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Diana Mandelker - Publications

Affiliations: 
2010 Johns Hopkins University School of Medicine, Baltimore, MD, United States 
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Franch-Expósito S, Mehine M, Ptashkin RN, Bolton KL, Bandlamudi C, Srinivasan P, Zhang L, Goodell MA, Gedvilaite E, Menghrajani K, Sánchez-Vela P, Mandelker D, Comen E, Norton L, Benayed R, et al. Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors. Jco Precision Oncology. 7: e2300070. PMID 37561983 DOI: 10.1200/PO.23.00070  0.32
2022 Murciano-Goroff YR, Schram AM, Rosen EY, Won H, Gong Y, Noronha AM, Janjigian YY, Stadler ZK, Chang JC, Yang SR, Mandelker D, Offit K, Berger MF, Donoghue MTA, Bandlamudi C, et al. Reversion mutations in germline BRCA1/2-mutant tumors reveal a BRCA-mediated phenotype in non-canonical histologies. Nature Communications. 13: 7182. PMID 36418296 DOI: 10.1038/s41467-022-34109-8  0.466
2022 Ozer M, Ranganathan M, Lecomte N, Schvartzman JM, Walch HS, Chatila WK, Hong J, Carlo MI, Walsh MF, Sheehan M, Mandelker D, Ceyhan-Birsoy O, Maio A, Kemel Y, Iacobuzio-Donahue CA, et al. Concurrent Germline / and Mismatch Repair Mutations in Young-Onset Pancreatic and Colorectal Cancer: The Importance of Comprehensive Germline and Somatic Characterization to Inform Therapeutic Options. Jco Precision Oncology. 6: e2100560. PMID 35675575 DOI: 10.1200/PO.21.00560  0.378
2022 Manning-Geist B, Gordhandas S, Liu YL, Zhou Q, Iasonos A, Da Cruz Paula A, Mandelker D, Long Roche K, Zivanovic O, Maio A, Kemel Y, Chi DS, O'Cearbhaill RE, Aghajanian C, Weigelt B, et al. MAPK pathway genetic alterations are associated with prolonged overall survival in low-grade serous ovarian carcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 35443055 DOI: 10.1158/1078-0432.CCR-21-4183  0.35
2022 El Jabbour T, Misyura M, Cowzer D, Zimmermann M, Rimkunas V, Marra A, Derakhshan F, Selenica P, Parilla M, Setton JS, Ceyhan-Birsoy O, Kemel Y, Catchings A, Ranganathan M, Ku GY, ... ... Mandelker D, et al. ATM Germline Mutated Gastroesophageal Junction Adenocarcinomas: Clinical Descriptors, Molecular Characteristics and Potential Therapeutic Implications. Journal of the National Cancer Institute. PMID 35078243 DOI: 10.1093/jnci/djac024  0.345
2021 Pareja F, Ptashkin RN, Brown DN, Derakhshan F, Selenica P, da Silva EM, Gazzo AM, Da Cruz Paula A, Breen K, Shen R, Marra A, Zehir A, Benayed R, Berger MF, Ceyhan-Birsoy O, ... ... Mandelker D, et al. Cancer Causative Mutations Occurring in Early Embryogenesis. Cancer Discovery. PMID 34949653 DOI: 10.1158/2159-8290.CD-21-1110  0.306
2021 Chui MH, Yang C, Mehta N, Rai V, Zehir A, Momeni Boroujeni A, Ladanyi M, Mandelker D. Somatic intronic TP53 c.375+5G mutations are a recurrent but under-recognized mode of TP53 inactivation. The Journal of Pathology. Clinical Research. PMID 34505757 DOI: 10.1002/cjp2.242  0.389
2021 Stadler ZK, Maio A, Chakravarty D, Kemel Y, Sheehan M, Salo-Mullen E, Tkachuk K, Fong CJ, Nguyen B, Erakky A, Cadoo K, Liu Y, Carlo MI, Latham A, Zhang H, ... ... Mandelker D, et al. Therapeutic Implications of Germline Testing in Patients With Advanced Cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2003661. PMID 34133209 DOI: 10.1200/JCO.20.03661  0.355
