cached image

Virginia Man-Yee Lee, PhD, MBA - Related publications

Affiliations: 
Pathology University of Pennsylvania, Philadelphia, PA, United States 
Area:
tau, dementia, neurodegeneration
Website:
http://www.med.upenn.edu/cndr/VMYLeebio.shtml
NOTE: We are testing a new system for identifying relevant work based on semantic analysis that identifies similarities between recently published papers and the current author's publications. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches.
50 most relevant papers in past 60 days:
Year Citation  Score
2021 Quint WH, Matečko-Burmann I, Schilcher I, Löffler T, Schöll M, Burmann BM, Vogels T. Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein. Journal of Alzheimer's Disease : Jad. PMID 33579845 DOI: 10.3233/JAD-201334   
2021 Li S, Yi Y, Cui K, Zhang Y, Chen Y, Han D, Sun L, Zhang X, Chen F, Zhang Y, Yang Y. A Single-Chain Variable Fragment Antibody Inhibits Aggregation of Phosphorylated Tau and Ameliorates Tau Toxicity in vitro and in vivo. Journal of Alzheimer's Disease : Jad. PMID 33459708 DOI: 10.3233/JAD-191266   
2021 McGrowder DA, Miller F, Vaz K, Nwokocha C, Wilson-Clarke C, Anderson-Cross M, Brown J, Anderson-Jackson L, Williams L, Latore L, Thompson R, Alexander-Lindo R. Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: Current Evidence and Future Perspectives. Brain Sciences. 11. PMID 33578866 DOI: 10.3390/brainsci11020215   
2021 Martínez-Maldonado A, Ontiveros-Torres MÁ, Harrington CR, Montiel-Sosa JF, Prandiz RG, Bocanegra-López P, Sorsby-Vargas AM, Bravo-Muñoz M, Florán-Garduño B, Villanueva-Fierro I, Perry G, Garcés-Ramírez L, de la Cruz F, Martínez-Robles S, Pacheco-Herrero M, et al. Molecular Processing of Tau Protein in Progressive Supranuclear Palsy: Neuronal and Glial Degeneration. Journal of Alzheimer's Disease : Jad. PMID 33459640 DOI: 10.3233/JAD-201139   
2021 Chen Y, Zhao S, Fan Z, Li Z, Zhu Y, Shen T, Li K, Yan Y, Tian J, Liu Z, Zhang B. Metformin attenuates plaque-associated tau pathology and reduces amyloid-β burden in APP/PS1 mice. Alzheimer's Research & Therapy. 13: 40. PMID 33563332 DOI: 10.1186/s13195-020-00761-9   
2021 Phan LMT, Hoang TX, Vo TAT, Pham HL, Le HTN, Chinnadayyala SR, Kim JY, Lee SM, Cho WW, Kim YH, Choi SH, Cho S. Nanomaterial-based Optical and Electrochemical Biosensors for Amyloid beta and Tau: Potential for early diagnosis of Alzheimer's Disease. Expert Review of Molecular Diagnostics. PMID 33560154 DOI: 10.1080/14737159.2021.1887732   
2021 Hartnell IJ, Blum D, Nicoll JAR, Dorothee G, Boche D. Glial cells and adaptive immunity in frontotemporal dementia with tau pathology. Brain : a Journal of Neurology. PMID 33527991 DOI: 10.1093/brain/awaa457   
2021 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM. Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease. Acta Neuropathologica. PMID 33609158 DOI: 10.1007/s00401-021-02263-w   
2021 Carosi JM, Denton D, Kumar S, Sargeant TJ. Retromer dysfunction at the nexus of tauopathies. Cell Death and Differentiation. PMID 33473181 DOI: 10.1038/s41418-020-00727-2   
2021 Ulm BS, Borchelt DR, Moore BD. Remodeling Alzheimer-amyloidosis models by seeding. Molecular Neurodegeneration. 16: 8. PMID 33588898 DOI: 10.1186/s13024-021-00429-4   
2021 Hao J, Tang Y, Liu X, Yao E. Inhibiting PI3K leads to glucose metabolism disturbance in default mode network. Brain Research Bulletin. PMID 33626336 DOI: 10.1016/j.brainresbull.2021.02.020   
