Yasuo Ihara, MD - Publications

Affiliations: 
Neuropathology University of Tokyo, Bunkyō-ku, Tōkyō-to, Japan 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=59
Website:
http://books.google.com/books?id=QPqCvP0wFjUC&pg=PA209&lpg=PA209&dq=Yasuo+Ihara+tokyo&source=bl&ots=pitZ1PpZ6j&sig=DXK34KdhupZLLkBcCLSrRVGltd8&hl=en&ei=5XNCTfX4HcP78Aai0cyLAg&sa=X&oi=

181 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Kakuda N, Takami M, Okochi M, Kasuga K, Ihara Y, Ikeuchi T. Switched Aβ43 generation in familial Alzheimer's disease with presenilin 1 mutation. Translational Psychiatry. 11: 558. PMID 34728605 DOI: 10.1038/s41398-021-01684-1  0.32
2020 Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S, Ihara Y. γ-Secretase activity is associated with Braak Senile Plaque stages. The American Journal of Pathology. PMID 32201261 DOI: 10.1016/J.Ajpath.2020.02.009  0.424
2019 Kubo A, Ueda S, Yamane A, Wada-Kakuda S, Narita M, Matsuyama M, Nomori A, Takashima A, Kato T, Onodera O, Goto M, Ito M, Tomiyama T, Mori H, Murayama S, ... Ihara Y, et al. Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31235644 DOI: 10.1523/JNEUROSCI.2845-18.2019  0.719
2019 Ikegawa M, Nirasawa T, Kakuda N, Miyasaka T, Kuzuhara Y, Murayama S, Ihara Y. Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry. Journal of Visualized Experiments : Jove. PMID 30907869 DOI: 10.3791/57645  0.428
2018 Kubo A, Misonou H, Matsuyama M, Nomori A, Wada-Kakuda S, Takashima A, Kawata M, Murayama S, Ihara Y, Miyasaka T. Distribution of endogenous normal tau in the mouse brain. The Journal of Comparative Neurology. PMID 30408165 DOI: 10.1002/cne.24577  0.718
2018 Miyasaka T, Shinzaki Y, Yoshimura S, Yoshina S, Kage-Nakadai E, Mitani S, Ihara Y. Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in Models of Tauopathy. Frontiers in Neuroscience. 12: 415. PMID 29973863 DOI: 10.3389/fnins.2018.00415  0.444
2017 Kakuda N, Miyasaka T, Iwasaki N, Nirasawa T, Wada-Kakuda S, Takahashi-Fujigasaki J, Murayama S, Ihara Y, Ikegawa M. Distinct deposition of amyloid-β species in brains with Alzheimer's disease pathology visualized with MALDI imaging mass spectrometry. Acta Neuropathologica Communications. 5: 73. PMID 29037261 DOI: 10.1186/s40478-017-0477-x  0.434
2017 Tagami S, Yanagida K, Kodama TS, Takami M, Mizuta N, Oyama H, Nishitomi K, Chiu YW, Okamoto T, Ikeuchi T, Sakaguchi G, Kudo T, Matsuura Y, Fukumori A, Takeda M, ... Ihara Y, et al. Semagacestat Is a Pseudo-Inhibitor of γ-Secretase. Cell Reports. 21: 259-273. PMID 28978478 DOI: 10.1016/j.celrep.2017.09.032  0.382
2016 Higashide H, Ishihara S, Nobuhara M, Ihara Y, Funamoto S. Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization. Journal of Neurochemistry. PMID 28032911 DOI: 10.1111/jnc.13942  0.429
2016 Miyasaka T, Xie C, Yoshimura S, Shinzaki Y, Yoshina S, Kage-Nakadai E, Mitani S, Ihara Y. Curcumin improves tau-induced neuronal dysfunction of nematodes. Neurobiology of Aging. 39: 69-81. PMID 26923403 DOI: 10.1016/j.neurobiolaging.2015.11.004  0.437
2015 Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, et al. Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. Nature Communications. 6: 10216. PMID 26671725 DOI: 10.1038/ncomms10216  0.456
2015 Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S. The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells. Acta Neuropathologica Communications. 3: 66. PMID 26531305 DOI: 10.1186/s40478-015-0247-6  0.336
2015 Xie C, Soeda Y, Shinzaki Y, In Y, Tomoo K, Ihara Y, Miyasaka T. Identification of key amino acids responsible for the distinct aggregation properties of microtubule-associated protein 2 and tau. Journal of Neurochemistry. PMID 26134402 DOI: 10.1111/jnc.13228  0.412
2015 Shimura M, Matsushita Y, Ikezaki K, Ichiyanagi K, Miyasaka T, Hiroshi S, Ihara Y, Sasaki YC. Anomalous Stiffness Changes of Tau Protein in X-ray Single Molecule Observations Biophysical Journal. 108: 62a. DOI: 10.1016/j.bpj.2014.11.370  0.387
2014 Miyashita A, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kitamura N, Akazawa K, Kakita A, Takahashi H, Murayama S, Ihara Y, Ikeuchi T, et al. Genes associated with the progression of neurofibrillary tangles in Alzheimer's disease. Translational Psychiatry. 4: e396. PMID 26126179 DOI: 10.1038/tp.2014.35  0.407
2014 Saito Y, Miyasaka T, Hatsuta H, Takahashi-Niki K, Hayashi K, Mita Y, Kusano-Arai O, Iwanari H, Ariga H, Hamakubo T, Yoshida Y, Niki E, Murayama S, Ihara Y, Noguchi N. Immunostaining of oxidized DJ-1 in human and mouse brains. Journal of Neuropathology and Experimental Neurology. 73: 714-28. PMID 24918637 DOI: 10.1097/NEN.0000000000000087  0.327
2014 Xie C, Miyasaka T, Yoshimura S, Hatsuta H, Yoshina S, Kage-Nakadai E, Mitani S, Murayama S, Ihara Y. The homologous carboxyl-terminal domains of microtubule-associated protein 2 and TAU induce neuronal dysfunction and have differential fates in the evolution of neurofibrillary tangles. Plos One. 9: e89796. PMID 24587039 DOI: 10.1371/journal.pone.0089796  0.396
2014 Matsumura N, Takami M, Okochi M, Wada-Kakuda S, Fujiwara H, Tagami S, Funamoto S, Ihara Y, Morishima-Kawashima M. γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment. The Journal of Biological Chemistry. 289: 5109-21. PMID 24375443 DOI: 10.1074/jbc.M113.510131  0.352