2021 Samstein RM, Krishna C, Ma X, Pei X, Lee KW, Makarov V, Kuo F, Chung J, Srivastava RM, Purohit TA, Hoen DR, Mandal R, Setton J, Wu W, Shah R, ... ... Mandelker DL, et al. Mutations in and differentially affect the tumor microenvironment and response to checkpoint blockade immunotherapy. Nature Cancer. 1: 1188-1203. PMID 33834176 DOI: 10.1038/s43018-020-00139-8  0.387
2021 Francis JH, Richards AL, Mandelker DL, Berger MF, Walsh MF, Dunkel IJ, Donoghue MTA, Abramson DH. Molecular Changes in Retinoblastoma beyond : Findings from Next-Generation Sequencing. Cancers. 13. PMID 33466343 DOI: 10.3390/cancers13010149  0.344
2020 Bolton KL, Ptashkin RN, Gao T, Braunstein L, Devlin SM, Kelly D, Patel M, Berthon A, Syed A, Yabe M, Coombs CC, Caltabellotta NM, Walsh M, Offit K, Stadler Z, ... Mandelker D, et al. Cancer therapy shapes the fitness landscape of clonal hematopoiesis. Nature Genetics. PMID 33106634 DOI: 10.1038/s41588-020-00710-0  0.336
2020 Liu YL, Selenica P, Zhou Q, Iasonos A, Callahan M, Feit NZ, Boland J, Vazquez-Garcia I, Mandelker D, Zehir A, Burger RA, Powell DJ, Friedman C, Cadoo K, Grisham R, et al. Mutations, Homologous DNA Repair Deficiency, Tumor Mutational Burden, and Response to Immune Checkpoint Inhibition in Recurrent Ovarian Cancer. Jco Precision Oncology. 4. PMID 32923884 DOI: 10.1200/PO.20.00069  0.377
2020 Chui MH, Momeni Boroujeni A, Mandelker D, Ladanyi M, Soslow RA. Characterization of TP53-wildtype tubo-ovarian high-grade serous carcinomas: rare exceptions to the binary classification of ovarian serous carcinoma. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 32801341 DOI: 10.1038/s41379-020-00648-y  0.446
2020 Fiala E, Kennedy J, Kemel Y, Mauguen A, Mandelker D, Zehir A, Birsoy O, Bouvier N, Maio A, Latham A, Carlo MI, Cadoo KA, Stadler ZK, Robson ME, Shukla NN, et al. Prospective agnostic germline testing in pediatric cancer patients. Journal of Clinical Oncology. 38: 1589-1589. DOI: 10.1200/jco.2020.38.15_suppl.1589  0.358
2020 Stadler ZK, Maio A, Kemel Y, Sheehan M, Salo-Mullen EE, Cadoo KA, Carlo MI, Latham A, Walsh MF, Drilon AE, Berger MF, Solit DB, Birsoy O, Mandelker D, Diaz LA, et al. Targeted therapy based on germline analysis of tumor-normal sequencing (MSK-IMPACT) in a pan-cancer population. Journal of Clinical Oncology. 38: 1500-1500. DOI: 10.1200/jco.2020.38.15_suppl.1500  0.303
2019 Walsh MF, Sacca R, Wildman T, Amoroso K, Kennedy J, Zhang L, Birsoy O, Mandelker D, Steinsnyder Z, Latham A, Carlo MI, Cadoo K, Kemel Y, Robson M, Stadler ZK, et al. Pathogenic Loss-of-Function Germline Mutations in Patients With Solid Tumors. Jco Precision Oncology. 3. PMID 32923861 DOI: 10.1200/PO.19.00230  0.373
2019 Smith ES, Da Cruz Paula A, Cadoo KA, Abu-Rustum NR, Pei X, Brown DN, Ferrando L, Sebastiao APM, Riaz N, Robson ME, Soslow RA, Reis-Filho JS, Mandelker D, Weigelt B. Endometrial Cancers in or Germline Mutation Carriers: Assessment of Homologous Recombination DNA Repair Defects. Jco Precision Oncology. 3. PMID 32914019 DOI: 10.1200/PO.19.00103  0.352
