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Ranjit S. Bindra, Ph.D. - Publications

Affiliations: 
2005 Yale University, New Haven, CT 
Area:
Molecular Biology
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Year Citation  Score
2022 Singh C, Bindra RS, Glazer PM, Vasquez JC, Pashankar F. Metastatic and multiply relapsed SDH-deficient GIST and paraganglioma displays clinical response to combined poly ADP-ribose polymerase inhibition and temozolomide. Pediatric Blood & Cancer. e30020. PMID 36151992 DOI: 10.1002/pbc.30020  0.466
2022 Ueno D, Vasquez JC, Sule A, Liang J, van Doorn J, Sundaram R, Friedman S, Caliliw R, Ohtake S, Bao X, Li J, Ye H, Boyd K, Huang RR, Dodson J, ... ... Bindra RS, et al. Targeting Krebs-cycle-deficient renal cell carcinoma with Poly ADP-ribose polymerase inhibitors and low-dose alkylating chemotherapy. Oncotarget. 13: 1054-1067. PMID 36128328 DOI: 10.18632/oncotarget.28273  0.302
2022 Lin K, Gueble SE, Sundaram RK, Huseman ED, Bindra RS, Herzon SB. Mechanism-based design of agents that selectively target drug-resistant glioma. Science (New York, N.Y.). 377: 502-511. PMID 35901163 DOI: 10.1126/science.abn7570  0.315
2021 Eder JP, Doroshow DB, Do KT, Keedy VL, Sklar JS, Glazer P, Bindra R, Shapiro GI. Clinical Efficacy of Olaparib in Mutant Mesenchymal Sarcomas. Jco Precision Oncology. 5: 466-472. PMID 34994649 DOI: 10.1200/PO.20.00247  0.521
2021 Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, ... ... Bindra RS, et al. Correction to 'Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity'. Nar Cancer. 3: zcab047. PMID 34888524 DOI: 10.1093/narcan/zcab047  0.47
2021 Gueble SE, Bindra RS. Oncometabolites as Regulators of DNA Damage Response and Repair. Seminars in Radiation Oncology. 32: 82-94. PMID 34861999 DOI: 10.1016/j.semradonc.2021.09.004  0.348
2021 Gayle S, Aiello R, Leelatian N, Beckta JM, Bechtold J, Bourassa P, Csengery J, Maguire RJ, Marshall D, Sundaram RK, Van Doorn J, Jones K, Moore H, Lopresti-Morrow L, Paradis T, ... ... Bindra RS, et al. Tumor-selective, antigen-independent delivery of a pH sensitive peptide-topoisomerase inhibitor conjugate suppresses tumor growth without systemic toxicity. Nar Cancer. 3: zcab021. PMID 34316708 DOI: 10.1093/narcan/zcab021  0.536
2021 Garbarino J, Eckroate J, Sundaram RK, Jensen RB, Bindra RS. Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity. Translational Oncology. 14: 101147. PMID 34118569 DOI: 10.1016/j.tranon.2021.101147  0.333
2021 Sule A, Van Doorn J, Sundaram RK, Ganesa S, Vasquez JC, Bindra RS. Targeting IDH1/2 mutant cancers with combinations of ATR and PARP inhibitors. Nar Cancer. 3: zcab018. PMID 34027408 DOI: 10.1093/narcan/zcab018  0.35
2021 Paradkar S, Herrington J, Hendricson A, Hewawasam P, Plummer M, Hoyer D, Sundaram RK, Surovtseva YV, Bindra RS. Creation of a new class of radiosensitizers for glioblastoma based on the mibefradil pharmacophore. Oncotarget. 12: 891-906. PMID 33953843 DOI: 10.18632/oncotarget.27933  0.329
2020 Chen Y, Jiang T, Zhang H, Gou X, Han C, Wang J, Chen AT, Ma J, Liu J, Chen Z, Jing X, Lei H, Wang Z, Bao Y, Baqri M, ... ... Bindra RS, et al. LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy. Nature Cell Biology. 22: 1276-1285. PMID 33005030 DOI: 10.1038/s41556-020-00586-6  0.338
2020 Hong CS, Vasquez JC, Kundishora AJ, Elsamadicy AA, Beckta JM, Sule A, Marks AM, Leelatian N, Huttner A, Bindra RS, DiLuna ML, Kahle KT, Erson-Omay EZ. Persistent mutation despite multimodal therapy in recurrent pediatric glioblastoma. Npj Genomic Medicine. 5: 23. PMID 32528726 DOI: 10.1038/S41525-020-0130-7  0.371
2020 Sulkowski PL, Oeck S, Dow J, Economos NG, Mirfakhraie L, Liu Y, Noronha K, Bao X, Li J, Shuch BM, King MC, Bindra RS, Glazer PM. Oncometabolites suppress DNA repair by disrupting local chromatin signalling. Nature. PMID 32494005 DOI: 10.1038/S41586-020-2363-0  0.626
2020 Wen PY, Weller M, Lee EQ, Alexander BA, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, et al. Glioblastoma in Adults: A Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) Consensus Review on Current Management and Future Directions. Neuro-Oncology. PMID 32328653 DOI: 10.1093/Neuonc/Noaa106  0.341
2020 Gayle S, Aiello R, Bechtold J, Bourassa P, Csengery J, Deshpande K, Jones K, Lopresti-Morrow L, Maguire R, Marshall D, Moore H, Paradis T, Tylaska L, Zhang Q, Volkmann R, ... Bindra RS, et al. Abstract 6242: Development of alphalex™-toxin low pH targeting conjugates for the treatment of solid tumors Cancer Research. 80: 6242-6242. DOI: 10.1158/1538-7445.Am2020-6242  0.548
2020 Sule AD, Sundaram R, Bindra R. Abstract 1059: Targeting IDH1/2 mutant cancers with unique combinations of DNA repair inhibitors Tumor Biology. DOI: 10.1158/1538-7445.Am2020-1059  0.416
2019 Beckta JM, Bindra RS, Chalmers AJ. Targeting DNA repair in gliomas. Current Opinion in Neurology. PMID 31592790 DOI: 10.1097/Wco.0000000000000760  0.346
2019 Fons NR, Sundaram RK, Breuer GA, Peng S, McLean RL, Kalathil AN, Schmidt MS, Carvalho DM, Mackay A, Jones C, Carcaboso ÁM, Nazarian J, Berens ME, Brenner C, Bindra RS. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nature Communications. 10: 3790. PMID 31439867 DOI: 10.1038/S41467-019-11732-6  0.419
2019 Gallitto M, Lazarev S, Wasserman I, Stafford JM, Wolden SL, Terezakis SA, Bindra RS, Bakst RL. Role of Radiation Therapy in the Management of Diffuse Intrinsic Pontine Glioma: A Systematic Review. Advances in Radiation Oncology. 4: 520-531. PMID 31360809 DOI: 10.1016/J.Adro.2019.03.009  0.309
2019 Jackson CB, Noorbakhsh SI, Sundaram RK, Kalathil AN, Ganesa S, Jia L, Breslin H, Burgenske DM, Gilad O, Sarkaria JN, Bindra RS. Temozolomide sensitizes MGMT-deficient tumor cells to ATR inhibitors. Cancer Research. PMID 31273061 DOI: 10.1158/0008-5472.Can-18-3394  0.466
2019 Bindra R, Sundaram RK, Aiello RJ, Marshall D, Bourassa P, Csengery J, Zhang Q, Robinson B, lopresti-Morrow L, Bechtold J, Tylaska L, Paradis T, Paralkar V, Hellsund P, Glazer P. Unlocking PARP inhibitor efficacy for HRD-negative cancers using the alphalex tumor targeting platform inhibitor efficacy for HRD-negative cancers using the alphalex tumor targeting platform. Journal of Clinical Oncology. 37: e14664-e14664. DOI: 10.1200/Jco.2019.37.15_Suppl.E14664  0.59
