Mary A. Stepp - Publications

Affiliations: 
Anatomy and Cell Biology The George Washington University, Washington, DC, United States 
Area:
Biomedical Engineering, Cell Biology, Histology of the eye
Website:
https://apps.smhs.gwu.edu/smhs/facultydirectory/profile.cfm?empName=Mary%20Ann%20Stepp&FacID=2049230279

74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Le PM, Pal-Ghosh S, Menko AS, Stepp MA. Immune Cells Localize to Sites of Corneal Erosions in C57BL/6 Mice. Biomolecules. 13. PMID 37509096 DOI: 10.3390/biom13071059  0.318
2022 Pal-Ghosh S, Karpinski BA, Datta Majumdar H, Ghosh T, Julie T, Stephen RB, Andrew PS, Maria IM, Kaitlin KS, S de Paiva C, Jeremias GG, Stepp MA. Molecular mechanisms regulating wound repair: Evidence for paracrine signaling from corneal epithelial cells to fibroblasts and immune cells following transient epithelial cell treatment with Mitomycin C. Experimental Eye Research. 109353. PMID 36539051 DOI: 10.1016/j.exer.2022.109353  0.368
2021 Wang X, Chung L, Hooks J, Maestas DR, Lebid A, Andorko JI, Huleihel L, Chin AF, Wolf M, Remlinger NT, Stepp MA, Housseau F, Elisseeff JH. Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing. Science Advances. 7. PMID 33863719 DOI: 10.1126/sciadv.abe2635  0.344
2020 Pal-Ghosh S, Tadvalkar G, Karpinski BA, Stepp MA. Diurnal Control of Sensory Axon Growth and Shedding in the Mouse Cornea. Investigative Ophthalmology & Visual Science. 61: 1. PMID 32870244 DOI: 10.1167/Iovs.61.11.1  0.328
2020 Tadvalkar G, Pal-Ghosh S, Pajoohesh-Ganji A, Stepp MA. The impact of euthanasia and enucleation on mouse corneal epithelial axon density and nerve terminal morphology. The Ocular Surface. PMID 32798735 DOI: 10.1016/J.Jtos.2020.07.021  0.671
2020 McKay TB, Schlötzer-Schrehardt U, Pal-Ghosh S, Stepp MA. Integrin: Basement membrane adhesion by corneal epithelial and endothelial cells. Experimental Eye Research. 108138. PMID 32712184 DOI: 10.1016/J.Exer.2020.108138  0.43
2020 Stepp MA, Pal-Ghosh S, Tadvalkar G, de Paiva CS. Parity Attenuates Intraepithelial Corneal Sensory Nerve Loss in Female Mice. International Journal of Molecular Sciences. 21. PMID 32708332 DOI: 10.3390/Ijms21145172  0.341
2020 DeDreu J, Bowen CJ, Logan CM, Pal-Ghosh S, Parlanti P, Stepp MA, Menko AS. An immune response to the avascular lens following wounding of the cornea involves ciliary zonule fibrils. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32452112 DOI: 10.1096/Fj.202000289R  0.395
2020 Parlanti P, Pal-Ghosh S, Williams A, Tadvalkar G, Popratiloff A, Stepp MA. Axonal debris accumulates in corneal epithelial cells after intraepithelial corneal nerves are damaged: A focused Ion Beam Scanning Electron Microscopy (FIB-SEM) study. Experimental Eye Research. 107998. PMID 32209319 DOI: 10.1016/J.Exer.2020.107998  0.404
2019 Pal-Ghosh S, Tadvalkar G, Lieberman VR, Guo X, Zieske JD, Hutcheon A, Stepp MA. Transient Mitomycin C-treatment of human corneal epithelial cells and fibroblasts alters cell migration, cytokine secretion, and matrix accumulation. Scientific Reports. 9: 13905. PMID 31554858 DOI: 10.1038/S41598-019-50307-9  0.477
