Paul J. Muchowski - Publications

Affiliations: 
Neuroscience University of California, San Francisco, San Francisco, CA 
Area:
Neuroscience Biology, Immunology

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Aron R, Pellegrini P, Green EW, Maddison DC, Opoku-Nsiah K, Osorio Oliviera A, Wong JS, Daub AC, Giorgini F, Muchowski P, Finkbeiner S. Author Correction: Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington's disease. Nature Communications. 11: 1065. PMID 32081961 DOI: 10.1038/S41467-020-14582-9  0.328
2017 Chen MZ, Mok SA, Ormsby AR, Muchowski PJ, Hatters DM. N-Terminal Fragments of Huntingtin Longer than Residue 170 form Visible Aggregates Independently to Polyglutamine Expansion. Journal of Huntington's Disease. PMID 28339398 DOI: 10.3233/Jhd-160207  0.397
2016 Larkin PB, Sathyasaikumar KV, Notarangelo FM, Funakoshi H, Nakamura T, Schwarcz R, Muchowski PJ. Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice. Biochimica Et Biophysica Acta. PMID 27392942 DOI: 10.1016/J.Bbagen.2016.07.002  0.385
2016 Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S. αB-Crystallin over-expression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease. Human Molecular Genetics. PMID 26920069 DOI: 10.1093/Hmg/Ddw028  0.499
2013 Giorgini F, Huang SY, Sathyasaikumar KV, Notarangelo FM, Thomas MA, Tararina M, Wu HQ, Schwarcz R, Muchowski PJ. Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain. The Journal of Biological Chemistry. 288: 36554-66. PMID 24189070 DOI: 10.1074/Jbc.M113.503813  0.358
2013 Horne EA, Coy J, Swinney K, Fung S, Cherry AE, Marrs WR, Naydenov AV, Lin YH, Sun X, Keene CD, Grouzmann E, Muchowski P, Bates GP, Mackie K, Stella N. Downregulation of cannabinoid receptor 1 from neuropeptide Y interneurons in the basal ganglia of patients with Huntington's disease and mouse models. The European Journal of Neuroscience. 37: 429-40. PMID 23167744 DOI: 10.1111/Ejn.12045  0.365
2012 Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings BJ, Glabe CG, Muchowski PJ, Thompson LM. Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules. Journal of Huntington's Disease. 1: 127-40. PMID 24086178 DOI: 10.3233/Jhd-2012-129004  0.495
2012 Bouchard J, Truong J, Bouchard K, Dunkelberger D, Desrayaud S, Moussaoui S, Tabrizi SJ, Stella N, Muchowski PJ. Cannabinoid receptor 2 signaling in peripheral immune cells modulates disease onset and severity in mouse models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 18259-68. PMID 23238740 DOI: 10.1523/Jneurosci.4008-12.2012  0.352
2012 Kwan W, Träger U, Davalos D, Chou A, Bouchard J, Andre R, Miller A, Weiss A, Giorgini F, Cheah C, Möller T, Stella N, Akassoglou K, Tabrizi SJ, Muchowski PJ. Mutant huntingtin impairs immune cell migration in Huntington disease. The Journal of Clinical Investigation. 122: 4737-47. PMID 23160193 DOI: 10.1172/Jci64484  0.653
2012 Larkin PB, Muchowski PJ. Genetic Deficiency of Complement Component 3 Does Not Alter Disease Progression in a Mouse Model of Huntington's Disease. Journal of Huntington's Disease. 1: 107-18. PMID 23097680 DOI: 10.3233/Jhd-2012-120021  0.385
2012 Sontag EM, Lotz GP, Agrawal N, Tran A, Aron R, Yang G, Necula M, Lau A, Finkbeiner S, Glabe C, Marsh JL, Muchowski PJ, Thompson LM. Methylene blue modulates huntingtin aggregation intermediates and is protective in Huntington's disease models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11109-19. PMID 22875942 DOI: 10.1523/JNEUROSCI.0895-12.2012  0.437
2012 Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nature Reviews. Neuroscience. 13: 465-77. PMID 22678511 DOI: 10.1038/Nrn3257  0.347
2012 Green EW, Campesan S, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. Drosophila eye color mutants as therapeutic tools for Huntington disease. Fly. 6: 117-20. PMID 22634544 DOI: 10.4161/Fly.19999  0.472
2012 Nucifora LG, Burke KA, Feng X, Arbez N, Zhu S, Miller J, Yang G, Ratovitski T, Delannoy M, Muchowski PJ, Finkbeiner S, Legleiter J, Ross CA, Poirier MA. Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein. The Journal of Biological Chemistry. 287: 16017-28. PMID 22433867 DOI: 10.1074/Jbc.M111.252577  0.757
