cached image

Edward H. Koo, MD - Publications

Neuroscience University of California, San Diego, La Jolla, CA 

141 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Huang R, Nikooyan AA, Xu B, Joseph MS, Damavandi HG, von Trotha N, Li L, Bhattarai A, Zadeh D, Seo Y, Liu X, Truong PA, Koo EH, Leiter JC, Lu DC. Machine learning classifies predictive kinematic features in a mouse model of neurodegeneration. Scientific Reports. 11: 3950. PMID 33597593 DOI: 10.1038/s41598-021-82694-3  0.68
2017 Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, et al. Short Aβ peptides attenuate Aβ42 toxicity in vivo. The Journal of Experimental Medicine. PMID 29208777 DOI: 10.1084/Jem.20170600  0.56
2017 Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, et al. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Reports. 21: 2614-2627. PMID 29186695 DOI: 10.1016/J.Celrep.2017.11.009  0.92
2017 Eggert S, Gonzalez AC, Thomas C, Schilling S, Schwarz SM, Tischer C, Adam V, Strecker P, Schmidt V, Willnow TE, Hermey G, Pietrzik CU, Koo EH, Kins S. Dimerization leads to changes in APP (amyloid precursor protein) trafficking mediated by LRP1 and SorLA. Cellular and Molecular Life Sciences : Cmls. PMID 28799085 DOI: 10.1007/S00018-017-2625-7  0.68
2017 Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, Strecker P, Korte M, Koo EH, Müller U, Kins S, Eggert S. APLP1 is a synaptic cell adhesion molecule, supporting maintenance of dendritic spines and basal synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28450540 DOI: 10.1523/Jneurosci.1875-16.2017  0.52
2016 Park SA, Chevallier N, Tejwani K, Hung MM, Maruyama H, Golde TE, Koo EH. Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice. Biochemical and Biophysical Research Communications. PMID 27425247 DOI: 10.1016/J.Bbrc.2016.07.015  0.68
2015 Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). Plos One. 10: e0144758. PMID 26678856 DOI: 10.1371/Journal.Pone.0144758  0.92
2015 Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nature Neuroscience. PMID 26642089 DOI: 10.1038/Nn.4188  0.8
2015 Ling IF, Golde TE, Galasko DR, Koo EH. Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Alzheimer's Research & Therapy. 7: 55. PMID 26244059 DOI: 10.1186/S13195-015-0137-Y  0.92
2015 Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Molecular Neurodegeneration. 10: 29. PMID 26169917 DOI: 10.1186/S13024-015-0021-Z  0.92
2015 Nhan HS, Chiang K, Koo EH. The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathologica. 129: 1-19. PMID 25287911 DOI: 10.1007/S00401-014-1347-2  0.92
2015 Lakshmana MK, Hayes CD, Bennett SP, Bianchi E, Reddy KM, Koo EH, Kang DE. Errata: The article, "Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain," (The FASEB Journal (2012) 26, (2072-2083) DOI:10.1096/fj.11-196709) Faseb Journal. 29: 1124. DOI: 10.1096/fj.11-196709ERR  0.92
2014 Jung JI, Premraj S, Cruz PE, Ladd TB, Kwak Y, Koo EH, Felsenstein KM, Golde TE, Ran Y. Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity. Plos One. 9: e111553. PMID 25350374 DOI: 10.1371/Journal.Pone.0111553  0.56
2014 Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. Jama Neurology. 71: 1481-9. PMID 25285942 DOI: 10.1001/Jamaneurol.2014.2482  0.8
2014 Jung JI, Ran Y, Cruz PE, Rosario AM, Ladd TB, Kukar TL, Koo EH, Felsenstein KM, Golde TE. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry. 53: 1947-57. PMID 24620716 DOI: 10.1021/Bi401521T  0.92
2014 Wilke SA, Raam T, Antonios JK, Bushong EA, Koo EH, Ellisman MH, Ghosh A. Specific disruption of hippocampal mossy fiber synapses in a mouse model of familial Alzheimer's disease. Plos One. 9: e84349. PMID 24454724 DOI: 10.1371/Journal.Pone.0084349  0.92
