak K. Cancer chromosomes in crisis. Nature Genetics. 36: 932-4. PMID 15340427 DOI: 10.1038/Ng0904-932  0.374
2004 Maser RS, DePinho RA. Telomeres and the DNA damage response: why the fox is guarding the henhouse. Dna Repair. 3: 979-88. PMID 15279784 DOI: 10.1016/J.Dnarep.2004.05.009  0.306
2004 Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 6: 91-9. PMID 15261145 DOI: 10.1016/J.Ccr.2004.06.007  0.387
2004 Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nature Genetics. 36: 877-82. PMID 15235603 DOI: 10.1038/Ng1389  0.536
2004 Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes & Development. 18: 1533-8. PMID 15231735 DOI: 10.1101/Gad.1199104  0.372
2004 Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Gans JD, Bardeesy N, Cauwels C, Cordon-Cardo C, Redston MS, DePinho RA, Chin L. High-resolution characterization of the pancreatic adenocarcinoma genome. Proceedings of the National Academy of Sciences of the United States of America. 101: 9067-72. PMID 15199222 DOI: 10.1073/Pnas.0402932101  0.624
2004 Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, ... ... DePinho RA, et al. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 5: 375-87. PMID 15093544 DOI: 10.1016/S1535-6108(04)00085-6  0.475
2004 Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proceedings of the National Academy of Sciences of the United States of America. 101: 3329-35. PMID 14985505 DOI: 10.1073/Pnas.0308061100  0.368
2004 Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA. The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene. 23: 379-85. PMID 14724566 DOI: 10.1038/Sj.Onc.1207074  0.346
2004 Sharpless NE, DePinho RA. Telomeres, stem cells, senescence, and cancer. The Journal of Clinical Investigation. 113: 160-8. PMID 14722605 DOI: 10.1172/Jci20761  0.376
2004 Attardi LD, DePinho RA. Conquering the complexity of p53. Nature Genetics. 36: 7-8. PMID 14702030 DOI: 10.1038/Ng0104-7  0.362
2004 Carrasco R, Tonon G, Brennan C, Protopopov A, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Zhan F, Protopopova M, Mitsiades C, Munshi N, Chin L, Bergsagel P, ... ... DePinho R, et al. Comprehensive Genome-Wide Profile of Regional Gains and Losses in Multiple Myeloma Using Array-CGH: The 1q21 Amplification and Potential Role of the BCL-9 Gene in Multiple Myeloma Pathogenesis. Blood. 104: 785-785. DOI: 10.1182/Blood.V104.11.785.785  0.418
2003 Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes & Development. 17: 3112-26. PMID 14681207 DOI: 10.1101/Gad.1158703  0.353
2003 David G, Turner GM, Yao Y, Protopopov A, DePinho RA. mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes & Development. 17: 2396-405. PMID 14522945 DOI: 10.1101/Gad.1109403  0.324
2003 Ossipova O, Bardeesy N, DePinho RA, Green JB. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nature Cell Biology. 5: 889-94. PMID 12973359 DOI: 10.1038/Ncb1048  0.337
2003 Wong KK, DePinho RA. Walking the telomere plank into cancer. Journal of the National Cancer Institute. 95: 1184-6. PMID 12928335 DOI: 10.1093/Jnci/Djg028  0.332
2003 Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science (New York, N.Y.). 301: 215-8. PMID 12855809 DOI: 10.1126/Science.1086336  0.334
2003 D'Amico M, Wu K, Di Vizio D, Reutens AT, Stahl M, Fu M, Albanese C, Russell RG, Muller WJ, White M, Negassa A, Lee HW, DePinho RA, Pestell RG. The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Research. 63: 3395-402. PMID 12810676  0.514
2003 Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood. 102: 517-20. PMID 12663456 DOI: 10.1182/Blood-2002-07-2334  0.317
