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Andrew P. Lieberman, MD PhD - Publications

Affiliations: 
Pathology University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Mechanisms of neurodegeneration in Kennedy's Disease.
Website:
http://www.pathology.med.umich.edu/faculty/Lieberman,A/index.html
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123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yuan T, Kumar S, Skinner M, Victor-Joseph R, Abuaita M, Keijer J, Zhang J, Kunkel TJ, Liu Y, Petrunak EM, Saunders TL, Lieberman AP, Stuckey JA, Neamati N, Al-Murshedi F, et al. variants from patients with mitochondrial disease are associated with reduced SIRT5 stability and activity, but not with neuropathology. Biorxiv : the Preprint Server For Biology. PMID 38105987 DOI: 10.1101/2023.12.06.570371  0.788
2023 Halseth TA, Correia AB, Schultz ML, Fawaz MV, Kuiper EQ, Kumaran P, Dorsey KH, Schuchman EH, Lieberman AP, Schwendeman A. Apolipoprotein-mimetic nanodiscs reduce lipid accumulation and improve liver function in acid sphingomyelinase deficiency. Nanomedicine : Nanotechnology, Biology, and Medicine. 102705. PMID 37633404 DOI: 10.1016/j.nano.2023.102705  0.706
2023 Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, ... ... Lieberman AP, et al. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies and nominates ancestry-specific loci , , and as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. Medrxiv : the Preprint Server For Health Sciences. PMID 37461624 DOI: 10.1101/2023.07.06.23292311  0.563
2023 Kunkel TJ, Townsend A, Sullivan KA, Merlet J, Schuchman EH, Jacobson DA, Lieberman AP. The cholesterol transporter NPC1 is essential for epigenetic regulation and maturation of oligodendrocyte lineage cells. Nature Communications. 14: 3964. PMID 37407594 DOI: 10.1038/s41467-023-39733-6  0.795
2023 Scalco R, Hamsafar Y, White CL, Schneider JA, Reichard RR, Prokop S, Perrin RJ, Nelson PT, Mooney S, Lieberman AP, Kukull WA, Kofler J, Keene CD, Kapasi A, Irwin DJ, et al. The status of digital pathology and associated infrastructure within Alzheimer's Disease Centers. Journal of Neuropathology and Experimental Neurology. PMID 36692179 DOI: 10.1093/jnen/nlac127  0.418
2022 Schultz ML, Schache KJ, Azaria RD, Kuiper EQ, Erwood S, Ivakine EA, Farhat NY, Porter FD, Pathmasiri KC, Cologna SM, Uhler MD, Lieberman AP. Species-specific differences in NPC1 protein trafficking govern therapeutic response in Niemann-Pick type C disease. Jci Insight. PMID 36301667 DOI: 10.1172/jci.insight.160308  0.752
2021 Liu EA, Mori E, Hamasaki F, Lieberman AP. TDP-43 proteinopathy occurs independently of autophagic substrate accumulation and underlies nuclear defects in Niemann-Pick C disease. Neuropathology and Applied Neurobiology. PMID 34048071 DOI: 10.1111/nan.12738  0.385
2021 Ilnytska O, Lai K, Gorshkov K, Schultz ML, Tran BN, Jeziorek M, Kunkel TJ, Azaria RD, McLoughlin HS, Waghalter M, Xu Y, Schlame M, Altan-Bonnet N, Zheng W, Lieberman AP, et al. Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage. The Journal of Biological Chemistry. 100813. PMID 34023384 DOI: 10.1016/j.jbc.2021.100813  0.798
2021 Colombo A, Dinkel L, Müller SA, Sebastian Monasor L, Schifferer M, Cantuti-Castelvetri L, König J, Vidatic L, Bremova-Ertl T, Lieberman AP, Hecimovic S, Simons M, Lichtenthaler SF, Strupp M, Schneider SA, et al. Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia. Nature Communications. 12: 1158. PMID 33627648 DOI: 10.1038/s41467-021-21428-5  0.35
2020 Pluciennik A, Liu Y, Molotsky E, Marsh GB, Ranxhi B, Arnold FJ, St-Cyr S, Davidson BL, Pourshafie N, Lieberman AP, Gu W, Todi SV, Merry DE. Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy. The Journal of Clinical Investigation. PMID 33170804 DOI: 10.1172/JCI134565  0.548