2013 Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 15596-602. PMID 24068826 DOI: 10.1523/Jneurosci.5195-12.2013  0.92
2013 Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S. Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron. 79: 447-60. PMID 23931995 DOI: 10.1016/J.Neuron.2013.05.035  0.92
2013 Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. γ-Secretase inhibitors and modulators. Biochimica Et Biophysica Acta. 1828: 2898-907. PMID 23791707 DOI: 10.1016/J.Bbamem.2013.06.005  0.92
2013 Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. Steroids as γ-secretase modulators. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3775-85. PMID 23716494 DOI: 10.1096/Fj.12-225649  0.92
2013 Hilal S, Ikram MK, Saini M, Tan CS, Catindig JA, Dong YH, Lim LB, Ting EY, Koo EH, Cheung CY, Qiu A, Wong TY, Chen CL, Venketasubramanian N. Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 686-92. PMID 23385846 DOI: 10.1136/Jnnp-2012-304080  0.92
2012 Park SS, Jung HJ, Kim YJ, Park TK, Kim C, Choi H, Mook-Jung IH, Koo EH, Park SA. Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity. Journal of Neurochemistry. 123: 856-65. PMID 23020770 DOI: 10.1111/Jnc.12032  0.36
2012 Tyan SH, Shih AY, Walsh JJ, Maruyama H, Sarsoza F, Ku L, Eggert S, Hof PR, Koo EH, Dickstein DL. Amyloid precursor protein (APP) regulates synaptic structure and function. Molecular and Cellular Neurosciences. 51: 43-52. PMID 22884903 DOI: 10.1016/J.Mcn.2012.07.009  0.92
2012 Woo JA, Jung AR, Lakshmana MK, Bedrossian A, Lim Y, Bu JH, Park SA, Koo EH, Mook-Jung I, Kang DE. Pivotal role of the RanBP9-cofilin pathway in Aβ-induced apoptosis and neurodegeneration. Cell Death and Differentiation. 19: 1413-23. PMID 22361682 DOI: 10.1016/J.Jalz.2012.05.1673  0.92
2012 Midthune B, Tyan SH, Walsh JJ, Sarsoza F, Eggert S, Hof PR, Dickstein DL, Koo EH. Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Molecular and Cellular Neurosciences. 49: 448-55. PMID 22353605 DOI: 10.1016/J.Mcn.2012.02.001  0.92
2012 Tang Y, Scott DA, Das U, Edland SD, Radomski K, Koo EH, Roy S. Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic (Copenhagen, Denmark). 13: 681-93. PMID 22309053 DOI: 10.1111/J.1600-0854.2012.01340.X  0.92
2012 Lakshmana MK, Hayes CD, Bennett SP, Bianchi E, Reddy KM, Koo EH, Kang DE. Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 2072-83. PMID 22294787 DOI: 10.1096/Fj.11-196709  0.92
2012 Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, ... Koo EH, et al. Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 482: 216-20. PMID 22278060 DOI: 10.1038/Nature10821  0.92
2011 Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH. Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. The Journal of Biological Chemistry. 286: 39794-803. PMID 21868380 DOI: 10.1074/Jbc.M111.277228  0.92
2011 Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, et al. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. The Journal of Biological Chemistry. 286: 39804-12. PMID 21868378 DOI: 10.1074/Jbc.M111.274696  0.92
2011 Zheng H, Koo EH. Biology and pathophysiology of the amyloid precursor protein. Molecular Neurodegeneration. 6: 27. PMID 21527012 DOI: 10.1186/1750-1326-6-27  0.44
2011 Golde TE, Schneider LS, Koo EH. Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron. 69: 203-13. PMID 21262461 DOI: 10.1016/J.Neuron.2011.01.002  0.92
2010 Lessard CB, Wagner SL, Koo EH. And four equals one: presenilin takes the gamma-secretase role by itself. Proceedings of the National Academy of Sciences of the United States of America. 107: 21236-7. PMID 21135249 DOI: 10.1073/Pnas.1016284108  0.92