2014 Shimura M, Matsushita Y, Ikezaki K, Miysasaka T, Ichiyanagi K, Sekiguchi H, Ihara Y, Sasaki Y. 1P082 X-ray Single Molecule Observations of Phosphorylated Tau protein's structural fluctuations(01E. Protein : Measurement & Analysis,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)) Seibutsu Butsuri. 54: S154. DOI: 10.2142/biophys.54.S154_4  0.305
2014 Miyashita A, Kuwano R, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kakita A, Takahashi H, Murayama S, Ihara Y, Ikeuchi T. Genes Associated With The Progression Of Neurofibrillary Tangles In Alzheimer'S Disease Brains Alzheimers & Dementia. 10: 475. DOI: 10.1016/J.Jalz.2014.05.687  0.389
2014 Sasaki YC, Shimura M, Matsushita Y, Ichiyanagi K, Sekiguchi H, Miyasaka T, Ihara Y. Structural Fluctuations and Aggregations of Tau Proteins from X-Ray Single Molecule Observations Biophysical Journal. 106: 58a. DOI: 10.1016/j.bpj.2013.11.399  0.365
2013 Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase. Nature Communications. 4: 2529. PMID 24108142 DOI: 10.1038/ncomms3529  0.313
2013 Kang MS, Baek SH, Chun YS, Moore AZ, Landman N, Berman D, Yang HO, Morishima-Kawashima M, Osawa S, Funamoto S, Ihara Y, Di Paolo G, Park JH, Chung S, Kim TW. Modulation of lipid kinase PI4KIIα activity and lipid raft association of presenilin 1 underlies γ-secretase inhibition by ginsenoside (20S)-Rg3. The Journal of Biological Chemistry. 288: 20868-82. PMID 23723072 DOI: 10.1074/Jbc.M112.445734  0.369
2013 Okochi M, Tagami S, Yanagida K, Takami M, Kodama TS, Mori K, Nakayama T, Ihara Y, Takeda M. γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43. Cell Reports. 3: 42-51. PMID 23291095 DOI: 10.1016/j.celrep.2012.11.028  0.351
2013 Kakuda N, Akazawa K, Hatsuta H, Murayama S, Ihara Y. Suspected limited efficacy of γ-secretase modulators. Neurobiology of Aging. 34: 1101-4. PMID 23058852 DOI: 10.1016/j.neurobiolaging.2012.08.017  0.417
2012 Ihara Y, Morishima-Kawashima M, Nixon R. The ubiquitin-proteasome system and the autophagic-lysosomal system in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 2. PMID 22908190 DOI: 10.1101/cshperspect.a006361  0.391
2012 Kakuda N, Shoji M, Arai H, Furukawa K, Ikeuchi T, Akazawa K, Takami M, Hatsuta H, Murayama S, Hashimoto Y, Miyajima M, Arai H, Nagashima Y, Yamaguchi H, Kuwano R, ... ... Ihara Y, et al. Altered γ-secretase activity in mild cognitive impairment and Alzheimer's disease. Embo Molecular Medicine. 4: 344-52. PMID 22354516 DOI: 10.1002/emmm.201200214  0.378
2012 Kuwano R, Miyashita A, Koike A, Nishida N, Tokunaga K, Yamamoto K, Ihara Y, Kim J, Pericak-Vance M, Farrer L, Schellenberg G. Genome-wide association study of Alzheimer's disease: A collaborative genetic study on Alzheimer's disease with Japan, Korea and the Alzheimer's Disease Genetics Consortium Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.2111  0.334
2011 Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Potent amyloidogenicity and pathogenicity of Aβ43. Nature Neuroscience. 14: 1023-32. PMID 21725313 DOI: 10.1038/nn.2858  0.395
2011 Takamura A, Kawarabayashi T, Yokoseki T, Shibata M, Morishima-Kawashima M, Saito Y, Murayama S, Ihara Y, Abe K, Shoji M, Michikawa M, Matsubara E. Dissociation of β-amyloid from lipoprotein in cerebrospinal fluid from Alzheimer's disease accelerates β-amyloid-42 assembly. Journal of Neuroscience Research. 89: 815-21. PMID 21394760 DOI: 10.1002/Jnr.22615  0.409
2011 Kuwano R, Miyashita A, Koike A, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Ihara Y. Genome-wide association study of late-onset Alzheimer's disease in Japanese Neuroscience Research. 71: e290. DOI: 10.1016/j.neures.2011.07.1266  0.319
2010 Mori K, Okochi M, Tagami S, Nakayama T, Yanagida K, Kodama TS, Tatsumi S, Fujii K, Tanimukai H, Hashimoto R, Morihara T, Tanaka T, Kudo T, Funamoto S, Ihara Y, et al. The production ratios of AICDε51 and Aβ42 by intramembrane proteolysis of βAPP do not always change in parallel. Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society. 10: 117-23. PMID 20860566 DOI: 10.1111/j.1479-8301.2010.00330.x  0.342
2010 Miyasaka T, Yoshimura S, Saka A, Shinzaki Y, Yoshina S, Kage-Nakadai E, Mitani S, Ihara Y. P4-026: Curcumin Improves Tau-mediated Neuronal Dysfunction in Nematode Alzheimer's & Dementia. 6: e27-e28. DOI: 10.1016/j.jalz.2010.08.086  0.307
2010 Miyashita A, Saito Y, Hatsuta H, Tsukie T, Kakita A, Iijima R, Ogishima S, Tanaka H, Takahashi H, Murayama S, Ihara Y, Kuwano R. P1-080: Gene expression profiling of postmortem brain tissues with Alzheimer's disease Alzheimer's & Dementia. 6: S197-S197. DOI: 10.1016/J.Jalz.2010.05.628  0.34
2009 Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y. gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 13042-52. PMID 19828817 DOI: 10.1523/JNEUROSCI.2362-09.2009  0.401
2008 Osawa S, Funamoto S, Nobuhara M, Wada-Kakuda S, Shimojo M, Yagishita S, Ihara Y. Phosphoinositides suppress gamma-secretase in both the detergent-soluble and -insoluble states. The Journal of Biological Chemistry. 283: 19283-92. PMID 18480063 DOI: 10.1074/jbc.M705954200  0.33
2008 Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A. Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta. The Journal of Biological Chemistry. 283: 16488-96. PMID 18430735 DOI: 10.1074/Jbc.M801279200  0.43
2008 Yagishita S, Morishima-Kawashima M, Ishiura S, Ihara Y. Abeta46 is processed to Abeta40 and Abeta43, but not to Abeta42, in the low density membrane domains. The Journal of Biological Chemistry. 283: 733-8. PMID 18024430 DOI: 10.1074/jbc.M707103200  0.408