2021 Chang CW, Shao E, Mucke L. Tau: Enabler of diverse brain disorders and target of rapidly evolving therapeutic strategies. Science (New York, N.Y.). 371. PMID 33632820 DOI: 10.1126/science.abb8255   
2021 Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Communications. 3: fcab011. PMID 33644757 DOI: 10.1093/braincomms/fcab011   
2021 Bengoa-Vergniory N, Velentza-Almpani E, Silva AM, Scott C, Vargas-Caballero M, Sastre M, Wade-Martins R, Alegre-Abarrategui J. Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease. Acta Neuropathologica Communications. 9: 18. PMID 33509301 DOI: 10.1186/s40478-020-01117-y   
2021 Jablonski AM, Warren L, Usenovic M, Zhou H, Sugam J, Parmentier-Batteur S, Voleti B. Astrocytic expression of the Alzheimer's disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models. Scientific Reports. 11: 3438. PMID 33564035 DOI: 10.1038/s41598-021-82901-1   
2021 Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, et al. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Science Translational Medicine. 13. PMID 33472953 DOI: 10.1126/scitranslmed.abc0655   
2021 Goedert M, Spillantini MG, Falcon B, Zhang W, Newell KL, Hasegawa M, Scheres SHW, Ghetti B. Tau Protein and Frontotemporal Dementias. Advances in Experimental Medicine and Biology. 1281: 177-199. PMID 33433876 DOI: 10.1007/978-3-030-51140-1_12   
2021 Nguyen PH, Ramamoorthy A, Sahoo BR, Zheng J, Faller P, Straub JE, Dominguez L, Shea JE, Dokholyan NV, De Simone A, Ma B, Nussinov R, Najafi S, Ngo ST, Loquet A, et al. Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis. Chemical Reviews. PMID 33543942 DOI: 10.1021/acs.chemrev.0c01122   
2021 Kim S, Kim K, Nho K, Myung W, Won HH. Shared Genetic Background Between Cerebrospinal Fluid Biomarkers and Risk for Alzheimer's Disease: A Two-Sample Mendelian Randomization Study. Journal of Alzheimer's Disease : Jad. PMID 33646147 DOI: 10.3233/JAD-200671   
2021 Zhang G, Wu J, Huang C, Cheng J, Su Z, Zhu Z, Yang X, Guo B, Wu L, Zhang Z, Zhang G, Chen H, Sun Y, Wang Y. The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer's Disease. Journal of Molecular Neuroscience : Mn. PMID 33403592 DOI: 10.1007/s12031-020-01762-x   
2021 Cicognola C, Hansson O, Scheltens P, Kvartsberg H, Zetterberg H, Teunissen CE, Blennow K. Cerebrospinal fluid N-224 tau helps discriminate Alzheimer's disease from subjective cognitive decline and other dementias. Alzheimer's Research & Therapy. 13: 38. PMID 33557920 DOI: 10.1186/s13195-020-00756-6   
2021 Jellinger KA. Pathobiological Subtypes of Alzheimer Disease. Dementia and Geriatric Cognitive Disorders. 1-13. PMID 33429401 DOI: 10.1159/000508625   
2021 Moscoso A, Grothe MJ, Ashton NJ, Karikari TK, Lantero Rodríguez J, Snellman A, Suárez-Calvet M, Blennow K, Zetterberg H, Schöll M, . Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease. Jama Neurology. PMID 33427873 DOI: 10.1001/jamaneurol.2020.4986   
2021 Zhu L, Sun L, Sun L, Xiao S. Case of early-onset Alzheimer's disease with atypical manifestation. General Psychiatry. 34: e100283. PMID 33585790 DOI: 10.1136/gpsych-2020-100283   
2021 Di J, Siddique I, Li Z, Malki G, Hornung S, Dutta S, Hurst I, Ishaaya E, Wang A, Tu S, Boghos A, Ericsson I, Klärner FG, Schrader T, Bitan G. The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. Alzheimer's Research & Therapy. 13: 6. PMID 33397489 DOI: 10.1186/s13195-020-00743-x   