2010 Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nature Communications. 1: 130. PMID 21119643 DOI: 10.1038/Ncomms1129  0.92
2010 Lakshmana MK, Chung JY, Wickramarachchi S, Tak E, Bianchi E, Koo EH, Kang DE. A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 119-27. PMID 19729516 DOI: 10.1096/Fj.09-136457  0.92
2010 Tyan S, Midthune B, Eggert S, Dickstein DL, Koo EH. P2-328: Role of amyloid precursor proteins and beta-amyloid-induced synaptic dysfunction Alzheimer's & Dementia. 6: S409-S409. DOI: 10.1016/J.Jalz.2010.05.1379  0.52
2009 Jäger S, Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU. alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. Journal of Neurochemistry. 111: 1369-82. PMID 19804379 DOI: 10.1111/J.1471-4159.2009.06420.X  0.92
2009 Park SA, Shaked GM, Bredesen DE, Koo EH. Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochemical and Biophysical Research Communications. 388: 450-5. PMID 19679105 DOI: 10.1016/J.Bbrc.2009.08.042  0.92
2009 Eggert S, Midthune B, Cottrell B, Koo EH. Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. The Journal of Biological Chemistry. 284: 28943-52. PMID 19596858 DOI: 10.1074/Jbc.M109.038646  0.52
2009 Lakshmana MK, Yoon IS, Chen E, Bianchi E, Koo EH, Kang DE. Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. The Journal of Biological Chemistry. 284: 11863-72. PMID 19251705 DOI: 10.1074/Jbc.M807345200  0.92
2009 Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature Medicine. 15: 331-7. PMID 19198615 DOI: 10.1038/Nm.1912  0.92
2009 Kummer MP, Maruyama H, Huelsmann C, Baches S, Weggen S, Koo EH. Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase. The Journal of Biological Chemistry. 284: 2296-306. PMID 19047044 DOI: 10.1074/Jbc.M808904200  0.92
2008 Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, ... ... Koo EH, et al. Substrate-targeting gamma-secretase modulators. Nature. 453: 925-9. PMID 18548070 DOI: 10.1038/Nature07055  0.92
2008 Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. The Journal of Biological Chemistry. 283: 17049-54. PMID 18426795 DOI: 10.1074/Jbc.M802912200  0.92
2008 Banwait S, Galvan V, Zhang J, Gorostiza OF, Ataie M, Huang W, Crippen D, Koo EH, Bredesen DE. C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 13: 1-16. PMID 18334752 DOI: 10.3233/Jad-2008-13101  0.92
2007 Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Disease and Associated Disorders. 21: 292-9. PMID 18090435 DOI: 10.1097/Wad.0B013E31815D1048  0.92
2007 Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. Bmc Neuroscience. 8: 54. PMID 17650315 DOI: 10.1186/1471-2202-8-54  0.92
2007 Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S. Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. The Journal of Biological Chemistry. 282: 24504-13. PMID 17573346 DOI: 10.1074/Jbc.M700618200  0.92
2007 Yoon IS, Chen E, Busse T, Repetto E, Lakshmana MK, Koo EH, Kang DE. Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2742-52. PMID 17463224 DOI: 10.1096/Fj.07-8114Com  0.92
2007 Calabrese B, Shaked GM, Tabarean IV, Braga J, Koo EH, Halpain S. Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Molecular and Cellular Neurosciences. 35: 183-93. PMID 17368908 DOI: 10.1016/J.Mcn.2007.02.006  0.92
2006 Saganich MJ, Schroeder BE, Galvan V, Bredesen DE, Koo EH, Heinemann SF. Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13428-36. PMID 17192425 DOI: 10.1523/Jneurosci.4180-06.2006  0.92
