Koichi Okamoto, MD PhD - Publications

Affiliations: 
Neurology Gunma University, Maebashi-shi, Gunma-ken, Japan 

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Year Citation  Score
2020 Nakamura R, Tohnai G, Atsuta N, Nakatochi M, Hayashi N, Watanabe H, Yokoi D, Watanabe H, Katsuno M, Izumi Y, Taniguchi A, Kanai K, Morita M, Kano O, Kuwabara S, ... ... Okamoto K, et al. Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. PMID 32888732 DOI: 10.1016/J.Neurobiolaging.2020.07.010  0.308
2020 Okamoto K, Amari M, Fukuda T, Suzuki K, Takatama M. Amyloid-β plaques may be reduced in advanced stages of cerebral amyloid angiopathy in the elderly. Neuropathology : Official Journal of the Japanese Society of Neuropathology. PMID 32557936 DOI: 10.1111/Neup.12662  0.316
2018 Kobayakawa Y, Masaki K, Yamasaki R, Shiraishi W, Hayashida S, Hayashi S, Okamoto K, Matsushita T, Kira JI. Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis. Frontiers in Neuroscience. 12: 894. PMID 30546295 DOI: 10.3389/Fnins.2018.00894  0.326
2017 Tohnai G, Nakamura R, Sone J, Nakatochi M, Yokoi D, Katsuno M, Watanabe H, Watanabe H, Ito M, Li Y, Izumi Y, Morita M, Taniguchi A, Kano O, Oda M, ... ... Okamoto K, et al. Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. PMID 29398122 DOI: 10.1016/J.Neurobiolaging.2017.12.005  0.319
2017 Okamoto K, Naito I, Fukuda T, Suzuki K, Takatama M. Adult moyamoya disease associated with abundant phosphorylated tau accumulation in the brainstem: Report of a case with autopsy findings. Neuropathology : Official Journal of the Japanese Society of Neuropathology. PMID 29282774 DOI: 10.1111/Neup.12455  0.355
2017 Hayashi S, Akao N, Okamoto K. Meningeal plasma cell granuloma in the early stage of relapsing polychondritis. Rinsho Shinkeigaku = Clinical Neurology. PMID 28552866 DOI: 10.5692/Clinicalneurol.Cn-000975  0.3
2017 Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, ... ... Okamoto K, et al. The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28539470 DOI: 10.1126/Scitranslmed.Aaf3962  0.58
2017 Tajima H, Ohta T, Shinbashi H, Hirose A, Okazaki M, Yamaguchi T, Ohbatake Y, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Nakamura K, Hayashi H, Oyama K, et al. Phase I study of weekly palliative chemotherapy with low-dose third-line paclitaxel for biliary tract cancer. Molecular and Clinical Oncology. 6: 753-757. PMID 28529750 DOI: 10.3892/mco.2017.1206  0.301
2017 Okamoto K, Amari M, Fukuda T, Suzuki K, Takatama M. Comparison of AT8 immunoreactivity in the locus ceruleus and hippocampus of 154 brains from routine autopsies. Neuropathology : Official Journal of the Japanese Society of Neuropathology. PMID 28168741 DOI: 10.1111/Neup.12367  0.33
2015 Nagamine S, Yamazaki T, Makioka K, Fujita Y, Ikeda M, Takatama M, Okamoto K, Yokoo H, Ikeda Y. Hypersialylation is a common feature of neurofibrillary tangles and granulovacuolar degenerations in Alzheimer's disease and tauopathy brains. Neuropathology : Official Journal of the Japanese Society of Neuropathology. PMID 26685795 DOI: 10.1111/Neup.12277  0.358
2015 Furuta N, Ishizawa K, Shibata M, Tsukagoshi S, Nagamine S, Makioka K, Fujita Y, Ikeda M, Yoshimura S, Motomura M, Okamoto K, Ikeda Y. Anti-MuSK Antibody-positive Myasthenia Gravis Mimicking Amyotrophic Lateral Sclerosis. Internal Medicine (Tokyo, Japan). 54: 2497-501. PMID 26424311 DOI: 10.2169/Internalmedicine.54.4645  0.305
