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Alessandro Bitto, Ph.D. - Publications

Affiliations: 
2013 Pathology Drexel University College of Medicine, Philadelphia, PA, United States 
Area:
Cell Biology
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bitto A, Grillo AS, Ito TK, Stanaway IB, Nguyen BMG, Ying K, Tung H, Smith K, Tran N, Velikanje G, Urfer SR, Snyder JM, Barton J, Sharma A, Kayser EB, et al. Acarbose suppresses symptoms of mitochondrial disease in a mouse model of Leigh syndrome. Nature Metabolism. 5: 955-967. PMID 37365290 DOI: 10.1038/s42255-023-00815-w  0.343
2022 Whitson JA, Johnson R, Wang L, Bammler TK, Imai SI, Zhang H, Fredrickson J, Latorre-Esteves E, Bitto A, MacCoss MJ, Rabinovitch PS. Age-related disruption of the proteome and acetylome in mouse hearts is associated with loss of function and attenuated by elamipretide (SS-31) and nicotinamide mononucleotide (NMN) treatment. Geroscience. PMID 35416576 DOI: 10.1007/s11357-022-00564-w  0.325
2021 Grillo AS, Bitto A, Kaeberlein M. The NDUFS4 Knockout Mouse: A Dual Threat Model of Childhood Mitochondrial Disease and Normative Aging. Methods in Molecular Biology (Clifton, N.J.). 2277: 143-155. PMID 34080150 DOI: 10.1007/978-1-0716-1270-5_10  0.318
2020 Whitson JA, Bitto A, Zhang H, Sweetwyne MT, Coig R, Bhayana S, Shankland EG, Wang L, Bammler TK, Mills KF, Imai SI, Conley KE, Marcinek DJ, Rabinovitch PS. SS-31 and NMN: Two paths to improve metabolism and function in aged hearts. Aging Cell. e13213. PMID 32779818 DOI: 10.1111/Acel.13213  0.366
2020 Johnson SC, Kayser EB, Bornstein R, Stokes J, Bitto A, Park KY, Pan A, Sun G, Raftery D, Kaeberlein M, Sedensky MM, Morgan PG. Regional metabolic signatures in the Ndufs4(KO) mouse brain implicate defective glutamate/α-ketoglutarate metabolism in mitochondrial disease. Molecular Genetics and Metabolism. PMID 32331968 DOI: 10.1016/J.Ymgme.2020.03.007  0.362
2019 Bitto A, Tung H, Ying K, Smith DL, Kayser E, Morgan PG, Sedensky MM, Kaeberlein M. Aging And Mitochondrial Disease: Shared Mechanisms And Therapies? Innovation in Aging. 3. DOI: 10.1093/Geroni/Igz038.1459  0.409
2019 Bitto A. Is Aging An Acquired Mitochondrial Disease Innovation in Aging. 3. DOI: 10.1093/Geroni/Igz038.1458  0.457
2018 Johnson SC, Martinez F, Bitto A, Gonzalez B, Tazaerslan C, Cohen C, Delaval L, Timsit J, Knebelmann B, Terzi F, Mahal T, Zhu Y, Morgan PG, Sedensky MM, Kaeberlein M, et al. mTOR inhibitors may benefit kidney transplant recipients with mitochondrial diseases. Kidney International. PMID 30471880 DOI: 10.1016/J.Kint.2018.08.038  0.452
2017 Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips JJ, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, ... ... Bitto A, et al. Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency. Frontiers in Genetics. 8: 221. PMID 29285026 DOI: 10.3389/Fgene.2017.00221  0.405
2017 Ito TK, Lu C, Khan J, Nguyen Q, Huang HZ, Kim D, Phillips J, Tan J, Lee Y, Nguyen T, Khessib S, Lim N, Mekvanich S, Oh J, Pineda VV, ... ... Bitto A, et al. Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency. Frontiers in Genetics. 8: 113. PMID 28919908 DOI: 10.3389/Fgene.2017.00113  0.405
2017 Bennett CF, Kwon JJ, Chen C, Russell J, Acosta K, Burnaevskiy N, Crane MM, Bitto A, Vander Wende H, Simko M, Pineda V, Rossner R, Wasko BM, Choi H, Chen S, et al. Transaldolase inhibition impairs mitochondrial respiration and induces a starvation-like longevity response in Caenorhabditis elegans. Plos Genetics. 13: e1006695. PMID 28355222 DOI: 10.1371/Journal.Pgen.1006695  0.482
2016 Bitto A, Ito TK, Pineda VV, Letexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, et al. Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice. Elife. 5. PMID 27549339 DOI: 10.7554/Elife.16351  0.331