2006 Zheng H, Koo EH. The amyloid precursor protein: beyond amyloid. Molecular Neurodegeneration. 1: 5. PMID 16930452 DOI: 10.1186/1750-1326-1-5  0.44
2006 Shaked GM, Kummer MP, Lu DC, Galvan V, Bredesen DE, Koo EH. Abeta induces cell death by direct interaction with its cognate extracellular domain on APP (APP 597-624). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1254-6. PMID 16636103 DOI: 10.1096/Fj.05-5032Fje  0.92
2006 Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. Journal of Neurochemistry. 96: 355-65. PMID 16300630 DOI: 10.1111/J.1471-4159.2005.03553.X  0.92
2005 Schroeder BE, Koo EH. To think or not to think: synaptic activity and Abeta release. Neuron. 48: 873-5. PMID 16364890 DOI: 10.1016/J.Neuron.2005.12.005  0.92
2005 Cottrell BA, Galvan V, Banwait S, Gorostiza O, Lombardo CR, Williams T, Schilling B, Peel A, Gibson B, Koo EH, Link CD, Bredesen DE. A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Annals of Neurology. 58: 277-89. PMID 16049941 DOI: 10.1002/Ana.20554  0.92
2005 Kang DE, Yoon IS, Repetto E, Busse T, Yermian N, Ie L, Koo EH. Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. The Journal of Biological Chemistry. 280: 31537-47. PMID 16014629 DOI: 10.1074/Jbc.M500833200  0.92
2005 Chevallier NL, Soriano S, Kang DE, Masliah E, Hu G, Koo EH. Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. The American Journal of Pathology. 167: 151-9. PMID 15972961 DOI: 10.1016/S0002-9440(10)62962-8  0.92
2005 Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. The Journal of Biological Chemistry. 280: 27303-9. PMID 15917251 DOI: 10.1074/Jbc.M413969200  0.92
2005 Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, ... ... Koo EH, et al. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nature Medicine. 11: 545-50. PMID 15834426 DOI: 10.1038/Nm1235  0.92
2005 Yoon IS, Pietrzik CU, Kang DE, Koo EH. Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. The Journal of Biological Chemistry. 280: 20140-7. PMID 15772078 DOI: 10.1074/Jbc.M413729200  0.92
2004 Sodhi CP, Rampalli S, Perez RG, Koo EH, Quinn B, Gottardi-Littell NR. The endocytotic pathway is required for increased A beta 42 secretion during apoptosis. Brain Research. Molecular Brain Research. 128: 201-11. PMID 15363895 DOI: 10.1016/J.Molbrainres.2004.06.012  0.4
2004 Koo EH, Kopan R. Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nature Medicine. 10: S26-33. PMID 15272268 DOI: 10.1038/Nm1065  0.92
2004 Pietrzik CU, Yoon IS, Jaeger S, Busse T, Weggen S, Koo EH. FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4259-65. PMID 15115822 DOI: 10.1523/Jneurosci.5451-03.2004  0.92
2003 Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH. Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Annals of Neurology. 54: 781-9. PMID 14681887 DOI: 10.1002/Ana.10761  0.92
2003 Lu DC, Soriano S, Bredesen DE, Koo EH. Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. Journal of Neurochemistry. 87: 733-41. PMID 14535955 DOI: 10.1046/J.1471-4159.2003.02059.X  0.92
2003 Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. The Journal of Clinical Investigation. 112: 440-9. PMID 12897211 DOI: 10.1172/Jci18162  0.92
2003 Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. The Journal of Biological Chemistry. 278: 31831-7. PMID 12805356 DOI: 10.1074/Jbc.M303592200  0.92
2003 Sagi SA, Weggen S, Eriksen J, Golde TE, Koo EH. The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production. The Journal of Biological Chemistry. 278: 31825-30. PMID 12805355 DOI: 10.1074/Jbc.M303588200  0.92
2003 Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. The Journal of Biological Chemistry. 278: 30748-54. PMID 12777371 DOI: 10.1074/Jbc.M304824200  0.92