2019 Gbyli R, Song Y, Liu W, Gao Y, Chandhok NS, Fu X, Wang X, Patel A, Sundaram R, Tebaldi T, Biancon G, Ardasheva A, Qin A, Sadykov M, Mamillapalli P, ... ... Bindra R, et al. PARP Inhibitors Are Effective in IDH1/2 Mutant MDS and AML Resistant to Targeted IDH Inhibitors Blood. 134: 4222-4222. DOI: 10.1182/Blood-2019-130814  0.394
2019 Chandhok NS, Wei W, Bindra R, Halene S, Shyr Y, Li J, Berens M, Karlovich C, Ivy SP, Prebet T. The PRIME Trial: PARP Inhibition in IDH Mutant Effectiveness Trial. a Phase II Study of Olaparib in Isocitrate Dehydrogenase (IDH) Mutant Relapsed/Refractory Acute Myeloid Leukemia and Myelodysplastic Syndrome Blood. 134: 3909-3909. DOI: 10.1182/Blood-2019-129168  0.409
2019 Sulkowski PS, Oeck S, Li J, Shuch B, King MC, Bindra RS, Glazer PM. Abstract SY21-02: Oncometabolites suppress homologous recombination DNA repair by inhibition of chromatin remodeling at the DNA double-strand break Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Sy21-02  0.635
2019 Paralkar V, Aiello RJ, Marshall D, Csengery J, Bourassa P, Zhang Q, Robinson BS, Lopresti-Morrow L, Bechtold J, Tylaska L, Paradis T, Slaybaugh G, Visca H, Moshnikova A, Weerakkody D, ... ... Bindra R, et al. Abstract 2981: Targeting solid tumor acidic microenvironment with an alphalex PARP inhibitor Cancer Research. 79: 2981-2981. DOI: 10.1158/1538-7445.Am2019-2981  0.581
2019 Sule A, Bindra R. RDNA-06. TARGETING IDH1/2-MUTANT GLIOMAS WITH UNIQUE COMBINATIONS OF DNA REPAIR INHIBITORS Neuro-Oncology. 21: vi208-vi208. DOI: 10.1093/Neuonc/Noz175.866  0.457
2019 Jackson C, Kalathil A, Bindra R. EXTH-55. TEMOZOLOMIDE-RESISTANT GLIOMA CELLS ARE SENSITIVE TO CHLOROETHYLATING NITROSOUREA COMPOUNDS IN COMBINATION WITH ATR INHIBITORS Neuro-Oncology. 21: vi94-vi94. DOI: 10.1093/Neuonc/Noz175.386  0.338
2019 Jackson C, Noorbakhsh S, Kalathil A, Sundaram R, Bindra R. MGMT-Deficiency Is a Biomarker to Guide Treatment of Solid Tumors with Temozolomide and ATR Inhibitors International Journal of Radiation Oncology*Biology*Physics. 105: E638-E639. DOI: 10.1016/J.Ijrobp.2019.06.1097  0.329
2018 Neel BG, Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer PM, Bindra RS, Moran MF, Linehan WM. Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma. Cancer Research. PMID 30297534 DOI: 10.1158/0008-5472.Can-18-0901  0.533
2018 Sulkowski PL, Sundaram RK, Oeck S, Corso CD, Liu Y, Noorbakhsh S, Niger M, Boeke M, Ueno D, Kalathil AN, Bao X, Li J, Shuch B, Bindra RS, Glazer PM. Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair. Nature Genetics. PMID 30013182 DOI: 10.1038/S41588-018-0170-4  0.623
2018 Marks AM, Bindra RS, DiLuna ML, Huttner A, Jairam V, Kahle KT, Kieran MW. Response to the BRAF/MEK inhibitors dabrafenib/trametinib in an adolescent with a BRAF V600E mutated anaplastic ganglioglioma intolerant to vemurafenib. Pediatric Blood & Cancer. PMID 29380516 DOI: 10.1002/Pbc.26969  0.34
2018 Cecchini M, Walther Z, Sklar JL, Bindra RS, Petrylak DP, Eder JP, Goldberg SB. Yale Cancer Center Precision Medicine Tumor Board: two patients, one targeted therapy, different outcomes. The Lancet. Oncology. 19: 23-24. PMID 29304353 DOI: 10.1016/S1470-2045(17)30916-6  0.319
2018 Cecchini M, Walther Z, Sklar JL, Bindra RS, Petrylak DP, Eder JP, Goldberg SB. Introduction to the Yale Precision Medicine Tumor Board. The Lancet. Oncology. 19: 19-20. PMID 29304351 DOI: 10.1016/S1470-2045(17)30919-1  0.305
2018 Lester-Coll NH, Supko JG, Kluytenaar J, Pavlik KF, Yu JB, Moliterno J, Piepmeier J, Becker K, Baehring JM, Huttner A, Vortmeyer A, Contessa JN, Ramani R, Lampert R, Yao X, ... Bindra R, et al. Mibefradil dihydrochoride with hypofractionated radiation for recurrent glioblastoma: A phase I dose expansion trial. Journal of Clinical Oncology. 36: e14046-e14046. DOI: 10.1200/Jco.2018.36.15_Suppl.E14046  0.359
2018 Eder JP, Shapiro GI, Cleary JM, Keedy VL, Bindra R, Shuch B, Sklar J, Do K, Juergensmeier J. Abstract CT159: Olaparib combinations (OLAPCO)for homology-directed DNA repairdefects (HDR) Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Ct159  0.415
2018 Jackson C, Noorbakhsh S, Sundaram R, Kalathil A, Bindra R. RDNA-05. SYNTHETIC SENSITIZATION OF MGMT-DEFICIENT TUMOR CELLS TO TEMOZOLOMIDE USING ATR INHIBITORS Neuro-Oncology. 20: vi222-vi222. DOI: 10.1093/Neuonc/Noy148.921  0.361
2018 Yu D, Daddacha W, Koyen A, Bastien A, Head P, Dhere V, Nabeta G, Connolly E, Werner E, Madden M, Daly M, Minten E, Whelan D, Zhang H, Anand R, ... ... Bindra R, et al. OC-0377: Targeting a Novel Function for SAMHD1 in DNA Repair for Radiation Therapy and PARP Inhibition Radiotherapy and Oncology. 127: S192-S193. DOI: 10.1016/S0167-8140(18)30687-X  0.381
2017 Ray S, Breuer G, DeVeaux M, Zelterman D, Bindra R, Sweasy JB. DNA polymerase beta participates in DNA End-joining. Nucleic Acids Research. PMID 29161447 DOI: 10.1093/Nar/Gkx1147  0.38
2017 Daddacha W, Koyen AE, Bastien AJ, Head PE, Dhere VR, Nabeta GN, Connolly EC, Werner E, Madden MZ, Daly MB, Minten EV, Whelan DR, Schlafstein AJ, Zhang H, Anand R, ... ... Bindra RS, et al. SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell Reports. 20: 1921-1935. PMID 28834754 DOI: 10.1016/J.Celrep.2017.08.008  0.408
2017 Bindra RS, Chalmers AJ, Evans S, Dewhirst M. GBM radiosensitizers: dead in the water…or just the beginning? Journal of Neuro-Oncology. PMID 28762004 DOI: 10.1007/S11060-017-2427-7  0.385
2017 Mutter RW, Riaz N, Ng CK, Delsite R, Piscuoglio S, Edelweiss M, Martelotto LG, Sakr RA, King TA, Giri DD, Drobnjak M, Brogi E, Bindra R, Bernheim G, Lim RS, et al. Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer. The Journal of Pathology. PMID 28299801 DOI: 10.1002/Path.4890  0.424
2017 Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, ... ... Bindra RS, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Science Translational Medicine. 9. PMID 28148839 DOI: 10.1126/Scitranslmed.Aal2463  0.618
2017 Bindra R, Sulkowski PL, Corso CD, Glazer P, Shuch BM. Induction of a BRCAness state by oncometabolites and exploitation by PARP inhibitors. Journal of Clinical Oncology. 35: 11586-11586. DOI: 10.1200/Jco.2017.35.15_Suppl.11586  0.618
2017 Hollick JJ, Abriola L, Bono F, Hegan D, Klingbeil P, Liu Y, Sundaram R, Surovtseva YV, Whittaker M, Bindra RS, Glazer PM. Abstract B25: “TargetDBR”—A DNA repair drug and target discovery collaboration: Exploiting synthetic lethal, high content, and functional cellular reporter assays to accelerate DNA repair targeted drug discovery Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-B25  0.629