2020 Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, et al. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. Journal of Neuropathology and Experimental Neurology. PMID 33000167 DOI: 10.1093/jnen/nlaa109  0.422
2020 Liu EA, Schultz ML, Mochida C, Chung C, Paulson HL, Lieberman AP. Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain. Jci Insight. PMID 32931479 DOI: 10.1172/Jci.Insight.136676  0.794
2020 Nath SR, Lieberman ML, Yu Z, Marchioretti C, Jones ST, Danby ECE, Van Pelt KM, Sorarù G, Robins DM, Bates GP, Pennuto M, Lieberman AP. MEF2 impairment underlies skeletal muscle atrophy in polyglutamine disease. Acta Neuropathologica. PMID 32306066 DOI: 10.1007/s00401-020-02156-4  0.346
2019 Schultz ML, Fawaz MV, Azaria RD, Hollon TC, Liu EA, Kunkel TJ, Halseth TA, Krus KL, Ming R, Morin EE, McLoughlin HS, Bushart DD, Paulson HL, Shakkottai VG, Orringer DA, ... ... Lieberman AP, et al. Synthetic high-density lipoprotein nanoparticles for the treatment of Niemann-Pick diseases. Bmc Medicine. 17: 200. PMID 31711490 DOI: 10.1186/S12916-019-1423-5  0.769
2019 Davis AK, Pratt WB, Lieberman AP, Osawa Y. Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases. Cellular and Molecular Life Sciences : Cmls. PMID 31552448 DOI: 10.1007/S00018-019-03302-2  0.397
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Lieberman AP, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.56
2019 Eftekharzadeh B, Banduseela VC, Chiesa G, Martínez-Cristóbal P, Rauch JN, Nath SR, Schwarz DMC, Shao H, Marin-Argany M, Di Sanza C, Giorgetti E, Yu Z, Pieratelli R, Felli IC, Brun-Heath I, ... ... Lieberman AP, et al. Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nature Communications. 10: 3562. PMID 31395886 DOI: 10.1038/S41467-019-11594-Y  0.318
2019 Ravi B, Antonellis A, Sumner CJ, Lieberman AP. Genetic approaches to the treatment of inherited neuromuscular diseases. Human Molecular Genetics. PMID 31227836 DOI: 10.1093/Hmg/Ddz131  0.436
2019 LaLone V, Fawaz MV, Morales-Mercado J, Mourão MA, Snyder CS, Kim SY, Lieberman AP, Tuteja A, Mehta G, Standiford TJ, Raghavendran K, Shedden K, Schwendeman A, Stringer KA, Rosania GR. Inkjet-printed micro-calibration standards for ultraquantitative Raman spectral cytometry. The Analyst. PMID 31116195 DOI: 10.1039/C9An00500E  0.324
2019 McKay EC, Beck JS, Khoo SK, Dykema KJ, Cottingham SL, Winn ME, Paulson HL, Lieberman AP, Counts SE. Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia. Journal of Neuropathology and Experimental Neurology. 78: 436-452. PMID 30990880 DOI: 10.1093/jnen/nlz023  0.526
2019 Halievski K, Nath SR, Katsuno M, Adachi H, Sobue G, Breedlove SM, Lieberman AP, Jordan CL. Disease Affects Expression in Synaptic and Extrasynaptic Regions of Skeletal Muscle of Three SBMA Mouse Models. International Journal of Molecular Sciences. 20. PMID 30875922 DOI: 10.3390/ijms20061314  0.305
2019 Wang X, Becker K, Levine N, Zhang M, Lieberman AP, Moore DJ, Ma J. Pathogenic alpha-synuclein aggregates preferentially bind to mitochondria and affect cellular respiration. Acta Neuropathologica Communications. 7: 41. PMID 30871620 DOI: 10.1186/s40478-019-0696-4  0.329
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Lieberman AP, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.571
2018 Schultz ML, Krus KL, Kaushik S, Dang D, Chopra R, Qi L, Shakkottai VG, Cuervo AM, Lieberman AP. Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD. Nature Communications. 9: 3671. PMID 30202070 DOI: 10.1038/S41467-018-06115-2  0.765
2018 Petyuk VA, Chang R, Ramirez-Restrepo M, Beckmann ND, Henrion MYR, Piehowski PD, Zhu K, Wang S, Clarke J, Huentelman MJ, Xie F, Andreev V, Engel A, Guettoche T, Navarro L, ... ... Lieberman AP, et al. The human brainome: network analysis identifies HSPA2 as a novel Alzheimer's disease target. Brain : a Journal of Neurology. PMID 30137212 DOI: 10.1093/Brain/Awy215  0.401
