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Jennifer A. Maynard, Ph.D. - Publications

Affiliations: 
2001 University of Texas at Austin, Austin, Texas, U.S.A. 
Area:
discovery and development of protein therapeutics and applied immunology by capitalizing on state of the art protein engineering, directed evolution and systems biology technologies
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61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Siles N, Schuler M, Maguire C, Amengor D, Nguyen A, Wilen R, Rogers J, Bazzi S, Caslin B, DiPasquale C, Abigania M, Olson E, Creaturo J, Hurley K, Triplett TA, ... ... Maynard J, et al. SARS-CoV-2 Humoral Immune Responses in Convalescent Individuals Over 12 Months Reveal Severity-Dependent Antibody Dynamics. Medrxiv : the Preprint Server For Health Sciences. PMID 38106077 DOI: 10.1101/2023.12.05.23299462  0.333
2023 Maynard JA, Segatori L. Editorial overview: Tissue, cell, and pathway engineering: Recent innovations in biomedical technologies. Current Opinion in Biotechnology. 83: 102981. PMID 37591033 DOI: 10.1016/j.copbio.2023.102981  0.582
2023 Silva RP, Huang Y, Nguyen AW, Hsieh CL, Olaluwoye OS, Kaoud TS, Wilen RE, Qerqez AN, Park JG, Khalil AM, Azouz LR, Le KC, Bohanon AL, DiVenere AM, Liu Y, ... ... Maynard JA, et al. Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses. Elife. 12. PMID 36942851 DOI: 10.7554/eLife.83710  0.433
2023 Qerqez AN, Silva RP, Maynard JA. Outsmarting Pathogens with Antibody Engineering. Annual Review of Chemical and Biomolecular Engineering. PMID 36917814 DOI: 10.1146/annurev-chembioeng-101121-084508  0.417
2022 Bowen JE, Park YJ, Stewart C, Brown JT, Sharkey WK, Walls AC, Joshi A, Sprouse KR, McCallum M, Tortorici MA, Franko NM, Logue JK, Mazzitelli IG, Nguyen AW, Silva RP, ... ... Maynard JA, et al. SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines. Science Immunology. eadf1421. PMID 36356052 DOI: 10.1126/sciimmunol.adf1421  0.35
2022 Liu Y, Nguyen AW, Maynard JA. Engineering antibodies for conditional activity in the solid tumor microenvironment. Current Opinion in Biotechnology. 78: 102809. PMID 36182870 DOI: 10.1016/j.copbio.2022.102809  0.33
2022 Goldsmith JA, DiVenere AM, Maynard JA, McLellan JS. Structural basis for non-canonical integrin engagement by Bordetella adenylate cyclase toxin. Cell Reports. 40: 111196. PMID 35977491 DOI: 10.1016/j.celrep.2022.111196  0.38
2022 DiVenere AM, Amengor D, Silva RP, Goldsmith JA, McLellan JS, Maynard JA. Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis. Mbio. e0152722. PMID 35920558 DOI: 10.1128/mbio.01527-22  0.467
2022 Liu Y, Lee AG, Nguyen AW, Maynard JA. An antibody Fc engineered for conditional antibody-dependent cellular cytotoxicity at the low tumor microenvironment pH using mammalian cell display. The Journal of Biological Chemistry. 101798. PMID 35248534 DOI: 10.1016/j.jbc.2022.101798  0.321
2022 Costello SM, Shoemaker SR, Hobbs HT, Nguyen AW, Hsieh CL, Maynard JA, McLellan JS, Pak JE, Marqusee S. The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes. Nature Structural & Molecular Biology. PMID 35236990 DOI: 10.1038/s41594-022-00735-5  0.332