2012 Sancenon V, Lee SA, Patrick C, Griffith J, Paulino A, Outeiro TF, Reggiori F, Masliah E, Muchowski PJ. Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context. Human Molecular Genetics. 21: 2432-49. PMID 22357655 DOI: 10.1093/Hmg/Dds058  0.403
2012 Kwan W, Magnusson A, Chou A, Adame A, Carson MJ, Kohsaka S, Masliah E, Möller T, Ransohoff R, Tabrizi SJ, Björkqvist M, Muchowski PJ. Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 133-42. PMID 22219276 DOI: 10.1523/Jneurosci.4846-11.2012  0.619
2012 Träger U, André R, Lahiri N, Magnusson A, Pfister E, Weiss A, Grüninger S, Antoniou M, Bates G, Muchowski P, Björkqvist M, Ostroff G, Aronin N, Tabrizi S. B23 Immune dysfunction in HD human myeloid cells is caused by NFκB pathway dysregulation and is reversed by lowering HTT levels Journal of Neurology, Neurosurgery & Psychiatry. 83: A12.3-A13. DOI: 10.1136/Jnnp-2012-303524.39  0.369
2012 Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, ... ... Muchowski PJ, et al. Erratum: Corrigendum: Identifying polyglutamine protein species in situ that best predict neurodegeneration Nature Chemical Biology. 8: 318-318. DOI: 10.1038/Nchembio0312-318A  0.594
2011 Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, ... ... Muchowski PJ, et al. Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nature Chemical Biology. 7: 925-34. PMID 22037470 DOI: 10.1038/Nchembio.694  0.656
2011 Chen X, Wu J, Luo Y, Liang X, Supnet C, Kim MW, Lotz GP, Yang G, Muchowski PJ, Kodadek T, Bezprozvanny I. Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease. Chemistry & Biology. 18: 1113-25. PMID 21944750 DOI: 10.1016/J.Chembiol.2011.06.010  0.447
2011 Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, ... ... Muchowski PJ, et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 145: 863-74. PMID 21640374 DOI: 10.1016/J.Cell.2011.05.020  0.397
2011 Campesan S, Green EW, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Current Biology : Cb. 21: 961-6. PMID 21636279 DOI: 10.1016/J.Cub.2011.04.028  0.478
2011 Tauber E, Miller-Fleming L, Mason RP, Kwan W, Clapp J, Butler NJ, Outeiro TF, Muchowski PJ, Giorgini F. Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. The Journal of Biological Chemistry. 286: 410-9. PMID 21044956 DOI: 10.1074/Jbc.M110.101527  0.668
2010 Thevandavakkam MA, Schwarcz R, Muchowski PJ, Giorgini F. Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease. Cns & Neurological Disorders Drug Targets. 9: 791-800. PMID 20942784 DOI: 10.2174/187152710793237430  0.469
2010 Lotz GP, Legleiter J, Aron R, Mitchell EJ, Huang SY, Ng C, Glabe C, Thompson LM, Muchowski PJ. Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle. The Journal of Biological Chemistry. 285: 38183-93. PMID 20864533 DOI: 10.1074/Jbc.M110.160218  0.657
2010 Sathyasaikumar KV, Stachowski EK, Amori L, Guidetti P, Muchowski PJ, Schwarcz R. Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease. Journal of Neurochemistry. 113: 1416-25. PMID 20236387 DOI: 10.1111/J.1471-4159.2010.06675.X  0.405
2010 Legleiter J, Mitchell E, Lotz GP, Sapp E, Ng C, DiFiglia M, Thompson LM, Muchowski PJ. Mutant huntingtin fragments form oligomers in a polyglutamine length-dependent manner in vitro and in vivo. The Journal of Biological Chemistry. 285: 14777-90. PMID 20220138 DOI: 10.1074/Jbc.M109.093708  0.674
2010 Sathasivam K, Lane A, Legleiter J, Warley A, Woodman B, Finkbeiner S, Paganetti P, Muchowski PJ, Wilson S, Bates GP. Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease. Human Molecular Genetics. 19: 65-78. PMID 19825844 DOI: 10.1093/Hmg/Ddp467  0.663
2010 Schwarcz R, Guidetti P, Sathyasaikumar KV, Muchowski PJ. Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease. Progress in Neurobiology. 90: 230-45. PMID 19394403 DOI: 10.1016/J.Pneurobio.2009.04.005  0.472
2010 Campesan S, Green EW, Sathyasaikumar KV, Breda C, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. B06 Validation of KMO as a candidate therapeutic target for Huntington's disease in Drosophila melanogaster Journal of Neurology, Neurosurgery & Psychiatry. 81: A12.3-A13. DOI: 10.1136/Jnnp.2010.222596.6  0.458
