John Q. Trojanowski, MD,Tufts University, PhD, Tufts University 1976 - Related publications

Pathology and Laboratory Medicine University of Pennsylvania, Philadelphia, PA, United States 
Neurodegenerative diseases
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Hashimoto M, Yamazaki A, Ohno A, Kimura T, Winblad B, Tjernberg LO. A Fragment of S38AA is a Novel Plasma Biomarker of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31524172 DOI: 10.3233/JAD-190700   
2019 Kumar D, Kumar P. Aβ, Tau, and α-Synuclein aggregation and integrated role of PARK2 in the regulation and clearance of toxic peptides. Neuropeptides. 101971. PMID 31540705 DOI: 10.1016/j.npep.2019.101971   
2019 Matsuda H, Shigemoto Y, Sato N. Neuroimaging of Alzheimer's disease: focus on amyloid and tau PET. Japanese Journal of Radiology. PMID 31493197 DOI: 10.1007/s11604-019-00867-7   
2019 Grimaldi A, Pediconi N, Oieni F, Pizzarelli R, Rosito M, Giubettini M, Santini T, Limatola C, Ruocco G, Ragozzino D, Di Angelantonio S. Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer's Disease Patients, Possible Biomarkers for Early Diagnosis. Frontiers in Neuroscience. 13: 925. PMID 31551688 DOI: 10.3389/fnins.2019.00925   
2019 Liu J, Li L. Targeting Autophagy for the Treatment of Alzheimer's Disease: Challenges and Opportunities. Frontiers in Molecular Neuroscience. 12: 203. PMID 31507373 DOI: 10.3389/fnmol.2019.00203   
2019 de Souza LC, Mariano LI, de Moraes RF, Caramelli P. Behavioral variant of frontotemporal dementia or frontal variant of Alzheimer's disease? A case study. Dementia & Neuropsychologia. 13: 356-360. PMID 31555411 DOI: 10.1590/1980-57642018dn13-030015   
2019 Gary C, Lam S, Hérard AS, Koch JE, Petit F, Gipchtein P, Sawiak SJ, Caillierez R, Eddarkaoui S, Colin M, Aujard F, Deslys JP, , Brouillet E, Buée L, et al. Encephalopathy induced by Alzheimer brain inoculation in a non-human primate. Acta Neuropathologica Communications. 7: 126. PMID 31481130 DOI: 10.1186/s40478-019-0771-x   
2019 Jack CR, Wiste HJ, Botha H, Weigand SD, Therneau TM, Knopman DS, Graff-Radford J, Jones DT, Ferman TJ, Boeve BF, Kantarci K, Lowe VJ, Vemuri P, Mielke MM, Fields JA, et al. The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes. Brain : a Journal of Neurology. PMID 31501889 DOI: 10.1093/brain/awz268   
2019 Ziontz J, Bilgel M, Shafer AT, Moghekar A, Elkins W, Helphrey J, Gomez G, June D, McDonald MA, Dannals RF, Azad BB, Ferrucci L, Wong DF, Resnick SM. Tau pathology in cognitively normal older adults. Alzheimer's & Dementia (Amsterdam, Netherlands). 11: 637-645. PMID 31517026 DOI: 10.1016/j.dadm.2019.07.007   
2019 Carandini T, Arighi A, Sacchi L, Fumagalli GG, Pietroboni AM, Ghezzi L, Colombi A, Scarioni M, Fenoglio C, De Riz MA, Marotta G, Scarpini E, Galimberti D. Testing the 2018 NIA-AA research framework in a retrospective large cohort of patients with cognitive impairment: from biological biomarkers to clinical syndromes. Alzheimer's Research & Therapy. 11: 84. PMID 31615545 DOI: 10.1186/s13195-019-0543-7   
2019 Long JM, Holtzman DM. Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. Cell. 179: 312-339. PMID 31564456 DOI: 10.1016/j.cell.2019.09.001   
2019 Sun MK, Alkon DL. Neuro-regeneration Therapeutic for Alzheimer's Dementia: Perspectives on Neurotrophic Activity. Trends in Pharmacological Sciences. 40: 655-668. PMID 31402121 DOI: 10.1016/   