2018 Lieberman AP, Shakkottai VG, Albin RL. Polyglutamine Repeats in Neurodegenerative Diseases. Annual Review of Pathology. PMID 30089230 DOI: 10.1146/Annurev-Pathmechdis-012418-012857  0.421
2018 Nath SR, Yu Z, Gipson TA, Marsh GB, Yoshidome E, Robins DM, Todi SV, Housman DE, Lieberman AP. Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. The Journal of Clinical Investigation. PMID 29809168 DOI: 10.1172/JCI99042  0.408
2018 Liu EA, Lieberman AP. The intersection of lysosomal and endoplasmic reticulum calcium with autophagy defects in lysosomal diseases. Neuroscience Letters. PMID 29704574 DOI: 10.1016/j.neulet.2018.04.049  0.373
2018 Lieberman AP. Spinal and bulbar muscular atrophy. Handbook of Clinical Neurology. 148: 625-632. PMID 29478604 DOI: 10.1016/B978-0-444-64076-5.00040-5  0.389
2018 Gurda BL, Bagel JH, Fisher SJ, Schultz ML, Lieberman AP, Hand P, Vite CH, Swain GP. LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss. Journal of Neuropathology and Experimental Neurology. PMID 29346563 DOI: 10.1093/Jnen/Nlx119  0.751
2018 Fawaz MV, Schultz M, Azaria R, Ming R, Lieberman A, Schwendeman A. Abstract 164: Synthetic High-Density Lipoprotein Cholesterol Scavengers for the Treatment of Niemann-Pick C Disease Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.164  0.723
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Lieberman AP, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.605
2017 Nath SR, Lieberman AP. The Ubiquitination, Disaggregation and Proteasomal Degradation Machineries in Polyglutamine Disease. Frontiers in Molecular Neuroscience. 10: 78. PMID 28381987 DOI: 10.3389/fnmol.2017.00078  0.468
2017 Milioto C, Malena A, Maino E, Polanco MJ, Marchioretti C, Borgia D, Pereira MG, Blaauw B, Lieberman AP, Venturini R, Plebani M, Sambataro F, Vergani L, Pegoraro E, Sorarù G, et al. Beta-agonist stimulation ameliorates the phenotype of spinal and bulbar muscular atrophy mice and patient-derived myotubes. Scientific Reports. 7: 41046. PMID 28117338 DOI: 10.1038/srep41046  0.368
2016 Polanco MJ, Parodi S, Piol D, Stack C, Chivet M, Contestabile A, Miranda HC, Lievens PM, Espinoza S, Jochum T, Rocchi A, Grunseich C, Gainetdinov RR, Cato AC, Lieberman AP, et al. Adenylyl cyclase activating polypeptide reduces phosphorylation and toxicity of the polyglutamine-expanded androgen receptor in spinobulbar muscular atrophy. Science Translational Medicine. 8: 370ra181. PMID 28003546 DOI: 10.1126/scitranslmed.aaf9526  0.701
2016 Giorgetti E, Yu Z, Chua JP, Shimamura R, Zhao L, Zhu F, Venneti S, Pennuto M, Guan Y, Hung G, Lieberman AP. Rescue of Metabolic Alterations in AR113Q Skeletal Muscle by Peripheral Androgen Receptor Gene Silencing. Cell Reports. 17: 125-36. PMID 27681426 DOI: 10.1016/J.Celrep.2016.08.084  0.692
2016 Giorgetti E, Lieberman AP. Polyglutamine androgen receptor-mediated neuromuscular disease. Cellular and Molecular Life Sciences : Cmls. PMID 27188284 DOI: 10.1007/s00018-016-2275-1  0.363
2016 Chung C, Elrick MJ, Dell'Orco JM, Qin ZS, Kalyana-Sundaram S, Chinnaiyan AM, Shakkottai VG, Lieberman AP. Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease. Plos Genetics. 12: e1006042. PMID 27152617 DOI: 10.1371/Journal.Pgen.1006042  0.747
2016 Schultz ML, Krus KL, Lieberman AP. Lysosome and endoplasmic reticulum quality control pathways in Niemann-pick type C disease. Brain Research. PMID 27026653 DOI: 10.1016/J.Brainres.2016.03.035  0.775
2016 Rocchi A, Milioto C, Parodi S, Armirotti A, Borgia D, Pellegrini M, Urciuolo A, Molon S, Morbidoni V, Marabita M, Romanello V, Gatto P, Blaauw B, Bonaldo P, Sambataro F, ... ... Lieberman AP, et al. Glycolytic-to-oxidative fiber-type switch and mTOR signaling activation are early-onset features of SBMA muscle modified by high-fat diet. Acta Neuropathologica. PMID 26971100 DOI: 10.1007/s00401-016-1550-4  0.353
