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Phillip Allen Sharp - Publications

Affiliations: 
Biology Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Gene splicing
Website:
http://www.nobelprize.org/nobel_prizes/medicine/laureates/1993/sharp-bio.html
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376 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mahat DB, Tippens ND, Martin-Rufino JD, Waterton SK, Fu J, Blatt SE, Sharp PA. Single-cell nascent RNA sequencing unveils coordinated global transcription. Nature. 631: 216-223. PMID 38839954 DOI: 10.1038/s41586-024-07517-7  0.364
2024 Gupta K, Yang C, McCue K, Bastani O, Sharp PA, Burge CB, Solar-Lezama A. Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing. Genome Biology. 25: 23. PMID 38229106 DOI: 10.1186/s13059-023-03162-x  0.715
2023 Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P. Correction for Song et al., "Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages". Journal of Virology. e0093623. PMID 37830822 DOI: 10.1128/jvi.00936-23  0.57
2023 Mahat DB, Tippens ND, Martin-Rufino JD, Waterton SK, Fu J, Blatt SE, Sharp PA. Single-cell nascent RNA sequencing using click-chemistry unveils coordinated transcription. Biorxiv : the Preprint Server For Biology. PMID 37745427 DOI: 10.1101/2023.09.15.558015  0.365
2023 Insco ML, Abraham BJ, Dubbury SJ, Kaltheuner IH, Dust S, Wu C, Chen KY, Liu D, Bellaousov S, Cox AM, Martin BJE, Zhang T, Ludwig CG, Fabo T, Modhurima R, ... ... Sharp PA, et al. Oncogenic mutations impede nuclear RNA surveillance. Science (New York, N.Y.). 380: eabn7625. PMID 37079685 DOI: 10.1126/science.abn7625  0.31
2021 Sharp PA, Chakraborty AK, Henninger JE, Young RA. RNA in formation and regulation of transcriptional condensates. Rna (New York, N.Y.). PMID 34772787 DOI: 10.1261/rna.078997.121  0.34
2020 Henninger JE, Oksuz O, Shrinivas K, Sagi I, LeRoy G, Zheng MM, Andrews JO, Zamudio AV, Lazaris C, Hannett NM, Lee TI, Sharp PA, Cissé II, Chakraborty AK, Young RA. RNA-Mediated Feedback Control of Transcriptional Condensates. Cell. PMID 33333019 DOI: 10.1016/j.cell.2020.11.030  0.302
2020 Chakraborty M, Hu S, Visness E, Del Giudice M, De Martino A, Bosia C, Sharp PA, Garg S. MicroRNAs organize intrinsic variation into stem cell states. Proceedings of the National Academy of Sciences of the United States of America. PMID 32139605 DOI: 10.1073/Pnas.1920695117  0.312
2020 Whipple AJ, Breton-Provencher V, Jacobs HN, Chitta UK, Sur M, Sharp PA. Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons. Molecular Cell. PMID 32032531 DOI: 10.1016/j.molcel.2020.01.020  0.34
2019 Shrinivas K, Sabari BR, Coffey EL, Klein IA, Boija A, Zamudio AV, Schuijers J, Hannett NM, Sharp PA, Young RA, Chakraborty AK. Enhancer Features that Drive Formation of Transcriptional Condensates. Molecular Cell. 75: 549-561.e7. PMID 31398323 DOI: 10.1016/J.Molcel.2019.07.009  0.381
2019 Guo YE, Manteiga JC, Henninger JE, Sabari BR, Dall'Agnese A, Hannett NM, Spille JH, Afeyan LK, Zamudio AV, Shrinivas K, Abraham BJ, Boija A, Decker TM, Rimel JK, Fant CB, ... ... Sharp PA, et al. Pol II phosphorylation regulates a switch between transcriptional and splicing condensates. Nature. PMID 31391587 DOI: 10.1038/S41586-019-1464-0  0.373
2019 Kelly TJ, Suzuki HI, Zamudio JR, Suzuki M, Sharp PA. Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A. Rna (New York, N.Y.). 25: 1291-1297. PMID 31289130 DOI: 10.1261/rna.071621.119  0.398
2019 Grigelioniene G, Suzuki HI, Taylan F, Mirzamohammadi F, Borochowitz ZU, Ayturk UM, Tzur S, Horemuzova E, Lindstrand A, Weis MA, Grigelionis G, Hammarsjö A, Marsk E, Nordgren A, Nordenskjöld M, ... ... Sharp PA, et al. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. Nature Medicine. PMID 30804514 DOI: 10.1038/S41591-019-0353-2  0.321
2018 Dubbury SJ, Boutz PL, Sharp PA. CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Nature. 564: 141-145. PMID 30487607 DOI: 10.1038/S41586-018-0758-Y  0.389
2018 Sabari BR, Dall'Agnese A, Boija A, Klein IA, Coffey EL, Shrinivas K, Abraham BJ, Hannett NM, Zamudio AV, Manteiga JC, Li CH, Guo YE, Day DS, Schuijers J, Vasile E, ... ... Sharp PA, et al. Coactivator condensation at super-enhancers links phase separation and gene control. Science (New York, N.Y.). PMID 29930091 DOI: 10.1126/Science.Aar3958  0.342
2018 Sharp PA, Clarkson R, Hussain A, Weeks RJ, Morison IM. DNA methylation of hepatic iron sensing genes and the regulation of hepcidin expression. Plos One. 13: e0197863. PMID 29771984 DOI: 10.1371/journal.pone.0197863  0.309
2018 Suzuki HI, Spengler RM, Grigelioniene G, Kobayashi T, Sharp PA. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics. Nature Genetics. PMID 29662165 DOI: 10.1038/s41588-018-0104-1  0.428
2018 Wang G, Chow RD, Ye L, Guzman CD, Dai X, Dong MB, Zhang F, Sharp PA, Platt RJ, Chen S. Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR-mediated direct in vivo screening. Science Advances. 4: eaao5508. PMID 29503867 DOI: 10.1126/Sciadv.Aao5508  0.771
2018 Chiu AC, Suzuki HI, Wu X, Mahat DB, Kriz AJ, Sharp PA. Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP. Molecular Cell. PMID 29398447 DOI: 10.1016/J.Molcel.2018.01.006  0.768
2018 Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO. Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. Elife. 7. PMID 29293084 DOI: 10.7554/Elife.29494  0.695
2017 Nissim L, Wu MR, Pery E, Binder-Nissim A, Suzuki HI, Stupp D, Wehrspaun C, Tabach Y, Sharp PA, Lu TK. Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy. Cell. PMID 29056342 DOI: 10.1016/J.Cell.2017.09.049  0.329
2017 Braun CJ, Stanciu M, Boutz PL, Patterson JC, Calligaris D, Higuchi F, Neupane R, Fenoglio S, Cahill DP, Wakimoto H, Agar NYR, Yaffe MB, Sharp PA, Hemann MT, Lees JA. Coordinated Splicing of Regulatory Detained Introns within Oncogenic Transcripts Creates an Exploitable Vulnerability in Malignant Glioma. Cancer Cell. PMID 28966034 DOI: 10.1016/J.Ccell.2017.08.018  0.354
2017 Chow RD, Guzman CD, Wang G, Schmidt F, Youngblood MW, Ye L, Errami Y, Dong MB, Martinez MA, Zhang S, Renauer P, Bilguvar K, Gunel M, Sharp PA, Zhang F, et al. AAV-mediated direct in vivo CRISPR screen identifies functional suppressors in glioblastoma. Nature Neuroscience. PMID 28805815 DOI: 10.1038/Nn.4620  0.775
2017 JnBaptiste CK, Gurtan AM, Thai KK, Lu V, Bhutkar A, Su MJ, Rotem A, Jacks T, Sharp PA. Corrigendum: Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. Genes & Development. 31: 1066. PMID 28637695 DOI: 10.1101/gad.302513.117  0.778
2017 JnBaptiste CK, Gurtan AM, Thai KK, Lu V, Bhutkar A, Su MJ, Rotem A, Jacks T, Sharp PA. Dicer loss and recovery induce an oncogenic switch driven by transcriptional activation of the oncofetal Imp1-3 family. Genes & Development. 31: 674-687. PMID 28446596 DOI: 10.1101/Gad.296301.117  0.79
2017 Hnisz D, Shrinivas K, Young RA, Chakraborty AK, Sharp PA. A Phase Separation Model for Transcriptional Control. Cell. 169: 13-23. PMID 28340338 DOI: 10.1016/J.Cell.2017.02.007  0.315
2017 Suzuki HI, Young RA, Sharp PA. Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. Cell. 168: 1000-1014.e15. PMID 28283057 DOI: 10.1016/j.cell.2017.02.015  0.339
2017 Loonam CR, O'Dell SD, Sharp PA, Mullen A. Conjugated Linoleic Acid Isomers Exert Differential Effects on an Adipocyte Model of HIV-associated Lipodystrophy. Current Hiv Research. 15: 46-55. PMID 27924729 DOI: 10.2174/1570162X14666161207125948  0.317
2017 Sharp P. Abstract IA22: Non-coding RNA from discovery to therapy Cancer Research. 77. DOI: 10.1158/1538-7445.Epso16-Ia22  0.328
2016 Zhang X, Chen MH, Wu X, Kodani A, Fan J, Doan R, Ozawa M, Ma J, Yoshida N, Reiter JF, Black DL, Kharchenko PV, Sharp PA, Walsh CA. Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex. Cell. 166: 1147-1162.e15. PMID 27565344 DOI: 10.1016/J.Cell.2016.07.025  0.746
2016 Garg S, Sharp PA. GENE EXPRESSION. Single-cell variability guided by microRNAs. Science (New York, N.Y.). 352: 1390-1. PMID 27313022 DOI: 10.1126/Science.Aag1097  0.319
2016 Loonam CR, O'Dell SD, Sharp PA, Mullen A. Microarray Analysis Reveals Altered Lipid and Glucose Metabolism Genes in Differentiated, Ritonavir-Treated 3T3-L1 Adipocytes. Current Hiv Research. 14: 37-46. PMID 26245760 DOI: 10.2174/1570162X13666150806110238  0.315
2016 Sharp PA. Abstract IA01: Divergent transcription and long noncoding RNA in cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-Ia01  0.451
2015 Gosline SJ, Gurtan AM, JnBaptiste CK, Bosson A, Milani P, Dalin S, Matthews BJ, Yap YS, Sharp PA, Fraenkel E. Elucidating MicroRNA Regulatory Networks Using Transcriptional, Post-transcriptional, and Histone Modification Measurements. Cell Reports. PMID 26748710 DOI: 10.1016/J.Celrep.2015.12.031  0.802
2015 Sigova AA, Abraham BJ, Ji X, Molinie B, Hannett NM, Guo YE, Jangi M, Giallourakis CC, Sharp PA, Young RA. Transcription factor trapping by RNA in gene regulatory elements. Science (New York, N.Y.). PMID 26516199 DOI: 10.1126/science.aad3346  0.341
2015 Sharp PA. 1 Keynote address by Nobel Laureate Phillip A. Sharp the 21st century opened with a revolution in RNA biology. Journal of Biomolecular Structure & Dynamics. 33: 1. PMID 26103212 DOI: 10.1080/07391102.2015.1032624  0.377
2015 Ran FA, Cong L, Yan WX, Scott DA, Gootenberg JS, Kriz AJ, Zetsche B, Shalem O, Wu X, Makarova KS, Koonin EV, Sharp PA, Zhang F. In vivo genome editing using Staphylococcus aureus Cas9. Nature. 520: 186-91. PMID 25830891 DOI: 10.1038/Nature14299  0.713
2015 Lieberman J, Sharp PA. Harnessing RNA interference for therapy: the silent treatment. Jama. 313: 1207-8. PMID 25803342 DOI: 10.1001/Jama.2015.1241  0.332
2015 Chen S, Sanjana NE, Zheng K, Shalem O, Lee K, Shi X, Scott DA, Song J, Pan JQ, Weissleder R, Lee H, Zhang F, Sharp PA. Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis. Cell. 160: 1246-60. PMID 25748654 DOI: 10.1016/J.Cell.2015.02.038  0.611
2015 Boutz PL, Bhutkar A, Sharp PA. Detained introns are a novel, widespread class of post-transcriptionally spliced introns. Genes & Development. 29: 63-80. PMID 25561496 DOI: 10.1101/Gad.247361.114  0.46
