Patrick Cras, MD PhD
|Neurology||University of Antwerp, Antwerpen, Vlaanderen, Belgium|
Area:dementia, Creutzfeldt-Jakob disease, cerebrospinal fluid, movement disorders and the neuropathology of neurodegenerative diseases
Presently Chairman of the Department of Neurology of the University Hospital of Antwerp and professor of neurology at the University of Antwerp, Patrick Cras trained as a medical doctor at the University of Antwerp (UA, 1983), as an research fellow in the Laboratory of Neuropathology at the Born Bunge Institute (1983-1985), later in the laboratory of anatomopathology at the University Hospital Antwerp, after which he obtained a specialty certification in neurology (1989). This was followed by a Fogarty Fellowship at Case Western Reserve University, Cleveland Ohio (1989-1991), were he worked on a doctoral thesis on the Pathogenesis of senile plaques in Alzheimer’s disease. Appointed as an attending physician at the Dept. of Neurology at the University Hospital (1991), he became associate professor of neurology in 1995. He (co-)authored more than 160 international peer reviewed articles and received 3 research awards (Specia, Divry and Belgian Geriatric Society). He is also the Chairman of the Ethics committee, Antwerp University Hospital (2000-present) and University of Antwerp (2008-present), a member of several committees of the High Council for Medicine (Hoge Gezondheidsraad), the National Bioethics Committee (Raadgevend Comité voor Bioethiek), chairman of the Neurology Committee of the Commission for Accreditation of Medical Doctors, President of the Belgian Society of Neuropathology. After having served as a faculty based ombudsman since 1984, Patrick Cras is the central ombudsman of the University of Antwerp since 2004.
Patrick Cras’s Specialties:
His research interests involve dementia, Creutzfeldt-Jakob disease, cerebrospinal fluid, movement disorders and the neuropathology of neurodegenerative diseases. He is also interested in the ethics of human experimentation, end-of-life decisions and research involving vulnerable subjects.
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|Martin S, Smolders S, Van den Haute C, et al. (2020) Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta Neuropathologica|
|Cacace R, Heeman B, Van Mossevelde S, et al. (2019) Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta Neuropathologica|
|Wauters E, Van Mossevelde S, Sleegers K, et al. (2018) Clinical variability and onset age modifiers in an extended Belgian GRN founder family. Neurobiology of Aging. 67: 84-94|
|Goossens J, Bjerke M, Van Mossevelde S, et al. (2018) Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration. Alzheimer's Research & Therapy. 10: 31|
|Sieben A, Van Mossevelde S, Wauters E, et al. (2018) Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family. Alzheimer's Research & Therapy. 10: 7|
|Goossens J, Bjerke M, Struyfs H, et al. (2017) No added diagnostic value of non-phosphorylated tau fraction (p-taurel) in CSF as a biomarker for differential dementia diagnosis. Alzheimer's Research & Therapy. 9: 49|
|Van Mossevelde S, van der Zee J, Gijselinck I, et al. (2017) Clinical Evidence of Disease Anticipation in Families Segregating a C9orf72 Repeat Expansion. Jama Neurology|
|Perrone F, Nguyen HP, Van Mossevelde S, et al. (2016) Investigating the role of ALS genes CHCHD10 and TUBA4A in Belgian FTD-ALS spectrum patients. Neurobiology of Aging|
|van der Zee J, Mariën P, Crols R, et al. (2016) Mutated CTSF in adult-onset neuronal ceroid lipofuscinosis and FTD. Neurology. Genetics. 2: e102|
|Somers C, Struyfs H, Goossens J, et al. (2016) A Decade of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Belgium. Journal of Alzheimer's Disease : Jad. 54: 383-95|