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David Botstein - Publications

Affiliations: 
1967-1987 Massachusetts Institute of Technology, Cambridge, MA, United States 
 1987-1990 Genentech, Inc., San Francisco, CA, United States 
 1990-2003 Stanford University, Palo Alto, CA 
 2003- Princeton University, Princeton, NJ 
 2013- Calico Life Sciences, LLC 
Area:
Genomics
Website:
http://molbio.princeton.edu/faculty/molbio-faculty/96-botstein
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323 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Arita Y, Kim G, Li Z, Friesen H, Turco G, Wang RY, Climie D, Usaj M, Hotz M, Stoops EH, Baryshnikova A, Boone C, Botstein D, Andrews BJ, McIsaac RS. A genome-scale yeast library with inducible expression of individual genes. Molecular Systems Biology. 17: e10207. PMID 34096681 DOI: 10.15252/msb.202110207  0.598
2020 Soifer I, Fong NL, Yi N, Ireland AT, Lam I, Sooknah M, Paw JS, Peluso P, Concepcion GT, Rank D, Hastie AR, Jojic V, Ruby JG, Botstein D, Roy MA. Fully Phased Sequence of a Diploid Human Genome Determined from the DNA of a Single Individual. G3 (Bethesda, Md.). PMID 32631951 DOI: 10.1534/G3.119.400995  0.336
2020 Gibney PA, Chen A, Schieler A, Chen JC, Xu Y, Hendrickson DG, McIsaac RS, Rabinowitz JD, Botstein D. A tps1Δ persister-like state in Saccharomyces cerevisiae is regulated by MKT1. Plos One. 15: e0233779. PMID 32470059 DOI: 10.1371/Journal.Pone.0233779  0.333
2019 Bradley PH, Gibney PA, Botstein D, Troyanskaya OG, Rabinowitz JD. Minor Isozymes Tailor Yeast Metabolism to Carbon Availability. Msystems. 4. PMID 30834327 DOI: 10.1128/mSystems.00170-18  0.809
2018 Hendrickson DG, Soifer I, Wranik BJ, Botstein D, Scott McIsaac R. Simultaneous Profiling of DNA Accessibility and Gene Expression Dynamics with ATAC-Seq and RNA-Seq. Methods in Molecular Biology (Clifton, N.J.). 1819: 317-333. PMID 30421411 DOI: 10.1007/978-1-4939-8618-7_15  0.403
2018 Gibney PA, Schieler A, Chen JC, Bacha-Hummel JM, Botstein M, Volpe M, Silverman SJ, Xu Y, Bennett BD, Rabinowitz JD, Botstein D. Common and Divergent Features of Galactose-1-phosphate and Fructose-1-phosphate Toxicity in Yeast. Molecular Biology of the Cell. PMID 29444955 DOI: 10.1091/Mbc.E17-11-0666  0.325
2016 Møller HD, Bojsen RK, Tachibana C, Parsons L, Botstein D, Regenberg B. Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells. Journal of Visualized Experiments : Jove. PMID 27077531 DOI: 10.3791/54239  0.375
2015 Reavey CT, Hickman MJ, Dobi KC, Botstein D, Winston F. Analysis of Polygenic Mutants Suggests a Role for Mediator in Regulating Transcriptional Activation Distance in Saccharomyces cerevisiae. Genetics. 201: 599-612. PMID 26281848 DOI: 10.1534/Genetics.115.181164  0.795
2015 Møller HD, Parsons L, Jørgensen TS, Botstein D, Regenberg B. Extrachromosomal circular DNA is common in yeast. Proceedings of the National Academy of Sciences of the United States of America. 112: E3114-22. PMID 26038577 DOI: 10.1073/Pnas.1508825112  0.427
2014 Botstein D. Lasker∼Koshland to genetics pioneer. Cell. 158: 1230-2. PMID 25215481 DOI: 10.1016/J.Cell.2014.08.020  0.31
2014 McIsaac RS, Gibney PA, Chandran SS, Benjamin KR, Botstein D. Synthetic biology tools for programming gene expression without nutritional perturbations in Saccharomyces cerevisiae. Nucleic Acids Research. 42: e48. PMID 24445804 DOI: 10.1093/Nar/Gkt1402  0.78
2013 McIsaac RS, Oakes BL, Botstein D, Noyes MB. Rapid synthesis and screening of chemically activated transcription factors with GFP-based reporters. Journal of Visualized Experiments : Jove. e51153. PMID 24300440 DOI: 10.3791/51153  0.775
2013 Gibney PA, Lu C, Caudy AA, Hess DC, Botstein D. Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes. Proceedings of the National Academy of Sciences of the United States of America. 110: E4393-402. PMID 24167267 DOI: 10.1073/Pnas.1318100110  0.715
2013 Lang GI, Rice DP, Hickman MJ, Sodergren E, Weinstock GM, Botstein D, Desai MM. Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations. Nature. 500: 571-4. PMID 23873039 DOI: 10.1038/Nature12344  0.744
2013 Caudy AA, Guan Y, Jia Y, Hansen C, DeSevo C, Hayes AP, Agee J, Alvarez-Dominguez JR, Arellano H, Barrett D, Bauerle C, Bisaria N, Bradley PH, Breunig JS, Bush E, ... ... Botstein D, et al. A new system for comparative functional genomics of Saccharomyces yeasts. Genetics. 195: 275-87. PMID 23852385 DOI: 10.1534/Genetics.113.152918  0.816
2013 McIsaac RS, Silverman SJ, Parsons L, Xu P, Briehof R, McClean MN, Botstein D. Visualization and analysis of mRNA molecules using fluorescence in situ hybridization in Saccharomyces cerevisiae. Journal of Visualized Experiments : Jove. e50382. PMID 23793137 DOI: 10.3791/50382  0.736
2013 Gibney PA, Hickman MJ, Bradley PH, Matese JC, Botstein D. Phylogenetic portrait of the Saccharomyces cerevisiae functional genome. G3 (Bethesda, Md.). 3: 1335-40. PMID 23749449 DOI: 10.1534/G3.113.006585  0.829
2013 Reisser C, Dick C, Kruglyak L, Botstein D, Schacherer J, Hess D. Genetic Basis of Ammonium Toxicity Resistance in a Sake Strain of Yeast: A Mendelian Case. G3 (Bethesda, Md.). PMID 23550140 DOI: 10.1534/G3.113.005884  0.551
2013 Dolinski K, Botstein D. Automating the construction of gene ontologies. Nature Biotechnology. 31: 34-5. PMID 23302932 DOI: 10.1038/Nbt.2476  0.401
2013 McIsaac RS, Oakes BL, Wang X, Dummit KA, Botstein D, Noyes MB. Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast. Nucleic Acids Research. 41: e57. PMID 23275543 DOI: 10.1093/Nar/Gks1313  0.786
2013 Welch AZ, Gibney PA, Botstein D, Koshland DE. TOR and RAS pathways regulate desiccation tolerance in Saccharomyces cerevisiae. Molecular Biology of the Cell. 24: 115-28. PMID 23171550 DOI: 10.1091/Mbc.E12-07-0524  0.778
2013 Slavov N, Botstein D. Decoupling nutrient signaling from growth rate causes aerobic glycolysis and deregulation of cell size and gene expression. Molecular Biology of the Cell. 24: 157-68. PMID 23135997 DOI: 10.1091/Mbc.E12-09-0670  0.687
2012 Doherty KM, Pride LD, Lukose J, Snydsman BE, Charles R, Pramanik A, Muller EG, Botstein D, Moore CW. Loss of a 20S proteasome activator in Saccharomyces cerevisiae downregulates genes important for genomic integrity, increases DNA damage, and selectively sensitizes cells to agents with diverse mechanisms of action. G3 (Bethesda, Md.). 2: 943-59. PMID 22908043 DOI: 10.1534/G3.112.003376  0.392
2012 McIsaac RS, Petti AA, Bussemaker HJ, Botstein D. Perturbation-based analysis and modeling of combinatorial regulation in the yeast sulfur assimilation pathway. Molecular Biology of the Cell. 23: 2993-3007. PMID 22696683 DOI: 10.1091/Mbc.E12-03-0232  0.79
2012 Petti AA, McIsaac RS, Ho-Shing O, Bussemaker HJ, Botstein D. Combinatorial control of diverse metabolic and physiological functions by transcriptional regulators of the yeast sulfur assimilation pathway. Molecular Biology of the Cell. 23: 3008-24. PMID 22696679 DOI: 10.1091/Mbc.E12-03-0233  0.786
2012 Slavov N, Airoldi EM, van Oudenaarden A, Botstein D. A conserved cell growth cycle can account for the environmental stress responses of divergent eukaryotes. Molecular Biology of the Cell. 23: 1986-97. PMID 22456505 DOI: 10.1091/Mbc.E11-11-0961  0.658
2011 Botstein D, Fink GR. Yeast: an experimental organism for 21st Century biology. Genetics. 189: 695-704. PMID 22084421 DOI: 10.1534/Genetics.111.130765  0.537
2011 Slavov N, Macinskas J, Caudy A, Botstein D. Metabolic cycling without cell division cycling in respiring yeast. Proceedings of the National Academy of Sciences of the United States of America. 108: 19090-5. PMID 22065748 DOI: 10.1073/Pnas.1116998108  0.668
2011 Lang GI, Botstein D. A test of the coordinated expression hypothesis for the origin and maintenance of the GAL cluster in yeast. Plos One. 6: e25290. PMID 21966486 DOI: 10.1371/Journal.Pone.0025290  0.739
2011 McIsaac RS, Silverman SJ, McClean MN, Gibney PA, Macinskas J, Hickman MJ, Petti AA, Botstein D. Fast-acting and nearly gratuitous induction of gene expression and protein depletion in Saccharomyces cerevisiae. Molecular Biology of the Cell. 22: 4447-59. PMID 21965290 DOI: 10.1091/Mbc.E11-05-0466  0.794
2011 Hickman MJ, Petti AA, Ho-Shing O, Silverman SJ, McIsaac RS, Lee TA, Botstein D. Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast. Molecular Biology of the Cell. 22: 4192-204. PMID 21900497 DOI: 10.1091/Mbc.E11-05-0467  0.785
2011 Petti AA, Crutchfield CA, Rabinowitz JD, Botstein D. Survival of starving yeast is correlated with oxidative stress response and nonrespiratory mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America. 108: E1089-98. PMID 21734149 DOI: 10.1073/Pnas.1101494108  0.395
2011 Lang GI, Botstein D, Desai MM. Genetic variation and the fate of beneficial mutations in asexual populations. Genetics. 188: 647-61. PMID 21546542 DOI: 10.1534/Genetics.111.128942  0.691
2011 Slavov N, Botstein D. Coupling among growth rate response, metabolic cycle, and cell division cycle in yeast. Molecular Biology of the Cell. 22: 1997-2009. PMID 21525243 DOI: 10.1091/Mbc.E11-02-0132  0.678
2011 Botstein D. Genome-sequencing anniversary. Fruits of genome sequences for biology. Science (New York, N.Y.). 331: 1025. PMID 21350164 DOI: 10.1126/Science.1204038  0.365
2011 Gresham D, Boer VM, Caudy A, Ziv N, Brandt NJ, Storey JD, Botstein D. System-level analysis of genes and functions affecting survival during nutrient starvation in Saccharomyces cerevisiae. Genetics. 187: 299-317. PMID 20944018 DOI: 10.1534/Genetics.110.120766  0.353
2011 Silverman SJ, Petti AA, Slavov N, Parsons L, Briehof R, Thiberge SY, Zenklusen D, Gandhi SJ, Larson DR, Singer RH, Botstein D. Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, (6946-6951) 10.1073/pnas.1002422107) Proceedings of the National Academy of Sciences of the United States of America. 108: 12185. DOI: 10.1073/Pnas.1109536108  0.607
2010 Wyart M, Botstein D, Wingreen NS. Evaluating gene expression dynamics using pairwise RNA FISH data. Plos Computational Biology. 6: e1000979. PMID 21079668 DOI: 10.1371/Journal.Pcbi.1000979  0.383