2003 Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 24294-301. PMID 12707272 DOI: 10.1074/Jbc.M211161200  0.92
2002 Leem JY, Saura CA, Pietrzik C, Christianson J, Wanamaker C, King LT, Veselits ML, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo EH, Thinakaran G. A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiology of Disease. 11: 64-82. PMID 12460547 DOI: 10.1006/Nbdi.2002.0546  0.92
2002 Pietrzik CU, Busse T, Merriam DE, Weggen S, Koo EH. The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. The Embo Journal. 21: 5691-700. PMID 12411487 DOI: 10.1093/Emboj/Cdf568  0.92
2002 Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell. 110: 751-62. PMID 12297048 DOI: 10.1016/S0092-8674(02)00970-4  0.92
2002 Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell. 110: 55-67. PMID 12150997 DOI: 10.1016/S0092-8674(02)00809-7  0.92
2002 Galvan V, Chen S, Lu D, Logvinova A, Goldsmith P, Koo EH, Bredesen DE. Caspase cleavage of members of the amyloid precursor family of proteins. Journal of Neurochemistry. 82: 283-94. PMID 12124429 DOI: 10.1046/J.1471-4159.2002.00970.X  0.92
2002 Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 99: 8760-5. PMID 12070348 DOI: 10.1073/Pnas.132045399  0.88
2002 Golde TE, Eriksen JL, Weggen S, Sagi SA, Koo EH. Nonsteroidal antiinflammatory drugs as therapeutic agents for Alzheimer's disease Drug Development Research. 56: 415-420. DOI: 10.1002/Ddr.10093  0.92
2001 Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414: 212-6. PMID 11700559 DOI: 10.1038/35102591  0.92
2001 Xia X, Qian S, Soriano S, Wu Y, Fletcher AM, Wang XJ, Koo EH, Wu X, Zheng H. Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 10863-8. PMID 11517342 DOI: 10.1073/Pnas.191284198  0.92
2001 Zhu G, Wang D, Lin YH, McMahon T, Koo EH, Messing RO. Protein kinase C epsilon suppresses Abeta production and promotes activation of alpha-secretase. Biochemical and Biophysical Research Communications. 285: 997-1006. PMID 11467851 DOI: 10.1006/Bbrc.2001.5273  0.92
2001 Soriano S, Lu DC, Chandra S, Pietrzik CU, Koo EH. The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspases. The Journal of Biological Chemistry. 276: 29045-50. PMID 11397796 DOI: 10.1074/Jbc.M102456200  0.92
2001 Soriano S, Kang DE, Fu M, Pestell R, Chevallier N, Zheng H, Koo EH. Presenilin 1 negatively regulates beta-catenin/T cell factor/lymphoid enhancer factor-1 signaling independently of beta-amyloid precursor protein and notch processing. The Journal of Cell Biology. 152: 785-94. PMID 11266469 DOI: 10.1083/Jcb.152.4.785  0.92
2000 Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. The Journal of Clinical Investigation. 106: 1159-66. PMID 11067868 DOI: 10.1172/Jci11013  0.92
2000 Van Uden E, Kang DE, Koo EH, Masliah E. LDL receptor-related protein (LRP) in Alzheimer's disease: towards a unified theory of pathogenesis. Microscopy Research and Technique. 50: 268-72. PMID 10936878 DOI: 10.1002/1097-0029(20000815)50:4<268::Aid-Jemt3>3.0.Co;2-1  0.92
2000 Saura CA, Tomita T, Soriano S, Takahashi M, Leem JY, Honda T, Koo EH, Iwatsubo T, Thinakaran G. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants. The Journal of Biological Chemistry. 275: 17136-42. PMID 10748144 DOI: 10.1074/jbc.M909624199  0.88
2000 Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nature Medicine. 6: 397-404. PMID 10742146 DOI: 10.1038/74656  0.92
2000 Kuo YM, Kokjohn TA, Kalback W, Luehrs D, Galasko DR, Chevallier N, Koo EH, Emmerling MR, Roher AE. Amyloid-beta peptides interact with plasma proteins and erythrocytes: implications for their quantitation in plasma. Biochemical and Biophysical Research Communications. 268: 750-6. PMID 10679277 DOI: 10.1006/Bbrc.2000.2222  0.92