2022 Silva RP, DiVenere AM, Amengor D, Maynard JA. Antibodies binding diverse pertactin epitopes protect mice from B. pertussis infection. The Journal of Biological Chemistry. 101715. PMID 35151691 DOI: 10.1016/j.jbc.2022.101715  0.475
2021 Goldsmith JA, DiVenere AM, Maynard JA, McLellan JS. Structural basis for antibody binding to adenylate cyclase toxin reveals RTX linkers as neutralization-sensitive epitopes. Plos Pathogens. 17: e1009920. PMID 34547035 DOI: 10.1371/journal.ppat.1009920  0.429
2021 Patterson-Orazem AC, Qerqez AN, Azouz LR, Ma MT, Hill SE, Ku Y, Schildmeyer LA, Maynard JA, Lieberman RL. Recombinant antibodies recognize conformation-dependent epitopes of the leucine zipper of misfolding-prone myocilin. The Journal of Biological Chemistry. 101067. PMID 34384785 DOI: 10.1016/j.jbc.2021.101067  0.388
2020 Hsieh CL, Goldsmith JA, Schaub JM, DiVenere AM, Kuo HC, Javanmardi K, Le KC, Wrapp D, Lee AG, Liu Y, Chou CW, Byrne PO, Hjorth CK, Johnson NV, Ludes-Meyers J, ... ... Maynard JA, et al. Structure-based design of prefusion-stabilized SARS-CoV-2 spikes. Science (New York, N.Y.). PMID 32703906 DOI: 10.1126/Science.Abd0826  0.322
2020 Tanno H, McDaniel JR, Stevens CA, Voss WN, Li J, Durrett R, Lee J, Gollihar J, Tanno Y, Delidakis G, Pothukuchy A, Ellefson JW, Goronzy JJ, Maynard JA, Ellington AD, et al. A facile technology for the high-throughput sequencing of the paired VH:VL and TCRβ:TCRα repertoires. Science Advances. 6: eaay9093. PMID 32426460 DOI: 10.1126/Sciadv.Aay9093  0.604
2020 Nguyen AW, DiVenere AM, Papin JF, Connelly S, Kaleko M, Maynard JA. Neutralization of pertussis toxin by a single antibody prevents clinical pertussis in neonatal baboons. Science Advances. 6: eaay9258. PMID 32076653 DOI: 10.1126/Sciadv.Aay9258  0.463
2020 Nguyen AW, Le K, Maynard JA. Engineering Antibodies on the Surface of CHO Cells. Methods in Molecular Biology (Clifton, N.J.). 2070: 397-422. PMID 31625108 DOI: 10.1007/978-1-4939-9853-1_22  0.521
2019 Wagner EK, Qerqez AN, Stevens CA, Nguyen AW, Delidakis G, Maynard JA. Human cytomegalovirus-specific T cell receptor engineered for high affinity and soluble expression using mammalian cell display. The Journal of Biological Chemistry. PMID 30796163 DOI: 10.1074/Jbc.Ra118.007187  0.481
2018 Acquaye-Seedah E, Huang Y, Sutherland JN, DiVenere AM, Maynard JA. Humanized monoclonal antibodies neutralize pertussis toxin by receptor blockade and reduced retrograde trafficking. Cellular Microbiology. e12948. PMID 30152075 DOI: 10.1111/Cmi.12948  0.779
2018 Boehm DT, Hall JM, Wong TY, DiVenere A, Sen-Kilic E, Bevere JR, Bradford SD, Blackwood CB, Elkins C, DeRoos KA, Gray MC, Cooper CG, Varney ME, Maynard JA, Hewlett EL, et al. Evaluation of adenylate cyclase toxoid antigen in acellular pertussis vaccines using a challenge model in mice. Infection and Immunity. PMID 30012638 DOI: 10.1128/Iai.00857-17  0.388
2018 Wagner EK, Maynard JA. Engineering therapeutic antibodies to combat infectious diseases. Current Opinion in Chemical Engineering. 19: 131-141. PMID 29911002 DOI: 10.1016/J.Coche.2018.01.007  0.509
2018 Acquaye-Seedah E, Reczek EE, Russell HH, DiVenere AM, Sandman SO, Collins JH, Stein CA, Whitehead TA, Maynard JA. Characterization of individual human antibodies binding pertussis toxin stimulated by acellular immunization. Infection and Immunity. PMID 29581192 DOI: 10.1128/Iai.00004-18  0.556
