Xiao Xiao, PhD - Publications

Affiliations: 
University of North Carolina, Chapel Hill, Chapel Hill, NC 

166 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Chu X, Li J, Qiao C, Wang J, Wang Y, Jiang XC, You H, Xiao X, Wang B. Long-term effect of human mini-dystrophin in transgenic mdx mice improves muscle physiological function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21628. PMID 33982338 DOI: 10.1096/fj.202100057RR  0.334
2019 Jin Q, Qiao C, Li J, Li J, Xiao X. An engineered serum albumin-binding AAV9 capsid achieves improved liver transduction after intravenous delivery in mice. Gene Therapy. PMID 31819202 DOI: 10.1038/S41434-019-0107-2  0.371
2019 Jin Q, Qiao C, Li J, Xiao B, Li J, Xiao X. A GDF11/myostatin inhibitor, GDF11 propeptide-Fc, increases skeletal muscle mass and improves muscle strength in dystrophic mdx mice. Skeletal Muscle. 9: 16. PMID 31133057 DOI: 10.1186/S13395-019-0197-Y  0.365
2018 Yan H, Meng J, Zhang S, Zhuang H, Song Y, Xiao X, Wang DW, Jiang J. Pretreatment of rAAV-Mediated Expression of Myostatin Propeptide Lowers Type 2 Diabetes Incidence in C57BL/6 Mice on High-fat Diet. Human Gene Therapy. PMID 30526118 DOI: 10.1089/Hum.2018.140  0.304
2018 Bulaklak K, Xiao B, Qiao C, Li J, Patel T, Jin Q, Li J, Xiao X. MicroRNA-206 Downregulation Improves Therapeutic Gene Expression and Motor Function in mdx Mice. Molecular Therapy. Nucleic Acids. 12: 283-293. PMID 30195767 DOI: 10.1016/J.Omtn.2018.05.011  0.422
2018 Xiao W, Gao G, Ling C, Herzog RW, Xiao X, Samulski RJ. Impact of neutralizing antibodies against AAV is a key consideration in gene transfer to nonhuman primates. Nature Medicine. PMID 29867233 DOI: 10.1038/S41591-018-0062-2  0.456
2018 Tucker JD, Lu PJ, Xiao X, Lu QL. Overexpression of Mutant FKRP Restores Functional Glycosylation and Improves Dystrophic Phenotype in FKRP Mutant Mice. Molecular Therapy. Nucleic Acids. 11: 216-227. PMID 29858056 DOI: 10.1016/J.Omtn.2018.02.008  0.359
2018 Qiao C, Dai Y, Nikolova VD, Jin Q, Li J, Xiao B, Li J, Moy SS, Xiao X. Amelioration of Muscle and Nerve Pathology in LAMA2 Muscular Dystrophy by AAV9-Mini-Agrin. Molecular Therapy. Methods & Clinical Development. 9: 47-56. PMID 29766020 DOI: 10.1016/J.Omtm.2018.01.005  0.412
2018 Jin Q, Qiao C, Li J, Li J, Xiao X. Neonatal Systemic AAV-Mediated Gene Delivery of GDF11 Inhibits Skeletal Muscle Growth. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29503194 DOI: 10.1016/J.Ymthe.2018.01.016  0.379
2017 Sun J, Yuan Z, Abajas YL, Szollosi DE, Hu G, Hua B, Xiao X, Li C. A retrospective study of cytokine profiles changes in mice with FVIII inhibitor development after AAV mediated gene therapy in hemophilia A mouse model. Human Gene Therapy. PMID 28922951 DOI: 10.1089/Hum.2017.094  0.373
2017 Zheng H, Qiao C, Tang R, Li J, Bulaklak K, Huang Z, Zhao C, Dai Y, Li J, Xiao X. Follistatin N terminus differentially regulates muscle size and fat in vivo. Experimental & Molecular Medicine. 49: e377. PMID 28912572 DOI: 10.1038/Emm.2017.135  0.359
2017 Bulaklak K, Xiao X. Therapeutic advances in musculoskeletal AAV targeting approaches. Current Opinion in Pharmacology. 34: 56-63. PMID 28743034 DOI: 10.1016/J.Coph.2017.07.001  0.429
2017 Vannoy CH, Xiao W, Lu P, Xiao X, Lu QL. Efficacy of Gene Therapy Is Dependent on Disease Progression in Dystrophic Mice with Mutations in the FKRP Gene. Molecular Therapy. Methods & Clinical Development. 5: 31-42. PMID 28480302 DOI: 10.1016/J.Omtm.2017.02.002  0.429
2017 Yin C, Zhang T, Qu X, Zhang Y, Putatunda R, Xiao X, Li F, Xiao W, Zhao H, Dai S, Qin X, Mo X, Young WB, Khalili K, Hu W. In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28366764 DOI: 10.1016/J.Ymthe.2017.03.012  0.383
