| Year |
Citation |
Score |
| 2024 |
Wilson PG, Abdelmoti L, Gao T, Galperin E. The expression of congenital Shoc2 variants induces AKT-dependent crosstalk activation of the ERK1/2 pathway. Human Molecular Genetics. PMID 38881369 DOI: 10.1093/hmg/ddae100 |
0.421 |
|
| 2023 |
Wilson P, Abdelmoti L, Gao T, Galperin E. The expression of congenital Shoc2 variants induces AKT-dependent feedback activation of the ERK1/2 pathway. Biorxiv : the Preprint Server For Biology. PMID 38187642 DOI: 10.1101/2023.12.23.573219 |
0.414 |
|
| 2023 |
Hasani S, Young LEA, Van Nort W, Banerjee M, Rivas DR, Kim J, Xiong X, Sun RC, Gentry MS, Sesaki H, Gao T. Inhibition of mitochondrial fission activates glycogen synthesis to support cell survival in colon cancer. Cell Death & Disease. 14: 664. PMID 37816729 DOI: 10.1038/s41419-023-06202-3 |
0.306 |
|
| 2021 |
Xie Y, Zhang W, Guo L, Kril LM, Begley KL, Sviripa VM, Chen X, Liu X, Lee EY, He D, Wang C, Gao T, Liu X, Evers BM, Watt DS, et al. Potent Synergistic Effect on c-Myc Driven Colorectal Cancers Using a Novel Indole-Substituted Quinoline with a Plk1 Inhibitor. Molecular Cancer Therapeutics. PMID 34376582 DOI: 10.1158/1535-7163.MCT-20-1017 |
0.324 |
|
| 2020 |
Gan T, Stevens AT, Xiong X, Wen YA, Farmer TN, Li AT, Stevens PD, Golshani S, Weiss HL, Mark Evers B, Gao T. Inhibition of protein tyrosine phosphatase receptor type F suppresses Wnt signaling in colorectal cancer. Oncogene. PMID 32973331 DOI: 10.1038/s41388-020-01472-z |
0.391 |
|
| 2020 |
Xiong X, Wen YA, Fairchild R, Zaytseva YY, Weiss HL, Evers BM, Gao T. Upregulation of CPT1A is essential for the tumor-promoting effect of adipocytes in colon cancer. Cell Death & Disease. 11: 736. PMID 32913185 DOI: 10.1038/S41419-020-02936-6 |
0.359 |
|
| 2020 |
Jang H, Stevens P, Gao T, Galperin E. The Leucine-Rich Repeats Signaling Scaffolds Shoc2 and Erbin: Cellular Mechanism and Role in Disease. The Febs Journal. PMID 32558243 DOI: 10.1111/Febs.15450 |
0.359 |
|
| 2020 |
Li J, Li X, Song J, Yan B, Rock SA, Jia J, Liu J, Wang C, Weiss T, Weiss HL, Gao T, Alam A, Evers BM. Absence of neurotensin attenuates intestinal dysbiosis and inflammation by maintaining Mmp7/α-defensin axis in diet-induced obese mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32359121 DOI: 10.1096/Fj.201902374Rr |
0.328 |
|
| 2020 |
Banerjee M, Li Z, Gao Y, Huang M, Cai L, Gao T, Zijian X. Abstract 6393: Targeting the increased endocytosis of Na/K ATPase α1 subunit as a new therapeutic approach to prostate cancer Cancer Research. 80: 6393-6393. DOI: 10.1158/1538-7445.Am2020-6393 |
0.335 |
|
| 2020 |
Hasani SR, Xiong X, Gao T. The role of PHLPP in regulating mitochondrial dynamics in colorectal cancer The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03544 |
0.304 |
|
| 2019 |
Wang Z, Li Y, Xiao Y, Lin HP, Yang P, Humphries B, Gao T, Yang C. Integrin α9 depletion promotes β-catenin degradation to suppress triple negative breast cancer tumor growth and metastasis. International Journal of Cancer. PMID 31008533 DOI: 10.1002/Ijc.32359 |
0.394 |
|
| 2019 |
Rock S, Li X, Song J, Townsend CM, Weiss HL, Rychahou P, Gao T, Li J, Evers BM. Kinase suppressor of Ras 1 and Exo70 promote fatty acid-stimulated neurotensin secretion through ERK1/2 signaling. Plos One. 14: e0211134. PMID 30917119 DOI: 10.1371/Journal.Pone.0211134 |
0.522 |
|
| 2019 |
Wen YA, Xiong X, Scott T, Li AT, Wang C, Weiss HL, Tan L, Bradford E, Fan TWM, Chandel NS, Barrett TA, Gao T. The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer. Cell Death and Differentiation. PMID 30659235 DOI: 10.1038/S41418-018-0265-6 |
