| Year |
Citation |
Score |
| 2022 |
Elmansi AM, Eisa NH, Periyasamy-Thandavan S, Kondrikova G, Kondrikov D, Calkins MM, Aguilar-Pérez A, Chen J, Johnson M, Shi XM, Reitman C, McGee-Lawrence ME, Crawford KS, Dwinell MB, Volkman BF, ... ... Luttrell LM, et al. DPP4-Truncated CXCL12 Alters CXCR4/ACKR3 Signaling, Osteogenic Cell Differentiation, Migration, and Senescence. Acs Pharmacology & Translational Science. 6: 22-39. PMID 36659961 DOI: 10.1021/acsptsci.2c00040 |
0.319 |
|
| 2020 |
van Gastel J, Leysen H, Boddaert J, van Genechten L, Luttrell LM, Martin B, Maudsley S. Aging-related modifications to G protein-coupled receptor signaling diversity. Pharmacology & Therapeutics. 107793. PMID 33316288 DOI: 10.1016/j.pharmthera.2020.107793 |
0.31 |
|
| 2020 |
Liu S, Luttrell LM, Premont RT, Rockey DC. Reply to Schierwagen et al.: β-Arrestins in liver disease. Proceedings of the National Academy of Sciences of the United States of America. 117: 27085-27086. PMID 33144523 DOI: 10.1073/pnas.2014931117 |
0.439 |
|
| 2020 |
Ahn S, Shenoy SK, Luttrell LM, Lefkowitz RJ. SnapShot: β-Arrestin Functions. Cell. 182: 1362-1362.e1. PMID 32888497 DOI: 10.1016/J.Cell.2020.07.034 |
0.789 |
|
| 2020 |
Liu S, Luttrell LM, Premont RT, Rockey DC. β-Arrestin2 is a critical component of the GPCR-eNOS signalosome. Proceedings of the National Academy of Sciences of the United States of America. PMID 32404425 DOI: 10.1073/Pnas.1922608117 |
0.583 |
|
| 2019 |
Ghosh E, Dwivedi H, Baidya M, Srivastava A, Kumari P, Stepniewski T, Kim HR, Lee MH, van Gastel J, Chaturvedi M, Roy D, Pandey S, Maharana J, Guixà-González R, Luttrell LM, et al. Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms. Cell Reports. 28: 3287-3299.e6. PMID 31553900 DOI: 10.1016/J.Celrep.2019.08.053 |
0.549 |
|
| 2019 |
Strungs EG, Luttrell LM, Lee MH. Probing Arrestin Function Using Intramolecular FlAsH-BRET Biosensors. Methods in Molecular Biology (Clifton, N.J.). 1957: 309-322. PMID 30919362 DOI: 10.1007/978-1-4939-9158-7_19 |
0.327 |
|
| 2018 |
van Gastel J, Hendrickx JO, Leysen H, Santos-Otte P, Luttrell LM, Martin B, Maudsley S. β-Arrestin Based Receptor Signaling Paradigms: Potential Therapeutic Targets for Complex Age-Related Disorders. Frontiers in Pharmacology. 9: 1369. PMID 30546309 DOI: 10.3389/Fphar.2018.01369 |
0.647 |
|
| 2018 |
Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, et al. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Science Signaling. 11. PMID 30254056 DOI: 10.1126/Scisignal.Aat7650 |
0.835 |
|
| 2018 |
van Gastel J, Boddaert J, Jushaj A, Premont RT, Luttrell LM, Janssens J, Martin B, Maudsley S. GIT2-a keystone in ageing and age-related disease. Ageing Research Reviews. PMID 29452267 DOI: 10.1016/J.Arr.2018.02.002 |
0.705 |
|
| 2017 |
Peterson YK, Luttrell LM. The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling. Pharmacological Reviews. 69: 256-297. PMID 28626043 DOI: 10.1124/pr.116.013367 |
0.391 |
|
| 2017 |
Luttrell LM, Maudsley S, Gesty-Palmer D. Translating in vitro ligand bias into in vivo efficacy. Cellular Signalling. PMID 28495495 DOI: 10.1016/J.Cellsig.2017.05.002 |
0.655 |
|
| 2016 |
Morinelli TA, Luttrell LM, Strungs EG, Ullian ME. Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis. The International Journal of Biochemistry & Cell Biology. PMID 27167177 DOI: 10.1016/j.biocel.2016.04.016 |
0.3 |
|
| 2016 |
Lee MH, Appleton KM, Strungs EG, Kwon JY, Morinelli TA, Peterson YK, Laporte SA, Luttrell LM. The conformational signature of β-arrestin2 predicts its trafficking and signalling functions. Nature. PMID 27007854 DOI: 10.1038/Nature17154 |
