Edward W. Tate, Ph.D. - Publications

Affiliations: 
Chemistry Imperial College, London, London, England, United Kingdom 
Area:
chemical Biology, organic chemistry, medicinal chemistry
Website:
http://www3.imperial.ac.uk/people/e.tate

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yahiya S, Saunders CN, Hassan S, Straschil U, Fischer OJ, Rueda-Zubiaurre A, Haase S, Vizcay-Barrena G, Famodimu MT, Jordan S, Delves MJ, Tate EW, Barnard A, Fuchter MJ, Baum J. A novel class of sulphonamides potently block malaria transmission by targeting a Plasmodium vacuole membrane protein. Disease Models & Mechanisms. 16. PMID 36715290 DOI: 10.1242/dmm.049950  0.725
2021 Jamshidiha M, Lanyon-Hogg T, Sutherell CL, Craven GB, Tersa M, De Vita E, Brustur D, Pérez-Dorado I, Hassan S, Petracca R, Morgan RM, Sanz-Hernández M, Norman JC, Armstrong A, Mann DJ, ... ... Tate EW, et al. Identification of the first structurally validated covalent ligands of the small GTPase RAB27A. Rsc Medicinal Chemistry. 13: 150-155. PMID 35308027 DOI: 10.1039/d1md00225b  0.785
2021 Panyain N, Godinat A, Thawani AR, Lachiondo-Ortega S, Mason K, Elkhalifa S, Smith LM, Harrigan JA, Tate EW. Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe. Rsc Medicinal Chemistry. 12: 1935-1943. PMID 34820624 DOI: 10.1039/d1md00218j  0.321
2020 Benns HJ, Wincott CJ, Tate EW, Child MA. Activity- and reactivity-based proteomics: Recent technological advances and applications in drug discovery. Current Opinion in Chemical Biology. 60: 20-29. PMID 32768892 DOI: 10.1016/J.Cbpa.2020.06.011  0.351
2020 Broncel M, Dominicus C, Vigetti L, Nofal SD, Bartlett EJ, Touquet B, Hunt A, Wallbank BA, Federico S, Matthews S, Young JC, Tate EW, Tardieux I, Treeck M. Profiling of myristoylation in reveals an -myristoylated protein important for host cell penetration. Elife. 9. PMID 32618271 DOI: 10.7554/Elife.57861  0.391
2020 Panyain N, Godinat A, Lanyon-Hogg T, Lachiondo-Ortega S, Will EJ, Soudy C, Mondal M, Mason K, Elkhalifa S, Smith L, Harrigan JA, Tate EW. Discovery of a potent and selective covalent inhibitor and activity-based probe for the deubiquitylating enzyme UCHL1, with anti-fibrotic activity. Journal of the American Chemical Society. PMID 32579346 DOI: 10.1021/Jacs.0C04527  0.392
2020 Bell AS, Yu Z, Hutton JA, Wright MH, Brannigan JA, Paape D, Roberts SM, Sutherell CL, Ritzefeld M, Wilkinson AJ, Smith DF, Leatherbarrow R, Tate EW. Novel thienopyrimidine inhibitors of -myristoyltransferase with on-target activity in intracellular amastigotes. Journal of Medicinal Chemistry. PMID 32575985 DOI: 10.1021/Acs.Jmedchem.0C00570  0.646
2020 Anderson DP, Benns HJ, Tate EW, Child MA. CRISPR-TAPE: protein-centric CRISPR guide design for targeted proteome engineering. Molecular Systems Biology. 16: e9475. PMID 32485092 DOI: 10.15252/Msb.20209475  0.316
2020 Shchepinova MM, Hanyaloglu AC, Frost GS, Tate EW. Chemical biology of noncanonical G protein-coupled receptor signaling: Toward advanced therapeutics. Current Opinion in Chemical Biology. 56: 98-110. PMID 32446179 DOI: 10.1016/J.Cbpa.2020.04.012  0.311
2020 Saunders CN, Cota E, Baum J, Tate EW. Peptide Probes for MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex. Acs Chemical Biology. PMID 32383851 DOI: 10.1021/Acschembio.0C00328  0.376