0.44 |
|
| 2019 |
Peng W, Li J, Song J, Xiaopeng X, Gao T, Evers BM. Tu2035 – Neurotensin Promotes Epithelial-Mesenchymal Transformation Via Erk Signaling Pathway in Colorectal Cancer Gastroenterology. 156: S-1176. DOI: 10.1016/S0016-5085(19)39913-5 |
0.411 |
|
| 2019 |
Song J, Li J, Weiss HL, Gao T, Evers BM. 445 – Nt-Ntr1 Signaling Positively Regulates Intestinal Fatty Acid Uptake and Lipogenesis Gastroenterology. 156: S-93. DOI: 10.1016/S0016-5085(19)37018-0 |
0.323 |
|
| 2018 |
Xiong G, Stewart RL, Chen J, Gao T, Scott TL, Samayoa LM, O'Connor K, Lane AN, Xu R. Collagen prolyl 4-hydroxylase 1 is essential for HIF-1α stabilization and TNBC chemoresistance. Nature Communications. 9: 4456. PMID 30367042 DOI: 10.1038/S41467-018-06893-9 |
0.366 |
|
| 2018 |
Jafari N, Drury J, Morris AJ, Onono FO, Stevens PD, Gao T, Liu J, Wang C, Lee EY, Weiss HL, Evers BM, Zaytseva YY. De Novo Fatty Acid Synthesis Driven Sphingolipid Metabolism Promotes Metastatic Potential of Colorectal Cancer. Molecular Cancer Research : McR. PMID 30154249 DOI: 10.1158/1541-7786.Mcr-18-0199 |
0.404 |
|
| 2018 |
Banerjee M, Cui X, Li Z, Yu H, Cai L, Jia X, He D, Wang C, Gao T, Xie Z. Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth. Scientific Reports. 8: 12322. PMID 30120256 DOI: 10.1038/S41598-018-29995-2 |
0.363 |
|
| 2018 |
Dhar SK, Bakthavatchalu V, Dhar B, Chen J, Tadahide I, Zhu H, Gao T, St Clair DK. DNA polymerase gamma (Polγ) deficiency triggers a selective mTORC2 prosurvival autophagy response via mitochondria-mediated ROS signaling. Oncogene. PMID 30038268 DOI: 10.1038/S41388-018-0404-Z |
0.368 |
|
| 2018 |
Stevens PD, Wen YA, Xiong X, Zaytseva YY, Li AT, Wang C, Stevens AT, Farmer TN, Gan T, Weiss HL, Inagaki M, Marchetto S, Borg JP, Gao T. Erbin suppresses KSR1-mediated RAS/RAF signaling and tumorigenesis in colorectal cancer. Cancer Research. PMID 29980571 DOI: 10.1158/0008-5472.Can-17-3629 |
0.486 |
|
| 2018 |
Zaytseva YY, Rychahou PG, Le AT, Scott TL, Flight RM, Kim JT, Harris J, Liu J, Wang C, Morris AJ, Sivakumaran TA, Fan T, Moseley H, Gao T, Lee EY, et al. Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer. Oncotarget. 9: 24787-24800. PMID 29872506 DOI: 10.18632/Oncotarget.25361 |
0.369 |
|
| 2018 |
Li J, Song J, Li X, Rock SB, Sinner HF, Weiss HL, Weiss T, Townsend CM, Gao T, Evers BM. FFAR4 is involved in regulation of neurotensin release from neuroendocrine cells and male C57BL/6 mice. Endocrinology. PMID 29796668 DOI: 10.1210/En.2018-00284 |
0.34 |
|
| 2018 |
Wen YA, Xiong X, Zaytseva YY, Napier DL, Vallee E, Li AT, Wang C, Weiss HL, Evers BM, Gao T. Downregulation of SREBP inhibits tumor growth and initiation by altering cellular metabolism in colon cancer. Cell Death & Disease. 9: 265. PMID 29449559 DOI: 10.1038/S41419-018-0330-6 |
0.41 |
|
| 2018 |
Goretsky T, Bradford EM, Ye Q, Lamping OF, Vanagunas T, Moyer MP, Keller PC, Sinh P, Llovet JM, Gao T, She QB, Li L, Barrett TA. Beta-catenin cleavage enhances transcriptional activation. Scientific Reports. 8: 671. PMID 29330435 DOI: 10.1038/S41598-017-18421-8 |
0.362 |
|
| 2018 |
Wen Y, Xiong X, Zaytseva Y, Gao T. Abstract 3494: Downregulation of SREBPs inhibited colon cancer cell growth and tumor initiation by alteration of metabolism Cancer Research. 78: 3494-3494. DOI: 10.1158/1538-7445.Am2018-3494 |
0.42 |
|
| 2018 |
Gan T, Stevens PD, Wen Y, Xiaopeng X, Sanam G, Farmer TN, Evers BM, Gao T. Su1774 - Suppression of Tyrosine Phosphatase Ptprf Inhibits Wnt Signaling and Tumorigenesis in Colorectal Cancer Gastroenterology. 154: S-585. DOI: 10.1016/S0016-5085(18)32137-1 |