2021 Aragão Gomes L, Uytterhoeven V, Lopez-Sanmartin D, Tomé SO, Tousseyn T, Vandenberghe R, Vandenbulcke M, von Arnim CAF, Verstreken P, Thal DR. Maturation of neuronal AD-tau pathology involves site-specific phosphorylation of cytoplasmic and synaptic tau preceding conformational change and fibril formation. Acta Neuropathologica. 141: 173-192. PMID 33427938 DOI: 10.1007/s00401-020-02251-6   
2021 Xu H, O'Reilly M, Gibbons GS, Changolkar L, McBride JD, Riddle DM, Zhang B, Stieber A, Nirschl J, Kim SJ, Hoxha KH, Brunden KR, Schellenberg GD, Trojanowski JQ, Lee VM. In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics. Acta Neuropathologica. PMID 33385254 DOI: 10.1007/s00401-020-02253-4   
2021 Malafaia D, Albuquerque HMT, Silva AMS. Amyloid-β and tau aggregation dual-inhibitors: A synthetic and structure-activity relationship focused review. European Journal of Medicinal Chemistry. 214: 113209. PMID 33548635 DOI: 10.1016/j.ejmech.2021.113209   
2021 Alausa A, Ogundepo S, Olaleke B, Adeyemi R, Olatinwo M, Ismail A. Chinese nutraceuticals and physical activity; their role in neurodegenerative tauopathies. Chinese Medicine. 16: 1. PMID 33407732 DOI: 10.1186/s13020-020-00418-7   
2021 Jie CVML, Treyer V, Schibli R, Mu L. Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). 14. PMID 33573211 DOI: 10.3390/ph14020110   
2021 Wu R, Gu J, Zhou D, Tung YC, Jin N, Chu D, Hu W, Wegiel J, Gong CX, Iqbal K, Liu F. Seeding-Competent Tau in Gray Matter Versus White Matter of Alzheimer's Disease Brain. Journal of Alzheimer's Disease : Jad. PMID 33459649 DOI: 10.3233/JAD-201290   
2021 Neff RA, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A, Castranio EL, Tcw J, Ho L, Goate A, Fossati V, et al. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets. Science Advances. 7. PMID 33523961 DOI: 10.1126/sciadv.abb5398   
2021 Li L, Shi R, Gu J, Tung YC, Zhou Y, Zhou D, Wu R, Chu D, Jin N, Deng K, Xu J, Gong CX, Iqbal K, Liu F. Alzheimer's disease brain contains tau fractions with differential prion-like activities. Acta Neuropathologica Communications. 9: 28. PMID 33597014 DOI: 10.1186/s40478-021-01127-4   
2021 Takaichi Y, Chambers JK, Takahashi K, Soeda Y, Koike R, Katsumata E, Kita C, Matsuda F, Haritani M, Takashima A, Nakayama H, Uchida K. Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus). Acta Neuropathologica Communications. 9: 10. PMID 33413691 DOI: 10.1186/s40478-020-01104-3   
2021 Tsoy E, Strom A, Iaccarino L, Erlhoff SJ, Goode CA, Rodriguez AM, Rabinovici GD, Miller BL, Kramer JH, Rankin KP, La Joie R, Possin KL. Detecting Alzheimer's disease biomarkers with a brief tablet-based cognitive battery: sensitivity to Aβ and tau PET. Alzheimer's Research & Therapy. 13: 36. PMID 33557905 DOI: 10.1186/s13195-021-00776-w   
2021 Park J, Choi H, Kim YD, Kim SH, Kim Y, Gwon Y, Lee DY, Park SH, Heo WD, Jung YK. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. Molecular Psychiatry. PMID 33452442 DOI: 10.1038/s41380-020-01003-y   
2021 Patrick E, Olah M, Taga M, Klein HU, Xu J, White CC, Felsky D, Agrawal S, Gaiteri C, Chibnik LB, Mostafavi S, Schneider JA, Bennett DA, Bradshaw EM, De Jager PL. A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies. Translational Psychiatry. 11: 50. PMID 33446646 DOI: 10.1038/s41398-020-01175-9   