2015 Gosline SJ, Gurtan AM, JnBaptiste CK, Bosson A, Milani P, Dalin S, Matthews B, Yap YS, Sharp PA, Fraenkel E. Abstract B2-45: Uncovering coordinated regulation of transcription factors by microRNAs using integrated network models Cancer Research. 75. DOI: 10.1158/1538-7445.Compsysbio-B2-45  0.78
2014 Wu X, Kriz AJ, Sharp PA. Target specificity of the CRISPR-Cas9 system. Quantitative Biology. 2: 59-70. PMID 25722925 DOI: 10.1007/s40484-014-0030-x  0.69
2014 Jangi M, Sharp PA. Building robust transcriptomes with master splicing factors. Cell. 159: 487-98. PMID 25417102 DOI: 10.1016/j.cell.2014.09.054  0.322
2014 Platt RJ, Chen S, Zhou Y, Yim MJ, Swiech L, Kempton HR, Dahlman JE, Parnas O, Eisenhaure TM, Jovanovic M, Graham DB, Jhunjhunwala S, Heidenreich M, Xavier RJ, Langer R, ... ... Sharp PA, et al. CRISPR-Cas9 knockin mice for genome editing and cancer modeling. Cell. 159: 440-55. PMID 25263330 DOI: 10.1016/J.Cell.2014.09.014  0.615
2014 Xue W, Chen S, Yin H, Tammela T, Papagiannakopoulos T, Joshi NS, Cai W, Yang G, Bronson R, Crowley DG, Zhang F, Anderson DG, Sharp PA, Jacks T. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature. 514: 380-4. PMID 25119044 DOI: 10.1038/Nature13589  0.625
2014 Dimitrova N, Zamudio JR, Jong RM, Soukup D, Resnick R, Sarma K, Ward AJ, Raj A, Lee JT, Sharp PA, Jacks T. LincRNA-p21 activates p21 in cis to promote Polycomb target gene expression and to enforce the G1/S checkpoint. Molecular Cell. 54: 777-90. PMID 24857549 DOI: 10.1016/J.Molcel.2014.04.025  0.305
2014 Lambert N, Robertson A, Jangi M, McGeary S, Sharp PA, Burge CB. RNA Bind-n-Seq: quantitative assessment of the sequence and structural binding specificity of RNA binding proteins. Molecular Cell. 54: 887-900. PMID 24837674 DOI: 10.1016/J.Molcel.2014.04.016  0.744
2014 Chen S, Xue Y, Wu X, Le C, Bhutkar A, Bell EL, Zhang F, Langer R, Sharp PA. Global microRNA depletion suppresses tumor angiogenesis. Genes & Development. 28: 1054-67. PMID 24788094 DOI: 10.1101/Gad.239681.114  0.78
2014 Wu X, Scott DA, Kriz AJ, Chiu AC, Hsu PD, Dadon DB, Cheng AW, Trevino AE, Konermann S, Chen S, Jaenisch R, Zhang F, Sharp PA. Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells. Nature Biotechnology. 32: 670-6. PMID 24752079 DOI: 10.1038/Nbt.2889  0.809
2014 Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology. 32: 551-3. PMID 24681508 DOI: 10.1038/Nbt.2884  0.594
2014 Jangi M, Boutz PL, Paul P, Sharp PA. Rbfox2 controls autoregulation in RNA-binding protein networks. Genes & Development. 28: 637-51. PMID 24637117 DOI: 10.1101/Gad.235770.113  0.428
2014 Zamudio JR, Kelly TJ, Sharp PA. Argonaute-bound small RNAs from promoter-proximal RNA polymerase II. Cell. 156: 920-34. PMID 24581493 DOI: 10.1016/j.cell.2014.01.041  0.448
2014 Yin H, Xue W, Chen S, Bogorad RL, Benedetti E, Grompe M, Koteliansky V, Sharp PA, Jacks T, Anderson DG. Erratum: Corrigendum: Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype Nature Biotechnology. 32: 952-952. DOI: 10.1038/Nbt0914-952D  0.567
2013 Wu X, Sharp PA. Divergent transcription: a driving force for new gene origination? Cell. 155: 990-6. PMID 24267885 DOI: 10.1016/J.Cell.2013.10.048  0.729
2013 Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA. Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature. 499: 360-3. PMID 23792564 DOI: 10.1038/Nature12349  0.824
2013 Gurtan AM, Ravi A, Rahl PB, Bosson AD, JnBaptiste CK, Bhutkar A, Whittaker CA, Young RA, Sharp PA. Let-7 represses Nr6a1 and a mid-gestation developmental program in adult fibroblasts. Genes & Development. 27: 941-54. PMID 23630078 DOI: 10.1101/Gad.215376.113  0.79
2013 Wilusz JE, Sharp PA. Molecular biology. A circuitous route to noncoding RNA. Science (New York, N.Y.). 340: 440-1. PMID 23620042 DOI: 10.1126/science.1238522  0.715
2013 Gurtan AM, Sharp PA. The role of miRNAs in regulating gene expression networks. Journal of Molecular Biology. 425: 3582-600. PMID 23500488 DOI: 10.1016/j.jmb.2013.03.007  0.311
2013 Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 2876-81. PMID 23382218 DOI: 10.1073/Pnas.1221904110  0.446
2013 Leung AK, Sharp PA. Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities. Advances in Experimental Medicine and Biology. 768: 165-82. PMID 23224970 DOI: 10.1007/978-1-4614-5107-5_10  0.703
2012 Wilusz JE, JnBaptiste CK, Lu LY, Kuhn CD, Joshua-Tor L, Sharp PA. A triple helix stabilizes the 3' ends of long noncoding RNAs that lack poly(A) tails. Genes & Development. 26: 2392-407. PMID 23073843 DOI: 10.1101/Gad.204438.112  0.827
2012 Ravi A, Gurtan AM, Kumar MS, Bhutkar A, Chin C, Lu V, Lees JA, Jacks T, Sharp PA. Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Cancer Cell. 21: 848-55. PMID 22698408 DOI: 10.1016/J.Ccr.2012.04.037  0.347
2012 Ebert MS, Sharp PA. Roles for microRNAs in conferring robustness to biological processes. Cell. 149: 515-24. PMID 22541426 DOI: 10.1016/j.cell.2012.04.005  0.342
2012 Goldberg MS, Sharp PA. Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. The Journal of Experimental Medicine. 209: 217-24. PMID 22271574 DOI: 10.1084/jem.20111487  0.305
2011 Wilusz JE, Whipple JM, Phizicky EM, Sharp PA. tRNAs marked with CCACCA are targeted for degradation. Science (New York, N.Y.). 334: 817-21. PMID 22076379 DOI: 10.1126/Science.1213671  0.674
2011 Zheng GX, Ravi A, Gould GM, Burge CB, Sharp PA. Genome-wide impact of a recently expanded microRNA cluster in mouse. Proceedings of the National Academy of Sciences of the United States of America. 108: 15804-9. PMID 21911408 DOI: 10.1073/Pnas.1112772108  0.687
2011 Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A. MicroRNAs can generate thresholds in target gene expression. Nature Genetics. 43: 854-9. PMID 21857679 DOI: 10.1038/Ng.905  0.371
2011 Medeiros LA, Dennis LM, Gill ME, Houbaviy H, Markoulaki S, Fu D, White AC, Kirak O, Sharp PA, Page DC, Jaenisch R. Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proceedings of the National Academy of Sciences of the United States of America. 108: 14163-8. PMID 21844366 DOI: 10.1073/Pnas.1111241108  0.419
2011 Flynn RA, Almada AE, Zamudio JR, Sharp PA. Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proceedings of the National Academy of Sciences of the United States of America. 108: 10460-5. PMID 21670248 DOI: 10.1073/pnas.1106630108  0.469
2011 Meenhuis A, van Veelen PA, de Looper H, van Boxtel N, van den Berge IJ, Sun SM, Taskesen E, Stern P, de Ru AH, van Adrichem AJ, Demmers J, Jongen-Lavrencic M, Löwenberg B, Touw IP, Sharp PA, et al. MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice. Blood. 118: 916-25. PMID 21628417 DOI: 10.1182/blood-2011-02-336487  0.321
2011 Leung AK, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. Molecular Cell. 42: 489-99. PMID 21596313 DOI: 10.1016/J.Molcel.2011.04.015  0.72
2011 Zheng GX, Ravi A, Calabrese JM, Medeiros LA, Kirak O, Dennis LM, Jaenisch R, Burge CB, Sharp PA. A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. Plos Genetics. 7: e1002054. PMID 21573140 DOI: 10.1371/Journal.Pgen.1002054  0.726
2011 Chaston TB, Matak P, Pourvali K, Srai SK, McKie AT, Sharp PA. Hypoxia inhibits hepcidin expression in HuH7 hepatoma cells via decreased SMAD4 signaling. American Journal of Physiology. Cell Physiology. 300: C888-95. PMID 21289291 DOI: 10.1152/ajpcell.00121.2010  0.337
2011 Leung AK, Young AG, Bhutkar A, Zheng GX, Bosson AD, Nielsen CB, Sharp PA. Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs. Nature Structural & Molecular Biology. 18: 237-44. PMID 21258322 DOI: 10.1038/Nsmb0911-1084A  0.71
2011 Goldberg MS, Xing D, Ren Y, Orsulic S, Bhatia SN, Sharp PA. Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 745-50. PMID 21187397 DOI: 10.1073/Pnas.1016538108  0.307
2010 Creyghton MP, Cheng AW, Welstead GG, Kooistra T, Carey BW, Steine EJ, Hanna J, Lodato MA, Frampton GM, Sharp PA, Boyer LA, Young RA, Jaenisch R. Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proceedings of the National Academy of Sciences of the United States of America. 107: 21931-6. PMID 21106759 DOI: 10.1073/Pnas.1016071107  0.492
2010 Leung AK, Sharp PA. MicroRNA functions in stress responses. Molecular Cell. 40: 205-15. PMID 20965416 DOI: 10.1016/J.Molcel.2010.09.027  0.699
2010 Ebert MS, Sharp PA. Emerging roles for natural microRNA sponges. Current Biology : Cb. 20: R858-61. PMID 20937476 DOI: 10.1016/j.cub.2010.08.052  0.348
2010 Ebert MS, Sharp PA. MicroRNA sponges: progress and possibilities. Rna (New York, N.Y.). 16: 2043-50. PMID 20855538 DOI: 10.1261/rna.2414110  0.309
2010 Singh N, Agrawal A, Leung AK, Sharp PA, Bhatia SN. Effect of nanoparticle conjugation on gene silencing by RNA interference. Journal of the American Chemical Society. 132: 8241-3. PMID 20518524 DOI: 10.1021/Ja102132E  0.698
2010 Rahl PB, Lin CY, Seila AC, Flynn RA, McCuine S, Burge CB, Sharp PA, Young RA. c-Myc regulates transcriptional pause release. Cell. 141: 432-45. PMID 20434984 DOI: 10.1016/J.Cell.2010.03.030  0.812
2009 Agrawal A, Min DH, Singh N, Zhu H, Birjiniuk A, von Maltzahn G, Harris TJ, Xing D, Woolfenden SD, Sharp PA, Charest A, Bhatia S. Functional delivery of siRNA in mice using dendriworms. Acs Nano. 3: 2495-504. PMID 19673534 DOI: 10.1021/Nn900201E  0.353
2009 Seila AC, Core LJ, Lis JT, Sharp PA. Divergent transcription: a new feature of active promoters. Cell Cycle (Georgetown, Tex.). 8: 2557-64. PMID 19597342 DOI: 10.4161/Cc.8.16.9305  0.816
2009 Matak P, Chaston TB, Chung B, Srai SK, McKie AT, Sharp PA. Activated macrophages induce hepcidin expression in HuH7 hepatoma cells. Haematologica. 94: 773-80. PMID 19454498 DOI: 10.3324/haematol.2008.003400  0.305
2009 Sharp PA. The centrality of RNA. Cell. 136: 577-80. PMID 19239877 DOI: 10.1016/j.cell.2009.02.007  0.398
2008 Grishok A, Hoersch S, Sharp PA. RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 105: 20386-91. PMID 19073934 DOI: 10.1073/pnas.0810589105  0.418
2008 Seila AC, Calabrese JM, Levine SS, Yeo GW, Rahl PB, Flynn RA, Young RA, Sharp PA. Divergent transcription from active promoters. Science (New York, N.Y.). 322: 1849-51. PMID 19056940 DOI: 10.1126/Science.1162253  0.83
2008 Neilson JR, Sharp PA. Small RNA regulators of gene expression. Cell. 134: 899-902. PMID 18805079 DOI: 10.1016/J.Cell.2008.09.006  0.41