0.39 |
|
| 2015 |
Williams GR, Bethard JR, Berkaw MN, Nagel AK, Luttrell LM, Ball LE. Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics. Methods (San Diego, Calif.). PMID 26160508 DOI: 10.1016/j.ymeth.2015.06.022 |
0.497 |
|
| 2015 |
Luttrell LM, Maudsley S, Bohn LM. Fulfilling the Promise of 'Biased' GPCR Agonism. Molecular Pharmacology. PMID 26134495 DOI: 10.1124/Mol.115.099630 |
0.601 |
|
| 2015 |
Maudsley S, Martin B, Janssens J, Etienne H, Jushaj A, van Gastel J, Willemsen A, Chen H, Gesty-Palmer D, Luttrell LM. Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation. Methods (San Diego, Calif.). PMID 25986936 DOI: 10.1016/J.Ymeth.2015.05.013 |
0.671 |
|
| 2015 |
Wilson PC, Fitzgibbon WR, Garrett SM, Jaffa AA, Luttrell LM, Brands MW, El-Shewy HM. Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel. Molecular Endocrinology (Baltimore, Md.). 29: 896-908. PMID 25871850 DOI: 10.1210/Me.2014-1388 |
0.529 |
|
| 2015 |
Maudsley S, Martin B, Gesty-Palmer D, Cheung H, Johnson C, Patel S, Becker KG, Wood WH, Zhang Y, Lehrmann E, Luttrell LM. Delineation of a conserved arrestin-biased signaling repertoire in vivo. Molecular Pharmacology. 87: 706-17. PMID 25637603 DOI: 10.1124/Mol.114.095224 |
0.635 |
|
| 2014 |
Kendall RT, Lee MH, Pleasant DL, Robinson K, Kuppuswamy D, McDermott PJ, Luttrell LM. Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis. The Journal of Biological Chemistry. 289: 26155-66. PMID 25081544 DOI: 10.1074/Jbc.M114.595728 |
0.527 |
|
| 2014 |
Coaxum SD, Blanton MG, Joyner A, Akter T, Bell PD, Luttrell LM, Raymond JR, Lee MH, Blichmann PA, Garnovskaya MN, Saigusa T. Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger. American Journal of Physiology. Cell Physiology. 307: C554-60. PMID 25055824 DOI: 10.1152/ajpcell.00188.2014 |
0.322 |
|
| 2014 |
Strungs EG, Luttrell LM. Arrestin-dependent activation of ERK and Src family kinases. Handbook of Experimental Pharmacology. 219: 225-57. PMID 24292833 DOI: 10.1007/978-3-642-41199-1_12 |
0.334 |
|
| 2013 |
Luttrell LM, Miller WE. Arrestins as regulators of kinases and phosphatases. Progress in Molecular Biology and Translational Science. 118: 115-47. PMID 23764052 DOI: 10.1016/B978-0-12-394440-5.00005-X |
0.727 |
|
| 2013 |
Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA. The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers. The Journal of Biological Chemistry. 288: 18872-84. PMID 23661707 DOI: 10.1074/Jbc.M113.472381 |
0.581 |
|
| 2013 |
Chen H, Martin B, Daimon CM, Siddiqui S, Luttrell LM, Maudsley S. Textrous!: extracting semantic textual meaning from gene sets. Plos One. 8: e62665. PMID 23646135 DOI: 10.1371/Journal.Pone.0062665 |
0.44 |
|
| 2013 |
Appleton KM, Luttrell LM. Emergent biological properties of arrestin pathway-selective biased agonism. Journal of Receptor and Signal Transduction Research. 33: 153-61. PMID 23448506 DOI: 10.3109/10799893.2013.769004 |
0.369 |
|
| 2013 |
Appleton KM, Lee MH, Alele C, Alele C, Luttrell DK, Peterson YK, Morinelli TA, Luttrell LM. Biasing the parathyroid hormone receptor: relating in vitro ligand efficacy to in vivo biological activity. Methods in Enzymology. 522: 229-62. PMID 23374189 DOI: 10.1016/B978-0-12-407865-9.00013-3 |
0.41 |
|
| 2013 |
Leonard AP, Appleton KM, Luttrell LM, Peterson YK. A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 19: 150-70. PMID 23351552 DOI: 10.1017/S1431927612014067 |
0.337 |
|
| 2013 |
Gesty-Palmer D, Yuan L, Martin B, Wood WH, Lee MH, Janech MG, Tsoi LC, Zheng WJ, Luttrell LM, Maudsley S. β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo. Molecular Endocrinology (Baltimore, Md.). 27: 296-314. PMID 23315939 DOI: 10.1210/Me.2012-1091 |