0.43 |
|
| 2018 |
Li J, Song J, Gao T, Jia J, Evers BM. Su1204 - NTR3 Interacts with NTR1 to Extend the Duration of Neurotensin Signaling Gastroenterology. 154: S-502. DOI: 10.1016/S0016-5085(18)31904-8 |
0.306 |
|
| 2017 |
Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, et al. Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice. Stem Cell Reports. PMID 28330618 DOI: 10.1016/J.Stemcr.2017.02.009 |
0.346 |
|
| 2017 |
Gao T, Evers BM. Colorectal cancer: A new innate immune sensor - functions from inside the colonic epithelium. Nature Reviews. Gastroenterology & Hepatology. PMID 28196986 DOI: 10.1038/Nrgastro.2017.10 |
0.318 |
|
| 2017 |
Xiong X, Wen YA, Mitov MI, C Oaks M, Miyamoto S, Gao T. PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells. Cell Death Discovery. 3: 16103. PMID 28179998 DOI: 10.1038/Cddiscovery.2016.103 |
0.404 |
|
| 2017 |
Wen YA, Xing X, Harris JW, Zaytseva YY, Mitov MI, Napier DL, Weiss HL, Mark Evers B, Gao T. Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer. Cell Death & Disease. 8: e2593. PMID 28151470 DOI: 10.1038/Cddis.2017.21 |
0.383 |
|
| 2017 |
Stevens PD, Wen Y, Gao T. Abstract B32: The tumor-suppressor function of Erbin in colon cancer Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-B32 |
0.472 |
|
| 2017 |
Zaytseva YY, Rychahou PG, Le A, Flight RM, Scott TL, Harris JW, Hodges S, Hallahan BJ, Napier DL, Liu J, Wang C, Sunkara M, Morris A, Kim JT, Arumugam ST, ... ... Gao T, et al. Abstract 452: Activation of Akt pathway and autophagy promotes resistance to FASN inhibition in colorectal cancer patient-derived xenograft models Cancer Research. 77: 452-452. DOI: 10.1158/1538-7445.Am2017-452 |
0.373 |
|
| 2016 |
Jafari N, Zheng Q, Li L, Li W, Qi L, Xiao J, Gao T, Huang C. S6K1-mediated phosphorylation regulates Phosphatidylinositol 4-phosphate 5-kinase type I γ degradation and cell invasion. The Journal of Biological Chemistry. PMID 27780861 DOI: 10.1074/Jbc.M116.742742 |
0.489 |
|
| 2016 |
Xiong X, Li X, Wen YA, Gao T. PH Domain Leucine-rich Repeat Protein Phosphatase Controls Cell Polarity by Negatively Regulating the Activity of Atypical Protein Kinase C. The Journal of Biological Chemistry. PMID 27760826 DOI: 10.1074/Jbc.M116.740639 |
0.463 |
|
| 2016 |
Smith AJ, Wen YA, Stevens PD, Liu J, Wang C, Gao T. PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells. Oncotarget. PMID 26760962 DOI: 10.18632/Oncotarget.6848 |
0.435 |
|
| 2016 |
Zaytseva Y, Harris J, Kim JT, Lee E, Weiss H, Gao T, Evers M. Abstract B54: The role of fatty acid synthase in regulation of autophagy in colorectal cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-B54 |
0.394 |
|
| 2016 |
Wen Y, Xiong X, Harris J, Zaytseva Y, Gao T. Abstract 4088: Adipocytes-mediated autophagy activation and metabolic reprogramming promotes colon cancer survival Cancer Research. 76: 4088-4088. DOI: 10.1158/1538-7445.Am2016-4088 |
0.383 |
|
| 2016 |
Zaytseva YY, Rychahou PG, Gao T, Lee EY, Weiss HL, Heuer TS, Kemble G, Evers BM. Abstract 1010: Evaluation of small-molecule FASN inhibitors in preclinical models of colorectal cancer Cancer Research. 76: 1010-1010. DOI: 10.1158/1538-7445.Am2016-1010 |
0.403 |
|
| 2016 |
Wolford T, Bradford EM, Gao T, Holley AK, Goretsky T, Izumi T, Barrett T. Sa1373 Mitochondrial Dysfunction Alters Progenitor Cell Metabolism and Impairs Notch Signaling Gastroenterology. 150: S298. DOI: 10.1016/S0016-5085(16)31044-7 |