2017 Sulkowski P, Corso C, Robinson N, Scanlon S, Purshouse K, Bai H, Liu Y, Sundaram R, Hegan D, Fons N, Breuer G, Song Y, Mishra K, Feyter HD, Graaf Rd, ... ... Bindra RS, et al. Abstract LB-290: Oncometabolites induce a BRCAness state that can be exploited by PARP inhibitors Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-290  0.634
2017 Ray S, DeVeaux M, Breuer G, Bindra R, Zelterman D, Sweasy J. Abstract 2492: DNA polymerase beta participates in DNA end-joining Cancer Research. 77: 2492-2492. DOI: 10.1158/1538-7445.Am2017-2492  0.388
2017 Corso C, Bindra R, Glazer P, Sulkowski P, Robinson N, Scanlon S, Purshouse K, Bai H, Liu Y, Sundaram R, Hegan D, Fons N, Breuer G, Song Y, Mishra-Gorur K, et al. Production of 2-Hydroxyglutarate by IDH Mutant Malignancies Induces a BRCAness State That Can be Exploited By PARP Inhibitors and Radiation International Journal of Radiation Oncology*Biology*Physics. 99: E68. DOI: 10.1016/J.Ijrobp.2017.06.754  0.525
2016 Gao S, Surovtseva Y, Bindra RS. RNF8 Regulates Nonhomologous End Joining and DNA-PK Recruitment to DNA Double-Strand Break Sites. International Journal of Radiation Oncology, Biology, Physics. 96: S55. PMID 27675958 DOI: 10.1016/J.Ijrobp.2016.06.143  0.365
2016 Janssen A, Breuer GA, Brinkman EK, van der Meulen AI, Borden SV, van Steensel B, Bindra RS, LaRocque JR, Karpen GH. A single double-strand break system reveals repair dynamics and mechanisms in heterochromatin and euchromatin. Genes & Development. 30: 1645-57. PMID 27474442 DOI: 10.1101/Gad.283028.116  0.372
2016 Surovtseva YV, Jairam V, Salem AF, Sundaram RK, Bindra RS, Herzon SB. Characterization of cardiac glycoside natural products as potent inhibitors of DNA double-strand break repair by a whole cell double immunofluorescence assay. Journal of the American Chemical Society. PMID 26927829 DOI: 10.1021/Jacs.6B00162  0.402
2016 Bindra RS, Wolden SL. Advances in Radiation Therapy in Pediatric Neuro-oncology. Journal of Child Neurology. 31: 506-16. PMID 26271789 DOI: 10.1177/0883073815597758  0.333
2016 Robinson ND, Purshouse KR, Fons NR, Breuer GA, Pusch S, Deimling Av, Sundaram RK, Bindra RS. Abstract 4277: Development and validation of a novel IDH1-mutant astrocyte cell line as a model for high-grade gliomas Cancer Research. 76: 4277-4277. DOI: 10.1158/1538-7445.Am2016-4277  0.435
2016 Fons NR, Surovtseva Y, Breuer GA, Sundaram RK, Bindra RS. Abstract 2466: Development of a novel gene targeting and clone screening platform to engineer common pediatric glioma mutations into model cell lines Cancer Research. 76: 2466-2466. DOI: 10.1158/1538-7445.Am2016-2466  0.366
2016 Surovtseva Y, Jairam V, Sundaram R, Bindra R, Herzon S. Abstract 2174: A high-throughput, high-content assay for the discovery of new inhibitors of DNA double-strand break repair Cancer Research. 76: 2174-2174. DOI: 10.1158/1538-7445.Am2016-2174  0.413
2015 Soong CP, Breuer GA, Hannon RA, Kim SD, Salem AF, Wang G, Yu R, Carriero NJ, Bjornson R, Sundaram RK, Bindra RS. Development of a novel method to create double-strand break repair fingerprints using next-generation sequencing. Dna Repair. 26: 44-53. PMID 25547252 DOI: 10.1016/J.Ijrobp.2013.06.057  0.409
2015 Goglia AG, Delsite R, Luz AN, Shahbazian D, Salem AF, Sundaram RK, Chiaravalli J, Hendrikx PJ, Wilshire JA, Jasin M, Kluger HM, Glickman JF, Powell SN, Bindra RS. Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors. Molecular Cancer Therapeutics. 14: 326-42. PMID 25512618 DOI: 10.1158/1535-7163.Mct-14-0765  0.462
2015 Lester-Coll NH, Kluytenaar J, Pavlik KF, Yu JB, Contessa JN, Moliterno J, Piepmeier JM, Becker KP, Baehring JM, Huttner AJ, Vortmeyer AO, Ramani R, Lampert RJ, Yao X, Bindra RS. ATNT-15MIBEFRADIL DIHYDROCHORIDE WITH HYPOFRACTIONATED RADIATION FOR RECURRENT GLIOBLASTOMA: PRELIMINARY RESULTS OF A PHASE I DOSE EXPANSION TRIAL Neuro-Oncology. 17: v13.3-v13. DOI: 10.1093/Neuonc/Nov205.15  0.311
2015 Fons N, Sundaram R, Bindra R. PM-11 * DEVELOPMENT OF A NOVEL GENE TARGETING AND CLONE SCREENING PLATFORM TO ENGINEER COMMON PEDIATRIC GLIOMA MUTATIONS INTO MODEL CELL LINES Neuro-Oncology. 17: iii33-iii33. DOI: 10.1093/Neuonc/Nov061.133  0.366
2015 Aneja S, Contessa J, Husain Z, Glazer P, Hansen J, Bindra R, Yu J. mRNA Expression of TP53 Attenuates Survival of HPV+ Locally Advanced Head and Neck Cancer International Journal of Radiation Oncology*Biology*Physics. 93: E350-E351. DOI: 10.1016/J.Ijrobp.2015.07.1440  0.495
2015 Jairam V, Sundaram R, Breuer G, Surovtseva Y, Bindra R. Identification and Characterization of Novel DNA Repair Inhibitors as Potential Tumor Cell Radiosensitizers International Journal of Radiation Oncology*Biology*Physics. 93: S48. DOI: 10.1016/J.Ijrobp.2015.07.116  0.447
2014 Salem A, Surovtseva Y, Sundaram R, Bindra R. High-Throughput RNAi Screening Platform Identifies Novel Regulators of DNA Double-Strand Break Repair Pathways International Journal of Radiation Oncology*Biology*Physics. 90: S34-S35. DOI: 10.1016/J.Ijrobp.2014.05.146  0.382
2013 Shahbazian D, Bindra RS, Kluger HM, Glazer PM. Radiation sensitivity and sensitization in melanoma. Pigment Cell & Melanoma Research. 26: 928-30. PMID 23870422 DOI: 10.1111/Pcmr.12147  0.525
2013 Bindra RS, Goglia AG, Jasin M, Powell SN. Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells. Nucleic Acids Research. 41: e115. PMID 23585275 DOI: 10.1093/Nar/Gkt255  0.387
2013 Salem A, Sundaram R, Surovtseva Y, Bindra R. High-Content, High-Throughput Screening for Novel Double-Strand Break Repair Inhibitors International Journal of Radiation Oncology*Biology*Physics. 87: S654. DOI: 10.1016/J.Ijrobp.2013.06.1732  0.314
2011 Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chemistry & Biology. 18: 1189-98. PMID 21944757 DOI: 10.1016/J.Chembiol.2011.07.010  0.72
2011 Powell S, Mutter R, Delsite R, Bindra R, King T, Giri D, Park J. PD10-02: Sporadic Breast Cancers Show Defects in the BRCA1-BRCA2 Pathway of Homologous Recombination in All Biomarker-Defined Sub-Types of Breast Cancer. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-Pd10-02  0.411
2010 Hegan DC, Lu Y, Stachelek GC, Crosby ME, Bindra RS, Glazer PM. Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. Proceedings of the National Academy of Sciences of the United States of America. 107: 2201-6. PMID 20133863 DOI: 10.1073/Pnas.0904783107  0.621