2008 Stern P, Astrof S, Erkeland SJ, Schustak J, Sharp PA, Hynes RO. A system for Cre-regulated RNA interference in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 13895-900. PMID 18779577 DOI: 10.1073/Pnas.0806907105  0.411
2008 Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, ... ... Sharp PA, et al. Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Cell. 134: 521-33. PMID 18692474 DOI: 10.1016/J.Cell.2008.07.020  0.656
2008 Sandberg R, Neilson JR, Sarma A, Sharp PA, Burge CB. Proliferating cells express mRNAs with shortened 3' untranslated regions and fewer microRNA target sites. Science (New York, N.Y.). 320: 1643-7. PMID 18566288 DOI: 10.1126/Science.1155390  0.733
2008 Seila AC, Sharp PA. Small RNAs tell big stories in Whistler. Nature Cell Biology. 10: 630-3. PMID 18521067 DOI: 10.1038/ncb0608-630  0.807
2008 Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks T. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell. 132: 875-86. PMID 18329372 DOI: 10.1016/J.Cell.2008.02.019  0.415
2007 Calabrese JM, Seila AC, Yeo GW, Sharp PA. RNA sequence analysis defines Dicer's role in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 18097-102. PMID 17989215 DOI: 10.1073/Pnas.0709193104  0.799
2007 Chung B, Matak P, McKie AT, Sharp P. Leptin Increases the Expression of the Iron Regulatory Hormone Hepcidin in HuH7 Human Hepatoma Cells Journal of Nutrition. 137: 2366-2370. PMID 17951471 DOI: 10.1093/Jn/137.11.2366  0.311
2007 Leung AK, Sharp PA. microRNAs: a safeguard against turmoil? Cell. 130: 581-5. PMID 17719533 DOI: 10.1016/J.Cell.2007.08.010  0.698
2007 Ebert MS, Neilson JR, Sharp PA. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nature Methods. 4: 721-6. PMID 17694064 DOI: 10.1038/Nmeth1079  0.446
2007 Wilker EW, van Vugt MA, Artim SA, Huang PH, Petersen CP, Reinhardt HC, Feng Y, Sharp PA, Sonenberg N, White FM, Yaffe MB. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature. 446: 329-32. PMID 17361185 DOI: 10.1038/Nature05584  0.359
2007 Neilson JR, Zheng GX, Burge CB, Sharp PA. Dynamic regulation of miRNA expression in ordered stages of cellular development. Genes & Development. 21: 578-89. PMID 17344418 DOI: 10.1101/Gad.1522907  0.693
2007 Alemán LM, Doench J, Sharp PA. Comparison of siRNA-induced off-target RNA and protein effects. Rna (New York, N.Y.). 13: 385-95. PMID 17237357 DOI: 10.1261/rna.352507  0.407
2007 Schild-Poulter C, Shih A, Tantin D, Yarymowich NC, Soubeyrand S, Sharp PA, Haché RJ. DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage. Oncogene. 26: 3980-8. PMID 17213819 DOI: 10.1038/sj.onc.1210165  0.341
2007 Calabrese JM, Seila AC, Yeo GW, Sharp PA. RNA sequence analysis defines Dicer's role in mouse embryonic stem cells (Proceedings of the National Academy of Science of the United States of America (November 13, 2007) 104, 46, (18097-18102) DOI: 10.1073/pnas.0709193104) Proceedings of the National Academy of Sciences of the United States of America. 104: 21021. DOI: 10.1073/Pnas.0711071105  0.796
2006 Leung AK, Sharp PA. Function and localization of microRNAs in mammalian cells. Cold Spring Harbor Symposia On Quantitative Biology. 71: 29-38. PMID 17381277 DOI: 10.1101/Sqb.2006.71.049  0.711
2006 Calabrese JM, Sharp PA. Characterization of the short RNAs bound by the P19 suppressor of RNA silencing in mouse embryonic stem cells. Rna (New York, N.Y.). 12: 2092-102. PMID 17135486 DOI: 10.1261/rna.224606  0.421
2006 Leung AK, Calabrese JM, Sharp PA. Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proceedings of the National Academy of Sciences of the United States of America. 103: 18125-30. PMID 17116888 DOI: 10.1073/Pnas.0608845103  0.693
2006 Hakre S, Tussie-Luna MI, Ashworth T, Novina CD, Settleman J, Sharp PA, Roy AL. Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Molecular Cell. 24: 301-8. PMID 17052463 DOI: 10.1016/J.Molcel.2006.09.005  0.329
2006 Petersen CP, Bordeleau ME, Pelletier J, Sharp PA. Short RNAs repress translation after initiation in mammalian cells. Molecular Cell. 21: 533-42. PMID 16483934 DOI: 10.1016/J.Molcel.2006.01.031  0.439
2006 Miskevich F, Doench JG, Townsend MT, Sharp PA, Constantine-Paton M. RNA interference of Xenopus NMDAR NR1 in vitro and in vivo. Journal of Neuroscience Methods. 152: 65-73. PMID 16182372 DOI: 10.1016/j.jneumeth.2005.08.010  0.355
2006 Petersen CP, Doench JG, Grishok A, Sharp PA. 19 The Biology of Short RNAs Cold Spring Harbor Monograph Archive. 43: 535-565. DOI: 10.1101/087969739.43.535  0.443
2005 Tantin D, Schild-Poulter C, Wang V, Haché RJ, Sharp PA. The octamer binding transcription factor Oct-1 is a stress sensor. Cancer Research. 65: 10750-8. PMID 16322220 DOI: 10.1158/0008-5472.CAN-05-2399  0.336
2005 Grishok A, Sharp PA. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. Proceedings of the National Academy of Sciences of the United States of America. 102: 17360-5. PMID 16287966 DOI: 10.1073/pnas.0508989102  0.451
2005 Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (New York, N.Y.). 309: 1074-8. PMID 16099986 DOI: 10.1126/Science.1110955  0.678
2005 Houbaviy HB, Dennis L, Jaenisch R, Sharp PA. Characterization of a highly variable eutherian microRNA gene. Rna (New York, N.Y.). 11: 1245-57. PMID 15987809 DOI: 10.1261/Rna.2890305  0.527
2005 Sharp PA. The discovery of split genes and RNA splicing. Trends in Biochemical Sciences. 30: 279-81. PMID 15950867 DOI: 10.1016/j.tibs.2005.04.002  0.348
2005 Neilson JR, Sharp PA. Herpesviruses throw a curve ball: new insights into microRNA biogenesis and evolution. Nature Methods. 2: 252-4. PMID 15782215 DOI: 10.1038/Nmeth0405-252  0.37
2005 Grishok A, Sinskey JL, Sharp PA. Transcriptional silencing of a transgene by RNAi in the soma of C. elegans. Genes & Development. 19: 683-96. PMID 15741313 DOI: 10.1101/gad.1247705  0.432
2004 Lee KB, Sharp PA. Transcription-dependent polyubiquitination of RNA polymerase II requires lysine 63 of ubiquitin. Biochemistry. 43: 15223-9. PMID 15568815 DOI: 10.1021/bi048719x  0.422
2004 Mansfield JH, Harfe BD, Nissen R, Obenauer J, Srineel J, Chaudhuri A, Farzan-Kashani R, Zuker M, Pasquinelli AE, Ruvkun G, Sharp PA, Tabin CJ, McManus MT. MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nature Genetics. 36: 1079-83. PMID 15361871 DOI: 10.1038/Ng1421  0.558
2004 Fairbrother WG, Holste D, Burge CB, Sharp PA. Single nucleotide polymorphism-based validation of exonic splicing enhancers. Plos Biology. 2: E268. PMID 15340491 DOI: 10.1371/Journal.Pbio.0020268  0.682
2004 Novina CD, Sharp PA. The RNAi revolution. Nature. 430: 161-4. PMID 15241403 DOI: 10.1038/430161A  0.315
2004 Ventura A, Meissner A, Dillon CP, McManus M, Sharp PA, Van Parijs L, Jaenisch R, Jacks T. Cre-lox-regulated conditional RNA interference from transgenes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10380-5. PMID 15240889 DOI: 10.1073/Pnas.0403954101  0.68
2004 Fairbrother WG, Yeo GW, Yeh R, Goldstein P, Mawson M, Sharp PA, Burge CB. RESCUE-ESE identifies candidate exonic splicing enhancers in vertebrate exons. Nucleic Acids Research. 32: W187-90. PMID 15215377 DOI: 10.1093/Nar/Gkh393  0.773
2004 Doench JG, Sharp PA. Specificity of microRNA target selection in translational repression. Genes & Development. 18: 504-11. PMID 15014042 DOI: 10.1101/gad.1184404  0.331
2004 Wang VE, Tantin D, Chen J, Sharp PA. B cell development and immunoglobulin transcription in Oct-1-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 101: 2005-10. PMID 14762167 DOI: 10.1073/pnas.0307304101  0.335
2004 Nogueira ML, Wang VE, Tantin D, Sharp PA, Kristie TM. Herpes simplex virus infections are arrested in Oct-1-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 1473-8. PMID 14745036 DOI: 10.1073/pnas.0307300101  0.349
2004 Wang VE, Schmidt T, Chen J, Sharp PA, Tantin D. Embryonic lethality, decreased erythropoiesis, and defective octamer-dependent promoter activation in Oct-1-deficient mice. Molecular and Cellular Biology. 24: 1022-32. PMID 14729950 DOI: 10.1128/MCB.24.3.1022-1032.2004  0.378
2004 Tantin D, Tussie-Luna MI, Roy AL, Sharp PA. Regulation of immunoglobulin promoter activity by TFII-I class transcription factors. The Journal of Biological Chemistry. 279: 5460-9. PMID 14645227 DOI: 10.1074/Jbc.M311177200  0.363
2003 Houbaviy HB, Murray MF, Sharp PA. Embryonic stem cell-specific MicroRNAs. Developmental Cell. 5: 351-8. PMID 12919684 DOI: 10.1016/S1534-5807(03)00227-2  0.309
2003 Song E, Lee SK, Dykxhoorn DM, Novina C, Zhang D, Crawford K, Cerny J, Sharp PA, Lieberman J, Manjunath N, Shankar P. Sustained small interfering RNA-mediated human immunodeficiency virus type 1 inhibition in primary macrophages. Journal of Virology. 77: 7174-81. PMID 12805416 DOI: 10.1128/Jvi.77.13.7174-7181.2003  0.613
2003 Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nature Reviews. Molecular Cell Biology. 4: 457-67. PMID 12778125 DOI: 10.1038/Nrm1129  0.675
2003 Stewart SA, Dykxhoorn DM, Palliser D, Mizuno H, Yu EY, An DS, Sabatini DM, Chen IS, Hahn WC, Sharp PA, Weinberg RA, Novina CD. Lentivirus-delivered stable gene silencing by RNAi in primary cells. Rna (New York, N.Y.). 9: 493-501. PMID 12649500 DOI: 10.1261/Rna.2192803  0.648
2003 Doench JG, Petersen CP, Sharp PA. siRNAs can function as miRNAs. Genes & Development. 17: 438-42. PMID 12600936 DOI: 10.1101/Gad.1064703  0.429
2003 Ge Q, McManus MT, Nguyen T, Shen CH, Sharp PA, Eisen HN, Chen J. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proceedings of the National Academy of Sciences of the United States of America. 100: 2718-23. PMID 12594334 DOI: 10.1073/Pnas.0437841100  0.616
2003 Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee S, Collman RG, Lieberman J, Shankar P, Sharp PA. Erratum: siRNA-directed inhibition of HIV-1 infection Nature Medicine. 9: 1433-1433. DOI: 10.1038/Nm1103-1433A  0.318
2002 McManus MT, Haines BB, Dillon CP, Whitehurst CE, van Parijs L, Chen J, Sharp PA. Small interfering RNA-mediated gene silencing in T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 169: 5754-60. PMID 12421955 DOI: 10.4049/Jimmunol.169.10.5754  0.636
2002 McManus MT, Sharp PA. Gene silencing in mammals by small interfering RNAs. Nature Reviews. Genetics. 3: 737-47. PMID 12360232 DOI: 10.1038/Nrg908  0.63