2019 Menko AS, Walker JL, Stepp MA. Fibrosis: Shared lessons from the lens and cornea. Anatomical Record (Hoboken, N.J. : 2007). PMID 30768772 DOI: 10.1002/Ar.24088  0.39
2018 Pietraszkiewicz A, Hampton C, Caplash S, Lei L, Cepetanaki Y, Tadvalkar G, Pal-Ghosh S, Stepp MA, Bargagna-Mohan P, Mohan R. Desmin deficiency is not sufficient to prevent corneal fibrosis. Experimental Eye Research. 180: 155-163. PMID 30590024 DOI: 10.1016/J.Exer.2018.12.019  0.412
2018 Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams AR, Pflugfelder SC, de Paiva CS. Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome. International Journal of Molecular Sciences. 19. PMID 30513621 DOI: 10.3390/Ijms19123821  0.374
2018 Stepp MA, Pal-Ghosh S, Tadvalkar G, Li L, Brooks SR, Morasso MI. Molecular basis of Mitomycin C enhanced corneal sensory nerve repair after debridement wounding. Scientific Reports. 8: 16960. PMID 30446696 DOI: 10.1038/S41598-018-35090-3  0.391
2018 Gjika E, Pal-Ghosh S, Tang A, Kirschner M, Tadvalkar G, Canady J, Stepp MA, Keidar M. Adaptation of operational parameters of cold atmospheric plasma for in vitro treatment of cancer cells. Acs Applied Materials & Interfaces. PMID 29473408 DOI: 10.1021/Acsami.7B18653  0.302
2018 Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams A, Pflugfelder SC, de Paiva CS. Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Experimental Eye Research. PMID 29407221 DOI: 10.1016/J.Exer.2018.01.024  0.371
2018 Kaplan N, Ventrella R, Peng H, Pal-Ghosh S, Arvanitis C, Rappoport JZ, Mitchell BJ, Stepp MA, Lavker RM, Getsios S. EphA2/Ephrin-A1 Mediate Corneal Epithelial Cell Compartmentalization via ADAM10 Regulation of EGFR Signaling. Investigative Ophthalmology & Visual Science. 59: 393-406. PMID 29351356 DOI: 10.1167/Iovs.17-22941  0.341
2018 Gjika E, Pal-Ghosh S, Lin L, Tadvalkar G, Chen Z, Young C, Canady J, Sherman J, Stepp MA, Keidar M. Adaptation Of Operational Parameters Of Cold Atmospheric Plasma And Their Role In Cancer Therapy Clinical Plasma Medicine. 9: 16-17. DOI: 10.1016/J.Cpme.2017.12.026  0.328
2017 Pal-Ghosh S, Tadvalkar G, Stepp MA. Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. Investigative Ophthalmology & Visual Science. 58: 4959-4975. PMID 28973369 DOI: 10.1167/Iovs.17-21531  0.309
2016 Stepp MA, Tadvalkar G, Hakh R, Pal-Ghosh S. Corneal epithelial cells function as surrogate Schwann cells for their sensory nerves. Glia. 65: 851-863. PMID 27878997 DOI: 10.1002/Glia.23102  0.43
2016 Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Stepp MA. K14 + Compound niches are present on the mouse cornea early after birth and expand after debridement wounds. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 245: 132-43. PMID 26515029 DOI: 10.1002/Dvdy.24365  0.738
2015 Pal-Ghosh S, Pajoohesh-Ganji A, Tadvalkar G, Kyne BM, Guo X, Zieske JD, Stepp MA. Topical Mitomycin-C enhances subbasal nerve regeneration and reduces erosion frequency in the debridement wounded mouse cornea. Experimental Eye Research. PMID 26332224 DOI: 10.1016/J.Exer.2015.08.023  0.759