2003 Gibson SL, Dai CY, Lee HW, DePinho RA, Gee MS, Lee WM, Furth EE, Brensinger C, Enders GH. Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. Cancer Research. 63: 742-6. PMID 12591718  0.478
2003 Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 421: 643-8. PMID 12540856 DOI: 10.1038/Nature01385  0.516
2003 Chang S, Khoo CM, Naylor ML, Maser RS, DePinho RA. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes & Development. 17: 88-100. PMID 12514102 DOI: 10.1101/Gad.1029903  0.585
2002 Bardeesy N, DePinho RA. Pancreatic cancer biology and genetics. Nature Reviews. Cancer. 2: 897-909. PMID 12459728 DOI: 10.1038/Nrc949  0.366
2002 Sharp R, Recio JA, Jhappan C, Otsuka T, Liu S, Yu Y, Liu W, Anver M, Navid F, Helman LJ, DePinho RA, Merlino G. Synergism between INK4a/ARF inactivation and aberrant HGF/SF signaling in rhabdomyosarcomagenesis. Nature Medicine. 8: 1276-80. PMID 12368906 DOI: 10.1038/Nm787  0.376
2002 Chang S, DePinho RA. Telomerase extracurricular activities. Proceedings of the National Academy of Sciences of the United States of America. 99: 12520-2. PMID 12271146 DOI: 10.1073/Pnas.212514699  0.573
2002 Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 419: 162-7. PMID 12226664 DOI: 10.1038/Nature01045  0.353
2002 Maser RS, DePinho RA. Keeping telomerase in its place. Nature Medicine. 8: 934-6. PMID 12205452 DOI: 10.1038/Nm0902-934  0.342
2002 O'Hagan RC, Chang S, Maser RS, Mohan R, Artandi SE, Chin L, DePinho RA. Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell. 2: 149-55. PMID 12204535 DOI: 10.1016/S1535-6108(02)00094-6  0.785
2002 Zhang Z, Wang Y, Herzog CR, Liu G, Lee HW, DePinho RA, You M. A strong candidate gene for the Papg1 locus on mouse chromosome 4 affecting lung tumor progression. Oncogene. 21: 5960-6. PMID 12185599 DOI: 10.1038/Sj.Onc.1205725  0.56
2002 Lund AH, Turner G, Trubetskoy A, Verhoeven E, Wientjens E, Hulsman D, Russell R, DePinho RA, Lenz J, van Lohuizen M. Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice. Nature Genetics. 32: 160-5. PMID 12185367 DOI: 10.1038/Ng956  0.423
2002 Sharpless NE, DePinho RA. p53: good cop/bad cop. Cell. 110: 9-12. PMID 12150992 DOI: 10.1016/S0092-8674(02)00818-8  0.352
2002 Lee CK, Raz R, Gimeno R, Gertner R, Wistinghausen B, Takeshita K, DePinho RA, Levy DE. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity. 17: 63-72. PMID 12150892 DOI: 10.1016/S1074-7613(02)00336-9  0.316
2002 Maser RS, DePinho RA. Connecting chromosomes, crisis, and cancer. Science (New York, N.Y.). 297: 565-9. PMID 12142527 DOI: 10.1126/Science.297.5581.565  0.405
2002 Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 1: 269-77. PMID 12086863 DOI: 10.1016/S1535-6108(02)00046-6  0.342
2002 Artandi SE, Alson S, Tietze MK, Sharpless NE, Ye S, Greenberg RA, Castrillon DH, Horner JW, Weiler SR, Carrasco RD, DePinho RA. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 8191-6. PMID 12034875 DOI: 10.1073/Pnas.112515399  0.677
2002 Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA. Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Molecular and Cellular Biology. 22: 2743-50. PMID 11909966 DOI: 10.1128/Mcb.22.8.2743-2750.2002  0.315
2002 Sviderskaya EV, Hill SP, Evans-Whipp TJ, Chin L, Orlow SJ, Easty DJ, Cheong SC, Beach D, DePinho RA, Bennett DC. p16(Ink4a) in melanocyte senescence and differentiation. Journal of the National Cancer Institute. 94: 446-54. PMID 11904317 DOI: 10.1093/Jnci/94.6.446  0.622
2002 You MJ, Castrillon DH, Bastian BC, O'Hagan RC, Bosenberg MW, Parsons R, Chin L, DePinho RA. Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 1455-60. PMID 11818530 DOI: 10.1073/Pnas.022632099  0.657