0.69 |
|
| 2012 |
Maudsley S, Patel SA, Park SS, Luttrell LM, Martin B. Functional signaling biases in G protein-coupled receptors: Game theory and receptor dynamics Mini-Reviews in Medicinal Chemistry. 12: 831-840. PMID 22681251 DOI: 10.2174/138955712800959071 |
0.67 |
|
| 2012 |
El-Shewy HM, Sohn M, Wilson P, Lee MH, Hammad SM, Luttrell LM, Jaffa AA. Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells. Molecular Endocrinology (Baltimore, Md.). 26: 833-45. PMID 22422617 DOI: 10.1210/Me.2011-1261 |
0.667 |
|
| 2011 |
El-Shewy HM, Abdel-Samie SA, Al Qalam AM, Lee MH, Kitatani K, Anelli V, Jaffa AA, Obeid LM, Luttrell LM. Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation. Molecular Endocrinology (Baltimore, Md.). 25: 2144-56. PMID 22016563 DOI: 10.1210/Me.2011-0101 |
0.637 |
|
| 2011 |
Gesty-Palmer D, Luttrell LM. Refining efficacy: exploiting functional selectivity for drug discovery. Advances in Pharmacology (San Diego, Calif.). 62: 79-107. PMID 21907907 DOI: 10.1016/B978-0-12-385952-5.00009-9 |
0.461 |
|
| 2011 |
Luttrell LM, Kenakin TP. Refining efficacy: allosterism and bias in G protein-coupled receptor signaling. Methods in Molecular Biology (Clifton, N.J.). 756: 3-35. PMID 21870218 DOI: 10.1007/978-1-61779-160-4_1 |
0.444 |
|
| 2011 |
Gesty-Palmer D, Luttrell LM. 'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass? British Journal of Pharmacology. 164: 59-67. PMID 21506957 DOI: 10.1111/j.1476-5381.2011.01450.x |
0.315 |
|
| 2011 |
Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy HM, Luttrell DK, Janech MG, Luttrell LM. The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network. The Journal of Biological Chemistry. 286: 19880-91. PMID 21502318 DOI: 10.1074/Jbc.M111.233080 |
0.512 |
|
| 2011 |
Abdallah RT, Keum JS, El-Shewy HM, Lee MH, Wang B, Gooz M, Luttrell DK, Luttrell LM, Jaffa AA. Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors (Journal of Biological Chemistry (2010) 285 (35206-35215)) Journal of Biological Chemistry. 286: 23620. DOI: 10.1074/jbc.A110.171769 |
0.353 |
|
| 2010 |
Abdallah RT, Keum JS, El-Shewy HM, Lee MH, Wang B, Gooz M, Luttrell DK, Luttrell LM, Jaffa AA. Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. The Journal of Biological Chemistry. 285: 35206-15. PMID 20826789 DOI: 10.1074/jbc.M110.171769 |
0.443 |
|
| 2010 |
Tholanikunnel BG, Joseph K, Kandasamy K, Baldys A, Raymond JR, Luttrell LM, McDermott PJ, Fernandes DJ. Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane. The Journal of Biological Chemistry. 285: 33816-25. PMID 20739277 DOI: 10.1074/jbc.M110.168229 |
0.323 |
|
| 2010 |
Dey M, Baldys A, Sumter DB, Göoz P, Luttrell LM, Raymond JR, Göoz M. Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement. The Journal of Pharmacology and Experimental Therapeutics. 334: 775-83. PMID 20566668 DOI: 10.1124/jpet.110.168054 |
0.41 |
|
| 2010 |
Luttrell LM, Gesty-Palmer D. Beyond desensitization: physiological relevance of arrestin-dependent signaling. Pharmacological Reviews. 62: 305-30. PMID 20427692 DOI: 10.1124/pr.109.002436 |
0.513 |
|
| 2009 |
Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM. A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Science Translational Medicine. 1: 1ra1. PMID 20368153 DOI: 10.1126/Scitranslmed.3000071 |
0.788 |
|
| 2009 |
Wang L, Martin B, Brenneman R, Luttrell LM, Maudsley S. Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders. The Journal of Pharmacology and Experimental Therapeutics. 331: 340-8. PMID 19667132 DOI: 10.1124/Jpet.109.156380 |
