Sascha Weggen, Dr. rer. nat.

Neuropathology University of Duesseldof 
"Sascha Weggen"
Cross-listing: Neurotree

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Walter S, Jumpertz T, Hüttenrauch M, et al. (2018) The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease. Acta Neuropathologica
Hüttenrauch M, Ogorek I, Klafki H, et al. (2018) Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia. Acta Neuropathologica Communications. 6: 108
Storck SE, Hartz AMS, Bernard J, et al. (2018) The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM. Brain, Behavior, and Immunity
Lesuis SL, Weggen S, Baches S, et al. (2018) Targeting glucocorticoid receptors prevents the effects of early life stress on amyloid pathology and cognitive performance in APP/PS1 mice. Translational Psychiatry. 8: 53
Goel P, Jumpertz T, Tichá A, et al. (2018) Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors. Bioorganic & Medicinal Chemistry Letters
Goel P, Jumpertz T, Mikles DC, et al. (2017) Discovery and Biological Evaluation of Potent and Selective N-Methylene Saccharin-Derived Inhibitors for Rhomboid Intramembrane Proteases. Biochemistry
Wirths O, Walter S, Kraus I, et al. (2017) N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models. Alzheimer's Research & Therapy. 9: 80
Bradshaw NJ, Trossbach SV, Köber S, et al. (2017) Disrupted in Schizophrenia 1 regulates the processing of reelin in the perinatal cortex. Schizophrenia Research
Schönherr C, Bien J, Isbert S, et al. (2016) Generation of aggregation prone N-terminally truncated amyloid β peptides by meprin β depends on the sequence specificity at the cleavage site. Molecular Neurodegeneration. 11: 19
Antonios G, Borgers H, Richard BC, et al. (2015) Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X. Scientific Reports. 5: 17338
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