2015 Oyama T, Okamoto K, Nakamura R, Tajiri R, Ikeda H, Ninomiya I, Ooi A. Overexpression and gene amplification of both ERBB2 and EGFR in an esophageal squamous cell carcinoma revealed by fluorescence in situ hybridization, multiplex ligation-dependent probe amplification and immunohistochemistry. Pathology International. 65: 608-13. PMID 26314265 DOI: 10.1111/pin.12344  0.405
2015 Okamoto K, Fujita Y, Hoshino E, Tamura Y, Fukuda T, Hasegawa M, Takatama M. An autopsy case of familial amyotrophic lateral sclerosis with a TARDBP Q343R mutation. Neuropathology : Official Journal of the Japanese Society of Neuropathology. PMID 26096467 DOI: 10.1111/Neup.12209  0.364
2015 Watanabe H, Atsuta N, Nakamura R, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Izumi Y, Morita M, Tomiyama H, Taniguchi A, Aiba I, Abe K, Mizoguchi K, ... ... Okamoto K, et al. Factors affecting longitudinal functional decline and survival in amyotrophic lateral sclerosis patients. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 16: 230-6. PMID 25548957 DOI: 10.3109/21678421.2014.990036  0.57
2015 Oyama K, Fushida S, Tsukada T, Kinoshita J, Watanabe T, Shoji M, Nakanuma S, Okamoto K, Sakai S, Makino I, Nakamura K, Hayashi H, Inokuchi M, Nakagawara H, Miyashita T, et al. Evaluation of serum HER2-ECD levels in patients with gastric cancer. Journal of Gastroenterology. 50: 41-5. PMID 24557054 DOI: 10.1007/s00535-014-0941-3  0.406
2014 Ikeda M, Tashiro Y, Takai E, Kurose S, Fugami N, Tsuda K, Arisaka Y, Kodaira S, Fujita Y, Makioka K, Mizuno Y, Shimada H, Harigaya Y, Takatama M, Amari M, ... ... Okamoto K, et al. CSF levels of Aβ1-38/Aβ1-40/Aβ1-42 and (11)C PiB-PET studies in three clinical variants of primary progressive aphasia and Alzheimer's disease. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 21: 238-45. PMID 25139672 DOI: 10.3109/13506129.2014.949231  0.309
2014 Okamoto K, Amari M, Fujita Y, Makioka K, Fukuda T, Suzuki K, Takatama M. Cytoplasmic TDP-43 accumulation in cells of the adrenal medulla in individuals with or without amyotrophic lateral sclerosis. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 34: 535-40. PMID 25039310 DOI: 10.1111/Neup.12139  0.327
2014 Sato M, Muguruma N, Nakagawa T, Okamoto K, Kimura T, Kitamura S, Yano H, Sannomiya K, Goji T, Miyamoto H, Okahisa T, Mikasa H, Wada S, Iwata M, Takayama T. High antitumor activity of pladienolide B and its derivative in gastric cancer. Cancer Science. 105: 110-6. PMID 24635824 DOI: 10.1111/cas.12317  0.352
2014 Makioka K, Yamazaki T, Takatama M, Ikeda M, Okamoto K. Immunolocalization of Smurf1 in Hirano bodies. Journal of the Neurological Sciences. 336: 24-8. PMID 24238996 DOI: 10.1016/J.Jns.2013.09.028  0.354
2014 Oyama K, Fushida S, Tsukada T, Kinoshita J, Watanabe T, Shoji M, Nakanuma S, Okamoto K, Sakai S, Makino I, Nakamura K, Hayashi H, Inokuchi M, Nakagawara H, Miyashita T, et al. Erratum to: Evaluation of serum HER2-ECD levels in patients with gastric cancer Journal of Gastroenterology. 50: 121-122. DOI: 10.1007/s00535-014-0962-y  0.407
2013 Nakamura R, Atsuta N, Watanabe H, Hirakawa A, Watanabe H, Ito M, Senda J, Katsuno M, Tanaka F, Izumi Y, Morita M, Ogaki K, Taniguchi A, Aiba I, Mizoguchi K, ... Okamoto K, et al. Neck weakness is a potent prognostic factor in sporadic amyotrophic lateral sclerosis patients. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 1365-71. PMID 23933739 DOI: 10.1136/Jnnp-2013-306020  0.573
2013 Furuta N, Makioka K, Fujita Y, Okamoto K. Changes in the clinical features of amyotrophic lateral sclerosis in rural Japan. Internal Medicine (Tokyo, Japan). 52: 1691-6. PMID 23903501 DOI: 10.2169/Internalmedicine.52.0195  0.337