2010 Hegan DC, Lu Y, Stachelek GC, Crosby ME, Bindra RS, Glazer PM. Abstract 1969: Inhibition of poly(ADP-ribose) polymerase downregulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130 Cancer Research. 70: 1969-1969. DOI: 10.1158/1538-7445.Am10-1969  0.611
2010 Bindra R, Jasin M, Powell S. Development of a Novel Double-strand Break Repair Assay for High-throughput Small Molecule Screening in Glioma Cell Lines International Journal of Radiation Oncology*Biology*Physics. 78: S88. DOI: 10.1016/J.Ijrobp.2010.07.235  0.312
2009 Glazer PM, Bindra RS. Introduction: the evolving picture of the hypoxic tumour microenvironment. Current Molecular Medicine. 9: 399-400. PMID 19519396 DOI: 10.2174/156652409788167069  0.486
2009 Powell SN, Bindra RS. Targeting the DNA damage response for cancer therapy. Dna Repair. 8: 1153-65. PMID 19501553 DOI: 10.1016/J.Dnarep.2009.04.011  0.451
2008 Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG. Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Research. 68: 605-14. PMID 18199558 DOI: 10.1158/0008-5472.Can-07-5472  0.612
2007 Bindra RS, Crosby ME, Glazer PM. Regulation of DNA repair in hypoxic cancer cells Cancer and Metastasis Reviews. 26: 249-260. PMID 17415527 DOI: 10.1007/S10555-007-9061-3  0.646
2007 Bindra RS, Glazer PM. Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network. Cancer Letters. 252: 93-103. PMID 17275176 DOI: 10.1016/J.Canlet.2006.12.011  0.619
2007 Huang LE, Bindra RS, Glazer PM, Harris AL. Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression. Journal of Molecular Medicine (Berlin, Germany). 85: 139-48. PMID 17180667 DOI: 10.1007/S00109-006-0133-6  0.586
2007 Bindra RS, Glazer PM. Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene. 26: 2048-57. PMID 17001309 DOI: 10.1038/Sj.Onc.1210001  0.615
2006 Bindra RS, Glazer PM. Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. Cancer Biology & Therapy. 5: 1400-7. PMID 17106239 DOI: 10.4161/Cbt.5.10.3454  0.58
2006 Gibson SL, Bindra RS, Glazer PM. CHK2-dependent phosphorylation of BRCA1 in hypoxia. Radiation Research. 166: 646-51. PMID 17007555 DOI: 10.1667/Rr0660.1  0.782
2006 Bindra R, Gibson S, Crosby M, Glazer P. 86 International Journal of Radiation Oncology*Biology*Physics. 66: S50. DOI: 10.1016/J.Ijrobp.2006.07.116  0.738
2005 Bindra RS, Schaffer PJ, Meng A, Woo J, Måseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG, Glazer PM. Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instability. Annals of the New York Academy of Sciences. 1059: 184-95. PMID 16382054 DOI: 10.1196/Annals.1339.049  0.64
2005 Bindra RS, Gibson SL, Meng A, Westermark U, Jasin M, Pierce AJ, Bristow RG, Classon MK, Glazer PM. Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Research. 65: 11597-604. PMID 16357170 DOI: 10.1158/0008-5472.Can-05-2119  0.78
2005 Gibson SL, Bindra RS, Glazer PM. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Research. 65: 10734-41. PMID 16322218 DOI: 10.1158/0008-5472.Can-05-1160  0.787
2005 Meng AX, Jalali F, Cuddihy A, Chan N, Bindra RS, Glazer PM, Bristow RG. Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 76: 168-76. PMID 16026872 DOI: 10.1016/J.Radonc.2005.06.025  0.582
2005 Bindra RS, Glazer PM. Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis. Mutation Research. 569: 75-85. PMID 15603753 DOI: 10.1016/J.Mrfmmm.2004.03.013  0.605
2005 Bristow R, Meng A, Jalali F, Hedley D, Nichol T, Sweet J, Milosevic M, Bindra R, Glazer P. 67 Expression of DNA-dsb repair proteins is altered under hypoxia in prostate cancer cells Radiotherapy and Oncology. 76: S20-S21. DOI: 10.1016/S0167-8140(05)80228-2  0.579
2005 Glazer P, Bindra R. Dysregulation of BRCAL in Hypoxia International Journal of Radiation Oncology*Biology*Physics. 63: S145. DOI: 10.1016/J.Ijrobp.2005.07.247  0.503
2004 Bindra RS, Schaffer PJ, Meng A, Woo J, Måseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG, Glazer PM. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Molecular and Cellular Biology. 24: 8504-18. PMID 15367671 DOI: 10.1128/Mcb.24.19.8504-8518.2004  0.649
2003 Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson RS, Rockwell S, Glazer PM. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Molecular and Cellular Biology. 23: 3265-73. PMID 12697826 DOI: 10.1128/Mcb.23.9.3265-3273.2003  0.748
Low-probability matches (unlikely to be authored by this person)
2013 Rutter C, Giesen E, Yu J, Bindra R, Kluger H, Chiang V. Influence of BRAF and NRAS Mutations on Distant Intracranial Recurrence and Survival in Metastatic Melanoma Following Radiosurgery International Journal of Radiation Oncology*Biology*Physics. 87: S275. DOI: 10.1016/J.Ijrobp.2013.06.717  0.296
2016 Corso CD, Bindra RS. Success and Failures of Combined Modalities in Glioblastoma Multiforme: Old Problems and New Directions. Seminars in Radiation Oncology. 26: 281-98. PMID 27619250 DOI: 10.1016/J.Semradonc.2016.06.003  0.294
2014 Cuaron J, Yahalom J, Sundaram R, Katz S, Wang G, Sharma M, Yau P, Bindra R. Identification of Gene Expression Signatures to Predict the Response of Low-Grade Lymphomas to Very Low Dose Radiation Therapy International Journal of Radiation Oncology*Biology*Physics. 90: S153. DOI: 10.1016/J.Ijrobp.2014.05.633  0.293
2011 Bindra R, Glickman F, Powell S. Small Molecule Screening for Novel Double-strand Break Repair Inhibitors using High-throughput Flow Cytometry International Journal of Radiation Oncology*Biology*Physics. 81: S54. DOI: 10.1016/J.Ijrobp.2011.06.109  0.291
2016 Kann BH, Yu JB, Stahl JM, Bond JE, Loiselle C, Chiang VL, Bindra RS, Gerrard JL, Carlson DJ. The impact of cobalt-60 source age on biologically effective dose in high-dose functional Gamma Knife radiosurgery. Journal of Neurosurgery. 125: 154-159. PMID 27903196 DOI: 10.3171/2016.6.Gks161497  0.288
2015 van Dams R, Park HS, Alomari AK, Ricciardi AS, Rao H, McNamara J, DiLuna ML, Bindra RS. Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report. Journal of Neurosurgery. Pediatrics. 1-5. PMID 26636250 DOI: 10.3171/2015.8.Peds15313  0.284
2021 Leelatian N, Hong CS, Bindra RS. The Role of Mismatch Repair in Glioblastoma Multiforme Treatment Response and Resistance. Neurosurgery Clinics of North America. 32: 171-180. PMID 33781500 DOI: 10.1016/j.nec.2020.12.009  0.284