2000 Sabbagh MN, Galasko D, Koo E, Thal LJ. Amyloid-β and treatment opportunities for Alzheimer's disease Journal of Alzheimer's Disease. 2: 231-259.  0.92
1999 Soriano S, Chyung AS, Chen X, Stokin GB, Lee VM, Koo EH. Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments. The Journal of Biological Chemistry. 274: 32295-300. PMID 10542269 DOI: 10.1074/jbc.274.45.32295  0.92
1999 Perez RG, Soriano S, Hayes JD, Ostaszewski B, Xia W, Selkoe DJ, Chen X, Stokin GB, Koo EH. Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42. The Journal of Biological Chemistry. 274: 18851-6. PMID 10383380 DOI: 10.1074/jbc.274.27.18851  0.92
1999 Kang DE, Soriano S, Frosch MP, Collins T, Naruse S, Sisodia SS, Leibowitz G, Levine F, Koo EH. Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4229-37. PMID 10341227  0.92
1999 Hong CS, Caromile L, Nomata Y, Mori H, Bredesen DE, Koo EH. Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 637-43. PMID 9880584 DOI: 10.1523/Jneurosci.19-02-00637.1999  0.92
1998 Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi. Biochemistry. 37: 16465-71. PMID 9843412 DOI: 10.1021/Bi9816195  0.92
1998 Perez RG, Koo EH. When less says more: clues from a missing Alzheimer-associated protein. Molecular Psychiatry. 3: 378-80. PMID 9774769  0.4
1998 Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH. Subcellular distribution and turnover of presenilins in transfected cells. The Journal of Biological Chemistry. 273: 12436-42. PMID 9575200 DOI: 10.1074/Jbc.273.20.12436  0.92
1997 Perez RG, Zheng H, Van der Ploeg LH, Koo EH. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 9407-14. PMID 9390996  0.44
1997 Sawamura N, Tamaoka A, Shoji S, Koo EH, Walker LC, Mori H. Characterization of amyloid beta protein species in cerebral amyloid angiopathy of a squirrel monkey by immunocytochemistry and enzyme-linked immunosorbent assay. Brain Research. 764: 225-9. PMID 9295214 DOI: 10.1016/S0006-8993(97)00624-0  0.92
1997 Xia W, Zhang J, Perez R, Koo EH, Selkoe DJ. Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 94: 8208-13. PMID 9223340 DOI: 10.1073/Pnas.94.15.8208  0.68
1997 Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease. 3: 325-37. PMID 9173929 DOI: 10.1006/Nbdi.1997.0129  0.92
1997 Hong CS, Koo EH. Isolation and characterization of Drosophila presenilin homolog. Neuroreport. 8: 665-8. PMID 9106743 DOI: 10.1097/00001756-199702100-00017  0.92
1997 Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. The Journal of Biological Chemistry. 272: 7977-82. PMID 9065468 DOI: 10.1074/Jbc.272.12.7977  0.92
1997 Yamazaki T, Koo EH, Selkoe DJ. Cell surface amyloid beta-protein precursor colocalizes with beta 1 integrins at substrate contact sites in neural cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1004-10. PMID 8994055 DOI: 10.1523/Jneurosci.17-03-01004.1997  0.68
1997 Marquez-Sterling NR, Lo AC, Sisodia SS, Koo EH. Trafficking of cell-surface beta-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 140-51. PMID 8987743 DOI: 10.1523/Jneurosci.17-01-00140.1997  0.4
1996 Crain BJ, Hu W, Sze CI, Slunt HH, Koo EH, Price DL, Thinakaran G, Sisodia SS. Expression and distribution of amyloid precursor protein-like protein-2 in Alzheimer's disease and in normal brain. The American Journal of Pathology. 149: 1087-95. PMID 8863657  0.4