2010 Botstein D. Technological innovation leads to fundamental understanding in cell biology. Molecular Biology of the Cell. 21: 3791-2. PMID 21079013 DOI: 10.1091/Mbc.E10-04-0366  0.304
2010 Gresham D, Usaite R, Germann SM, Lisby M, Botstein D, Regenberg B. Adaptation to diverse nitrogen-limited environments by deletion or extrachromosomal element formation of the GAP1 locus. Proceedings of the National Academy of Sciences of the United States of America. 107: 18551-6. PMID 20937885 DOI: 10.1073/Pnas.1014023107  0.355
2010 Silverman SJ, Petti AA, Slavov N, Parsons L, Briehof R, Thiberge SY, Zenklusen D, Gandhi SJ, Larson DR, Singer RH, Botstein D. Metabolic cycling in single yeast cells from unsynchronized steady-state populations limited on glucose or phosphate. Proceedings of the National Academy of Sciences of the United States of America. 107: 6946-51. PMID 20335538 DOI: 10.1073/Pnas.1002422107  0.675
2010 Gresham D, Curry B, Ward A, Gordon DB, Brizuela L, Kruglyak L, Botstein D. Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes. Proceedings of the National Academy of Sciences of the United States of America. 107: 1482-7. PMID 20080586 DOI: 10.1073/Pnas.0913883107  0.33
2010 Botstein D. It's the data! Molecular Biology of the Cell. 21: 4-6. PMID 20048255 DOI: 10.1091/Mbc.E09-07-0575  0.359
2010 Engel SR, Balakrishnan R, Binkley G, Christie KR, Costanzo MC, Dwight SS, Fisk DG, Hirschman JE, Hitz BC, Hong EL, Krieger CJ, Livstone MS, Miyasato SR, Nash R, Oughtred R, ... ... Botstein D, et al. Saccharomyces Genome Database provides mutant phenotype data. Nucleic Acids Research. 38: D433-6. PMID 19906697 DOI: 10.1093/Nar/Gkp917  0.351
2010 Boer VM, Crutchfield CA, Bradley PH, Botstein D, Rabinowitz JD. Growth-limiting intracellular metabolites in yeast growing under diverse nutrient limitations. Molecular Biology of the Cell. 21: 198-211. PMID 19889834 DOI: 10.1091/Mbc.E09-07-0597  0.776
2009 Ho CH, Magtanong L, Barker SL, Gresham D, Nishimura S, Natarajan P, Koh JL, Porter J, Gray CA, Andersen RJ, Giaever G, Nislow C, Andrews B, Botstein D, Graham TR, et al. A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nature Biotechnology. 27: 369-77. PMID 19349972 DOI: 10.1038/Nbt.1534  0.592
2009 Lang GI, Murray AW, Botstein D. The cost of gene expression underlies a fitness trade-off in yeast. Proceedings of the National Academy of Sciences of the United States of America. 106: 5755-60. PMID 19299502 DOI: 10.1073/Pnas.0901620106  0.767
2009 Airoldi EM, Huttenhower C, Gresham D, Lu C, Caudy AA, Dunham MJ, Broach JR, Botstein D, Troyanskaya OG. Predicting cellular growth from gene expression signatures. Plos Computational Biology. 5: e1000257. PMID 19119411 DOI: 10.1371/Journal.Pcbi.1000257  0.805
2009 Lu C, Brauer MJ, Botstein D. Slow growth induces heat-shock resistance in normal and respiratory-deficient yeast. Molecular Biology of the Cell. 20: 891-903. PMID 19056679 DOI: 10.1091/Mbc.E08-08-0852  0.567
2009 Livstone MS, Oughtred R, Heinicke S, Kang F, Vernot B, Goldman A, Durand D, Botstein D, Dolinski K. P-POD, The Princeton Protein Orthology Database, as a Tool for Identifying Gene Function Nature Precedings. DOI: 10.1038/Npre.2009.3119.1  0.371
2008 Gresham D, Desai MM, Tucker CM, Jenq HT, Pai DA, Ward A, DeSevo CG, Botstein D, Dunham MJ. The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast. Plos Genetics. 4: e1000303. PMID 19079573 DOI: 10.1371/Journal.Pgen.1000303  0.632
2008 Boer VM, Amini S, Botstein D. Influence of genotype and nutrition on survival and metabolism of starving yeast. Proceedings of the National Academy of Sciences of the United States of America. 105: 6930-5. PMID 18456835 DOI: 10.1073/Pnas.0802601105  0.332
2008 Gresham D, Dunham MJ, Botstein D. Comparing whole genomes using DNA microarrays. Nature Reviews. Genetics. 9: 291-302. PMID 18347592 DOI: 10.1038/Nrg2335  0.615
2008 Harris MA, Deegan JI, Ireland A, Lomax J, Ashburner M, Tweedie S, Carbon S, Lewis S, Mungall C, Day-Richter J, Eilbeck K, Blake JA, Bult C, Diehl AD, Dolan M, ... ... Botstein D, et al. The Gene Ontology project in 2008 Nucleic Acids Research. 36. PMID 17984083 DOI: 10.1093/Nar/Gkm883  0.408
2008 Hong EL, Balakrishnan R, Dong Q, Christie KR, Park J, Binkley G, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hirschman JE, Hitz BC, Krieger CJ, Livstone MS, Miyasato SR, ... ... Botstein D, et al. Gene Ontology annotations at SGD: new data sources and annotation methods. Nucleic Acids Research. 36: D577-81. PMID 17982175 DOI: 10.1093/Nar/Gkm909  0.388
2008 Brauer MJ, Huttenhower C, Airoldi EM, Rosenstein R, Matese JC, Gresham D, Boer VM, Troyanskaya OG, Botstein D. Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast. Molecular Biology of the Cell. 19: 352-67. PMID 17959824 DOI: 10.1091/Mbc.E07-08-0779  0.698
2007 Heinicke S, Livstone MS, Lu C, Oughtred R, Kang F, Angiuoli SV, White O, Botstein D, Dolinski K. The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. Plos One. 2: e766. PMID 17712414 DOI: 10.1371/Journal.Pone.0000766  0.551
2007 Schacherer J, Ruderfer DM, Gresham D, Dolinski K, Botstein D, Kruglyak L. Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains. Plos One. 2: e322. PMID 17389913 DOI: 10.1371/Journal.Pone.0000322  0.309
2006 Pelham RJ, Rodgers L, Hall I, Lucito R, Nguyen KC, Navin N, Hicks J, Mu D, Powers S, Wigler M, Botstein D. Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 103: 19848-53. PMID 17167050 DOI: 10.1073/Pnas.0609635104  0.303
2006 Sørlie T, Perou CM, Fan C, Geisler S, Aas T, Nobel A, Anker G, Akslen LA, Botstein D, Børresen-Dale AL, Lønning PE. Gene expression profiles do not consistently predict the clinical treatment response in locally advanced breast cancer. Molecular Cancer Therapeutics. 5: 2914-8. PMID 17121939 DOI: 10.1158/1535-7163.Mct-06-0126  0.326
2006 Hess DC, Lu W, Rabinowitz JD, Botstein D. Ammonium toxicity and potassium limitation in yeast. Plos Biology. 4: e351. PMID 17048990 DOI: 10.1371/Journal.Pbio.0040351  0.551
2006 Fisk DG, Ball CA, Dolinski K, Engel SR, Hong EL, Issel-Tarver L, Schwartz K, Sethuraman A, Botstein D, Cherry JM. Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Yeast (Chichester, England). 23: 857-65. PMID 17001629 DOI: 10.1002/Yea.1400  0.311
2006 Heck JA, Gresham D, Botstein D, Alani E. Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements. Genetics. 174: 519-23. PMID 16816424 DOI: 10.1534/Genetics.106.059311  0.617
2006 Reguly T, Breitkreutz A, Boucher L, Breitkreutz BJ, Hon GC, Myers CL, Parsons A, Friesen H, Oughtred R, Tong A, Stark C, Ho Y, Botstein D, Andrews B, Boone C, et al. Comprehensive curation and analysis of global interaction networks in Saccharomyces cerevisiae. Journal of Biology. 5: 11. PMID 16762047 DOI: 10.1186/Jbiol36  0.782
2006 Gresham D, Ruderfer DM, Pratt SC, Schacherer J, Dunham MJ, Botstein D, Kruglyak L. Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray. Science (New York, N.Y.). 311: 1932-6. PMID 16527929 DOI: 10.1126/Science.1123726  0.621
2006 Diehn M, Bhattacharya R, Botstein D, Brown PO. Genome-scale identification of membrane-associated human mRNAs. Plos Genetics. 2: e11. PMID 16415983 DOI: 10.1371/Journal.Pgen.0020011  0.551
2006 Hirschman JE, Balakrishnan R, Christie KR, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hong EL, Livstone MS, Nash R, Park J, Oughtred R, Skrzypek M, Starr B, Theesfeld CL, ... ... Botstein D, et al. Genome Snapshot: a new resource at the Saccharomyces Genome Database (SGD) presenting an overview of the Saccharomyces cerevisiae genome. Nucleic Acids Research. 34: D442-5. PMID 16381907 DOI: 10.1093/Nar/Gkj117  0.387
2006 Ronen M, Botstein D. Transcriptional response of steady-state yeast cultures to transient perturbations in carbon source. Proceedings of the National Academy of Sciences of the United States of America. 103: 389-94. PMID 16381818 DOI: 10.1073/Pnas.0509978103  0.395
2005 Dolinski K, Botstein D. Changing perspectives in yeast research nearly a decade after the genome sequence. Genome Research. 15: 1611-9. PMID 16339358 DOI: 10.1101/087969807.46.19  0.351
2005 Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, Lamborn KR, Berger MS, Botstein D, Brown PO, Israel MA. Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme. Proceedings of the National Academy of Sciences of the United States of America. 102: 5814-9. PMID 15827123 DOI: 10.1073/Pnas.0402870102  0.56
2005 Shyamsundar R, Kim YH, Higgins JP, Montgomery K, Jorden M, Sethuraman A, van de Rijn M, Botstein D, Brown PO, Pollack JR. A DNA microarray survey of gene expression in normal human tissues. Genome Biology. 6: R22. PMID 15774023 DOI: 10.1186/Gb-2005-6-3-R22  0.586
2005 Brauer MJ, Saldanha AJ, Dolinski K, Botstein D. Homeostatic adjustment and metabolic remodeling in glucose-limited yeast cultures. Molecular Biology of the Cell. 16: 2503-17. PMID 15758028 DOI: 10.1091/Mbc.E04-11-0968  0.778
2005 Wang W, Cherry JM, Nochomovitz Y, Jolly E, Botstein D, Li H. Inference of combinatorial regulation in yeast transcriptional networks: a case study of sporulation. Proceedings of the National Academy of Sciences of the United States of America. 102: 1998-2003. PMID 15684073 DOI: 10.1073/Pnas.0405537102  0.781
2005 Balakrishnan R, Christie KR, Costanzo MC, Dolinski K, Dwight SS, Engel SR, Fisk DG, Hirschman JE, Hong EL, Nash R, Oughtred R, Skrzypek M, Theesfeld CL, Binkley G, Dong Q, ... ... Botstein D, et al. Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Nucleic Acids Research. 33: D374-7. PMID 15608219 DOI: 10.1093/Nar/Gki023  0.34
2005 Shyamsundar R, Kim YH, Higgins JP, Montgomery K, Jorden M, Sethuraman A, van de Rijn M, Botstein D, Brown PO, Pollack JR. Genome Biology. 6: 404. DOI: 10.1186/Gb-2005-6-9-404  0.511
2005 Diehn M, Bhattacharya R, Botstein D, Brown P. Genome-scale Identification of Secreted and Membrane-associated Tumor Markers International Journal of Radiation Oncology*Biology*Physics. 63: S458. DOI: 10.1016/J.Ijrobp.2005.07.780  0.455