2016 Gaudin A, Song E, King AR, Saucier-Sawyer JK, Bindra R, Desmaële D, Couvreur P, Saltzman WM. PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma. Biomaterials. 105: 136-144. PMID 27521616 DOI: 10.1016/J.Biomaterials.2016.07.037  0.284
2019 Jairam V, Kann BH, Park HS, Miccio JA, Beckta JM, Yu JB, Prabhu RS, Gao SJ, Mehta MP, Curran WJ, Bindra RS, Contessa JN, Patel KR. Defining an Intermediate-risk Group for Low-grade Glioma: A National Cancer Database Analysis. Anticancer Research. 39: 2911-2918. PMID 31177129 DOI: 10.21873/Anticanres.13420  0.283
2019 Yu JB, Singh C, Bindra RS, Contessa JN, Husain Z, Hansen JE, Park HS, Roberts KB, Bond JE, Tien CJ, Guo F, Colaco RJ, Housri N, Magnuson WJ, Mahajan A, et al. Results of a pilot/phase II study of gamma knife radiosurgery for brain metastases and implications for future prospective clinical trials Journal of Radiation Oncology. 8: 39-46. DOI: 10.1007/S13566-018-0370-7  0.283
2011 Mutter R, Bindra R, Park J, Powell S. Identification of Homologous Recombination (HR) Defects and Biomarkers of Response in Sporadic Breast Cancer (BC) International Journal of Radiation Oncology*Biology*Physics. 81: S26-S27. DOI: 10.1016/J.Ijrobp.2011.06.055  0.282
2015 Jairam V, Rutter CE, Yu JB, Bindra RS. Change in radiotherapy treatment volumes with initial alkylating chemotherapy in anaplastic gliomas Journal of Radiation Oncology. 4: 163-167. DOI: 10.1007/S13566-015-0193-8  0.282
2019 Fomchenko EI, Erson-Omay EZ, Zhao A, Bindra RS, Huttner A, Fulbright RK, Moliterno J. co-mutation in an -mutant glioblastoma. Cold Spring Harbor Molecular Case Studies. 5. PMID 31371348 DOI: 10.1101/mcs.a004119  0.282
2014 Wang C, Roberts KB, Bindra RS, Chiang VL, Yu JB. Delayed cerebral vasculopathy following cranial radiation therapy for pediatric tumors. Pediatric Neurology. 50: 549-56. PMID 24739378 DOI: 10.1016/J.Pediatrneurol.2013.09.018  0.281
1997 Simon DB, Bindra RS, Mansfield TA, Nelson-Williams C, Mendonca E, Stone R, Schurman S, Nayir A, Alpay H, Bakkaloglu A, Rodriguez-Soriano J, Morales JM, Sanjad SA, Taylor CM, Pilz D, et al. Mutations in the chloride channel gene, CLCNKB, cause Bartter's syndrome type III. Nature Genetics. 17: 171-8. PMID 9326936 DOI: 10.1038/Ng1097-171  0.279
2014 Jairam V, Rutter C, Yu J, Bindra R. Change in Radiation Therapy Treatment Volumes With Initial Alkylating Chemotherapy in WHO Grade 3 Gliomas International Journal of Radiation Oncology*Biology*Physics. 90: S293. DOI: 10.1016/J.Ijrobp.2014.05.988  0.277
2016 Lester-Coll NH, Kluytenaar J, Pavlik KF, Yu JB, Contessa JN, Moliterno J, Piepmeier J, Becker KP, Baehring J, Huttner AJ, Vortmeyer AO, Ramani R, Lampert RJ, Yao X, Bindra RS. Mibefradil Dihydrochloride With Hypofractionated Radiation for Recurrent Glioblastoma: Preliminary Results of a Phase 1 Dose Expansion Trial. International Journal of Radiation Oncology, Biology, Physics. 96: S93. PMID 27676055 DOI: 10.1016/J.Ijrobp.2016.06.233  0.276
2020 Grossman SA, Romo CG, Rudek MA, Supko J, Fisher J, Nabors LB, Wen PY, Peereboom DM, Ellingson BM, Elmquist W, Barker FG, Kamson D, Sarkaria JN, Timmer W, Bindra RS, et al. Baseline Requirements for Novel Agents Being Considered for Phase II/III Brain Cancer Efficacy Trials:Conclusions from the Adult Brain Tumor Consortium's First Workshop on CNS Drug Delivery. Neuro-Oncology. PMID 32506123 DOI: 10.1093/Neuonc/Noaa142  0.275
2015 Park H, Yeboa D, Lester-Coll N, Corso C, Mancini B, Bindra R, Roberts K, Yu J, Rutter C. Pediatric Brainstem Glioma Survival After Definitive Radiation Therapy With or Without Concurrent Chemotherapy: A Nationwide Comparison International Journal of Radiation Oncology*Biology*Physics. 93: E504-E505. DOI: 10.1016/J.Ijrobp.2015.07.1836  0.275
2019 Liang J, Beckta JM, Bindra RS. Re: Catherine H. Marshall, Alexandra O. Sokolova, Andrea L. McNatty, et al. Differential Response to Olaparib Treatment Among Men with Metastatic Castration-resistant Prostate Cancer Harboring BRCA1 or BRCA2 Versus ATM Mutations. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2019.02.002. European Urology. PMID 31080125 DOI: 10.1016/J.Eururo.2019.04.041  0.274
2017 Chowdhary M, Okwan-Duodu D, Switchenko JM, Press RH, Jhaveri J, Buchwald ZS, Zhong J, Chapman BV, Bindra RS, Contessa JN, Park HS, Yu JB, Decker RH, Olson JJ, Oyesiku NM, et al. Angiotensin receptor blockade: a novel approach for symptomatic radiation necrosis after stereotactic radiosurgery. Journal of Neuro-Oncology. PMID 29124649 DOI: 10.1007/S11060-017-2652-0  0.273
2017 Corso CD, Bindra RS, Mehta MP. The role of radiation in treating glioblastoma: here to stay. Journal of Neuro-Oncology. PMID 28271281 DOI: 10.1007/S11060-016-2348-X  0.273
2023 Cecchini M, Zhang JY, Wei W, Sklar J, Lacy J, Zhong M, Kong Y, Zhao H, DiPalermo J, Devine L, Stein SM, Kortmansky J, Johung KL, Bindra RS, LoRusso P, et al. Quantitative DNA Repair Biomarkers and Immune Profiling for Temozolomide and Olaparib in Metastatic Colorectal Cancer. Cancer Research Communications. 3: 1132-1139. PMID 37387791 DOI: 10.1158/2767-9764.CRC-23-0045  0.273
2019 Jackson C, Kalathil A, Sundaram R, Bindra R. Temozolomide-Resistant Glioma Cells Are Sensitive to Chloroethylating Nitrosourea Compounds in Combination with ATR Inhibitors International Journal of Radiation Oncology*Biology*Physics. 105: E639. DOI: 10.1016/J.Ijrobp.2019.06.1098  0.273
2017 Chen WS, Bindra R, Mo A, Hayman T, Husain Z, Contessa JN, Gaffney SG, Townsend JP, Yu JB. CDKN2A copy number loss in HPV- and HPV+ head and neck cancer to indicate poor prognosis: An integrated genomic and clinical TCGA analysis. Journal of Clinical Oncology. 35: 6060-6060. DOI: 10.1200/Jco.2017.35.15_Suppl.6060  0.272
2022 Jo U, Murai Y, Agama KK, Sun Y, Saha LK, Yang X, Arakawa Y, Gayle S, Jones K, Paralkar V, Sundaram RK, Van Doorn J, Vasquez JC, Bindra RS, Choi WS, et al. TOP1-DNA trapping by exatecan and combination therapy with ATR inhibitor. Molecular Cancer Therapeutics. PMID 35439320 DOI: 10.1158/1535-7163.MCT-21-1000  0.272
2017 Braunstein S, Raleigh D, Bindra R, Mueller S, Haas-Kogan D. Pediatric high-grade glioma: current molecular landscape and therapeutic approaches. Journal of Neuro-Oncology. PMID 28357536 DOI: 10.1007/S11060-017-2393-0  0.272
2014 Colaco R, Martin P, Bond J, Bindra R, Contessa J, Kluger H, Yu J, Chiang V. BM-10 * SYSTEMIC TREATMENT AND RADIATION NECROSIS FOLLOWING GKSRS IN THE TREATMENT OF BRAIN METASTASES Neuro-Oncology. 16: v34-v34. DOI: 10.1093/Neuonc/Nou240.10  0.272