2002 Fairbrother WG, Yeh RF, Sharp PA, Burge CB. Predictive identification of exonic splicing enhancers in human genes. Science (New York, N.Y.). 297: 1007-13. PMID 12114529 DOI: 10.1126/Science.1073774  0.725
2002 McManus MT, Petersen CP, Haines BB, Chen J, Sharp PA. Gene silencing using micro-RNA designed hairpins. Rna (New York, N.Y.). 8: 842-50. PMID 12088155 DOI: 10.1017/S1355838202024032  0.652
2002 Novina CD, Murray MF, Dykxhoorn DM, Beresford PJ, Riess J, Lee SK, Collman RG, Lieberman J, Shankar P, Sharp PA. siRNA-directed inhibition of HIV-1 infection. Nature Medicine. 8: 681-6. PMID 12042777 DOI: 10.1038/Nm725  0.629
2002 Lee KB, Wang D, Lippard SJ, Sharp PA. Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro. Proceedings of the National Academy of Sciences of the United States of America. 99: 4239-44. PMID 11904382 DOI: 10.1073/Pnas.072068399  0.379
2002 Tantin D, Sharp PA. Mouse lymphoid cell line selected to have high immunoglobulin promoter activity. Molecular and Cellular Biology. 22: 1460-73. PMID 11839812 DOI: 10.1128/MCB.22.5.1460-1473.2002  0.324
2001 Arrow KJ, Axelrod J, Benacerraf B, Berg P, Bishop JM, Bloembergen N, Brown HC, Cibelli J, Cohen S, Cooper LN, Corey EJ, Cronin JW, Curl R, Dulbecco R, Fischer EH, ... ... Sharp PA, et al. Nobel laureates' letter to President Bush. The Washington Post. A02. PMID 12462241  0.48
2001 Sharp PA. RNA interference - 2001 Genes and Development. 15: 485-490. PMID 11238371 DOI: 10.1101/gad.880001  0.382
2001 Tuschl T, Sharp PA, Bartel DP. A ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formation. Rna (New York, N.Y.). 7: 29-43. PMID 11214178 DOI: 10.1017/S1355838201001510  0.72
2001 Kim JB, Sharp PA. Positive Transcription Elongation Factor b Phosphorylates hSPT5 and RNA Polymerase II Carboxyl-terminal Domain Independently of Cyclin-dependent Kinase-activating Kinase Journal of Biological Chemistry. 276: 12317-12323. PMID 11145967 DOI: 10.1074/Jbc.M010908200  0.526
2000 Gilbert SL, Pehrson JR, Sharp PA. XIST RNA associates with specific regions of the inactive X chromatin. The Journal of Biological Chemistry. 275: 36491-4. PMID 11006266 DOI: 10.1074/jbc.C000409200  0.392
2000 Scarr RB, Smith MR, Beddall M, Sharp PA. A novel 50-kilodalton fragment of host cell factor 1 (C1) in G0 cells Molecular and Cellular Biology. 20: 3568-3575. PMID 10779346 DOI: 10.1128/MCB.20.10.3568-3575.2000  0.308
2000 Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell. 101: 25-33. PMID 10778853 DOI: 10.1016/S0092-8674(00)80620-0  0.721
2000 Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA. The SRm160/300 splicing coactivator subunits. Rna (New York, N.Y.). 6: 111-20. PMID 10668804 DOI: 10.1017/S1355838200991982  0.814
1999 Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA. Targeted mRNA degradation by double-stranded RNA in vitro. Genes & Development. 13: 3191-7. PMID 10617568 DOI: 10.1101/Gad.13.24.3191  0.741
1999 Page-McCaw PS, Amonlirdviman K, Sharp PA. PUF60: A novel U2AF65-related splicing activity Rna. 5: 1548-1560. PMID 10606266 DOI: 10.1017/S1355838299991938  0.405
1999 Tang H, Sharp PA. Transcriptional regulation of the murine 3' IgH enhancer by OCT-2 Immunity. 11: 517-526. PMID 10591177 DOI: 10.1016/S1074-7613(00)80127-2  0.345
1999 Kim JB, Yamaguchi Y, Wada T, Handa H, Sharp PA. Tat-SF1 protein associates with RAP30 and human SPT5 proteins. Molecular and Cellular Biology. 19: 5960-8. PMID 10454543 DOI: 10.1128/Mcb.19.9.5960  0.635
1999 Eldridge AG, Li Y, Sharp PA, Blencowe BJ. The SRm160/300 splicing coactivator is required for exon-enhancer function. Proceedings of the National Academy of Sciences of the United States of America. 96: 6125-30. PMID 10339552 DOI: 10.1073/Pnas.96.11.6125  0.744
1999 Mitsui A, Sharp PA. Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain Proceedings of the National Academy of Sciences of the United States of America. 96: 6054-6059. PMID 10339540 DOI: 10.1073/pnas.96.11.6054  0.33
1999 Sharp PA. RNAi and double-strand RNA Genes and Development. 13: 139-141. PMID 9925636 DOI: 10.1101/Gad.13.2.139  0.424
1999 Eldridge A, Issner R, Li Y, Reifenberg E, Sharp PA, Blencowe BJ. Role of the SRm160/300 splicing coactivator in exon-enhancer function Biochemistry and Cell Biology. 77: 393. DOI: 10.1139/O99-903J  0.681
1999 Burge CB, Tuschl T, Sharp PA. 20 Splicing of Precursors to mRNAs by the Spliceosomes Cold Spring Harbor Monograph Archive. 37: 525-560. DOI: 10.1101/087969589.37.525  0.801
1998 Burge CB, Padgett RA, Sharp PA. Evolutionary fates and origins of U12-type introns. Molecular Cell. 2: 773-85. PMID 9885565 DOI: 10.1016/S1097-2765(00)80292-0  0.767
1998 Lim LP, Sharp PA. Alternative splicing of the fibronectin EIIIB exon depends on specific TGCATG repeats Molecular and Cellular Biology. 18: 3900-3906. PMID 9632774 DOI: 10.1128/Mcb.18.7.3900  0.379
1998 Tuschl T, Sharp PA, Bartel DP. Selection in vitro of novel ribozymes from a partially randomized U2 and U6 snRNA library. The Embo Journal. 17: 2637-50. PMID 9564046 DOI: 10.1093/Emboj/17.9.2637  0.676
1998 Blencowe BJ, Issner R, Nickerson JA, Sharp PA. A coactivator of pre-mRNA splicing. Genes & Development. 12: 996-1009. PMID 9531537 DOI: 10.1101/Gad.12.7.996  0.716
1997 Sharp PA, Burge CB. Classification of introns: U2-type or U12-type. Cell. 91: 875-9. PMID 9428511 DOI: 10.1016/S0092-8674(00)80479-1  0.659
1997 Jones G, Sharp PA. Ultraspiracle: An invertebrate nuclear receptor for juvenile hormones Proceedings of the National Academy of Sciences of the United States of America. 94: 13499-13503. PMID 9391054 DOI: 10.1073/pnas.94.25.13499  0.316
1997 Query CC, McCaw PS, Sharp PA. A minimal spliceosomal complex A recognizes the branch site and polypyrimidine tract Molecular and Cellular Biology. 17: 2944-2953. PMID 9111366 DOI: 10.1128/Mcb.17.5.2944  0.38
1997 Kim JS, Kim J, Cepek KL, Sharp PA, Pabo CO. Design of TATA box-binding protein/zinc finger fusions for targeted regulation of gene expression. Proceedings of the National Academy of Sciences of the United States of America. 94: 3616-20. PMID 9108026 DOI: 10.1073/Pnas.94.8.3616  0.364
1997 Shykind BM, Kim J, Stewart L, Champoux JJ, Sharp PA. Topoisomerase I enhances TFIID-TFIIA complex assembly during activation of transcription. Genes & Development. 11: 397-407. PMID 9030691 DOI: 10.1101/Gad.11.3.397  0.76
1997 Macmillan AM, Mccaw PS, Crispino JD, Sharp PA. SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract Proceedings of the National Academy of Sciences of the United States of America. 94: 133-136. PMID 8990173 DOI: 10.1073/Pnas.94.1.133  0.593
1996 Cepek KL, Chasman DI, Sharp PA. Sequence-specific DNA binding of the B-cell-specific coactivator OCA-B. Genes & Development. 10: 2079-88. PMID 8769650 DOI: 10.1101/GAD.10.16.2079  0.336
1996 Crispino JD, Mermoud JE, Lamond AI, Sharp PA. Cis-acting elements distinct from the 5' splice site promote U1-independent pre-mRNA splicing. Rna (New York, N.Y.). 2: 664-73. PMID 8756409  0.736
1996 Harper SE, Qiu Y, Sharp PA. Sin3 corepressor function in Myc-induced transcription and transformation. Proceedings of the National Academy of Sciences of the United States of America. 93: 8536-40. PMID 8710905 DOI: 10.1073/PNAS.93.16.8536  0.343
1996 Mortillaro MJ, Blencowe BJ, Wei X, Nakayasu H, Du L, Warren SL, Sharp PA, Berezney R. A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix. Proceedings of the National Academy of Sciences of the United States of America. 93: 8253-7. PMID 8710856 DOI: 10.1073/Pnas.93.16.8253  0.732
1996 Kim J, Parvin JD, Shykind BM, Sharp PA. A negative cofactor containing Dr1/p19 modulates transcription with TFIIA in a promoter-specific fashion. The Journal of Biological Chemistry. 271: 18405-12. PMID 8702484 DOI: 10.1074/jbc.271.31.18405  0.777
1996 Query CC, Strobel SA, Sharp PA. Three recognition events at the branch-site adenine. The Embo Journal. 15: 1392-402. PMID 8635472 DOI: 10.1002/J.1460-2075.1996.Tb00481.X  0.583
1995 Kristie TM, Pomerantz JL, Twomey TC, Parent SA, Sharp PA. The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides. The Journal of Biological Chemistry. 270: 4387-94. PMID 7876203 DOI: 10.1074/jbc.270.9.4387  0.32
1995 Parvin JD, McCormick RJ, Sharp PA, Fisher DE. Pre-bending of a promoter sequence enhances affinity for the TATA-binding factor Nature. 373: 724-727. PMID 7854460 DOI: 10.1038/373724A0  0.328
1995 Pomerantz JL, Sharp PA, Pabo CO. Structure-based design of transcription factors. Science (New York, N.Y.). 267: 93-6. PMID 7809612 DOI: 10.1126/science.7809612  0.364
1995 Shykind BM, Kim J, Sharp PA. Activation of the TFIID-TFIIA complex with HMG-2. Genes & Development. 9: 1354-65. PMID 7797075 DOI: 10.1101/Gad.9.11.1354  0.77
1995 Mäkelä TP, Parvin JD, Kim J, Huber LJ, Sharp PA, Weinberg RA. A kinase-deficient transcription factor TFIIH is functional in basal and activated transcription. Proceedings of the National Academy of Sciences of the United States of America. 92: 5174-8. PMID 7761469 DOI: 10.1073/Pnas.92.11.5174  0.33
1995 Pomerantz JL, Pabo CO, Sharp PA. Analysis of homeodomain function by structure-based design of a transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 92: 9752-6. PMID 7568211 DOI: 10.1073/pnas.92.21.9752  0.352
1995 Crispino JD, Sharp PA. A U6 snRNA:pre-mRNA interaction can be rate-limiting for U1-independent splicing Genes and Development. 9: 2314-2323. PMID 7557384 DOI: 10.1101/Gad.9.18.2314  0.616
1995 Blencowe BJ, Issner R, Kim J, Mccaw P, Sharp PA. New proteins related to the Ser-Arg family of splicing factors. Rna (New York, N.Y.). 1: 852-65. PMID 7493330  0.667
1995 Zhou Q, Sharp P. Novel mechanism and factor for regulation by HIV-1 Tat. The Embo Journal. 14: 321-328. DOI: 10.1002/j.1460-2075.1995.tb07006.x  0.377
1994 Crispino JD, Blencowe BJ, Sharp PA. Complementation by SR proteins of pre-mRNA splicing reactions depleted of U1 snRNP. Science (New York, N.Y.). 265: 1866-9. PMID 8091213 DOI: 10.1126/Science.8091213  0.76
1994 Parvin JD, Shykind BM, Meyers RE, Kim J, Sharp PA. Multiple sets of basal factors initiate transcription by RNA polymerase II. The Journal of Biological Chemistry. 269: 18414-21. PMID 8034589  0.773
