John Q. Trojanowski, MD,Tufts University, PhD, Tufts University 1976 - Related publications

Affiliations: 
Pathology and Laboratory Medicine University of Pennsylvania, Philadelphia, PA, United States 
Area:
Neurodegenerative diseases
Website:
http://pathology.uphs.upenn.edu/Faculty/FacultyInfo.aspx?site=FacultyList&dept=Faculty&id=17800
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Saddiki H, Fayosse A, Cognat E, Sabia S, Engelborghs S, Wallon D, Alexopoulos P, Blennow K, Zetterberg H, Parnetti L, Zerr I, Hermann P, Gabelle A, Boada M, Orellana A, ... , et al. Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. Plos Medicine. 17: e1003289. PMID 32817639 DOI: 10.1371/journal.pmed.1003289   
2020 Muralidar S, Ambi SV, Sekaran S, Thirumalai D, Palaniappan B. Role of tau protein in Alzheimer's disease: The prime pathological player. International Journal of Biological Macromolecules. PMID 32784025 DOI: 10.1016/j.ijbiomac.2020.07.327   
2020 Kang SS, Ahn EH, Ye K. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & Molecular Medicine. PMID 32859953 DOI: 10.1038/s12276-020-00494-7   
2020 Ray WJ, Buggia-Prevot V. Novel Targets for Alzheimer's Disease: A View Beyond Amyloid. Annual Review of Medicine. PMID 32867590 DOI: 10.1146/annurev-med-052919-120219   
2020 Busche MA, Hyman BT. Synergy between amyloid-β and tau in Alzheimer's disease. Nature Neuroscience. PMID 32778792 DOI: 10.1038/s41593-020-0687-6   
2020 Zou K, Abdullah M, Michikawa M. Current Biomarkers for Alzheimer's Disease: From CSF to Blood. Journal of Personalized Medicine. 10. PMID 32806668 DOI: 10.3390/jpm10030085   
2020 De La-Rocque S, Moretto E, Butnaru I, Schiavo G. Knockin' on heaven's door: Molecular mechanisms of neuronal tau uptake. Journal of Neurochemistry. PMID 32770783 DOI: 10.1111/jnc.15144   
2020 Mold MJ, O'Farrell A, Morris B, Exley C. Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders. Journal of Alzheimer's Disease : Jad. PMID 32925074 DOI: 10.3233/JAD-200838   
2020 Yeung CHC, Lau KWD, Au Yeung SL, Schooling CM. Amyloid, tau and risk of Alzheimer's disease: a Mendelian randomization study. European Journal of Epidemiology. PMID 32929646 DOI: 10.1007/s10654-020-00683-8   
2020 Anu K R, Das S, Joseph A, Shenoy GG, Alex AT, Mudgal J. Neurodegenerative Pathways in Alzheimer's Disease: A Review. Current Neuropharmacology. PMID 32851951 DOI: 10.2174/1570159X18666200807130637   
2020 Keleman A, Wisch JK, Bollinger RM, Grant EA, Benzinger TL, Morris JC, Ances BM, Stark SL. Falls Associate with Neurodegenerative Changes in ATN Framework of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 32741815 DOI: 10.3233/JAD-200192   
2020 Triana-Baltzer G, Van Kolen K, Theunis C, Moughadam S, Slemmon R, Mercken M, Galpern W, Sun H, Kolb H. Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid. Journal of Alzheimer's Disease : Jad. PMID 32831201 DOI: 10.3233/JAD-200463   
2020 Reiss AB, Glass AD, Wisniewski T, Wolozin B, Gomolin IH, Pinkhasov A, De Leon J, Stecker MM. Alzheimer's disease: many failed trials, so where do we go from here? Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. 68: 1135-1140. PMID 32699179 DOI: 10.1136/jim-2020-001297   