2017 Vannoy CH, Zhou H, Qiao C, Xiao X, Bang AG, Lu QL. Adeno-Associated Virus-Mediated Mini-Agrin Delivery Is Unable to Rescue Disease Phenotype in a Mouse Model of Limb Girdle Muscular Dystrophy Type 2I. The American Journal of Pathology. 187: 431-440. PMID 28107841 DOI: 10.1016/J.Ajpath.2016.09.024  0.359
2016 Jiang J, Shen G, Li J, Qiao C, Xiao B, Yan H, Wang DW, Xiao X. Adeno-associated virus-mediated expression of myostatin propeptide improves the growth of skeletal muscle and attenuates hyperglycemia in db/db mice. Gene Therapy. PMID 27983718 DOI: 10.1038/Gt.2016.85  0.379
2016 Li J, Komegay J, Qiao C, Zheng H, Li J, Tang R, Dai Y, Xiao X. 721. Long-Term (2-8 years) Body-Wide Expression of AAV9-Minidystrophin Gene in Golden Retriever Muscular Dystrophy Dogs After Regional Limb Vein Injection Molecular Therapy. 24: S284. DOI: 10.1016/S1525-0016(16)33529-8  0.442
2015 Ling C, Wang Y, Lu Y, Wang L, Jayandharan GR, Aslanidi GV, Li B, Cheng B, Ma W, Lentz T, Ling C, Xiao X, Samulski RJ, Muzyczka N, Srivastava A. The Adeno-Associated Virus Genome Packaging Puzzle. Journal of Molecular and Genetic Medicine : An International Journal of Biomedical Research. 9. PMID 26949410 DOI: 10.4172/1747-0862.1000175  0.538
2015 He B, Cruz-Topete D, Oakley RH, Xiao X, Cidlowski JA. Human Glucocorticoid Receptor β (hGRβ) Regulates Gluconeogenesis and Inflammation in Mouse Liver. Molecular and Cellular Biology. PMID 26711253 DOI: 10.1128/Mcb.00908-15  0.302
2015 Berns KI, Byrne BJ, Flotte TR, Gao G, Hauswirth WW, Herzog RW, Muzyczka N, VandenDriessche T, Xiao X, Zolotukhin S, Srivastava A. Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma? Human Gene Therapy. 26: 779-81. PMID 26690810 DOI: 10.1089/Hum.2015.29014.Kib  0.627
2015 Ling C, Wang Y, Lu Y, Wang L, Jayandharan GR, Aslanidi GV, Li B, Cheng B, Ma W, Lentz T, Ling C, Xiao X, Samulski RJ, Muzyczka N, Srivastava A. Enhanced transgene expression from recombinant single-stranded D-sequence-substituted adeno-associated virus vectors in human cell lines in vitro and in murine hepatocytes in vivo. Journal of Virology. 89: 952-61. PMID 25355884 DOI: 10.1128/Jvi.02581-14  0.581
2015 Xiao B, Yuan Z, Yang L, Qiao C, Li J, Li J, Xiao X. 603. Novel DNA-Shuffled AAV Capsids Show Robust and Unique Gene Delivery and Expression Profiles in the CNS Via Intrathecal Injection Molecular Therapy. 23: S239-S240. DOI: 10.1016/S1525-0016(16)34212-5  0.397
2015 Qiao C, Dai Y, Nikolova V, Li J, Li J, Moy S, Xiao X. 507. AAV-Mini-Agrin for Laminin-alpha2 Deficient CMD Molecular Therapy. 23: S203. DOI: 10.1016/S1525-0016(16)34116-8  0.386
2015 Tremblay JP, Gérard C, Xiao X, Filali M, Coulombe Z, Arsenault M, Couet J, Li J, Drolet M, Chapdelaine P, Chikh A. 384. AAV9 -Frataxin Reduces the Symptoms and Prolongs the Life of Friedreich Ataxia Mouse Models Molecular Therapy. 23: S153. DOI: 10.1016/S1525-0016(16)33993-4  0.374
2015 Martin CB, Mayer C, Qiao C, Yuan Z, Yang L, Li J, Li J, Xiao X. 317. HH67.2, a Promising Novel Adeno-Associated Virus (AAV) Vector, Shows Improved Muscle Specificity and Infectivity Compared To AAV9 Molecular Therapy. 23: S128. DOI: 10.1016/S1525-0016(16)33926-0  0.453
2015 Xiao B, Zheng P, Yuan Z, Qiao C, Li J, Xiao X. 102. AAV9 Exclusively Targets the Juxtaglomerular Apparatus in the Adult Mouse Kidney After Intravenous Injection Molecular Therapy. 23: S43. DOI: 10.1016/S1525-0016(16)33707-8  0.323
2014 Gérard C, Xiao X, Filali M, Coulombe Z, Arsenault M, Couet J, Li J, Drolet MC, Chapdelaine P, Chikh A, Tremblay JP. An AAV9 coding for frataxin clearly improved the symptoms and prolonged the life of Friedreich ataxia mouse models. Molecular Therapy. Methods & Clinical Development. 1: 14044. PMID 26015982 DOI: 10.1038/Mtm.2014.44  0.393