2021 Litvinchuk A, Huynh TV, Shi Y, Jackson RJ, Finn MB, Manis M, Francis CM, Tran A, Sullivan PM, Ulrich JD, Hyman BT, Cole T, Holtzman DM. ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model. Annals of Neurology. PMID 33550655 DOI: 10.1002/ana.26043   
2021 Kelly JW. Does protein aggregation drive postmitotic tissue degeneration? Science Translational Medicine. 13. PMID 33472954 DOI: 10.1126/scitranslmed.aax0914   
2021 Seemiller J, Bischof GN, Hoenig MC, Tahmasian M, van Eimeren T, Drzezga A, . Indication of retrograde tau spreading along Braak stages and functional connectivity pathways. European Journal of Nuclear Medicine and Molecular Imaging. PMID 33462630 DOI: 10.1007/s00259-020-05183-1   
2021 Klein J, Yan X, Johnson A, Tomljanovic Z, Zou J, Polly K, Honig LS, Brickman AM, Stern Y, Devanand DP, Lee S, Kreisl WC. Olfactory Impairment is Related to Tau Pathology and Neuroinflammation in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 33646153 DOI: 10.3233/JAD-201149   
2021 James OG, Linares AR, Hellegers C, Doraiswamy PM, Wong TZ. Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series. Clinical Nuclear Medicine. PMID 33443955 DOI: 10.1097/RLU.0000000000003493   
2021 Tedeschi DV, da Cunha AF, Cominetti MR, Pedroso RV. Efficacy of gene therapy to restore cognition in Alzheimer's disease: a systematic review. Current Gene Therapy. PMID 33494678 DOI: 10.2174/1566523221666210120091146   
2021 Giovinazzo D, Bursac B, Sbodio JI, Nalluru S, Vignane T, Snowman AM, Albacarys LM, Sedlak TW, Torregrossa R, Whiteman M, Filipovic MR, Snyder SH, Paul BD. Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3β and inhibiting Tau hyperphosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33431651 DOI: 10.1073/pnas.2017225118   
2021 Keshavan A, Wellington H, Chen Z, Khatun A, Chapman M, Hart M, Cash DM, Coath W, Parker TD, Buchanan SM, Keuss SE, Harris MJ, Murray-Smith H, Heslegrave A, Fox NC, et al. Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12131. PMID 33598527 DOI: 10.1002/dad2.12131   
2021 Martinisi A, Flach M, Sprenger F, Frank S, Tolnay M, Winkler DT. Severe oligomeric tau toxicity can be reversed without long-term sequelae. Brain : a Journal of Neurology. PMID 33484116 DOI: 10.1093/brain/awaa445   
2021 Liu X, Wang K, Wei X, Xie T, Lv B, Zhou Q, Wang X. Interaction of NF-κB and Wnt/β-catenin Signaling Pathways in Alzheimer's Disease and Potential Active Drug Treatments. Neurochemical Research. PMID 33523396 DOI: 10.1007/s11064-021-03227-y   
2021 Salvadó G, Grothe MJ, Groot C, Moscoso A, Schöll M, Gispert JD, Ossenkoppele R, . Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia. European Journal of Nuclear Medicine and Molecular Imaging. PMID 33521872 DOI: 10.1007/s00259-021-05192-8   
2021 Ahmad SS, Khalid M, Kamal MA, Younis K. Study of Nutraceuticals and Phytochemicals for the Management of Alzheimer's Disease: A Review. Current Neuropharmacology. PMID 33588732 DOI: 10.2174/1570159X19666210215122333   
2021 Grober E, Qi Q, Kuo L, Hassenstab J, Perrin RJ, Lipton RB. Stages of Objective Memory Impairment Predict Alzheimer's Disease Neuropathology: Comparison with the Clinical Dementia Rating Scale-Sum of Boxes. Journal of Alzheimer's Disease : Jad. PMID 33492286 DOI: 10.3233/JAD-200946