2020 Guo T, Korman D, La Joie R, Shaw LM, Trojanowski JQ, Jagust WJ, Landau SM, . Normalization of CSF pTau measurement by Aβ improves its performance as a biomarker of Alzheimer's disease. Alzheimer's Research & Therapy. 12: 97. PMID 32799929 DOI: 10.1186/s13195-020-00665-8   
2020 Mishra J, Kumar B, Pandey M, Pottoo FH, Fayaz F, Khan FA, Sahoo PK. Carbon Nano Tubes: Novel drug delivery system in amelioration of Alzheimer's disease. Combinatorial Chemistry & High Throughput Screening. PMID 32957874 DOI: 10.2174/1386207323999200918112538   
2020 Van Kolen K, Malia TJ, Theunis C, Nanjunda R, Teplyakov A, Ernst R, Wu SJ, Luo J, Borgers M, Vandermeeren M, Bottelbergs A, Wintmolders C, Lacy E, Maurin H, Larsen P, et al. Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody. Journal of Alzheimer's Disease : Jad. PMID 32894244 DOI: 10.3233/JAD-200544   
2020 Kim HR, Lee T, Choi JK, Jeong Y, . Genetic variants beyond amyloid and tau associated with cognitive decline: A cohort study. Neurology. PMID 32938779 DOI: 10.1212/WNL.0000000000010724   
2020 Weigand AJ, Thomas KR, Bangen KJ, Eglit GML, Delano-Wood L, Gilbert PE, Brickman AM, Bondi MW, . APOE interacts with tau PET to influence memory independently of amyloid PET in older adults without dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32886451 DOI: 10.1002/alz.12173   
2020 Shi WY, Wang ZT, Sun FR, Ma YH, Xu W, Shen XN, Dong Q, Tan L, Yu JT, Yu Y, . High pulse pressure is a risk factor for prodromal Alzheimer's disease: a longitudinal study. Aging. 12. PMID 32960784 DOI: 10.18632/aging.103678   
2020 Gupta VB, Chitranshi N, Haan JD, Mirzaei M, You Y, Lim JK, Basavarajappa D, Godinez A, Di Angelantonio S, Sachdev P, Salekdeh GH, Bouwman F, Graham S, Gupta V. Retinal changes in Alzheimer's disease- integrated prospects of imaging, functional and molecular advances. Progress in Retinal and Eye Research. 100899. PMID 32890742 DOI: 10.1016/j.preteyeres.2020.100899   
2020 Liu M, Sui D, Dexheimer T, Hovde S, Deng X, Wang KW, Lin HL, Chien HT, Kweon HK, Kuo NS, Ayoub CA, Jimenez-Harrison D, Andrews PC, Kwok R, Bochar DA, et al. Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death. Molecular Neurobiology. PMID 32780352 DOI: 10.1007/s12035-020-02034-w   
2020 Liu M, Sui D, Dexheimer T, Hovde S, Deng X, Wang KW, Lin HL, Chien HT, Kweon HK, Kuo NS, Ayoub CA, Jimenez-Harrison D, Andrews PC, Kwok R, Bochar DA, et al. Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death. Mol Neurobiol. PMID 32780352 DOI: 10.1007/s12035-020-02034-w   
2020 Wang HF, Shen XN, Li JQ, Suckling J, Tan CC, Wang YJ, Feng L, Zhang C, Tan L, Dong Q, Touchon J, Gauthier S, Yu JT, . Clinical and biomarker trajectories in sporadic Alzheimer's disease: A longitudinal study. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12095. PMID 32793801 DOI: 10.1002/dad2.12095   
2020 Mukherjee J, Liang C, Patel KK, Lam PQ, Mondal R. Development and Evaluation of [ I]IPPI for Tau Imaging in Post-Mortem Human Alzheimer's Disease Brain. Synapse (New York, N.Y.). e22183. PMID 32722889 DOI: 10.1002/syn.22183   
2020 Cho H, Baek MS, Lee HS, Lee JH, Ryu YH, Lyoo CH. Principal components of tau positron emission tomography and longitudinal tau accumulation in Alzheimer's disease. Alzheimer's Research & Therapy. 12: 114. PMID 32967721 DOI: 10.1186/s13195-020-00685-4   