2018 Nguyen AW, Le KC, Maynard JA. Identification of high affinity HER2 binding antibodies using CHO Fab surface display. Protein Engineering, Design & Selection : Peds. PMID 29566240 DOI: 10.1093/Protein/Gzy004  0.527
2018 Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, et al. When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions. Mabs. 1-19. PMID 29485921 DOI: 10.1080/19420862.2018.1445456  0.468
2017 Entzminger KC, Hyun JM, Pantazes RJ, Patterson-Orazem AC, Qerqez AN, Frye ZP, Hughes RA, Ellington AD, Lieberman RL, Maranas CD, Maynard JA. De novo design of antibody complementarity determining regions binding a FLAG tetra-peptide. Scientific Reports. 7: 10295. PMID 28860479 DOI: 10.1038/S41598-017-10737-9  0.491
2017 Wang X, Stapleton JA, Klesmith JR, Hewlett EL, Whitehead TA, Maynard JA. Fine epitope mapping of two antibodies neutralizing the Bordetella adenylate cyclase toxin. Biochemistry. PMID 28177609 DOI: 10.1021/Acs.Biochem.6B01163  0.565
2017 Maynard J, Nguyen A, Wolf R, Papin J, Connelly S, Kaleko M. Passive Immunization with Anti-Pertussis Toxin Humanized Monoclonal Antibody Mitigates Clinical Signs of Pertussis Infection in Newborn Baboons Open Forum Infectious Diseases. 4: S4-S5. DOI: 10.1093/Ofid/Ofx162.009  0.433
2016 Nguyen AW, Wagner EK, Posada L, Liu X, Connelly S, Papin JF, Wolf RF, Kaleko M, Maynard JA. Prior exposure to Bordetella species as an exclusion criterion in the baboon model of pertussis. The Journal of Veterinary Medical Science / the Japanese Society of Veterinary Science. PMID 27666464 DOI: 10.1292/Jvms.16-0427  0.349
2016 Wagner EK, Wang X, Bui A, Maynard JA. Synergistic neutralization of pertussis toxin by a bispecific antibody in vitro and in vivo. Clinical and Vaccine Immunology : Cvi. PMID 27581436 DOI: 10.1128/Cvi.00371-16  0.553
2016 Khan TA, Wang X, Maynard JA. Inclusion of an RGD Motif Alters Invasin Integrin-Binding Affinity and Specificity. Biochemistry. PMID 27015583 DOI: 10.1021/Acs.Biochem.5B01243  0.392
2016 Borwankar AU, Dear BJ, Twu A, Hung JJ, Dinin AK, Wilson BK, Yue J, Maynard JA, Truskett TM, Johnston KP. Viscosity Reduction of a Concentrated Monoclonal Antibody with Arginine·HCl and Arginine·Glutamate Industrial & Engineering Chemistry Research. 55: 11225-11234. DOI: 10.1021/Acs.Iecr.6B02042  0.39
2015 Nguyen AW, Wagner EK, Laber JR, Goodfield LL, Smallridge WE, Harvill ET, Papin JF, Wolf RF, Padlan EA, Bristol A, Kaleko M, Maynard JA. A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough. Science Translational Medicine. 7: 316ra195. PMID 26631634 DOI: 10.1126/Scitranslmed.Aad0966  0.488
2015 Wang X, Gray MC, Hewlett EL, Maynard JA. The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies. The Journal of Biological Chemistry. 290: 23025. PMID 26386047 DOI: 10.1074/Jbc.A114.585281  0.45
2015 Kowalsky CA, Faber MS, Nath A, Dann HE, Kelly VW, Liu L, Shanker P, Wagner EK, Maynard JA, Chan C, Whitehead TA. Rapid Fine Conformational Epitope Mapping Using Comprehensive Mutagenesis and Deep Sequencing. The Journal of Biological Chemistry. PMID 26296891 DOI: 10.1074/Jbc.M115.676635  0.477