0.322 |
|
| 2015 |
Goretsky T, Bradford EM, Ryu H, Tahir M, Moyer MP, Gao T, Li L, Barrett TA. A Cytosolic Multiprotein Complex containing p85α is required for β-catenin Activation in Colitis and Colitis-associated Cancer. The Journal of Biological Chemistry. PMID 26565021 DOI: 10.1074/Jbc.M115.669416 |
0.363 |
|
| 2015 |
Wen YA, Li X, Goretsky T, Weiss HL, Barrett TA, Gao T. Loss of PHLPP protects against colitis by inhibiting intestinal epithelial cell apoptosis. Biochimica Et Biophysica Acta. PMID 26187040 DOI: 10.1016/J.Bbadis.2015.07.012 |
0.354 |
|
| 2015 |
Zaytseva YY, Harris JW, Mitov MI, Kim JT, Butterfield DA, Lee EY, Weiss HL, Gao T, Evers BM. Increased expression of fatty acid synthase provides a survival advantage to colorectal cancer cells via upregulation of cellular respiration. Oncotarget. PMID 25970773 DOI: 10.18632/Oncotarget.3783 |
0.379 |
|
| 2015 |
Xiong X, Wen Y, Gao T. Abstract 1178: Loss of PHLPP expression promotes glycolysis in colon cancer cells Cancer Research. 75: 1178-1178. DOI: 10.1158/1538-7445.Am2015-1178 |
0.455 |
|
| 2015 |
Zaytseva YY, Harris JW, Kim JT, Gao T, Lee EY, Weiss HL, Evers BM. Abstract 1151: Overexpression of Fatty Acid Synthase is associated with inhibition of autophagy under conditions of metabolic stress in colorectal cancer cells Cancer Research. 75: 1151-1151. DOI: 10.1158/1538-7445.Am2015-1151 |
0.377 |
|
| 2015 |
Wen Y, Li X, Goretsky T, Barrett TA, Gao T. Abstract 1030: Loss of PHLPPs protects against colitis by inhibiting epithelial apoptosis through upregulating AKT activity Cancer Research. 75: 1030-1030. DOI: 10.1158/1538-7445.Am2015-1030 |
0.399 |
|
| 2015 |
Harris JW, Zaytseva Y, Wen Y, Xiaopeng X, Evers BM, Gao T. 876 Metformin Decreases Metabolic Activity, Cell Proliferation, and Protein Synthesis in Colon Cancer Cells Gastroenterology. 148: S-1124. DOI: 10.1016/S0016-5085(15)33831-2 |
0.394 |
|
| 2014 |
Jiang K, Liu Y, Fan J, Epperly G, Gao T, Jiang J, Jia J. Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 111: E4842-50. PMID 25349414 DOI: 10.1073/Pnas.1417147111 |
0.523 |
|
| 2014 |
Reyes G, Niederst M, Cohen-Katsenelson K, Stender JD, Kunkel MT, Chen M, Brognard J, Sierecki E, Gao T, Nowak DG, Trotman LC, Glass CK, Newton AC. Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output. Proceedings of the National Academy of Sciences of the United States of America. 111: E3957-65. PMID 25201979 DOI: 10.1073/Pnas.1404221111 |
0.783 |
|
| 2014 |
Li X, Stevens PD, Liu J, Yang H, Wang W, Wang C, Zeng Z, Schmidt MD, Yang M, Lee EY, Gao T. PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice. Gastroenterology. 146: 1301-12.e1-10. PMID 24530606 DOI: 10.1053/J.Gastro.2014.02.003 |
0.442 |
|
| 2014 |
Zaytseva YY, Elliott VA, Rychahou P, Mustain WC, Kim JT, Valentino J, Gao T, O'Connor KL, Neltner JM, Lee EY, Weiss HL, Evers BM. Cancer cell-associated fatty acid synthase activates endothelial cells and promotes angiogenesis in colorectal cancer. Carcinogenesis. 35: 1341-51. PMID 24510238 DOI: 10.1093/Carcin/Bgu042 |
0.375 |
|
| 2014 |
Li X, Gao T. MTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity Embo Reports. 15: 191-198. PMID 24375676 DOI: 10.1002/Embr.201338119 |
0.48 |
|
| 2014 |
Xiong X, li X, Gao T. Abstract 5288: PHLPP controls cell polarity by negatively regulating the activity of atypical PKC in colon cancer cells Cancer Research. 74: 5288-5288. DOI: 10.1158/1538-7445.Am2014-5288 |
0.44 |
|
| 2014 |