2016 Chung C, Puthanveetil P, Ory DS, Lieberman AP. Genetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration. Human Molecular Genetics. PMID 26908626 DOI: 10.1093/Hmg/Ddw025  0.447
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Lieberman AP, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.615
2015 Rusmini P, Polanco MJ, Cristofani R, Cicardi ME, Meroni M, Galbiati M, Piccolella M, Messi E, Giorgetti E, Lieberman AP, Milioto C, Rocchi A, Aggarwal T, Pennuto M, Crippa V, et al. Aberrant Autophagic Response in The Muscle of A Knock-in Mouse Model of Spinal and Bulbar Muscular Atrophy. Scientific Reports. 5: 15174. PMID 26490709 DOI: 10.1038/srep15174  0.363
2015 Lieberman AP, Iniguez-Lluhi JA. Undoing SUMO aids polyQ AR. Oncotarget. 6: 32283-4. PMID 26431497 DOI: 10.18632/oncotarget.5862  0.469
2015 Praggastis M, Tortelli B, Zhang J, Fujiwara H, Sidhu R, Chacko A, Chen Z, Chung C, Lieberman AP, Sikora J, Davidson C, Walkley SU, Pipalia NH, Maxfield FR, Schaffer JE, et al. A Murine Niemann-Pick C1 I1061T Knock-In Model Recapitulates the Pathological Features of the Most Prevalent Human Disease Allele. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8091-106. PMID 26019327 DOI: 10.1523/Jneurosci.4173-14.2015  0.469
2015 Chua JP, Reddy SL, Yu Z, Giorgetti E, Montie HL, Mukherjee S, Higgins J, McEachin RC, Robins DM, Merry DE, Iñiguez-Lluhí JA, Lieberman AP. Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease. The Journal of Clinical Investigation. 125: 831-45. PMID 25607844 DOI: 10.1172/Jci73214  0.685
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Lieberman AP, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.449
2015 Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annual Review of Pharmacology and Toxicology. 55: 353-71. PMID 25292434 DOI: 10.1146/Annurev-Pharmtox-010814-124332  0.396
2014 Tallaksen-Greene SJ, Sadagurski M, Zeng L, Mauch R, Perkins M, Banduseela VC, Lieberman AP, Miller RA, Paulson HL, Albin RL. Differential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15658-68. PMID 25411494 DOI: 10.1523/JNEUROSCI.1830-14.2014  0.569
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Lieberman AP, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.598
2014 Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1405-13. PMID 24990484 DOI: 10.1177/1535370214539444  0.402
2014 Lieberman AP, Yu Z, Murray S, Peralta R, Low A, Guo S, Yu XX, Cortes CJ, Bennett CF, Monia BP, La Spada AR, Hung G. Peripheral androgen receptor gene suppression rescues disease in mouse models of spinal and bulbar muscular atrophy. Cell Reports. 7: 774-84. PMID 24746732 DOI: 10.1016/j.celrep.2014.02.008  0.598
2014 Renier KJ, Troxell-Smith SM, Johansen JA, Katsuno M, Adachi H, Sobue G, Chua JP, Sun Kim H, Lieberman AP, Breedlove SM, Jordan CL. Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy. Endocrinology. 155: 2624-34. PMID 24742193 DOI: 10.1210/En.2013-1756  0.696
2014 Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, ... ... Lieberman A, et al. TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathologica. 127: 407-18. PMID 24442578 DOI: 10.1007/S00401-013-1239-X  0.606
2014 Chua JP, Reddy SL, Merry DE, Adachi H, Katsuno M, Sobue G, Robins DM, Lieberman AP. Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy. Human Molecular Genetics. 23: 1376-86. PMID 24150846 DOI: 10.1093/Hmg/Ddt527  0.723
2014 Cologna SM, Cluzeau CV, Yanjanin NM, Blank PS, Dail MK, Siebel S, Toth CL, Wassif CA, Lieberman AP, Porter FD. Human and mouse neuroinflammation markers in Niemann-Pick disease, type C1. Journal of Inherited Metabolic Disease. 37: 83-92. PMID 23653225 DOI: 10.1007/S10545-013-9610-6  0.37