2013 Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, et al. A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytes. Gastroenterology. 145: 865-73. PMID 23791700 DOI: 10.1053/j.gastro.2013.06.012  0.332
2013 Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, ... ... Okamoto K, et al. Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells". Science Translational Medicine. 5: 188lr2. PMID 23740898 DOI: 10.1126/Scitranslmed.3005697  0.585
2013 Ikeda M, Yonemura K, Kakuda S, Tashiro Y, Fujita Y, Takai E, Hashimoto Y, Makioka K, Furuta N, Ishiguro K, Maruki R, Yoshida J, Miyaguchi O, Tsukie T, Kuwano R, ... ... Okamoto K, et al. Cerebrospinal fluid levels of phosphorylated tau and Aβ1-38/Aβ1-40/Aβ1-42 in Alzheimer's disease with PS1 mutations. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 20: 107-12. PMID 23638752 DOI: 10.3109/13506129.2013.790810  0.44
2013 Sakurai A, Makioka K, Fukuda T, Takatama M, Okamoto K. Accumulation of phosphorylated TDP-43 in the CNS of a patient with Cockayne syndrome. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 33: 673-7. PMID 23581709 DOI: 10.1111/Neup.12038  0.368
2013 Furuta N, Makioka K, Fujita Y, Ikeda M, Takatama M, Matsuoka M, Okamoto K. Reduced expression of BTBD10 in anterior horn cells with Golgi fragmentation and pTDP-43-positive inclusions in patients with sporadic amyotrophic lateral sclerosis. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 33: 397-404. PMID 23320755 DOI: 10.1111/Neup.12010  0.371
2012 Ikeda M, Hirayanagi K, Arai M, Kakuda S, Makioka K, Furuta N, Takai E, Kasahara H, Tsukagoshi S, Fujita Y, Amari M, Takatama M, Nakazato Y, Okamoto K. Encephalopathy with amyloid angiopathy and numerous amyloid plaques with low levels of CSF Aβ1-40/Aβ1-42. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 19: 186-90. PMID 22994303 DOI: 10.3109/13506129.2012.725113  0.318
2012 Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T, Okita K, Asaka I, Aoi T, Watanabe A, Yamada Y, Morizane A, Takahashi J, ... ... Okamoto K, et al. Drug screening for ALS using patient-specific induced pluripotent stem cells. Science Translational Medicine. 4: 145ra104. PMID 22855461 DOI: 10.1126/Scitranslmed.3004052  0.639
2012 Ikeda Y, Ohta Y, Kobayashi H, Okamoto M, Takamatsu K, Ota T, Manabe Y, Okamoto K, Koizumi A, Abe K. Clinical features of SCA36: a novel spinocerebellar ataxia with motor neuron involvement (Asidan). Neurology. 79: 333-41. PMID 22744658 DOI: 10.1212/Wnl.0B013E318260436F  0.371
2012 Nawa M, Kage-Nakadai E, Aiso S, Okamoto K, Mitani S, Matsuoka M. Reduced expression of BTBD10, an Akt activator, leads to motor neuron death Cell Death and Differentiation. 19: 1398-1407. PMID 22388351 DOI: 10.1038/Cdd.2012.19  0.336
2012 Makioka K, Yamazaki T, Takatama M, Nakazato Y, Okamoto K. Activation and alteration of lysosomes in multiple system atrophy. Neuroreport. 23: 270-6. PMID 22343695 DOI: 10.1097/Wnr.0B013E3283503E4F  0.332
2012 Mizuno Y, Fujita Y, Takatama M, Okamoto K. Comparison of phosphorylated TDP-43-positive inclusions in oculomotor neurons in patients with non-ALS and ALS disorders. Journal of the Neurological Sciences. 315: 20-5. PMID 22257502 DOI: 10.1016/J.Jns.2011.12.012  0.374
2011 Yamaguchi H, Takahashi S, Kosaka K, Okamoto K, Yamazaki T, Ikeda M, Osawa M, Amari M, Harigaya Y, Awata S, Maki Y. Yamaguchi fox-pigeon imitation test (YFPIT) for dementia in clinical practice. Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society. 11: 221-6. PMID 22151241 DOI: 10.1111/J.1479-8301.2011.00373.X  0.498