0.652 |
|
| 2009 |
Morinelli TA, Kendall RT, Luttrell LM, Walker LP, Ullian ME. Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activation Journal of Pharmacology and Experimental Therapeutics. 330: 118-124. PMID 19351865 DOI: 10.1124/jpet.109.151829 |
0.384 |
|
| 2009 |
El-Shewy HM, Luttrell LM. Insulin-like growth factor-2/mannose-6 phosphate receptors. Vitamins and Hormones. 80: 667-97. PMID 19251055 DOI: 10.1016/S0083-6729(08)00624-9 |
0.408 |
|
| 2009 |
Baldys A, Göoz M, Morinelli TA, Lee MH, Raymond JR, Luttrell LM, Raymond JR. Essential role of c-Cbl in amphiregulin-induced recycling and signaling of the endogenous epidermal growth factor receptor. Biochemistry. 48: 1462-73. PMID 19173594 DOI: 10.1021/bi801771g |
0.394 |
|
| 2009 |
Zimmerman B, Simaan M, Lee MH, Luttrell LM, Laporte SA. c-Src-mediated phosphorylation of AP-2 reveals a general mechanism for receptors internalizing through the clathrin pathway. Cellular Signalling. 21: 103-10. PMID 18938240 DOI: 10.1016/j.cellsig.2008.09.013 |
0.589 |
|
| 2008 |
Lee MH, Klein RL, El-Shewy HM, Luttrell DK, Luttrell LM. The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth. Biochemistry. 47: 11682-92. PMID 18842004 DOI: 10.1021/bi801451f |
0.437 |
|
| 2008 |
Gesty-Palmer D, Luttrell LM. Heptahelical terpsichory. Who calls the tune? Journal of Receptor and Signal Transduction Research. 28: 39-58. PMID 18437629 DOI: 10.1080/10799890801941921 |
0.446 |
|
| 2008 |
Luttrell LM. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Molecular Biotechnology. 39: 239-64. PMID 18240029 DOI: 10.1007/s12033-008-9031-1 |
0.476 |
|
| 2008 |
Lee MH, El-Shewy HM, Luttrell DK, Luttrell LM. Role of beta-arrestin-mediated desensitization and signaling in the control of angiotensin AT1a receptor-stimulated transcription. The Journal of Biological Chemistry. 283: 2088-97. PMID 18006496 DOI: 10.1074/jbc.M706892200 |
0.587 |
|
| 2007 |
Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ. Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. The Journal of Biological Chemistry. 282: 29549-62. PMID 17666399 DOI: 10.1074/Jbc.M700852200 |
0.81 |
|
| 2007 |
El-Shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM. The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. The Journal of Biological Chemistry. 282: 26150-7. PMID 17620336 DOI: 10.1074/Jbc.M703276200 |
0.597 |
|
| 2007 |
Fan H, Luttrell LM, Tempel GE, Senn JJ, Halushka PV, Cook JA. Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression. Molecular Immunology. 44: 3092-9. PMID 17418896 DOI: 10.1016/j.molimm.2007.02.009 |
0.35 |
|
| 2007 |
Maudsley S, Martin B, Luttrell LM. G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeutics. Current Alzheimer Research. 4: 3-19. PMID 17316162 DOI: 10.2174/156720507779939850 |
0.701 |
|
| 2007 |
Morinelli TA, Raymond JR, Baldys A, Yang Q, Lee MH, Luttrell L, Ullian ME. Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation. American Journal of Physiology. Cell Physiology. 292: C1398-408. PMID 17166941 DOI: 10.1152/Ajpcell.00337.2006 |
0.436 |
|
| 2006 |
El-Shewy HM, Johnson KR, Lee MH, Jaffa AA, Obeid LM, Luttrell LM. Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors. The Journal of Biological Chemistry. 281: 31399-407. PMID 16926156 DOI: 10.1074/Jbc.M605339200 |
0.695 |
|
| 2006 |
Luttrell LM. Transmembrane signaling by G protein-coupled receptors. Methods in Molecular Biology (Clifton, N.J.). 332: 3-49. PMID 16878684 DOI: 10.1385/1-59745-048-0:1 |
0.513 |
|
| 2006 |