2013 Chua JP, Lieberman AP. Pathogenic mechanisms and therapeutic strategies in spinobulbar muscular atrophy. Cns & Neurological Disorders Drug Targets. 12: 1146-56. PMID 24040817 DOI: 10.2174/187152731131200124  0.714
2013 Griauzde J, Lieberman AP, McKean E, Sullivan S, Parmar HA. Radiology-pathology case report: isolated extranodal Rosai-Dorfman disease of the skull base. Clinical Imaging. 37: 1146-8. PMID 23932387 DOI: 10.1016/j.clinimag.2013.07.004  0.319
2013 Yu T, Lieberman AP. Npc1 acting in neurons and glia is essential for the formation and maintenance of CNS myelin. Plos Genetics. 9: e1003462. PMID 23593041 DOI: 10.1371/journal.pgen.1003462  0.39
2013 Meisler MH, Grant AE, Jones JM, Lenk GM, He F, Todd PK, Kamali M, Albin RL, Lieberman AP, Langenecker SA, McInnis MG. C9ORF72 expansion in a family with bipolar disorder. Bipolar Disorders. 15: 326-32. PMID 23551834 DOI: 10.1111/Bdi.12063  0.321
2013 Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nature Chemical Biology. 9: 112-8. PMID 23222885 DOI: 10.1038/Nchembio.1140  0.781
2013 Elrick MJ, Lieberman AP. Autophagic dysfunction in a lysosomal storage disorder due to impaired proteolysis. Autophagy. 9: 234-5. PMID 23086309 DOI: 10.4161/Auto.22501  0.73
2012 Fu R, Yanjanin NM, Elrick MJ, Ware C, Lieberman AP, Porter FD. Apolipoprotein E genotype and neurological disease onset in Niemann-Pick disease, type C1. American Journal of Medical Genetics. Part A. 158: 2775-80. PMID 23023945 DOI: 10.1002/Ajmg.A.35395  0.741
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Lieberman A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.588
2012 Elrick MJ, Yu T, Chung C, Lieberman AP. Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease. Human Molecular Genetics. 21: 4876-87. PMID 22872701 DOI: 10.1093/Hmg/Dds324  0.762
2012 Xiao H, Yu Z, Wu Y, Nan J, Merry DE, Sekiguchi JM, Ferguson DO, Lieberman AP, Dressler GR. A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability. Human Molecular Genetics. 21: 4225-36. PMID 22736030 DOI: 10.1093/Hmg/Dds246  0.383
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Lieberman AP, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801  0.33
2012 Lieberman AP, Puertollano R, Raben N, Slaugenhaupt S, Walkley SU, Ballabio A. Autophagy in lysosomal storage disorders. Autophagy. 8: 719-30. PMID 22647656 DOI: 10.4161/Auto.19469  0.396
2012 Andreev VP, Petyuk VA, Brewer HM, Karpievitch YV, Xie F, Clarke J, Camp D, Smith RD, Lieberman AP, Albin RL, Nawaz Z, El Hokayem J, Myers AJ. Label-free quantitative LC-MS proteomics of Alzheimer's disease and normally aged human brains. Journal of Proteome Research. 11: 3053-67. PMID 22559202 DOI: 10.1021/Pr3001546  0.348
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Lieberman AP, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/Hmg/Dds161  0.477
2012 Yu T, Chung C, Shen D, Xu H, Lieberman AP. Ryanodine receptor antagonists adapt NPC1 proteostasis to ameliorate lipid storage in Niemann-Pick type C disease fibroblasts. Human Molecular Genetics. 21: 3205-14. PMID 22505584 DOI: 10.1093/Hmg/Dds145  0.476
2012 Bakulski KM, Dolinoy DC, Sartor MA, Paulson HL, Konen JR, Lieberman AP, Albin RL, Hu H, Rozek LS. Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex. Journal of Alzheimer's Disease : Jad. 29: 571-88. PMID 22451312 DOI: 10.3233/Jad-2012-111223  0.537
2012 Shen D, Wang X, Li X, Zhang X, Yao Z, Dibble S, Dong XP, Yu T, Lieberman AP, Showalter HD, Xu H. Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release. Nature Communications. 3: 731. PMID 22415822 DOI: 10.1038/Ncomms1735  0.338
2011 Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP. Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice. Plos Genetics. 7: e1002321. PMID 22022281 DOI: 10.1371/Journal.Pgen.1002321  0.797