2011 Osawa T, Mizuno Y, Fujita Y, Takatama M, Nakazato Y, Okamoto K. Optineurin in neurodegenerative diseases. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 31: 569-74. PMID 21284751 DOI: 10.1111/J.1440-1789.2011.01199.X  0.388
2011 Mizuno Y, Fujita Y, Takatama M, Okamoto K. Peripherin partially localizes in Bunina bodies in amyotrophic lateral sclerosis Journal of the Neurological Sciences. 302: 14-18. PMID 21241994 DOI: 10.1016/J.Jns.2010.12.023  0.342
2011 Fujita Y, Fujita S, Takatama M, Ikeda M, Okamoto K. Numerous FUS-positive inclusions in an elderly woman with motor neuron disease Neuropathology. 31: 170-176. PMID 20667018 DOI: 10.1111/J.1440-1789.2010.01146.X  0.381
2011 Fujita Y, Watabe K, Ikeda K, Mizuno Y, Okamoto K. Morphological changes of Golgi apparatus in adult rats after facial nerve injuries. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 31: 42-7. PMID 20497344 DOI: 10.1111/J.1440-1789.2010.01123.X  0.318
2010 Yamamoto-Watanabe Y, Watanabe M, Okamoto K, Fujita Y, Jackson M, Ikeda M, Nakazato Y, Ikeda Y, Matsubara E, Kawarabayashi T, Shoji M. A Japanese ALS6 family with mutation R521C in the FUS/TLS gene: a clinical, pathological and genetic report. Journal of the Neurological Sciences. 296: 59-63. PMID 20621307 DOI: 10.1016/J.Jns.2010.06.008  0.313
2010 Noguchi A, Nawa M, Aiso S, Okamoto K, Matsuoka M. Transforming growth factor β2 level is elevated in neurons of Alzheimer's disease brains International Journal of Neuroscience. 120: 168-175. PMID 20374083 DOI: 10.3109/00207450903139689  0.351
2010 Okamoto K, Fujita Y, Mizuno Y. Pathology of protein synthesis and degradation systems in ALS Neuropathology. 30: 189-193. PMID 20102523 DOI: 10.1111/J.1440-1789.2009.01088.X  0.323
2010 Okamoto K. Ubiquitin-positive tau-negative intraneuronal inclusions in dementia with motor neuron disease: The 50th Anniversary of Japanese Society of Neuropathology Neuropathology. 30: 486-489. DOI: 10.1111/J.1440-1789.2010.01121.X  0.39
2009 Kadokura A, Yamazaki T, Kakuda S, Makioka K, Lemere CA, Fujita Y, Takatama M, Okamoto K. Phosphorylation-dependent TDP-43 antibody detects intraneuronal dot-like structures showing morphological characters of granulovacuolar degeneration Neuroscience Letters. 463: 87-92. PMID 19539703 DOI: 10.1016/J.Neulet.2009.06.024  0.352
2009 Kadokura A, Yamazaki T, Lemere CA, Takatama M, Okamoto K. Regional distribution of TDP-43 inclusions in Alzheimer disease (AD) brains: Their relation to AD common pathology: Original Article Neuropathology. 29: 566-573. PMID 19422539 DOI: 10.1111/J.1440-1789.2009.01017.X  0.363
2009 Ikeda M, Kawarabayashi T, Harigaya Y, Sasaki A, Yamada S, Matsubara E, Murakami T, Tanaka Y, Kurata T, Wuhua X, Ueda K, Kuribara H, Ikarashi Y, Nakazato Y, Okamoto K, et al. Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathology. Brain Research. 1250: 232-41. PMID 18992718 DOI: 10.1016/J.Brainres.2008.10.011  0.326
2008 Yokoseki A, Shiga A, Tan CF, Tagawa A, Kaneko H, Koyama A, Eguchi H, Tsujino A, Ikeuchi T, Kakita A, Okamoto K, Nishizawa M, Takahashi H, Onodera O. TDP-43 mutation in familial amyotrophic lateral sclerosis Annals of Neurology. 63: 538-542. PMID 18438952 DOI: 10.1002/Ana.21392  0.35
2008 Hashimoto Y, Muramatsu K, Uemura T, Harada R, Sato T, Okamoto K, Harada A. Neuron-specific and inducible recombination by Cre recombinase in the mouse Neuroreport. 19: 621-624. PMID 18382274 DOI: 10.1097/Wnr.0B013E3282Fb7D99  0.31