2020 Maneiro M, Forte N, Shchepinova MM, Kounde CS, Chudasama V, Baker JR, Tate EW. Antibody-PROTAC conjugates enable HER2-dependent targeted protein degradation of BRD4. Acs Chemical Biology. PMID 32338867 DOI: 10.1021/Acschembio.0C00285  0.373
2020 Kounde CS, Shchepinova MM, Saunders CN, Muelbaier M, Rackham MD, Harling JD, Tate EW. A caged E3 ligase ligand for PROTAC-mediated protein degradation with light. Chemical Communications (Cambridge, England). PMID 32297626 DOI: 10.1039/D0Cc00523A  0.301
2020 Dian C, Pérez-Dorado I, Rivière F, Asensio T, Legrand P, Ritzefeld M, Shen M, Cota E, Meinnel T, Tate EW, Giglione C. High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation. Nature Communications. 11: 1132. PMID 32111831 DOI: 10.1038/S41467-020-14847-3  0.371
2020 Ward JA, Pinto-Fernandez A, Cornelissen L, Bonham S, Díaz-Sáez L, Riant O, Huber KVM, Kessler BM, Feron O, Tate EW. Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs. Journal of Medicinal Chemistry. PMID 32109059 DOI: 10.1021/Acs.Jmedchem.0C00144  0.392
2020 Lucy D, Zhang L, Tate EW. A Natural Product Puts Malaria on a Low-Fat Diet. Cell Chemical Biology. 27: 137-139. PMID 32084335 DOI: 10.1016/J.Chembiol.2020.02.001  0.342
2020 Howard RT, Hemsley P, Petteruti P, Saunders CN, Molina Bermejo JA, Scott JS, Johannes JW, Tate EW. Structure-guided design and in-cell target profiling of a cell-active target engagement probe for PARP inhibitors. Acs Chemical Biology. PMID 32017532 DOI: 10.1021/Acschembio.9B00963  0.385
2020 Broncel M, Dominicus C, Vigetti L, Nofal SD, Bartlett EJ, Touquet B, Hunt A, Wallbank BA, Federico S, Matthews S, Young JC, Tate EW, Tardieux I, Treeck M. Author response: Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration Elife. DOI: 10.7554/Elife.57861.Sa2  0.33
2019 Goya Grocin A, Serwa RA, Morales Sanfrutos J, Ritzefeld M, Tate EW. Whole Proteome Profiling of N-Myristoyltransferase Activity and Inhibition Using Sortase A. Molecular & Cellular Proteomics : McP. 18: 115-126. PMID 33451663 DOI: 10.1074/mcp.RA118.001043  0.305
2019 Conole D, Mondal M, Majmudar JD, Tate EW. Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes. Frontiers in Chemistry. 7: 876. PMID 31921788 DOI: 10.3389/Fchem.2019.00876  0.345
2019 Lanyon-Hogg T, Ritzefeld M, Sefer L, Bickel JK, Rudolf AF, Panyain N, Bineva-Todd G, Ocasio CA, O'Reilly N, Siebold C, Magee AI, Tate EW. Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes. Chemical Science. 10: 8995-9000. PMID 31762980 DOI: 10.1039/C9Sc01785B  0.362
2019 Serwa RA, Sekine E, Brown J, Teo SHC, Tate EW, O'Hare P. Analysis of a fully infectious bio-orthogonally modified human virus reveals novel features of virus cell entry. Plos Pathogens. 15: e1007956. PMID 31589653 DOI: 10.1371/Journal.Ppat.1007956  0.313
2019 Rueda-Zubiaurre A, Yahiya S, Fischer O, Hu X, Saunders C, Sharma S, Straschil U, Shen J, Tate EW, Delves M, Baum J, Barnard A, Fuchter MJ. Structure-activity relationship studies of a novel class of transmission blocking antimalarials targeting male gametes. Journal of Medicinal Chemistry. PMID 31490680 DOI: 10.1021/Acs.Jmedchem.9B00898  0.707
2019 Schlott AC, Mayclin S, Reers AR, Coburn-Flynn O, Bell AS, Green J, Knuepfer E, Charter D, Bonnert R, Campo B, Burrows J, Lyons-Abbott S, Staker BL, Chung CW, Myler PJ, ... ... Tate EW, et al. Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors. Cell Chemical Biology. PMID 31080074 DOI: 10.1016/J.Chembiol.2019.03.015  0.4