2011 Kemp MQ, Poort JL, Baqri RM, Lieberman AP, Breedlove SM, Miller KE, Jordan CL. Impaired motoneuronal retrograde transport in two models of SBMA implicates two sites of androgen action. Human Molecular Genetics. 20: 4475-90. PMID 21873607 DOI: 10.1093/Hmg/Ddr380  0.324
2011 Yu T, Shakkottai VG, Chung C, Lieberman AP. Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration. Human Molecular Genetics. 20: 4440-51. PMID 21856732 DOI: 10.1093/Hmg/Ddr372  0.453
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Lieberman AP, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801  0.372
2011 Johansen JA, Troxell-Smith SM, Yu Z, Mo K, Monks DA, Lieberman AP, Breedlove SM, Jordan CL. Prenatal flutamide enhances survival in a myogenic mouse model of spinal bulbar muscular atrophy. Neuro-Degenerative Diseases. 8: 25-34. PMID 20689246 DOI: 10.1159/000313682  0.384
2010 Mo K, Razak Z, Rao P, Yu Z, Adachi H, Katsuno M, Sobue G, Lieberman AP, Westwood JT, Monks DA. Microarray analysis of gene expression by skeletal muscle of three mouse models of Kennedy disease/spinal bulbar muscular atrophy. Plos One. 5: e12922. PMID 20886071 DOI: 10.1371/Journal.Pone.0012922  0.351
2010 Hernandez Lain A, Lieberman AP, Pfannl R, Hedley-Whyte ET. Nodular bilateral amygdala degeneration in demented individuals. Acta Neuropathologica. 120: 683-8. PMID 20838797 DOI: 10.1007/S00401-010-0745-3  0.347
2010 Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. The Journal of Biological Chemistry. 285: 15714-23. PMID 20348093 DOI: 10.1074/Jbc.M109.098806  0.765
2010 Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, ... ... Lieberman AP, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics. 42: 234-9. PMID 20154673 DOI: 10.1038/Ng.536  0.633
2010 Armstrong RA, Ellis W, Hamilton RL, Mackenzie IR, Hedreen J, Gearing M, Montine T, Vonsattel JP, Head E, Lieberman AP, Cairns NJ. Neuropathological heterogeneity in frontotemporal lobar degeneration with TDP-43 proteinopathy: a quantitative study of 94 cases using principal components analysis. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 227-39. PMID 20012109 DOI: 10.1007/S00702-009-0350-6  0.33
2010 Elrick MJ, Pacheco CD, Yu T, Dadgar N, Shakkottai VG, Ware C, Paulson HL, Lieberman AP. Conditional Niemann-Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration. Human Molecular Genetics. 19: 837-47. PMID 20007718 DOI: 10.1093/Hmg/Ddp552  0.797
2009 Yu Z, Wang AM, Robins DM, Lieberman AP. Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice. Disease Models & Mechanisms. 2: 500-7. PMID 19692580 DOI: 10.1242/dmm.003301  0.773
2009 Mukherjee S, Thomas M, Dadgar N, Lieberman AP, Iñiguez-Lluhí JA. Small ubiquitin-like modifier (SUMO) modification of the androgen receptor attenuates polyglutamine-mediated aggregation. The Journal of Biological Chemistry. 284: 21296-306. PMID 19497852 DOI: 10.1074/jbc.M109.011494  0.369
2009 Pacheco CD, Elrick MJ, Lieberman AP. Tau normal function influences Niemann-Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells. Autophagy. 5: 548-50. PMID 19332999 DOI: 10.4161/auto.5.4.8364  0.814
2009 Johansen JA, Yu Z, Mo K, Monks DA, Lieberman AP, Breedlove SM, Jordan CL. Recovery of function in a myogenic mouse model of spinal bulbar muscular atrophy. Neurobiology of Disease. 34: 113-20. PMID 19211034 DOI: 10.1016/j.nbd.2008.12.009  0.345
2009 Pacheco CD, Elrick MJ, Lieberman AP. Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Human Molecular Genetics. 18: 956-65. PMID 19074461 DOI: 10.1093/Hmg/Ddn423  0.814
2009 Lieberman A. 81. Autophagy in the pathogenesis of Niemann-Pick disease type C Molecular Genetics and Metabolism. 96: S29-S30. DOI: 10.1016/J.YMGME.2008.11.082  0.38