2008 Okamoto K, Yamazaki T, Banno H, Sobue G, Yoshida M, Takatama M. Neuropathological studies of patients with possible non-herpetic acute limbic encephalitis and so-called acute juvenile female non-herpetic encephalitis Internal Medicine. 47: 231-236. PMID 18277022 DOI: 10.2169/Internalmedicine.47.0547  0.313
2008 Fujita Y, Mizuno Y, Takatama M, Okamoto K. Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS Journal of the Neurological Sciences. 269: 30-34. PMID 18206910 DOI: 10.1016/J.Jns.2007.12.016  0.354
2008 Okamoto K, Mizuno Y, Fujita Y. Bunina bodies in amyotrophic lateral sclerosis Neuropathology. 28: 109-115. PMID 18069968 DOI: 10.1111/J.1440-1789.2007.00873.X  0.35
2007 Sasabe J, Chiba T, Yamada M, Okamoto K, Nishimoto I, Matsuoka M, Aiso S. D-Serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis Embo Journal. 26: 4149-4159. PMID 17762863 DOI: 10.1038/Sj.Emboj.7601840  0.31
2007 Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathologica. 114: 5-22. PMID 17579875 DOI: 10.1007/S00401-007-0237-2  0.338
2007 Hayashi S, Amari M, Takatama M, Okamoto K. Morphometric and topographical studies of small neurons in sporadic amyotrophic lateral sclerosis spinal gray matter Neuropathology. 27: 121-126. PMID 17494512 DOI: 10.1111/J.1440-1789.2007.00754.X  0.331
2007 Hayashi S, Yamazaki T, Okamoto K. Nonapoptotic cell death caused by the inhibition of RNA polymerase disrupts organelle distribution Journal of the Neurological Sciences. 256: 10-20. PMID 17360003 DOI: 10.1016/J.Jns.2007.01.077  0.305
2006 Mizuno Y, Amari M, Takatama M, Aizawa H, Mihara B, Okamoto K. Transferrin localizes in Bunina bodies in amyotrophic lateral sclerosis. Acta Neuropathologica. 112: 597-603. PMID 16896902 DOI: 10.1007/S00401-006-0122-4  0.316
2006 Fujita Y, Ohama E, Takatama M, Al-Sarraj S, Okamoto K. Fragmentation of Golgi apparatus of nigral neurons with alpha-synuclein-positive inclusions in patients with Parkinson's disease. Acta Neuropathologica. 112: 261-5. PMID 16855830 DOI: 10.1007/S00401-006-0114-4  0.319
2006 Mizuno Y, Amari M, Takatama M, Aizawa H, Mihara B, Okamoto K. Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis. Journal of the Neurological Sciences. 249: 13-8. PMID 16820172 DOI: 10.1016/J.Jns.2006.05.060  0.363
2006 Mizuno Y, Ohama E, Hirato J, Nakazato Y, Takahashi H, Takatama M, Takeuchi T, Okamoto K. Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease. Journal of the Neurological Sciences. 246: 131-7. PMID 16616189 DOI: 10.1016/J.Jns.2006.02.019  0.312
2006 Watanabe M, Jackson M, Ikeda M, Mizushima K, Amari M, Takatama M, Hirai S, Ikeda Y, Shizuka-Ikeda M, Okamoto K. Genetic analysis of the cystatin C gene in familial and sporadic ALS patients Brain Research. 1073: 20-24. PMID 16443201 DOI: 10.1016/J.Brainres.2005.12.046  0.318
2005 Fujita Y, Okamoto K. Golgi apparatus of the motor neurons in patients with amyotrophic lateral sclerosis and in mice models of amyotrophic lateral sclerosis Neuropathology. 25: 388-394. PMID 16382790 DOI: 10.1111/J.1440-1789.2005.00616.X  0.36
2005 Suzuki Y, Tanaka M, Sohmiya M, Ichinose S, Omori A, Okamoto K. Identification of nitrated proteins in the normal rat brain using a proteomics approach Neurological Research. 27: 630-633. PMID 16157014 DOI: 10.1179/016164105X22039  0.305
2005 Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Chishti MA, Harigaya Y, ... ... Okamoto K, et al. Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. The American Journal of Pathology. 166: 521-31. PMID 15681835 DOI: 10.1016/S0002-9440(10)62274-2  0.35
