Louis B. Hersh - Publications

Affiliations: 
University of Kentucky, Lexington, KY 
Area:
Biochemistry

125 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Song ES, Rodgers DW, Hersh LB. Insulin-degrading enzyme is not secreted from cultured cells. Scientific Reports. 8: 2335. PMID 29402917 DOI: 10.1038/S41598-018-20597-6  0.351
2017 Song ES, Jang H, Guo HF, Juliano MA, Juliano L, Morris AJ, Galperin E, Rodgers DW, Hersh LB. Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes. Proceedings of the National Academy of Sciences of the United States of America. PMID 28325868 DOI: 10.1073/Pnas.1613447114  0.355
2016 Verma N, Ly H, Liu M, Chen J, Zhu H, Chow M, Hersh LB, Despa F. Intraneuronal Amylin Deposition Peroxidative Membrane Injury and Increased IL-1β Synthesis in Brains of Alzheimer's Disease Patients with Type-2 Diabetes and in Diabetic HIP Rats. Journal of Alzheimer's Disease : Jad. PMID 27163815 DOI: 10.3233/Jad-160047  0.32
2015 Guan H, Chow KM, Song E, Verma N, Despa F, Hersh LB. The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells. Plos One. 10: e0133263. PMID 26191799 DOI: 10.1371/Journal.Pone.0133263  0.577
2015 Song ES, Ozbil M, Zhang T, Sheetz M, Lee D, Tran D, Li S, Prabhakar R, Hersh LB, Rodgers DW. An Extended Polyanion Activation Surface in Insulin Degrading Enzyme. Plos One. 10: e0133114. PMID 26186535 DOI: 10.1371/Journal.Pone.0133114  0.343
2015 Chin-Chan M, Segovia J, Quintanar L, Arcos-López T, Hersh LB, Chow KM, Rodgers DW, Quintanilla-Vega B. Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 145: 128-37. PMID 25673500 DOI: 10.1093/Toxsci/Kfv037  0.348
2015 Guan H, Chow KM, Song E, Verma N, Despa F, Hersh LB. The mitochondrial peptidase pitrilysin degrades islet amyloid polypeptide in beta-cells Plos One. 10. DOI: 10.1371/journal.pone.0133263  0.496
2012 Song ES, Melikishvili M, Fried MG, Juliano MA, Juliano L, Rodgers DW, Hersh LB. Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation. Plos One. 7: e46790. PMID 23077523 DOI: 10.1371/Journal.Pone.0046790  0.321
2012 Guan H, Chow KM, Shah R, Rhodes CJ, Hersh LB. Degradation of islet amyloid polypeptide by neprilysin. Diabetologia. 55: 2989-98. PMID 22898766 DOI: 10.1007/S00125-012-2678-Y  0.559
2012 Sexton T, Hitchcook LJ, Rodgers DW, Bradley LH, Hersh LB. Active site mutations change the cleavage specificity of neprilysin. Plos One. 7: e32343. PMID 22384224 DOI: 10.1371/Journal.Pone.0032343  0.331
2012 Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. BACE2 expression increases in human neurodegenerative disease. The American Journal of Pathology. 180: 337-50. PMID 22074738 DOI: 10.1016/J.Ajpath.2011.09.034  0.351
2012 Noinaj N, Song ES, Bhasin S, Alper BJ, Schmidt WK, Hersh LB, Rodgers DW. Anion activation site of insulin-degrading enzyme. The Journal of Biological Chemistry. 287: 48-57. PMID 22049080 DOI: 10.1074/Jbc.M111.264614  0.359
2011 Noinaj N, Bhasin SK, Song ES, Scoggin KE, Juliano MA, Juliano L, Hersh LB, Rodgers DW. Identification of the allosteric regulatory site of insulysin. Plos One. 6: e20864. PMID 21731629 DOI: 10.1371/Journal.Pone.0020864  0.353
2011 Song ES, Rodgers DW, Hersh LB. Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism. The Journal of Biological Chemistry. 286: 13852-8. PMID 21343292 DOI: 10.1074/Jbc.M110.191668  0.347
2010 Chow KM, Guan H, Hersh LB. Aminopeptidases do not directly degrade tau protein. Molecular Neurodegeneration. 5: 48. PMID 21054848 DOI: 10.1186/1750-1326-5-48  0.56