2008 Morishima Y, Wang AM, Yu Z, Pratt WB, Osawa Y, Lieberman AP. CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Human Molecular Genetics. 17: 3942-52. PMID 18784277 DOI: 10.1093/Hmg/Ddn296  0.777
2008 Pacheco CD, Lieberman AP. The pathogenesis of Niemann-Pick type C disease: a role for autophagy? Expert Reviews in Molecular Medicine. 10: e26. PMID 18782459 DOI: 10.1017/S146239940800080X  0.82
2008 Jordan CL, Lieberman AP. Spinal and bulbar muscular atrophy: a motoneuron or muscle disease? Current Opinion in Pharmacology. 8: 752-8. PMID 18775514 DOI: 10.1016/j.coph.2008.08.006  0.355
2008 Lieberman AP, Robins DM. The androgen receptor's CAG/glutamine tract in mouse models of neurological disease and cancer. Journal of Alzheimer's Disease : Jad. 14: 247-55. PMID 18560135 DOI: 10.3233/Jad-2008-14212  0.383
2008 Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, ... ... Lieberman A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 4: 151-75. PMID 18188003 DOI: 10.4161/Auto.5338  0.363
2007 Monks DA, Johansen JA, Mo K, Rao P, Eagleson B, Yu Z, Lieberman AP, Breedlove SM, Jordan CL. Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 18259-64. PMID 17984063 DOI: 10.1073/pnas.0705501104  0.397
2007 Hughes ED, Qu YY, Genik SJ, Lyons RH, Pacheco CD, Lieberman AP, Samuelson LC, Nasonkin IO, Camper SA, Van Keuren ML, Saunders TL. Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 18: 549-58. PMID 17828574 DOI: 10.1007/S00335-007-9054-0  0.763
2007 Pacheco CD, Lieberman AP. Lipid trafficking defects increase Beclin-1 and activate autophagy in Niemann-Pick type C disease. Autophagy. 3: 487-9. PMID 17611388 DOI: 10.4161/Auto.4586  0.827
2007 Pacheco CD, Kunkel R, Lieberman AP. Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects. Human Molecular Genetics. 16: 1495-503. PMID 17468177 DOI: 10.1093/hmg/ddm100  0.821
2006 Yu Z, Dadgar N, Albertelli M, Gruis K, Jordan C, Robins DM, Lieberman AP. Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model. The Journal of Clinical Investigation. 116: 2663-72. PMID 16981011 DOI: 10.1172/Jci28773  0.376
2006 Thomas M, Harrell JM, Morishima Y, Peng HM, Pratt WB, Lieberman AP. Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction. Human Molecular Genetics. 15: 1876-83. PMID 16644868 DOI: 10.1093/Hmg/Ddl110  0.4
2006 Yu Z, Dadgar N, Albertelli M, Scheller A, Albin RL, Robins DM, Lieberman AP. Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein. The American Journal of Pathology. 168: 195-204. PMID 16400023 DOI: 10.2353/Ajpath.2006.050619  0.476
2006 McKay EC, Beck JS, Winn M, Paulson HL, Lieberman AP, Counts SE. P3-208: THE OXYTOCIN RECEPTOR AND VASCULAR COGNITIVE IMPAIRMENT: POTENTIAL AS A NOVEL THERAPEUTIC TARGET Alzheimer's & Dementia. 14: P1148-P1149. DOI: 10.1016/j.jalz.2018.06.1567  0.487
2005 Thomas M, Yu Z, Dadgar N, Varambally S, Yu J, Chinnaiyan AM, Lieberman AP. The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor. The Journal of Biological Chemistry. 280: 21264-71. PMID 15799970 DOI: 10.1074/jbc.M500144200  0.409
2004 Moretti P, Lieberman AP, Wilde EA, Giordani BI, Kluin KJ, Koeppe RA, Minoshima S, Kuhl DE, Seltzer WK, Foster NL. Novel insertional presenilin 1 mutation causing Alzheimer disease with spastic paraparesis. Neurology. 62: 1865-8. PMID 15159497 DOI: 10.1212/01.Wnl.0000126447.91111.A1  0.36
2004 Chevalier-Larsen ES, O'Brien CJ, Wang H, Jenkins SC, Holder L, Lieberman AP, Merry DE. Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4778-86. PMID 15152038 DOI: 10.1523/JNEUROSCI.0808-04.2004  0.362
2004 Oravecz-Wilson KI, Kiel MJ, Li L, Rao DS, Saint-Dic D, Kumar PD, Provot MM, Hankenson KD, Reddy VN, Lieberman AP, Morrison SJ, Ross TS. Huntingtin Interacting Protein 1 mutations lead to abnormal hematopoiesis, spinal defects and cataracts. Human Molecular Genetics. 13: 851-67. PMID 14998932 DOI: 10.1093/Hmg/Ddh102  0.351