2019 Kallemeijn WW, Lueg GA, Faronato M, Hadavizadeh K, Goya Grocin A, Song OR, Howell M, Calado DP, Tate EW. Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases. Cell Chemical Biology. PMID 31006618 DOI: 10.1016/J.Chembiol.2019.03.006  0.419
2019 Storck EM, Morales-Sanfrutos J, Serwa RA, Panyain N, Lanyon-Hogg T, Tolmachova T, Ventimiglia LN, Martin-Serrano J, Seabra MC, Wojciak-Stothard B, Tate EW. Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics. Nature Chemistry. PMID 30936521 DOI: 10.1038/S41557-019-0237-6  0.371
2019 Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven A, ... ... Tate EW, et al. AWZ1066S, a highly specific anti- drug candidate for a short-course treatment of filariasis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30617067 DOI: 10.1073/Pnas.1816585116  0.306
2018 Goya Grocin A, Serwa RA, Morales Sanfrutos J, Ritzefeld M, Tate EW. Whole proteome profiling of -myristoyltransferase activity and inhibition using Sortase-A. Molecular & Cellular Proteomics : McP. PMID 30341083 DOI: 10.1074/Mcp.Ra118.001043  0.421
2018 Wang Z, Grosskurth SE, Cheung T, Petteruti P, Zhang J, Wang X, Wang W, Gharahdaghi F, Wu J, Su N, Howard RT, Mayo M, Widzowski D, Scott DA, Johannes JW, ... ... Tate EW, et al. Pharmacological inhibition of PARP6 triggers multipolar spindle formation and elicits therapeutic effects in breast cancer. Cancer Research. PMID 30297535 DOI: 10.1158/0008-5472.Can-18-1362  0.356
2018 De Vita E, Schüler P, Lovell S, Lohbeck J, Kullmann S, Rabinovich E, Sananes A, Heßling B, Hamon V, Papo N, Heß J, Tate EW, Gunkel N, Miller AK. Depsipeptides featuring a neutral P1 are potent inhibitors of kallikrein-related peptidase 6 with on-target cellular activity. Journal of Medicinal Chemistry. PMID 30212625 DOI: 10.1021/Acs.Jmedchem.8B01106  0.397
2018 Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann H. Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions. Chembiochem : a European Journal of Chemical Biology. PMID 30129686 DOI: 10.1002/Cbic.201800406  0.373
2018 Benns HJ, Tate EW, Child MA. Activity-Based Protein Profiling for the Study of Parasite Biology. Current Topics in Microbiology and Immunology. PMID 30105424 DOI: 10.1007/82_2018_123  0.368
2018 Mousnier A, Bell AS, Swieboda DP, Morales-Sanfrutos J, Pérez-Dorado I, Brannigan JA, Newman J, Ritzefeld M, Hutton JA, Guedán A, Asfor AS, Robinson SW, Hopkins-Navratilova I, Wilkinson AJ, Johnston SL, ... ... Tate EW, et al. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nature Chemistry. PMID 29760414 DOI: 10.1038/S41557-018-0039-2  0.617
2018 Beard R, Stucki A, Schmitt M, Py G, Grundschober C, Gee AD, Tate EW. Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs. Bioorganic & Medicinal Chemistry. PMID 29602673 DOI: 10.1016/J.Bmc.2018.03.019  0.324
2018 Craven G, Affron D, Allen C, Matthies S, Greener J, Morgan R, Tate E, Armstrong A, Mann DJ. High-Throughput Kinetic Analysis for Target-Directed Covalent Ligand Discovery. Angewandte Chemie (International Ed. in English). PMID 29480525 DOI: 10.1002/Anie.201711825  0.567