2004 Rees CA, Demeter J, Matese JC, Botstein D, Sherlock G. GeneXplorer: an interactive web application for microarray data visualization and analysis. Bmc Bioinformatics. 5: 141. PMID 15458579 DOI: 10.1186/1471-2105-5-141  0.594
2004 Shapira M, Segal E, Botstein D. Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress. Molecular Biology of the Cell. 15: 5659-69. PMID 15371544 DOI: 10.1091/Mbc.E04-04-0340  0.314
2004 Tu IP, Schaner M, Diehn M, Sikic BI, Brown PO, Botstein D, Fero MJ. A method for detecting and correcting feature misidentification on expression microarrays. Bmc Genomics. 5: 64. PMID 15357875 DOI: 10.1186/1471-2164-5-64  0.505
2004 Boyle EI, Weng S, Gollub J, Jin H, Botstein D, Cherry JM, Sherlock G. GO::TermFinder--open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes. Bioinformatics (Oxford, England). 20: 3710-5. PMID 15297299 DOI: 10.1093/Bioinformatics/Bth456  0.626
2004 Saldanha AJ, Brauer MJ, Botstein D. Nutritional homeostasis in batch and steady-state culture of yeast. Molecular Biology of the Cell. 15: 4089-104. PMID 15240820 DOI: 10.1091/Mbc.E04-04-0306  0.79
2004 Dwight SS, Balakrishnan R, Christie KR, Costanzo MC, Dolinski K, Engel SR, Feierbach B, Fisk DG, Hirschman J, Hong EL, Issel-Tarver L, Nash RS, Sethuraman A, Starr B, Theesfeld CL, ... ... Botstein D, et al. Saccharomyces genome database: underlying principles and organisation. Briefings in Bioinformatics. 5: 9-22. PMID 15153302 DOI: 10.1093/Bib/5.1.9  0.325
2004 Lossos IS, Czerwinski DK, Alizadeh AA, Wechser MA, Tibshirani R, Botstein D, Levy R. Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. The New England Journal of Medicine. 350: 1828-37. PMID 15115829 DOI: 10.1056/Nejmoa032520  0.385
2004 Novoradovskaya N, Whitfield ML, Basehore LS, Novoradovsky A, Pesich R, Usary J, Karaca M, Wong WK, Aprelikova O, Fero M, Perou CM, Botstein D, Braman J. Universal Reference RNA as a standard for microarray experiments. Bmc Genomics. 5: 20. PMID 15113400 DOI: 10.1186/1471-2164-5-20  0.332
2004 Zhao H, Langerød A, Ji Y, Nowels KW, Nesland JM, Tibshirani R, Bukholm IK, Kåresen R, Botstein D, Børresen-Dale AL, Jeffrey SS. Different gene expression patterns in invasive lobular and ductal carcinomas of the breast. Molecular Biology of the Cell. 15: 2523-36. PMID 15034139 DOI: 10.1091/Mbc.E03-11-0786  0.424
2004 Murray JI, Whitfield ML, Trinklein ND, Myers RM, Brown PO, Botstein D. Diverse and specific gene expression responses to stresses in cultured human cells. Molecular Biology of the Cell. 15: 2361-74. PMID 15004229 DOI: 10.1091/Mbc.E03-11-0799  0.662
2004 Chang HY, Sneddon JB, Alizadeh AA, Sood R, West RB, Montgomery K, Chi JT, van de Rijn M, Botstein D, Brown PO. Gene expression signature of fibroblast serum response predicts human cancer progression: similarities between tumors and wounds. Plos Biology. 2: E7. PMID 14737219 DOI: 10.1371/Journal.Pbio.0020007  0.523
2004 Lapointe J, Li C, Higgins JP, van de Rijn M, Bair E, Montgomery K, Ferrari M, Egevad L, Rayford W, Bergerheim U, Ekman P, DeMarzo AM, Tibshirani R, Botstein D, Brown PO, et al. Gene expression profiling identifies clinically relevant subtypes of prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 101: 811-6. PMID 14711987 DOI: 10.1073/Pnas.0304146101  0.498
2004 Christie KR, Weng S, Balakrishnan R, Costanzo MC, Dolinski K, Dwight SS, Engel SR, Feierbach B, Fisk DG, Hirschman JE, Hong EL, Issel-Tarver L, Nash R, Sethuraman A, Starr B, ... ... Botstein D, et al. Saccharomyces Genome Database (SGD) provides tools to identify and analyze sequences from Saccharomyces cerevisiae and related sequences from other organisms. Nucleic Acids Research. 32: D311-4. PMID 14681421 DOI: 10.1093/Nar/Gkh033  0.392
2004 Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, Richter J, Rubin GM, Blake JA, Bult C, Dolan M, ... ... Botstein D, et al. The Gene Ontology (GO) database and informatics resource. Nucleic Acids Research. 32: D258-61. PMID 14681407 DOI: 10.1093/nar/gkh036  0.521
2004 Shakoury-Elizeh M, Tiedeman J, Rashford J, Ferea T, Demeter J, Garcia E, Rolfes R, Brown PO, Botstein D, Philpott CC. Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae. Molecular Biology of the Cell. 15: 1233-43. PMID 14668481 DOI: 10.1091/Mbc.E03-09-0642  0.464
2004 Trinklein ND, Murray JI, Hartman SJ, Botstein D, Myers RM. The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response. Molecular Biology of the Cell. 15: 1254-61. PMID 14668476 DOI: 10.1091/Mbc.E03-10-0738  0.559
2004 Zhao H, Whitfield ML, Xu T, Botstein D, Brooks JD. Diverse effects of methylseleninic acid on the transcriptional program of human prostate cancer cells. Molecular Biology of the Cell. 15: 506-19. PMID 14617803 DOI: 10.1091/Mbc.E03-07-0501  0.354
2004 Alter O, Golub GH, Brown PO, Botstein D. Integrative data-driven mathematical models predict novel genome-scale correlation between DNA replication initiation and RNA transcription during the cell cycle in yeast Aiche Annual Meeting, Conference Proceedings. 1007-1008.  0.792
2004 Alter O, Golub GH, Brown PO, Botstein D. Integrative data-driven mathematical models predict novel genomescale correlation between DNA replication initiation and RNA transcription during the cell cycle in yeast Aiche Annual Meeting, Conference Proceedings. 8303-8304.  0.786
2004 Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, Richter J, Rubin GM, Blake JA, Bult C, Dolan M, ... ... Botstein D, et al. The Gene Oncology (GO) database and informatics resource Nucleic Acids Research. 32: D258-D261.  0.517
2003 Linn SC, West RB, Pollack JR, Zhu S, Hernandez-Boussard T, Nielsen TO, Rubin BP, Patel R, Goldblum JR, Siegmund D, Botstein D, Brown PO, Gilks CB, van de Rijn M. Gene expression patterns and gene copy number changes in dermatofibrosarcoma protuberans. The American Journal of Pathology. 163: 2383-95. PMID 14633610 DOI: 10.1016/S0002-9440(10)63593-6  0.585
2003 Roose JP, Diehn M, Tomlinson MG, Lin J, Alizadeh AA, Botstein D, Brown PO, Weiss A. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. Plos Biology. 1: E53. PMID 14624253 DOI: 10.1371/Journal.Pbio.0000053  0.514
2003 Smith KS, Chanda SK, Lingbeek M, Ross DT, Botstein D, van Lohuizen M, Cleary ML. Bmi-1 regulation of INK4A-ARF is a downstream requirement for transformation of hematopoietic progenitors by E2a-Pbx1. Molecular Cell. 12: 393-400. PMID 14536079 DOI: 10.1016/S1097-2765(03)00277-6  0.339
2003 Whitfield ML, Finlay DR, Murray JI, Troyanskaya OG, Chi JT, Pergamenschikov A, McCalmont TH, Brown PO, Botstein D, Connolly MK. Systemic and cell type-specific gene expression patterns in scleroderma skin. Proceedings of the National Academy of Sciences of the United States of America. 100: 12319-24. PMID 14530402 DOI: 10.1073/Pnas.1635114100  0.753
2003 Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PH, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. The American Journal of Pathology. 163: 1449-56. PMID 14507652 DOI: 10.1016/S0002-9440(10)63502-X  0.494
2003 Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn M, Botstein D, Brown PO. Endothelial cell diversity revealed by global expression profiling. Proceedings of the National Academy of Sciences of the United States of America. 100: 10623-8. PMID 12963823 DOI: 10.1073/Pnas.1434429100  0.674
2003 Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, Wang YC, Duran GE, Sikic TL, Caldeira S, Skomedal H, Tu IP, Hernandez-Boussard T, Johnson SW, O'Dwyer PJ, ... ... Botstein D, et al. Gene expression patterns in ovarian carcinomas. Molecular Biology of the Cell. 14: 4376-86. PMID 12960427 DOI: 10.1091/Mbc.E03-05-0279  0.675
2003 Chen X, Leung SY, Yuen ST, Chu KM, Ji J, Li R, Chan AS, Law S, Troyanskaya OG, Wong J, So S, Botstein D, Brown PO. Variation in gene expression patterns in human gastric cancers. Molecular Biology of the Cell. 14: 3208-15. PMID 12925757 DOI: 10.1091/Mbc.E02-12-0833  0.651
2003 Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, Deng S, Johnsen H, Pesich R, Geisler S, Demeter J, Perou CM, Lønning PE, Brown PO, Børresen-Dale AL, ... Botstein D, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proceedings of the National Academy of Sciences of the United States of America. 100: 8418-23. PMID 12829800 DOI: 10.1073/Pnas.0932692100  0.513
2003 Troyanskaya OG, Dolinski K, Owen AB, Altman RB, Botstein D. A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae). Proceedings of the National Academy of Sciences of the United States of America. 100: 8348-53. PMID 12826619 DOI: 10.1073/Pnas.0832373100  0.707
2003 Segal E, Shapira M, Regev A, Pe'er D, Botstein D, Koller D, Friedman N. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data. Nature Genetics. 34: 166-76. PMID 12740579 DOI: 10.1038/Ng1165  0.398
2003 Alter O, Brown PO, Botstein D. Generalized singular value decomposition for comparative analysis of genome-scale expression data sets of two different organisms. Proceedings of the National Academy of Sciences of the United States of America. 100: 3351-6. PMID 12631705 DOI: 10.1073/Pnas.0530258100  0.796
2003 Botstein D, Risch N. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease. Nature Genetics. 33: 228-37. PMID 12610532 DOI: 10.1038/Ng1090  0.362
2003 Bohen SP, Troyanskaya OG, Alter O, Warnke R, Botstein D, Brown PO, Levy R. Variation in gene expression patterns in follicular lymphoma and the response to rituximab. Proceedings of the National Academy of Sciences of the United States of America. 100: 1926-30. PMID 12571354 DOI: 10.1073/Pnas.0437875100  0.802
2003 Ranade K, Hinds D, Hsiung CA, Chuang LM, Chang MS, Chen YT, Pesich R, Hebert J, Chen YD, Dzau V, Olshen R, Curb D, Botstein D, Cox DR, Risch N. A genome scan for hypertension susceptibility loci in populations of Chinese and Japanese origins. American Journal of Hypertension. 16: 158-62. PMID 12559686 DOI: 10.1016/S0895-7061(02)03245-4  0.315
2003 Diehn M, Sherlock G, Binkley G, Jin H, Matese JC, Hernandez-Boussard T, Rees CA, Cherry JM, Botstein D, Brown PO, Alizadeh AA. SOURCE: a unified genomic resource of functional annotations, ontologies, and gene expression data. Nucleic Acids Research. 31: 219-23. PMID 12519986 DOI: 10.1093/Nar/Gkg014  0.725