Zaytseva Y, Mitov M, Butterfield DA, Gao T, Evers BM. Abstract 4343: Inhibition of fatty acid synthase reduces mitochondrial respiration and addiction of colorectal cancer cells to glycolysis Cancer Research. 74: 4343-4343. DOI: 10.1158/1538-7445.Am2014-4343 |
0.354 |
|
| 2014 |
Wen Y, Xiong X, Gao T. Abstract 2431: Downregulation of PHLPP promotes glycolysis in colon cancer cells Cancer Research. 74: 2431-2431. DOI: 10.1158/1538-7445.Am2014-2431 |
0.473 |
|
| 2014 |
Zaytseva YY, Elliott V, Rychahou P, Mustain W, Kim JT, Valentino J, Gao T, O'Connor K, Neltner J, Weiss H, Evers BM. Abstract 1009: Tumor-specific expression of fatty acid synthase promotes angiogenesis in colorectal cancer Cancer Research. 74: 1009-1009. DOI: 10.1158/1538-7445.Am2014-1009 |
0.395 |
|
| 2014 |
Harris JW, Zaytseva Y, Evers BM, Gao T. Su1921 Metformin Alters Cellular Metabolism of Colon Cancer Cells Co-Cultured With Adipocytes Gastroenterology. 146: S-1053. DOI: 10.1016/S0016-5085(14)63842-7 |
0.316 |
|
| 2014 |
Li J, Song J, Weiss HL, Gao T, Townsend CM, Evers BM. Mo1783 Class III PI3K (HVPS34) Is Involved in AMPK-Regulated Neurotensin Secretion Independent of mTORC1 Signaling Gastroenterology. 146: S-659. DOI: 10.1016/S0016-5085(14)62399-4 |
0.425 |
|
| 2014 |
Song J, Li J, Weiss HL, Gao T, Townsend CM, Evers BM. 404 AMPK Positively Regulates Neurotensin Secretion Through Inhibition of mTORC1 Signaling Gastroenterology. 146: S-87. DOI: 10.1016/S0016-5085(14)60312-7 |
0.336 |
|
| 2013 |
Wen YA, Stevens PD, Gasser ML, Andrei R, Gao T. Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells. Molecular and Cellular Biology. 33: 4594-605. PMID 24061475 DOI: 10.1128/Mcb.00695-13 |
0.422 |
|
| 2013 |
Liu J, Stevens PD, Eshleman NE, Gao T. Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1). The Journal of Biological Chemistry. 288: 23225-33. PMID 23814053 DOI: 10.1074/Jbc.M113.492371 |
0.395 |
|
| 2013 |
Wen Y, Gao T. Abstract 5204: Downregulation of PHLLP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells. Cancer Research. 73: 5204-5204. DOI: 10.1158/1538-7445.Am2013-5204 |
0.422 |
|
| 2013 |
Li X, Stevens PD, Gao T. Abstract 4295: PHLPP suppresses epithelial-mesenchymal transition and cancer cell invasion by negatively regulating RAF1 activity. Cancer Research. 73: 4295-4295. DOI: 10.1158/1538-7445.Am2013-4295 |
0.519 |
|
| 2013 |
Stevens PD, Yang M, Gao T. Abstract 1478: The role of ERBIN in suppressing migration in colon cancer. Cancer Research. 73: 1478-1478. DOI: 10.1158/1538-7445.Am2013-1478 |
0.46 |
|
| 2012 |
Valentino JD, Elliott VA, Zaytseva YY, Rychahou PG, Mustain WC, Wang C, Gao T, Evers BM. Novel small interfering RNA cotargeting strategy as treatment for colorectal cancer. Surgery. 152: 277-85. PMID 22828149 DOI: 10.1016/J.Surg.2012.05.006 |
0.33 |
|
| 2012 |
Li J, Song J, Cassidy MG, Rychahou P, Starr ME, Liu J, Li X, Epperly G, Weiss HL, Townsend CM, Gao T, Evers BM. PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport. Molecular Endocrinology (Baltimore, Md.). 26: 1380-93. PMID 22700584 DOI: 10.1210/Me.2012-1024 |
0.437 |
|
| 2012 |
Gulhati P, Zaytseva YY, Valentino JD, Stevens PD, Kim JT, Sasazuki T, Shirasawa S, Lee EY, Weiss HL, Dong J, Gao T, Evers BM. Sorafenib enhances the therapeutic efficacy of rapamycin in colorectal cancers harboring oncogenic KRAS and PIK3CA. Carcinogenesis. 33: 1782-90. PMID 22696593 DOI: 10.1093/Carcin/Bgs203 |
0.46 |
|
| 2012 |
Li X, Stevens PD, Yang H, Gulhati P, Wang W, Evers BM, Gao T. The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. Oncogene. 32: 471-8. PMID 22391563 DOI: 10.1038/Onc.2012.66 |
0.499 |
|
| 2011 |