2015 Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Kyne BM, Saban DR, Stepp MA. Partial denervation of sub-basal axons persists following debridement wounds to the mouse cornea. Laboratory Investigation; a Journal of Technical Methods and Pathology. 95: 1305-18. PMID 26280222 DOI: 10.1038/Labinvest.2015.113  0.713
2015 Stepp MA, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Syndecan-1 and Its Expanding List of Contacts. Advances in Wound Care. 4: 235-249. PMID 25945286 DOI: 10.1089/Wound.2014.0555  0.745
2014 Pal-Ghosh S, Pajoohesh-Ganji A, Menko AS, Oh HY, Tadvalkar G, Saban DR, Stepp MA. Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury. Investigative Ophthalmology & Visual Science. 55: 2757-65. PMID 24677104 DOI: 10.1167/Iovs.13-13557  0.753
2014 Pajoohesh-Ganji A, Burns MP, Pal-Ghosh S, Tadvalkar G, Hokenbury NG, Stepp MA, Faden AI. Inhibition of amyloid precursor protein secretases reduces recovery after spinal cord injury. Brain Research. 1560: 73-82. PMID 24630972 DOI: 10.1016/J.Brainres.2014.02.049  0.702
2014 Stepp MA, Zieske JD, Trinkaus-Randall V, Kyne BM, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Wounding the cornea to learn how it heals. Experimental Eye Research. 121: 178-93. PMID 24607489 DOI: 10.1016/J.Exer.2014.02.007  0.721
2014 Menko AS, Bleaken BM, Libowitz AA, Zhang L, Stepp MA, Walker JL. A central role for vimentin in regulating repair function during healing of the lens epithelium. Molecular Biology of the Cell. 25: 776-90. PMID 24478454 DOI: 10.1091/Mbc.E12-12-0900  0.473
2012 Volotskova O, Hawley TS, Stepp MA, Keidar M. Targeting the cancer cell cycle by cold atmospheric plasma. Scientific Reports. 2: 636. PMID 22957140 DOI: 10.1038/Srep00636  0.352
2012 Pajoohesh-Ganji A, Pal-Ghosh S, Tadvalkar G, Stepp MA. Corneal goblet cells and their niche: implications for corneal stem cell deficiency. Stem Cells (Dayton, Ohio). 30: 2032-43. PMID 22821715 DOI: 10.1002/Stem.1176  0.743
2012 Padmakumar VC, Speer K, Pal-Ghosh S, Masiuk KE, Ryscavage A, Dengler SL, Hwang S, Edwards JC, Coppola V, Tessarollo L, Stepp MA, Yuspa SH. Spontaneous skin erosions and reduced skin and corneal wound healing characterize CLIC4(NULL) mice. The American Journal of Pathology. 181: 74-84. PMID 22613027 DOI: 10.1016/J.Ajpath.2012.03.025  0.441
2012 Volotskova O, Stepp MA, Keidar M. Integrin activation by a cold atmospheric plasma jet New Journal of Physics. 14. DOI: 10.1088/1367-2630/14/5/053019  0.46
2011 Pal-Ghosh S, Pajoohesh-Ganji A, Tadvalkar G, Stepp MA. Removal of the basement membrane enhances corneal wound healing. Experimental Eye Research. 93: 927-36. PMID 22067129 DOI: 10.1016/J.Exer.2011.10.012  0.755
2011 Blanco-Mezquita JT, Hutcheon AEK, Stepp MA, Zieske JD. αVβ6 integrin promotes corneal wound healing Investigative Ophthalmology and Visual Science. 52: 8505-8513. PMID 21960555 DOI: 10.1167/Iovs.11-8194  0.424
2011 Pal-Ghosh S, Blanco T, Tadvalkar G, Pajoohesh-Ganji A, Parthasarathy A, Zieske JD, Stepp MA. MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice. Journal of Cell Science. 124: 2666-75. PMID 21750188 DOI: 10.1242/Jcs.085480  0.706