2019 Wu T, Dejanovic B, Gandham VD, Gogineni A, Edmonds R, Schauer S, Srinivasan K, Huntley MA, Wang Y, Wang TM, Hedehus M, Barck KH, Stark M, Ngu H, Foreman O, et al. Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy. Cell Reports. 28: 2111-2123.e6. PMID 31433986 DOI: 10.1016/j.celrep.2019.07.060   
2019 Huseby CJ, Hoffman CN, Cooper GL, Cocuron JC, Alonso AP, Thomas SN, Yang AJ, Kuret J. Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31450505 DOI: 10.3233/JAD-190604   
2019 Ewers M, Franzmeier N, Suárez-Calvet M, Morenas-Rodriguez E, Caballero MAA, Kleinberger G, Piccio L, Cruchaga C, Deming Y, Dichgans M, Trojanowski JQ, Shaw LM, Weiner MW, Haass C, . Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science Translational Medicine. 11. PMID 31462511 DOI: 10.1126/scitranslmed.aav6221   
2019 Chandra A, Valkimadi PE, Pagano G, Cousins O, Dervenoulas G, Politis M, . Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment. Human Brain Mapping. PMID 31520513 DOI: 10.1002/hbm.24782   
2019 McRae-McKee K, Udeh-Momoh CT, Price G, Bajaj S, de Jager CA, Scott D, Hadjichrysanthou C, McNaughton E, Bracoud L, Ahmadi-Abhari S, de Wolf F, Anderson RM, Middleton LT, . Perspective: Clinical relevance of the dichotomous classification of Alzheimer's disease biomarkers: Should there be a "gray zone"? Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31564609 DOI: 10.1016/j.jalz.2019.07.010   
2019 Luo X, Li K, Zeng Q, Huang P, Jiaerken Y, Wang S, Shen Z, Xu X, Xu J, Wang C, Kong L, Zhou J, Zhang M. Application of T1-/T2-Weighted Ratio Mapping to Elucidate Intracortical Demyelination Process in the Alzheimer's Disease Continuum. Frontiers in Neuroscience. 13: 904. PMID 31551678 DOI: 10.3389/fnins.2019.00904   
2019 Verkhratsky A, Parpura V, Rodriguez-Arellano JJ, Zorec R. Astroglia in Alzheimer's Disease. Advances in Experimental Medicine and Biology. 1175: 273-324. PMID 31583592 DOI: 10.1007/978-981-13-9913-8_11   
2019 Gossye H, Van Broeckhoven C, Engelborghs S. The Use of Biomarkers and Genetic Screening to Diagnose Frontotemporal Dementia: Evidence and Clinical Implications. Frontiers in Neuroscience. 13: 757. PMID 31447625 DOI: 10.3389/fnins.2019.00757   
2019 Ahmad SS, Khan S, Kamal MA, Wasi U. The structure and function of α, β and γ-Secretase as therapeutic target enzymes into the development of Alzheimer's disease: A review. Cns & Neurological Disorders Drug Targets. PMID 31608840 DOI: 10.2174/1871527318666191011145941   
2019 Baghel V, Tripathi M, Parida G, Gupta R, Yadav S, Kumar P, Dey AB, Damle NA, Kumar R, Bal C. In Vivo Assessment of Tau Deposition in Alzheimer Disease and Assessing Its Relationship to Regional Brain Glucose Metabolism and Cognition. Clinical Nuclear Medicine. PMID 31584490 DOI: 10.1097/RLU.0000000000002791   
2019 Park SY, Seo J, Chun YS. Targeted Downregulation of Ameliorates Tau-engendered Defects in . Journal of Korean Medical Science. 34: e225. PMID 31436053 DOI: 10.3346/jkms.2019.34.e225   
2019 Li Y, Yao Z, Yu Y, Fu Y, Zou Y, Hu B, . The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory. Frontiers in Aging Neuroscience. 11: 208. PMID 31440157 DOI: 10.3389/fnagi.2019.00208   
