Ming-Wei Wang - Publications

Affiliations: 
The National Drug Screening Center 

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW. Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G proteins. Cell Discovery. 10: 18. PMID 38346960 DOI: 10.1038/s41421-024-00649-0  0.371
2023 Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW. Molecular basis of signal transduction mediated by the human GIPR splice variants. Proceedings of the National Academy of Sciences of the United States of America. 120: e2306145120. PMID 37792509 DOI: 10.1073/pnas.2306145120  0.336
2023 Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z. Structural analysis of the dual agonism at GLP-1R and GCGR. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303696120. PMID 37549266 DOI: 10.1073/pnas.2303696120  0.398
2023 Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, ... ... Wang MW, et al. Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4). Nature Communications. 14: 492. PMID 36717591 DOI: 10.1038/s41467-023-36182-z  0.363
2022 Darbalaei S, Chang RL, Zhou QT, Chen Y, Dai AT, Wang MW, Yang DH. Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists. Acta Pharmacologica Sinica. PMID 35953646 DOI: 10.1038/s41401-022-00962-y  0.435
2022 Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, ... ... Wang MW, et al. Structural insights into ligand recognition and selectivity of somatostatin receptors. Cell Research. PMID 35739238 DOI: 10.1038/s41422-022-00679-x  0.346
2022 Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW. Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200155119. PMID 35561211 DOI: 10.1073/pnas.2200155119  0.346
2022 Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, ... Wang MW, et al. A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nature Communications. 13: 2272. PMID 35477937 DOI: 10.1038/s41467-022-30041-z  0.371
2022 Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, ... Wang MW, et al. Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors. Nature Communications. 13: 1057. PMID 35217653 DOI: 10.1038/s41467-022-28683-0  0.393
2022 Cong Z, Liang YL, Zhou Q, Darbalaei S, Zhao F, Feng W, Zhao L, Xu HE, Yang D, Wang MW. Structural perspective of class B1 GPCR signaling. Trends in Pharmacological Sciences. PMID 35078643 DOI: 10.1016/j.tips.2022.01.002  0.307
2021 Shao L, Chen Y, Zhang S, Zhang Z, Cao Y, Yang D, Wang MW. Modulating effects of RAMPs on signaling profiles of the glucagon receptor family. Acta Pharmaceutica Sinica. B. 12: 637-650. PMID 35256936 DOI: 10.1016/j.apsb.2021.07.028  0.343
2021 Lin G, Feng Y, Cai X, Zhou C, Shao L, Chen Y, Chen L, Liu Q, Zhou Q, Bathgate RAD, Yang D, Wang MW. High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist. Molecules (Basel, Switzerland). 26. PMID 34946593 DOI: 10.3390/molecules26247511  0.349
2021 Chen Y, Xu YN, Ye CY, Feng WB, Zhou QT, Yang DH, Wang MW. GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis. Acta Pharmacologica Sinica. PMID 34934197 DOI: 10.1038/s41401-021-00836-9  0.352
2021 Wang J, Yang D, Cheng X, Yang L, Wang Z, Dai A, Cai X, Zhang C, Yuliantie E, Liu Q, Jiang H, Liu H, Wang MW, Yang H. Allosteric Modulators Enhancing GLP-1 Binding to GLP-1R via a Transmembrane Site. Acs Chemical Biology. PMID 34570476 DOI: 10.1021/acschembio.1c00552  0.334
2021 Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, ... Wang MW, et al. Structures of the human cholecystokinin receptors bound to agonists and antagonists. Nature Chemical Biology. PMID 34556863 DOI: 10.1038/s41589-021-00866-8  0.367
2021 Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y. Molecular basis for kinin selectivity and activation of the human bradykinin receptors. Nature Structural & Molecular Biology. 28: 755-761. PMID 34518695 DOI: 10.1038/s41594-021-00645-y  0.318
2021 Wang YZ, Yang DH, Wang MW. Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors. Acta Pharmacologica Sinica. PMID 34446852 DOI: 10.1038/s41401-021-00758-6  0.369