2008 Miyashita A, Saito Y, Kakita A, Ogishima S, Tanaka H, Takahashi H, Murayama S, Ihara Y, Kuwano R. P3-243: Gene expression profiling of postmortem brain tissues affected by Alzheimer's disease Alzheimer's & Dementia. 4: T592-T592. DOI: 10.1016/J.Jalz.2008.05.1810  0.341
2007 Ihara Y. [Overview on Alzheimer's disease]. Rinshå Shinkeigaku = Clinical Neurology. 47: 902-4. PMID 18210830  0.304
2007 Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. The Journal of Biological Chemistry. 282: 33985-93. PMID 17911105 DOI: 10.1074/Jbc.M705248200  0.366
2007 Morishima-Kawashima M, Han X, Tanimura Y, Hamanaka H, Kobayashi M, Sakurai T, Yokoyama M, Wada K, Nukina N, Fujita SC, Ihara Y. Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domains. Journal of Neurochemistry. 101: 949-58. PMID 17472586 DOI: 10.1111/J.1471-4159.2006.04400.X  0.41
2006 Ihara Y. Neurofibrillary tangles/paired helical filaments (1981-83). Journal of Alzheimer's Disease : Jad. 9: 209-17. PMID 16914860 DOI: 10.3233/Jad-2006-9S324  0.317
2006 Iwatsubo T, Ihara Y, Kanazawa I. Alzheimer disease research in Japan: public funding. Nature Medicine. 12: 778-9. PMID 16829946 DOI: 10.1038/nm0706-778  0.477
2006 Kuwano R, Miyashita A, Arai H, Asada T, Imagawa M, Shoji M, Higuchi S, Urakami K, Kakita A, Takahashi H, Tsukie T, Toyabe S, Akazawa K, Kanazawa I, Ihara Y, et al. Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's disease. Human Molecular Genetics. 15: 2170-82. PMID 16740596 DOI: 10.1093/hmg/ddl142  0.333
2006 Kakuda N, Funamoto S, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. The Journal of Biological Chemistry. 281: 14776-86. PMID 16595682 DOI: 10.1074/jbc.M513453200  0.425
2006 Yagishita S, Morishima-Kawashima M, Tanimura Y, Ishiura S, Ihara Y. DAPT-induced intracellular accumulations of longer amyloid beta-proteins: further implications for the mechanism of intramembrane cleavage by gamma-secretase. Biochemistry. 45: 3952-60. PMID 16548522 DOI: 10.1021/bi0521846  0.416
2006 Funamoto S, Kakuda N, Yagishita S, Takami M, Osawa S, Dohmae N, Ihara Y. P3-405: Equimolar production of Abeta and AICD from C99 by gamma-secretase Alzheimer's & Dementia. 2: S495-S495. DOI: 10.1016/j.jalz.2006.05.1676  0.308
2005 Miyasaka T, Ding Z, Gengyo-Ando K, Oue M, Yamaguchi H, Mitani S, Ihara Y. Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiology of Disease. 20: 372-83. PMID 16242642 DOI: 10.1016/j.nbd.2005.03.017  0.352
2005 Miyasaka T, Watanabe A, Saito Y, Murayama S, Mann DM, Yamazaki M, Ravid R, Morishima-Kawashima M, Nagashima K, Ihara Y. Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads. Journal of Neuropathology and Experimental Neurology. 64: 665-74. PMID 16106214 DOI: 10.1097/01.Jnen.0000173890.79058.1D  0.448
2005 Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawashima M, Ihara Y. Blocking the cleavage at midportion between gamma- and epsilon-sites remarkably suppresses the generation of amyloid beta-protein. Febs Letters. 579: 2907-12. PMID 15890346 DOI: 10.1016/j.febslet.2005.04.037  0.425
2005 Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. The Journal of Biological Chemistry. 280: 19070-7. PMID 15764596 DOI: 10.1074/jbc.M501130200  0.389
2005 Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Murayama S, Ihara Y. Independent accumulations of tau and amyloid beta-protein in the human entorhinal cortex. Neurology. 64: 687-92. PMID 15728293 DOI: 10.1212/01.Wnl.0000151958.79884.86  0.444
2005 Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y. Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 165-79. PMID 15676027 DOI: 10.1111/J.1365-2443.2005.00827.X  0.342
2005 Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y. Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 436-45. PMID 15647487 DOI: 10.1523/JNEUROSCI.1575-04.2005  0.426
2005 Ivy GO, Ihara Y, Kitani K. The protease inhibitor leupeptin induces several signs of aging in brain, retina and internal organs of young rats. Archives of Gerontology and Geriatrics. 12: 119-31. PMID 15374443 DOI: 10.1016/0167-4943(91)90023-J  0.323
2005 Ihara Y. Research on Alzheimer's disease in Japan: a personal view on history and present status. Archives of Gerontology and Geriatrics. 19: 89-104. PMID 15374277 DOI: 10.1016/0167-4943(94)90032-9  0.487
2004 Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y. Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42. Biochemistry. 43: 13532-40. PMID 15491160 DOI: 10.1021/bi049399k  0.429
2004 Watanabe A, Hong WK, Dohmae N, Takio K, Morishima-Kawashima M, Ihara Y. Molecular aging of tau: disulfide-independent aggregation and non-enzymatic degradation in vitro and in vivo. Journal of Neurochemistry. 90: 1302-11. PMID 15341514 DOI: 10.1111/j.1471-4159.2004.02611.x  0.451
2004 Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y. Gem GTPase and tau: morphological changes induced by gem GTPase in cho cells are antagonized by tau. The Journal of Biological Chemistry. 279: 27272-7. PMID 15087445 DOI: 10.1074/Jbc.M401634200  0.451
2004 Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T. Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1013-5. PMID 15084524 DOI: 10.1096/fj.03-1040fje  0.468
2004 Morishima M, Qi Y, Ihara Y. P1-157 Presence of long Aβ in the lysate: an implication for the mechanism of gamma-secretase cleavage Neurobiology of Aging. 25: S140. DOI: 10.1016/S0197-4580(04)80470-6  0.324