1994 MacMillan AM, Query CC, Allerson CR, Chen S, Verdine GL, Sharp PA. Dynamic association of proteins with the pre-mRNA branch region. Genes & Development. 8: 3008-20. PMID 8001820 DOI: 10.1101/Gad.8.24.3008  0.324
1994 Blencowe BJ, Nickerson JA, Issner R, Penman S, Sharp PA. Association of nuclear matrix antigens with exon-containing splicing complexes. The Journal of Cell Biology. 127: 593-607. PMID 7962048 DOI: 10.1083/Jcb.127.3.593  0.687
1994 Query CC, Moore MJ, Sharp PA. Branch nucleophile selection in pre-mRNA splicing: evidence for the bulged duplex model. Genes & Development. 8: 587-97. PMID 7926752 DOI: 10.1101/Gad.8.5.587  0.59
1994 Pomerantz JL, Sharp PA. Homeodomain determinants of major groove recognition. Biochemistry. 33: 10851-8. PMID 7916208 DOI: 10.1021/bi00202a001  0.338
1994 Sharp PA. Split genes and RNA splicing (nobel lecture) Angewandte Chemie (International Edition in English). 33: 1229-1240. DOI: 10.1016/0092-8674(94)90130-9  0.415
1994 Sharp PA. Diskontinuierliche Gene und das Spleißen von RNA (Nobel-Vortrag) Angewandte Chemie. 106: 1292-1304. DOI: 10.1002/ANGE.19941061207  0.384
1993 Parvin JD, Sharp PA. DNA topology and a minimal set of basal factors for transcription by RNA polymerase II. Cell. 73: 533-40. PMID 8490964 DOI: 10.1016/0092-8674(93)90140-L  0.426
1993 Fisher DE, Parent LA, Sharp PA. High affinity DNA-binding Myc analogs: Recognition by an α helix Cell. 72: 467-476. PMID 8431949 DOI: 10.1016/0092-8674(93)90122-7  0.311
1993 Moore MJ, Sharp PA. Evidence for two active sites in the spliceosome provided by stereochemistry of pre-mRNA splicing. Nature. 365: 364-8. PMID 8397340 DOI: 10.1038/365364A0  0.573
1993 Chasman DI, Flaherty KM, Sharp PA, Kornberg RD. Crystal structure of yeast TATA-binding protein and model for interaction with DNA Proceedings of the National Academy of Sciences of the United States of America. 90: 8174-8178. PMID 8367480 DOI: 10.1073/PNAS.90.17.8174  0.308
1993 Srebrow A, Muro AF, Werbajh S, Sharp PA, Kornblihtt AR. The CRE-binding factor ATF-2 facilitates the occupation of the CCAAT box in the fibronectin gene promoter. Febs Letters. 327: 25-8. PMID 8335091 DOI: 10.1016/0014-5793(93)81031-T  0.373
1993 Kjems J, Sharp PA. The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly. Journal of Virology. 67: 4769-76. PMID 8331728 DOI: 10.1128/Jvi.67.8.4769-4776.1993  0.521
1993 Meyers RE, Sharp PA. TATA-binding protein and associated factors in polymerase II and polymerase III transcription. Molecular and Cellular Biology. 13: 7953-60. PMID 8247010 DOI: 10.1128/MCB.13.12.7953  0.403
1993 Crawford N, Fire A, Samuels M, Sharp PA, Baltimore D. Inhibition of transcription factor activity by poliovirus. Cell. 27: 555-61. PMID 6086108 DOI: 10.1016/0092-8674(81)90397-4  0.603
1993 Moore MJ, Query CC, Sharp PA. 13 Splicing of Precursors to mRNA by the Spliceosome Cold Spring Harbor Monograph Archive. 24: 303-357. DOI: 10.1101/087969380.24.303  0.618
1992 Moore MJ, Sharp PA. Site-specific modification of pre-mRNA: the 2'-hydroxyl groups at the splice sites. Science (New York, N.Y.). 256: 992-7. PMID 1589782 DOI: 10.1126/Science.1589782  0.598
1992 Kjems J, Calnan BJ, Frankel AD, Sharp PA. Specific binding of a basic peptide from HIV-1 Rev. The Embo Journal. 11: 1119-29. PMID 1547776 DOI: 10.1002/J.1460-2075.1992.Tb05152.X  0.575
1992 Parvin JD, Timmers HT, Sharp PA. Promoter specificity of basal transcription factors. Cell. 68: 1135-44. PMID 1547507 DOI: 10.1016/0092-8674(92)90084-P  0.422
1992 Fisher DE, Parent LA, Sharp PA. Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove Proceedings of the National Academy of Sciences of the United States of America. 89: 11779-11783. PMID 1465398 DOI: 10.1073/PNAS.89.24.11779  0.323
1992 Timmers HT, Meyers RE, Sharp PA. Composition of transcription factor B-TFIID. Proceedings of the National Academy of Sciences of the United States of America. 89: 8140-4. PMID 1387711 DOI: 10.1073/PNAS.89.17.8140  0.396
1992 Haber DA, Timmers HT, Pelletier J, Sharp PA, Housman DE. A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells. Proceedings of the National Academy of Sciences of the United States of America. 89: 6010-4. PMID 1321431 DOI: 10.1073/Pnas.89.13.6010  0.329
1992 Buratowski S, Sharp PA. 9 Initiation of Transcription by RNA Polymerase II Cold Spring Harbor Monograph Archive. 227-246. DOI: 10.1101/087969425.22A.227  0.66
1991 Flanagan JR, Murata M, Burke PA, Shirayoshi Y, Appella E, Sharp PA, Ozato K. Negative regulation of the major histocompatibility complex class I promoter in embryonal carcinoma cells Proceedings of the National Academy of Sciences of the United States of America. 88: 3145-3149. PMID 2014233 DOI: 10.1073/Pnas.88.8.3145  0.345
1991 Kjems J, Brown M, Chang DD, Sharp PA. Structural analysis of the interaction between the human immunodeficiency virus Rev protein and the Rev response element. Proceedings of the National Academy of Sciences of the United States of America. 88: 683-7. PMID 1992459 DOI: 10.1073/Pnas.88.3.683  0.644
1991 Timmers HT, Sharp PA. The mammalian TFIID protein is present in two functionally distinct complexes. Genes & Development. 5: 1946-56. PMID 1936986 DOI: 10.1101/GAD.5.11.1946  0.369
1991 Kjems J, Frankel AD, Sharp PA. Specific regulation of mRNA splicing in vitro by a peptide from HIV-1 Rev. Cell. 67: 169-78. PMID 1913815 DOI: 10.1016/0092-8674(91)90580-R  0.563
1991 Gil A, Sharp PA, Jamison SF, Garcia-Blanco MA. Characterization of cDNAs encoding the polypyrimidine tract-binding protein. Genes & Development. 5: 1224-36. PMID 1906035 DOI: 10.1101/Gad.5.7.1224  0.388
1991 Zhang Y, Babin J, Feldhaus AL, Singh H, Sharp PA, Bina M. HTF4: a new human helix-loop-helix protein. Nucleic Acids Research. 19: 4555. PMID 1886779 DOI: 10.1093/Nar/19.16.4555  0.484
1991 Buratowski S, Sopta M, Greenblatt J, Sharp PA. RNA polymerase II-associated proteins are required for a DNA conformation change in the transcription initiation complex. Proceedings of the National Academy of Sciences of the United States of America. 88: 7509-13. PMID 1881889 DOI: 10.1073/Pnas.88.17.7509  0.758
1991 Buckler AJ, Chang DD, Graw SL, Brook JD, Haber DA, Sharp PA, Housman DE. Exon amplification: a strategy to isolate mammalian genes based on RNA splicing. Proceedings of the National Academy of Sciences of the United States of America. 88: 4005-9. PMID 1850845 DOI: 10.1073/Pnas.88.9.4005  0.442
1991 Fisher DE, Carr CS, Parent LA, Sharp PA. TFEB has DNA-binding and oligomerization properties of a unique hefix-loop-helix/leucine-zipper family Genes and Development. 5: 2342-2352. PMID 1748288 DOI: 10.1101/GAD.5.12A.2342  0.306
1991 Marciniak R, Sharp P. HIV-1 Tat protein promotes formation of more-processive elongation complexes. The Embo Journal. 10: 4189-4196. DOI: 10.1002/J.1460-2075.1991.Tb04997.X  0.314
1990 Chang DD, Sharp PA. Regulation by HIV Rev depends upon recognition of splice sites. Cell. 59: 789-95. PMID 2686839 DOI: 10.1016/0092-8674(89)90602-8  0.423
1990 García-Blanco MA, Jamison SF, Sharp PA. Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns. Genes & Development. 3: 1874-86. PMID 2533575 DOI: 10.1101/Gad.3.12A.1874  0.356
1990 Buratowski S, Sharp PA. Transcription initiation complexes and upstream activation with RNA polymerase II lacking the C-terminal domain of the largest subunit. Molecular and Cellular Biology. 10: 5562-4. PMID 2398901 DOI: 10.1128/Mcb.10.10.5562  0.745
1990 Marciniak RA, Garcia-Blanco MA, Sharp PA. Identification and characterization of a HeLa nuclear protein that specifically binds to the trans-activation-response (TAR) element of human immunodeficiency virus. Proceedings of the National Academy of Sciences of the United States of America. 87: 3624-8. PMID 2333305 DOI: 10.1073/Pnas.87.9.3624  0.419
1990 Marciniak RA, Calnan BJ, Frankel AD, Sharp PA. HIV-1 Tat protein trans-activates transcription in vitro. Cell. 63: 791-802. PMID 2225077 DOI: 10.1016/0092-8674(90)90145-5  0.432
1990 Chang DD, Sharp PA. Messenger RNA transport and HIV rev regulation. Science (New York, N.Y.). 249: 614-5. PMID 2143313 DOI: 10.1126/SCIENCE.2143313  0.321
1990 Garcia-Blanco MA, Anderson GJ, Beggs J, Sharp PA. A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein. Proceedings of the National Academy of Sciences of the United States of America. 87: 3082-6. PMID 2139226 DOI: 10.1073/Pnas.87.8.3082  0.337
1990 Carr CS, Sharp PA. A Helix-Loop-Helix protein related to the immunoglobulin E box-binding proteins Molecular and Cellular Biology. 10: 4384-4388. PMID 2115126 DOI: 10.1128/MCB.10.8.4384  0.351
1990 Baldwin AS, LeClair KP, Singh H, Sharp PA. A large protein containing zinc finger domains binds to related sequence elements in the enhancers of the class I major histocompatibility complex and kappa immunoglobulin genes. Molecular and Cellular Biology. 10: 1406-14. PMID 2108316 DOI: 10.1128/mcb.10.4.1406-1414.1990  0.569
1990 Konarska MM, Sharp PA. Structure of RNAs replicated by the DNA-dependent T7 RNA polymerase. Cell. 63: 609-18. PMID 1699668 DOI: 10.1016/0092-8674(90)90456-O  0.675
1989 Buratowski S, Hahn S, Guarente L, Sharp PA. Five intermediate complexes in transcription initiation by RNA polymerase II. Cell. 56: 549-61. PMID 2917366 DOI: 10.1016/0092-8674(89)90578-3  0.754
1989 Manley NR, O'Connell MA, Sharp PA, Hopkins N. Nuclear factors that bind to the enhancer region of nondefective Friend murine leukemia virus. Journal of Virology. 63: 4210-23. PMID 2778872 DOI: 10.1128/Jvi.63.10.4210-4223.1989  0.33
1989 Konarska MM, Sharp PA. Replication of RNA by the DNA-dependent RNA polymerase of phage T7. Cell. 57: 423-31. PMID 2720777 DOI: 10.1016/0092-8674(89)90917-3  0.67
1989 Hahn S, Buratowski S, Sharp PA, Guarente L. Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA. The Embo Journal. 8: 3379-82. PMID 2684641  0.615
1989 Chodosh LA, Buratowski S, Sharp PA. A yeast protein possesses the DNA-binding properties of the adenovirus major late transcription factor. Molecular and Cellular Biology. 9: 820-2. PMID 2651905 DOI: 10.1128/Mcb.9.2.820  0.724
1989 LeBowitz JH, Clerc RG, Brenowitz M, Sharp PA. The Oct-2 protein binds cooperatively to adjacent octamer sites Genes &Amp; Development. 3: 1625-1638. PMID 2612908 DOI: 10.1101/GAD.3.10.1625  0.344