Smith NJ, Luttrell LM. Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease. Hypertension. 48: 173-9. PMID 16818801 DOI: 10.1161/01.HYP.0000232641.84521.92 |
0.389 |
|
| 2006 |
Göoz M, Göoz P, Luttrell LM, Raymond JR. 5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells. The Journal of Biological Chemistry. 281: 21004-12. PMID 16737974 DOI: 10.1074/jbc.M512096200 |
0.382 |
|
| 2006 |
Jafri F, El-Shewy HM, Lee MH, Kelly M, Luttrell DK, Luttrell LM. Constitutive ERK1/2 activation by a chimeric neurokinin 1 receptor-beta-arrestin1 fusion protein. Probing the composition and function of the G protein-coupled receptor "signalsome". The Journal of Biological Chemistry. 281: 19346-57. PMID 16670094 DOI: 10.1074/jbc.M512643200 |
0.638 |
|
| 2006 |
Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ. Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. The Journal of Biological Chemistry. 281: 10856-64. PMID 16492667 DOI: 10.1074/Jbc.M513380200 |
0.858 |
|
| 2006 |
Caunt CJ, Finch AR, Sedgley KR, Oakley L, Luttrell LM, McArdle CA. Arrestin-mediated ERK activation by gonadotropin-releasing hormone receptors: receptor-specific activation mechanisms and compartmentalization. The Journal of Biological Chemistry. 281: 2701-10. PMID 16314413 DOI: 10.1074/jbc.M507242200 |
0.587 |
|
| 2005 |
Gesty-Palmer D, El Shewy H, Kohout TA, Luttrell LM. beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts. The Journal of Biological Chemistry. 280: 32157-67. PMID 16027114 DOI: 10.1074/jbc.M507460200 |
0.834 |
|
| 2005 |
Luttrell LM. Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity. Journal of Molecular Neuroscience : Mn. 26: 253-64. PMID 16012199 DOI: 10.1385/JMN:26:2-3:253 |
0.584 |
|
| 2005 |
Maudsley S, Martin B, Luttrell LM. The origins of diversity and specificity in g protein-coupled receptor signaling. The Journal of Pharmacology and Experimental Therapeutics. 314: 485-94. PMID 15805429 DOI: 10.1124/jpet.105.083121 |
0.701 |
|
| 2005 |
Pi M, Oakley RH, Gesty-Palmer D, Cruickshank RD, Spurney RF, Luttrell LM, Quarles LD. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Molecular Endocrinology (Baltimore, Md.). 19: 1078-87. PMID 15637145 DOI: 10.1210/Me.2004-0450 |
0.804 |
|
| 2004 |
Luttrell DK, Luttrell LM. Not so strange bedfellows: G-protein-coupled receptors and Src family kinases. Oncogene. 23: 7969-78. PMID 15489914 DOI: 10.1038/sj.onc.1208162 |
0.539 |
|
| 2004 |
El-Shewy HM, Kelly FL, Barki-Harrington L, Luttrell LM. Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I. Molecular Endocrinology (Baltimore, Md.). 18: 2727-39. PMID 15272055 DOI: 10.1210/me.2004-0174 |
0.462 |
|
| 2004 |
Luttrell LM. 'Location, location, location': activation and targeting of MAP kinases by G protein-coupled receptors. Journal of Molecular Endocrinology. 30: 117-26. PMID 12683936 DOI: 10.1677/Jme.0.0300117 |
0.581 |
|
| 2003 |
Luttrell DK, Luttrell LM. Signaling in time and space: G protein-coupled receptors and mitogen-activated protein kinases. Assay and Drug Development Technologies. 1: 327-38. PMID 15090198 DOI: 10.1089/15406580360545143 |
0.537 |
|
| 2003 |
Barki-Harrington L, Luttrell LM, Rockman HA. Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. Circulation. 108: 1611-8. PMID 12963634 DOI: 10.1161/01.Cir.0000092166.30360.78 |
0.452 |
|
| 2003 |
Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, Luttrell LM, Lefkowitz RJ. Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proceedings of the National Academy of Sciences of the United States of America. 100: 10782-7. PMID 12949261 DOI: 10.1073/Pnas.1834556100 |
0.861 |
|
| 2003 |