2003 Wada S, Morishima-Kawashima M, Qi Y, Misono H, Shimada Y, Ohno-Iwashita Y, Ihara Y. Gamma-secretase activity is present in rafts but is not cholesterol-dependent. Biochemistry. 42: 13977-86. PMID 14636066 DOI: 10.1021/bi034904j  0.345
2003 Kanamori T, Nishimaki K, Asoh S, Ishibashi Y, Takata I, Kuwabara T, Taira K, Yamaguchi H, Sugihara S, Yamazaki T, Ihara Y, Nakano K, Matuda S, Ohta S. Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. The Embo Journal. 22: 2913-23. PMID 12805207 DOI: 10.1093/emboj/cdg299  0.31
2003 Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 24294-301. PMID 12707272 DOI: 10.1074/Jbc.M211161200  0.724
2003 Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, Ihara Y. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells. Biochemistry. 42: 1042-52. PMID 12549925 DOI: 10.1021/bi0267590  0.4
2002 Morishima-Kawashima M, Ihara Y. Alzheimer's disease: beta-Amyloid protein and tau. Journal of Neuroscience Research. 70: 392-401. PMID 12391602 DOI: 10.1002/jnr.10355  0.492
2001 Miyasaka T, Morishima-Kawashima M, Ravid R, Kamphorst W, Nagashima K, Ihara Y. Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation. Journal of Neuropathology and Experimental Neurology. 60: 872-84. PMID 11556544 DOI: 10.1093/Jnen/60.9.872  0.434
2001 Gu Y, Misonou H, Sato T, Dohmae N, Takio K, Ihara Y. Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch. The Journal of Biological Chemistry. 276: 35235-8. PMID 11483588 DOI: 10.1074/jbc.C100357200  0.721
2001 Yamaguchi H, Sugihara S, Ogawa A, Oshima N, Ihara Y. Alzheimer beta amyloid deposition enhanced by apoE epsilon4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects. Journal of Neuropathology and Experimental Neurology. 60: 731-9. PMID 11444802 DOI: 10.1093/Jnen/60.7.731  0.414
2001 Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y. Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain. The American Journal of Pathology. 158: 2209-18. PMID 11395399 DOI: 10.1016/S0002-9440(10)64693-7  0.411
2001 Ihara Y. PHF and PHF-like fibrils--cause or consequence? Neurobiology of Aging. 22: 123-6. PMID 11164285 DOI: 10.1016/S0197-4580(00)00200-1  0.324
2001 Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y. Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation. The American Journal of Pathology. 158: 373-9. PMID 11159174 DOI: 10.1016/S0002-9440(10)63979-X  0.409
2000 Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, Ihara Y. Effect of apolipoprotein E allele epsilon4 on the initial phase of amyloid beta-protein accumulation in the human brain. The American Journal of Pathology. 157: 2093-9. PMID 11106581 DOI: 10.1016/S0002-9440(10)64847-X  0.418
2000 Saito Y, Kawai M, Inoue K, Sasaki R, Arai H, Nanba E, Kuzuhara S, Ihara Y, Kanazawa I, Murayama S. Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. Journal of the Neurological Sciences. 177: 48-59. PMID 10967182 DOI: 10.1016/S0022-510X(00)00337-3  0.362
2000 Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y. Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. The Journal of Biological Chemistry. 275: 27901-8. PMID 10846187 DOI: 10.1074/Jbc.M004308200  0.385
2000 Misonou H, Morishima-Kawashima M, Ihara Y. Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry. 39: 6951-9. PMID 10841777 DOI: 10.1021/bi000169p  0.72
2000 Gu Y, Ihara Y. Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules. The Journal of Biological Chemistry. 275: 17917-20. PMID 10770920 DOI: 10.1074/jbc.C000179200  0.318
2000 Gu Y, Hamajima N, Ihara Y. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. Biochemistry. 39: 4267-75. PMID 10757975 DOI: 10.1021/bi992323h  0.395
2000 Ihara Y. The role of tau in Alzheimer's disease Neurobiology of Aging. 21: 210. DOI: 10.1016/S0197-4580(00)83271-6  0.41
2000 Saito Y, Gayer A, Hamano T, Sasaki R, Nanbe E, Nakamura K, Ihara Y, Suzuki K. Molecular pathological studies of neurofibrillary tangle-predominant form of dementia Neurobiology of Aging. 21: 264. DOI: 10.1016/S0197-4580(00)83143-7  0.358
1999 Funato H, Enya M, Yoshimura M, Morishima-Kawashima M, Ihara Y. Presence of sodium dodecyl sulfate-stable amyloid beta-protein dimers in the hippocampus CA1 not exhibiting neurofibrillary tangle formation. The American Journal of Pathology. 155: 23-8. PMID 10393832 DOI: 10.1016/S0002-9440(10)65094-8  0.44
1999 Matsumura N, Yamazaki T, Ihara Y. Stable expression in Chinese hamster ovary cells of mutated tau genes causing frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). The American Journal of Pathology. 154: 1649-56. PMID 10362789 DOI: 10.1016/S0002-9440(10)65420-X  0.419
1999 Watanabe A, Takio K, Ihara Y. Deamidation and isoaspartate formation in smeared tau in paired helical filaments. Unusual properties of the microtubule-binding domain of tau. The Journal of Biological Chemistry. 274: 7368-78. PMID 10066801 DOI: 10.1074/jbc.274.11.7368  0.387
1999 Enya M, Morishima-Kawashima M, Yoshimura M, Shinkai Y, Kusui K, Khan K, Games D, Schenk D, Sugihara S, Yamaguchi H, Ihara Y. Appearance of sodium dodecyl sulfate-stable amyloid beta-protein (Abeta) dimer in the cortex during aging. The American Journal of Pathology. 154: 271-9. PMID 9916941  0.3
1998 Oyama F, Murakami N, Ihara Y. Chloroquine myopathy suggests that tau is degraded in lysosomes: implication for the formation of paired helical filaments in Alzheimer's disease. Neuroscience Research. 31: 1-8. PMID 9704973 DOI: 10.1016/S0168-0102(98)00020-0  0.44