1996 Lemere CA, Lopera F, Kosik KS, Lendon CL, Ossa J, Saido TC, Yamaguchi H, Ruiz A, Martinez A, Madrigal L, Hincapie L, Arango JC, Anthony DC, Koo EH, Goate AM, et al. The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology. Nature Medicine. 2: 1146-50. PMID 8837617 DOI: 10.1038/Nm1096-1146  0.92
1996 Yamazaki T, Koo EH, Selkoe DJ. Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization. Journal of Cell Science. 109: 999-1008. PMID 8743947  0.68
1996 Koo EH, Squazzo SL, Selkoe DJ, Koo CH. Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody. Journal of Cell Science. 109: 991-8. PMID 8743946  0.68
1996 Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Annals of the New York Academy of Sciences. 777: 57-64. PMID 8624127 DOI: 10.1111/J.1749-6632.1996.Tb34401.X  0.92
1996 Perez RG, Squazzo SL, Koo EH. Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways. The Journal of Biological Chemistry. 271: 9100-7. PMID 8621560 DOI: 10.1074/jbc.271.15.9100  0.6
1995 Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 2157-67. PMID 7891158 DOI: 10.1523/Jneurosci.15-03-02157.1995  0.92
1995 Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. The Journal of Cell Biology. 128: 537-47. PMID 7860629 DOI: 10.1083/Jcb.128.4.537  0.92
1995 Yamazaki T, Selkoe DJ, Koo EH. Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. The Journal of Cell Biology. 129: 431-42. PMID 7721945 DOI: 10.1083/Jcb.129.2.431  0.68
1995 Podlisny MB, Ostaszewski BL, Squazzo SL, Koo EH, Rydell RE, Teplow DB, Selkoe DJ. Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. The Journal of Biological Chemistry. 270: 9564-70. PMID 7721886 DOI: 10.1074/Jbc.270.16.9564  0.92
1994 Haass C, Koo EH, Teplow DB, Selkoe DJ. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 1564-8. PMID 8108445 DOI: 10.1073/Pnas.91.4.1564  0.92
1994 Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 91: 7104-8. PMID 8041753 DOI: 10.1073/Pnas.91.15.7104  0.68
1994 Koo EH, Squazzo SL. Evidence that production and release of amyloid beta-protein involves the endocytic pathway. The Journal of Biological Chemistry. 269: 17386-9. PMID 8021238  0.6
1993 Koo EH, Park L, Selkoe DJ. Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 90: 4748-52. PMID 8506329 DOI: 10.1073/Pnas.90.10.4748  0.68
1993 Buxbaum JD, Koo EH, Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proceedings of the National Academy of Sciences of the United States of America. 90: 9195-8. PMID 8415676 DOI: 10.1073/Pnas.90.19.9195  0.92
1993 Sisodia SS, Koo EH, Hoffman PN, Perry G, Price DL. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 3136-42. PMID 8331390  0.4
1992 Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 357: 500-3. PMID 1608449 DOI: 10.1038/357500A0  0.68
1992 Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proceedings of the National Academy of Sciences of the United States of America. 89: 9439-43. PMID 1409654 DOI: 10.1073/Pnas.89.20.9439  0.68
1992 Razzaboni BL, Papastoitsis G, Koo EH, Abraham CR. A calcium-stimulated serine protease from monkey brain degrades the beta-amyloid precursor protein. Brain Research. 589: 207-16. PMID 1393590 DOI: 10.1016/0006-8993(92)91279-N  0.92
1992 Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 359: 322-5. PMID 1383826 DOI: 10.1038/359322A0  0.92
1992 Gandy SE, Bhasin R, Ramabhadran TV, Koo EH, Price DL, Goldgaber D, Greengard P. Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment. Journal of Neurochemistry. 58: 383-6. PMID 1345769 DOI: 10.1111/j.1471-4159.1992.tb09322.x  0.92
1991 Price DL, Koliatsos VE, Sisodia SS, Koo EH, Martin LJ, Walker LC, Appelgate MD, Cork LC. Amyloid-related proteins and nerve growth factor in Alzheimer's disease and animal models. Clinical Neuropharmacology. 14: S9-14. PMID 1913711 DOI: 10.1097/00002826-199114001-00003  0.92