2010 Liu Y, Studzinski C, Beckett T, Murphy MP, Klein RL, Hersh LB. Circulating neprilysin clears brain amyloid. Molecular and Cellular Neurosciences. 45: 101-7. PMID 20558294 DOI: 10.1016/J.Mcn.2010.05.014  0.314
2010 Song ES, Rodgers DW, Hersh LB. A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties Plos One. 5. PMID 20300529 DOI: 10.1371/Journal.Pone.0009719  0.318
2009 Liu Y, Studzinski C, Beckett T, Guan H, Hersh MA, Murphy MP, Klein R, Hersh LB. Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1381-6. PMID 19471248 DOI: 10.1038/Mt.2009.115  0.582
2009 Chow KM, Gakh O, Payne IC, Juliano MA, Juliano L, Isaya G, Hersh LB. Mammalian pitrilysin: substrate specificity and mitochondrial targeting. Biochemistry. 48: 2868-77. PMID 19196155 DOI: 10.1021/Bi8016125  0.335
2009 Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1115-25. PMID 19176820 DOI: 10.1523/Jneurosci.4220-08.2009  0.366
2009 Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. Journal of Neuroscience Research. 87: 1462-73. PMID 19021293 DOI: 10.1002/Jnr.21944  0.6
2008 Hersh LB, Rodgers DW. Neprilysin and amyloid beta peptide degradation Current Alzheimer Research. 5: 225-231. PMID 18393807 DOI: 10.2174/156720508783954703  0.364
2008 Horiguchi A, Chen DY, Goodman OB, Zheng R, Shen R, Guan H, Hersh LB, Nanus DM. Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis. Prostate Cancer and Prostatic Diseases. 11: 79-87. PMID 17563767 DOI: 10.1038/Sj.Pcan.4500984  0.54
2008 Liu Y, Guan H, Klein RL, Oddo S, LaFerla FM, Murphy MP, Hersh LB. P2-343: Peripherally overexpessed neprilysin in muscle reduces brain amyloid in a transgenic mouse model of AD Alzheimer's & Dementia. 4: T473-T473. DOI: 10.1016/J.Jalz.2008.05.1420  0.545
2007 Liu Y, Guan H, Beckett TL, Juliano MA, Juliano L, Song ES, Chow KM, Murphy MP, Hersh LB. In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides. 28: 2348-55. PMID 17988763 DOI: 10.1016/J.Peptides.2007.09.015  0.574
2007 Horiguchi A, Zheng R, Goodman OB, Shen R, Guan H, Hersh LB, Nanus DM. Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth. Cancer Gene Therapy. 14: 583-9. PMID 17415380 DOI: 10.1038/Sj.Cgt.7701047  0.556
2007 Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/Jbc.M609168200  0.312
2007 Horiguchi A, Shen R, Zheng R, Goodman OB, Guan H, Hersh LB, Nanus DM. 149: Lentiviral Vector Neutral Endopeptidase Gene Transfer Suppresses Prostate Cancer Tumor Growth The Journal of Urology. 177: 51-51. DOI: 10.1016/S0022-5347(18)30414-2  0.497
2006 Song ES, Cady C, Fried MG, Hersh LB. Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation. Biochemistry. 45: 15085-91. PMID 17154546 DOI: 10.1021/Bi061298U  0.357
2006 Daily A, Nath A, Hersh LB. Tat peptides inhibit neprilysin. Journal of Neurovirology. 12: 153-60. PMID 16877296 DOI: 10.1080/13550280600760677  0.311
2006 Hersh LB, Guan H, Daily A, Murphy MP, Oddo S, LaFerla FM. O2-05-01: Peripheral expression of neprilysin decreases amyloid deposition in hAPP mice Alzheimer's & Dementia. 2: S39-S40. DOI: 10.1016/J.Jalz.2006.05.138  0.529
2005 Song ES, Hersh LB. Insulysin: an allosteric enzyme as a target for Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 25: 201-6. PMID 15800373 DOI: 10.1385/Jmn:25:3:201  0.359
2005 Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell. 120: 701-13. PMID 15766532 DOI: 10.1016/J.Cell.2005.01.015  0.336
2005 Song ES, Daily A, Fried MG, Juliano MA, Juliano L, Hersh LB. Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions. The Journal of Biological Chemistry. 280: 17701-6. PMID 15749695 DOI: 10.1074/Jbc.M501896200  0.343