2002 Bardeesy N, Morgan J, Sinha M, Signoretti S, Srivastava S, Loda M, Merlino G, DePinho RA. Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. Molecular and Cellular Biology. 22: 635-43. PMID 11756558 DOI: 10.1128/Mcb.22.2.635-643.2002  0.4
2002 Rudolph K, Paraskevi E, DePinho RA. Telomere shortening inhibits progression of hepatoma in telomerase deficient mice Journal of Hepatology. 36: 19. DOI: 10.1016/S0168-8278(02)80053-8  0.306
2001 Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Molecular Cell. 8: 1187-96. PMID 11779495 DOI: 10.1016/S1097-2765(01)00425-7  0.547
2001 Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 413: 86-91. PMID 11544531 DOI: 10.1038/35092592  0.426
2001 Hemann MT, Rudolph KL, Strong MA, DePinho RA, Chin L, Greider CW. Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Molecular Biology of the Cell. 12: 2023-30. PMID 11452000 DOI: 10.1091/Mbc.12.7.2023  0.362
2001 Ranganathan V, Heine WF, Ciccone DN, Rudolph KL, Wu X, Chang S, Hai H, Ahearn IM, Livingston DM, Resnick I, Rosen F, Seemanova E, Jarolim P, DePinho RA, Weaver DT. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Current Biology : Cb. 11: 962-6. PMID 11448772 DOI: 10.1016/S0960-9822(01)00267-6  0.52
2001 Chang S, Khoo C, DePinho RA. Modeling chromosomal instability and epithelial carcinogenesis in the telomerase-deficient mouse. Seminars in Cancer Biology. 11: 227-39. PMID 11407947 DOI: 10.1006/Scbi.2000.0374  0.57
2001 Bardeesy N, Sharpless NE, DePinho RA, Merlino G. The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model. Seminars in Cancer Biology. 11: 201-18. PMID 11407945 DOI: 10.1006/Scbi.2000.0371  0.378
2001 DePinho RA, Jacks T. Introduction. The laboratory mouse in cancer research. Seminars in Cancer Biology. 11: 175-6. PMID 11407942 DOI: 10.1006/Scbi.2000.0369  0.305
2001 Kucherlapati R, DePinho RA. Cancer. Telomerase meets its mismatch. Nature. 411: 647-8. PMID 11395749 DOI: 10.1038/35079715  0.378
2001 Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. Malignant glioma: genetics and biology of a grave matter. Genes & Development. 15: 1311-33. PMID 11390353 DOI: 10.1101/Gad.891601  0.356
2001 Rudolph KL, Millard M, Bosenberg MW, DePinho RA. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nature Genetics. 28: 155-9. PMID 11381263 DOI: 10.1038/88871  0.415
2001 Martelli F, Hamilton T, Silver DP, Sharpless NE, Bardeesy N, Rokas M, DePinho RA, Livingston DM, Grossman SR. p19ARF targets certain E2F species for degradation. Proceedings of the National Academy of Sciences of the United States of America. 98: 4455-60. PMID 11274364 DOI: 10.1073/Pnas.081061398  0.372
2001 Lee KH, Rudolph KL, Ju YJ, Greenberg RA, Cannizzaro L, Chin L, Weiler SR, DePinho RA. Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 3381-6. PMID 11248087 DOI: 10.1073/Pnas.051629198  0.414
2001 Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L. Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Molecular and Cellular Biology. 21: 2144-53. PMID 11238948 DOI: 10.1128/Mcb.21.6.2144-2153.2001  0.351
2001 de Alboran IM, O'Hagan RC, Gärtner F, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 14: 45-55. PMID 11163229 DOI: 10.1016/S1074-7613(01)00088-7  0.508
2001 Raveh T, Droguett G, Horwitz MS, DePinho RA, Kimchi A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nature Cell Biology. 3: 1-7. PMID 11146619 DOI: 10.1038/35050500  0.331
2001 Zhang SL, DuBois W, Ramsay ES, Bliskovski V, Morse HC, Taddesse-Heath L, Vass WC, DePinho RA, Mock BA. Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility. Molecular and Cellular Biology. 21: 310-8. PMID 11113205 DOI: 10.1128/Mcb.21.1.310-318.2001  0.315