2018 Lubin AS, Zubiaurre AR, Matthews H, Baumann H, Fisher FR, Morales-Sanfrutos J, Hadavizadeh KS, Nardella F, Tate EW, Baum J, Scherf A, Fuchter MJ. Development of a Photo-crosslinkable Diaminoquinazoline Inhibitor for Target Identification in Plasmodium Falciparum. Acs Infectious Diseases. PMID 29377668 DOI: 10.1021/Acsinfecdis.7B00228  0.386
2018 Schlott AC, Holder AA, Tate EW. N-myristoylation as a drug target in malaria: exploring the role of N-myristoyltransferase substrates in inhibitor mode of action. Acs Infectious Diseases. PMID 29363940 DOI: 10.1021/Acsinfecdis.7B00203  0.425
2018 Mayclin S, Schlott A, Reers A, Coburn-Flynn O, Holder A, Bell A, Fidock D, Tate E. Structural insights on three series of anti-malarial N-myristoyltransferase inhibitors Acta Crystallographica Section a Foundations and Advances. 74: a428-a428. DOI: 10.1107/S0108767318095727  0.341
2017 Goncalves V, Brannigan JA, Laporte A, Bell AS, Roberts SM, Wilkinson AJ, Leatherbarrow RJ, Tate EW. Structure-guided optimization of quinoline inhibitors of Plasmodium N-myristoyltransferase. Medchemcomm. 8: 191-197. PMID 28626547 DOI: 10.1039/C6Md00531D  0.644
2017 Lanyon-Hogg T, Faronato M, Serwa RA, Tate EW. Dynamic Protein Acylation: New Substrates, Mechanisms, and Drug Targets. Trends in Biochemical Sciences. PMID 28602500 DOI: 10.1016/J.Tibs.2017.04.004  0.386
2017 Clulow JA, Storck EM, Lanyon-Hogg T, Kalesh KA, Jones LH, Tate EW. Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chemical Communications (Cambridge, England). PMID 28439590 DOI: 10.1039/C6Cc08797C  0.339
2017 Ritzefeld M, Wright MH, Tate EW. New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness. Parasitology. 1-18. PMID 28270257 DOI: 10.1017/S0031182017000282  0.392
2016 Rodgers UR, Lanyon-Hogg T, Masumoto N, Ritzefeld M, Burke R, Blagg J, Magee AI, Tate EW. Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells. Acs Chemical Biology. PMID 27779865 DOI: 10.1021/Acschembio.6B00896  0.366
2016 Ward JA, McLellan L, Stockley M, Gibson KR, Whitlock GA, Knights C, Harrigan JA, Jacq X, Tate EW. Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. Acs Chemical Biology. PMID 27779380 DOI: 10.1021/Acschembio.6B00766  0.391
2016 Zhao W, Jamshidiha M, Lanyon-Hogg T, Recchi C, Cota E, Tate EW. Direct Targeting of the Ras GTPase Superfamily through Structure-Based Design. Current Topics in Medicinal Chemistry. PMID 27530972 DOI: 10.2174/1568026616666160719165633  0.313
2016 Wright MH, Paape D, Price HP, Smith DF, Tate EW. Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei. Acs Infectious Diseases. 2: 427-441. PMID 27331140 DOI: 10.1021/Acsinfecdis.6B00034  0.396
2016 Thinon E, Morales-Sanfrutos J, Mann DJ, Tate EW. N-Myristoyltransferase Inhibition Induces ER-Stress, Cell Cycle Arrest, and Apoptosis in Cancer Cells. Acs Chemical Biology. PMID 27267252 DOI: 10.1021/Acschembio.6B00371  0.389
2016 Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW. Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase. Data in Brief. 7: 257-81. PMID 27077078 DOI: 10.1016/J.Dib.2016.02.012  0.348
2016 Albrow VE, Grimley RL, Clulow J, Rose CR, Sun J, Warmus JS, Tate EW, Jones LH, Storer RI. Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling. Molecular Biosystems. PMID 27021930 DOI: 10.1039/C6Mb00109B  0.34