2011 Velasco J, Li J, DiPietro L, Stepp MA, Sandy JD, Plaas A. Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling. The Journal of Biological Chemistry. 286: 26016-27. PMID 21566131 DOI: 10.1074/Jbc.M110.208694  0.45
2010 Stepp MA, Daley WP, Bernstein AM, Pal-Ghosh S, Tadvalkar G, Shashurin A, Palsen S, Jurjus RA, Larsen M. Syndecan-1 regulates cell migration and fibronectin fibril assembly. Experimental Cell Research. 316: 2322-39. PMID 20580707 DOI: 10.1016/J.Yexcr.2010.05.020  0.737
2010 Stepp MA, Pal-Ghosh S, Tadvalkar G, Rajjoub L, Jurjus RA, Gerdes M, Ryscavage A, Cataisson C, Shukla A, Yuspa SH. Loss of syndecan-1 is associated with malignant conversion in skin carcinogenesis. Molecular Carcinogenesis. 49: 363-73. PMID 20082322 DOI: 10.1002/Mc.20609  0.726
2010 Shashurin A, Stepp MA, Hawley TS, Pal-Ghosh S, Brieda L, Bronnikov S, Jurjus RA, Keidar M. Influence of cold plasma atmospheric jet on surface integrin expression of living cells Plasma Processes and Polymers. 7: 294-300. DOI: 10.1002/Ppap.200900086  0.727
2009 Singh P, Chen C, Pal-Ghosh S, Stepp MA, Sheppard D, Van De Water L. Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. The Journal of Investigative Dermatology. 129: 217-28. PMID 18633440 DOI: 10.1038/Jid.2008.201  0.5
2008 Jurjus RA, Liu Y, Pal-Ghosh S, Tadvalkar G, Stepp MA. Primary dermal fibroblasts derived from sdc-1 deficient mice migrate faster and have altered alphav integrin function. Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. 16: 649-60. PMID 19128260 DOI: 10.1111/J.1524-475X.2008.00423.X  0.757
2008 Pal-Ghosh S, Tadvalkar G, Jurjus RA, Zieske JD, Stepp MA. BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds. Experimental Eye Research. 87: 478-86. PMID 18809399 DOI: 10.1016/J.Exer.2008.08.013  0.723
2008 Mayo C, Ren R, Rich C, Stepp MA, Trinkaus-Randall V. Regulation by P2X7: epithelial migration and stromal organization in the cornea. Investigative Ophthalmology & Visual Science. 49: 4384-91. PMID 18502993 DOI: 10.1167/Iovs.08-1688  0.374
2008 Shashurin A, Keidar M, Bronnikov S, Jurjus RA, Stepp MA. Living tissue under treatment of cold plasma atmospheric jet Applied Physics Letters. 93. DOI: 10.1063/1.3020223  0.677
2007 Stepp MA, Liu Y, Pal-Ghosh S, Jurjus RA, Tadvalkar G, Sekaran A, Losicco K, Jiang L, Larsen M, Li L, Yuspa SH. Reduced migration, altered matrix and enhanced TGFbeta1 signaling are signatures of mouse keratinocytes lacking Sdc1. Journal of Cell Science. 120: 2851-63. PMID 17666434 DOI: 10.1242/Jcs.03480  0.729
2007 Vanhoutte D, Schellings MW, Götte M, Swinnen M, Herias V, Wild MK, Vestweber D, Chorianopoulos E, Cortés V, Rigotti A, Stepp MA, Van de Werf F, Carmeliet P, Pinto YM, Heymans S. Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction. Circulation. 115: 475-82. PMID 17242279 DOI: 10.1161/Circulationaha.106.644609  0.343
2006 Stepp MA. Corneal integrins and their functions Experimental Eye Research. 83: 3-15. PMID 16580666 DOI: 10.1016/J.Exer.2006.01.010  0.412
2006 Pajoohesh-Ganji A, Pal-Ghosh S, Simmens SJ, Stepp MA. Integrins in slow-cycling corneal epithelial cells at the limbus in the mouse. Stem Cells (Dayton, Ohio). 24: 1075-86. PMID 16282441 DOI: 10.1634/Stemcells.2005-0382  0.72