2004 Song ES, Juliano MA, Juliano L, Fried MG, Wagner SL, Hersh LB. ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. The Journal of Biological Chemistry. 279: 54216-20. PMID 15494400 DOI: 10.1074/Jbc.M411177200  0.347
2004 Huang J, Guan H, Booze RM, Eckman CB, Hersh LB. Estrogen regulates neprilysin activity in rat brain. Neuroscience Letters. 367: 85-7. PMID 15308303 DOI: 10.1016/J.Neulet.2004.05.085  0.578
2004 Cai Y, Cronin CN, Engel AG, Ohno K, Hersh LB, Rodgers DW. Choline acetyltransferase structure reveals distribution of mutations that cause motor Embo Journal. 23: 2047-2058. PMID 15131697 DOI: 10.1038/Sj.Emboj.7600221  0.543
2004 Shimojo M, Hersh LB. Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF). Life Sciences. 74: 2213-25. PMID 15017977 DOI: 10.1016/J.Lfs.2003.08.045  0.302
2004 Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. Neprilysin regulates amyloid Beta peptide levels. Journal of Molecular Neuroscience : Mn. 22: 5-11. PMID 14742905 DOI: 10.1385/Jmn:22:1-2:5  0.602
2004 Marr RA, Rockenstien E, Kindy MS, Hersh LB, Gage FH, Masliah E, Verma IM. 525. Therapy for Alzheimer's disease by neprilysin gene transfer Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.470  0.334
2003 Thompson MW, Hersh LB. Analysis of conserved residues of the human puromycin-sensitive aminopeptidase. Peptides. 24: 1359-65. PMID 14706550 DOI: 10.1016/J.Peptides.2003.07.012  0.333
2003 Song ES, Juliano MA, Juliano L, Hersh LB. Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development. The Journal of Biological Chemistry. 278: 49789-94. PMID 14527953 DOI: 10.1074/Jbc.M308983200  0.377
2003 Ma Z, Daquin A, Yao J, Rodgers D, Thompson MW, Hersh LB. Proteolytic cleavage of the puromycin-sensitive aminopeptidase generates a substrate binding domain. Archives of Biochemistry and Biophysics. 415: 80-6. PMID 12801515 DOI: 10.1016/S0003-9861(03)00200-5  0.317
2003 Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB, Thiele DL. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 6221-6. PMID 12732730 DOI: 10.1073/Pnas.1031520100  0.362
2003 Thompson MW, Govindaswami M, Hersh LB. Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein. Archives of Biochemistry and Biophysics. 413: 236-42. PMID 12729622 DOI: 10.1016/S0003-9861(03)00123-1  0.315
2003 Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1992-6. PMID 12657655 DOI: 10.1523/Jneurosci.23-06-01992.2003  0.345
2003 Hersh LB, Shimojo M. Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor. Life Sciences. 72: 2021-8. PMID 12628452 DOI: 10.1016/S0024-3205(03)00065-1  0.301
2003 Hersh LB. Peptidases, proteases and amyloid beta-peptide catabolism. Current Pharmaceutical Design. 9: 449-54. PMID 12570808 DOI: 10.2174/1381612033391676  0.342
2002 Mukherjee A, Hersh LB. Regulation of amyloid beta-peptide levels by enzymatic degradation. Journal of Alzheimer's Disease : Jad. 4: 341-8. PMID 12446966 DOI: 10.3233/Jad-2002-4501  0.34
2001 Lee JH, Chai YG, Hersh LB. Expression patterns of mouse repressor element-1 silencing transcription factor 4 (REST4) and its possible function in neuroblastoma. Journal of Molecular Neuroscience : Mn. 15: 205-14. PMID 11303784 DOI: 10.1385/Jmn:15:3:205  0.317
2000 Lian W, Chen G, Wu D, Brown CK, Madauss K, Hersh LB, Rodgers DW. Crystallization and preliminary analysis of neurolysin Acta Crystallographica Section D: Biological Crystallography. 56: 1644-1646. PMID 11092934 DOI: 10.1107/S0907444900012683  0.339