2014 Qiao C, Wang CH, Zhao C, Lu P, Awano H, Xiao B, Li J, Yuan Z, Dai Y, Martin CB, Li J, Lu Q, Xiao X. Muscle and heart function restoration in a limb girdle muscular dystrophy 2I (LGMD2I) mouse model by systemic FKRP gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1890-9. PMID 25048216 DOI: 10.1038/Mt.2014.141  0.43
2014 Lenhart KC, Becherer AL, Li J, Xiao X, McNally EM, Mack CP, Taylor JM. GRAF1 promotes ferlin-dependent myoblast fusion. Developmental Biology. 393: 298-311. PMID 25019370 DOI: 10.1016/J.Ydbio.2014.06.025  0.331
2014 Vannoy CH, Xu L, Keramaris E, Lu P, Xiao X, Lu QL. Adeno-associated virus-mediated overexpression of LARGE rescues α-dystroglycan function in dystrophic mice with mutations in the fukutin-related protein. Human Gene Therapy Methods. 25: 187-96. PMID 24635668 DOI: 10.1089/Hgtb.2013.151  0.405
2014 Ma HI, Hueng DY, Shui HA, Han JM, Wang CH, Lai YH, Cheng SY, Xiao X, Chen MT, Yang YP. Intratumoral decorin gene delivery by AAV vector inhibits brain glioblastomas and prolongs survival of animals by inducing cell differentiation. International Journal of Molecular Sciences. 15: 4393-414. PMID 24625664 DOI: 10.3390/Ijms15034393  0.381
2014 Qiao C, Li C, Zhao C, Li J, Bian T, Grieger J, Li J, Samulski RJ, Xiao X. K137R mutation on adeno-associated viral capsids had minimal effect on enhancing gene delivery in vivo. Human Gene Therapy Methods. 25: 33-9. PMID 24116972 DOI: 10.1089/Hgtb.2013.176  0.46
2013 Xu L, Lu PJ, Wang CH, Keramaris E, Qiao C, Xiao B, Blake DJ, Xiao X, Lu QL. Adeno-associated virus 9 mediated FKRP gene therapy restores functional glycosylation of α-dystroglycan and improves muscle functions. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1832-40. PMID 23817215 DOI: 10.1038/Mt.2013.156  0.455
2013 Blaeser A, Keramaris E, Chan YM, Sparks S, Cowley D, Xiao X, Lu QL. Mouse models of fukutin-related protein mutations show a wide range of disease phenotypes. Human Genetics. 132: 923-34. PMID 23591631 DOI: 10.1007/S00439-013-1302-7  0.322
2013 Lee HH, O'Malley MJ, Friel NA, Payne KA, Qiao C, Xiao X, Chu CR. Persistence, localization, and external control of transgene expression after single injection of adeno-associated virus into injured joints. Human Gene Therapy. 24: 457-66. PMID 23496155 DOI: 10.1089/Hum.2012.118  0.339
2013 Yang L, Xiao X. Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution. Virology Journal. 10: 50. PMID 23394344 DOI: 10.1186/1743-422X-10-50  0.438
2013 Tremblay JP, Xiao X, Aartsma-Rus A, Barbas C, Blau HM, Bogdanove AJ, Boycott K, Braun S, Breakefield XO, Bueren JA, Buschmann M, Byrne BJ, Calos M, Cathomen T, Chamberlain J, et al. Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 266-8. PMID 23369965 DOI: 10.1038/Mt.2013.4  0.699
2013 Qiao C, Yuan Z, Li J, Tang R, Li J, Xiao X. Single tyrosine mutation in AAV8 and AAV9 capsids is insufficient to enhance gene delivery to skeletal muscle and heart. Human Gene Therapy Methods. 23: 29-37. PMID 22428978 DOI: 10.1089/Hgtb.2011.229  0.462
2012 He B, Tang RH, Weisleder N, Xiao B, Yuan Z, Cai C, Zhu H, Lin P, Qiao C, Li J, Mayer C, Li J, Ma J, Xiao X. Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 727-35. PMID 22314291 DOI: 10.1038/Mt.2012.5  0.376
2012 Kornegay JN, Bogan JR, Bogan DJ, Childers MK, Li J, Nghiem P, Detwiler DA, Larsen CA, Grange RW, Bhavaraju-Sanka RK, Tou S, Keene BP, Howard JF, Wang J, Fan Z, ... Xiao X, et al. Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 85-108. PMID 22218699 DOI: 10.1007/S00335-011-9382-Y  0.385
2012 Bowles DE, McPhee SW, Li C, Gray SJ, Samulski JJ, Camp AS, Li J, Wang B, Monahan PE, Rabinowitz JE, Grieger JC, Govindasamy L, Agbandje-McKenna M, Xiao X, Samulski RJ. Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 443-55. PMID 22068425 DOI: 10.1038/Mt.2011.237  0.696