2005 Hutcheon AE, Guo XQ, Stepp MA, Simon KJ, Weinreb PH, Violette SM, Zieske JD. Effect of wound type on Smad 2 and 4 translocation. Investigative Ophthalmology & Visual Science. 46: 2362-8. PMID 15980223 DOI: 10.1167/Iovs.04-0759  0.348
2005 Pajoohesh-Ganji A, Stepp MA. In search of markers for the stem cells of the corneal epithelium. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 97: 265-76. PMID 15762848 DOI: 10.1042/Bc20040114  0.715
2005 Stepp MA, Zieske JD. The corneal epithelial stem cell niche Ocular Surface. 3: 15-26. DOI: 10.1016/S1542-0124(12)70119-2  0.375
2004 Singh P, Reimer CL, Peters JH, Stepp MA, Hynes RO, Van De Water L. The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. The Journal of Investigative Dermatology. 123: 1176-81. PMID 15610531 DOI: 10.1111/J.0022-202X.2004.23485.X  0.464
2004 Gao CY, Stepp MA, Fariss R, Zelenka P. Cdk5 regulates activation and localization of Src during corneal epithelial wound closure Journal of Cell Science. 117: 4089-4098. PMID 15280426 DOI: 10.1242/Jcs.01271  0.462
2004 Pajoohesh-Ganji A, Ghosh SP, Stepp MA. Regional distribution of alpha9beta1 integrin within the limbus of the mouse ocular surface. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 230: 518-28. PMID 15188436 DOI: 10.1002/Dvdy.20050  0.736
2004 Pal-Ghosh S, Pajoohesh-Ganji A, Brown M, Stepp MA. A mouse model for the study of recurrent corneal epithelial erosions: alpha9beta1 integrin implicated in progression of the disease. Investigative Ophthalmology & Visual Science. 45: 1775-88. PMID 15161840 DOI: 10.1167/Iovs.03-1194  0.73
2003 Tomczuk M, Takahashi Y, Huang J, Murase S, Mistretta M, Klaffky E, Sutherland A, Bolling L, Coonrod S, Marcinkiewicz C, Sheppard D, Stepp MA, White JM. Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Experimental Cell Research. 290: 68-81. PMID 14516789 DOI: 10.1016/S0014-4827(03)00307-0  0.409
2002 Stepp MA, Gibson HE, Gala PH, Iglesia DD, Pajoohesh-Ganji A, Pal-Ghosh S, Brown M, Aquino C, Schwartz AM, Goldberger O, Hinkes MT, Bernfield M. Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse. Journal of Cell Science. 115: 4517-31. PMID 12414997 DOI: 10.1242/Jcs.00128  0.767
2000 Belkin AM, Stepp MA. Integrins as receptors for laminins Microscopy Research and Technique. 51: 280-301. PMID 11054877 DOI: 10.1002/1097-0029(20001101)51:3<280::Aid-Jemt7>3.0.Co;2-O  0.412
2000 Drina DD, Stepp MA. Disruption of the basement membrane after corneal debridement Investigative Ophthalmology and Visual Science. 41: 1045-1053. PMID 10752940  0.303
2000 Sta Iglesia DD, Gala PH, Qiu T, Stepp MA. Integrin expression during epithelial migration and restratification in the tenascin-C-deficient mouse cornea Journal of Histochemistry and Cytochemistry. 48: 363-375. PMID 10681390 DOI: 10.1177/002215540004800306  0.449
1999 Stepp MA. α9 and β8 Integrin expression correlates with the merger of the developing mouse eyelids Developmental Dynamics. 214: 216-228. PMID 10090148 DOI: 10.1002/(Sici)1097-0177(199903)214:3<216::Aid-Aja5>3.0.Co;2-4  0.361