2003 Weng S, Dong Q, Balakrishnan R, Christie K, Costanzo M, Dolinski K, Dwight SS, Engel S, Fisk DG, Hong E, Issel-Tarver L, Sethuraman A, Theesfeld C, Andrada R, Binkley G, ... ... Botstein D, et al. Saccharomyces Genome Database (SGD) provides biochemical and structural information for budding yeast proteins. Nucleic Acids Research. 31: 216-8. PMID 12519985 DOI: 10.1093/Nar/Gkg054  0.31
2003 Gollub J, Ball CA, Binkley G, Demeter J, Finkelstein DB, Hebert JM, Hernandez-Boussard T, Jin H, Kaloper M, Matese JC, Schroeder M, Brown PO, Botstein D, Sherlock G. The Stanford Microarray Database: data access and quality assessment tools. Nucleic Acids Research. 31: 94-6. PMID 12519956 DOI: 10.1093/Nar/Gkg078  0.639
2002 Wang W, Cherry JM, Botstein D, Li H. A systematic approach to reconstructing transcription networks in Saccharomycescerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 99: 16893-8. PMID 12482955 DOI: 10.1073/Pnas.252638199  0.409
2002 Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, ... ... Botstein D, et al. Overview of the Alliance for Cellular Signaling. Nature. 420: 703-6. PMID 12478301 DOI: 10.1038/Nature01304  0.463
2002 van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J, Torhorst J, Sauter G, Zuber M, Köchli OR, Mross F, Dieterich H, Seitz R, Ross D, Botstein D, et al. Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome. The American Journal of Pathology. 161: 1991-6. PMID 12466114 DOI: 10.1016/S0002-9440(10)64476-8  0.449
2002 Leung SY, Chen X, Chu KM, Yuen ST, Mathy J, Ji J, Chan AS, Li R, Law S, Troyanskaya OG, Tu IP, Wong J, So S, Botstein D, Brown PO. Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis. Proceedings of the National Academy of Sciences of the United States of America. 99: 16203-8. PMID 12456890 DOI: 10.1073/Pnas.212646299  0.663
2002 Dunham MJ, Badrane H, Ferea T, Adams J, Brown PO, Rosenzweig F, Botstein D. Characteristic genome rearrangements in experimental evolution of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 99: 16144-9. PMID 12446845 DOI: 10.1073/Pnas.242624799  0.694
2002 Troyanskaya OG, Garber ME, Brown PO, Botstein D, Altman RB. Nonparametric methods for identifying differentially expressed genes in microarray data. Bioinformatics (Oxford, England). 18: 1454-61. PMID 12424116 DOI: 10.1093/Bioinformatics/18.11.1454  0.742
2002 Chang HY, Chi JT, Dudoit S, Bondre C, van de Rijn M, Botstein D, Brown PO. Diversity, topographic differentiation, and positional memory in human fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 99: 12877-82. PMID 12297622 DOI: 10.1073/Pnas.162488599  0.555
2002 Pollack JR, Sørlie T, Perou CM, Rees CA, Jeffrey SS, Lonning PE, Tibshirani R, Botstein D, Børresen-Dale AL, Brown PO. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors. Proceedings of the National Academy of Sciences of the United States of America. 99: 12963-8. PMID 12297621 DOI: 10.1073/Pnas.162471999  0.595
2002 Diehn M, Alizadeh AA, Rando OJ, Liu CL, Stankunas K, Botstein D, Crabtree GR, Brown PO. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proceedings of the National Academy of Sciences of the United States of America. 99: 11796-801. PMID 12195013 DOI: 10.1073/Pnas.092284399  0.496
2002 Sayama K, Diehn M, Matsuda K, Lunderius C, Tsai M, Tam SY, Botstein D, Brown PO, Galli SJ. Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11. Bmc Immunology. 3: 5. PMID 12079505 DOI: 10.1186/1471-2172-3-5  0.488
2002 Lossos IS, Alizadeh AA, Diehn M, Warnke R, Thorstenson Y, Oefner PJ, Brown PO, Botstein D, Levy R. Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes. Proceedings of the National Academy of Sciences of the United States of America. 99: 8886-91. PMID 12077300 DOI: 10.1073/Pnas.132253599  0.556
2002 Issel-Tarver L, Christie KR, Dolinski K, Andrada R, Balakrishnan R, Ball CA, Binkley G, Dong S, Dwight SS, Fisk DG, Harris M, Schroeder M, Sethuraman A, Tse K, Weng S, ... Botstein D, et al. Saccharomyces Genome Database. Methods in Enzymology. 350: 329-46. PMID 12073322 DOI: 10.1016/S0076-6879(02)50972-1  0.352
2002 Pollack JR, Van de Rijn M, Botstein D. Challenges in developing a molecular characterization of cancer. Seminars in Oncology. 29: 280-5. PMID 12063681 DOI: 10.1053/Sonc.2002.32903  0.348
2002 Whitfield ML, Sherlock G, Saldanha AJ, Murray JI, Ball CA, Alexander KE, Matese JC, Perou CM, Hurt MM, Brown PO, Botstein D. Identification of genes periodically expressed in the human cell cycle and their expression in tumors. Molecular Biology of the Cell. 13: 1977-2000. PMID 12058064 DOI: 10.1091/Mbc.02-02-0030  0.826
2002 Chen X, Cheung ST, So S, Fan ST, Barry C, Higgins J, Lai KM, Ji J, Dudoit S, Ng IO, Van De Rijn M, Botstein D, Brown PO. Gene expression patterns in human liver cancers. Molecular Biology of the Cell. 13: 1929-39. PMID 12058060 DOI: 10.1091/Mbc.02-02-0023  0.517
2002 Yoshimoto H, Saltsman K, Gasch AP, Li HX, Ogawa N, Botstein D, Brown PO, Cyert MS. Genome-wide analysis of gene expression regulated by the calcineurin/Crz1p signaling pathway in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 277: 31079-88. PMID 12058033 DOI: 10.1074/Jbc.M202718200  0.728
2002 Click ES, Stearns T, Botstein D. Systematic structure-function analysis of the small GTPase Arf1 in yeast. Molecular Biology of the Cell. 13: 1652-64. PMID 12006660 DOI: 10.1091/Mbc.02-01-0007  0.744
2002 Nielsen TO, West RB, Linn SC, Alter O, Knowling MA, O'Connell JX, Zhu S, Fero M, Sherlock G, Pollack JR, Brown PO, Botstein D, van de Rijn M. Molecular characterisation of soft tissue tumours: a gene expression study. Lancet (London, England). 359: 1301-7. PMID 11965276 DOI: 10.1016/S0140-6736(02)08270-3  0.806
2002 Boldrick JC, Alizadeh AA, Diehn M, Dudoit S, Liu CL, Belcher CE, Botstein D, Staudt LM, Brown PO, Relman DA. Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Proceedings of the National Academy of Sciences of the United States of America. 99: 972-7. PMID 11805339 DOI: 10.1073/Pnas.231625398  0.499
2002 Dwight SS, Harris MA, Dolinski K, Ball CA, Binkley G, Christie KR, Fisk DG, Issel-Tarver L, Schroeder M, Sherlock G, Sethuraman A, Weng S, Botstein D, Cherry JM. Saccharomyces Genome Database (SGD) provides secondary gene annotation using the Gene Ontology (GO). Nucleic Acids Research. 30: 69-72. PMID 11752257 DOI: 10.1093/Nar/30.1.69  0.665
2002 van der Pouw Kraan T, van Gaalen F, Kasperkovitz P, Verbeet N, Alizadeh A, Fero M, Huizinga T, Pieterman E, Breedveld F, Staudt L, Botstein D, Brown P, Verweij C. Arthritis Research. 4: 28. DOI: 10.1186/Ar468  0.504
2002 Sayama K, Diehn M, Matsuda K, Lunderius C, Tsai M, Tam SY, Botstein D, Brown PO, Galli SJ. Transcriptional response of human mast cells stimulated via the Fcε RI and identification of mast cells as a source of IL-11 Bmc Immunology. 3. DOI: 10.1186/1471-2172-3-5  0.378
2001 Rosenwald A, Alizadeh AA, Widhopf G, Simon R, Davis RE, Yu X, Yang L, Pickeral OK, Rassenti LZ, Powell J, Botstein D, Byrd JC, Grever MR, Cheson BD, Chiorazzi N, et al. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia. The Journal of Experimental Medicine. 194: 1639-47. PMID 11733578 DOI: 10.1084/Jem.194.11.1639  0.569
2001 Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, van de Rijn M, Rosen GD, Perou CM, Whyte RI, Altman RB, Brown PO, Botstein D, Petersen I. Diversity of gene expression in adenocarcinoma of the lung. Proceedings of the National Academy of Sciences of the United States of America. 98: 13784-9. PMID 11707590 DOI: 10.1073/Pnas.241500798  0.729
2001 Protchenko O, Ferea T, Rashford J, Tiedeman J, Brown PO, Botstein D, Philpott CC. Three cell wall mannoproteins facilitate the uptake of iron in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 276: 49244-50. PMID 11673473 DOI: 10.1074/Jbc.M109220200  0.498
2001 Gasch AP, Huang M, Metzner S, Botstein D, Elledge SJ, Brown PO. Genomic expression responses to DNA-damaging agents and the regulatory role of the yeast ATR homolog Mec1p. Molecular Biology of the Cell. 12: 2987-3003. PMID 11598186 DOI: 10.1091/Mbc.12.10.2987  0.729
2001 Lønning PE, Sørlie T, Perou CM, Brown PO, Botstein D, Børresen-Dale AL. Microarrays in primary breast cancer--lessons from chemotherapy studies. Endocrine-Related Cancer. 8: 259-63. PMID 11566617 DOI: 10.1677/Erc.0.0080259  0.429
2001 Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proceedings of the National Academy of Sciences of the United States of America. 98: 10869-74. PMID 11553815 DOI: 10.1073/Pnas.191367098  0.738
2001 Finlin BS, Gau CL, Murphy GA, Shao H, Kimel T, Seitz RS, Chiu YF, Botstein D, Brown PO, Der CJ, Tamanoi F, Andres DA, Perou CM. RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer. The Journal of Biological Chemistry. 276: 42259-67. PMID 11533059 DOI: 10.1074/Jbc.M105888200  0.44
2001 Lieb JD, Liu X, Botstein D, Brown PO. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nature Genetics. 28: 327-34. PMID 11455386 DOI: 10.1038/Ng569  0.552
2001 Troyanskaya O, Cantor M, Sherlock G, Brown P, Hastie T, Tibshirani R, Botstein D, Altman RB. Missing value estimation methods for DNA microarrays Bioinformatics. 17: 520-525. PMID 11395428 DOI: 10.1093/Bioinformatics/17.6.520  0.764
2001 Iyer VR, Horak CE, Scafe CS, Botstein D, Snyder M, Brown PO. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature. 409: 533-8. PMID 11206552 DOI: 10.1038/35054095  0.594
2001 Hastie T, Tibshirani R, Botstein D, Brown P. Supervised harvesting of expression trees Genome Biology. 2: RESEARCH0003. PMID 11178280 DOI: 10.1186/Gb-2001-2-1-Research0003  0.563
2001 Carmel-Harel O, Stearman R, Gasch AP, Botstein D, Brown PO, Storz G. Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae. Molecular Microbiology. 39: 595-605. PMID 11169101 DOI: 10.1046/J.1365-2958.2001.02255.X  0.733
2001 Sherlock G, Hernandez-Boussard T, Kasarskis A, Binkley G, Matese JC, Dwight SS, Kaloper M, Weng S, Jin H, Ball CA, Eisen MB, Spellman PT, Brown PO, Botstein D, Cherry JM. The Stanford Microarray Database. Nucleic Acids Research. 29: 152-5. PMID 11125075 DOI: 10.1093/Nar/29.1.152  0.773