2001 Dai CY, Steven L. G, Gee MS, Lee WM, Lee H, Depinho RA, Enders GH. Suppression of mouse colon tumor angiogenesis by the INK4a/ARF locus Gastroenterology. 120: A296. DOI: 10.1016/S0016-5085(08)81469-2  0.534
2000 Ferguson DO, Sekiguchi JM, Frank KM, Gao Y, Sharpless NE, Gu Y, Manis J, DePinho RA, Alt FW. The interplay between nonhomologous end-joining and cell cycle checkpoint factors in development, genomic stability, and tumorigenesis. Cold Spring Harbor Symposia On Quantitative Biology. 65: 395-403. PMID 12760055 DOI: 10.1101/Sqb.2000.65.395  0.472
2000 Chang MA, Horner JW, Conklin BR, DePinho RA, Bok D, Zack DJ. Tetracycline-inducible system for photoreceptor-specific gene expression. Investigative Ophthalmology & Visual Science. 41: 4281-7. PMID 11095627  0.474
2000 DePinho RA. The age of cancer. Nature. 408: 248-54. PMID 11089982 DOI: 10.1038/35041694  0.341
2000 Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nature Genetics. 26: 85-8. PMID 10973255 DOI: 10.1038/79232  0.793
2000 O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes & Development. 14: 2185-91. PMID 10970882 DOI: 10.1101/Gad.827200  0.527
2000 Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, DePinho RA. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 406: 641-5. PMID 10949306 DOI: 10.1038/35020592  0.735
2000 Artandi SE, DePinho RA. Mice without telomerase: what can they teach us about human cancer? Nature Medicine. 6: 852-5. PMID 10932211 DOI: 10.1038/78595  0.664
2000 Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Molecular Cell. 5: 993-1002. PMID 10911993 DOI: 10.1016/S1097-2765(00)80264-6  0.478
2000 Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes & Development. 14: 1390-9. PMID 10837031 DOI: 10.1101/Gad.14.11.1390  0.505
2000 Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proceedings of the National Academy of Sciences of the United States of America. 97: 6630-3. PMID 10823907 DOI: 10.1073/Pnas.110152897  0.612
2000 Bardeesy N, Wong KK, DePinho RA, Chin L. Animal models of melanoma: recent advances and future prospects. Advances in Cancer Research. 79: 123-56. PMID 10818679 DOI: 10.1016/S0065-230X(00)79004-X  0.374
2000 Gagandeep S, Ott M, Nisen PD, DePinho RA, Gupta S. Overexpression of Mad transcription factor inhibits proliferation of cultured human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals. The Journal of Gene Medicine. 2: 117-27. PMID 10809145 DOI: 10.1002/(Sici)1521-2254(200003/04)2:2<117::Aid-Jgm96>3.0.Co;2-X  0.399
2000 Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature. 404: 897-900. PMID 10786799 DOI: 10.1038/35009138  0.708
2000 Albanese C, Reutens AT, Bouzahzah B, Fu M, D'Amico M, Link T, Nicholson R, Depinho RA, Pestell RG. Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 877-84. PMID 10783141 DOI: 10.1096/Fasebj.14.7.877  0.348
2000 Chin L, DePinho RA. Flipping the oncogene switch: illumination of tumor maintenance and regression. Trends in Genetics : Tig. 16: 147-50. PMID 10729826 DOI: 10.1016/S0168-9525(99)01968-X  0.419
2000 Artandi SE, DePinho RA. A critical role for telomeres in suppressing and facilitating carcinogenesis. Current Opinion in Genetics & Development. 10: 39-46. PMID 10679392 DOI: 10.1016/S0959-437X(99)00047-7  0.679
2000 Rudolph KL, Chang S, Millard M, Schreiber-Agus N, DePinho RA. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science (New York, N.Y.). 287: 1253-8. PMID 10678830 DOI: 10.1126/Science.287.5456.1253  0.473