2019 Li Y, Yao Z, Yu Y, Fu Y, Zou Y, Hu B, . The Influence of Cerebrospinal Fluid Abnormalities and APOE 4 on PHF-Tau Protein: Evidence From Voxel Analysis and Graph Theory. Frontiers in Aging Neuroscience. 11: 208. PMID 31440157 DOI: 10.3389/fnagi.2019.00208   
2019 Charil A, Shcherbinin S, Southekal S, Devous MD, Mintun M, Murray ME, Miller BB, Schwarz AJ. Tau Subtypes of Alzheimer's Disease Determined in vivo Using Flortaucipir PET Imaging. Journal of Alzheimer's Disease : Jad. PMID 31476153 DOI: 10.3233/JAD-190264   
2019 Jeon SG, Song EJ, Lee D, Park J, Nam Y, Kim JI, Moon M. Traditional Oriental Medicines and Alzheimer's Disease. Aging and Disease. 10: 307-328. PMID 31435482 DOI: 10.14336/AD.2018.0328   
2019 Caruso A, Nicoletti F, Gaetano A, Scaccianoce S. Risk Factors for Alzheimer's Disease: Focus on Stress. Frontiers in Pharmacology. 10: 976. PMID 31551781 DOI: 10.3389/fphar.2019.00976   
2019 Ajit D, Trzeciakiewicz H, Tseng JH, Wander CM, Chen Y, Ajit A, King DP, Cohen TJ. A unique tau conformation generated by an acetylation-mimic substitution modulates P301S-dependent tau pathology and hyperphosphorylation. The Journal of Biological Chemistry. PMID 31543505 DOI: 10.1074/jbc.RA119.009674   
2019 Xicota L, Ichou F, Lejeune FX, Colsch B, Tenenhaus A, Leroy I, Fontaine G, Lhomme M, Bertin H, Habert MO, Epelbaum S, Dubois B, Mochel F, Potier MC, . Multi-omics signature of brain amyloid deposition in asymptomatic individuals at-risk for Alzheimer's disease: The INSIGHT-preAD study. Ebiomedicine. PMID 31492558 DOI: 10.1016/j.ebiom.2019.08.051   
2019 Jang H, Kim HJ, Park S, Park YH, Choe Y, Cho H, Lyoo CH, Yoon U, Lee JS, Kim Y, Kim SJ, Kim JP, Jung YH, Ryu YH, Choi JY, et al. Application of an amyloid and tau classification system in subcortical vascular cognitive impairment patients. European Journal of Nuclear Medicine and Molecular Imaging. PMID 31471715 DOI: 10.1007/s00259-019-04498-y   
2019 Myers A, McGonigle P. Overview of Transgenic Mouse Models for Alzheimer's Disease. Current Protocols in Neuroscience. 89: e81. PMID 31532917 DOI: 10.1002/cpns.81   
2019 Polis B, Gurevich V, Assa M, Samson AO. Norvaline Restores the BBB Integrity in a Mouse Model of Alzheimer's Disease. International Journal of Molecular Sciences. 20. PMID 31540372 DOI: 10.3390/ijms20184616   
2019 Poncelet L, Ando K, Vergara C, Mansour S, Suain V, Yilmaz Z, Reygel A, Gilissen E, Brion JP, Leroy K. A 4R tauopathy develops without amyloid deposits in aged cat brains. Neurobiology of Aging. 81: 200-212. PMID 31306814 DOI: 10.1016/j.neurobiolaging.2019.05.024   
2019 Williams G, Gatt A, Clarke E, Corcoran J, Doherty P, Chambers D, Ballard C. Drug repurposing for Alzheimer's disease based on transcriptional profiling of human iPSC-derived cortical neurons. Translational Psychiatry. 9: 220. PMID 31492831 DOI: 10.1038/s41398-019-0555-x   
2019 Bertoux M, Lagarde J, Corlier F, Hamelin L, Mangin JF, Colliot O, Chupin M, Braskie MN, Thompson PM, Bottlaender M, Sarazin M. Sulcal morphology in Alzheimer's disease: an effective marker of diagnosis and cognition. Neurobiology of Aging. 84: 41-49. PMID 31491594 DOI: 10.1016/j.neurobiolaging.2019.07.015   
2019 Pietronigro E, Zenaro E, Bianca VD, Dusi S, Terrabuio E, Iannoto G, Slanzi A, Ghasemi S, Nagarajan R, Piacentino G, Tosadori G, Rossi B, Constantin G. Blockade of α4 integrins reduces leukocyte-endothelial interactions in cerebral vessels and improves memory in a mouse model of Alzheimer's disease. Scientific Reports. 9: 12055. PMID 31427644 DOI: 10.1038/s41598-019-48538-x   