2004 Yaguchi M, Fujita Y, Amari M, Takatama M, Al-Sarraj S, Leigh PN, Okamoto K. Morphological differences of intraneuronal ubiquitin-positive inclusions in the dentate gyrus and parahippocampal gyrus of motor neuron disease with dementia. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 24: 296-301. PMID 15641588 DOI: 10.1111/J.1440-1789.2004.00567.X  0.31
2004 Mizuno Y, Takeuchi T, Takatama M, Okamoto K. Expression of nestin in ballooned neurons in patients with Creutzfeldt-Jakob disease Neuroscience Letters. 366: 144-147. PMID 15276235 DOI: 10.1016/J.Neulet.2004.05.033  0.355
2003 Mizuno Y, Takeuchi T, Takatama M, Okamoto K. Expression of nestin in Purkinje cells in patients with Creutzfeldt-Jakob disease Neuroscience Letters. 352: 109-112. PMID 14625035 DOI: 10.1016/J.Neulet.2003.08.056  0.332
2003 Tanaka M, Ichiba T, Kondo S, Hirai S, Okamoto K. Cerebral blood flow and oxygen metabolism in patients with progressive dementia and amyotrophic lateral sclerosis Neurological Research. 25: 351-356. PMID 12870260 DOI: 10.1179/016164103101201670  0.371
2003 Mizuno Y, Hori S, Kakizuka A, Okamoto K. Vacuole-creating protein in neurodegenerative diseases in humans. Neuroscience Letters. 343: 77-80. PMID 12759168 DOI: 10.1016/S0304-3940(03)00280-5  0.345
2003 Yaguchi M, Hashizume Y, Yoshida M, K Gonatas N, Okamoto K. Reduction of the size of the Golgi apparatus of spinal anterior horn cells in patients with X-linked spinal and bulbar muscular atrophy. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 4: 17-21. PMID 12745613 DOI: 10.1080/14660820310006670  0.47
2003 Tan CF, Kakita A, Piao YS, Kikugawa K, Endo K, Tanaka M, Okamoto K, Takahashi H. Primary lateral sclerosis: a rare upper-motor-predominant form of amyotrophic lateral sclerosis often accompanied by frontotemporal lobar degeneration with ubiquitinated neuronal inclusions? Report of an autopsy case and a review of the literature. Acta Neuropathologica. 105: 615-20. PMID 12734667 DOI: 10.1007/S00401-003-0687-0  0.371
2003 Toyoshima Y, Piao YS, Tan CF, Morita M, Tanaka M, Oyanagi K, Okamoto K, Takahashi H. Pathological involvement of the motor neuron system and hippocampal formation in motor neuron disease-inclusion dementia. Acta Neuropathologica. 106: 50-6. PMID 12669241 DOI: 10.1007/S00401-003-0696-Z  0.363
2003 Yaguchi M, Okamoto K, Nakazato Y. Frontotemporal dementia with cerebral intraneuronal ubiquitin-positive inclusions but lacking lower motor neuron involvement. Acta Neuropathologica. 105: 81-5. PMID 12471466 DOI: 10.1007/S00401-002-0611-Z  0.38
2002 Uesugi M, Okamoto K, Tanaka M, Gonatas NK. Masses of phosphorylated neurofilaments are associated with abnormal golgi apparatus of anterior horn neurons of beta, beta'-iminodipropionitrile-intoxicated rats. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 22: 61-5. PMID 12075937 DOI: 10.1046/J.1440-1789.2002.00431.X  0.306
2002 Sakurai A, Okamoto K, Yaguchi M, Fujita Y, Mizuno Y, Nakazato Y, Gonatas NK. Pathology of the inferior olivary nucleus in patients with multiple system atrophy. Acta Neuropathologica. 103: 550-4. PMID 12012086 DOI: 10.1007/S00401-001-0500-X  0.331
2002 Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe M, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, et al. Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiology of Aging. 23: 363-70. PMID 11959397 DOI: 10.1016/S0197-4580(01)00309-8  0.317