2000 O'Hagan RC, Schreiber-Agus N, Chen K, David G, Engelman JA, Schwab R, Alland L, Thomson C, Ronning DR, Sacchettini JC, Meltzer P, DePinho RA. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. Nature Genetics. 24: 113-9. PMID 10655054 DOI: 10.1038/72761  0.357
2000 Shen-Li H, O'Hagan RC, Hou H, Horner JW, Lee HW, DePinho RA. Essential role for Max in early embryonic growth and development. Genes & Development. 14: 17-22. PMID 10640271 DOI: 10.1101/Gad.14.1.17  0.484
1999 Gopalkrishnan RV, Christiansen KA, Goldstein NI, DePinho RA, Fisher PB. Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells. Nucleic Acids Research. 27: 4775-82. PMID 10572178 DOI: 10.1093/Nar/27.24.4775  0.366
1999 DePinho RA, Jacks T. A bumper crop of cancer genes. Nature Genetics. 23: 253-4. PMID 10545932 DOI: 10.1038/15423  0.335
1999 Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Essential role for oncogenic Ras in tumour maintenance. Nature. 400: 468-72. PMID 10440378 DOI: 10.1038/22788  0.515
1999 Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 97: 527-38. PMID 10338216 DOI: 10.1016/S0092-8674(00)80762-X  0.663
1999 Greenberg RA, Chin L, Femino A, Lee KH, Gottlieb GJ, Singer RH, Greider CW, DePinho RA. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell. 97: 515-25. PMID 10338215 DOI: 10.1016/S0092-8674(00)80761-8  0.463
1999 FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE. Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. Oncogene. 18: 2489-98. PMID 10229200 DOI: 10.1038/Sj.Onc.1202611  0.348
1999 Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 96: 701-12. PMID 10089885 DOI: 10.1016/S0092-8674(00)80580-2  0.614
1999 de Lange T, DePinho RA. Unlimited mileage from telomerase? Science (New York, N.Y.). 283: 947-9. PMID 10075559 DOI: 10.1126/Science.283.5404.947  0.385
1999 Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Current Opinion in Genetics & Development. 9: 22-30. PMID 10072356 DOI: 10.1016/S0959-437X(99)80004-5  0.391
1999 Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene. 18: 1219-26. PMID 10022128 DOI: 10.1038/Sj.Onc.1202669  0.382
1999 Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 397: 164-8. PMID 9923679 DOI: 10.1038/16476  0.378
1999 Gómez Lahoz E, Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RA. Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo. Molecular and Cellular Biology. 19: 353-63. PMID 9858559 DOI: 10.1128/Mcb.19.1.353  0.306
1998 Holland EC, Hively WP, DePinho RA, Varmus HE. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes & Development. 12: 3675-85. PMID 9851974 DOI: 10.1101/Gad.12.23.3675  0.378
1998 Auer KL, Park JS, Seth P, Coffey RJ, Darlington G, Abo A, McMahon M, Depinho RA, Fisher PB, Dent P. Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. The Biochemical Journal. 336: 551-60. PMID 9841865 DOI: 10.1042/Bj3360551  0.328
1998 Chin L, Merlino G, DePinho RA. Malignant melanoma: modern black plague and genetic black box. Genes & Development. 12: 3467-81. PMID 9832500 DOI: 10.1101/Gad.12.22.3467  0.371
1998 Schreiber-Agus N, DePinho RA. Repression by the Mad(Mxi1)-Sin3 complex. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 20: 808-18. PMID 9819568 DOI: 10.1002/(Sici)1521-1878(199810)20:10<808::Aid-Bies6>3.0.Co;2-U  0.327
1998 Radfar A, Unnikrishnan I, Lee HW, DePinho RA, Rosenberg N. p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. Proceedings of the National Academy of Sciences of the United States of America. 95: 13194-9. PMID 9789064 DOI: 10.1073/Pnas.95.22.13194  0.533
1998 Zhang P, Wong C, DePinho RA, Harper JW, Elledge SJ. Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes & Development. 12: 3162-7. PMID 9784491 DOI: 10.1101/Gad.12.20.3162  0.355