2019 Wang S, Cho YK. Yeast surface display of full-length human microtubule-associated protein tau. Biotechnology Progress. PMID 31581367 DOI: 10.1002/btpr.2920   
2019 Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau. Elife. 8. PMID 31612856 DOI: 10.7554/eLife.46924   
2019 Giorgi FS, Saccaro LF, Galgani A, Busceti CL, Biagioni F, Frati A, Fornai F. The role of Locus Coeruleus in neuroinflammation occurring in Alzheimer's disease. Brain Research Bulletin. 153: 47-58. PMID 31419539 DOI: 10.1016/j.brainresbull.2019.08.007   
2019 Nakamura M, Shiozawa S, Tsuboi D, Amano M, Watanabe H, Maeda S, Kimura T, Yoshimatsu S, Kisa F, Karch CM, Miyasaka T, Takashima A, Sahara N, Hisanaga SI, Ikeuchi T, et al. Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCs. Stem Cell Reports. PMID 31543469 DOI: 10.1016/j.stemcr.2019.08.011   
2019 Yanagawa T, Takao M, Yasuda M, Kamide T, Sato H, Suzuki K, Ikeda T, Kikkawa Y, Kurita H. Clinical and neuropathologic analysis of intracerebral hemorrhage in patients with cerebral amyloid angiopathy. Clinical Neurology and Neurosurgery. 176: 110-115. PMID 30554091 DOI: 10.1016/j.clineuro.2018.11.020   
2019 Zhu Y, Peng L, Hu J, Chen Y, Chen F. Current anti-Alzheimer's disease effect of natural products and their principal targets. Journal of Integrative Neuroscience. 18: 327-339. PMID 31601083 DOI: 10.31083/j.jin.2019.03.1105   
2019 Park JC, Han SH, Lee H, Jeong H, Byun MS, Bae J, Kim H, Young Lee D, Yi D, Shin SA, Kim YK, Hwang D, Lee SW, Mook-Jung I. Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer's disease. Progress in Neurobiology. 101690. PMID 31605717 DOI: 10.1016/j.pneurobio.2019.101690   
2019 Kisby B, Jarrell JT, Agar ME, Cohen DS, Rosin ER, Cahill CM, Rogers JT, Huang X. Alzheimer's Disease and Its Potential Alternative Therapeutics. Journal of Alzheimer's Disease & Parkinsonism. 9. PMID 31588368 DOI: 10.4172/2161-0460.1000477   
2019 Katsumoto A, Takeuchi H, Tanaka F. Tau Pathology in Chronic Traumatic Encephalopathy and Alzheimer's Disease: Similarities and Differences. Frontiers in Neurology. 10: 980. PMID 31551922 DOI: 10.3389/fneur.2019.00980   
2019 Yagi T, Kanekiyo M, Ito J, Ihara R, Suzuki K, Iwata A, Iwatsubo T, Aoshima K, , . Identification of prognostic factors to predict cognitive decline of patients with early Alzheimer's disease in the Japanese Alzheimer's Disease Neuroimaging Initiative study. Alzheimer's & Dementia (New York, N. Y.). 5: 364-373. PMID 31440579 DOI: 10.1016/j.trci.2019.06.004   
2019 Morozova V, Cohen LS, Makki AE, Shur A, Pilar G, El Idrissi A, Alonso AD. Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes. Frontiers in Cellular Neuroscience. 13: 403. PMID 31555098 DOI: 10.3389/fncel.2019.00403   
2019 Nolan A, De Paula Franca Resende E, Petersen C, Neylan K, Spina S, Huang E, Seeley W, Miller Z, Grinberg LT. Astrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations. Journal of Neuropathology and Experimental Neurology. PMID 31626288 DOI: 10.1093/jnen/nlz094   
2019 Mc Ardle R, Galna B, Donaghy P, Thomas A, Rochester L. Do Alzheimer's and Lewy body disease have discrete pathological signatures of gait? Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31548122 DOI: 10.1016/j.jalz.2019.06.4953