2002 Fujita Y, Okamoto K, Sakurai A, Kusaka H, Aizawa H, Mihara B, Gonatas NK. The Golgi apparatus is fragmented in spinal cord motor neurons of amyotrophic lateral sclerosis with basophilic inclusions. Acta Neuropathologica. 103: 243-7. PMID 11907804 DOI: 10.1007/S004010100461  0.567
2001 Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M. Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. The Journal of Pathology. 194: 500-6. PMID 11523060 DOI: 10.1002/Path.897  0.335
2001 Hayashi S, Sakurai A, Amari M, Okamoto K. Pathological study of the diffuse myelin pallor in the anterolateral columns of the spinal cord in amyotrophic lateral sclerosis. Journal of the Neurological Sciences. 188: 3-7. PMID 11489277 DOI: 10.1016/S0022-510X(01)00531-7  0.303
2001 Takenoshita H, Shizuka-Ikeda M, Mitoma H, Song S, Harigaya Y, Igeta Y, Yaguchi M, Ishida K, Shoji M, Tanaka M, Mizusawa H, Okamoto K. Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. Journal of Neurology, Neurosurgery, and Psychiatry. 70: 386-9. PMID 11181864 DOI: 10.1136/Jnnp.70.3.386  0.477
2001 Takeda M, Tanaka T, Arai H, Sasaki H, Shoji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H. Basic and Clinical Studies on the Measurement of ?-amyloid(1?42)in Cerebrospinal Fluid as a Diagnostic Marker for Alzheimer's Disease and Related Disorders: Multi Center Study in Japan Psychogeriatrics. 1: 56-63. DOI: 10.1111/J.1479-8301.2001.Tb00073.X  0.301
2000 Shoji M, Kawarabayashi T, Matsubara E, Ikeda M, Ishiguro K, Harigaya Y, Okamoto K. Distribution of amyloid beta protein precursor in the Alzheimer's disease brain. Psychiatry and Clinical Neurosciences. 54: 45-54. PMID 15558879 DOI: 10.1046/J.1440-1819.2000.00636.X  0.341
2000 Takamine K, Okamoto K, Fujita Y, Sakurai A, Takatama M, Gonatas NK. The involvement of the neuronal Golgi apparatus and trans-Golgi network in the human olivary hypertrophy. Journal of the Neurological Sciences. 182: 45-50. PMID 11102638 DOI: 10.1016/S0022-510X(00)00447-0  0.301
2000 Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Okamoto K, Shoji M. Impaired neurotransmitter systems by Abeta amyloidosis in APPsw transgenic mice overexpressing amyloid beta protein precursor. Neuroscience Letters. 292: 155-8. PMID 11018300 DOI: 10.1016/S0304-3940(00)01443-9  0.31
2000 Sakurai A, Okamoto K, Fujita Y, Nakazato Y, Wakabayashi K, Takahashi H, Gonatas NK. Fragmentation of the Golgi apparatus of the ballooned neurons in patients with corticobasal degeneration and Creutzfeldt-Jakob disease. Acta Neuropathologica. 100: 270-4. PMID 10965796 DOI: 10.1007/S004010000182  0.313
2000 Aizawa H, Kimura T, Hashimoto K, Yahara O, Okamoto K, Kikuchi K. Basophilic cytoplasmic inclusions in a case of sporadic juvenile amyotrophic lateral sclerosis. Journal of the Neurological Sciences. 176: 109-13. PMID 10930592 DOI: 10.1016/S0022-510X(00)00321-X  0.345
2000 Fujita Y, Okamoto K, Sakurai A, Gonatas NK, Hirano A. Fragmentation of the Golgi apparatus of the anterior horn cells in patients with familial amyotrophic lateral sclerosis with SOD1 mutations and posterior column involvement. Journal of the Neurological Sciences. 174: 137-40. PMID 10727699 DOI: 10.1016/S0022-510X(00)00265-3  0.547
1999 Kanai M, Shizuka M, Urakami K, Matsubara E, Harigaya Y, Okamoto K, Shoji M. Apolipoprotein E4 accelerates dementia and increases cerebrospinal fluid tau levels in Alzheimer's disease. Neuroscience Letters. 267: 65-8. PMID 10400250 DOI: 10.1016/S0304-3940(99)00323-7  0.314