1998 Chin L, Pomerantz J, DePinho RA. The INK4a/ARF tumor suppressor: one gene--two products--two pathways. Trends in Biochemical Sciences. 23: 291-6. PMID 9757829 DOI: 10.1016/S0968-0004(98)01236-5  0.4
1998 Schreiber-Agus N, Meng Y, Hoang T, Hou H, Chen K, Greenberg R, Cordon-Cardo C, Lee HW, DePinho RA. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature. 393: 483-7. PMID 9624006 DOI: 10.1038/31008  0.586
1998 Greenberg RA, Allsopp RC, Chin L, Morin GB, DePinho RA. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 16: 1723-30. PMID 9582020 DOI: 10.1038/Sj.Onc.1201933  0.361
1998 Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature. 392: 569-74. PMID 9560153 DOI: 10.1038/33345  0.534
1998 Pomerantz J, Schreiber-Agus N, Liégeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, DePinho RA. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell. 92: 713-23. PMID 9529248 DOI: 10.1016/S0092-8674(00)81400-2  0.541
1998 DePinho RA. Transcriptional repression. The cancer-chromatin connection. Nature. 391: 533, 535-6. PMID 9468130 DOI: 10.1038/35257  0.374
1998 Watanabe H, Pan ZQ, Schreiber-Agus N, DePinho RA, Hurwitz J, Xiong Y. Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57(KIP2) requires binding to proliferating cell nuclear antigen Proceedings of the National Academy of Sciences of the United States of America. 95: 1392-1397. PMID 9465025 DOI: 10.1073/Pnas.95.4.1392  0.331
1997 Blasco MA, Lee HW, Rizen M, Hanahan D, DePinho R, Greider CW. Mouse models for the study of telomerase. Ciba Foundation Symposium. 211: 160-70; discussion 1. PMID 9524757  0.457
1997 Chin L, Pomerantz J, Polsky D, Jacobson M, Cohen C, Cordon-Cardo C, Horner JW, DePinho RA. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes & Development. 11: 2822-34. PMID 9353252 DOI: 10.1101/Gad.11.21.2822  0.419
1997 Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 91: 25-34. PMID 9335332 DOI: 10.1016/S0092-8674(01)80006-4  0.563
1997 Schreiber-Agus N, Alland L, Muhle R, Goltz J, Chen K, Stevens L, Stein D, DePinho RA. A biochemical and biological analysis of Myc superfamily interactions. Current Topics in Microbiology and Immunology. 224: 159-68. PMID 9308239 DOI: 10.1007/978-3-642-60801-8_16  0.339
1997 Zhang P, Liégeois NJ, Wong C, Finegold M, Hou H, Thompson JC, Silverman A, Harper JW, DePinho RA, Elledge SJ. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature. 387: 151-8. PMID 9144284 DOI: 10.1038/387151A0  0.36
1997 Alland L, Muhle R, Hou H, Potes J, Chin L, Schreiber-Agus N, DePinho RA. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature. 387: 49-55. PMID 9139821 DOI: 10.1038/387049A0  0.308
1997 Schreiber-Agus N, Stein D, Chen K, Goltz JS, Stevens L, DePinho RA. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proceedings of the National Academy of Sciences of the United States of America. 94: 1235-40. PMID 9037036 DOI: 10.1073/Pnas.94.4.1235  0.396
1996 Hatton KS, Mahon K, Chin L, Chiu FC, Lee HW, Peng D, Morgenbesser SD, Horner J, DePinho RA. Expression and activity of L-Myc in normal mouse development. Molecular and Cellular Biology. 16: 1794-804. PMID 8657155 DOI: 10.1128/Mcb.16.4.1794  0.506
1996 Serrano M, Lee HW, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality Cell. 85: 27-37. PMID 8620534 DOI: 10.1016/S0092-8674(00)81079-X  0.609
1996 Liégeois NJ, Horner JW, DePinho RA. Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 93: 1303-7. PMID 8577759 DOI: 10.1073/Pnas.93.3.1303  0.382