2019 Guo R, DuBoff M, Jayakumaran G, Kris MG, Ladanyi M, Robson ME, Mandelker D, Zauderer MG. Brief Report: Novel Germline Mutations in DNA Damage Repair in Patients with Malignant Pleural Mesotheliomas. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 31887429 DOI: 10.1016/j.jtho.2019.12.111  0.301
2019 Durham BH, Lopez Rodrigo E, Picarsic J, Abramson D, Rotemberg V, De Munck S, Pannecoucke E, Lu SX, Pastore A, Yoshimi A, Mandelker D, Ceyhan-Birsoy O, Ulaner GA, Walsh M, Yabe M, et al. Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms. Nature Medicine. PMID 31768065 DOI: 10.1038/S41591-019-0653-6  0.523
2019 Mandelker D, Kumar R, Pei X, Selenica P, Setton J, Arunachalam S, Ceyhan-Birsoy O, Brown DN, Norton L, Robson ME, Wen HY, Powell S, Riaz N, Weigelt B, Reis-Filho JS. The Landscape of Somatic Genetic Alterations in Breast Cancers from Germline Mutation Carriers. Jnci Cancer Spectrum. 3: pkz027. PMID 31360903 DOI: 10.1093/jncics/pkz027  0.351
2019 Zauderer MG, Jayakumaran G, DuBoff M, Zhang L, Francis JH, Abramson DH, Cercek A, Nash GM, Shoushtari A, Chapman P, D'Angelo S, Arnold AG, Siegel B, Fleischut MH, Ni A, ... ... Mandelker D, et al. Brief Report: Prevalence and Preliminary Validation of Screening Criteria to Identify Carriers of Germline BAP1 Mutations. Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. PMID 31323388 DOI: 10.1016/j.jtho.2019.07.002  0.413
2019 Jonsson P, Bandlamudi C, Cheng ML, Srinivasan P, Chavan SS, Friedman ND, Rosen EY, Richards AL, Bouvier N, Selcuklu SD, Bielski CM, Abida W, Mandelker D, Birsoy O, Zhang L, et al. Tumour lineage shapes BRCA-mediated phenotypes. Nature. PMID 31292550 DOI: 10.1038/s41586-019-1382-1  0.377
2018 Ashley CW, Da Cruz Paula A, Kumar R, Mandelker D, Pei X, Riaz N, Reis-Filho JS, Weigelt B. Analysis of mutational signatures in primary and metastatic endometrial cancer reveals distinct patterns of DNA repair defects and shifts during tumor progression. Gynecologic Oncology. PMID 30415991 DOI: 10.1016/j.ygyno.2018.10.032  0.409
2018 Hechtman JF, Abou Alfa GK, Stadler ZK, Mandelker DL, Roehrl MHA, Zehir A, Vakiani E, Middha S, Klimstra DS, Shia J. Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA. Human Pathology. PMID 30121369 DOI: 10.1016/J.Humpath.2018.08.004  0.381
2018 Dubard Gault M, Mandelker D, DeLair D, Stewart CR, Kemel Y, Sheehan MR, Siegel B, Kennedy J, Marcell V, Arnold A, Al-Ahmadie H, Modak S, Robson M, Shukla N, Roberts S, et al. Germline mutations in children and adults with cancer. Cold Spring Harbor Molecular Case Studies. 4. PMID 30068732 DOI: 10.1101/mcs.a002584  0.433
2018 Carlo MI, Mukherjee S, Mandelker D, Vijai J, Kemel Y, Zhang L, Knezevic A, Patil S, Ceyhan-Birsoy O, Huang KC, Redzematovic A, Coskey DT, Stewart C, Pradhan N, Arnold AG, et al. Prevalence of Germline Mutations in Cancer Susceptibility Genes in Patients With Advanced Renal Cell Carcinoma. Jama Oncology. PMID 29978187 DOI: 10.1001/Jamaoncol.2018.1986  0.339
2018 Weigelt B, Bi R, Kumar R, Blecua P, Mandelker DL, Geyer FC, Pareja F, James PA, Couch FJ, Eccles DM, Blows F, Pharoah P, Li A, Selenica P, et al. The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers. Journal of the National Cancer Institute. PMID 29506079 DOI: 10.1093/jnci/djy028  0.472