2016 So EC, Schroeder GN, Carson D, Mattheis C, Mousnier A, Broncel M, Tate EW, Frankel G. The Rab-binding profiles of bacterial virulence factors during infection. The Journal of Biological Chemistry. PMID 26755725 DOI: 10.1074/Jbc.M115.700930  0.32
2015 Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase. Medchemcomm. 6: 1767-1772. PMID 26962430 DOI: 10.1039/C5Md00242G  0.657
2015 Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase. Medchemcomm. 6: 1761-1766. PMID 26962429 DOI: 10.1039/C5Md00241A  0.653
2015 Broncel M, Serwa RA, Bunney TD, Katan M, Tate EW. Global profiling of HYPE mediated AMPylation through a chemical proteomic approach. Molecular & Cellular Proteomics : McP. PMID 26604261 DOI: 10.1074/Mcp.O115.054429  0.376
2015 Charlton TM, Kovacs-Simon A, Michell SL, Fairweather NF, Tate EW. Quantitative Lipoproteomics in Clostridium difficile Reveals a Role for Lipoproteins in Sporulation. Chemistry & Biology. 22: 1562-73. PMID 26584780 DOI: 10.1016/J.Chembiol.2015.10.006  0.305
2015 Perdios L, Bunney TD, Warren SC, Dunsby C, French PM, Tate EW, Katan M. Time-resolved FRET reports FGFR1 dimerization and formation of a complex with its effector PLCγ1. Advances in Biological Regulation. PMID 26482290 DOI: 10.1016/J.Jbior.2015.09.002  0.322
2015 Lanyon-Hogg T, Masumoto N, Bodakh G, Konitsiotis AD, Thinon E, Rodgers UR, Owens RJ, Magee AI, Tate EW. Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase. Analytical Biochemistry. 490: 66-72. PMID 26334609 DOI: 10.1016/J.Ab.2015.08.025  0.377
2015 Serwa RA, Abaitua F, Krause E, Tate EW, O'Hare P. Systems Analysis of Protein Fatty Acylation in Herpes Simplex Virus-Infected Cells Using Chemical Proteomics. Chemistry & Biology. 22: 1008-17. PMID 26256475 DOI: 10.1016/J.Chembiol.2015.06.024  0.322
2015 Nickel S, Serwa RA, Kaschani F, Ninck S, Zweerink S, Tate EW, Kaiser M. Chemoproteomic Evaluation of the Polyacetylene Callyspongynic Acid. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26079733 DOI: 10.1002/Chem.201500934  0.362
2015 Ciepla P, Magee AI, Tate EW. Cholesterylation: a tail of hedgehog. Biochemical Society Transactions. 43: 262-7. PMID 25849927 DOI: 10.1042/Bst20150032  0.367
2015 Masumoto N, Lanyon-Hogg T, Rodgers UR, Konitsiotis AD, Magee AI, Tate EW. Membrane bound O-acyltransferases and their inhibitors. Biochemical Society Transactions. 43: 246-52. PMID 25849925 DOI: 10.1042/Bst20150018  0.323
2015 Broncel M, Serwa RA, Ciepla P, Krause E, Dallman MJ, Magee AI, Tate EW. Multifunctional reagents for quantitative proteome-wide analysis of protein modification in human cells and dynamic profiling of protein lipidation during vertebrate development. Angewandte Chemie (International Ed. in English). 54: 5948-51. PMID 25807930 DOI: 10.1002/Anie.201500342  0.319
2015 Wright MH, Paape D, Storck EM, Serwa RA, Smith DF, Tate EW. Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani. Chemistry & Biology. 22: 342-54. PMID 25728269 DOI: 10.1016/J.Chembiol.2015.01.003  0.407
2015 Lanyon-Hogg T, Ritzefeld M, Masumoto N, Magee AI, Rzepa HS, Tate EW. Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines. The Journal of Organic Chemistry. 80: 4370-7. PMID 25713927 DOI: 10.1021/Acs.Joc.5B00205  0.338
2015 Kalesh KA, Clulow JA, Tate EW. Target profiling of zerumbone using a novel cell-permeable clickable probe and quantitative chemical proteomics. Chemical Communications (Cambridge, England). 51: 5497-500. PMID 25598414 DOI: 10.1039/C4Cc09527H  0.35