2011 Qiao C, Koo T, Li J, Xiao X, Dickson JG. Gene therapy in skeletal muscle mediated by adeno-associated virus vectors Methods in Molecular Biology. 807: 119-140. PMID 22034028 DOI: 10.1007/978-1-61779-370-7_5  0.474
2011 Payne KA, Lee HH, Haleem AM, Martins C, Yuan Z, Qiao C, Xiao X, Chu CR. Single intra-articular injection of adeno-associated virus results in stable and controllable in vivo transgene expression in normal rat knees. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 19: 1058-65. PMID 21571082 DOI: 10.1016/J.Joca.2011.04.009  0.385
2011 Pichavant C, Aartsma-Rus A, Clemens PR, Davies KE, Dickson G, Takeda S, Wilton SD, Wolff JA, Wooddell CI, Xiao X, Tremblay JP. Current status of pharmaceutical and genetic therapeutic approaches to treat DMD. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 830-40. PMID 21468001 DOI: 10.1038/Mt.2011.59  0.43
2011 Lee HH, Haleem AM, Yao V, Li J, Xiao X, Chu CR. Release of bioactive adeno-associated virus from fibrin scaffolds: effects of fibrin glue concentrations. Tissue Engineering. Part A. 17: 1969-78. PMID 21449684 DOI: 10.1089/Ten.Tea.2010.0586  0.325
2011 Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes & Development. 25: 263-74. PMID 21289070 DOI: 10.1101/Gad.2018511  0.327
2011 Wang CH, Chan YM, Tang RH, Xiao B, Lu P, Keramaris-Vrantsis E, Zheng H, Qiao C, Jiang J, Li J, Ma HI, Lu Q, Xiao X. Post-Natal knockdown of fukutin-related protein expression in muscle by long-termRNA interference induces dystrophic pathology [corrected]. The American Journal of Pathology. 178: 261-72. PMID 21224063 DOI: 10.1016/J.Ajpath.2010.11.020  0.464
2011 Yang L, Li J, Xiao X. Directed evolution of adeno-associated virus (AAV) as vector for muscle gene therapy. Methods in Molecular Biology (Clifton, N.J.). 709: 127-39. PMID 21194025 DOI: 10.1007/978-1-61737-982-6_8  0.47
2011 Yuan Z, Qiao C, Hu P, Li J, Xiao X. A versatile adeno-associated virus vector producer cell line method for scalable vector production of different serotypes. Human Gene Therapy. 22: 613-24. PMID 21186998 DOI: 10.1089/Hum.2010.241  0.372
2011 Wu B, Xiao B, Cloer C, Shaban M, Sali A, Lu P, Li J, Nagaraju K, Xiao X, Lu QL. One-year treatment of morpholino antisense oligomer improves skeletal and cardiac muscle functions in dystrophic mdx mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 576-83. PMID 21179007 DOI: 10.1038/Mt.2010.288  0.384
2011 Qiao C, Yuan Z, Li J, He B, Zheng H, Mayer C, Li J, Xiao X. Liver-specific microRNA-122 target sequences incorporated in AAV vectors efficiently inhibits transgene expression in the liver. Gene Therapy. 18: 403-10. PMID 21150938 DOI: 10.1038/Gt.2010.157  0.339
2011 Hoshijima M, Hayashi T, Jeon YE, Fu Z, Gu Y, Dalton ND, Ellisman MH, Xiao X, Powell FL, Ross J. Delta-sarcoglycan gene therapy halts progression of cardiac dysfunction, improves respiratory failure, and prolongs life in myopathic hamsters. Circulation. Heart Failure. 4: 89-97. PMID 21036890 DOI: 10.1161/Circheartfailure.110.957258  0.361
2010 Xiao X. Adeno-associated viral vectors found free in media Human Gene Therapy. 21: 1221-1222. PMID 20942751 DOI: 10.1089/Hum.2010.921  0.33
2010 Mendell JR, Campbell K, Rodino-Klapac L, Sahenk Z, Shilling C, Lewis S, Bowles D, Gray S, Li C, Galloway G, Malik V, Coley B, Clark KR, Li J, Xiao X, et al. Dystrophin immunity in Duchenne's muscular dystrophy. The New England Journal of Medicine. 363: 1429-37. PMID 20925545 DOI: 10.1056/Nejmoa1000228  0.681
2010 Koppanati BM, Li J, Reay DP, Wang B, Daood M, Zheng H, Xiao X, Watchko JF, Clemens PR. Improvement of the mdx mouse dystrophic phenotype by systemic in utero AAV8 delivery of a minidystrophin gene. Gene Therapy. 17: 1355-62. PMID 20535217 DOI: 10.1038/Gt.2010.84  0.426