2004 Lieberman AP. SUMO, a ubiquitin-like modifier implicated in neurodegeneration. Experimental Neurology. 185: 204-7. PMID 14736501 DOI: 10.1016/j.expneurol.2003.10.009  0.331
2004 Thomas M, Dadgar N, Aphale A, Harrell JM, Kunkel R, Pratt WB, Lieberman AP. Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts. The Journal of Biological Chemistry. 279: 8389-95. PMID 14670946 DOI: 10.1074/Jbc.M311761200  0.38
2002 Lieberman AP, Harmison G, Strand AD, Olson JM, Fischbeck KH. Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor. Human Molecular Genetics. 11: 1967-76. PMID 12165558 DOI: 10.1093/Hmg/11.17.1967  0.582
2001 Puls I, Lieberman AP, Fischbeck KH. Impact of the human genome sequence on neurology and neuroscience. Archives of Neurology. 58: 1750-1. PMID 11708978 DOI: 10.1001/Archneur.58.11.1750  0.461
2001 Lieberman AP, Friedlich DL, Harmison G, Howell BW, Jordan CL, Breedlove SM, Fischbeck KH. Androgens regulate the mammalian homologues of invertebrate sex determination genes tra-2 and fox-1. Biochemical and Biophysical Research Communications. 282: 499-506. PMID 11401487 DOI: 10.1006/bbrc.2001.4617  0.542
2001 Lieberman AP, Puls I, Fischbeck KH. Mining the genome for causes and cures of neurological disease. Trends in Pharmacological Sciences. 22: 161-2. PMID 11282405 DOI: 10.1016/S0165-6147(00)01681-3  0.563
2000 Lieberman AP, Fischbeck KH. Triplet repeat expansion in neuromuscular disease. Muscle & Nerve. 23: 843-50. PMID 10842259 DOI: 10.1002/(SICI)1097-4598(200006)23:6<843::AID-MUS2>3.0.CO;2-8  0.607
1999 Lieberman AP, Trojanowski JQ, Leonard DG, Chen KL, Barnett JL, Leverenz JB, Bird TD, Robitaille Y, Malandrini A, Fischbeck KH. Ataxin 1 and ataxin 3 in neuronal intranuclear inclusion disease. Annals of Neurology. 46: 271-3. PMID 10443897 DOI: 10.1002/1531-8249(199908)46:2<271::Aid-Ana21>3.0.Co;2-M  0.645
1999 Fischbeck KH, Lieberman A, Bailey CK, Abel A, Merry DE. Androgen receptor mutation in Kennedy's disease. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 354: 1075-8. PMID 10434308 DOI: 10.1098/rstb.1999.0461  0.601
1999 Abraham S, Lieberman A, Pack A, Judy K, Wells G, Mourelatos Z. Case of the month: July 1998 - 21 year old man with new-onset seizures and a temporal lobe mass. Brain Pathology (Zurich, Switzerland). 9: 187-8. PMID 9989459  0.404
1998 Lieberman AP, Robitaille Y, Trojanowski JQ, Dickson DW, Fischbeck KH. Polyglutamine-containing aggregates in neuronal intranuclear inclusion disease. Lancet. 351: 884. PMID 9525376 DOI: 10.1016/S0140-6736(05)70296-8  0.646
1998 Brooks BP, Merry DE, Paulson HL, Lieberman AP, Kolson DL, Fischbeck KH. A cell culture model for androgen effects in motor neurons. Journal of Neurochemistry. 70: 1054-60. PMID 9489725 DOI: 10.1046/J.1471-4159.1998.70031054.X  0.64
1998 Lieberman AP, Trojanowski JQ, Lee VM, Balin BJ, Ding XS, Greenberg J, Morrison D, Reivich M, Grossman M. Cognitive, neuroimaging, and pathological studies in a patient with Pick's disease. Annals of Neurology. 43: 259-65. PMID 9485069 DOI: 10.1002/Ana.410430218  0.457
1998 Lieberman AP, Grossman RI, Lavi E. Case of the month: April 1997--a 32 year old man with mental status changes and a severe occipital headache. Brain Pathology (Zurich, Switzerland). 8: 229-30. PMID 9458178  0.468
1998 Mourelatos Z, Lieberman A, Salhany KE, Oberholtzer JC. PRIMARY LOW GRADE B-CELL LYMPHOMA OF THE DURA Journal of Neuropathology and Experimental Neurology. 57: 487. DOI: 10.1097/00005072-199805000-00084  0.497
1997 Galetta SL, Balcer LJ, Lieberman AP, Syed NA, Lee JM, Oberholtzer JC. Refractory giant cell arteritis with spinal cord infarction. Neurology. 49: 1720-3. PMID 9409378  0.658
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