1998 Murakami N, Oyama F, Gu Y, McLennan IS, Nonaka I, Ihara Y. Accumulation of tau in autophagic vacuoles in chloroquine myopathy. Journal of Neuropathology and Experimental Neurology. 57: 664-73. PMID 9690670 DOI: 10.1097/00005072-199807000-00003  0.446
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, ... Ihara Y, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X  0.59
1998 Funato H, Yoshimura M, Kusui K, Tamaoka A, Ishikawa K, Ohkoshi N, Namekata K, Okeda R, Ihara Y. Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease. The American Journal of Pathology. 152: 1633-40. PMID 9626067  0.304
1998 Yamazaki T, Ihara Y. Effects of specific protease inhibitors on amyloid β-protein 42 secretion Neurobiology of Aging. 19: S77-S79. PMID 9562473 DOI: 10.1016/S0197-4580(98)00031-1  0.426
1998 Yanagisawa K, Ihara Y. GM1 ganglioside-bound amyloid β-protein in Alzheimer's disease brain Neurobiology of Aging. 19: S65-S67. PMID 9562471 DOI: 10.1016/S0197-4580(98)00032-3  0.453
1998 Davies P, Resnick J, Resnick B, Gilman S, Growdon JH, Khachaturian ZS, Radebaugh TS, Roses AD, Selkoe DJ, Trojanowski JQ, Blass JP, Gibson GE, Sheu KFR, Blennow K, Delacourte A, ... ... Ihara Y, et al. Consensus report of the working group on: 'Molecular and biochemical markers of Alzheimer's disease' Neurobiology of Aging. 19: 109-116. PMID 9558143 DOI: 10.1016/S0197-4580(98)00022-0  0.64
1998 Funato H, Yoshimura M, Yamazaki T, Saido TC, Ito Y, Yokofujita J, Okeda R, Ihara Y. Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain. The American Journal of Pathology. 152: 983-92. PMID 9546359  0.333
1998 Yoshida H, Watanabe A, Ihara Y. Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease. The Journal of Biological Chemistry. 273: 9761-8. PMID 9545313 DOI: 10.1074/jbc.273.16.9761  0.441
1998 Yamaguchi H, Sugihara S, Ogawa A, Saido TC, Ihara Y. Diffuse plaques associated with astroglial amyloid beta protein, possibly showing a disappearing stage of senile plaques. Acta Neuropathologica. 95: 217-22. PMID 9542585 DOI: 10.1007/s004010050790  0.378
1997 Yanagisawa K, McLaurin J, Michikawa M, Chakrabartty A, Ihara Y. Amyloid β-protein (Aβ) associated with lipid molecules: Immunoreactivity distinct from that of soluble Aβ Febs Letters. 420: 43-46. PMID 9450547 DOI: 10.1016/S0014-5793(97)01484-1  0.401
1997 Namekata K, Imagawa M, Terashi A, Ohta S, Oyama F, Ihara Y. Association of transferrin C2 allele with late-onset Alzheimer's disease Human Genetics. 101: 126-129. PMID 9402955 DOI: 10.1007/s004390050600  0.342
1997 Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T. Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. Neuroreport. 8: 2797-801. PMID 9295120 DOI: 10.1097/00001756-199708180-00029  0.525
1997 Hamano T, Yoshimura M, Yamazaki T, Shinkai Y, Yanagisawa K, Kuriyama M, Ihara Y. Amyloid β-protein (Aβ) accumulation in the leptomeninges during aging and in Alzheimer disease Journal of Neuropathology and Experimental Neurology. 56: 922-932. PMID 9258262 DOI: 10.1097/00005072-199708000-00010  0.411
1997 Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/Bi970209Y  0.437
1997 Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C. Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. The Journal of Biological Chemistry. 272: 16085-8. PMID 9195901 DOI: 10.1074/jbc.272.26.16085  0.396
1997 Yamazaki T, Ihara Y. Molecular pathology of Alzheimer's disease Neuropathology. 17: 263-269. DOI: 10.1111/J.1440-1789.1997.Tb00051.X  0.369
1996 Kanemaru K, Iwatsubo T, Ihara Y. Comparable amyloid beta-protein (A beta) 42(43) and A beta 40 deposition in the aged monkey brain. Neuroscience Letters. 214: 196-8. PMID 8878117 DOI: 10.1016/0304-3940(96)12893-7  0.531
1996 Hasegawa M, Jakes R, Crowther RA, Lee VM, Ihara Y, Goedert M. Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein. Febs Letters. 384: 25-30. PMID 8797796 DOI: 10.1016/0014-5793(96)00271-2  0.42
1996 Gu Y, Oyama F, Ihara Y. Tau is widely expressed in rat tissues. Journal of Neurochemistry. 67: 1235-44. PMID 8752131 DOI: 10.1046/j.1471-4159.1996.67031235.x  0.389
1996 Nomura Y, Yamanaka Y, Kitamura Y, Arima T, Ohnuki T, Oomura Y, Sasaki K, Nagashima K, Ihara Y. Senescence-accelerated mouse. Neurochemical studies on aging. Annals of the New York Academy of Sciences. 786: 410-8. PMID 8687038 DOI: 10.1111/J.1749-6632.1996.Tb39080.X  0.404
1996 Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Lewy bodies: purification from diffuse Lewy body disease brains. Annals of the New York Academy of Sciences. 786: 195-205. PMID 8687019 DOI: 10.1111/J.1749-6632.1996.Tb39062.X  0.45
1996 Yanagisawa K, Asami-Odaka A, Suzuki N, Ihara Y. Fractionation of amyloid beta-protein (A beta) in Alzheimer's disease and Down's syndrome brains. Presence of membrane-bound A beta. Annals of the New York Academy of Sciences. 786: 184-94. PMID 8687018 DOI: 10.1111/J.1749-6632.1996.Tb39061.X  0.408
1996 Mann DM, Iwatsubo T, Ihara Y, Cairns NJ, Lantos PL, Bogdanovic N, Lannfelt L, Winblad B, Maat-Schieman ML, Rossor MN. Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene. The American Journal of Pathology. 148: 1257-66. PMID 8644866  0.503
1996 Iwatsubo T, Yamaguchi H, Fujimuro M, Yokosawa H, Ihara Y, Trojanowski JQ, Lee VM. Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease. The American Journal of Pathology. 148: 1517-29. PMID 8623921  0.433