2020 Houben S, de Fisenne MA, Ando K, Vanden Dries V, Poncelet L, Yilmaz Z, Mansour S, De Decker R, Brion JP, Leroy K. Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice. Frontiers in Molecular Neuroscience. 13: 106. PMID 32765217 DOI: 10.3389/fnmol.2020.00106   
2020 Henríquez G, Gomez A, Guerrero ED, Narayan M. The Potential Role of Natural Polyphenols Against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical studies. Acs Chemical Neuroscience. PMID 32822152 DOI: 10.1021/acschemneuro.0c00381   
2020 Yan Y, Yan H, Teng Y, Wang Q, Yang P, Zhang L, Cheng H, Fu S. Long noncoding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease. The Journal of Gene Medicine. e3268. PMID 32891070 DOI: 10.1002/jgm.3268   
2020 Iaccarino L, La Joie R, Edwards L, Strom A, Schonhaut DR, Ossenkoppele R, Pham J, Mellinger T, Janabi M, Baker SL, Soleimani-Meigooni D, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD. Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer's Disease Continuum. Cerebral Cortex (New York, N.Y. : 1991). PMID 32808011 DOI: 10.1093/cercor/bhaa184   
2020 Guha S, Johnson GVW, Nehrke K. The Crosstalk Between Pathological Tau Phosphorylation and Mitochondrial Dysfunction as a Key to Understanding and Treating Alzheimer's Disease. Molecular Neurobiology. PMID 32851560 DOI: 10.1007/s12035-020-02084-0   
2020 Jamerlan A, An SSA. The influence of Aβ-dependent and independent pathways on TDP-43 proteinopathy in Alzheimer's disease: a possible connection to LATE-NC. Neurobiology of Aging. 95: 161-167. PMID 32814257 DOI: 10.1016/j.neurobiolaging.2020.06.020   
2020 Thomas DX, Bajaj S, McRae-McKee K, Hadjichrysanthou C, Anderson RM, Collinge J. Association of TDP-43 proteinopathy, cerebral amyloid angiopathy, and Lewy bodies with cognitive impairment in individuals with or without Alzheimer's disease neuropathology. Scientific Reports. 10: 14579. PMID 32883971 DOI: 10.1038/s41598-020-71305-2   
2020 Horie K, Barthélemy NR, Mallipeddi N, Li Y, Franklin EE, Perrin RJ, Bateman RJ, Sato C. Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain. Acta Neuropathologica Communications. 8: 149. PMID 32854776 DOI: 10.1186/s40478-020-01019-z   
2020 Wang L, Shi FX, Li N, Cao Y, Lei Y, Wang JZ, Tian Q, Zhou XW. AMPK Ameliorates Tau Acetylation and Memory Impairment Through Sirt1. Molecular Neurobiology. PMID 32820462 DOI: 10.1007/s12035-020-02079-x   
2020 Prendecki M, Kowalska M, Łagan-Jędrzejczyk U, Piekut T, Krokos A, Kozubski W, Dorszewska J. Genetic factors related to the immune system in subjects at risk of developing Alzheimer's disease. Journal of Integrative Neuroscience. 19: 359-371. PMID 32706201 DOI: 10.31083/j.jin.2020.02.110   
2020 Gu J, Xu W, Jin N, Li L, Zhou Y, Chu D, Gong CX, Iqbal K, Liu F. Truncation of tau selectively facilitates its pathological activities. The Journal of Biological Chemistry. PMID 32737201 DOI: 10.1074/jbc.RA120.012587   
2020 Plascencia-Villa G, Perry G. Status and future directions of clinical trials in Alzheimer's disease. International Review of Neurobiology. 154: 3-50. PMID 32739008 DOI: 10.1016/bs.irn.2020.03.022   
2020 Weitzman SA, Narasimhan S, He Z, Changolkar L, McBride JD, Zhang B, Schellenberg GD, Trojanowski JQ, Lee VMY. Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo. Journal of Neuropathology and Experimental Neurology. 79: 941-949. PMID 32838419 DOI: 10.1093/jnen/nlaa086   