2000 Stoltze L, Schirle M, Schwarz G, Schröter C, Thompson MW, Hersh LB, Kalbacher H, Stevanovic S, Rammensee HG, Schild H. Two new proteases in the MHC class I processing pathway. Nature Immunology. 1: 413-8. PMID 11062501 DOI: 10.1038/80852  0.304
2000 Mukherjee A, Song E, Kihiko-Ehmann M, Goodman JP, Pyrek JS, Estus S, Hersh LB. Insulysin Hydrolyzes Amyloid β Peptides to Products That Are Neither Neurotoxic Nor Deposit on Amyloid Plaques The Journal of Neuroscience. 20: 8745-8749. DOI: 10.1523/Jneurosci.20-23-08745.2000  0.363
1999 Holt DJ, Herman MM, Hyde TM, Kleinman JE, Sinton CM, German DC, Hersh LB, Graybiel AM, Saper CB. Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia. Neuroscience. 94: 21-31. PMID 10613493 DOI: 10.1016/S0306-4522(99)00279-1  0.305
1999 Shimojo M, Paquette AJ, Anderson DJ, Hersh LB. Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST. Molecular and Cellular Biology. 19: 6788-95. PMID 10490617 DOI: 10.1128/Mcb.19.10.6788  0.301
1999 Manaye KF, Zweig R, Wu D, Hersh LB, De Lacalle S, Saper CB, German DC. Quantification of cholinergic and select non-cholinergic mesopontine neuronal populations in the human brain. Neuroscience. 89: 759-70. PMID 10199611 DOI: 10.1016/S0306-4522(98)00380-7  0.309
1999 Csuhai E, Juliano MA, Pyrek JS, Harms AC, Juliano L, Hersh LB. New fluorogenic substrates for N-arginine dibasic convertase Analytical Biochemistry. 269: 149-154. PMID 10094786 DOI: 10.1006/Abio.1999.4033  0.316
1999 Csuhai E, Juliano MA, Juliano L, Hersh LB. Kinetic analysis of spermine binding to NRD convertase. Archives of Biochemistry and Biophysics. 362: 291-300. PMID 9989938 DOI: 10.1006/Abbi.1998.1029  0.333
1998 Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. The Journal of Biological Chemistry. 273: 32730-8. PMID 9830016 DOI: 10.1074/Jbc.273.49.32730  0.376
1998 Ohkubo K, Baraniuk JN, Hohman R, Merida M, Hersh LB, Kaliner MA. Aminopeptidase activity in human nasal mucosa. The Journal of Allergy and Clinical Immunology. 102: 741-50. PMID 9819290 DOI: 10.1016/S0091-6749(98)70013-2  0.31
1998 Shimojo M, Wu D, Hersh LB. The cholinergic gene locus is coordinately regulated by protein kinase A II in PC12 cells. Journal of Neurochemistry. 71: 1118-26. PMID 9721736 DOI: 10.1046/J.1471-4159.1998.71031118.X  0.309
1998 Thiele DL, Sarada B, Dang T, Safavi A, Hersh LB, Cottam GL. Regulated expression of an endopeptidase that hydrolyses beta-endorphin during differentiation of macrophages and T cells. Advances in Experimental Medicine and Biology. 437: 291-300. PMID 9666282 DOI: 10.1007/978-1-4615-5347-2_32  0.312
1998 Tanaka H, Zhao Y, Wu D, Hersh LB. The use of DNase I hypersensitivity site mapping to identify regulatory regions of the human cholinergic gene locus. Journal of Neurochemistry. 70: 1799-808. PMID 9572263 DOI: 10.1046/J.1471-4159.1998.70051799.X  0.304
1998 Csuhai E, Chen G, Hersh LB. Regulation of N-arginine dibasic convertase activity by amines: putative role of a novel acidic domain as an amine binding site. Biochemistry. 37: 3787-94. PMID 9521698 DOI: 10.1021/Bi971969B  0.36
1997 Sarada B, Thiele D, Dang T, Safavi A, Hersh LB, Cottam GL. Increased expression of an endopeptidase (gamma-EGE/IDE) hydrolyzing beta-endorphin during differentiation and maturation of bone marrow macrophages. Journal of Leukocyte Biology. 62: 753-60. PMID 9400816 DOI: 10.1002/Jlb.62.6.753  0.32