2001 Ball CA, Jin H, Sherlock G, Weng S, Matese JC, Andrada R, Binkley G, Dolinski K, Dwight SS, Harris MA, Issel-Tarver L, Schroeder M, Botstein D, Cherry JM. Saccharomyces genome database provides tools to survey gene expression and functional analysis data Nucleic Acids Research. 29: 80-81. PMID 11125055 DOI: 10.1093/Nar/29.1.80  0.645
2001 Alter O, Brown PO, Botstein D. Processing and modeling genome-wide expression data using singular value decomposition Proceedings of Spie - the International Society For Optical Engineering. 4266: 171-186. DOI: 10.1117/12.427986  0.785
2001 Novoradovskaya N, Chin N, Payette T, Pergamenschikov A, Fero M, Botstein D, Braman J. Using universal human reference RNA in microarray gene expression studies Nature Genetics. 27: 76-76. DOI: 10.1038/87228  0.354
2001 Diehn M, Eisen MB, Botstein D, Brown PO. From gene expression to the bedside: A high-throughput approach for identifying serum diagnostic markers and immunotherapy targets in human malignancies using DNA microarrays Nature Genetics. 27: 50-50. DOI: 10.1038/87056  0.754
2000 Lee SE, Pellicioli A, Demeter J, Vaze MP, Gasch AP, Malkova A, Brown PO, Botstein D, Stearns T, Foiani M, Haber JE. Arrest, adaptation, and recovery following a chromosome double-strand break in Saccharomyces cerevisiae. Cold Spring Harbor Symposia On Quantitative Biology. 65: 303-14. PMID 12760044 DOI: 10.1101/Sqb.2000.65.303  0.712
2000 Hastie T, Tibshirani R, Eisen MB, Alizadeh A, Levy R, Staudt L, Chan WC, Botstein D, Brown P. 'Gene shaving' as a method for identifying distinct sets of genes with similar expression patterns. Genome Biology. 1: RESEARCH0003. PMID 11178228 DOI: 10.1186/Gb-2000-1-2-Research0003  0.777
2000 Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, Storz G, Botstein D, Brown PO. Genomic expression programs in the response of yeast cells to environmental changes. Molecular Biology of the Cell. 11: 4241-57. PMID 11102521 DOI: 10.1091/Mbc.11.12.4241  0.815
2000 Khodursky AB, Peter BJ, Cozzarelli NR, Botstein D, Brown PO, Yanofsky C. DNA microarray analysis of gene expression in response to physiological and genetic changes that affect tryptophan metabolism in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 97: 12170-5. PMID 11027315 DOI: 10.1073/Pnas.220414297  0.555
2000 Alter O, Brown PO, Botstein D. Singular value decomposition for genome-Wide expression data processing and modeling Proceedings of the National Academy of Sciences of the United States of America. 97: 10101-10106. PMID 10963673 DOI: 10.1073/Pnas.97.18.10101  0.822
2000 Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lønning PE, ... ... Botstein D, et al. Molecular portraits of human breast tumours. Nature. 406: 747-52. PMID 10963602 DOI: 10.1038/35021093  0.764
2000 Lossos IS, Alizadeh AA, Eisen MB, Chan WC, Brown PO, Botstein D, Staudt LM, Levy R. Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas. Proceedings of the National Academy of Sciences of the United States of America. 97: 10209-13. PMID 10954754 DOI: 10.1073/Pnas.180316097  0.754
2000 Khodursky AB, Peter BJ, Schmid MB, DeRisi J, Botstein D, Brown PO, Cozzarelli NR. Analysis of topoisomerase function in bacterial replication fork movement: use of DNA microarrays. Proceedings of the National Academy of Sciences of the United States of America. 97: 9419-24. PMID 10944214 DOI: 10.1073/Pnas.97.17.9419  0.521
2000 Zhu G, Spellman PT, Volpe T, Brown PO, Botstein D, Davis TN, Futcher B. Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth. Nature. 406: 90-4. PMID 10894548 DOI: 10.1038/35017581  0.684
2000 Lyons TJ, Gasch AP, Gaither LA, Botstein D, Brown PO, Eide DJ. Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Proceedings of the National Academy of Sciences of the United States of America. 97: 7957-62. PMID 10884426 DOI: 10.1073/Pnas.97.14.7957  0.752
2000 Diehn M, Eisen MB, Botstein D, Brown PO. Large-scale identification of secreted and membrane-associated gene products using DNA microarrays. Nature Genetics. 25: 58-62. PMID 10802657 DOI: 10.1038/75603  0.757
2000 Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature Genetics. 25: 25-9. PMID 10802651 DOI: 10.1038/75556  0.727
2000 Yun CW, Ferea T, Rashford J, Ardon O, Brown PO, Botstein D, Kaplan J, Philpott CC. Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake Journal of Biological Chemistry. 275: 10709-10715. PMID 10744769 DOI: 10.1074/Jbc.275.14.10709  0.481
2000 Scherf U, Ross DT, Waltham M, Smith LH, Lee JK, Tanabe L, Kohn KW, Reinhold WC, Myers TG, Andrews DT, Scudiero DA, Eisen MB, Sausville EA, Pommier Y, Botstein D, et al. A gene expression database for the molecular pharmacology of cancer. Nature Genetics. 24: 236-44. PMID 10700175 DOI: 10.1038/73439  0.762
2000 Ross DT, Scherf U, Eisen MB, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, Van de Rijn M, Waltham M, Pergamenschikov A, Lee JC, Lashkari D, Shalon D, Myers TG, ... ... Botstein D, et al. Systematic variation in gene expression patterns in human cancer cell lines. Nature Genetics. 24: 227-35. PMID 10700174 DOI: 10.1038/73432  0.795
2000 Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, Powell JI, Yang L, Marti GE, Moore T, Hudson J, ... ... Botstein D, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 403: 503-11. PMID 10676951 DOI: 10.1038/35000501  0.8
2000 Friddle C, Koskela R, Ranade K, Hebert J, Cargill M, Clark CD, McInnis M, Simpson S, McMahon F, Stine OC, Meyers D, Xu J, MacKinnon D, Swift-Scanlan T, Jamison K, ... ... Botstein D, et al. Full-genome scan for linkage in 50 families segregating the bipolar affective disease phenotype. American Journal of Human Genetics. 66: 205-15. PMID 10631152 DOI: 10.1086/302697  0.302
2000 Ball CA, Dolinski K, Dwight SS, Harris MA, Issel-Tarver L, Kasarskis A, Scafe CR, Sherlock G, Binkley G, Jin H, Kaloper M, Orr SD, Schroeder M, Weng S, Zhu Y, ... Botstein D, et al. Integrating functional genomic information into the Saccharomyces Genome Database Nucleic Acids Research. 28: 77-80. PMID 10592186 DOI: 10.1093/Nar/28.1.77  0.641
2000 Schwartz K, Richards K, Botstein D. BIM1 encodes a microtubule-binding protein in yeast. Molecular Biology of the Cell. 8: 2677-91. PMID 9398684 DOI: 10.1091/Mbc.8.12.2677  0.377
2000 Botstein D, Brown P. Studying breast cancer on a genomic scale using DNA microarrays Breast Cancer Research. 2. DOI: 10.1186/Bcr196  0.409
2000 Sørlie T, Perou C, Lønning P, Brown P, Botstein D, Børresen-Dale A. Relation of gene expression-based tumor subclasses to clinical phenotypes Breast Cancer Research. 2. DOI: 10.1186/Bcr180  0.526
2000 Perou CM, Brown PO, Botstein D. Tumor classification using gene expression patterns from DNA microarrays Trends in Ecology and Evolution. 67-76.  0.489
1999 Alizadeh A, Eisen M, Davis RE, Ma C, Sabet H, Tran T, Powell JI, Yang L, Marti GE, Moore DT, Hudson JR, Chan WC, Greiner T, Weisenburger D, Armitage JO, ... ... Botstein D, et al. The lymphochip: a specialized cDNA microarray for the genomic-scale analysis of gene expression in normal and malignant lymphocytes. Cold Spring Harbor Symposia On Quantitative Biology. 64: 71-8. PMID 11232339 DOI: 10.1101/Sqb.1999.64.71  0.768
1999 Pollack JR, Perou CM, Alizadeh AA, Eisen MB, Pergamenschikov A, Williams CF, Jeffrey SS, Botstein D, Brown PO. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nature Genetics. 23: 41-6. PMID 10471496 DOI: 10.1038/12640  0.767
1999 Ferea TL, Botstein D, Brown PO, Rosenzweig RF. Systematic changes in gene expression patterns following adaptive evolution in yeast. Proceedings of the National Academy of Sciences of the United States of America. 96: 9721-6. PMID 10449761 DOI: 10.1073/pnas.96.17.9721  0.506
1999 Perou CM, Jeffrey SS, van de Rijn M, Rees CA, Eisen MB, Ross DT, Pergamenschikov A, Williams CF, Zhu SX, Lee JC, Lashkari D, Shalon D, Brown PO, Botstein D. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proceedings of the National Academy of Sciences of the United States of America. 96: 9212-7. PMID 10430922 DOI: 10.1073/Pnas.96.16.9212  0.755
1999 Botstein D. Of genes and genomes Annals of the New York Academy of Sciences. 882: 32-41. PMID 10415884 DOI: 10.1111/J.1749-6632.1999.Tb08531.X  0.404
1999 Brown PO, Botstein D. Exploring the new world of the genome with DNA microarrays Nature Genetics. 21: 33-37. PMID 9915498 DOI: 10.1038/4462  0.58
1999 Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JC, Trent JM, Staudt LM, Hudson J, Boguski MS, Lashkari D, Shalon D, Botstein D, Brown PO. The transcriptional program in the response of human fibroblasts to serum. Science (New York, N.Y.). 283: 83-7. PMID 9872747 DOI: 10.1126/Science.283.5398.83  0.749
1999 Chervitz SA, Hester ET, Ball CA, Dolinski K, Dwight SS, Harris MA, Juvik G, Malekian A, Roberts S, Roe T, Scafe C, Schroeder M, Sherlock G, Weng S, Zhu Y, ... ... Botstein D, et al. Using the Saccharomyces Genome Database (SGD) for analysis of protein similarities and structure. Nucleic Acids Research. 27: 74-8. PMID 9847146 DOI: 10.1093/Nar/27.1.74  0.792
1999 Cali BM, Doyle TC, Botstein D, Fink GR. Multiple functions for actin during filamentous growth of Saccharomyces cerevisiae. Molecular Biology of the Cell. 9: 1873-89. PMID 9658177 DOI: 10.1091/Mbc.9.7.1873  0.49
1999 Weinstein J, Scherf U, Ross D, Waltham M, Reinhold R, Zhou Y, Scudiero D, Smith L, Lee J, Shalon D, Lashkari D, Eisen M, Myers T, Sausville E, Botstein D, et al. A cDNA microarray gene expression database for cancer drug discovery Nature Genetics. 23: 81-81. DOI: 10.1038/14426  0.746
1999 Spellman P, Gasch A, Eisen M, Kao C, Brown P, Botstein D. Functional clustering of genes using microarray gene expression data Nature Genetics. 23: 75-75. DOI: 10.1038/14406  0.815
1999 Pollack JR, Perou CM, Sorlie T, Alizadeh AA, Rees C, Eise MB, Pergamenschikov A, Williams CF, van de Rijn M, Jeffrey SS, Johnsen H, Lonning PE, Geisler S, Aas T, Borresen-Dale A, ... Botstein D, et al. Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays Nature Genetics. 23: 69-69. DOI: 10.1038/14385  0.501