2016 Bitto A, Ito TK, Pineda VV, LeTexier NJ, Huang HZ, Sutlief E, Tung H, Vizzini N, Chen B, Smith K, Meza D, Yajima M, Beyer RP, Kerr KF, Davis DJ, et al. Author response: Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice Elife. DOI: 10.7554/Elife.16351.031  0.308
2015 Bitto A, Wang AM, Bennett CF, Kaeberlein M. Biochemical Genetic Pathways that Modulate Aging in Multiple Species. Cold Spring Harbor Perspectives in Medicine. 5. PMID 26525455 DOI: 10.1101/Cshperspect.A025114  0.39
2015 Johnson SC, Yanos ME, Bitto A, Castanza A, Gagnidze A, Gonzalez B, Gupta K, Hui J, Jarvie C, Johnson BM, Letexier N, McCanta L, Sangesland M, Tamis O, Uhde L, et al. Dose-dependent effects of mTOR inhibition on weight and mitochondrial disease in mice. Frontiers in Genetics. 6: 247. PMID 26257774 DOI: 10.3389/Fgene.2015.00247  0.333
2014 Crowe EP, Nacarelli T, Bitto A, Lerner C, Sell C, Torres C. Detecting senescence: methods and approaches. Methods in Molecular Biology (Clifton, N.J.). 1170: 425-45. PMID 24906328 DOI: 10.1007/978-1-4939-0888-2_23  0.687
2014 Bitto A, Crowe EP, Lerner C, Torres C, Sell C. The senescence arrest program and the cell cycle. Methods in Molecular Biology (Clifton, N.J.). 1170: 145-54. PMID 24906313 DOI: 10.1007/978-1-4939-0888-2_8  0.699
2014 Bitto A, Lerner CA, Nacarelli T, Crowe E, Torres C, Sell C. P62/SQSTM1 at the interface of aging, autophagy, and disease. Age (Dordrecht, Netherlands). 36: 9626. PMID 24557832 DOI: 10.1007/S11357-014-9626-3  0.712
2013 Lerner C, Bitto A, Pulliam D, Nacarelli T, Konigsberg M, Van Remmen H, Torres C, Sell C. Reduced mammalian target of rapamycin activity facilitates mitochondrial retrograde signaling and increases life span in normal human fibroblasts. Aging Cell. 12: 966-77. PMID 23795962 DOI: 10.1111/Acel.12122  0.746
2013 Bitto A, Lerner CA, Van Remmen H, Konigsberg M, Pulliam D, Torres C, Sell C. Rapamycin improves mitochondrial homeostasis and delays the onset of senescence by altering p62/SQSTM1 dynamics Experimental Gerontology. 48: 692-693. DOI: 10.1016/J.Exger.2013.05.035  0.728
2013 Lerner C, Bitto A, Torres C, Sell C. Enhanced autophagy drives coordinate expression in nuclear and mitochondrial genomes Experimental Gerontology. 48: 686. DOI: 10.1016/J.Exger.2013.05.015  0.722
2012 Bhat R, Crowe EP, Bitto A, Moh M, Katsetos CD, Garcia FU, Johnson FB, Trojanowski JQ, Sell C, Torres C. Astrocyte senescence as a component of Alzheimer's disease. Plos One. 7: e45069. PMID 22984612 DOI: 10.1016/J.Exger.2013.05.042  0.544
2012 Sell C, Bitto A, Lerner C, Torres C. P03-17 IGF-I on the dark side: Negative consequences of IGF-I on mitochondrial homeostasis Growth Hormone & Igf Research. 22: S77. DOI: 10.1016/S1096-6374(12)60202-0  0.47
2011 Lerner C, Bitto A, Torres C, Sell C. IGF-I deficient mice show enhanced autophagy and increased mitochondrial content Experimental Gerontology. 46: 211-212. DOI: 10.1016/J.Exger.2010.11.023  0.731
2011 Bitto A, Lerner CA, Perez VE, Torres C, Sell C. IGF-I signaling affects long-term viability of primary human fibroblasts by impairing mitophagy of dysfunctional mitochondria Experimental Gerontology. 46: 209. DOI: 10.1016/J.Exger.2010.11.016  0.714
2010 Bitto A, Lerner C, Torres C, Roell M, Malaguti M, Perez V, Lorenzini A, Hrelia S, Ikeno Y, Matzko ME, McCarter R, Sell C. Long-term IGF-I exposure decreases autophagy and cell viability. Plos One. 5: e12592. PMID 20830296 DOI: 10.1371/Journal.Pone.0012592  0.737
2010 Bitto A, Sell C, Crowe E, Lorenzini A, Malaguti M, Hrelia S, Torres C. Stress-induced senescence in human and rodent astrocytes. Experimental Cell Research. 316: 2961-8. PMID 20620137 DOI: 10.1016/J.Exger.2010.11.028  0.547
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