2010 Kornegay JN, Li J, Bogan JR, Bogan DJ, Chen C, Zheng H, Wang B, Qiao C, Howard JF, Xiao X. Widespread muscle expression of an AAV9 human mini-dystrophin vector after intravenous injection in neonatal dystrophin-deficient dogs. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1501-8. PMID 20517298 DOI: 10.1038/Mt.2010.94  0.432
2010 Qiao C, Zhang W, Yuan Z, Shin JH, Li J, Jayandharan GR, Zhong L, Srivastava A, Xiao X, Duan D. Adeno-associated virus serotype 6 capsid tyrosine-to-phenylalanine mutations improve gene transfer to skeletal muscle. Human Gene Therapy. 21: 1343-8. PMID 20497037 DOI: 10.1089/Hum.2010.003  0.483
2010 Pichavant C, Chapdelaine P, Cerri DG, Dominique JC, Quenneville SP, Skuk D, Kornegay JN, Bizario JC, Xiao X, Tremblay JP. Expression of dog microdystrophin in mouse and dog muscles by gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1002-9. PMID 20179674 DOI: 10.1038/Mt.2010.23  0.418
2010 Zheng H, Qiao C, Wang CH, Li J, Li J, Yuan Z, Zhang C, Xiao X. Efficient retrograde transport of adeno-associated virus type 8 to spinal cord and dorsal root ganglion after vector delivery in muscle. Human Gene Therapy. 21: 87-97. PMID 19719401 DOI: 10.1089/Hum.2009.131  0.367
2010 Zhou L, Zhu T, Ye X, Yang L, Wang B, Liang X, Lu L, Tsao YP, Chen SL, Li J, Xiao X. Long-term protection against human papillomavirus e7-positive tumor by a single vaccination of adeno-associated virus vectors encoding a fusion protein of inactivated e7 of human papillomavirus 16/18 and heat shock protein 70. Human Gene Therapy. 21: 109-19. PMID 19715402 DOI: 10.1089/Hum.2009.139  0.332
2010 Qiao C, Li J, Zheng H, Bogan J, Li J, Yuan Z, Zhang C, Bogan D, Kornegay J, Xiao X. Hydrodynamic limb vein injection of adeno-associated virus serotype 8 vector carrying canine myostatin propeptide gene into normal dogs enhances muscle growth. Human Gene Therapy. 20: 1-10. PMID 18828709 DOI: 10.1089/Hum.2008.135  0.439
2010 Payne K, Lee H, Haleem A, Martin C, Xiao X, Chu C. 030 SINGLE INTRA-ARTICULAR INJECTION RESULTS IN STABLE AND CONTROLLABLE IN VIVO TRANSGENE EXPRESSION Osteoarthritis and Cartilage. 18: S22. DOI: 10.1016/S1063-4584(10)60057-X  0.314
2010 Qiao C, Xiao X. Muscular dystrophy gene therapy in small animal models Muscle Gene Therapy. 55-68. DOI: 10.1007/978-1-4419-1207-7_4  0.354
2009 Yan W, Wang P, Zhao CX, Tang J, Xiao X, Wang DW. Decorin gene delivery inhibits cardiac fibrosis in spontaneously hypertensive rats by modulation of transforming growth factor-beta/Smad and p38 mitogen-activated protein kinase signaling pathways. Human Gene Therapy. 20: 1190-200. PMID 19697998 DOI: 10.1089/Hum.2008.204  0.339
2009 Yu CY, Yuan Z, Cao Z, Wang B, Qiao C, Li J, Xiao X. A muscle-targeting peptide displayed on AAV2 improves muscle tropism on systemic delivery. Gene Therapy. 16: 953-62. PMID 19474807 DOI: 10.1038/Gt.2009.59  0.385
2009 Koppanati BM, Li J, Xiao X, Clemens PR. Systemic delivery of AAV8 in utero results in gene expression in diaphragm and limb muscle: treatment implications for muscle disorders. Gene Therapy. 16: 1130-7. PMID 19474806 DOI: 10.1038/Gt.2009.71  0.431
2009 Yang L, Jiang J, Drouin LM, Agbandje-McKenna M, Chen C, Qiao C, Pu D, Hu X, Wang DZ, Li J, Xiao X. A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection. Proceedings of the National Academy of Sciences of the United States of America. 106: 3946-51. PMID 19234115 DOI: 10.1073/Pnas.0813207106  0.463
2009 Méjat A, Decostre V, Li J, Renou L, Kesari A, Hantaï D, Stewart CL, Xiao X, Hoffman E, Bonne G, Misteli T. Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. The Journal of Cell Biology. 184: 31-44. PMID 19124654 DOI: 10.1083/Jcb.200811035  0.315