1999 Iyer VR, Horak C, Kuras L, Kosa P, Scafe C, Botstein D, Struhl K, Snyder M, Brown PO. Genome-wide maps of DNA-protein interactions using a yeast ORF and intergenic microarray Nature Genetics. 23: 53-53. DOI: 10.1038/14332  0.523
1999 Alizadeh A, Eisen MB, Davis RE, Powell JI, Yang L, Hart RR, Sabet H, Tran TH, Yu X, Ma C, Chan WC, Greiner TC, Weisenburger DD, Armitage JO, Lossos I, ... ... Botstein D, et al. Analysis of gene expression in normal and malignant lymphocytes using the Lymphochip cDNA microarray Nature Genetics. 23: 30-31. DOI: 10.1038/14260  0.767
1998 Dolinski K, Ball CA, Chervitz SA, Dwight SS, Harris MA, Roberts S, Roe T, Cherry JM, Botstein D. Expanding yeast knowledge online. Yeast (Chichester, England). 14: 1453-69. PMID 9885151 DOI: 10.1002/(Sici)1097-0061(199812)14:16<1453::Aid-Yea348>3.0.Co;2-G  0.755
1998 Alizadeh A, Eisen M, Botstein D, Brown PO, Staudt LM. Probing lymphocyte biology by genomic-scale gene expression analysis Journal of Clinical Immunology. 18: 373-379. PMID 9857281 DOI: 10.1023/A:1023293621057  0.785
1998 Chervitz SA, Aravind L, Sherlock G, Ball CA, Koonin EV, Dwight SS, Harris MA, Dolinski K, Mohr S, Smith T, Weng S, Cherry JM, Botstein D. Comparison of the complete protein sets of worm and yeast: orthology and divergence. Science (New York, N.Y.). 282: 2022-8. PMID 9851918 DOI: 10.1126/Science.282.5396.2022  0.787
1998 Eisen MB, Spellman PT, Brown PO, Botstein D. Cluster analysis and display of genome-wide expression patterns. Proceedings of the National Academy of Sciences of the United States of America. 95: 14863-8. PMID 9843981 DOI: 10.1073/Pnas.95.25.14863  0.821
1998 Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J, Brush J, Taneyhill LA, Deuel B, Lew M, Watanabe C, Cohen RL, Melhem MF, Finley GG, Quirke P, ... ... Botstein D, et al. WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proceedings of the National Academy of Sciences of the United States of America. 95: 14717-22. PMID 9843955 DOI: 10.1073/Pnas.95.25.14717  0.364
1998 Spellman PT, Sherlock G, Zhang MQ, Iyer VR, Anders K, Eisen MB, Brown PO, Botstein D, Futcher B. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Molecular Biology of the Cell. 9: 3273-97. PMID 9843569 DOI: 10.1091/Mbc.9.12.3273  0.822
1998 Chu S, DeRisi J, Eisen M, Mulholland J, Botstein D, Brown PO, Herskowitz I. The transcriptional program of sporulation in budding yeast. Science (New York, N.Y.). 282: 699-705. PMID 9784122 DOI: 10.1126/Science.282.5389.699  0.828
1998 Cherry JM, Adler C, Ball C, Chervitz SA, Dwight SS, Hester ET, Jia Y, Juvik G, Roe T, Schroeder M, Weng S, Botstein D. SGD: Saccharomyces Genome Database. Nucleic Acids Research. 26: 73-9. PMID 9399804 DOI: 10.1093/Nar/26.1.73  0.766
1997 Botstein D, Chervitz SA, Cherry JM. Yeast as a model organism. Science (New York, N.Y.). 277: 1259-60. PMID 9297238 DOI: 10.1126/Science.277.5330.1259  0.772
1997 Mulholland J, Wesp A, Riezman H, Botstein D. Yeast actin cytoskeleton mutants accumulate a new class of Golgi-derived secretary vesicle. Molecular Biology of the Cell. 8: 1481-99. PMID 9285820 DOI: 10.1091/Mbc.8.8.1481  0.305
1997 Amberg DC, Zahner JE, Mulholland JW, Pringle JR, Botstein D. Aip3p/bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites Molecular Biology of the Cell. 8: 729-753. PMID 9247651 DOI: 10.1091/Mbc.8.4.729  0.655
1997 Botstein D, Cherry JM. Molecular linguistics: extracting information from gene and protein sequences. Proceedings of the National Academy of Sciences of the United States of America. 94: 5506-7. PMID 9159100 DOI: 10.1073/Pnas.94.11.5506  0.39
1997 Smith V, Chou KN, Lashkari D, Botstein D, Brown PO. Functional analysis of the genes of yeast chromosome V by genetic footprinting. Science (New York, N.Y.). 274: 2069-74. PMID 8953036 DOI: 10.1126/Science.274.5295.2069  0.578
1997 Botstein D, Amberg D, Mulholland J, Huffaker T, Adams A, Drubin D, Stearns T. 1 The Yeast Cytoskeleton Cold Spring Harbor Monograph Archive. 21: 1-90. DOI: 10.1101/087969364.21C.1  0.769
1997 Cherry JM, Ball C, Weng S, Juvik G, Schmidt R, Adler C, Dunn B, Dwight S, Riles L, Mortimer RK, Botstein D. Genetic and physical maps of Saccharomyces cerevisiae Nature. 387: 67-73. DOI: 10.1038/387s067  0.538
1995 Amberg DC, Botstein D, Beasley EM. Precise gene disruption in Saccharomyces cerevisiae by double fusion polymerase chain reaction Yeast. 11: 1275-1280. PMID 8553698 DOI: 10.1002/Yea.320111307  0.65
1995 Amberg DC, Basart E, Botstein D. Defining protein interactions with yeast actin in vivo. Nature Structural Biology. 2: 28-35. PMID 7719850 DOI: 10.1038/Nsb0195-28  0.616
1995 Smith V, Botstein D, Brown PO. Genetic footprinting: a genomic strategy for determining a gene's function given its sequence. Proceedings of the National Academy of Sciences of the United States of America. 92: 6479-83. PMID 7604017 DOI: 10.1073/Pnas.92.14.6479  0.555
1994 Ohya Y, Botstein D. Diverse essential functions revealed by complementing yeast calmodulin mutants. Science (New York, N.Y.). 263: 963-6. PMID 8310294 DOI: 10.1126/Science.8310294  0.35
1994 Ziman M, Preuss D, Mulholland J, O'Brien JM, Botstein D, Johnson DI. Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Molecular Biology of the Cell. 4: 1307-16. PMID 8167411 DOI: 10.1091/mbc.4.12.1307  0.618
1994 Mulholland J, Preuss D, Moon A, Wong A, Drubin D, Botstein D. Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. The Journal of Cell Biology. 125: 381-91. PMID 8163554 DOI: 10.1083/Jcb.125.2.381  0.616
1994 Qadota H, Anraku Y, Botstein D, Ohya Y. Conditional lethality of a yeast strain expressing human RHOA in place of RHO1. Proceedings of the National Academy of Sciences of the United States of America. 91: 9317-21. PMID 7937763 DOI: 10.1073/Pnas.91.20.9317  0.309
1994 Kolling R, Lee A, Chen EY, Botstein D. Nucleotide sequence of the SAC2 gene of Saccharomyces cerevisiae Yeast. 10: 1211-1216. PMID 7754710 DOI: 10.1002/Yea.320100909  0.383
1993 Kölling R, Nguyen T, Chen EY, Botstein D. A new yeast gene with a myosin-like heptad repeat structure Mgg Molecular & General Genetics. 237: 359-369. PMID 8483450 DOI: 10.1007/BF00279439  0.312
1993 Dunn B, Stearns T, Botstein D. Specificity domains distinguish the Ras-related GTPases Ypt1 and Sec4. Nature. 362: 563-5. PMID 8464499 DOI: 10.1038/362563A0  0.687
1992 Chen Y, Hennessy KM, Botstein D, Tye BK. CDC46/MCM5, a yeast protein whose subcellular localization is cell cycle-regulated, is involved in DNA replication at autonomously replicating sequences. Proceedings of the National Academy of Sciences of the United States of America. 89: 10459-63. PMID 1438234 DOI: 10.1073/Pnas.89.21.10459  0.641
1992 Preuss D, Mulholland J, Franzusoff A, Segev N, Botstein D. Characterization of the Saccharomyces Golgi complex through the cell cycle by immunoelectron microscopy. Molecular Biology of the Cell. 3: 789-803. PMID 1381247 DOI: 10.1091/Mbc.3.7.789  0.653
1992 Barnes G, Louie KA, Botstein D. Yeast proteins associated with microtubules in vitro and in vivo. Molecular Biology of the Cell. 3: 29-47. PMID 1348005 DOI: 10.1091/Mbc.3.1.29  0.315
1992 Palzkill T, Botstein D. Probing beta-lactamase structure and function using random replacement mutagenesis. Proteins. 14: 29-44. PMID 1329081 DOI: 10.1002/Prot.340140106  0.328
1992 Preuss D, Mulholland J, Franzusoff A, Segev N, Botstein D. Characterization of the Saccharomyces Golgl complex through the cell cycle by immunoelectron microscopy Trends in Cell Biology. 2: 326. DOI: 10.1016/0962-8924(92)90179-Q  0.591
1991 Hennessy KM, Lee A, Chen E, Botstein D. A group of interacting yeast DNA replication genes. Genes & Development. 5: 958-69. PMID 2044962 DOI: 10.1101/Gad.5.6.958  0.454
1991 Adams AE, Botstein D, Drubin DG. Requirement of yeast fimbrin for actin organization and morphogenesis in vivo. Nature. 354: 404-8. PMID 1956405 DOI: 10.1038/354404A0  0.301
1991 Preuss D, Mulholland J, Kaiser CA, Orlean P, Albright C, Rose MD, Robbins PW, Botstein D. Structure of the yeast endoplasmic reticulum: localization of ER proteins using immunofluorescence and immunoelectron microscopy. Yeast (Chichester, England). 7: 891-911. PMID 1803815 DOI: 10.1002/Yea.320070902  0.769
1991 Palzkill T, Botstein D. Extracting information from protein sequences using random replacement mutagenesis Methods. 3: 155-164. DOI: 10.1016/S1046-2023(05)80168-9  0.399
1990 Ma H, Bloom LM, Walsh CT, Botstein D. The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae. Molecular and Cellular Biology. 9: 5643-9. PMID 2685572 DOI: 10.1128/Mcb.9.12.5643  0.42
1990 Ma H, Bloom LM, Zhu ZM, Walsh CT, Botstein D. Isolation and characterization of mutations in the HXK2 gene of Saccharomyces cerevisiae. Molecular and Cellular Biology. 9: 5630-42. PMID 2685571 DOI: 10.1128/Mcb.9.12.5630  0.474
1990 Stearns T, Hoyt MA, Botstein D. Yeast mutants sensitive to antimicrotubule drugs define three genes that affect microtubule function. Genetics. 124: 251-62. PMID 2407611  0.571
1990 Kunes S, Botstein D, Fox MS. Synapsis-mediated fusion of free DNA ends forms inverted dimer plasmids in yeast. Genetics. 124: 67-80. PMID 2407606  0.8
1990 Hoyt MA, Stearns T, Botstein D. Chromosome instability mutants of Saccharomyces cerevisiae that are defective in microtubule-mediated processes. Molecular and Cellular Biology. 10: 223-34. PMID 2403635 DOI: 10.1128/Mcb.10.1.223  0.61
1990 Hennessy KM, Clark CD, Botstein D. Subcellular localization of yeast CDC46 varies with the cell cycle. Genes & Development. 4: 2252-63. PMID 2279699 DOI: 10.1101/Gad.4.12B.2252  0.329
1990 Stearns T, Ma H, Botstein D. Manipulating yeast genome using plasmid vectors. Methods in Enzymology. 185: 280-97. PMID 2199782 DOI: 10.1016/0076-6879(90)85025-J  0.704
1990 Kaiser CA, Botstein D. Efficiency and diversity of protein localization by random signal sequences. Molecular and Cellular Biology. 10: 3163-73. PMID 2160595 DOI: 10.1128/Mcb.10.6.3163  0.514