1997 Widra EA, Weeraratna A, Stepp MA, Stillman RJ, Patierno SR. Modulation of implantation-associated integrin expression but not uteroglobin by steroid hormones in an endometrial cell line. Molecular Human Reproduction. 3: 563-8. PMID 9268133 DOI: 10.1093/Molehr/3.7.563  0.33
1997 Stepp MA, Zhu L. Upregulation of α9 integrin and tenascin during epithelial regeneration after debridement in the cornea Journal of Histochemistry and Cytochemistry. 45: 189-201. PMID 9016309 DOI: 10.1177/002215549704500205  0.502
1995 Stepp MA, Zhu L, Sheppard D, Cranfill RL. Localized distribution of α9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation Journal of Histochemistry and Cytochemistry. 43: 353-362. PMID 7534781 DOI: 10.1177/43.4.7534781  0.395
1994 Stepp MA, Urry LA, Hynes RO. Expression of α4 integrin mRNA and protein and fibronectin in the early chicken embryo Cell Communication and Adhesion. 2: 359-375. DOI: 10.3109/15419069409014210  0.379
1993 Stepp MA, Spurr-Michaud S, Gipson IK. Integrins in the wounded and unwounded stratified squamous epithelium of the cornea Investigative Ophthalmology and Visual Science. 34: 1829-1844. PMID 8473121  0.315
1993 Roth T, Podesta F, Stepp MA, Boeri D, Lorenzi M. Integrin overexpression induced by high glucose and by human diabetes: Potential pathway to cell dysfunction in diabetic microangiopathy Proceedings of the National Academy of Sciences of the United States of America. 90: 9640-9644. PMID 8415754 DOI: 10.1073/Pnas.90.20.9640  0.357
1993 Gipson IK, Spurr-Michaud S, Tisdale A, Elwell J, Stepp MA. Redistribution of the hemidesmosome components α6β4 integrin and bullous pemphigoid antigens during epithelial wound healing Experimental Cell Research. 207: 86-98. PMID 8319775 DOI: 10.1006/Excr.1993.1166  0.44
1992 Giancotti FG, Stepp MA, Suzuki S, Engvall E, Ruoslahti E. Proteolytic processing of endogenous and recombinant β4 integrin subunit Journal of Cell Biology. 118: 951-959. PMID 1500432 DOI: 10.1083/Jcb.118.4.951  0.34
1992 Stepp MA, Gipson IK. The role of integrins in corneal epithelial wound healing Experimental Eye Research. 55: 212. DOI: 10.1016/0014-4835(92)90960-Z  0.446
1990 Stepp MA, Spurr-Michaud S, Tisdale A, Elwell J, Gipson IK. α6β4 integrin heterodimer is a component of hemidesmosomes Proceedings of the National Academy of Sciences of the United States of America. 87: 8970-8974. PMID 2247472 DOI: 10.1073/Pnas.87.22.8970  0.392
1989 Hynes RO, Marcantonio EE, Stepp MA, Urry LA, Yee GH. Integrin heterodimer and receptor complexity in avian and mammalian cells. The Journal of Cell Biology. 109: 409-20. PMID 2663881 DOI: 10.1083/Jcb.109.1.409  0.318
1986 Stepp MA, Kindy MS, Franzblau C, Sonenshein GE. Complex regulation of collagen gene expression in cultured bovine aortic smooth muscle cells Journal of Biological Chemistry. 261: 6542-6547. PMID 3700407  0.567
1985 Stepp MA, Kindy M, Franzblau C, Sonenshein G. Cloning of Type III Collagen and Expression in Aortic Smooth Muscle Cells Annals of the New York Academy of Sciences. 460: 510-513. DOI: 10.1111/J.1749-6632.1985.Tb51225.X  0.565
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