1989 Hahn S, Buratowski S, Sharp PA, Guarente L. Yeast TATA-binding protein TFIID binds to TATA elements with both consensus and nonconsensus DNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 86: 5718-22. PMID 2569738 DOI: 10.1073/Pnas.86.15.5718  0.713
1989 Hahn S, Buratowski S, Sharp PA, Guarente L. Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions. Cell. 58: 1173-81. PMID 2550146 DOI: 10.1016/0092-8674(89)90515-1  0.738
1989 Sedivy JM, Sharp PA. Positive genetic selection for gene disruption in mammalian cells by homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 86: 227-31. PMID 2536156 DOI: 10.1073/Pnas.86.1.227  0.581
1989 Hahn S, Buratowski S, Sharp P, Guarente L. Isolation of the gene encoding the yeast TATA binding TFIID: a gene identical to the SPT15 suppressor of Ty element insertions Trends in Genetics. 5: 393. DOI: 10.1016/0168-9525(89)90187-X  0.684
1989 Kristie T, LeBowitz J, Sharp P. The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein. The Embo Journal. 8: 4229-4238. DOI: 10.1002/j.1460-2075.1989.tb08608.x  0.314
1989 Hahn S, Buratowski S, Sharp P, Guarente L. Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA. The Embo Journal. 8: 3379-3382. DOI: 10.1002/j.1460-2075.1989.tb08501.x  0.699
1988 Skolnik-David H, Moore CL, Sharp PA. Electrophoretic separation of polyadenylation-specific complexes. Genes & Development. 1: 672-82. PMID 3428596 DOI: 10.1101/GAD.1.7.672  0.398
1988 Baldwin AS, Sharp PA. Two transcription factors, NF-kappa B and H2TF1, interact with a single regulatory sequence in the class I major histocompatibility complex promoter. Proceedings of the National Academy of Sciences of the United States of America. 85: 723-7. PMID 3422454 DOI: 10.1073/pnas.85.3.723  0.358
1988 Staudt LM, Clerc RG, Singh H, LeBowitz JH, Sharp PA, Baltimore D. Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif Science. 241: 577-580. PMID 3399892 DOI: 10.1126/Science.3399892  0.672
1988 Watanabe H, Imai T, Sharp PA, Handa H. Identification of two transcription factors that bind to specific elements in the promoter of the adenovirus early-region 4. Molecular and Cellular Biology. 8: 1290-300. PMID 3367909 DOI: 10.1128/Mcb.8.3.1290  0.438
1988 Chodosh LA, Baldwin AS, Carthew RW, Sharp PA. Human CCAAT-binding proteins have heterologous subunits. Cell. 53: 11-24. PMID 3349524 DOI: 10.1016/0092-8674(88)90483-7  0.333
1988 Buratowski S, Hahn S, Sharp PA, Guarente L. Function of a yeast TATA element-binding protein in a mammalian transcription system. Nature. 334: 37-42. PMID 3290687 DOI: 10.1038/334037A0  0.748
1988 Ganguly S, Sharp PA, RajBhandary UL. Saccharomyces cerevisiae SUP53 tRNA gene transcripts are processed by mammalian cell extracts in vitro but are not processed in vivo. Molecular and Cellular Biology. 8: 361-70. PMID 3275875 DOI: 10.1128/Mcb.8.1.361  0.39
1988 Clerc RG, Corcoran LM, LeBowitz JH, Baltimore D, Sharp PA. The B-cell-specific Oct-2 protein contains POU box- and homeo box-type domains Genes &Amp; Development. 2: 1570-1581. PMID 3265124 DOI: 10.1101/GAD.2.12A.1570  0.532
1988 LeBowitz JH, Kobayashi T, Staudt L, Baltimore D, Sharp PA. Octamer-binding proteins from B or HeLa cells stimulate transcription of the immunoglobulin heavy-chain promoter in vitro Genes &Amp; Development. 2: 1227-1237. PMID 3264542 DOI: 10.1101/Gad.2.10.1227  0.497
1988 Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes & Development. 2: 1513-6. PMID 3215510 DOI: 10.1101/Gad.2.12A.1513  0.482
1988 Sharp PA. RNA Splicing and Genes Jama: the Journal of the American Medical Association. 260: 3035-3041. PMID 2972850 DOI: 10.1001/jama.1988.03410200091032  0.47
1988 Konarska MM, Sharp PA. Association of U2, U4, U5, and U6 small nuclear ribonucleoproteins in a spliceosome-type complex in absence of precursor RNA. Proceedings of the National Academy of Sciences of the United States of America. 85: 5459-62. PMID 2969592 DOI: 10.1073/Pnas.85.15.5459  0.637
1988 Singh H, LeBowitz JH, Baldwin AS, Sharp PA. Molecular cloning of an enhancer binding protein: isolation by screening of an expression library with a recognition site DNA. Cell. 52: 415-23. PMID 2964277 DOI: 10.1016/S0092-8674(88)80034-5  0.577
1988 Lamond AI, Konarska MM, Grabowski PJ, Sharp PA. Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein. Proceedings of the National Academy of Sciences of the United States of America. 85: 411-5. PMID 2963332 DOI: 10.1073/Pnas.85.2.411  0.782
1988 Moore CL, Skolnik-David H, Sharp PA. Sedimentation analysis of polyadenylation-specific complexes. Molecular and Cellular Biology. 8: 226-33. PMID 2961980 DOI: 10.1128/MCB.8.1.226  0.42
1988 Weinberger J, Jat PS, Sharp PA. Localization of a repressive sequence contributing to B-cell specificity in the immunoglobulin heavy-chain enhancer. Molecular and Cellular Biology. 8: 988-92. PMID 2832747 DOI: 10.1128/MCB.8.2.988  0.387
1988 Virtanen A, Sharp PA. Processing at immunoglobulin polyadenylation sites in lymphoid cell extracts. The Embo Journal. 7: 1421-1429. DOI: 10.1002/j.1460-2075.1988.tb02959.x  0.318
1987 Hanaka S, Nishigaki T, Sharp PA, Handa H. Regulation of in vitro and in vivo transcription of early-region IV of adenovirus type 5 by multiple cis-acting elements. Molecular and Cellular Biology. 7: 2578-87. PMID 3614200 DOI: 10.1128/Mcb.7.7.2578  0.529
1987 Baldwin AS, Sharp PA. Binding of a nuclear factor to a regulatory sequence in the promoter of the mouse H-2Kb class I major histocompatibility gene. Molecular and Cellular Biology. 7: 305-13. PMID 3561391 DOI: 10.1128/mcb.7.1.305-313.1987  0.37
1987 Carthew RW, Chodosh LA, Sharp PA. The major late transcription factor binds to and activates the mouse metallothionein I promoter. Genes & Development. 1: 973-80. PMID 3428603 DOI: 10.1101/Gad.1.9.973  0.418
1987 Sharp PA, Konarksa MM, Grabowski PJ, Lamond AI, Marciniak R, Seiler SR. Splicing of messenger RNA precursors. Cold Spring Harbor Symposia On Quantitative Biology. 52: 277-85. PMID 3331341 DOI: 10.1101/Sqb.1987.052.01.033  0.691
1987 Sedivy JM, Capone JP, RajBhandary UL, Sharp PA. An inducible mammalian amber suppressor: propagation of a poliovirus mutant. Cell. 50: 379-89. PMID 3038332 DOI: 10.1016/0092-8674(87)90492-2  0.606
1987 Konarska MM, Sharp PA. Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes. Cell. 49: 763-74. PMID 2953438 DOI: 10.1016/0092-8674(87)90614-3  0.628
1987 Lamond AI, Konarska MM, Sharp PA. A mutational analysis of spliceosome assembly: evidence for splice site collaboration during spliceosome formation. Genes & Development. 1: 532-43. PMID 2824284 DOI: 10.1101/Gad.1.6.532  0.771
1986 Choi YD, Grabowski PJ, Sharp PA, Dreyfuss G. Heterogeneous nuclear ribonucleoproteins: role in RNA splicing. Science (New York, N.Y.). 231: 1534-9. PMID 3952495 DOI: 10.1126/Science.3952495  0.346
1986 Chodosh LA, Carthew RW, Sharp PA. A single polypeptide possesses the binding and transcription activities of the adenovirus major late transcription factor. Molecular and Cellular Biology. 6: 4723-33. PMID 3796614 DOI: 10.1128/Mcb.6.12.4723  0.373
1986 Grabowski PJ, Sharp PA. Affinity chromatography of splicing complexes: U2, U5, and U4 + U6 small nuclear ribonucleoprotein particles in the spliceosome. Science (New York, N.Y.). 233: 1294-9. PMID 3638792 DOI: 10.1126/Science.3638792  0.417
1986 Staudt LM, Singh H, Sen R, Wirth T, Sharp PA, Baltimore D. A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature. 323: 640-3. PMID 3095662 DOI: 10.1038/323640A0  0.547
1986 Weinberger J, Baltimore D, Sharp PA. Distinct factors bind to apparently homologous sequences in the immunoglobulin heavy-chain enhancer. Nature. 322: 846-8. PMID 3092107 DOI: 10.1038/322846a0  0.373
1986 Singh H, Sen R, Baltimore D, Sharp PA. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature. 319: 154-8. PMID 3079885 DOI: 10.1038/319154A0  0.582
1986 Capone JP, Sedivy JM, Sharp PA, RajBhandary UL. Introduction of UAG, UAA, and UGA nonsense mutations at a specific site in the Escherichia coli chloramphenicol acetyltransferase gene: use in measurement of amber, ochre, and opal suppression in mammalian cells. Molecular and Cellular Biology. 6: 3059-67. PMID 3023959 DOI: 10.1128/Mcb.6.9.3059  0.606
1986 Jat PS, Cepko CL, Mulligan RC, Sharp PA. Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens. Molecular and Cellular Biology. 6: 1204-17. PMID 3023876 DOI: 10.1128/Mcb.6.4.1204  0.737
1986 Konarska MM, Sharp PA. Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs. Cell. 46: 845-55. PMID 2944598 DOI: 10.1016/0092-8674(86)90066-8  0.638
1986 Padgett RA, Grabowski PJ, Konarska MM, Seiler S, Sharp PA. Splicing of messenger RNA precursors. Annual Review of Biochemistry. 55: 1119-50. PMID 2943217 DOI: 10.1146/Annurev.Bi.55.070186.005351  0.757
1985 Carthew RW, Chodosh LA, Sharp PA. An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter. Cell. 43: 439-48. PMID 4075400 DOI: 10.1016/0092-8674(85)90174-6  0.411
1985 Padgett RA, Konarska MM, Aebi M, Hornig H, Weissmann C, Sharp PA. Nonconsensus branch-site sequences in the in vitro splicing of transcripts of mutant rabbit beta-globin genes. Proceedings of the National Academy of Sciences of the United States of America. 82: 8349-53. PMID 3866228 DOI: 10.1073/Pnas.82.24.8349  0.767
1985 Konarska MM, Padgett RA, Sharp PA. Trans splicing of mRNA precursors in vitro. Cell. 42: 165-71. PMID 3848348 DOI: 10.1016/S0092-8674(85)80112-4  0.773
1985 Berkner KL, Sharp PA. Effect of the tripartite leader on synthesis of a non-viral protein in an adenovirus 5 recombinant. Nucleic Acids Research. 13: 841-57. PMID 3839074 DOI: 10.1093/NAR/13.3.841  0.4
1985 Grabowski PJ, Seiler SR, Sharp PA. A multicomponent complex is involved in the splicing of messenger RNA precursors. Cell. 42: 345-53. PMID 3160482 DOI: 10.1016/S0092-8674(85)80130-6  0.424
1985 Capone JP, Sharp PA, RajBhandary UL. Amber, ochre and opal suppressor tRNA genes derived from a human serine tRNA gene. The Embo Journal. 4: 213-21. PMID 2990894 DOI: 10.1002/J.1460-2075.1985.Tb02338.X  0.339
1985 Kingston RE, Baldwin AS, Sharp PA. Transcription control by oncogenes. Cell. 41: 3-5. PMID 2986847 DOI: 10.1016/0092-8674(85)90049-2  0.55