1997 Erbeznik H, Hersh LB. A novel mammalian high-molecular-weight aminopeptidase. Archives of Biochemistry and Biophysics. 344: 228-34. PMID 9244402 DOI: 10.1006/Abbi.1997.0210  0.318
1997 Boissière F, Hunot S, Faucheux B, Hersh LB, Agid Y, Hirsch EC. Trk neurotrophin receptors in cholinergic neurons of patients with Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 8: 1-8. PMID 8997546 DOI: 10.1159/000106594  0.309
1996 Safavi A, Miller BC, Cottam aL, Hersh LB. Identification of γ-Endorphin-Generating Enzyme as Insulin-Degrading Enzyme† Biochemistry. 35: 14318-14325. PMID 8916918 DOI: 10.1021/Bi960582Q  0.347
1996 Lian W, Wu D, Konings WN, Mierau I, Hersh LB. Heterologous expression and characterization of recombinant Lactococcus lactis neutral endopeptidase (neprilysin). Archives of Biochemistry and Biophysics. 333: 121-6. PMID 8806762 DOI: 10.1006/Abbi.1996.0372  0.375
1996 Safavi A, Miller BC, Hersh LB, Cottam GL. Purification and Characterization of a Secreted T Cell β-Endorphin Endopeptidase Advances in Experimental Medicine and Biology. 402: 71-79. PMID 8787646 DOI: 10.1007/978-1-4613-0407-4_11  0.314
1996 Wu D, Hersh LB. Identification of an active site arginine in rat choline acetyltransferase by alanine scanning mutagenesis. The Journal of Biological Chemistry. 270: 29111-6. PMID 7493935 DOI: 10.1074/Jbc.270.49.29111  0.339
1995 Inoue H, Li YP, Wagner JA, Hersh LB. Expression of the choline acetyltransferase gene depends on protein kinase A activity Journal of Neurochemistry. 64: 985-990. PMID 7861180 DOI: 10.1046/J.1471-4159.1995.64030985.X  0.309
1995 Ransmayr G, Benesch H, Nowakowski C, Künig G, Heinsen H, Riederer P, Hersh LB. Neurofibrillary tangles without cell loss in the lateral vestibular nucleus of patients with Alzheimer's disease. Neuroscience Letters. 177: 11-4. PMID 7824159 DOI: 10.1016/0304-3940(94)90032-9  0.305
1995 Safavi A, Hersh LB. Degradation of dynorphin-related peptides by the puromycin-sensitive aminopeptidase and aminopeptidase M. Journal of Neurochemistry. 65: 389-95. PMID 7790884 DOI: 10.1046/J.1471-4159.1995.65010389.X  0.308
1995 Rodd D, Hersh LB. Endopeptidase 24.16B A NEW VARIANT OF ENDOPEPTIDASE 24.16 Journal of Biological Chemistry. 270: 10056-10061. PMID 7730308 DOI: 10.1074/Jbc.270.17.10056  0.316
1995 Wu D, Ahmed SN, Lian W, Hersh LB. Activation of rat choline acetyltransferase by limited proteolysis. The Journal of Biological Chemistry. 270: 19395-401. PMID 7642620 DOI: 10.1074/Jbc.270.33.19395  0.348
1995 Constam DB, Tobler AR, Rensing-Ehl A, Kemler I, Hersh LB, Fontana A. Puromycin-sensitive aminopeptidase: Sequence analysis, expression, and functional characterization Journal of Biological Chemistry. 270: 26931-26939. PMID 7592939 DOI: 10.1074/Jbc.270.45.26931  0.311
1995 Vijayaragahaven J, Tucker M, Fehrentz JA, Isbell D, Hersh LB. Reaction of neprilysin (neutral endopeptidase) and thermolysin with cyclic peptides. Archives of Biochemistry and Biophysics. 322: 405-9. PMID 7574714 DOI: 10.1006/Abbi.1995.1481  0.312
1995 Csuhai E, Safavi A, Hersh LB. Purification and characterization of a secreted arginine-specific dibasic cleaving enzyme from EL-4 cells. Biochemistry. 34: 12411-9. PMID 7547986 DOI: 10.1021/Bi00038A039  0.338
1995 Csuhai E, Little SS, Hersh LB. Inactivation Of Neuropeptides Progress in Brain Research. 104: 131-142. DOI: 10.1016/S0079-6123(08)61788-4  0.35
1994 Quay T, Slaughter C, Davis TP, Merrill BJ, Hersh LB. Positional effects in the neprilysin (neutral endopeptidase) reaction. Archives of Biochemistry and Biophysics. 308: 133-6. PMID 8311445 DOI: 10.1006/Abbi.1994.1019  0.309