2009 Chen CC, Sun CP, Ma HI, Fang CC, Wu PY, Xiao X, Tao MH. Comparative study of anti-hepatitis B virus RNA interference by double-stranded adeno-associated virus serotypes 7, 8, and 9. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 352-9. PMID 19066602 DOI: 10.1038/Mt.2008.245  0.341
2009 Wang B, Li J, Fu FH, Xiao X. Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 27: 421-6. PMID 18973234 DOI: 10.1002/Jor.20781  0.431
2009 Wang T, Hou LB, Liu ZJ, Wang Y, Chen CL, Xiao X, Wang DW. Intramuscular delivery of rAAV-mediated kallikrein gene reduces hypertension and prevents cardiovascular injuries in model rats. Acta Pharmacologica Sinica. 28: 1898-906. PMID 18031602 DOI: 10.1111/J.1745-7254.2007.00677.X  0.341
2008 Pan T, Cai M, Tang L, Zhou LQ, Li BJ, Zhu T, Li HZ, Li SY, Xiao X, Chen ZS. A novel approach of prophylaxis to HBV recurrence after liver transplantation. Virology. 382: 1-9. PMID 18945464 DOI: 10.1016/J.Virol.2008.06.024  0.303
2008 Wu B, Moulton HM, Iversen PL, Jiang J, Li J, Li J, Spurney CF, Sali A, Guerron AD, Nagaraju K, Doran T, Lu P, Xiao X, Lu QL. Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer. Proceedings of the National Academy of Sciences of the United States of America. 105: 14814-9. PMID 18806224 DOI: 10.1073/Pnas.0805676105  0.376
2008 Li J, Sun W, Wang B, Xiao X, Liu XQ. Protein trans-splicing as a means for viral vector-mediated in vivo gene therapy. Human Gene Therapy. 19: 958-964. PMID 18788906 DOI: 10.1089/Hum.2008.009  0.449
2008 Wang B, Li J, Fu FH, Chen C, Zhu X, Zhou L, Jiang X, Xiao X. Construction and analysis of compact muscle-specific promoters for AAV vectors Gene Therapy. 15: 1489-1499. PMID 18563184 DOI: 10.1038/Gt.2008.104  0.402
2008 Rehman KK, Trucco M, Wang Z, Xiao X, Robbins PD. AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1409-16. PMID 18560422 DOI: 10.1038/Mt.2008.116  0.351
2008 Levicoff EA, Kim JS, Sobajima S, Wallach CJ, Larson JW, Robbins PD, Xiao X, Juan L, Vadala G, Gilbertson LG, Kang JD. Safety assessment of intradiscal gene therapy II: effect of dosing and vector choice. Spine. 33: 1509-16; discussion . PMID 18520636 DOI: 10.1097/Brs.0B013E318178866C  0.407
2008 Wang B, Li J, Qiao C, Chen C, Hu P, Zhu X, Zhou L, Bogan J, Kornegay J, Xiao X. A canine minidystrophin is functional and therapeutic in mdx mice. Gene Therapy. 15: 1099-106. PMID 18432277 DOI: 10.1038/Gt.2008.70  0.433
2008 Qiao C, Li J, Jiang J, Zhu X, Wang B, Li J, Xiao X. Myostatin Propeptide Gene Delivery by Adeno-Associated Virus Serotype 8 Vectors Enhances Muscle Growth and Ameliorates Dystrophic Phenotypes in mdx Mice Human Gene Therapy. 19: 241-253. PMID 18288893 DOI: 10.1089/Hum.2007.159  0.429
2008 Zhou X, Zeng X, Fan Z, Li C, McCown T, Samulski RJ, Xiao X. Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 494-9. PMID 18180769 DOI: 10.1038/Sj.Mt.6300397  0.387
2008 Zhong L, Zhou X, Li Y, Qing K, Xiao X, Samulski RJ, Srivastava A. Single-polarity recombinant adeno-associated virus 2 vector-mediated transgene expression in vitro and in vivo: mechanism of transduction. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 290-5. PMID 18087261 DOI: 10.1038/Sj.Mt.6300376  0.378
2008 Qiao C, Li J, Zheng H, Bogan J, Li J, Yuan Z, Zhang C, Bogan D, Kornegay J, Xiao X. Hydrodynamic limb vein injection of AAV8 canine myostatin propeptide gene in normal dogs enhances muscle growth Human Gene Therapy. 81015093227032. DOI: 10.1089/Hgt.2008.135  0.383
2007 McTiernan CF, Mathier MA, Zhu X, Xiao X, Klein E, Swan CH, Mehdi H, Gibson G, Trichel AM, Glorioso JC, Feldman AM, McCurry KR, London B. Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts. Gene Therapy. 14: 1613-22. PMID 17851548 DOI: 10.1038/Sj.Gt.3303020  0.382