2011 Bindra RS, Yahalom J. The important role of radiation therapy in early-stage diffuse large B-cell lymphoma: time to review the evidence once again. Expert Review of Anticancer Therapy. 11: 1367-78. PMID 21929311 DOI: 10.1586/Era.11.88  0.27
2018 Jackson C, Noorbakhsh S, Bindra R. Elucidation of an Exquisite Synergistic Interaction Between ATR Inhibitors and Alkylating Agents in MGMT-Methylated Glioma Cells International Journal of Radiation Oncology*Biology*Physics. 102: e226-e227. DOI: 10.1016/J.Ijrobp.2018.07.774  0.27
2017 Fons N, Sundaram R, Surovtseva Y, Rusin S, Kettenbach A, Breuer G, Bindra R. DIPG-33. BIOLOGICAL CHARACTERIZATION OF PPM1D MUTATIONS IN THE CONTEXT OF DIPG Neuro-Oncology. 19: iv12-iv12. DOI: 10.1093/Neuonc/Nox083.048  0.269
2020 van den Bent MJ, Mellinghoff IK, Bindra RS. Gray Areas in the Gray Matter: Mutations in Glioma. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. 40: 1-8. PMID 32186930 DOI: 10.1200/EDBK_280967  0.267
2020 Shuch B, Li S, Risch H, Bindra RS, McGillivray PD, Gerstein M. Estimation of the carrier frequency of fumarate hydratase alterations and implications for kidney cancer risk in hereditary leiomyomatosis and renal cancer. Cancer. PMID 32413184 DOI: 10.1002/Cncr.32914  0.266
2018 Jairam V, Kann B, Park H, Miccio J, Beckta J, Yu J, Gao S, Prabhu R, Mehta M, Curran W, Bindra R, Contessa J, Patel K. Defining an Intermediate Risk Group for Low Grade Glioma? An Analysis of the National Cancer Database International Journal of Radiation Oncology*Biology*Physics. 102: e249-e250. DOI: 10.1016/J.Ijrobp.2018.07.827  0.265
2022 Gueble SE, Vasquez JC, Bindra RS. The Role of PARP Inhibitors in Patients with Primary Malignant Central Nervous System Tumors. Current Treatment Options in Oncology. 23: 1566-1589. PMID 36242713 DOI: 10.1007/s11864-022-01024-5  0.265
2015 Yeboa D, Rutter C, Park H, Lester-Coll N, Corso C, Mancini B, Bindra R, Yu J. Concurrent Chemoradiation Therapy Is Associated With Improved Survival Compared to Radiation Therapy Alone for Anaplastic Gliomas International Journal of Radiation Oncology*Biology*Physics. 93: S168. DOI: 10.1016/J.Ijrobp.2015.07.404  0.263
2016 Kann BH, Lester-Coll NH, Park HS, Yeboa DN, Bindra RS, Becker KP, Baehring J, Roberts KB. Addition of Chemotherapy to Adjuvant Radiation Therapy is Associated With Improved Overall Survival in Adult Medulloblastoma. International Journal of Radiation Oncology, Biology, Physics. 96: S27-S28. PMID 27675888 DOI: 10.1016/J.Ijrobp.2016.06.080  0.263
2019 Seo YE, Suh HW, Bahal R, Josowitz A, Zhang J, Song E, Cui J, Noorbakhsh S, Jackson C, Bu T, Piotrowski-Daspit A, Bindra R, Saltzman WM. Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma. Biomaterials. 201: 87-98. PMID 30802686 DOI: 10.1016/J.Biomaterials.2019.02.016  0.262
2020 Bindra RS. Penetrating the Brain Tumor Space with DNA Damage Response Inhibitors. Neuro-Oncology. PMID 33059370 DOI: 10.1093/neuonc/noaa228  0.261
2018 Fons N, Sundaram R, Breuer G, Brenner C, Bindra R. PDTM-22. TARGETING A NOVEL METABOLIC DEFECT IN PPM1D-MUTANT DIFFUSE INTRINSIC PONTINE GLIOMAS Neuro-Oncology. 20: vi208-vi208. DOI: 10.1093/Neuonc/Noy148.864  0.26
2013 Rutter C, Mancini B, Yu J, Chiang V, Bindra R. Prognostic Factors in Patients With Brain Metastases at Initial Non-Small Cell Lung Cancer Diagnosis International Journal of Radiation Oncology*Biology*Physics. 87: S273. DOI: 10.1016/J.Ijrobp.2013.06.711  0.258
2018 Chen EM, Quijano AR, Seo YE, Jackson C, Josowitz AD, Noorbakhsh S, Merlettini A, Sundaram RK, Focarete ML, Jiang Z, Bindra RS, Saltzman WM. Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors. Biomaterials. 178: 193-203. PMID 29936153 DOI: 10.1016/J.Biomaterials.2018.06.024  0.255
2015 Yeboa D, Park H, Rutter C, Mancini B, Corso C, Lester-Coll N, Bindra R, Yu J. Practice Patterns of Concurrent Chemoradiation Therapy Compared to Radiation Therapy Alone for Low Grade Gliomas International Journal of Radiation Oncology*Biology*Physics. 93: E73. DOI: 10.1016/J.Ijrobp.2015.07.730  0.253
2018 Chen WS, Bindra RS, Mo A, Hayman T, Husain Z, Contessa JN, Gaffney SG, Townsend JP, Yu JB. CDKN2A Copy Number Loss Is an Independent Prognostic Factor in HPV-Negative Head and Neck Squamous Cell Carcinoma. Frontiers in Oncology. 8: 95. PMID 29670856 DOI: 10.3389/Fonc.2018.00095  0.253
2017 Chang K, Bai HX, Zhou H, Su C, Bi WL, Agbodza E, Kavouridis VK, Senders JT, Boaro A, Beers AL, Zhang B, Capellini A, Liao W, Shen Q, Li X, ... ... Bindra RS, et al. Residual Convolutional Neural Network for Determination of IDH Status in Low- and High-grade Gliomas from MR Imaging. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29167275 DOI: 10.1158/1078-0432.Ccr-17-2236  0.25
2022 Ganesa S, Sule A, Sundaram RK, Bindra RS. Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma. Scientific Reports. 12: 5827. PMID 35388070 DOI: 10.1038/s41598-022-09614-x  0.248
2016 Kann BH, Park HS, Lester-Coll NH, Yeboa DN, Benitez V, Bindra RS, Khan AJ, Marks AM, Roberts KB. Adjuvant Radiation Therapy Patterns and Survival Implications for Medulloblastoma in Young Children. International Journal of Radiation Oncology, Biology, Physics. 96: S230-S231. PMID 27675855 DOI: 10.1016/J.Ijrobp.2016.06.573  0.247
2020 Cicconi A, Rai R, Xiong X, Broton C, Al-Hiyasat A, Hu C, Dong S, Sun W, Garbarino J, Bindra RS, Schildkraut C, Chen Y, Chang S. Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly. Nature Communications. 11: 5861. PMID 33203878 DOI: 10.1038/s41467-020-19674-0  0.247
2018 Jairam V, Kann B, Patel K, Yu J, Hansen J, Husain Z, Bindra R, Contessa J, Omay S, Chiang V, Park H. Evolving National Practice Patterns of Hypofractionated Stereotactic Radiation Therapy Versus Single-Fraction Radiosurgery for Brain Metastases International Journal of Radiation Oncology*Biology*Physics. 102: e227. DOI: 10.1016/J.Ijrobp.2018.07.775  0.244
2017 Bindra RS, Galanis E, Mehta MP. State of the art: the evolving role of RT in combined modality therapy for GBM. Journal of Neuro-Oncology. PMID 28913783 DOI: 10.1007/S11060-017-2596-4  0.244
2015 Kole A, Yeboa D, Rutter C, Lester-Coll N, Corso C, Mancini B, Bindra R, Yu J, Park H. Survival Benefit of Concurrent Chemoradiation Therapy for Unresected Glioblastoma Multiforme in the Temozolomide Era International Journal of Radiation Oncology*Biology*Physics. 93: E64. DOI: 10.1016/J.Ijrobp.2015.07.706  0.241