Liu J, Stevens PD, Li X, Schmidt MD, Gao T. PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth. Molecular and Cellular Biology. 31: 4917-27. PMID 21986499 DOI: 10.1128/Mcb.05799-11 |
0.537 |
|
| 2011 |
Ojeda L, Gao J, Hooten KG, Wang E, Thonhoff JR, Dunn TJ, Gao T, Wu P. Critical role of PI3K/Akt/GSK3β in motoneuron specification from human neural stem cells in response to FGF2 and EGF. Plos One. 6: e23414. PMID 21887250 DOI: 10.1371/Journal.Pone.0023414 |
0.347 |
|
| 2011 |
Li X, Yang H, Liu J, Schmidt MD, Gao T. Scribble-mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt. Embo Reports. 12: 818-24. PMID 21701506 DOI: 10.1038/Embor.2011.106 |
0.497 |
|
| 2011 |
Li J, Liu J, Song J, Wang X, Weiss HL, Townsend CM, Gao T, Evers BM. mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. American Journal of Physiology. Cell Physiology. 301: C213-26. PMID 21508335 DOI: 10.1152/ajpcell.00067.2011 |
0.514 |
|
| 2011 |
Patterson SJ, Han JM, Garcia R, Assi K, Gao T, O'Neill A, Newton AC, Levings MK. Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 5533-7. PMID 21498666 DOI: 10.4049/Jimmunol.1002126 |
0.789 |
|
| 2011 |
Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M, Lee EY, Weiss HL, O'Connor KL, Gao T, Evers BM. mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Research. 71: 3246-56. PMID 21430067 DOI: 10.1158/0008-5472.Can-10-4058 |
0.496 |
|
| 2011 |
Liu J, Stevens PD, Gao T. mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. The Journal of Biological Chemistry. 286: 6510-20. PMID 21177869 DOI: 10.1074/Jbc.M110.183087 |
0.489 |
|
| 2011 |
Liu J, Stevens P, Gao T. Abstract 3837: Protein Phosphatase PHLPP regulates protein translation and cell size through directly dephosphorylating p70 S6 kinase Cancer Research. 71: 3837-3837. DOI: 10.1158/1538-7445.Am2011-3837 |
0.571 |
|
| 2011 |
Gulhati P, Zaytseva Y, Weiss H, Gao T, Dong J, Evers BM. Abstract 1963: Combination of rapamycin with sorafenib as a therapeutic strategy against colorectal cancers with mutational activation ofKRASandPIK3CA Cancer Research. 71: 1963-1963. DOI: 10.1158/1538-7445.Am2011-1963 |
0.482 |
|
| 2011 |
Stevens PD, Li X, Gao T. The Role of PHLPP in Regulating Colon Cancer Cell Migration and Metastasis Gastroenterology. 140: S-822-S-823. DOI: 10.1016/S0016-5085(11)63407-0 |
0.388 |
|
| 2011 |
Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou P, Chen M, Lee EY, Weiss H, O'Connor KL, Gao T, Evers B. MTORC1 and mTORC2 Regulate EMT, Motility and Metastasis of Colorectal Cancer via RHOA and RAC1 Signaling Pathways Gastroenterology. 140: S-162. DOI: 10.1016/S0016-5085(11)60655-0 |
0.325 |
|
| 2010 |
Miyamoto S, Purcell NH, Smith JM, Gao T, Whittaker R, Huang K, Castillo R, Glembotski CC, Sussman MA, Newton AC, Brown JH. PHLPP-1 negatively regulates Akt activity and survival in the heart. Circulation Research. 107: 476-84. PMID 20576936 DOI: 10.1161/Circresaha.109.215020 |
0.654 |
|
| 2010 |
Larson Y, Liu J, Stevens PD, Li X, Li J, Evers BM, Gao T. Tuberous sclerosis complex 2 (TSC2) regulates cell migration and polarity through activation of CDC42 and RAC1. The Journal of Biological Chemistry. 285: 24987-98. PMID 20530489 DOI: 10.1074/Jbc.M109.096917 |
0.447 |
|
| 2010 |
Masubuchi S, Gao T, O'Neill A, Eckel-Mahan K, Newton AC, Sassone-Corsi P. Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock. Proceedings of the National Academy of Sciences of the United States of America. 107: 1642-7. PMID 20080691 DOI: 10.1073/Pnas.0910292107 |
0.759 |
|
| 2010 |