1985 Konarska MM, Grabowski PJ, Padgett RA, Sharp PA. Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors. Nature. 313: 552-7. PMID 2578627 DOI: 10.1038/313552A0  0.766
1985 Sharp PA. On the origin of RNA splicing and introns Cell. 42: 397-400. PMID 2411416 DOI: 10.1016/0092-8674(85)90092-3  0.407
1985 Moore CL, Sharp PA. Accurate cleavage and polyadenylation of exogenous RNA substrate. Cell. 41: 845-55. PMID 2408761 DOI: 10.1016/S0092-8674(85)80065-9  0.415
1985 Padgett RA, Grabowski PJ, Konarska MM, Sharp PA. Splicing messenger RNA precursors: branch sites and lariat RNAs Trends in Biochemical Sciences. 10: 154-157. DOI: 10.1016/0968-0004(85)90156-2  0.66
1984 Grabowski PJ, Padgett RA, Sharp PA. Messenger RNA splicing in vitro: an excised intervening sequence and a potential intermediate. Cell. 37: 415-27. PMID 6722880 DOI: 10.1016/0092-8674(84)90372-6  0.669
1984 Handa H, Sharp PA. Requirement for distal upstream sequences for maximal transcription in vitro of early region IV of adenovirus. Molecular and Cellular Biology. 4: 791-8. PMID 6717442 DOI: 10.1128/Mcb.4.4.791  0.529
1984 Hardy SF, Grabowski PJ, Padgett RA, Sharp PA. Cofactor requirements of splicing of purified messenger RNA precursors. Nature. 308: 375-7. PMID 6709044 DOI: 10.1038/308375A0  0.672
1984 Konarska MM, Padgett RA, Sharp PA. Recognition of cap structure in splicing in vitro of mRNA precursors. Cell. 38: 731-6. PMID 6567484 DOI: 10.1016/0092-8674(84)90268-X  0.77
1984 Kingston RE, Baldwin AS, Sharp PA. Regulation of heat shock protein 70 gene expression by c-myc. Nature. 312: 280-2. PMID 6438521 DOI: 10.1038/312280A0  0.557
1984 Moore CL, Sharp PA. Site-specific polyadenylation in a cell-free reaction. Cell. 36: 581-91. PMID 6230155 DOI: 10.1016/0092-8674(84)90337-4  0.427
1984 Padgett RA, Konarska MM, Grabowski PJ, Hardy SF, Sharp PA. Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors. Science (New York, N.Y.). 225: 898-903. PMID 6206566 DOI: 10.1126/Science.6206566  0.77
1984 Berkner KL, Sharp PA. Expression of dihydrofolate reductase, and of the adjacent EIb region, in an Ad5-dihydrofolate reductase recombinant virus. Nucleic Acids Research. 12: 1925-41. PMID 6199745 DOI: 10.1093/NAR/12.4.1925  0.373
1984 Laski FA, Belagaje R, Hudziak RM, Capecchi MR, Norton GP, Palese P, RajBhandary UL, Sharp PA. Synthesis of an ochre suppressor tRNA gene and expression in mammalian cells. The Embo Journal. 3: 2445-52. PMID 6096120 DOI: 10.1002/J.1460-2075.1984.Tb02154.X  0.563
1984 Kingston RE, Kaufman RJ, Sharp PA. Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity. Molecular and Cellular Biology. 4: 1970-7. PMID 6095034 DOI: 10.1128/Mcb.4.10.1970  0.68
1983 Kaufman RJ, Sharp PA, Latt SA. Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences. Molecular and Cellular Biology. 3: 699-711. PMID 6855772 DOI: 10.1128/Mcb.3.4.699  0.471
1983 Cepko CL, Sharp PA. Analysis of Ad5 hexon and 100K ts mutants using conformation-specific monoclonal antibodies. Virology. 129: 137-54. PMID 6612996 DOI: 10.1016/0042-6822(83)90402-6  0.639
1983 Padgett RA, Hardy SF, Sharp PA. Splicing of adenovirus RNA in a cell-free transcription system. Proceedings of the National Academy of Sciences of the United States of America. 80: 5230-4. PMID 6577417 DOI: 10.1073/Pnas.80.17.5230  0.765
1983 Laski FA, Fire AZ, RajBhandary UL, Sharp PA. Characterization of tRNA precursor splicing in mammalian extracts. The Journal of Biological Chemistry. 258: 11974-80. PMID 6413507  0.569
1983 Cepko CL, Sharp PA. Aberrant distribution of human adenovirus type 2 late proteins in monkey kidney cells. Journal of Virology. 46: 302-6. PMID 6402607 DOI: 10.1128/Jvi.46.1.302-306.1983  0.625
1983 Cepko CL, Whetstone CA, Sharp PA. Adenovirus hexon monoclonal antibody that is group specific and potentially useful as a diagnostic reagent. Journal of Clinical Microbiology. 17: 360-4. PMID 6339552 DOI: 10.1128/Jcm.17.2.360-364.1983  0.608
1983 Hansen U, Sharp PA. Sequences controlling in vitro transcription of SV40 promoters Embo Journal. 2: 2293-2303. PMID 6321158 DOI: 10.1002/J.1460-2075.1983.Tb01737.X  0.406
1983 Summers WP, Summers WC, Laski FA, RajBhandary UL, Sharp PA. Functional suppression in mammalian cells of nonsense mutations in the herpes simplex virus thymidine kinase gene by suppressor tRNA genes. Journal of Virology. 47: 376-9. PMID 6312072 DOI: 10.1128/Jvi.47.2.376-379.1983  0.3
1983 Berkner KL, Sharp PA. Generation of adenovirus by transfection of plasmids. Nucleic Acids Research. 11: 6003-20. PMID 6310523 DOI: 10.1093/NAR/11.17.6003  0.315
1983 Young JF, Capecchi M, Laski FA, RajBhandary UL, Sharp PA, Palese P. Measurement of suppressor transfer RNA activity. Science (New York, N.Y.). 221: 873-5. PMID 6308765 DOI: 10.1126/Science.6308765  0.589
1983 Handa H, Kingston RE, Sharp PA. Inhibition of adenovirus early region IV transcription in vitro by a purified viral DNA binding protein. Nature. 302: 545-7. PMID 6300688 DOI: 10.1038/302545A0  0.658
1983 Padgett RA, Mount SM, Steitz JA, Sharp PA. Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein. Cell. 35: 101-7. PMID 6194895 DOI: 10.1016/0092-8674(83)90212-X  0.782
1983 Manley JL, Fire A, Samuels M, Sharp PA. In vitro transcription: whole-cell extract. Methods in Enzymology. 101: 568-82. PMID 6193397 DOI: 10.1016/0076-6879(83)01038-1  0.614
1983 Horowitz M, Cepko CL, Sharp PA. Expression of chimeric genes in the early region of SV40. Journal of Molecular and Applied Genetics. 2: 147-59. PMID 6192195  0.679
1983 Sharp PA. Conversion of RNA to DNA in mammals: Alu-like elements and pseudogenes Nature. 301: 471-472. PMID 6185852 DOI: 10.1038/301471a0  0.385
1983 Kaufman RJ, Sharp PA. Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes. Molecular and Cellular Biology. 3: 1598-608. PMID 6138708 DOI: 10.1128/Mcb.3.9.1598  0.518
1982 Cepko CL, Sharp PA. Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell. 31: 407-15. PMID 7159928 DOI: 10.1016/0092-8674(82)90134-9  0.633
1982 Lemischka I, Sharp PA. The sequences of an expressed rat alpha-tubulin gene and a pseudogene with an inserted repetitive element. Nature. 300: 330-5. PMID 6927856 DOI: 10.1038/300330a0  0.707
1982 Hudziak RM, Laski FA, RajBhandary UL, Sharp PA, Capecchi MR. Establishment of mammalian cell lines containing multiple nonsense mutations and functional suppressor tRNA genes. Cell. 31: 137-46. PMID 6760983 DOI: 10.1016/0092-8674(82)90413-5  0.553
1982 Laski FA, Belagaje R, RajBhandary UL, Sharp PA. An amber suppressor tRNA gene derived by site-specific mutagenesis: cloning and function in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 79: 5813-7. PMID 6310546 DOI: 10.1073/Pnas.79.19.5813  0.394
1982 Kaufman RJ, Sharp PA. Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene. Journal of Molecular Biology. 159: 601-21. PMID 6292436 DOI: 10.1016/0022-2836(82)90103-6  0.511
1982 Manley JL, Sharp PA, Gefter ML. Rna synthesis in isolated nuclei processing of adenovirus serotype 2 late messenger rna precursors. Journal of Molecular Biology. 159: 581-99. PMID 6183434 DOI: 10.1016/0022-2836(82)90102-4  0.422
1982 Kaufman RJ, Sharp PA. Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression. Molecular and Cellular Biology. 2: 1304-19. PMID 6131378 DOI: 10.1128/Mcb.2.11.1304  0.573
1981 Lemischka IR, Farmer S, Racaniello VR, Sharp PA. Nucleotide sequence and evolution of a mammalian α-Tubulin messenger RNA Journal of Molecular Biology. 151: 101-120. PMID 7328649 DOI: 10.1016/0022-2836(81)90223-0  0.705
1981 Fire A, Baker CC, Manley JL, Ziff EB, Sharp PA. In vitro transcription of adenovirus. Journal of Virology. 40: 703-19. PMID 7321101 DOI: 10.1128/Jvi.40.3.703-719.1981  0.592
1981 Sharp PA. Speculations on RNA splicing Cell. 23: 643-646. PMID 7226224 DOI: 10.1016/0092-8674(81)90425-6  0.397
1981 Cepko CL, Changelian PS, Sharp PA. Immunoprecipitation with two-dimensional pools as a hybridoma screening technique: production and characterization of monoclonal antibodies against adenovirus 2 proteins. Virology. 110: 385-401. PMID 7222481 DOI: 10.1016/0042-6822(81)90069-6  0.629
1981 Sharp PA, Manley J, Fire A, Gefter M. Regulation of adenovirus mRNA synthesis. Annals of the New York Academy of Sciences. 354: 1-15. PMID 7013617 DOI: 10.1111/J.1749-6632.1980.Tb27954.X  0.652
1981 Ricciardi RP, Jones RL, Cepko CL, Sharp PA, Roberts BE. Expression of early adenovirus genes requires a viral encoded acidic polypeptide. Proceedings of the National Academy of Sciences of the United States of America. 78: 6121-5. PMID 6947217 DOI: 10.1073/pnas.78.10.6121  0.703
1981 Cepko CL, Hansen U, Handa H, Sharp PA. Sequential transcription-translation of simian virus 40 by using mammalian cell extracts. Molecular and Cellular Biology. 1: 919-31. PMID 6287212 DOI: 10.1128/Mcb.1.10.919  0.746
1981 Chu G, Sharp PA. A gene chimaera of SV40 and mouse beta-globin is transcribed and properly spliced. Nature. 289: 378-82. PMID 6258077 DOI: 10.1038/289378A0  0.35
1981 Handa H, Kaufman RJ, Manley J, Gefter M, Sharp PA. Transcription of Simian virus 40 DNA in a HeLa whole cell extract. The Journal of Biological Chemistry. 256: 478-82. PMID 6256354  0.629
1981 Hansen U, Tenen DG, Livingston DM, Sharp PA. T antigen repression of SV40 early transcription from two promoters Cell. 27: 603-612. PMID 6101224 DOI: 10.1016/0092-8674(81)90402-5  0.543
1980 Manley JL, Fire A, Cano A, Sharp PA, Gefter ML. DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract. Proceedings of the National Academy of Sciences of the United States of America. 77: 3855-9. PMID 6933441 DOI: 10.1073/Pnas.77.7.3855  0.661
1980 Donoghue DJ, Goldfarb MP, Sharp PA, Weinberg RA. Organization of murine sarcoma virus genomes. Cold Spring Harbor Symposia On Quantitative Biology. 44: 721-6. PMID 6253206 DOI: 10.1101/Sqb.1980.044.01.077  0.496
1980 Handa H, Sharp PA. Expression of early and late simian virus 40 transcripts in the absence of protein synthesis. Journal of Virology. 34: 592-7. PMID 6247498 DOI: 10.1128/Jvi.34.3.592-597.1980  0.488
1980 Sharp PA, Berk AJ, Berget SM. [69] Transcription maps of adenovirus Methods in Enzymology. 65: 750-768. PMID 6246372 DOI: 10.1016/S0076-6879(80)65071-X  0.617