Rapacciuolo A, Suvarna S, Barki-Harrington L, Luttrell LM, Cong M, Lefkowitz RJ, Rockman HA. Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. The Journal of Biological Chemistry. 278: 35403-11. PMID 12821660 DOI: 10.1074/Jbc.M305675200 |
0.823 |
|
| 2003 |
Ahmed I, Gesty-Palmer D, Drezner MK, Luttrell LM. Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts. Molecular Endocrinology (Baltimore, Md.). 17: 1607-21. PMID 12738761 DOI: 10.1210/me.2002-0040 |
0.559 |
|
| 2003 |
Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM. The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. The Journal of Biological Chemistry. 278: 6258-67. PMID 12473660 DOI: 10.1074/jbc.M212231200 |
0.855 |
|
| 2002 |
Lefkowitz RJ, Pierce KL, Luttrell LM. Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. Molecular Pharmacology. 62: 971-4. PMID 12391258 DOI: 10.1124/mol.62.5.971 |
0.633 |
|
| 2002 |
Luttrell LM. Big G, little G: G proteins and actin cytoskeletal reorganization. Molecular Cell. 9: 1152-4. PMID 12086610 |
0.434 |
|
| 2002 |
Zamah AM, Delahunty M, Luttrell LM, Lefkowitz RJ. Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. The Journal of Biological Chemistry. 277: 31249-56. PMID 12063255 DOI: 10.1074/jbc.M202753200 |
0.834 |
|
| 2002 |
Luttrell LM. Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors. Canadian Journal of Physiology and Pharmacology. 80: 375-82. PMID 12056542 |
0.512 |
|
| 2002 |
Feldman DS, Zamah AM, Pierce KL, Miller WE, Kelly F, Rapacciuolo A, Rockman HA, Koch WJ, Luttrell LM. Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. The Journal of Biological Chemistry. 277: 28631-40. PMID 12036966 DOI: 10.1074/Jbc.M204753200 |
0.862 |
|
| 2002 |
Ahn S, Kim J, Lucaveche CL, Reedy MC, Luttrell LM, Lefkowitz RJ, Daaka Y. Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. The Journal of Biological Chemistry. 277: 26642-51. PMID 12011079 DOI: 10.1074/Jbc.M201499200 |
0.799 |
|
| 2002 |
Luttrell LM, Lefkowitz RJ. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. Journal of Cell Science. 115: 455-65. PMID 11861753 |
0.744 |
|
| 2002 |
Tohgo A, Pierce KL, Choy EW, Lefkowitz RJ, Luttrell LM. beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. The Journal of Biological Chemistry. 277: 9429-36. PMID 11777902 DOI: 10.1074/jbc.M106457200 |
0.853 |
|
| 2001 |
Imamura T, Huang J, Dalle S, Ugi S, Usui I, Luttrell LM, Miller WE, Lefkowitz RJ, Olefsky JM. beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. The Journal of Biological Chemistry. 276: 43663-7. PMID 11546805 DOI: 10.1074/Jbc.M105364200 |
0.743 |
|
| 2001 |
Grewal JS, Luttrell LM, Raymond JR. G protein-coupled receptors desensitize and down-regulate epidermal growth factor receptors in renal mesangial cells. The Journal of Biological Chemistry. 276: 27335-44. PMID 11371570 DOI: 10.1074/JBC.M103578200 |
0.533 |
|
| 2001 |
Pierce KL, Luttrell LM, Lefkowitz RJ. New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene. 20: 1532-9. PMID 11313899 DOI: 10.1038/sj.onc.1204184 |
0.719 |
|
| 2001 |
Pierce KL, Tohgo A, Ahn S, Field ME, Luttrell LM, Lefkowitz RJ. Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. The Journal of Biological Chemistry. 276: 23155-60. PMID 11290747 DOI: 10.1074/Jbc.M101303200 |
0.841 |
|
| 2001 |
Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME, Pierce KL, Lefkowitz RJ. Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proceedings of the National Academy of Sciences of the United States of America. 98: 2449-54. PMID 11226259 DOI: 10.1073/Pnas.041604898 |
0.81 |
|
| 2000 |