1990 Stearns T, Kahn RA, Botstein D, Hoyt MA. ADP ribosylation factor is an essential protein in Saccharomyces cerevisiae and is encoded by two genes. Molecular and Cellular Biology. 10: 6690-9. PMID 2123295 DOI: 10.1128/mcb.10.12.6690-6699.1990  0.645
1990 Stearns T, Willingham MC, Botstein D, Kahn RA. ADP-ribosylation factor is functionally and physically associated with the Golgi complex. Proceedings of the National Academy of Sciences of the United States of America. 87: 1238-42. PMID 2105501 DOI: 10.1073/Pnas.87.3.1238  0.592
1990 Baker D, Wuestehube L, Schekman R, Botstein D, Segev N. GTP-binding Ypt1 protein and Ca2+ function independently in a cell-free protein transport reaction. Proceedings of the National Academy of Sciences of the United States of America. 87: 355-9. PMID 2104983 DOI: 10.1073/Pnas.87.1.355  0.402
1989 Ma H, Bloom LM, Dakin SE, Walsh CT, Botstein D. The 15 N-terminal amino acids of hexokinase II are not required for in vivo function: analysis of a truncated form of hexokinase II in Saccharomyces cerevisiae. Proteins. 5: 218-23. PMID 2674934 DOI: 10.1002/Prot.340050305  0.413
1989 Preuss D, Botstein D. Intragenic revertants of yeast invertase variants with secretion-defective leader sequences. Molecular and Cellular Biology. 9: 1452-64. PMID 2657396 DOI: 10.1128/Mcb.9.4.1452  0.329
1989 Adams AE, Botstein D, Drubin DG. A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation. Science (New York, N.Y.). 243: 231-3. PMID 2643162 DOI: 10.1126/Science.2643162  0.369
1989 Holm C, Stearns T, Botstein D. DNA topoisomerase II must act at mitosis to prevent nondisjunction and chromosome breakage. Molecular and Cellular Biology. 9: 159-68. PMID 2538717 DOI: 10.1128/Mcb.9.1.159  0.488
1988 Huffaker TC, Hoyt MA, Botstein D. Genetic analysis of the yeast cytoskeleton. Annual Review of Genetics. 21: 259-84. PMID 3327466 DOI: 10.1146/Annurev.Ge.21.120187.001355  0.741
1988 Stearns T, Botstein D. Unlinked noncomplementation: isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae. Genetics. 119: 249-60. PMID 3294100  0.531
1988 Huffaker TC, Thomas JH, Botstein D. Diverse effects of β-tubulin mutations on microtubule formation and function Journal of Cell Biology. 106: 1997-2010. PMID 3290223 DOI: 10.1083/Jcb.106.6.1997  0.718
1988 Botstein D, Fink GR. Yeast: an experimental organism for modern biology. Science (New York, N.Y.). 240: 1439-43. PMID 3287619 DOI: 10.1126/Science.3287619  0.54
1988 Botstein D, Segev N, Stearns T, Hoyt MA, Holden J, Kahn RA. Diverse biological functions of small GTP-binding proteins in yeast. Cold Spring Harbor Symposia On Quantitative Biology. 53: 629-36. PMID 3151179 DOI: 10.1101/Sqb.1988.053.01.072  0.532
1988 Segev N, Mulholland J, Botstein D. The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery. Cell. 52: 915-24. PMID 3127057 DOI: 10.1016/0092-8674(88)90433-3  0.333
1988 Daub E, Zawadzke LE, Botstein D, Walsh CT. Isolation, cloning, and sequencing of the Salmonella typhimurium ddlA gene with purification and characterization of its product, D-alanine:D-alanine ligase (ADP forming). Biochemistry. 27: 3701-8. PMID 2841972 DOI: 10.1021/Bi00410A027  0.381
1987 Kunes S, Ma H, Overbye K, Fox MS, Botstein D. Fine structure recombinational analysis of cloned genes using yeast transformation. Genetics. 115: 73-81. PMID 3549444  0.809
1987 Kaiser CA, Preuss D, Grisafi P, Botstein D. Many random sequences functionally replace the secretion signal sequence of yeast invertase. Science (New York, N.Y.). 235: 312-7. PMID 3541205 DOI: 10.1126/Science.3541205  0.701
1987 Ma H, Botstein D. Effects of null mutations in the hexokinase genes of Saccharomyces cerevisiae on catabolite repression. Molecular and Cellular Biology. 6: 4046-52. PMID 3540605 DOI: 10.1128/MCB.6.11.4046  0.401
1987 Rose MD, Novick P, Thomas JH, Botstein D, Fink GR. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene. 60: 237-43. PMID 3327750 DOI: 10.1016/0378-1119(87)90232-0  0.775
1987 Segev N, Botstein D. The ras-like yeast YPT1 gene is itself essential for growth, sporulation, and starvation response. Molecular and Cellular Biology. 7: 2367-77. PMID 3302675 DOI: 10.1128/Mcb.7.7.2367  0.428
1987 Ma H, Kunes S, Schatz PJ, Botstein D. Plasmid construction by homologous recombination in yeast. Gene. 58: 201-16. PMID 2828185 DOI: 10.1016/0378-1119(87)90376-3  0.752
1986 Schatz PJ, Solomon F, Botstein D. Genetically essential and nonessential alpha-tubulin genes specify functionally interchangeable proteins. Molecular and Cellular Biology. 6: 3722-33. PMID 3540600 DOI: 10.1128/Mcb.6.11.3722  0.44
1986 Kaiser CA, Botstein D. Secretion-defective mutations in the signal sequence for Saccharomyces cerevisiae invertase. Molecular and Cellular Biology. 6: 2382-91. PMID 3537718  0.521
1986 Galakatos NG, Daub E, Botstein D, Walsh CT. Biosynthetic alr alanine racemase from Salmonella typhimurium: DNA and protein sequence determination. Biochemistry. 25: 3255-60. PMID 3524676 DOI: 10.1021/Bi00359A026  0.41
1986 Thomas JH, Botstein D. A gene required for the separation of chromosomes on the spindle apparatus in yeast Cell. 44: 65-76. PMID 3510081 DOI: 10.1016/0092-8674(86)90485-X  0.35
1986 Schatz PJ, Pillus L, Grisafi P, Solomon F, Botstein D. Two functional alpha-tubulin genes of the yeast Saccharomyces cerevisiae encode divergent proteins. Molecular and Cellular Biology. 6: 3711-21. PMID 3025610 DOI: 10.1128/Mcb.6.11.3711  0.426
1986 Brissenden JE, Page DC, de Martinville B, Trowsdale J, Botstein D, Francke U. Regional assignments of three polymorphic DNA segments on human chromosome 15. Genetic Epidemiology. 3: 231-9. PMID 3017806 DOI: 10.1002/Gepi.1370030404  0.463
1986 Holm C, Meeks-Wagner DW, Fangman WL, Botstein D. A rapid, efficient method for isolating DNA from yeast. Gene. 42: 169-73. PMID 3015730 DOI: 10.1016/0378-1119(86)90293-3  0.642
1986 Vergnaud G, Page DC, Simmler MC, Brown L, Rouyer F, Noel B, Botstein D, de la Chapelle A, Weissenbach J. A deletion map of the human Y chromosome based on DNA hybridization. American Journal of Human Genetics. 38: 109-24. PMID 3004206 DOI: 10.1097/00006254-198610000-00015  0.48
1986 Stachelek C, Stachelek J, Swan J, Botstein D, Konigsberg W. Identification, cloning and sequence determination of the genes specifying hexokinase A and B from yeast. Nucleic Acids Research. 14: 945-63. PMID 3003701 DOI: 10.1093/Nar/14.2.945  0.445
1986 Wertman KF, Wyman AR, Botstein D. Host/vector interactions which affect the viability of recombinant phage lambda clones. Gene. 49: 253-62. PMID 2952553 DOI: 10.1016/0378-1119(86)90286-6  0.366
1985 Wasserman SA, Daub E, Grisafi P, Botstein D, Walsh CT. Catabolic alanine racemase from Salmonella typhimurium: DNA sequence, enzyme purification, and characterization. Biochemistry. 23: 5182-7. PMID 6391537 DOI: 10.1021/Bi00317A015  0.353
1985 Novick P, Botstein D. Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell. 40: 405-16. PMID 3967297 DOI: 10.1016/0092-8674(85)90154-0  0.593
1985 Kunes S, Botstein D, Fox MS. Transformation of yeast with linearized plasmid DNA. Formation of inverted dimers and recombinant plasmid products. Journal of Molecular Biology. 184: 375-87. PMID 3900413 DOI: 10.1016/0022-2836(85)90288-8  0.793
1985 Botstein D, Shortle D. Strategies and applications of in vitro mutagenesis Science. 229: 1193-1201. PMID 2994214 DOI: 10.1126/Science.2994214  0.646
1985 Holm C, Goto T, Wang JC, Botstein D. DNA topoisomerase II is required at the time of mitosis in yeast. Cell. 41: 553-63. PMID 2985283 DOI: 10.1016/S0092-8674(85)80028-3  0.311
1984 Kunes S, Botstein D, Fox MS. Formation of inverted dimer plasmids after transformation of yeast with linearized plasmid DNA. Cold Spring Harbor Symposia On Quantitative Biology. 49: 617-28. PMID 6397317 DOI: 10.1101/Sqb.1984.049.01.070  0.783
1984 Neff NF, Thomas JH, Grisafi P, Botstein D. Isolation of the beta-tubulin gene from yeast and demonstration of its essential function in vivo. Cell. 33: 211-9. PMID 6380751 DOI: 10.1016/0092-8674(83)90350-1  0.364
1984 Shortle D, Novick P, Botstein D. Construction and genetic characterization of temperature-sensitive mutant alleles of the yeast actin gene Proceedings of the National Academy of Sciences of the United States of America. 81: 4889-4893. PMID 6379652 DOI: 10.1073/Pnas.81.15.4889  0.755
1984 Rose M, Grisafi P, Botstein D. Structure and function of the yeast URA3 gene: expression in Escherichia coli Gene. 29: 113-124. PMID 6092217 DOI: 10.1016/0378-1119(84)90172-0  0.654
1984 Page DC, Harper ME, Love J, Botstein D. Occurrence of a transposition from the X-chromosome long arm to the Y-chromosome short arm during human evolution. Nature. 311: 119-23. PMID 6088994 DOI: 10.1038/311119A0  0.454
1984 Novick P, Thomas JH, Botstein D. Genetic Analysis of Cytoskeletal Protein Function in Yeast Genetic Engineering. 6: 211-231. DOI: 10.1007/978-1-4684-4793-4_11  0.638
1983 Rose M, Botstein D. Structure and function of the yeast URA3 gene differentially regulated expression of hybrid β-galactosidase from overlapping coding sequences in yeast Journal of Molecular Biology. 170: 883-904. PMID 6315953 DOI: 10.1016/S0022-2836(83)80193-4  0.614
1983 Shortle D, Botstein D. Directed mutagenesis with sodium bisulfite Methods in Enzymology. 457-468. PMID 6312263 DOI: 10.1016/0076-6879(83)00073-7  0.666
1983 Rose M, Botstein D. Construction and use of gene fusions to lacZ (β-galactosidase) that are expressed in yeast Methods in Enzymology. 167-180. PMID 6310320 DOI: 10.1016/0076-6879(83)01012-5  0.599
1983 Wasserman SA, Walsh CT, Botstein D. Two alanine racemase genes in Salmonella typhimurium that differ in structure and function. Journal of Bacteriology. 153: 1439-1450. DOI: 10.1128/Jb.153.3.1439-1450.1983  0.424
1982 Shortle D, Haber JE, Botstein D. Lethal disruption of the yeast actin gene by integrative DNA transformation Science. 217: 371-373. PMID 7046050 DOI: 10.1126/Science.7046050  0.702