2021 Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, et al. Structural insights into ligand recognition and activation of the melanocortin-4 receptor. Cell Research. PMID 34433901 DOI: 10.1038/s41422-021-00552-3  0.359
2021 Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW. Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34353904 DOI: 10.1073/pnas.2101279118  0.342
2021 Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu E, ... Wang MW, et al. Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor. Elife. 10. PMID 34254582 DOI: 10.7554/eLife.68719  0.323
2021 Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, ... Wang MW, et al. Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor. Nature Communications. 12: 3763. PMID 34145245 DOI: 10.1038/s41467-021-24058-z  0.368
2020 Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, ... Wang MW, et al. A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor. Cell Research. PMID 33239759 DOI: 10.1038/s41422-020-00442-0  0.41
2020 Darbalaei S, Yuliantie E, Dai A, Chang R, Zhao P, Yang D, Wang MW, Sexton PM, Wootten D. Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors. Biochemical Pharmacology. 114150. PMID 32682761 DOI: 10.1016/j.bcp.2020.114150  0.448
2020 Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang YL, Ma L, Han S, Yang D, Danev R, Wang MW, et al. Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide. The Journal of Biological Chemistry. PMID 32371397 DOI: 10.1074/Jbc.Ra120.013793  0.391
2020 Yuliantie E, Darbalaei S, Dai A, Zhao P, Yang D, Sexton PM, Wang MW, Wootten D. Pharmacological characterization of mono-, dual- and tri- peptidic agonists at GIP and GLP-1 receptors. Biochemical Pharmacology. 114001. PMID 32360365 DOI: 10.1016/j.bcp.2020.114001  0.412
2020 Wang YZ, Liu X, Way G, Madarha V, Zhou QT, Yang DH, Liao JY, Wang MW. An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9. Acta Pharmacologica Sinica. PMID 32341466 DOI: 10.1038/S41401-020-0405-7  0.46
2020 Lin GY, Lin L, Cai XQ, Dai AT, Zhu Y, Li J, Liu Q, Yang DH, Bathgate RAD, Wang MW. High-throughput screening campaign identifies a small molecule agonist of the relaxin family peptide receptor 4. Acta Pharmacologica Sinica. PMID 32235863 DOI: 10.1038/s41401-020-0390-x  0.432
2020 Wu F, Yang L, Hang K, Laursen M, Wu L, Han GW, Ren Q, Roed NK, Lin G, Hanson MA, Jiang H, Wang MW, Reedtz-Runge S, Song G, Stevens RC. Full-length human GLP-1 receptor structure without orthosteric ligands. Nature Communications. 11: 1272. PMID 32152292 DOI: 10.1038/S41467-020-14934-5  0.408
2020 Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, et al. Molecular Basis for Hormone Recognition and Activation of Corticotropin-Releasing Factor Receptors. Molecular Cell. PMID 32004470 DOI: 10.1016/J.Molcel.2020.01.013  0.309
2020 Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, et al. Activation of the GLP-1 receptor by a non-peptidic agonist. Nature. PMID 31915381 DOI: 10.1038/S41586-019-1902-Z  0.414
2019 Pham V, Zhu Y, Dal Maso E, Reynolds CA, Deganutti G, Atanasio S, Hick CA, Yang D, Christopoulos A, Hay DL, Furness SGB, Wang MW, Wootten D, Sexton PM. Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor. Acs Pharmacology & Translational Science. 2: 183-197. PMID 32219220 DOI: 10.1021/acsptsci.9b00010  0.356
2019 Dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S, Reynolds CA, Ramírez-Aportela E, Carazo JM, Hick CA, Furness SGB, Hay DL, Liang YL, Miller LJ, Christopoulos A, Wang MW, et al. The Molecular Control of Calcitonin Receptor Signaling. Acs Pharmacology & Translational Science. 2: 31-51. PMID 32219215 DOI: 10.1021/acsptsci.8b00056  0.316
2019 Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, ... Wang MW, et al. Structure and dynamics of the active human parathyroid hormone receptor-1. Science (New York, N.Y.). 364: 148-153. PMID 30975883 DOI: 10.1126/science.aav7942  0.311