1998 Stieber A, Chen Y, Wei S, Mourelatos Z, Gonatas J, Okamoto K, Gonatas NK. The fragmented neuronal Golgi apparatus in amyotrophic lateral sclerosis includes the trans-Golgi-network: functional implications. Acta Neuropathologica. 95: 245-53. PMID 9542589 DOI: 10.1007/S004010050794  0.34
1997 STIEBER A, MOURELATOS Z, OKAMOTO K, GONATAS NK. FRAGMENTATION OF THE NEURONAL GOLGI APPARATUS IN FOUR ALS CASES WITH A PLETHORA OF BUNINA BODIES Journal of Neuropathology and Experimental Neurology. 56: 612. DOI: 10.1097/00005072-199705000-00178  0.33
1996 Okamoto K, Hirai S, Amari M, Sakurai A. Electron micrograph of ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with amyotrophic lateral sclerosis Neuropathology. 16: 112-116. DOI: 10.1111/J.1440-1789.1996.Tb00165.X  0.339
1996 Okamoto K, Watanabe M, Amari M, Hirai S. Membranous cytoplasmic bodies in the anterior horn neurons in two patients with amyotrophic lateral sclerosis Neuropathology. 16: 6-9. DOI: 10.1111/J.1440-1789.1996.Tb00147.X  0.351
1994 Tanaka M, Kondo S, Hirai S, Sun X, Yamagishi T, Okamoto K. Cerebral blood flow and oxygen metabolism in progressive dementia associated with amyotrophic lateral sclerosis. Journal of the Neurological Sciences. 120: 22-8. PMID 8289076 DOI: 10.1016/0022-510X(93)90019-U  0.33
1994 Okamoto K, Hirai S, Amari M, Watanabe M, Sakurai A. Bunina bodies in amyotrophic lateral sclerosis immunostained with rabbit anti-cystatin C serum. Neuroscience Letters. 162: 125-8. PMID 8121614 DOI: 10.1016/0304-3940(93)90576-7  0.357
1993 Okamoto K, Hirai S, Amari M, Iizuka T, Watanabe M, Murakami N, Takatama M. Oculomotor nuclear pathology in amyotrophic lateral sclerosis Acta Neuropathologica. 85: 458-462. PMID 8493857 DOI: 10.1007/Bf00230482  0.532
1992 Okamoto K, Hirai S, Yamazaki T, Sun XY, Nakazato Y. New ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with amyotrophic lateral sclerosis. Neuroscience Letters. 129: 233-6. PMID 1660578 DOI: 10.1016/0304-3940(91)90469-A  0.375
1992 Okamoto K, Hirai S, Lizuka T, Watanabe M. Fundamental Morphological Changes in Human Olivary Hypertrophy Pathology International. 42: 408-413. PMID 1502901 DOI: 10.1111/J.1440-1827.1992.Tb03245.X  0.32
1992 Okamoto K, Murakami N, Kusaka H, Yoshida M, Hashizume Y, Nakazato Y, Matsubara E, Hirai S. Ubiquitin-positive intraneuronal inclusions in the extramotor cortices of presenile dementia patients with motor neuron disease. Journal of Neurology. 239: 426-30. PMID 1333007 DOI: 10.1007/Bf00856806  0.696
1991 Okamoto K, Hirai S, Shoji M, Harigaya Y, Fukuda T. Widely distributed Bunina bodies and spheroids in a case of atypical sporadic amyotrophic lateral sclerosis. Acta Neuropathologica. 81: 349-53. PMID 2058368 DOI: 10.1007/Bf00305880  0.354
1991 Okamoto K, Hirai S, Ishiguro K, Kawarabayashi T, Takatama M. Light and electron microscopic and immunohistochemical observations of the Onuf's nucleus of amyotrophic lateral sclerosis Acta Neuropathologica. 81: 610-614. PMID 1882637 DOI: 10.1007/Bf00296370  0.353
1990 Okamoto K, Hirai S, Shoji M, Senoh Y, Yamazaki T. Axonal swellings in the corticospinal tracts in amyotrophic lateral sclerosis. Acta Neuropathologica. 80: 222-6. PMID 2202191 DOI: 10.1007/Bf00308929  0.3
1990 SOTOMATSU A, TANAKA M, OKAMOTO K, HIRAI S. A CASE OF SYRINGOMYELIA WITHOUT SENSORY DISTURBANCE-DEMONSTRATION OF A LARGE SYRINX BY MRI- The Kitakanto Medical Journal. 40: 343-347. DOI: 10.2974/Kmj1951.40.343  0.342
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