2007 Chen L, Zhu F, Li J, Lu H, Jiang H, Sarkar R, Arruda VR, Wang J, Zhao J, Pierce GF, Ding Q, Wang X, Wang H, Pipe SW, Liu XQ, Xiao X, et al. The enhancing effects of the light chain on heavy chain secretion in split delivery of factor VIII gene. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1856-62. PMID 17653101 DOI: 10.1038/Sj.Mt.6300268  0.481
2007 Jiang JG, Ning YG, Chen C, Ma D, Liu ZJ, Yang S, Zhou J, Xiao X, Zhang XA, Edin ML, Card JW, Wang J, Zeldin DC, Wang DW. Cytochrome p450 epoxygenase promotes human cancer metastasis. Cancer Research. 67: 6665-74. PMID 17638876 DOI: 10.1158/0008-5472.Can-06-3643  0.307
2007 Li Y, Li J, Zhu J, Sun B, Branca M, Tang Y, Foster W, Xiao X, Huard J. Decorin gene transfer promotes muscle cell differentiation and muscle regeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1616-22. PMID 17609657 DOI: 10.1038/Sj.Mt.6300250  0.374
2007 Lai LJ, Xiao X, Wu JH. Inhibition of corneal neovascularization with endostatin delivered by adeno-associated viral (AAV) vector in a mouse corneal injury model. Journal of Biomedical Science. 14: 313-22. PMID 17373573 DOI: 10.1007/s11373-007-9153-7  0.306
2007 Pagnotto MR, Wang Z, Karpie JC, Ferretti M, Xiao X, Chu CR. Adeno-associated viral gene transfer of transforming growth factor- β 1 to human mesenchymal stem cells improves cartilage repair Gene Therapy. 14: 804-813. PMID 17344902 DOI: 10.1038/Sj.Gt.3302938  0.32
2007 Quenneville SP, Chapdelaine P, Skuk D, Paradis M, Goulet M, Rousseau J, Xiao X, Garcia L, Tremblay JP. Autologous transplantation of muscle precursor cells modified with a lentivirus for muscular dystrophy: human cells and primate models. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 431-8. PMID 17235323 DOI: 10.1038/Sj.Mt.6300047  0.412
2007 Chen CC, Ko TM, Ma HI, Wu HL, Xiao X, Li J, Chang CM, Wu PY, Chen CH, Han JM, Yu CP, Jeng KS, Hu CP, Tao MH. Long-term inhibition of hepatitis B virus in transgenic mice by double-stranded adeno-associated virus 8-delivered short hairpin RNA. Gene Therapy. 14: 11-9. PMID 16929350 DOI: 10.1038/Sj.Gt.3302846  0.369
2006 Tsai TH, Chen SL, Xiao X, Chiang YH, Tsao YP. Gene therapy of focal cerebral ischemia using defective recombinant adeno-associated virus vectors. Frontiers in Bioscience. 11: 2061-2070. PMID 16720292 DOI: 10.2741/1948  0.343
2006 Wang Z, Zhu T, Rehman KK, Bertera S, Zhang J, Chen C, Papworth G, Watkins S, Trucco M, Robbins PD, Li J, Xiao X. Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes. 55: 875-84. PMID 16567506 DOI: 10.2337/Diabetes.55.04.06.Db05-0927  0.426
2006 Draviam RA, Wang B, Li J, Xiao X, Watkins SC. Mini-dystrophin efficiently incorporates into the dystrophin protein complex in living cells. Journal of Muscle Research and Cell Motility. 27: 53-67. PMID 16496225 DOI: 10.1007/S10974-006-9055-8  0.336
2006 Chen L, Li J, Lu H, Jiang H, Sarkar R, Wang J, Arruda V, Pierce G, Pipe S, Liu P, Xiao X, Camire R, Xiao W. An Essential Role of the Factor VIII Light Chain in Facilitating Heavy Chain Secretion. Blood. 108: 4034-4034. DOI: 10.1182/Blood.V108.11.4034.4034  0.433
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2006 Koppanati BM, Li J, Wang B, Xiao X, Clemens PR. 567. Adeno-Associated Virus Vector 8 (AAV8) Provides Efficient Gene Delivery to Skeletal Muscles In Utero by Systemic Adminstration Molecular Therapy. 13: S218. DOI: 10.1016/J.Ymthe.2006.08.640  0.456
2006 Yu C, Wang B, Wang Z, Cao Z, Li J, Xiao X. 486. Efficient and Selective Gene Transfer Directed to Muscle by Tropism-Modified Adeno- Associated Virus Vector Molecular Therapy. 13: S188-S189. DOI: 10.1016/J.Ymthe.2006.08.556  0.458
2006 Hsu EC, Pownall S, Kieffer TJ, Luu Y, Leong S, Robbins PD, Xiao X, Cheung AT. 480. Gene Transfer to Gut K Cells for Physiologic Insulin Replacement in Diabetes Molecular Therapy. 13. DOI: 10.1016/J.Ymthe.2006.08.549  0.377