2015 Entzminger KC, Johnson JL, Hyun J, Lieberman RL, Maynard JA. Increased Fab thermoresistance via VH-targeted directed evolution. Protein Engineering, Design & Selection : Peds. PMID 26283664 DOI: 10.1093/Protein/Gzv037  0.431
2015 Johnson JL, Entzminger KC, Hyun J, Kalyoncu S, Heaner DP, Morales IA, Sheppard A, Gumbart JC, Maynard JA, Lieberman RL. Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization. Acta Crystallographica. Section D, Biological Crystallography. 71: 896-906. PMID 25849400 DOI: 10.1107/S1399004715001856  0.408
2015 Wang X, Maynard JA. The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies. The Journal of Biological Chemistry. 290: 3576-91. PMID 25505186 DOI: 10.1074/Jbc.M114.585281  0.415
2014 Seedah EA, Frye ZP, Maynard JA. Immunotherapeutic Approaches To Prevent Cytomegalovirus-Mediated Disease. Microbiology Spectrum. 2: AID-0009-2013. PMID 26082112 DOI: 10.1128/Microbiolspec.Aid-0009-13  0.409
2014 Kalyoncu S, Hyun J, Pai JC, Johnson JL, Entzminger K, Jain A, Heaner DP, Morales IA, Truskett TM, Maynard JA, Lieberman RL. Effects of protein engineering and rational mutagenesis on crystal lattice of single chain antibody fragments. Proteins. 82: 1884-95. PMID 24615866 DOI: 10.1002/Prot.24542  0.348
2014 Kalyoncu S, Johnson JL, Heaner DP, Morales IA, Hyun J, Pai JC, Etzminger K, Maynard JA, Lieberman RL. The Use of Engineered Antibody Fragments to Promote Crystallization of Membrane Proteins Biophysical Journal. 106: 46a. DOI: 10.1016/J.Bpj.2013.11.334  0.362
2013 Wang XZ, Coljee VW, Maynard JA. Back to the future: recombinant polyclonal antibody therapeutics. Current Opinion in Chemical Engineering. 2: 405-415. PMID 24443710 DOI: 10.1016/J.Coche.2013.08.005  0.527
2013 Miller MA, Rodrigues MA, Glass MA, Singh SK, Johnston KP, Maynard JA. Frozen-state storage stability of a monoclonal antibody: aggregation is impacted by freezing rate and solute distribution. Journal of Pharmaceutical Sciences. 102: 1194-208. PMID 23400717 DOI: 10.1002/Jps.23473  0.317
2012 Roy BM, Zhukov DV, Maynard JA. Flanking residues are central to DO11.10 T cell hybridoma stimulation by ovalbumin 323-339. Plos One. 7: e47585. PMID 23110081 DOI: 10.1371/Journal.Pone.0047585  0.343
2012 Miller MA, Khan TA, Kaczorowski KJ, Wilson BK, Dinin AK, Borwankar AU, Rodrigues MA, Truskett TM, Johnston KP, Maynard JA. Antibody nanoparticle dispersions formed with mixtures of crowding molecules retain activity and In Vivo bioavailability Journal of Pharmaceutical Sciences. 101: 3763-3778. PMID 22777686 DOI: 10.1002/Jps.23256  0.487
2012 Entzminger KC, Chang C, Myhre RO, McCallum KC, Maynard JA. The Skp chaperone helps fold soluble proteins in vitro by inhibiting aggregation. Biochemistry. 51: 4822-34. PMID 22650963 DOI: 10.1021/Bi300412Y  0.34
2012 Johnston KP, Maynard JA, Truskett TM, Borwankar AU, Miller MA, Wilson BK, Dinin AK, Khan TA, Kaczorowski KJ. Concentrated dispersions of equilibrium protein nanoclusters that reversibly dissociate into active monomers Acs Nano. 6: 1357-1369. PMID 22260218 DOI: 10.1021/Nn204166Z  0.408
2012 Im H, Sutherland JN, Maynard JA, Oh SH. Nanohole-based surface plasmon resonance instruments with improved spectral resolution quantify a broad range of antibody-ligand binding kinetics. Analytical Chemistry. 84: 1941-7. PMID 22235895 DOI: 10.1021/Ac300070T  0.752