2018 Lei S, Clydesdale L, Dai A, Cai X, Feng Y, Yang D, Liang YL, Koole C, Zhao P, Coudrat T, Christopoulos A, Wang MW, Wootten D, Sexton PM. Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism. The Journal of Biological Chemistry. PMID 29717000 DOI: 10.1074/jbc.RA118.003278  0.395
2018 Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, et al. Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. Nature. PMID 29466332 DOI: 10.1038/Nature25773  0.358
2018 Dal Maso E, Zhu Y, Pham V, Reynolds CA, Deganutti G, Hick CA, Yang D, Christopoulos A, Hay DL, Wang MW, Sexton PM, Furness SGB, Wootten D. Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochemical Pharmacology. PMID 29454620 DOI: 10.1016/J.Bcp.2018.02.005  0.428
2018 Zhang H, Qiao A, Yang L, Van Eps N, Frederiksen KS, Yang D, Dai A, Cai X, Zhang H, Yi C, Cao C, He L, Yang H, Lau J, Ernst OP, ... Wang MW, et al. Structure of the glucagon receptor in complex with a glucagon analogue. Nature. 553: 106-110. PMID 29300013 DOI: 10.1038/Nature25153  0.343
2017 Song G, Yang D, Wang Y, de Graaf C, Zhou Q, Jiang S, Liu K, Cai X, Dai A, Lin G, Liu D, Wu F, Wu Y, Zhao S, Ye L, ... Wang MW, et al. Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. PMID 28514449 DOI: 10.1038/Nature22378  0.371
2016 Graaf C, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, Ahn JM, Liao J, Fletcher MM, Yang D, Brown AJ, Zhou C, Deng J, Wang MW. Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes. Pharmacological Reviews. 68: 954-1013. PMID 27630114 DOI: 10.1124/pr.115.011395  0.602
2016 Zhao LH, Yin Y, Yang D, Liu B, Hou L, Wang X, Pal K, Jiang Y, Feng Y, Cai X, Dai A, Liu M, Wang MW, Melcher K, Xu HE. Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-Coupled Receptors. The Journal of Biological Chemistry. PMID 27226600 DOI: 10.1074/Jbc.M116.726620  0.353
2016 Shu S, Cai X, Li J, Feng Y, Dai A, Wang J, Yang D, Wang MW, Liu H. Design, synthesis, structure-activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists. Bioorganic & Medicinal Chemistry. PMID 27161876 DOI: 10.1016/j.bmc.2016.04.053  0.32
2016 Yang D, de Graaf C, Yang L, Song G, Dai A, Cai X, Feng Y, Reedtz-Runge S, Hanson MA, Yang H, Jiang H, Stevens RC, Wang MW. Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor. The Journal of Biological Chemistry. PMID 27059958 DOI: 10.1074/Jbc.M116.721977  0.357
2015 Yang DH, Zhou CH, Liu Q, Wang MW. Landmark studies on the glucagon subfamily of GPCRs: from small molecule modulators to a crystal structure. Acta Pharmacologica Sinica. PMID 26279155 DOI: 10.1038/aps.2015.78  0.367
2015 Luo X, Li T, Zhu Y, Dai Y, Zhao J, Guo ZY, Wang MW. The insulinotrophic effect of insulin-like peptide 5 in vitro and in vivo. The Biochemical Journal. 466: 467-73. PMID 25514935 DOI: 10.1042/BJ20141113  0.306
2015 Fan H, Gong N, Li TF, Ma AN, Wu XY, Wang MW, Wang YX. The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia. British Journal of Pharmacology. 172: 64-79. PMID 25176008 DOI: 10.1111/bph.12895  0.329
2014 Ge Y, Yang D, Dai A, Zhou C, Zhu Y, Wang MW. The putative signal peptide of glucagon-like peptide-1 receptor is not required for receptor synthesis but promotes receptor expression. Bioscience Reports. 34: e00152. PMID 25330813 DOI: 10.1042/BSR20140120  0.38
2013 Siu FY, He M, de Graaf C, Han GW, Yang D, Zhang Z, Zhou C, Xu Q, Wacker D, Joseph JS, Liu W, Lau J, Cherezov V, Katritch V, Wang MW, et al. Structure of the human glucagon class B G-protein-coupled receptor. Nature. 499: 444-9. PMID 23863937 DOI: 10.1038/Nature12393  0.303
2013 Zhang M, Feng Y, Wang J, Zhao J, Li T, He M, Yang D, Nosjean O, Boutin J, Renard P, Wang MW. High-throughput screening for GPR119 modulators identifies a novel compound with anti-diabetic efficacy in db/db mice. Plos One. 8: e63861. PMID 23704946 DOI: 10.1371/journal.pone.0063861  0.33
2013 Bartfai T, Wang MW. Positive allosteric modulators to peptide GPCRs: a promising class of drugs. Acta Pharmacologica Sinica. 34: 880-5. PMID 23624758 DOI: 10.1038/aps.2013.20  0.373