Liu J, Gao T. Abstract 4997: The expression PHLPP is regulated by the mTOR-P70S6K signaling pathway Cancer Research. 70: 4997-4997. DOI: 10.1158/1538-7445.Am10-4997 |
0.536 |
|
| 2010 |
Pat G, Bowen KA, Liu J, Li J, Qiu S, Weiss HL, Gao T, Evers BM. Abstract 427: Targeted inhibition of the mTOR complex components, RAPTOR and RICTOR, attenuates progression of colorectal cancer Cancer Research. 70: 427-427. DOI: 10.1158/1538-7445.Am10-427 |
0.463 |
|
| 2010 |
Gulhati P, Bowen K, Zaytseva K, Weiss H, Gao T, Dong J, Evers M. Abstract A41: Combined inhibition of mTOR and MAPK signaling attenuates the growth and progression of colorectal cancer Clinical Cancer Research. 16. DOI: 10.1158/1078-0432.Tcmusa10-A41 |
0.487 |
|
| 2010 |
Stevens PD, Liu J, Li X, Rychahou PG, Evers M, Gao T. W1746 The Role of Phlpp in Regulating Cell Migration and Metastasis Gastroenterology. 138: S-731. DOI: 10.1016/S0016-5085(10)63366-5 |
0.37 |
|
| 2010 |
Gulhati P, Bowen KA, Gao T, Dong J, Evers M. W1731 Dual Inhibition of mTOR and MAPK Signaling Attenuates the Growth and Progression of Colorectal Cancer Gastroenterology. 138: S-728-S-729. DOI: 10.1016/S0016-5085(10)63351-3 |
0.398 |
|
| 2010 |
Wang Q, Guo Z, Zhou Y, Li X, Gao T, Evers M. 956 NFAT5 Regulates Intestinal Cell Differentiation by Negatively Regulating AKT Gastroenterology. 138: S-139-S-140. DOI: 10.1016/S0016-5085(10)60640-3 |
0.418 |
|
| 2010 |
Patterson S, Garcia R, O'Neill A, Gao T, Newton A, Levings M. PHLPP Regulates the Development, Function and Molecular Signaling Pathways of T Regulatory Cells Clinical Immunology. 135: S6. DOI: 10.1016/J.Clim.2010.03.025 |
0.771 |
|
| 2009 |
Gulhati P, Cai Q, Li J, Liu J, Rychahou PG, Qiu S, Lee EY, Silva SR, Bowen KA, Gao T, Evers BM. Targeted inhibition of mammalian target of rapamycin signaling inhibits tumorigenesis of colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 7207-16. PMID 19934294 DOI: 10.1158/1078-0432.Ccr-09-1249 |
0.489 |
|
| 2009 |
Li X, Liu J, Gao T. beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt. Molecular and Cellular Biology. 29: 6192-205. PMID 19797085 DOI: 10.1128/Mcb.00681-09 |
0.408 |
|
| 2009 |
Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T. Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene. 28: 994-1004. PMID 19079341 DOI: 10.1038/Onc.2008.450 |
0.517 |
|
| 2009 |
Cai Q, Li J, Gao T, Xie J, Evers BM. Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity. The Journal of Biological Chemistry. 284: 2150-8. PMID 19015273 DOI: 10.1074/Jbc.M803235200 |
0.52 |
|
| 2009 |
Gulhati P, Cai Q, Bowen KA, Li J, Liu J, Qiu S, Gao T, Evers BM. Abstract B15: Targeted inhibition of mTOR signaling attenuates the growth and progression of colorectal cancer Cancer Research. 69. DOI: 10.1158/0008-5472.Fbcr09-B15 |
0.455 |
|
| 2009 |
Li J, Gao T, Liao M, Townsend CM, Evers B. W1583 Modulation of Neurotensin Secretion Through mTOR-Mediated AKT Inhibition in the Human Carcinoid Cell Line BON Gastroenterology. 136: A-696. DOI: 10.1016/S0016-5085(09)63208-X |
0.357 |
|
| 2009 |
Larson Y, Gao T. T1990 Loss of Tuberous Sclerosis Complex 2 (TSC2) Expression in Cancer Cells Inhibits Cell Migration By Suppressing RAC Activation Gastroenterology. 136: A-615-A-616. DOI: 10.1016/S0016-5085(09)62837-7 |
0.379 |
|
| 2009 |
Liu J, Gao T. S2000 The Expression Phlpp Is Regulated By the mTOR-P70s6k Signaling Pathway Gastroenterology. 136: A-310. DOI: 10.1016/S0016-5085(09)61416-5 |
0.304 |
|
| 2008 |
Gao T, Brognard J, Newton AC. The phosphatase PHLPP controls the cellular levels of protein kinase C. The Journal of Biological Chemistry. 283: 6300-11. PMID 18162466 DOI: 10.1074/Jbc.M707319200 |