2019 Gao S, Corbin Z, Moliterno J, Bindra R, Yu JB, Park HS, Contessa J. Radiotherapy Timing Following Biopsy and Its Effect on Overall Survival in Unresected Glioblastoma Multiforme International Journal of Radiation Oncology*Biology*Physics. 103: E26. DOI: 10.1016/S0360-3016(19)30459-6  0.24
2014 Colaco R, Martin P, Bond J, Bindra R, Contessa J, Kluger H, Yu J, Chiang V. Systemic Treatment and Radiation Necrosis Following Gamma Knife Radiosurgery in the Treatment of Brain Metastases International Journal of Radiation Oncology*Biology*Physics. 90: S310. DOI: 10.1016/J.Ijrobp.2014.05.1035  0.239
2022 Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, ... Bindra RS, et al. In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2. Leukemia. PMID 35273342 DOI: 10.1038/s41375-022-01536-x  0.234
2017 Yeboa DN, Rutter CE, Park HS, Lester-Coll NH, Corso CD, Mancini BR, Bindra RS, Contessa J, Yu JB. Patterns of care and outcomes for use of concurrent chemoradiotherapy over radiotherapy alone for anaplastic gliomas. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 29054377 DOI: 10.1016/J.Radonc.2017.09.027  0.234
2016 Corso CD, King AR, Saltzman WM, Bindra RS. Convection-Enhanced Delivery of Nanoparticle-Encapsulated Radiosensitizers for Treatment of Malignant Glioma. International Journal of Radiation Oncology, Biology, Physics. 96: E573. PMID 27675051 DOI: 10.1016/J.Ijrobp.2016.06.2063  0.233
2022 Gajjar A, Mahajan A, Abdelbaki M, Anderson C, Antony R, Bale T, Bindra R, Bowers DC, Cohen K, Cole B, Dorris K, Ermoian R, Franson A, Helgager J, Landi D, et al. Pediatric Central Nervous System Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : Jnccn. 20: 1339-1362. PMID 36509072 DOI: 10.6004/jnccn.2022.0062  0.233
2021 Talele S, Zhang W, Burgenske DM, Kim M, Mohammad AS, Dragojevic S, Gupta SK, Bindra RS, Sarkaria JN, Elmquist WF. Brain distribution of berzosertib: an ATR inhibitor for the treatment of glioblastoma. The Journal of Pharmacology and Experimental Therapeutics. PMID 34556535 DOI: 10.1124/jpet.121.000845  0.233
2016 Kann BH, Lester-Coll NH, Park HS, Yeboa DN, Kelly JR, Baehring JM, Becker KP, Yu JB, Bindra RS, Roberts KB. Adjuvant chemotherapy and overall survival in adult medulloblastoma. Neuro-Oncology. PMID 27540083 DOI: 10.1093/Neuonc/Now150  0.232
2021 Gupta GP, Bindra RS. Introduction: Progress Towards Genomically-directed Radiosensitization. Seminars in Radiation Oncology. 32: 1-2. PMID 34861991 DOI: 10.1016/j.semradonc.2021.09.009  0.232
2017 King AR, Corso CD, Chen EM, Song E, Bongiorni P, Chen Z, Sundaram RK, Bindra RS, Saltzman WM. Local DNA repair inhibition for sustained radiosensitization in high grade gliomas. Molecular Cancer Therapeutics. PMID 28566437 DOI: 10.1158/1535-7163.MCT-16-0788  0.232
2023 Doroshow DB, Wei W, Mehrotra M, Sia D, Eder JP, Bindra R, Houldsworth J, LoRusso P, Walther Z. Platinum Sensitivity in Mutated Intrahepatic Cholangiocarcinoma: Not All "BRCAness" Is Created Equal. Cancer Investigation. 1-10. PMID 37505929 DOI: 10.1080/07357907.2023.2242957  0.231
2024 Murray MA, Noronha KJ, Wang Y, Friedman AP, Paradkar S, Suh HW, Sundaram RK, Brenner C, Saltzman WM, Bindra RS. Exploiting Metabolic Defects in Glioma with Nanoparticle Encapsulated NAMPT Inhibitors. Molecular Cancer Therapeutics. PMID 38691846 DOI: 10.1158/1535-7163.MCT-24-0012  0.23
2017 Chen WS, Bindra RS, Mo A, Hayman T, Husain Z, Contessa JN, Yu JB. (S032) Investigating CDKN2A Copy Number Loss in HPV- and HPV+ Head and Neck Cancer: A Demonstration of Integrated Genomic and Clinical Analyses Using TCGA International Journal of Radiation Oncology*Biology*Physics. 98: E10. DOI: 10.1016/J.Ijrobp.2017.02.068  0.229
2016 King A, Corso C, Bindra R, Saltzman WM. HG-112LOCAL DELIVERY OF RADIOSENSITIZING NANOPARTICLES FOR THE TREATMENT OF PEDIATRIC BRAINSTEM GLIOMAS Neuro-Oncology. 18: iii74.3-iii74. DOI: 10.1093/Neuonc/Now073.108  0.227
2019 Bao X, Wu J, Shuch B, LoRusso P, Bindra RS, Li J. Quantitative Profiling of Oncometabolites in Frozen and Formalin-Fixed Paraffin-Embedded Tissue Specimens by Liquid Chromatography Coupled with Tandem Mass Spectrometry. Scientific Reports. 9: 11238. PMID 31375752 DOI: 10.1038/S41598-019-47669-5  0.226
2013 Corso C, Bindra R, Yu J, Contessa J. Factors Predicting Survival in Grade 1-3 Astrocytomas International Journal of Radiation Oncology*Biology*Physics. 87: S253-S254. DOI: 10.1016/J.Ijrobp.2013.06.659  0.224
2018 Yu J, Singh C, Bindra R, Contessa J, Husain Z, Hansen J, Park H, Roberts K, Bond J, Tien C, Guo F, Colaco R, Housri N, Magnuson W, Omay B, et al. A Pilot/Phase II Study of Stereotactic Radiosurgery for Brain Metastases Using Rational Dose Selection International Journal of Radiation Oncology*Biology*Physics. 102: e372-e373. DOI: 10.1016/J.Ijrobp.2018.07.1113  0.219
2016 Kann BH, Park HSM, Lester-Coll NH, Yeboa DN, Benitez V, Bindra R, Khan AJ, Marks AM, Roberts K. MB-38ADJUVANT RADIOTHERAPY PATTERNS OF CARE AND SURVIVAL IMPLICATIONS FOR MEDULLOBLASTOMA IN YOUNG CHILDREN Neuro-Oncology. 18: iii105.2-iii105. DOI: 10.1093/Neuonc/Now076.36  0.217
2015 Jairam V, Rutter C, Yu J, Contessa J, Bindra R. Molecular Characteristics and Overall Survival for Grade III Gliomas International Journal of Radiation Oncology*Biology*Physics. 93: E57. DOI: 10.1016/J.Ijrobp.2015.07.687  0.215
2016 Kann BH, Park HS, Lester-Coll NH, Yeboa DN, Benitez V, Khan AJ, Bindra RS, Marks AM, Roberts KB. Postoperative Radiotherapy Patterns of Care and Survival Implications for Medulloblastoma in Young Children. Jama Oncology. PMID 27491009 DOI: 10.1001/Jamaoncol.2016.2547  0.214
2013 Dosoretz A, Aneja S, Contessa J, Bindra R, Chiang V, Yu J. Long-term Survivors After Treatment of Intracranial Metastases With Radiosurgery International Journal of Radiation Oncology*Biology*Physics. 87: S276. DOI: 10.1016/J.Ijrobp.2013.06.721  0.212
2016 Kann BH, Yu JB, Bond J, Loiselle C, Chiang VL, Bindra RS, Gerrard JL, Carlson DJ. The Impact of Cobalt-60 Source Age on Biologically Effective Dose in Stereotactic Radiosurgery Thalamotomy. International Journal of Radiation Oncology, Biology, Physics. 96: E563. PMID 27675024 DOI: 10.1016/J.Ijrobp.2016.06.2038  0.211
2014 Colaco R, Yu J, Bond J, Bindra R, Contessa J, Knisely J, Chiang V. Dose Selection Algorithm for Gamma Knife Treatment of Cerebral Metastases: Preliminary Results International Journal of Radiation Oncology*Biology*Physics. 90: S310-S311. DOI: 10.1016/J.Ijrobp.2014.05.1036  0.21