1995 Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, Guida P, Skoultchi AI, DePinho RA. An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell. 80: 777-86. PMID 7889571 DOI: 10.1016/0092-8674(95)90356-9  0.324
1995 Chin L, Schreiber-Agus N, Pellicer I, Chen K, Lee HW, Dudast M, Cordon-Cardo C, DePinho RA. Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 92: 8488-92. PMID 7667316 DOI: 10.1073/Pnas.92.18.8488  0.564
1995 Bali D, Svetlanov A, Lee HW, Fusco-DeMane D, Leiser M, Li B, Barzilai N, Surana M, Hou H, Fleischer N, DePinho R, Rossetti L, Efrat S. Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene Journal of Biological Chemistry. 270: 21464-21467. PMID 7665557 DOI: 10.1074/Jbc.270.37.21464  0.473
1995 Chen J, Willingham T, Margraf LR, Schreiber-Agus N, DePinho RA, Nisen PD. Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells. Nature Medicine. 1: 638-43. PMID 7585143 DOI: 10.1038/Nm0795-638  0.386
1995 Morgenbesser S, Schreiber-Agus N, Bidder M, Mahon K, Overbeek P, Horner J, DePinho R. Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. The Embo Journal. 14: 743-756. DOI: 10.1002/J.1460-2075.1995.Tb07053.X  0.33
1994 Lahoz EG, Xu L, Schreiber-Agus N, DePinho RA. Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1. Proceedings of the National Academy of Sciences of the United States of America. 91: 5503-7. PMID 8202517 DOI: 10.1073/Pnas.91.12.5503  0.355
1994 Morgenbesser SD, Williams BO, Jacks T, Depinho RA. P53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens Nature. 371: 72-74. PMID 8072529 DOI: 10.1038/371072A0  0.399
1993 Schreiber-Agus N, Horner J, Torres R, Chiu FC, DePinho RA. Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution. Molecular and Cellular Biology. 13: 2765-75. PMID 8474440 DOI: 10.1128/Mcb.13.5.2765  0.356
1993 Schreiber-Agus N, Torres R, Horner J, Lau A, Jamrich M, DePinho RA. Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs. Molecular and Cellular Biology. 13: 2456-68. PMID 8455622 DOI: 10.1128/Mcb.13.4.2456  0.347
1992 Mukherjee B, Morgenbesser SD, DePinho RA. Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants. Genes & Development. 6: 1480-92. PMID 1644290 DOI: 10.1101/Gad.6.8.1480  0.348
1992 Torres R, Schreiber-Agus N, Morgenbesser SD, DePinho RA. Myc and Max: a putative transcriptional complex in search of a cellular target. Current Opinion in Cell Biology. 4: 468-74. PMID 1497918 DOI: 10.1016/0955-0674(92)90013-3  0.358
1991 DeFranco D, Bali D, Torres R, DePinho RA, Erickson RP, Gluecksohn-Waelsch S. The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression. Proceedings of the National Academy of Sciences of the United States of America. 88: 5607-10. PMID 2062840 DOI: 10.1073/Pnas.88.13.5607  0.353
1991 Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 65: 663-75. PMID 2032290 DOI: 10.1016/0092-8674(91)90098-J  0.47
1991 DePinho RA, Schreiber-Agus N, Alt FW. myc family oncogenes in the development of normal and neoplastic cells. Advances in Cancer Research. 57: 1-46. PMID 1950701 DOI: 10.1016/S0065-230X(08)60994-X  0.506
1991 Shin SU, DePinho R, Zack DJ, Rudikoff S, Scharff MD. Instability of immunoglobulin genes in S107 cell line. Somatic Cell and Molecular Genetics. 17: 259-76. PMID 1904631 DOI: 10.1007/Bf01232821  0.66
1991 Xu L, Morgenbesser SD, DePinho RA. Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver. Molecular and Cellular Biology. 11: 6007-15. PMID 1719378 DOI: 10.1128/Mcb.11.12.6007  0.327
1990 Zimmerman K, Legouy E, Stewart V, Depinho R, Alt FW. Differential regulation of the N-myc gene in transfected cells and transgenic mice. Molecular and Cellular Biology. 10: 2096-103. PMID 2183019 DOI: 10.1128/Mcb.10.5.2096  0.505