1979 Berk AJ, Lee F, Harrison T, Williams J, Sharp PA. Phenotypes of adenovirus-5 host-range mutants for early mRNA synthesis Symposia On Quantitative Biology. 44: 429-436. PMID 6933039 DOI: 10.1101/Sqb.1980.044.01.046  0.564
1979 Donoghue DJ, Sharp PA, Weinberg RA. An MSV-specific subgenomic mRNA in MSV-transformed G8-124 cells. Cell. 17: 53-63. PMID 556552 DOI: 10.1016/0092-8674(79)90294-0  0.628
1979 Manley JL, Sharp PA, Gefter ML. RNA synthesis in isolated nuclei: identification and comparison of adenovirus 2 encoded transcripts synthesized in vitro and vivo. Journal of Molecular Biology. 135: 171-97. PMID 529286 DOI: 10.1016/0022-2836(79)90346-2  0.45
1979 Berk AJ, Lee F, Harrison T, Williams J, Sharp PA. Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs Cell. 17: 935-944. PMID 487437 DOI: 10.1016/0092-8674(79)90333-7  0.624
1979 Berget SM, Sharp PA. Structure of late adenovirus 2 heterogeneous nuclear RNA. Journal of Molecular Biology. 129: 547-65. PMID 480350 DOI: 10.1016/0022-2836(79)90468-6  0.45
1979 Kronenberg HM, McDevitt BE, Majzoub JA, Nathans J, Sharp PA, Potts JT, Rich A. Cloning and nucleotide sequence of DNA coding for bovine preproparathyroid hormone. Proceedings of the National Academy of Sciences of the United States of America. 76: 4981-5. PMID 388425 DOI: 10.1073/pnas.76.10.4981  0.327
1979 Manley JL, Sharp PA, Gefter ML. RNA synthesis in isolated nuclei: in vitro initiation of adenovirus 2 major late mRNA precursor. Proceedings of the National Academy of Sciences of the United States of America. 76: 160-4. PMID 284328 DOI: 10.1073/Pnas.76.1.160  0.44
1979 Donoghue DJ, Sharp PA, Weinberg RA. Comparative study of different isolates of murine sarcoma virus. Journal of Virology. 32: 1015-27. PMID 229256 DOI: 10.1128/Jvi.32.3.1015-1027.1979  0.568
1979 Donoghue DJ, Sharp PA, Weinberg RA. Comparative study of different isolates of murine sarcoma virus. Journal of Virology. 32: 1015-1027. DOI: 10.1128/jvi.32.3.1015-1027.1979  0.431
1978 Berk AJ, Sharp PA. Structure of the adenovirus 2 early mRNAs Cell. 14: 695-711. PMID 688389 DOI: 10.1016/0092-8674(78)90252-0  0.646
1978 Donoghue DJ, Sharp PA. Construction of a hybrid bacteriophage-plasmid recombinant DNA vector. Journal of Bacteriology. 136: 1192-6. PMID 363694 DOI: 10.1128/Jb.136.3.1192-1196.1978  0.533
1978 Donoghue DJ, Sharp PA. Replication of colicin E1 plasmid DNA in vivo requires no plasmid-encoded proteins. Journal of Bacteriology. 133: 1287-94. PMID 346567 DOI: 10.1128/Jb.133.3.1287-1294.1978  0.529
1978 Donoghue DJ, Rothenberg E, Hopkins N, Baltimore D, Sharp PA. Heteroduplex analysis of the nonhomology region between Moloney MuLV and the dual host range derivative HIX virus. Cell. 14: 959-70. PMID 210960 DOI: 10.1016/0092-8674(78)90350-1  0.605
1978 Berk AJ, Sharp PA. Spliced early mRNAs of simian virus 40 Proceedings of the National Academy of Sciences of the United States of America. 75: 1274-1278. PMID 206891 DOI: 10.1073/Pnas.75.3.1274  0.648
1977 Flint SJ, Berget SM, Sharp PA. Characterization of single-stranded viral DNA sequences present during replication of adenovirus types 2 and 5. Cell. 9: 559-71. PMID 1009576 DOI: 10.1016/0092-8674(76)90038-6  0.302
1977 Berk AJ, Sharp PA. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids Cell. 12: 721-732. PMID 922889 DOI: 10.1016/0092-8674(77)90272-0  0.624
1977 Berk AJ, Sharp PA. Ultraviolet mapping of the adenovirus 2 early promoters Cell. 12: 45-55. PMID 902320 DOI: 10.1016/0092-8674(77)90184-2  0.622
1977 Donoghue DJ, Sharp PA. An improved bacteriophage lambda vector: construction of model recombinants coding for kanamycin resistance. Gene. 1: 209-27. PMID 338417 DOI: 10.1016/0378-1119(77)90046-4  0.536
1977 Berget SM, Berk AJ, Harrison T, Sharp PA. Spliced segments at the 5' termini of adenovirus-2 late mRNA: A role for heterogeneous nuclear RNA in mammalian cells Cold Spring Harbor Symposia On Quantitative Biology. 42: 523-529. PMID 277361 DOI: 10.1101/Sqb.1978.042.01.055  0.646
1977 Berget SM, Moore C, Sharp PA. Spliced segments at the 5' terminus of adenovirus 2 late mRNA. Proceedings of the National Academy of Sciences of the United States of America. 74: 3171-5. PMID 269380 DOI: 10.1073/PNAS.74.8.3171  0.416
1977 Flint SJ, Sharp PA. Adenovirus transcription. V. Quantitation of viral RNA sequences in adenovirus 2-infected and transformed cells. Journal of Molecular Biology. 106: 749-74. PMID 185395 DOI: 10.1016/0022-2836(76)90263-1  0.432
1976 Flint SJ, Sambrook J, Williams JF, Sharp PA. Viral nucleic acid sequences in transformed cells. IV. A study of the sequences of adenovirus 5 DNA and RNA in four lines of Adenovirus 5-transformed rodent cells using specific fragments of the viral genome Virology. 72: 456-470. PMID 986101 DOI: 10.1016/0042-6822(76)90174-4  0.357
1976 Berget SM, Flint SJ, Williams JF, Sharp PA. Adenovirus transcription. IV. Synthesis of viral-specific RNA in human cells infected with temperature-sensitive mutants of adenovirus 5. Journal of Virology. 19: 879-89. PMID 972434 DOI: 10.1128/JVI.19.3.879-889.1976  0.414
1976 Flint SJ, Berget SM, Sharp PA. Adenovirus transcription. III. Mapping of viral RNA sequences in cells productively infected by adenovirus type 5. Virology. 72: 443-55. PMID 948869 DOI: 10.1016/0042-6822(76)90173-2  0.396
1975 Flint SJ, Gallimore PH, Sharp PA. Comparison of viral RNA sequences in adenovirus 2-transformed and lytically infected cells. Journal of Molecular Biology. 96: 47-68. PMID 1099215 DOI: 10.1016/0022-2836(75)90181-3  0.415
1975 Sharp PA, Gallimore PH, Flint SJ. Mapping of adenovirus 2 RNA sequences in lytically infected cells and transformed cell lines. Cold Spring Harbor Symposia On Quantitative Biology. 457-74. PMID 1057474 DOI: 10.1101/SQB.1974.039.01.058  0.419
1975 Flint SJ, Wewerka-Lutz Y, Levine AS, Sambrook J, Sharp PA. Adenovirus transcription. II. RNA sequences complementary to simian virus 40 and adenovirus 2DNA in Ad2 +ND 1 and Ad2 +ND 3 infected cells Journal of Virology. 16: 662-673. PMID 169392 DOI: 10.1128/Jvi.16.3.662-673.1975  0.36
1974 Botchan M, Ozanne B, Sugden B, Sharp PA, Sambrook J. Viral DNA in transformed cells. III. The amounts of different regions of the SV40 genome present in a line of transformed mouse cells Proceedings of the National Academy of Sciences of the United States of America. 71: 4183-4187. PMID 4372611 DOI: 10.1073/Pnas.71.10.4183  0.697
1974 Botchan M, McKenna G, Sharp PA. Cleavage of mouse DNA by a restriction enzyme as a clue to the arrangement of genes. Cold Spring Harbor Symposia On Quantitative Biology. 38: 383-95. PMID 4364785 DOI: 10.1101/SQB.1974.038.01.041  0.567
1974 Sambrook J, Botchan M, Gallimore P, Ozanne B, Pettersson U, Williams J, Sharp PA. Viral DNA sequences in cells transformed by simian virus 40, adenovirus type 2 and adenovirus type 5 Symposia On Quantitative Biology. 39: 615-632. PMID 169095 DOI: 10.1101/Sqb.1974.039.01.075  0.578
1973 Sharp PA, Cohen SN, Davidson N. Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors. Journal of Molecular Biology. 75: 235-55. PMID 4580676 DOI: 10.1016/0022-2836(73)90018-1  0.455
1973 Sharp PA, Sugden B, Sambrook J. Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis Biochemistry. 12: 3055-3063. PMID 4354250 DOI: 10.1021/Bi00740A018  0.549
1973 Ozanne B, Sharp PA, Sambrook J. Transcription of simian virus 40. II. Hybridization of RNA extracted from different lines of transformed cells to the separated strands of simian virus 40 DNA. Journal of Virology. 12: 90-8. PMID 4353503 DOI: 10.1128/Jvi.12.1.90-98.1973  0.356
1973 Sambrook J, Sugden B, Keller W, Sharp PA. Transcription of simian virus 40. III. Mapping of 'early' and 'late' species of RNA Proceedings of the National Academy of Sciences of the United States of America. 70: 3711-3715. PMID 4129925 DOI: 10.1073/Pnas.70.12.3711  0.612
1972 Sharp PA, Hsu M, Davidson N. Note on the structure of prophage lambda. Journal of Molecular Biology. 71: 499-501. PMID 4635993 DOI: 10.1016/0022-2836(72)90364-6  0.432
1972 Sharp PA, Hsu MT, Otsubo E, Davidson N. Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. I. Structure of F-prime factors. Journal of Molecular Biology. 71: 471-97. PMID 4564488 DOI: 10.1016/0022-2836(72)90363-4  0.419
1972 Kim J, Sharp PA, Davidson N. Electron microscope studies of heteroduplex DNA from a deletion mutant of bacteriophage phiX-174. Proceedings of the National Academy of Sciences of the United States of America. 69: 1948-52. PMID 4505672 DOI: 10.1073/Pnas.69.7.1948  0.471
1972 Sambrook J, Sharp PA, Keller W. Transcription of Simian virus 40. I. Separation of the strands of SV40 DNA and hybridization of the separated strands to RNA extracted from lytically infected and transformed cells. Journal of Molecular Biology. 70: 57-71. PMID 4342195 DOI: 10.1016/0022-2836(72)90163-5  0.356
1972 Tai HT, Smith CA, Sharp PA, Vinograd J. Sequence heterogeneity in closed simian virus 40 deoxyribonucleic acid. Journal of Virology. 9: 317-25. PMID 4335521 DOI: 10.1128/Jvi.9.2.317-325.1972  0.309
1970 Sharp PA, Bloomfield VA. Binding of proflavine and ethidium bromide to two forms of T2 bacteriophage with different sedimentation coefficients. Biochemical and Biophysical Research Communications. 39: 407-13. PMID 5421943 DOI: 10.1016/0006-291X(70)90592-9  0.521
1968 Sharp P, Bloomfield VA. Light scattering from wormlike chains with excluded volume effects Biopolymers - Peptide Science Section. 6: 1201-1211. PMID 5663414 DOI: 10.1002/Bip.1968.360060814  0.496
1968 Sharp P, Bloomfield VA. Intrinsic viscosity of wormlike chains with excluded-volume effects. The Journal of Chemical Physics. 48: 2149-55. PMID 5651080 DOI: 10.1063/1.1669405  0.482
1968 Sharp PA, Bloomfield VA. Light Scattering and Hydrodynamic Properties of Polymer Chains with Excluded Volume Effects The Journal of Chemical Physics. 49: 4564-4566. DOI: 10.1063/1.1669913  0.487
1968 Bloomfield VA, Sharp PA. Variation in Intrinsic Viscosity ø Parameter with Chain Topology, Hydrodynamic Interaction, and Excluded Volume Macromolecules. 1: 380-384. DOI: 10.1021/MA60005A002  0.471
1968 Bloomfield VA, Sharp PA. Variation in intrinsic viscosity φ parameter with chain topology, hydrodynamic interaction, and excluded volume Macromolecules. 1: 380-384.  0.409
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