1994 Wu D, Hersh LB. Choline acetyltransferase: celebrating its fiftieth year. Journal of Neurochemistry. 62: 1653-63. PMID 8158117 DOI: 10.1046/J.1471-4159.1994.62051653.X  0.334
1994 Selden N, Geula C, Hersh L, Mesulam MM. Human striatum: chemoarchitecture of the caudate nucleus, putamen and ventral striatum in health and Alzheimer's disease. Neuroscience. 60: 621-36. PMID 7523983 DOI: 10.1016/0306-4522(94)90491-X  0.308
1994 Rodd D, Hersh L. Characterization and substrate specificity of gamma endorphin generating endopeptidase Regulatory Peptides. 53: S153-S154. DOI: 10.1016/0167-0115(94)90287-9  0.311
1993 Carbini LA, Hersh LB. Functional analysis of conserved histidines in choline acetyltransferase by site-directed mutagenesis. Journal of Neurochemistry. 61: 247-53. PMID 8515270 DOI: 10.1111/J.1471-4159.1993.Tb03561.X  0.322
1993 Wu D, Schormann N, Lian W, Deisenhofer J, Hersh LB. Expression, purification, and characterization of recombinant Drosophila choline acetyltransferase. Journal of Neurochemistry. 61: 1416-22. PMID 8376995 DOI: 10.1111/J.1471-4159.1993.Tb13635.X  0.317
1993 Li YP, Baskin F, Davis R, Hersh LB. Cholinergic neuron-specific expression of the human choline acetyltransferase gene is controlled by silencer elements. Journal of Neurochemistry. 61: 748-51. PMID 8336150 DOI: 10.1111/J.1471-4159.1993.Tb02181.X  0.324
1993 Hersh LB. Induction of choline acetyltransferase in the neuroblastoma x glioma cell line NG108-15. Neurochemical Research. 17: 1063-7. PMID 1334236 DOI: 10.1007/Bf00967282  0.324
1992 Kim YA, Shriver B, Hersh LB. Mutational analysis reveals only one catalytic histidine in neutral endopeptidase ("enkephalinase"). Biochemical and Biophysical Research Communications. 184: 883-7. PMID 1575757 DOI: 10.1016/0006-291X(92)90673-9  0.31
1992 Iijima H, Gerard NP, Squassoni C, Ewig J, Face D, Drazen JM, Kim YA, Shriver B, Hersh LB, Gerard C. Exon 16 del: a novel form of human neutral endopeptidase (CALLA). The American Journal of Physiology. 262: L725-9. PMID 1535484 DOI: 10.1152/Ajplung.1992.262.6.L725  0.323
1991 Vijayaraghavan J, Kim YA, Jackson D, Orlowski M, Hersh LB. Use of site-directed mutagenesis to identify valine-573 in the S'1 binding site of rat neutral endopeptidase 24.11 (enkephalinase). Biochemistry. 29: 8052-6. PMID 2261463 DOI: 10.1021/Bi00487A009  0.329
1991 Ibáñez CF, Pelto-Huikko M, Söder O, Ritzèn EM, Hersh LB, Hökfelt T, Persson H. Expression of choline acetyltransferase mRNA in spermatogenic cells results in an accumulation of the enzyme in the postacrosomal region of mature spermatozoa. Proceedings of the National Academy of Sciences of the United States of America. 88: 3676-80. PMID 2023918 DOI: 10.1073/Pnas.88.9.3676  0.314
1991 Lehéricy S, Hirsch EC, Hersh LB, Agid Y. Cholinergic neuronal loss in the globus pallidus of Alzheimer disease patients. Neuroscience Letters. 123: 152-5. PMID 1709266 DOI: 10.1016/0304-3940(91)90918-J  0.305
1991 Gaykema RP, Gaál G, Traber J, Hersh LB, Luiten PG. The basal forebrain cholinergic system: efferent and afferent connectivity and long-term effects of lesions. Acta Psychiatrica Scandinavica. Supplementum. 366: 14-26. PMID 1680268 DOI: 10.1111/J.1600-0447.1991.Tb03105.X  0.3
1990 Brandel JP, Hirsch EC, Hersh LB, Javoy-Agid F. Compartmental ordering of cholinergic innervation in the mediodorsal nucleus of the thalamus in human brain. Brain Research. 515: 117-25. PMID 2357550 DOI: 10.1016/0006-8993(90)90585-Y  0.31