1996 Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubo T. Amyloid beta protein deposition in normal aging has the same characteristics as that in Alzheimer's disease. Predominance of A beta 42(43) and association of A beta 40 with cored plaques. The American Journal of Pathology. 148: 259-65. PMID 8546214  0.486
1996 Yanagisawa K, Odaka A, Suzuki N, Ihara Y. GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease. Nature Medicine. 1: 1062-6. PMID 7489364 DOI: 10.1038/Nm1095-1062  0.423
1996 Yanagisawa K, Asami-Odaka A, Suzuki N, Ihara Y. 793 GM1 ganglioside-bound amyloid ß-protein: A possible form of preamyloid Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80795-0  0.389
1996 Oyama F, Gu Y, Murakami N, Nonaka I, Ihara Y. 759 Nonneural tau : Transient upregulation and subsequent accumulation of big and small tau in chloroquine myopathy Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80761-5  0.422
1996 Hamano T, Shinkai Y, Yanagisawa K, Yoshimura M, Yamazaki T, Kuriyama M, Ihara Y. 688 Amyloid β-protein accumulates in the leptomeninges Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80690-7  0.324
1996 Shinkai Y, Yoshimura M, Ito Y, Shimada H, Asami-Odaka A, Suzuki N, Yanagisawa K, Ihara Y. 687 Differential patterns of amyloid β-protein deposition in cerebral cortex and leptomeninges Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80689-0  0.307
1996 Fukumoto H, Asami-Odaka A, Suzuki N, Shimada H, Ihara Y, Iwatsubos T. 530 Amyloid β protein (Aβ) deposition in normal aging has the same characteristics as that in Alzheimer's disease: Predominance of Aβ42(43) and association of Aβ40 with cored plaques and microglial cells Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80532-X  0.425
1996 Yamamoto H, Hasegawa M, Ono T, Ihara Y, Miyamoto E. 510 Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases in brain Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80512-4  0.426
1996 Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T. 507 Distribution of Phosphorylated Tau in Neonatal and Adult Rat Brains Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80509-4  0.487
1995 Yamamoto H, Hasegawa M, Ono T, Tashima K, Ihara Y, Miyamoto E. Dephosphorylation of fetal-tau and paired helical filaments-tau by protein phosphatases 1 and 2A and calcineurin. Journal of Biochemistry. 118: 1224-1231. PMID 8720139 DOI: 10.1093/Oxfordjournals.Jbchem.A125011  0.43
1995 Mann DM, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid beta protein (A beta) deposition; association with A beta 40-containing plaques. Acta Neuropathologica. 90: 472-7. PMID 8560980 DOI: 10.1007/Bf00294808  0.528
1995 Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S. Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron. 14: 457-66. PMID 7857653 DOI: 10.1016/0896-6273(95)90301-1  0.528
1995 Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Titani K, Ihara Y. Proline-Directed And Non-Proline-Directed Phosphorylation Of Phf-Tau Journal of Biological Chemistry. 270: 823-829. PMID 7822317 DOI: 10.1074/Jbc.270.2.823  0.341
1995 Murakami N, Ihara Y, Nonaka I. Chloroquine treated rat: a possible model for Alzheimer's disease. Muscle & Nerve. 18: 123-5. PMID 7799987 DOI: 10.1002/MUS.880180120  0.323
1995 Oyama F, Shimada H, Oyama R, Ihara Y. Apolipoprotein E genotype, Alzheimer's pathologies and related gene expression in the aged population. Molecular Brain Research. 29: 92-98. PMID 7770005 DOI: 10.1016/0169-328X(94)00233-5  0.423
1995 Murakami N, Ihara Y, Nonaka I. Muscle fiber degeneration in distal myopathy with rimmed vacuole formation. Acta Neuropathologica. 89: 29-34. PMID 7709728 DOI: 10.1007/BF00294256  0.427
1995 Iwatsubo T, Mann DM, Odaka A, Suzuki N, Ihara Y. Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome. Annals of Neurology. 37: 294-9. PMID 7695229 DOI: 10.1002/Ana.410370305  0.523
1995 Shinkai Y, Yoshimura M, Ito Y, Odaka A, Suzuki N, Yanagisawa K, Ihara Y. Amyloid β‐proteins 1—40 and 1—42(43) in the soluble fraction of extra‐ and intracranial blood vessels Annals of Neurology. 38: 421-428. PMID 7668828 DOI: 10.1002/Ana.410380312  0.403
1995 Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Yoshida H, Watanabe A, Titani K, Ihara Y. Hyperphosphorylation of tau in PHF. Neurobiology of Aging. 16: 365-71; discussion 3. PMID 7566346 DOI: 10.1016/0197-4580(95)00027-C  0.395
1995 Mann DM, Pickering-Brown SM, Siddons MA, Iwatsubo T, Ihara Y, Asami-Odaka A, Suzuki N. The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype. Neuroscience Letters. 196: 105-8. PMID 7501233 DOI: 10.1016/0304-3940(95)11860-Y  0.471
1995 Mann DMA, Iwatsubo T, Fukumoto H, Ihara Y, Odaka A, Suzuki N. Microglial cells and amyloid ? protein (A?) deposition: association with A?40-containing plaques Acta Neuropathologica. 90: 472-477. DOI: 10.1007/S004010050358  0.544
1994 Uéda K, Fukushima H, Masliah E, Xia Y, Iwai A, Yoshimoto M, Otero DA, Kondo J, Ihara Y, Saitoh T. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 11282-6. PMID 8248242 DOI: 10.1073/Pnas.90.23.11282  0.468
1994 Oyama F, Cairns NJ, Shimada H, Oyama R, Titani K, Ihara Y. Down's syndrome: up-regulation of beta-amyloid protein precursor and tau mRNAs and their defective coordination. Journal of Neurochemistry. 62: 1062-6. PMID 8113792 DOI: 10.1046/J.1471-4159.1994.62031062.X  0.454
1994 Suzuki N, Iwatsubo T, Odaka A, Ishibashi Y, Kitada C, Ihara Y. High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy. The American Journal of Pathology. 145: 452-60. PMID 8053502  0.459