0.774 |
|
| 2008 |
Cai Q, Li J, Gao T, Xie J, Evers B. M1617 PKCδ Is a Negative Regulator of the Hedgehog Pathway By Inhibition of GLI Protein Transcriptional Activity Gastroenterology. 134: A-383. DOI: 10.1016/S0016-5085(08)61787-4 |
0.391 |
|
| 2008 |
Cai Q, Li J, Gao T, Evers B. 617 The Mtor Complex 2 Regulates the Proliferation of Colon Cancer Cells Gastroenterology. 134: A-87. DOI: 10.1016/S0016-5085(08)60407-2 |
0.399 |
|
| 2008 |
Liu J, Evers B, Gao T. 613 Loss of Phlpp Expression in Colon Cancer: Role in Proliferation and Tumorigenesis Gastroenterology. 134: A-86. DOI: 10.1016/S0016-5085(08)60403-5 |
0.334 |
|
| 2008 |
Li J, Gao T, Townsend CM, Evers B. 384 ERK1c, a Novel Spliced Form of ERK1, Positively Regulates PGE2-Stimulated NT Secretion in the Human Endocrine Cell Line, BON Gastroenterology. 134: A-51. DOI: 10.1016/S0016-5085(08)60247-4 |
0.344 |
|
| 2007 |
Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. The Journal of Biological Chemistry. 282: 33776-87. PMID 17893151 DOI: 10.1074/Jbc.M703320200 |
0.767 |
|
| 2007 |
Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Molecular Cell. 25: 917-31. PMID 17386267 DOI: 10.1016/J.Molcel.2007.02.017 |
0.793 |
|
| 2007 |
Brognard J, Sierecki E, Gao T, Newton AC. Akt Signaling is Differentially Terminated by the Phosphatase PHLPP and a New Isoform, PHLPP2 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A619 |
0.74 |
|
| 2006 |
Gao T, Newton AC. Invariant Leu preceding turn motif phosphorylation site controls the interaction of protein kinase C with Hsp70 Journal of Biological Chemistry. 281: 32461-32468. PMID 16954220 DOI: 10.1074/Jbc.M604076200 |
0.633 |
|
| 2005 |
Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Molecular Cell. 18: 13-24. PMID 15808505 DOI: 10.1016/J.Molcel.2005.03.008 |
0.694 |
|
| 2002 |
Gao T, Newton AC. The turn motif is a phosphorylation switch that regulates the binding of Hsp70 to protein kinase C Journal of Biological Chemistry. 277: 31585-31592. PMID 12080070 DOI: 10.1074/Jbc.M204335200 |
0.639 |
|
| 2001 |
Sonnenburg ED, Gao T, Newton AC. The phosphoinositide-dependent kinase, PDK-1, phosphorylates conventional protein kinase C isozymes by a mechanism that is independent of phosphoinositide 3-kinase. The Journal of Biological Chemistry. 276: 45289-97. PMID 11579098 DOI: 10.1074/Jbc.M107416200 |
0.781 |
|
| 2001 |
Gao T, Toker A, Newton AC. The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, PDK-1. The Journal of Biological Chemistry. 276: 19588-96. PMID 11376011 DOI: 10.1074/Jbc.M101357200 |
0.655 |
|
| 1999 |
Bünemann M, Gerhardstein BL, Gao T, Hosey MM. Functional regulation of L-type calcium channels via protein kinase A-mediated phosphorylation of the beta(2) subunit. The Journal of Biological Chemistry. 274: 33851-4. PMID 10567342 DOI: 10.1074/Jbc.274.48.33851 |
0.36 |
|
| 1997 |
Gao T, Yatani A, Dell'Acqua ML, Sako H, Green SA, Dascal N, Scott JD, Hosey MM. cAMP-dependent regulation of cardiac L-type Ca2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron. 19: 185-96. PMID 9247274 DOI: 10.1016/S0896-6273(00)80358-X |
0.369 |
|
| 1997 |
Gao T, Puri TS, Gerhardstein BL, Chien AJ, Green RD, Hosey MM. Identification and subcellular localization of the subunits of l-type calcium channels and adenylyl cyclase in cardiac myocytes Journal of Biological Chemistry. 272: 19401-19407. PMID 9235939 DOI: 10.1074/Jbc.272.31.19401 |
0.312 |
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