Maudsley S, Zamah AM, Rahman N, Blitzer JT, Luttrell LM, Lefkowitz RJ, Hall RA. Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. Molecular and Cellular Biology. 20: 8352-63. PMID 11046132 DOI: 10.1128/Mcb.20.22.8352-8363.2000 |
0.839 |
|
| 2000 |
Cao W, Luttrell LM, Medvedev AV, Pierce KL, Daniel KW, Dixon TM, Lefkowitz RJ, Collins S. Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. The Journal of Biological Chemistry. 275: 38131-4. PMID 11013230 DOI: 10.1074/Jbc.C000592200 |
0.764 |
|
| 2000 |
Roudabush FL, Pierce KL, Maudsley S, Khan KD, Luttrell LM. Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. The Journal of Biological Chemistry. 275: 22583-9. PMID 10807918 DOI: 10.1074/Jbc.M002915200 |
0.832 |
|
| 2000 |
Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ. beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. The Journal of Biological Chemistry. 275: 11312-9. PMID 10753943 DOI: 10.1074/Jbc.275.15.11312 |
0.847 |
|
| 2000 |
Maudsley S, Pierce KL, Zamah AM, Miller WE, Ahn S, Daaka Y, Lefkowitz RJ, Luttrell LM. The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. The Journal of Biological Chemistry. 275: 9572-80. PMID 10734107 DOI: 10.1074/Jbc.275.13.9572 |
0.864 |
|
| 2000 |
Pierce KL, Maudsley S, Daaka Y, Luttrell LM, Lefkowitz RJ. Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 1489-94. PMID 10677489 DOI: 10.1073/PNAS.97.4.1489 |
0.844 |
|
| 2000 |
Seo B, Choy EW, Maudsley S, Miller WE, Wilson BA, Luttrell LM. Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor. The Journal of Biological Chemistry. 275: 2239-45. PMID 10636931 DOI: 10.1074/Jbc.275.3.2239 |
0.81 |
|
| 1999 |
Price DT, Della Rocca G, Guo C, Ballo MS, Schwinn DA, Luttrell LM. Activation of extracellular signal-regulated kinase in human prostate cancer. The Journal of Urology. 162: 1537-42. PMID 10492251 DOI: 10.1016/S0022-5347(05)68354-1 |
0.567 |
|
| 1999 |
Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ. Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. The Journal of Biological Chemistry. 274: 15971-4. PMID 10347142 DOI: 10.1074/Jbc.274.23.15971 |
0.77 |
|
| 1999 |
Della Rocca GJ, Maudsley S, Daaka Y, Lefkowitz RJ, Luttrell LM. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. The Journal of Biological Chemistry. 274: 13978-84. PMID 10318809 DOI: 10.1074/Jbc.274.20.13978 |
0.848 |
|
| 1999 |
Luttrell LM, Daaka Y, Lefkowitz RJ. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Current Opinion in Cell Biology. 11: 177-83. PMID 10209148 DOI: 10.1016/S0955-0674(99)80023-4 |
0.809 |
|
| 1999 |
Soeder KJ, Snedden SK, Cao W, Della Rocca GJ, Daniel KW, Luttrell LM, Collins S. The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. The Journal of Biological Chemistry. 274: 12017-22. PMID 10207024 DOI: 10.1074/Jbc.274.17.12017 |
0.782 |
|
| 1999 |
Della Rocca GJ, Mukhin YV, Garnovskaya MN, Daaka Y, Clark GJ, Luttrell LM, Lefkowitz RJ, Raymond JR. Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis. The Journal of Biological Chemistry. 274: 4749-53. PMID 9988712 DOI: 10.1074/jbc.274.8.4749 |
0.812 |
|
| 1999 |
Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science (New York, N.Y.). 283: 655-61. PMID 9924018 DOI: 10.1126/Science.283.5402.655 |
0.885 |
|
| 1999 |
Ahn S, Maudsley S, Luttrell LM, Lefkowitz RJ, Daaka Y. Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. The Journal of Biological Chemistry. 274: 1185-8. PMID 9880482 DOI: 10.1074/Jbc.274.3.1185 |
0.887 |
|
| 1998 |
Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science (New York, N.Y.). 280: 574-7. PMID 9554846 DOI: 10.1126/Science.280.5363.574 |
0.823 |
|
| 1998 |