1994 Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43). Neuron. 13: 45-53. PMID 8043280 DOI: 10.1016/0896-6273(94)90458-8  0.53
1994 Iwatsubo T, Hasegawa M, Ihara Y. Neuronal and glial tau-positive inclusions in diverse neurologic diseases share common phosphorylation characteristics. Acta Neuropathologica. 88: 129-36. PMID 7985493 DOI: 10.1007/Bf00294505  0.573
1994 Morishima M, Ihara Y. Posttranslational modifications of tau in paired helical filaments. Dementia (Basel, Switzerland). 5: 282-8. PMID 7951685 DOI: 10.1159/000106736  0.437
1994 Sawa A, Oyama F, Matsushita M, Ihara Y. Molecular diversity at the carboxyl terminus of human and rat tau. Brain Research. Molecular Brain Research. 27: 111-7. PMID 7877441 DOI: 10.1016/0169-328X(94)90191-0  0.339
1993 Oyama F, Shimada H, Oyama R, Titani K, Ihara Y. Beta-amyloid protein precursor and tau mRNA levels versus beta-amyloid plaque and neurofibrillary tangles in the aged human brain. Journal of Neurochemistry. 60: 1658-64. PMID 8473889 DOI: 10.1111/j.1471-4159.1993.tb13388.x  0.464
1993 Morishima-Kawashima M, Hasegawa M, Takio K, Suzuki M, Titani K, Ihara Y. Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments. Neuron. 10: 1151-60. PMID 8391280 DOI: 10.1016/0896-6273(93)90063-W  0.384
1993 Yoshida H, Ihara Y. Tau in paired helical filaments is functionally distinct from fetal tau: assembly incompetence of paired helical filament-tau. Journal of Neurochemistry. 61: 1183-6. PMID 8360683 DOI: 10.1111/j.1471-4159.1993.tb03642.x  0.4
1993 Hasegawa M, Watanabe A, Takio K, Suzuki M, Arai T, Titani K, Ihara Y. Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal-Type Phosphorylation of the τ in Paired Helical Filaments Journal of Neurochemistry. 60: 2068-2077. PMID 7684067 DOI: 10.1111/J.1471-4159.1993.Tb03491.X  0.368
1992 Kanemaru K, Takio K, Miura R, Titani K, Ihara Y. Fetal-type phosphorylation of the tau in paired helical filaments. Journal of Neurochemistry. 58: 1667-75. PMID 1560225 DOI: 10.1111/j.1471-4159.1992.tb10039.x  0.34
1992 Oyama F, Shimada H, Oyama R, Titani K, Ihara Y. A novel correlation between the levels of beta-amyloid protein precursor and tau transcripts in the aged human brain. Journal of Neurochemistry. 59: 1117-25. PMID 1494902 DOI: 10.1111/j.1471-4159.1992.tb08354.x  0.449
1992 Yanagisawa K, Ihara Y, Miyatake T. Secretory pathway of beta/A4 amyloid protein precursor in familial Alzheimer's disease with Val717 to Ile mutation. Neuroscience Letters. 144: 43-5. PMID 1436712 DOI: 10.1016/0304-3940(92)90711-F  0.383
1992 Watanabe N, Takio K, Hasegawa M, Arai T, Titani K, Ihara Y. Tau 2: a probe for a Ser conformation in the amino terminus of tau. Journal of Neurochemistry. 58: 960-6. PMID 1371153 DOI: 10.1111/j.1471-4159.1992.tb09349.x  0.418
1992 Iwatsubo T, Hasegawa M, Esaki Y, Ihara Y. Lack of ubiquitin immunoreactivities at both ends of neuropil threads. Possible bidirectional growth of neuropil threads. The American Journal of Pathology. 140: 277-82. PMID 1310831  0.495
1992 Tsuji S, Kobayashi H, Uchida Y, Ihara Y, Miyatake T. Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. The Embo Journal. 11: 4843-4850. DOI: 10.1002/J.1460-2075.1992.Tb05590.X  0.388
1991 Morishima-Kawashima M, Arai T, Ogawara M, Takio K, Titani K, Saitoh T, Kosik KS, Ihara Y. A possible fetal antigen of Mr 70,000 in neurofibrillary tangles. Brain Research. 554: 316-320. PMID 1933313 DOI: 10.1016/0006-8993(91)90208-D  0.383
1991 Oyama F, Shimada H, Oyama R, Titani K, Ihara Y. Differential Expression of β Amyloid Protein Precursor (APP) and tau mRNA in the Aged Human Brain: Individual Variability and Correlation between APP-751 and Four-Repeat tau Journal of Neuropathology and Experimental Neurology. 50: 560-578. PMID 1910077 DOI: 10.1097/00005072-199109000-00004  0.429
1991 Yamaguchi H, Nakazato Y, Kawarabayashi T, Ishiguro K, Ihara Y, Morimatsu M, Hirai S. Extracellular neurofibrillary tangles associated with degenerating neurites and neuropil threads in Alzheimer-type dementia. Acta Neuropathologica. 81: 603-609. PMID 1882636 DOI: 10.1007/Bf00296369  0.384
1991 Uchida Y, Takio K, Titani K, Ihara Y, Tomonaga M. The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron. 7: 337-47. PMID 1873033 DOI: 10.1016/0896-6273(91)90272-2  0.373
1991 Tokuda T, Ikeda S, Yanagisawa N, Ihara Y, Glenner GG. Re-examination of ex-boxers' brains using immunohistochemistry with antibodies to amyloid beta-protein and tau protein. Acta Neuropathologica. 82: 280-285. PMID 1759560 DOI: 10.1007/Bf00308813  0.478
1991 Mori H, Ihara Y. Neurofibrillary Tangles, Dystrophic IMeurites (Curly Fibers), and Abnormal Phosphorylation of Tau Brain Pathology. 1: 273-277. PMID 1669717 DOI: 10.1111/J.1750-3639.1991.Tb00670.X  0.327
1991 Ihara Y, Hasegawa M, Morishima M, Takio K. Paired helical filaments (PHF) and abnormally phosphorylated tau Neuroscience Research Supplements. 16: VIII. DOI: 10.1016/0921-8696(91)90616-U  0.366
1990 Kondo J, Honda T, Mori H, Hamada Y, Miura R, Ogawara M, Ihara Y. The carboxyl third of tau is tightly bound to paired helical filaments. Neuron. 1: 827-34. PMID 2483105 DOI: 10.1016/0896-6273(88)90130-4  0.413
1990 Hasegawa M, Arai T, Ihara Y. Immunochemical evidence that fragments of phosphorylated MAP5 (MAP1B) are bound to neurofibrillary tangles in Alzheimer's disease. Neuron. 4: 909-18. PMID 2361014 DOI: 10.1016/0896-6273(90)90144-5  0.349
1990 Murayama S, Mori H, Ihara Y, Tomonaga M. Immunocytochemical and ultrastructural studies of Pick's disease. Annals of Neurology. 27: 394-405. PMID 2162145 DOI: 10.1002/Ana.410270407  0.323