2002 Bindra RS, Vasselli JR, Stearman R, Linehan WM, Klausner RD. VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells. Cancer Research. 62: 3014-9. PMID 12036906  0.21
2019 Ludmir EB, Mahajan A, Ahern V, Ajithkumar T, Alapetite C, Bernier-Chastagner V, Bindra RS, Bishop AJ, Bolle S, Brown PD, Carrie C, Chalmers AJ, Chang EL, Chung C, Dieckmann K, et al. Assembling the brain trust: the multidisciplinary imperative in neuro-oncology. Nature Reviews. Clinical Oncology. PMID 31150024 DOI: 10.1038/S41571-019-0235-Z  0.198
2018 Beckta JM, Bindra RS. The Higher the Grade, the Bigger the Field. International Journal of Radiation Oncology, Biology, Physics. 102: 488-489. PMID 30238899 DOI: 10.1016/J.Ijrobp.2018.08.019  0.195
2019 Gao S, Kann B, Bindra R, Contessa J, Yu J, Aneja S. Deep Neural Networks for Radiographic Risk Stratification of Gliomas International Journal of Radiation Oncology*Biology*Physics. 105: S121. DOI: 10.1016/J.Ijrobp.2019.06.092  0.193
2021 Wang Y, Jiang Y, Wei D, Singh P, Yu Y, Lee T, Zhang L, Mandl HK, Piotrowski-Daspit AS, Chen X, Li F, Li X, Cheng Y, Josowitz A, Yang F, ... ... Bindra RS, et al. Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance. Nature Biomedical Engineering. PMID 34045730 DOI: 10.1038/s41551-021-00728-7  0.185
2022 Miller JJ, Gonzalez Castro LN, McBrayer S, Weller M, Cloughesy T, Portnow J, Andronesi O, Barnholtz-Sloan JS, Baumert BG, Berger MS, Bi WL, Bindra R, Cahill DP, Chang SM, Costello JF, et al. Isocitrate dehydrogenase (IDH) mutant gliomas: A Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions. Neuro-Oncology. PMID 36239925 DOI: 10.1093/neuonc/noac207  0.183
2023 Wang Y, Malik S, Suh HW, Xiao Y, Deng Y, Fan R, Huttner A, Bindra RS, Singh V, Saltzman WM, Bahal R. Anti-seed PNAs targeting multiple oncomiRs for brain tumor therapy. Science Advances. 9: eabq7459. PMID 36753549 DOI: 10.1126/sciadv.abq7459  0.179
2023 Fanucci K, Pilat MJ, Shyr D, Shyr Y, Boerner S, Li J, Durecki D, Drappatz J, Puduvalli V, Lieberman FS, Gonzalez J, Giglio P, Ivy SP, Bindra RS, Omuro A, et al. Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrent and -mutant Glioma. Cancer Research Communications. 3: 192-201. PMID 36968138 DOI: 10.1158/2767-9764.CRC-22-0436  0.177
2020 Nouws J, Wan F, Finnemore E, Roque W, Kim SJ, Bazan IS, Li CX, Sköld CM, Dai Q, Yan X, Chioccioli M, Neumeister V, Britto CJ, Sweasy J, Bindra RS, et al. MicroRNA miR-24-3p reduces DNA damage responses, apoptosis, and susceptibility to chronic obstructive pulmonary disease. Jci Insight. PMID 33290275 DOI: 10.1172/jci.insight.134218  0.164
2022 Josowitz AD, Bindra RS, Saltzman WM. Polymer Nanocarriers for Targeted Local Delivery of Agents in Treating Brain Tumors. Nanotechnology. PMID 36179653 DOI: 10.1088/1361-6528/ac9683  0.152
2023 Xu S, Campbell A, Chiang V, Bindra R, Vasquez J, Pashankar F. Use of stereotactic radiosurgery in treatment of brain metastases from pediatric extracranial solid tumors. Pediatric Blood & Cancer. e30303. PMID 36975152 DOI: 10.1002/pbc.30303  0.15
2017 Mo A, Kann B, Gao S, Bindra R. MGMT Promoter Methylation is a Poor Predictor of Gene Expression in Low Grade Gliomas International Journal of Radiation Oncology*Biology*Physics. 99: S189-S190. DOI: 10.1016/j.ijrobp.2017.06.472  0.146
2016 Rutter CE, Johung KL, Yao X, Lu AY, Jilaveanu LB, Yu JB, Contessa JN, Kluger HM, Chiang VLS, Bindra RS. Demonstration of differential radiosensitivity based upon mutation profile in metastatic melanoma treated with stereotactic radiosurgery. Journal of Radiosurgery and Sbrt. 4: 97-106. PMID 29296434  0.145
2023 Khang M, Lee JH, Lee T, Suh HW, Lee S, Cavaliere A, Rushing A, Geraldo LH, Belitzky E, Rossano S, de Feyter HM, Shin K, Huttner A, Roussel MF, Thomas JL, ... ... Bindra RS, et al. Intrathecal delivery of nanoparticle PARP inhibitor to the cerebrospinal fluid for the treatment of metastatic medulloblastoma. Science Translational Medicine. 15: eadi1617. PMID 37910601 DOI: 10.1126/scitranslmed.adi1617  0.145
2022 Jairam V, Park HS, Yu JB, Bindra RS, Contessa JN, Jethwa KR. Practice Patterns Related to Mitigation of Neurocognitive Decline in Patients Receiving Whole Brain Radiation Therapy. Advances in Radiation Oncology. 7: 100949. PMID 35521071 DOI: 10.1016/j.adro.2022.100949  0.112
2022 Khang M, Bindra RS, Mark Saltzman W. Intrathecal Delivery and its Applications in Leptomeningeal Disease. Advanced Drug Delivery Reviews. 114338. PMID 35561835 DOI: 10.1016/j.addr.2022.114338  0.11
2022 Gao S, Jin L, Moliterno J, Corbin ZA, Bindra RS, Contessa JN, Yu JB, Park HS. Impact of radiotherapy delay following biopsy for patients with unresected glioblastoma. Journal of Neurosurgery. 1-11. PMID 35907197 DOI: 10.3171/2022.5.JNS212761  0.101
2022 Jiang J, Bao X, Yue Y, Schiff D, Bindra R, Li J. Development and validation of a liquid chromatography coupled with tandem mass spectrometry method for determining total and unbound pamiparib in human plasma and brain tumors. Biomedical Chromatography : Bmc. e5478. PMID 35938683 DOI: 10.1002/bmc.5478  0.097
2016 Colaco RJ, Yu JB, Bond JS, Bindra RS, Contessa JN, Knisely JPS, Chiang VL. A contemporary dose selection algorithm for stereotactic radiosurgery in the treatment of brain metastases - An initial report. Journal of Radiosurgery and Sbrt. 4: 43-52. PMID 29296425  0.077
1988 SURI OP, BINDRA RS, SATTI NK, KHAJURIA RK. ChemInform Abstract: Synthesis of Apocynin, a Choleretic Constituent of Picrorhiza kurroa and Its Homologues. Cheminform. 19. DOI: 10.1002/chin.198802365  0.049
1996 Kochar MS, Bindra RS. The additive effects of smoking and hypertension. More reasons to help your patients kick the habit. Postgraduate Medicine. 100: 147-8, 151-4, 159-60. PMID 8917330 DOI: 10.3810/pgm.1996.11.114  0.04
2014 Rutter CE, Yu JB, Carlson DJ, Husain ZA, Zhao S, Picone J, Bindra RS. In regards to decision making for reirradiation of a recurrent intramedullary spinal cord metastasis. Journal of Radiosurgery and Sbrt. 3: 165-168. PMID 29296397  0.015
1988 Bindra R, Satti N, Suri O. Isolation and structures of ellagic acid derivatives from Euphorbia acaulis Phytochemistry. 27: 2313-2315. DOI: 10.1016/0031-9422(88)80150-X  0.01
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