1990 Bateman RC, Rodriguez G, Vijayaraghavan J, Hersh LB. Effect of electron withdrawing substituents on substrate hydrolysis by and inhibition of rat neutral endopeptidase 24.11 (enkephalinase) and thermolysin. Archives of Biochemistry and Biophysics. 279: 355-62. PMID 2350181 DOI: 10.1016/0003-9861(90)90502-P  0.331
1990 Carbini L, Rodriguez G, Hersh LB. Kinetic and inactivation studies of recombinant Drosophila choline acetyltransferase. Brain Research Bulletin. 24: 119-24. PMID 2310940 DOI: 10.1016/0361-9230(90)90295-B  0.334
1990 Johnson GD, Hersh LB. Studies on the subsite specificity of the rat brain puromycin-sensitive aminopeptidase Archives of Biochemistry and Biophysics. 276: 305-309. PMID 2306097 DOI: 10.1016/0003-9861(90)90724-D  0.33
1990 Dyer SH, Slaughter CA, Orth K, Moomaw CR, Hersh LB. Comparison of the soluble and membrane-bound forms of the puromycin-sensitive enkephalin-degrading aminopeptidases from rat. Journal of Neurochemistry. 54: 547-54. PMID 2299352 DOI: 10.1111/J.1471-4159.1990.Tb01906.X  0.337
1989 Shipp MA, Vijayaraghavan J, Schmidt EV, Masteller EL, D'Adamio L, Hersh LB, Reinherz EL. Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ('enkephalinase'): Direct evidence by cDNA transfection analysis Proceedings of the National Academy of Sciences of the United States of America. 86: 297-301. PMID 2521388 DOI: 10.1073/Pnas.86.1.297  0.343
1988 Mufson EJ, Mash DC, Hersh LB. Neurofibrillary tangles in cholinergic pedunculopontine neurons in Alzheimer's disease. Annals of Neurology. 24: 623-9. PMID 3202615 DOI: 10.1002/Ana.410240506  0.308
1988 McLellan S, Dyer SH, Rodriguez G, Hersh LB. Studies on the tissue distribution of the puromycin-sensitive enkephalin-degrading aminopeptidases. Journal of Neurochemistry. 51: 1552-9. PMID 3171591 DOI: 10.1111/J.1471-4159.1988.Tb01124.X  0.319
1987 Carpenter MB, Chang L, Pereira AB, Hersh LB. Comparisons of the immunocytochemical localization of choline acetyltransferase in the vestibular nuclei of the monkey and rat. Brain Research. 418: 403-8. PMID 3315111 DOI: 10.1016/0006-8993(87)90112-0  0.305
1987 Tago H, McGeer PL, Bruce G, Hersh LB. Distribution of choline acetyltransferase-containing neurons of the hypothalamus. Brain Research. 415: 49-62. PMID 3304532 DOI: 10.1016/0006-8993(87)90268-X  0.31
1987 Hersh LB, Aboukhair N, Watson S. Immunohistochemical localization of aminopeptidase M in rat brain and periphery: relationship of enzyme localization and enkephalin metabolism. Peptides. 8: 523-32. PMID 2889201 DOI: 10.1016/0196-9781(87)90019-2  0.317
1986 Hersh LB. Nomenclature for enkephalin degrading peptidases. Life Sciences. 38: 1151-3. PMID 3515092 DOI: 10.1016/0024-3205(86)90168-2  0.305
1986 Ulrich C, Hersh LB. Degradation of alpha and beta neo-endorphin by rat brain membrane peptidases. Peptides. 6: 475-82. PMID 2999726 DOI: 10.1016/0196-9781(85)90113-5  0.348
1986 Armstrong DM, Bruce G, Hersh LB, Terry RD. Choline acetyltransferase immunoreactivity in neuritic plaques of Alzheimer brain. Neuroscience Letters. 71: 229-34. PMID 2431362 DOI: 10.1016/0304-3940(86)90564-1  0.32
1985 Bruce G, Wainer BH, Hersh LB. Immunoaffinity purification of human choline acetyltransferase: comparison of the brain and placental enzymes. Journal of Neurochemistry. 45: 611-20. PMID 4009177 DOI: 10.1111/J.1471-4159.1985.Tb04030.X  0.332