1990 Murayama S, Mori H, Ihara Y, Bouldin TW, Suzuki K, Tomonaga M. Immunocytochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosis. Annals of Neurology. 27: 137-48. PMID 2156479 DOI: 10.1002/Ana.410270208  0.304
1990 Yamaguchi H, Ishiguro K, Shoji M, Yamazaki T, Nakazato Y, Ihara Y, Hirai S. Amyloid β/A4 protein precursor is bound to neurofibrillary tangles in Alzheimer-type dementia Brain Research. 537: 318-322. PMID 1982242 DOI: 10.1016/0006-8993(90)90377-N  0.437
1990 Ihara Y, Kondo J, Miura R, Nakagawa Y, Mori H, Honda T. Characterization of antisera to paired helical filaments and tau. Implication for the extent of tau tightly bound to paired helical filaments. Gerontology. 36: 15-24. PMID 1696559 DOI: 10.1159/000213229  0.399
1989 Ihara Y. What mediates between beta-amyloid and paired helical filaments? Neurobiology of Aging. 10: 573-4; discussion 58. PMID 2530464 DOI: 10.1016/0197-4580(89)90132-2  0.451
1989 Kanai Y, Takemura R, Oshima T, Mori H, Ihara Y, Yanagisawa M, Masaki T, Hirokawa N. Expression of multiple tau isoforms and microtubule bundle formation in fibroblasts transfected with a single tau cDNA. The Journal of Cell Biology. 109: 1173-84. PMID 2504728 DOI: 10.1083/Jcb.109.3.1173  0.419
1989 Takio K, Hasegawa M, Titani K, Ihara Y. Identification of beta protein precursor in newborn rat brain. Biochemical and Biophysical Research Communications. 160: 1296-301. PMID 2499330 DOI: 10.1016/S0006-291X(89)80144-5  0.378
1989 Mori H, Hamada Y, Kawaguchi M, Honda T, Kondo J, Ihara Y. A distinct form of tau is selectively incorporated into Alzheimer's paired helical filaments Biochemical and Biophysical Research Communications. 159: 1221-1226. PMID 2495000 DOI: 10.1016/0006-291X(89)92240-7  0.437
1989 Ivy GO, Kitani K, Ihara Y. Anomalous accumulation of tau and ubiquitin immunoreactivities in rat brain caused by protease inhibition and by normal aging: a clue to PHF pathogenesis? Brain Research. 498: 360-5. PMID 2477115 DOI: 10.1016/0006-8993(89)91117-7  0.413
1988 Kuzuhara S, Mori H, Izumiyama N, Yoshimura M, Ihara Y. Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study. Acta Neuropathologica. 75: 345-53. PMID 3364159 DOI: 10.1007/Bf00687787  0.382
1988 Uchida Y, Ihara Y, Tomonaga M. Alzheimer's disease brain extract stimulates the survival of cerebral cortical neurons from neonatal rats Biochemical and Biophysical Research Communications. 150: 1263-1267. PMID 3342070 DOI: 10.1016/0006-291X(88)90765-6  0.356
1988 Ihara Y. Massive somatodendritic sprouting of cortical neurons in Alzheimer's disease. Brain Research. 459: 138-44. PMID 3139259 DOI: 10.1016/0006-8993(88)90293-4  0.394
1988 Ishiguro K, Ihara Y, Uchida T, Imahori K. A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau. Journal of Biochemistry. 104: 319-321. PMID 2467901 DOI: 10.1093/Oxfordjournals.Jbchem.A122465  0.405
1987 Mori H, Kondo J, Ihara Y. Ubiquitin is a component of paired helical filaments in Alzheimer's disease Science. 235: 1641-1644. PMID 3029875 DOI: 10.1126/Science.3029875  0.401
1986 Ihara Y, Nukina N, Miura R, Ogawara M. Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease. Journal of Biochemistry. 99: 1807-10. PMID 2427509 DOI: 10.1097/00002093-198701030-00016  0.414
1986 Nukina N, Ihara Y. One of the antigenic determinants of paired helical filaments is related to tau protein. Journal of Biochemistry. 99: 1541-4. PMID 2423512 DOI: 10.1093/Oxfordjournals.Jbchem.A135625  0.464
1986 Nukina N, Kosik K, Selkoe D, Ihara Y. TAU PROTEIN IS INTEGRATED INTO PAIRED HELICAL FILAMENTS (PHF) IN ALZHEIMERʼS DISEASE (AD) Journal of Neuropathology and Experimental Neurology. 45: 338. DOI: 10.1097/00005072-198605000-00074  0.563
1985 Nukina N, Ihara Y. Proteolytic fragments of Alzheimer's paired helical filaments. Journal of Biochemistry. 98: 1715-8. PMID 2419316 DOI: 10.1093/Oxfordjournals.Jbchem.A135443  0.311
1983 Ihara Y, Abraham C, Selkoe DJ. Antibodies to paired helical filaments in Alzheimer's disease do not recognize normal brain proteins. Nature. 304: 727-30. PMID 6350889 DOI: 10.1038/304727A0  0.535
1983 Selkoe D, Abraham C, Ihara Y, Pope A. 105 ANTIBODIES TO THE FAIL TO REACT WITH NEUROFILAMENTS AND OTHER NORMAL PROTEINS Journal of Neuropathology and Experimental Neurology. 42: 340. DOI: 10.1097/00005072-198305000-00112  0.457
1982 Selkoe DJ, Abraham C, Ihara Y. Brain transglutaminase: in vitro crosslinking of human neurofilament proteins into insoluble polymers. Proceedings of the National Academy of Sciences of the United States of America. 79: 6070-4. PMID 6136967 DOI: 10.1073/Pnas.79.19.6070  0.511
1982 Selkoe DJ, Ihara Y, Salazar FJ. Alzheimer's disease: insolubility of partially purified paired helical filaments in sodium dodecyl sulfate and urea. Science (New York, N.Y.). 215: 1243-5. PMID 6120571 DOI: 10.1126/Science.6120571  0.525
1982 Selkoe DJ, Abraham C, Ihara Y. CROSSLINKING OF ALZHEIMER PAIRED HELICAL FILAMENTS Journal of Neuropathology and Experimental Neurology. 41: 354. DOI: 10.1097/00005072-198205000-00048  0.543
1979 Ihara Y, Fujii T, Arai T, Tanaka R, Kaziro Y. The presence of an adenosine-5'-triphosphatase dependent on 6S tubulin and calcium ions in rat brain microtubules Journal of Biochemistry. 86: 587-590. PMID 158016 DOI: 10.1093/Oxfordjournals.Jbchem.A132560  0.328
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