2017 Zehir A, Benayed R, Shah RH, Syed A, Middha S, Kim HR, Srinivasan P, Gao J, Chakravarty D, Devlin SM, Hellmann MD, Barron DA, Schram AM, Hameed M, Dogan S, ... ... Mandelker DL, et al. Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nature Medicine. 23: 1004. PMID 28777785 DOI: 10.1038/nm0817-1004c  0.358
2017 Zehir A, Benayed R, Shah RH, Syed A, Middha S, Kim HR, Srinivasan P, Gao J, Chakravarty D, Devlin SM, Hellmann MD, Barron DA, Schram AM, Hameed M, Dogan S, ... ... Mandelker DL, et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nature Medicine. PMID 28481359 DOI: 10.1038/Nm.4333  0.305
2017 Cheng ML, Abida W, Rathkopf DE, Arcila ME, Barron D, Autio KA, Zehir A, Danila DC, Morris MJ, Gopalan A, Reuter VE, Kantoff PW, Slovin SF, Robson ME, Zhang L, ... Mandelker D, et al. Next-generation sequencing (NGS) of tissue and cell free DNA (cfDNA) to identify somatic and germline alterations in advanced prostate cancer. Journal of Clinical Oncology. 35: 5010-5010. DOI: 10.1200/jco.2017.35.15_suppl.5010  0.386
2017 Carlo MI, Zhang L, Mandelker D, Vijai J, Cipolla CK, Robson ME, Funt S, Hakimi AA, Iyer G, Rosenberg JE, Coleman J, Solit DB, Offit K, Bajorin DF. Cancer predisposing germline mutations in patients (pts) with urothelial cancer (UC) of the renal pelvis (R-P), ureter (U) and bladder (B). Journal of Clinical Oncology. 35: 4510-4510. DOI: 10.1200/JCO.2017.35.15_SUPPL.4510  0.367
2010 Gabelli SB, Huang CH, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM. Structural effects of oncogenic PI3Kα mutations Current Topics in Microbiology and Immunology. 347: 43-53. PMID 20593314 DOI: 10.1007/82_2010_53  0.756
2010 Gabelli SB, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM. Somatic mutations in PI3Kα: Structural basis for enzyme activation and drug design Biochimica Et Biophysica Acta - Proteins and Proteomics. 1804: 533-540. PMID 19962457 DOI: 10.1016/J.Bbapap.2009.11.020  0.717
2009 Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane Proceedings of the National Academy of Sciences of the United States of America. 106: 16996-17001. PMID 19805105 DOI: 10.1073/Pnas.0908444106  0.742
2008 Amzel LM, Huang CH, Mandelker D, Lengauer C, Gabelli SB, Vogelstein B. Structural comparisons of class I phosphoinositide 3-kinases Nature Reviews Cancer. 8: 665-669. PMID 18633356 DOI: 10.1038/Nrc2443  0.713
2008 Huang CH, Mandelker D, Gabelli SB, Amzel LM. Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle (Georgetown, Tex.). 7: 1151-6. PMID 18418043 DOI: 10.4161/Cc.7.9.5817  0.768
2008 Gabelli S, Huang C, Mandelker D, Vogelstein B, Amzel L. Structural basis for the effects of PI3Kalpha oncogenic mutations Acta Crystallographica Section a Foundations of Crystallography. 64: C79-C80. DOI: 10.1107/S0108767308097456  0.732
2007 Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations Science. 318: 1744-1748. PMID 18079394 DOI: 10.1126/Science.1150799  0.754
2006 Sjöblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, et al. The consensus coding sequences of human breast and colorectal cancers Science. 314: 268-274. PMID 16959974 DOI: 10.1126/science.1133427  0.433
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