1991 Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL. Amyloid precursor protein in aged nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. 88: 1461-5. PMID 1899927 DOI: 10.1073/Pnas.88.4.1461  0.4
1991 Koo EH, Abraham CR, Potter H, Cork LC, Price DL. Developmental expression of alpha 1-antichymotrypsin in brain may be related to astrogliosis. Neurobiology of Aging. 12: 495-501. PMID 1837594 DOI: 10.1016/0197-4580(91)90079-Y  0.92
1991 Abraham CR, Razzaboni BL, Sisodia SS, Koo EH, Price DL, Van Nostrand WE, Papastoitsis G. Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain. Annals of the New York Academy of Sciences. 640: 161-5. PMID 1776735 DOI: 10.1111/J.1749-6632.1991.Tb00209.X  0.92
1991 Price DL, Martin LJ, Sisodia SS, Wagster MV, Koo EH, Walker LC, Koliatsos VE, Cork LC. Aged non-human primates: an animal model of age-associated neurodegenerative disease. Brain Pathology (Zurich, Switzerland). 1: 287-96. PMID 1688300 DOI: 10.1111/J.1750-3639.1991.Tb00672.X  0.92
1990 Price DL, Koo EH, Wagster MV, Walker LC, Wenk GL, Applegate MD, Kitt CA, Cork LC. Behavioral, cellular, and molecular biological studies of aged nonhuman primates. Advances in Neurology. 51: 83-9. PMID 2403719  0.92
1990 Price DL, Sisodia SS, Koo EH, Muma NA, Kitt CA, Walker LC, Martin LJ, Troncoso JC, Griffin JW, Hoffman PN. Neuronal disorders: studies of animal models and human diseases. Toxicologic Pathology. 18: 128-37. PMID 2195633 DOI: 10.1177/019262339001800118  0.92
1990 Koo EH, Sisodia SS, Cork LC, Unterbeck A, Bayney RM, Price DL. Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates. Neuron. 4: 97-104. PMID 2106906 DOI: 10.1016/0896-6273(90)90446-M  0.4
1990 Price DL, Koo EH, Sisodia SS, Martin LJ, Koliatsos VE, Muma NA, Walker LC, Cork LC. Neuronal responses to injury and aging: lessons from animal models. Progress in Brain Research. 86: 297-308. PMID 2087560 DOI: 10.1016/S0079-6123(08)63186-6  0.92
1990 Sisodia SS, Koo EH, Beyreuther K, Unterbeck A, Price DL. Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processing. Science (New York, N.Y.). 248: 492-5. PMID 1691865 DOI: 10.1126/Science.1691865  0.4
1990 Koo EH, Sisodia SS, Archer DR, Martin LJ, Weidemann A, Beyreuther K, Fischer P, Masters CL, Price DL. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proceedings of the National Academy of Sciences of the United States of America. 87: 1561-5. PMID 1689489 DOI: 10.1073/Pnas.87.4.1561  0.4
1989 Price DL, Koo EH, Unterbeck A. Cellular and molecular biology of Alzheimer's disease. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 10: 69-74. PMID 2655587 DOI: 10.1002/bies.950100208  0.4
1988 Muma NA, Troncoso JC, Hoffman PN, Koo EH, Price DL. Aluminum neurotoxicity: altered expression of cytoskeletal genes. Brain Research. 427: 115-21. PMID 3382937 DOI: 10.1016/0169-328X(88)90056-3  0.92
1988 Koo EH, Hoffman PN, Price DL. Levels of neurotransmitter and cytoskeletal protein mRNAs during nerve regeneration in sympathetic ganglia. Brain Research. 449: 361-3. PMID 2899448  0.4
1988 Muma NA, Troncoso JC, Hoffman PN, Koo EH, Price DL. Aluminum neurotoxicity: altered expression of cytoskeletal genes Molecular Brain Research. 3: 115-121. DOI: 10.1016/0169-328X(88)90056-3  0.92
1987 Warren AC, Robakis NK, Ramakrishna N, Koo EH, Ross CA, Robb AS, Folstein MF, Price DL, Antonarakis SE. beta-Amyloid gene is not present in three copies in autopsy-validated Alzheimer's disease. Genomics. 1: 307-12. PMID 2966761 DOI: 10.1016/0888-7543(87)90029-2  0.92
Show low-probability matches.