2010 Zwilling D, Truong J, Andrews-Zwilling Y, Hsieh E, Louie J, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. An inhibitor of kynurenine 3-monooxygenase is neuroprotective in a mouse model of Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1975  0.354
2010 Legleiter J, Muchowski PJ. Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-Dependent Manner Biophysical Journal. 98: 457a. DOI: 10.1016/J.Bpj.2009.12.2483  0.691
2010 Muchowski PJ. Protein Folding and the Role of Chaperone Proteins in Neurodegenerative Disease Encyclopedia of Neuroscience. 1163-1166. DOI: 10.1016/B978-008045046-9.00524-6  0.36
2009 Wacker JL, Huang SY, Steele AD, Aron R, Lotz GP, Nguyen Q, Giorgini F, Roberson ED, Lindquist S, Masliah E, Muchowski PJ. Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9104-14. PMID 19605647 DOI: 10.1523/Jneurosci.2250-09.2009  0.492
2009 Muccioli GG, Sia A, Muchowski PJ, Stella N. Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae. Plos One. 4: e5942. PMID 19529773 DOI: 10.1371/Journal.Pone.0005942  0.648
2009 Giorgini F, Muchowski PJ. Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease. Methods in Molecular Biology (Clifton, N.J.). 548: 161-74. PMID 19521824 DOI: 10.1007/978-1-59745-540-4_9  0.459
2009 Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ. Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment. The Journal of Biological Chemistry. 284: 21647-58. PMID 19491400 DOI: 10.1074/Jbc.M109.016923  0.648
2009 Sia AM, Muchowski PJ. Genetic screens in yeast to identify modifiers of beta-amyloid-induced toxicity Alzheimers & Dementia. 5: 177. DOI: 10.1016/J.Jalz.2009.04.023  0.304
2008 Trinh K, Moore K, Wes PD, Muchowski PJ, Dey J, Andrews L, Pallanck LJ. Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 465-72. PMID 18184789 DOI: 10.1523/Jneurosci.4778-07.2008  0.341
2008 Muchowski PJ, Ramsden R, Nguyen Q, Arnett EE, Greiling TM, Anderson SK, Clark JI. Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens. The Journal of Biological Chemistry. 283: 6330-6. PMID 18167346 DOI: 10.1074/Jbc.M709678200  0.506
2008 Giorgini F, Möller T, Kwan W, Zwilling D, Wacker JL, Hong S, Tsai LC, Cheah CS, Schwarcz R, Guidetti P, Muchowski PJ. Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. The Journal of Biological Chemistry. 283: 7390-400. PMID 18079112 DOI: 10.1074/Jbc.M708192200  0.698
2007 Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L. Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. The Journal of Biological Chemistry. 282: 23818-28. PMID 17548355 DOI: 10.1074/Jbc.M701078200  0.622
2007 Rosser MF, Washburn E, Muchowski PJ, Patterson C, Cyr DM. Chaperone functions of the E3 ubiquitin ligase CHIP. The Journal of Biological Chemistry. 282: 22267-77. PMID 17545168 DOI: 10.1074/Jbc.M700513200  0.344
2006 Giorgini F, Muchowski PJ. Screening for genetic modifiers of amyloid toxicity in yeast. Methods in Enzymology. 412: 201-22. PMID 17046660 DOI: 10.1016/S0076-6879(06)12013-3  0.409
2006 Finkbeiner S, Cuervo AM, Morimoto RI, Muchowski PJ. Disease-modifying pathways in neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10349-57. PMID 17035516 DOI: 10.1523/Jneurosci.3829-06.2006  0.456
2006 Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter J, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE. Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Human Molecular Genetics. 15: 2743-51. PMID 16893904 DOI: 10.1093/Hmg/Ddl210  0.705
2006 Duennwald ML, Jagadish S, Muchowski PJ, Lindquist S. Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proceedings of the National Academy of Sciences of the United States of America. 103: 11045-50. PMID 16832050 DOI: 10.1073/Pnas.0604547103  0.437
2006 Duennwald ML, Jagadish S, Giorgini F, Muchowski PJ, Lindquist S. A network of protein interactions determines polyglutamine toxicity. Proceedings of the National Academy of Sciences of the United States of America. 103: 11051-6. PMID 16832049 DOI: 10.1073/Pnas.0604548103  0.422
2005 Giorgini F, Guidetti P, Nguyen Q, Bennett SC, Muchowski PJ. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nature Genetics. 37: 526-31. PMID 15806102 DOI: 10.1038/Ng1542  0.497
2005 Giorgini F, Muchowski PJ. Connecting the dots in Huntington's disease with protein interaction networks. Genome Biology. 6: 210. PMID 15774033 DOI: 10.1186/Gb-2005-6-3-210  0.414