2012 Pai JC, Entzminger KC, Maynard JA. Restriction enzyme-free construction of random gene mutagenesis libraries in Escherichia coli. Analytical Biochemistry. 421: 640-8. PMID 22155067 DOI: 10.1016/J.Ab.2011.11.009  0.313
2011 Sutherland JN, Chang C, Yoder SM, Rock MT, Maynard JA. Antibodies recognizing protective pertussis toxin epitopes are preferentially elicited by natural infection versus acellular immunization. Clinical and Vaccine Immunology : Cvi. 18: 954-62. PMID 21508166 DOI: 10.1128/Cvi.00561-10  0.766
2011 Pai JC, Culver JA, Drury JE, Motani RS, Lieberman RL, Maynard JA. Conversion of scFv peptide-binding specificity for crystal chaperone development. Protein Engineering, Design & Selection : Peds. 24: 419-28. PMID 21217145 DOI: 10.1093/Protein/Gzq120  0.433
2009 Maynard JA, Lindquist NC, Sutherland JN, Lesuffleur A, Warrington AE, Rodriguez M, Oh SH. Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins. Biotechnology Journal. 4: 1542-58. PMID 19918786 DOI: 10.1002/Biot.200900195  0.72
2009 Sutherland JN, Maynard JA. Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7. Biochemistry. 48: 11982-93. PMID 19899804 DOI: 10.1021/Bi901532Z  0.765
2009 Leysath CE, Monzingo AF, Maynard JA, Barnett J, Georgiou G, Iverson BL, Robertus JD. Crystal structure of the engineered neutralizing antibody M18 complexed to domain 4 of the anthrax protective antigen. Journal of Molecular Biology. 387: 680-93. PMID 19361425 DOI: 10.1016/J.Jmb.2009.02.003  0.635
2009 Pai JC, Sutherland JN, Maynard JA. Progress towards recombinant anti-infective antibodies. Recent Patents On Anti-Infective Drug Discovery. 4: 1-17. PMID 19149692 DOI: 10.2174/157489109787236319  0.767
2008 Sivasubramanian A, Maynard JA, Gray JJ. Modeling the structure of mAb 14B7 bound to the anthrax protective antigen. Proteins. 70: 218-30. PMID 17671962 DOI: 10.1002/Prot.21595  0.476
2007 Maynard JA, Myhre R, Roy B. Microarrays in infection and immunity. Current Opinion in Chemical Biology. 11: 306-15. PMID 17500025 DOI: 10.1016/J.Cbpa.2007.01.727  0.346
2005 Maynard J, Adams EJ, Krogsgaard M, Petersson K, Liu CW, Garcia KC. High-level bacterial secretion of single-chain αβ T-cell receptors Journal of Immunological Methods. 306: 51-67. PMID 16198365 DOI: 10.1016/J.Jim.2005.07.022  0.333
2005 Maynard J, Petersson K, Wilson DH, Adams EJ, Blondelle SE, Boulanger MJ, Wilson DB, Garcia KC. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity. 22: 81-92. PMID 15664161 DOI: 10.1016/J.Immuni.2004.11.015  0.307
2002 Maynard JA, Maassen CB, Leppla SH, Brasky K, Patterson JL, Iverson BL, Georgiou G. Protection against anthrax toxin by recombinant antibody fragments correlates with antigen affinity. Nature Biotechnology. 20: 597-601. PMID 12042864 DOI: 10.1038/Nbt0602-597  0.628
2002 Maynard JA, Chen G, Georgiou G, Iverson BL. In vitro scanning-saturation mutagenesis. Methods in Molecular Biology (Clifton, N.J.). 182: 149-63. PMID 11768962 DOI: 10.1385/1-59259-194-9:149  0.408
2000 Maynard J, Georgiou G. Antibody engineering Annual Review of Biomedical Engineering. 2: 339-376. PMID 11701516  0.439
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