Daaka Y, Luttrell LM, Ahn S, Della Rocca GJ, Ferguson SS, Caron MG, Lefkowitz RJ. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. The Journal of Biological Chemistry. 273: 685-8. PMID 9422717 DOI: 10.1074/Jbc.273.2.685 |
0.875 |
|
| 1998 |
Luttrell LM, van Biesen T, Hawes BE, Della Rocca GJ, Luttrell DK, Lefkowitz RJ. Regulation of mitogen-activated protein kinase pathways by catecholamine receptors. Advances in Pharmacology (San Diego, Calif.). 42: 466-70. PMID 9327940 DOI: 10.1016/S1054-3589(08)60789-9 |
0.679 |
|
| 1997 |
Luttrell LM, Daaka Y, Della Rocca GJ, Lefkowitz RJ. G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. The Journal of Biological Chemistry. 272: 31648-56. PMID 9395506 DOI: 10.1074/Jbc.272.50.31648 |
0.796 |
|
| 1997 |
Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 390: 88-91. PMID 9363896 DOI: 10.1038/36362 |
0.848 |
|
| 1997 |
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. The Journal of Biological Chemistry. 272: 19125-32. PMID 9235901 DOI: 10.1074/jbc.272.31.19125 |
0.812 |
|
| 1997 |
Luttrell LM, Della Rocca GJ, van Biesen T, Luttrell DK, Lefkowitz RJ. Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. The Journal of Biological Chemistry. 272: 4637-44. PMID 9020193 DOI: 10.1074/jbc.272.7.4637 |
0.711 |
|
| 1996 |
van Biesen T, Luttrell LM, Hawes BE, Lefkowitz RJ. Mitogenic signaling via G protein-coupled receptors. Endocrine Reviews. 17: 698-714. PMID 8969974 DOI: 10.1210/Edrv-17-6-698 |
0.83 |
|
| 1996 |
Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. The Journal of Biological Chemistry. 271: 19443-50. PMID 8702633 DOI: 10.1074/jbc.271.32.19443 |
0.646 |
|
| 1996 |
Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ. Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. The Journal of Biological Chemistry. 271: 12133-6. PMID 8647803 DOI: 10.1074/jbc.271.21.12133 |
0.657 |
|
| 1996 |
van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ. G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. The Journal of Biological Chemistry. 271: 1266-9. PMID 8576109 DOI: 10.1074/jbc.271.3.1266 |
0.752 |
|
| 1995 |
Luttrell LM, Hawes BE, Touhara K, van Biesen T, Koch WJ, Lefkowitz RJ. Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. The Journal of Biological Chemistry. 270: 12984-9. PMID 7768889 DOI: 10.1074/JBC.270.22.12984 |
0.771 |
|
| 1995 |
van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ. Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature. 376: 781-4. PMID 7651538 DOI: 10.1038/376781a0 |
0.794 |
|
| 1995 |
Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. The Journal of Biological Chemistry. 270: 16495-8. PMID 7622449 DOI: 10.1074/JBC.270.28.16495 |
0.835 |
|
| 1995 |
Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ. Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. The Journal of Biological Chemistry. 270: 17148-53. PMID 7615510 DOI: 10.1074/JBC.270.29.17148 |
0.768 |
|
| 1994 |
Inglese J, Luttrell LM, Iñiguez-Lluhi JA, Touhara K, Koch WJ, Lefkowitz RJ. Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 91: 3637-41. PMID 8170960 DOI: 10.1073/PNAS.91.9.3637 |
0.793 |
|
| 1993 |
Luttrell LM, Ostrowski J, Cotecchia S, Kendall H, Lefkowitz RJ. Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. Science (New York, N.Y.). 259: 1453-7. PMID 8383880 DOI: 10.1126/SCIENCE.8383880 |
0.764 |
|
| 1988 |
Luttrell DK, Luttrell LM, Parsons SJ. Augmented mitogenic responsiveness to epidermal growth factor in murine fibroblasts that overexpress pp60c-src Molecular and Cellular Biology. 8: 497-501. PMID 2447487 DOI: 10.1128/Mcb.8.1.497 |
0.314 |
|
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