1990 Möröy T, Fisher P, Guidos C, Ma A, Zimmerman K, Tesfaye A, DePinho R, Weissman I, Alt FW. IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis. The Embo Journal. 9: 3659-3666. DOI: 10.1002/J.1460-2075.1990.Tb07577.X  0.51
1989 Dildrop R, Ma A, Zimmerman K, Hsu E, Tesfaye A, DePinho R, Alt FW. IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. The Embo Journal. 8: 1121-1128. DOI: 10.1002/J.1460-2075.1989.Tb03482.X  0.423
1988 Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW. Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Current Topics in Microbiology and Immunology. 141: 100-9. PMID 3215042 DOI: 10.1007/978-3-642-74006-0_14  0.533
1987 DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes & Development. 1: 1311-26. PMID 3322939 DOI: 10.1101/Gad.1.10.1311  0.586
1987 Scharff MD, Aguila HL, Behar SM, Chien NC, DePinho R, French DL, Pollock RR, Shin SU. Studies on the somatic instability of immunoglobulin genes in vivo and in cultured cells. Immunological Reviews. 96: 75-90. PMID 3298011 DOI: 10.1111/J.1600-065X.1987.Tb00510.X  0.688
1987 DePinho R, Mitsock L, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P. Myc family of cellular oncogenes. Journal of Cellular Biochemistry. 33: 257-66. PMID 3034933 DOI: 10.1002/Jcb.240330404  0.506
1987 Legouy E, DePinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, Kriz R, Alt FW. Structure and expression of the murine L-myc gene. The Embo Journal. 6: 3359-66. PMID 2828024  0.54
1986 Depinho RA, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Alt F. Myc family genes: a dispersed multi-gene family. Annals of Clinical Research. 18: 284-9. PMID 3551773  0.506
1986 DePinho RA, Legouy E, Feldman LB, Kohl NE, Yancopoulos GD, Alt FW. Structure and expression of the murine N-myc gene. Proceedings of the National Academy of Sciences of the United States of America. 83: 1827-31. PMID 3513190 DOI: 10.1002/J.1460-2075.1987.Tb02657.X  0.594
1986 Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature. 319: 73-7. PMID 3510398 DOI: 10.1038/319073A0  0.481
1986 Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature. 322: 179-81. PMID 3487737 DOI: 10.1038/322179A0  0.448
1986 Scharff MD, DePinho RA, Behar S, Beychok C, Shin SU, French D. The role of monoclonal antibodies and the recombinant DNA technology in studying autoantibody production. Cellular Immunology. 99: 29-37. PMID 3093101 DOI: 10.1016/0008-8749(86)90212-1  0.655
1986 Alt FW, Blackwell TK, DePinho RA, Reth MG, Yancopoulos GD. Regulation of genome rearrangement events during lymphocyte differentiation. Immunological Reviews. 89: 5-30. PMID 3081433  0.577
1986 DePinho RA, Feldman LB, Scharff MD. Tailor-made monoclonal antibodies. Annals of Internal Medicine. 104: 225-33. PMID 3080934 DOI: 10.7326/0003-4819-104-2-225  0.476
1986 Alt FW, DePinho R, Zimmerman K, Legouy E, Hatton K, Ferrier P, Tesfaye A, Yancopoulos G, Nisen P. The human myc gene family. Cold Spring Harbor Symposia On Quantitative Biology. 51: 931-41. PMID 3034500 DOI: 10.1101/Sqb.1986.051.01.106  0.569
1986 Yancopoulos GD, DePinho RA, Zimmerman KA, Lutzker SG, Rosenberg N, Alt FW. Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. The Embo Journal. 5: 3259-66. PMID 3028778 DOI: 10.1002/J.1460-2075.1986.Tb04637.X  0.589
1984 DePinho R, Kruger K, Andrews N, Lutzker S, Baltimore D, Alt FW. Molecular basis of heavy-chain class switching and switch region deletion in an Abelson virus-transformed cell line. Molecular and Cellular Biology. 4: 2905-10. PMID 6098827 DOI: 10.1128/Mcb.4.12.2905  0.568
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