1985 German DC, Bruce G, Hersh LB. Immunohistochemical staining of cholinergic neurons in the human brain using a polyclonal antibody to human choline acetyltransferase. Neuroscience Letters. 61: 1-5. PMID 3908999 DOI: 10.1016/0304-3940(85)90391-X  0.307
1985 Hersh LB. Characterization of membrane-bound aminopeptidases from rat brain: identification of the enkephalin-degrading aminopeptidase. Journal of Neurochemistry. 44: 1427-35. PMID 3886843 DOI: 10.1111/J.1471-4159.1985.Tb08779.X  0.34
1984 Hersh LB. Reaction of opioid peptides with neutral endopeptidase ("enkephalinase"). Journal of Neurochemistry. 43: 487-93. PMID 6376710 DOI: 10.1111/J.1471-4159.1984.Tb00925.X  0.342
1984 Rush RS, Mitas M, Powers JC, Tanaka T, Hersh LB. Fluorogenic substrates for the enkephalin-degrading neutral endopeptidase (Enkephalinase). Archives of Biochemistry and Biophysics. 231: 390-9. PMID 6375573 DOI: 10.1016/0003-9861(84)90402-8  0.344
1983 Gafford JT, Skidgel RA, Erdös EG, Hersh LB. Human kidney "enkephalinase", a neutral metalloendopeptidase that cleaves active peptides. Biochemistry. 22: 3265-71. PMID 6349683 DOI: 10.1021/Bi00282A035  0.355
1983 Hersh LB, Gafford JT, Powers JC, Tanaka T, Erdös EG. Novel substrates for angiotensin I converting enzyme. Biochemical and Biophysical Research Communications. 110: 654-9. PMID 6301459 DOI: 10.1016/0006-291X(83)91199-3  0.333
1981 Hersh LB. Solubilization and characterization of two rat brain membrane-bound aminopeptidases active on Met-enkephalin. Biochemistry. 20: 2345-50. PMID 7236606 DOI: 10.1021/Bi00511A042  0.316
1981 Hersh LB. Immunological, physical, and chemical evidence for the identity of brain and kidney post-proline cleaving-enzyme. Journal of Neurochemistry. 37: 172-8. PMID 7019392 DOI: 10.1111/J.1471-4159.1981.Tb05305.X  0.347
1981 Hersh LB, McKelvy JF. An aminopeptidase from bovine brain which catalyzes the hydrolysis of enkephalin. Journal of Neurochemistry. 36: 171-8. PMID 6780659 DOI: 10.1111/J.1471-4159.1981.Tb02392.X  0.339
1980 Hersh LB, Smith TE, McKelvy JF. Cleavage of endorphins to des-Tyr endorphins by homogeneous bovine brain aminopeptidase. Nature. 286: 160-162. PMID 7402309 DOI: 10.1038/286160A0  0.331
1980 Hersh LB. Studies on the kinetic mechanism and salt activation of bovine brain choline acetyltransferase. Journal of Neurochemistry. 34: 1077-81. PMID 7373298 DOI: 10.1111/J.1471-4159.1980.Tb09942.X  0.338
1980 Blumberg S, Teichberg VI, Charli JL, Hersh LB, McKelvy JF. Cleavage of substance P to an N-terminal tetrapeptide and a C-terminal heptapeptide by a post-proline Cleaving enzyme from bovine brain. Brain Research. 192: 477-86. PMID 6155176 DOI: 10.1016/0006-8993(80)90898-7  0.347
1979 Hersh LB, McKelvy JF. Enzymes involved in the degradation of thyrotropin releasing hormone (TRH) and luteinizing hormone releasing hormone (LH-RH) in bovine brain. Brain Research. 168: 553-64. PMID 107998 DOI: 10.1016/0006-8993(79)90309-3  0.302
1978 Hersh LB, Coe B, Casey L. A fluorometric assay for choline acetyltransferase and its use in the purification of the enzyme from human placenta. Journal of Neurochemistry. 30: 1077-85. PMID 660185 DOI: 10.1111/J.1471-4159.1978.Tb12401.X  0.318
1973 Bellion E, Hersh LB. Methylamine metabolism in a pseudomonas species. Archives of Biochemistry and Biophysics. 153: 368-74. PMID 4650618 DOI: 10.1016/0003-9861(72)90457-2  0.306
1969 Hersh LB, Jencks WP. [15] 3-ketoacid CoA-transferase: [EC 2.8.3.5 Succinyl-CoA: 3-oxoacid CoA-transferase] Methods in Enzymology. 13: 75-81. DOI: 10.1016/0076-6879(69)13019-0  0.303
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