1982 Shortle D, Grisafi P, Benkovic SJ, Botstein D. Gap misrepair mutagenesis: Efficient site-directed induction of transition, transversion, and frameshift mutations in vitro Proceedings of the National Academy of Sciences of the United States of America. 79: 1588-1592. PMID 7041125 DOI: 10.1073/Pnas.79.5.1588  0.623
1982 Carlson M, Botstein D. Two differentially regulated mRNAs with different 5' ends encode secreted with intracellular forms of yeast invertase. Cell. 28: 145-54. PMID 7039847 DOI: 10.1016/0092-8674(82)90384-1  0.306
1982 Silverman SJ, Rose M, Botstein D, Fink GR. Regulation of HIS4-lacZ fusions in Saccharomyces cerevisiae Molecular and Cellular Biology. 2: 1212-1219. PMID 6817079 DOI: 10.1128/Mcb.2.10.1212  0.708
1982 Koshland D, Botstein D. Evidence for posttranslational translocation of beta-lactamase across the bacterial inner membrane. Cell. 30: 893-902. PMID 6754092 DOI: 10.1016/0092-8674(82)90294-X  0.591
1982 Page D, de Martinville B, Barker D, Wyman A, White R, Francke U, Botstein D. Single-copy sequence hybridizes to polymorphic and homologous loci on human X and Y chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 79: 5352-6. PMID 6291041 DOI: 10.1073/Pnas.79.17.5352  0.495
1982 Falco SC, Li Y, Broach JR, Botstein D. Genetic properties of chromosomally integrated 2 mu plasmid DNA in yeast. Cell. 29: 573-84. PMID 6288264 DOI: 10.1016/0092-8674(82)90173-8  0.326
1982 Shortle D, Botstein D. Single-stranded gaps as localized targets for in vitro mutagenesis Basic Life Sciences. 20: 147-155. PMID 6287991 DOI: 10.1007/978-1-4613-3476-7_8  0.632
1982 Koshland D, Sauer RT, Botstein D. Diverse effects of mutations in the signal sequence on the secretion of beta-lactamase in Salmonella typhimurium. Cell. 30: 903-14. PMID 6183007 DOI: 10.1016/0092-8674(82)90295-1  0.621
1982 Botstein D, Davis RW. Principles and Practice of Recombinant DNA Research with Yeast Cold Spring Harbor Monograph Archive. 607-636. DOI: 10.1101/087969180.11B.607  0.423
1981 Winston F, Botstein D. Control of lysogenization by phage P22. II. Mutations (clyA) in the cl gene that cause increased lysogenization. Journal of Molecular Biology. 152: 233-45. PMID 7328657 DOI: 10.1016/0022-2836(81)90241-2  0.56
1981 Winston F, Botstein D. Control of lysogenization by phage P22. I. The P22 cro gene. Journal of Molecular Biology. 152: 209-32. PMID 7328656 DOI: 10.1016/0022-2836(81)90240-0  0.533
1981 Carlson M, Osmond BC, Botstein D. SUC genes of yeast: a dispersed gene family. Cold Spring Harbor Symposia On Quantitative Biology. 799-803. PMID 7021054 DOI: 10.1101/Sqb.1981.045.01.098  0.384
1981 Rose M, Casadaban MJ, Botstein D. Yeast genes fused to β-galactosidase in Escherichia coli can be expressed normally in yeast Proceedings of the National Academy of Sciences of the United States of America. 78: 2460-2464. PMID 6787605 DOI: 10.1073/pnas.78.4.2460  0.614
1980 Koshland D, Botstein D. Secretion of beta-lactamase requires the carboxy end of the protein. Cell. 20: 749-60. PMID 6448092 DOI: 10.1016/0092-8674(80)90321-9  0.612
1980 Susskind MM, Botstein D. Superinfection exclusion by lambda prophage in lysogens of Salmonella typhimurium. Virology. 100: 212-6. PMID 6444259 DOI: 10.1016/0042-6822(80)90571-1  0.377
1980 Shortle D, Koshland D, Weinstock GM, Botstein D. Segment-directed mutagenesis: Construction in vitro of point mutations limited to a small predetermined region of a circular DNA molecule Proceedings of the National Academy of Sciences of the United States of America. 77: 5375-5379. PMID 6254078 DOI: 10.1073/Pnas.77.9.5375  0.782
1980 Weinstock GM, Botstein D. Genetics of bacteriophage P22. IV. Correlation of genetic and physical map using translocatable drug-resistance elements Virology. 106: 92-99. PMID 6251623 DOI: 10.1016/0042-6822(80)90224-X  0.479
1980 Weinstock GM, Riggs PD, Botstein D. Genetics of bacteriophage P22: III. The late operon Virology. 106: 82-91. PMID 6251622 DOI: 10.1016/0042-6822(80)90223-8  0.576
1979 Botstein D, Falco SC, Stewart SE, Brennan M, Scherer S, Stinchcomb DT, Struhl K, Davis RW. Sterile host yeasts (SHY): a eukaryotic system of biological containment for recombinant DNA experiments. Gene. 8: 17-24. PMID 395030 DOI: 10.1016/0378-1119(79)90004-0  0.325
1979 Poteete AR, Jarvik V, Botstein D. Encapsulation of phage P22 DNA in vitro. Virology. 95: 550-64. PMID 380139 DOI: 10.1016/0042-6822(79)90508-7  0.364
1979 Kleckner N, Reichardt K, Botstein D. Inversions and deletions of the Salmonella chromosome generated by the translocatable tetracycline resistance element Tn10. Journal of Molecular Biology. 127: 89-115. PMID 370414 DOI: 10.1016/0022-2836(79)90461-3  0.553
1979 Winston F, Botstein D, Miller JH. Characterization of amber and ochre suppressors in Salmonella typhimurium. Journal of Bacteriology. 137: 433-9. PMID 368021 DOI: 10.1128/Jb.137.1.433-439.1979  0.508
1979 Weinstock GM, Botstein D. Regional specificity of illegitimate recombination associated with the translocatable ampicillin-resistance element Tn1 Cold Spring Harbor Symposia On Quantitative Biology. 43: 1209-1215. PMID 290441 DOI: 10.1101/Sqb.1979.043.01.137  0.436
1979 Ross DG, Grisafi P, Kleckner N, Botstein D. The ends of Tn10 are not IS3. Journal of Bacteriology. 139: 1097-1101. DOI: 10.1128/Jb.139.3.1097-1101.1979  0.486
1978 Petes TD, Broach JR, Wensink PC, Hereford LM, Fink GR, Botstein D. Isolation and analysis of recombinant DNA molecules containing yeast DNA. Gene. 4: 37-49. PMID 365691 DOI: 10.1016/0378-1119(78)90013-6  0.68
1978 Kleckner N, Roth J, Botstein D. Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. Journal of Molecular Biology. 116: 125-59. PMID 338917 DOI: 10.1016/0022-2836(77)90123-1  0.572
1977 Petes TD, Hereford LM, Botstein D. Simple mendelian inheritance of the repeating yeast ribosomal DNA genes Cold Spring Harbor Symposia On Quantitative Biology. 42: 1201-1207. PMID 354850 DOI: 10.1101/Sqb.1978.042.01.121  0.636
1977 Petes TD, Botstein D. Simple Mendelian inheritance of the reiterated ribosomal DNA of yeast Proceedings of the National Academy of Sciences of the United States of America. 74: 5091-5095. PMID 337310 DOI: 10.1073/Pnas.74.11.5091  0.613
1977 King J, Botstein D, Casjens S, Earnshaw W, Harrison S, Lenk E. Structure and assembly of the capsid of bacteriophage P22. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 276: 37-49. PMID 13434 DOI: 10.1098/Rstb.1976.0096  0.332
1976 Hilliker S, Botstein D. Specificity of genetic elements controlling regulation of early functions in temperate bacteriophages. Journal of Molecular Biology. 106: 537-66. PMID 978735 DOI: 10.1016/0022-2836(76)90251-5  0.394
1976 Roberts JW, Roberts CW, Hilliker S, Botstein D. Transcription Termination and Regulation in Bacteriophages P22 and Lambda Cold Spring Harbor Monograph Archive. 6: 707-718. DOI: 10.1101/087969115.6.707  0.398
1975 Hilliker S, Botstein D. An early regulatory gene of Salmonella phage P22 analogous to gene N of coliphage lambda. Virology. 68: 510-24. PMID 1105960 DOI: 10.1016/0042-6822(75)90291-3  0.391
1975 Kleckner N, Chan RK, Tye BK, Botstein D. Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition Journal of Molecular Biology. 97. PMID 1102715 DOI: 10.1016/S0022-2836(75)80059-3  0.722
1975 Jarvik J, Botstein D. Conditional-lethal mutations that suppress genetic defects in morphogenesis by altering structural proteins. Proceedings of the National Academy of Sciences of the United States of America. 72: 2738-42. PMID 1101263 DOI: 10.1073/Pnas.72.7.2738  0.336
1974 Tye BK, Chan RK, Botstein D. Packaging of an oversize transducing genome by Salmonella phage P22 Journal of Molecular Biology. 85. PMID 4853525 DOI: 10.1016/0022-2836(74)90311-8  0.608
1974 Tye BK, Huberman JA, Botstein D. Non-random circular permutation of phage P22 DNA. Journal of Molecular Biology. 85: 501-28. PMID 4853363 DOI: 10.1016/0022-2836(74)90312-X  0.596
1974 Young IT, Levinstone D, Eden M, Tye BK, Botstein D. Alignment of partial denaturation maps of circularly permuted DNA by computer Journal of Molecular Biology. 85: 528-532. PMID 4850477 DOI: 10.1016/0022-2836(74)90313-1  0.57
1974 King J, Lenk EV, Botstein D. Mechanism of head assembly and DNA encapsulation in Salmonella phage P22. II. Morphogenetic pathway. Journal of Molecular Biology. 80: 697-731. PMID 4773027 DOI: 10.1016/0022-2836(73)90205-2  0.376
1974 Botstein D, Waddell CH, King J. Mechanism of head assembly and DNA encapsulation in Salmonella phage p22. I. Genes, proteins, structures and DNA maturation. Journal of Molecular Biology. 80: 669-95. PMID 4773026 DOI: 10.1016/0022-2836(73)90204-0  0.4
1974 Tye BK, Botstein D. P22 morphogenesis. II: Mechanism of DNA encapsulation Journal of Supramolecular Structure. 2: 225-238. PMID 4612248 DOI: 10.1002/Jss.400020216  0.599
1974 Botstein D, Herskowitz I. Properties of hybrids between Salmonella phage P22 and coliphage lambda. Nature. 251: 584-9. PMID 4608090 DOI: 10.1038/251584A0  0.597
1972 Ebel-Tsipis J, Fox MS, Botstein D. Generalized transduction by bacteriophage P22 in Salmonella typhimurium. II. Mechanism of integration of transducing DNA. Journal of Molecular Biology. 71: 449-69. PMID 4564487 DOI: 10.1016/0022-2836(72)90362-2  0.682
1972 Ebel-Tsipis J, Botstein D, Fox MS. Generalized transduction by phage P22 in Salmonella typhimurium. I. Molecular origin of transducing DNA. Journal of Molecular Biology. 71: 433-48. PMID 4564486 DOI: 10.1016/0022-2836(72)90361-0  0.67
1972 Botstein D, Chan RK, Waddell CH. Genetics of bacteriophage P22. II. Gene order and gene function. Virology. 49: 268-82. PMID 4556926 DOI: 10.1016/S0042-6822(72)80028-X  0.31
1968 Botstein D, Levine M. Synthesis and maturation of phage P22 DNA. II. Properties of temperature-sensitive phage mutants defective in DNA metabolism. Journal of Molecular Biology. 34: 643-54. PMID 4938562 DOI: 10.1016/0022-2836(68)90186-1  0.365
1968 Botstein D, Levine M. Intermediates in the synthesis of phage P22 DNA. Cold Spring Harbor Symposia On Quantitative Biology. 33: 659-67. PMID 4892003 DOI: 10.1101/Sqb.1968.033.01.075  0.334
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