2013 He HQ, Liao D, Wang ZG, Wang ZL, Zhou HC, Wang MW, Ye RD. Functional characterization of three mouse formyl peptide receptors. Molecular Pharmacology. 83: 389-98. PMID 23160941 DOI: 10.1124/Mol.112.081315  0.362
2012 He M, Guan N, Gao WW, Liu Q, Wu XY, Ma DW, Zhong DF, Ge GB, Li C, Chen XY, Yang L, Liao JY, Wang MW. A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities. Acta Pharmacologica Sinica. 33: 148-54. PMID 22301855 DOI: 10.1038/Aps.2011.169  0.597
2012 Liu Q, Li N, Yuan Y, Lu H, Wu X, Zhou C, He M, Su H, Zhang M, Wang J, Wang B, Wang Y, Ma D, Ye Y, Weiss HC, ... Wang MW, et al. Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor. Journal of Medicinal Chemistry. 55: 250-67. PMID 22103243 DOI: 10.1021/Jm201150J  0.577
2010 He M, Su H, Gao W, Johansson SM, Liu Q, Wu X, Liao J, Young AA, Bartfai T, Wang MW. Reversal of obesity and insulin resistance by a non-peptidic glucagon-like peptide-1 receptor agonist in diet-induced obese mice. Plos One. 5: e14205. PMID 21151924 DOI: 10.1371/journal.pone.0014205  0.565
2010 Wang MW, Liu Q, Zhou CH. Non-peptidic glucose-like peptide-1 receptor agonists: aftermath of a serendipitous discovery. Acta Pharmacologica Sinica. 31: 1026-30. PMID 20676118 DOI: 10.1038/aps.2010.107  0.447
2010 Ye N, Wang MW, Qin J, Lin B. Microfluidic devices for characterizing the agonist of formyl peptide receptor in RBL-FPR cells. Biomedical Microdevices. 12: 513-21. PMID 20195765 DOI: 10.1007/s10544-010-9408-3  0.335
2010 Li QY, Zhang M, Hallis TM, Derosier TA, Yue JM, Ye Y, Mais DE, Wang MW. Characterization of a novel non-steroidal glucocorticoid receptor antagonist. Biochemical and Biophysical Research Communications. 391: 1531-6. PMID 20035723 DOI: 10.1016/j.bbrc.2009.12.117  0.345
2009 Liu Q, Zhang YY, Lu HL, Li QY, Zhou CH, Wang MW. Rhodanine derivatives as novel peroxisome proliferator-activated receptor gamma agonists. Acta Pharmacologica Sinica. 28: 2033-9. PMID 18031620  0.313
2008 Su H, He M, Li H, Liu Q, Wang J, Wang Y, Gao W, Zhou L, Liao J, Young AA, Wang MW. Boc5, a non-peptidic glucagon-like Peptide-1 receptor agonist, invokes sustained glycemic control and weight loss in diabetic mice. Plos One. 3: e2892. PMID 18682834 DOI: 10.1371/journal.pone.0002892  0.58
2008 Meng T, Su HR, Binkert C, Fischli W, Zhou L, Shen JK, Wang MW. Identification of non-peptidic neuromedin U receptor modulators by a robust homogeneous screening assay. Acta Pharmacologica Sinica. 29: 517-27. PMID 18358099 DOI: 10.1111/j.1745-7254.2008.00769.x  0.403
2007 Zhou C, Zhang S, Nanamori M, Zhang Y, Liu Q, Li N, Sun M, Tian J, Ye PP, Cheng N, Ye RD, Wang MW. Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1. Molecular Pharmacology. 72: 976-83. PMID 17652444 DOI: 10.1124/Mol.107.037564  0.323
2007 Wan HX, Zhou C, Zhang Y, Sun M, Wang X, Yu H, Yang X, Ye RD, Shen JK, Wang MW. Discovery of Trp-Nle-Tyr-Met as a novel agonist for human formyl peptide receptor-like 1. Biochemical Pharmacology. 74: 317-26. PMID 17517377 DOI: 10.1016/J.Bcp.2007.04.016  0.368
2007 Chen D, Liao J, Li N, Zhou C, Liu Q, Wang G, Zhang R, Zhang S, Lin L, Chen K, Xie X, Nan F, Young AA, Wang MW. A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proceedings of the National Academy of Sciences of the United States of America. 104: 943-8. PMID 17213311 DOI: 10.1073/pnas.0610173104  0.582
2007 Zhang R, Yan PK, Zhou CH, Liao JY, Wang MW. Development of a homogeneous calcium mobilization assay for high throughput screening of mas-related gene receptor agonists. Acta Pharmacologica Sinica. 28: 125-31. PMID 17184592 DOI: 10.1111/j.1745-7254.2007.00451.x  0.488
2004 Nanamori M, Cheng X, Mei J, Sang H, Xuan Y, Zhou C, Wang MW, Ye RD. A novel nonpeptide ligand for formyl peptide receptor-like 1. Molecular Pharmacology. 66: 1213-1222. PMID 15308762 DOI: 10.1124/Mol.104.004309  0.354
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