2005 Muchowski PJ, Wacker JL. Modulation of neurodegeneration by molecular chaperones. Nature Reviews. Neuroscience. 6: 11-22. PMID 15611723 DOI: 10.1038/Nrn1587  0.486
2004 Wacker JL, Zareie MH, Fong H, Sarikaya M, Muchowski PJ. Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer. Nature Structural & Molecular Biology. 11: 1215-22. PMID 15543156 DOI: 10.1038/Nsmb860  0.422
2004 Outeiro TF, Muchowski PJ. Molecular genetics approaches in yeast to study amyloid diseases. Journal of Molecular Neuroscience : Mn. 23: 49-60. PMID 15126692 DOI: 10.1385/Jmn:23:1-2:049  0.5
2003 Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science (New York, N.Y.). 302: 1769-72. PMID 14657499 DOI: 10.1126/Science.1090389  0.414
2003 Miller LC, Swayne LA, Chen L, Feng ZP, Wacker JL, Muchowski PJ, Zamponi GW, Braun JE. Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin. The Journal of Biological Chemistry. 278: 53072-81. PMID 14570907 DOI: 10.1074/Jbc.M306230200  0.36
2003 Sherman MY, Muchowski PJ. Making yeast tremble: yeast models as tools to study neurodegenerative disorders. Neuromolecular Medicine. 4: 133-46. PMID 14528057 DOI: 10.1385/Nmm:4:1-2:133  0.409
2002 Muchowski PJ. Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones? Neuron. 35: 9-12. PMID 12123602 DOI: 10.1016/S0896-6273(02)00761-4  0.473
2002 Valdez MM, Clark JI, Wu GJ, Muchowski PJ. Functional similarities between the small heat shock proteins Mycobacterium tuberculosis HSP 16.3 and human alphaB-crystallin. European Journal of Biochemistry / Febs. 269: 1806-13. PMID 11952782 DOI: 10.1046/J.1432-1033.2002.02812.X  0.352
2002 Muchowski PJ, Ning K, D'Souza-Schorey C, Fields S. Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment. Proceedings of the National Academy of Sciences of the United States of America. 99: 727-32. PMID 11792857 DOI: 10.1073/Pnas.022628699  0.431
2001 Derham BK, van Boekel MA, Muchowski PJ, Clark JI, Horwitz J, Hepburne-Scott HW, de Jong WW, Crabbe MJ, Harding JJ. Chaperone function of mutant versions of alpha A- and alpha B-crystallin prepared to pinpoint chaperone binding sites. European Journal of Biochemistry / Febs. 268: 713-21. PMID 11168410 DOI: 10.1046/J.1432-1327.2001.01929.X  0.347
2000 Muchowski PJ, Schaffar G, Sittler A, Wanker EE, Hayer-Hartl MK, Hartl FU. Hsp70 and hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils. Proceedings of the National Academy of Sciences of the United States of America. 97: 7841-6. PMID 10859365 DOI: 10.1073/Pnas.140202897  0.424
2000 Clark JI, Muchowski PJ. Small heat-shock proteins and their potential role in human disease Current Opinion in Structural Biology. 10: 52-59. PMID 10679464 DOI: 10.1016/S0959-440X(99)00048-2  0.425
1999 Perng MD, Muchowski PJ, van Den IJssel P, Wu GJ, Hutcheson AM, Clark JI, Quinlan RA. The cardiomyopathy and lens cataract mutation in alphaB-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro. The Journal of Biological Chemistry. 274: 33235-43. PMID 10559197 DOI: 10.1074/Jbc.274.47.33235  0.43
1999 Muchowski PJ, Wu GJS, Liang JJN, Adman ET, Clark JI. Site-directed mutations within the core 'α-crystallin' domain of the small heat-shock protein, human αB-crystallin, decrease molecular chaperone functions Journal of Molecular Biology. 289: 397-411. PMID 10366513 DOI: 10.1006/Jmbi.1999.2759  0.372
1999 Bassuk JA, Birkebak T, Rothmier JD, Clark JM, Bradshaw A, Muchowski PJ, Howe CC, Clark JI, Sage EH. Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation Experimental Eye Research. 68: 321-331. PMID 10079140 DOI: 10.1006/Exer.1998.0608  0.306
1998 Muchowski PJ, Clark JI. ATP-enhanced molecular chaperone functions of the small heat shock protein human αB crystallin Proceedings of the National Academy of Sciences of the United States of America. 95: 1004-1009. PMID 9448275 DOI: 10.1073/Pnas.95.3.1004  0.365
1997 Muchowski PJ, Bassuk JA, Lubsen NH, Clark JI. Human αB-crystallin. Small heat shock protein and molecular chaperone Journal of Biological Chemistry. 272: 2578-2582. PMID 8999975 DOI: 10.1074/Jbc.272.4.2578  0.366
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