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2006 Qiao C, Li J, Zhu T, Wang B, Li J, Xiao X. 246. Efficient Gene Transfer to Peripheral Nervous System Via Systemic Delivery of AAV Vectors Molecular Therapy. 13: S95. DOI: 10.1016/J.Ymthe.2006.08.273  0.375
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2006 Wang B, Li J, Chen C, Jiang X, O'Day T, Watchko J, Xiao X. 37. Long-Term Expression of Mini-Human Dystrophin in Transgenic mdx Mice Improves Dystrophic Muscle Functions Molecular Therapy. 13: S16. DOI: 10.1016/J.Ymthe.2006.08.050  0.392
2005 Ye X, Zhu T, Bastacky S, McHale T, Li J, Xiao X. Prevention and reversal of lupus in NZB/NZW mice by costimulatory blockade with adeno-associated virus-mediated gene transfer. Arthritis and Rheumatism. 52: 3975-86. PMID 16329128 DOI: 10.1002/Art.21417  0.425
2005 Zhu T, Zhou L, Mori S, Wang Z, McTiernan CF, Qiao C, Chen C, Wang DW, Li J, Xiao X. Sustained whole-body functional rescue in congestive heart failure and muscular dystrophy hamsters by systemic gene transfer. Circulation. 112: 2650-9. PMID 16230483 DOI: 10.1161/Circulationaha.105.565598  0.408
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2005 Zhu T, Zhou L, Mori S, Wang Z, Mctiernan C, Qiao C, Chen C, Wang D, Li J, Xiao X. 916. Sustained Whole-Body Functional Rescue by Systemic Delivery of AAV8 Vectors in Heart Failure and Muscular Dystrophy Hamsters Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.459  0.436
2005 Wang B, Li J, Zhou L, Qiao C, Tian M, Zhu T, Bogan J, Kornegay J, Xiao X. 792. Canine Mini-Dystrophin Gene Transfer by AAV1 in mdx Mice Ameliorates Dystrophic Pathology and Protects Membrane Integrity Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.330  0.368
2005 Lai L, Li J, Huang SC, Lin K, Xiao X. 751. High Efficient Ex Vivo Gene Delivery into Human Corneal Endothelial Cells by Recombinant Adeno-Associated Virus Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.292  0.423
2005 Wang Z, Zhu T, Qiao C, Zhou L, Wang B, Zhang J, Chen C, Li J, Xiao X. 398. Adeno-Associated Virus Serotype 8 Efficiently Crosses Blood Vessel Barrier in Muscle and Heart for Whole-Body - Delivery Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.401  0.423
2005 Wang C, Master JH, Chen K, Cheng S, Xiao X, Ma H. 304. Gene Therapy of Malignant Brain Tumor by a Novel Double-Stranded Adeno-Associated Viral (AAV) Vector Carrying the Decorin Gene Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.307  0.406
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2004 Agha-Mohammadi S, O'Malley M, Etemad A, Wang Z, Xiao X, Lotze MT. Second-generation tetracycline-regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness. The Journal of Gene Medicine. 6: 817-28. PMID 15241789 DOI: 10.1002/Jgm.566  0.379
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2004 Ikezawa M, Cao B, Qu Z, Peng H, Xiao X, Pruchnic R, Kimura S, Miike T, Huard J. Dystrophin delivery in dystrophin-deficient DMDmdx skeletal muscle by isogenic muscle-derived stem cell transplantation. Human Gene Therapy. 14: 1535-46. PMID 14577915 DOI: 10.1089/104303403322495043  0.376
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2004 Lai L, Li J, Lin K, Wang Z, Zhu T, Xiao X. 655. Gene Therapy for Inhibition of Corneal Neovascularization in a Mice Model with Endostatin Delivered by Adeno-Associated Viral (AAV) Vector Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.601  0.334
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2000 Pan RY, Chen SL, Xiao X, Liu DW, Peng HJ, Tsao YP. Therapy and prevention of arthritis by recombinant adeno-associated virus vector with delivery of interleukin-1 receptor antagonist. Arthritis and Rheumatism. 43: 289-97. PMID 10693868 DOI: 10.1002/1529-0131(200002)43:2<289::Aid-Anr8>3.0.Co;2-H  0.323
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