2020 Palmqvist S, Janelidze S, Quiroz YT, Zetterberg H, Lopera F, Stomrud E, Su Y, Chen Y, Serrano GE, Leuzy A, Mattsson-Carlgren N, Strandberg O, Smith R, Villegas A, Sepulveda-Falla D, et al. Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders. Jama. PMID 32722745 DOI: 10.1001/jama.2020.12134   
2020 Hirschstein Z, Vanga GR, Wang G, Novakovic ZM, Grasso P. MA-[D-Leu-4]-OB3, a small molecule synthetic peptide leptin mimetic, improves episodic memory, and reduces serum levels of tumor necrosis factor-alpha and neurodegeneration in mouse models of Type 1 and Type 2 Diabetes Mellitus. Biochimica Et Biophysica Acta. General Subjects. 129697. PMID 32738275 DOI: 10.1016/j.bbagen.2020.129697   
2020 Lo Cascio F, Garcia S, Montalbano M, Puangmalai N, McAllen S, Pace A, Palumbo Piccionello A, Kayed R. Modulating Disease-Relevant Tau Oligomeric Strains by Small Molecules. The Journal of Biological Chemistry. PMID 32737202 DOI: 10.1074/jbc.RA120.014630   
2020 Spencer BE, Jennings RG, Fan CC, Brewer JB. Assessment of genetic risk for improved clinical-neuropathological correlations. Acta Neuropathologica Communications. 8: 160. PMID 32912321 DOI: 10.1186/s40478-020-01033-1   
2020 Abey A, Davies D, Goldsbury C, Buckland M, Valenzuela M, Duncan T. Distribution of Tau Hyperphosphorylation in Canine Dementia Resembles Early Alzheimer's Disease and other Tauopathies. Brain Pathology (Zurich, Switzerland). PMID 32810333 DOI: 10.1111/bpa.12893   
2020 Montalbano M, McAllen S, Puangmalai N, Sengupta U, Bhatt N, Johnson OD, Kharas MG, Kayed R. RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction. Nature Communications. 11: 4305. PMID 32855391 DOI: 10.1038/s41467-020-18022-6   
2020 Oh M, Oh SJ, Lee SJ, Oh JS, Roh JH, Chung SJ, Lee JH, Lee CS, Kim JS. Clinical Evaluation of 18F-PI-2620 as a Potent PET Radiotracer Imaging Tau Protein in Alzheimer Disease and Other Neurodegenerative Diseases Compared With 18F-THK-5351. Clinical Nuclear Medicine. PMID 32910050 DOI: 10.1097/RLU.0000000000003261   
2020 Bennett DA, Knopman DS. Extending AD biomarker studies into the Hispanic community. Neurology. PMID 32847949 DOI: 10.1212/WNL.0000000000010714   
2020 Rao SS, Portbury SD, Lago L, Bush AI, Adlard PA. The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy. Journal of Alzheimer's Disease : Jad. PMID 32741833 DOI: 10.3233/JAD-200551   
2020 Dai DL, Tropea TF, Robinson JL, Suh E, Hurtig H, Weintraub D, Van Deerlin V, Lee EB, Trojanowski JQ, Chen-Plotkin AS. ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies. Acta Neuropathologica. PMID 32749525 DOI: 10.1007/s00401-020-02199-7   
2020 Peña-Bautista C, Álvarez L, Durand T, Vigor C, Cuevas A, Baquero M, Vento M, Hervás D, Cháfer-Pericás C. Clinical Utility of Plasma Lipid Peroxidation Biomarkers in Alzheimer's Disease Differential Diagnosis. Antioxidants (Basel, Switzerland). 9. PMID 32707935 DOI: 10.3390/antiox9080649   
2020 Brosseron F, Kleemann K, Kolbe CC, Santarelli F, Castro-Gomez S, Tacik P, Latz E, Jessen F, Heneka MT. Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid binding protein 3 and ferritin to neurodegeneration and neuroinflammation. Journal of Neurochemistry. PMID 32894885 DOI: 10.1111/jnc.15175