2015 Konitsiotis AD, Jovanovi? B, Ciepla P, Spitaler M, Lanyon-Hogg T, Tate EW, Magee AI. Topological analysis of Hedgehog acyltransferase, a multipalmitoylated transmembrane protein. The Journal of Biological Chemistry. 290: 3293-307. PMID 25505265 DOI: 10.1074/Jbc.M114.614578  0.365
2015 Tate EW, Kalesh KA, Lanyon-Hogg T, Storck EM, Thinon E. Global profiling of protein lipidation using chemical proteomic technologies. Current Opinion in Chemical Biology. 24: 48-57. PMID 25461723 DOI: 10.1016/J.Cbpa.2014.10.016  0.313
2015 Douse CH, Vrielink N, Wenlin Z, Cota E, Tate EW. Targeting a dynamic protein-protein interaction: fragment screening against the malaria myosin A motor complex. Chemmedchem. 10: 134-43. PMID 25367834 DOI: 10.1002/Cmdc.201402357  0.372
2015 Yu Z, Brannigan JA, Rangachari K, Heal WP, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Discovery of pyridyl-based inhibitors of Plasmodium falciparum N-myristoyltransferase Medchemcomm. 6: 1767-1772. DOI: 10.1039/c5md00242g  0.588
2015 Rackham MD, Yu Z, Brannigan JA, Heal WP, Paape D, Barker KV, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase Medchemcomm. 6: 1761-1766. DOI: 10.1039/c5md00241a  0.587
2014 Ciepla P, Konitsiotis AD, Serwa RA, Masumoto N, Leong WP, Dallman MJ, Magee AI, Tate EW. New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish. Chemical Science (Royal Society of Chemistry : 2010). 5: 4249-4259. PMID 25574372 DOI: 10.1039/C4Sc01600A  0.338
2014 Paape D, Bell AS, Heal WP, Hutton JA, Leatherbarrow RJ, Tate EW, Smith DF. Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes. Plos Neglected Tropical Diseases. 8: e3363. PMID 25522361 DOI: 10.1371/Journal.Pntd.0003363  0.646
2014 Bunney TD, Cole AR, Broncel M, Esposito D, Tate EW, Katan M. Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. Structure (London, England : 1993). 22: 1831-43. PMID 25435325 DOI: 10.1016/J.Str.2014.10.007  0.324
2014 Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW. Global profiling of co- and post-translationally N-myristoylated proteomes in human cells. Nature Communications. 5: 4919. PMID 25255805 DOI: 10.1038/Ncomms5919  0.391
2014 Hutton JA, Goncalves V, Brannigan JA, Paape D, Wright MH, Waugh TM, Roberts SM, Bell AS, Wilkinson AJ, Smith DF, Leatherbarrow RJ, Tate EW. Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors. Journal of Medicinal Chemistry. 57: 8664-70. PMID 25238611 DOI: 10.1021/Jm5011397  0.649
2014 Olaleye TO, Brannigan JA, Roberts SM, Leatherbarrow RJ, Wilkinson AJ, Tate EW. Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites. Organic & Biomolecular Chemistry. 12: 8132-7. PMID 25230674 DOI: 10.1039/C4Ob01669F  0.65
2014 Douse CH, Maas SJ, Thomas JC, Garnett JA, Sun Y, Cota E, Tate EW. Crystal structures of stapled and hydrogen bond surrogate peptides targeting a fully buried protein-helix interaction. Acs Chemical Biology. 9: 2204-9. PMID 25084543 DOI: 10.1021/Cb500271C  0.33
2014 Brannigan JA, Roberts SM, Bell AS, Hutton JA, Hodgkinson MR, Tate EW, Leatherbarrow RJ, Smith DF, Wilkinson AJ. Diverse modes of binding in structures of Leishmania major N-myristoyltransferase with selective inhibitors. Iucrj. 1: 250-60. PMID 25075346 DOI: 10.1107/S2052252514013001  0.655
2014 Guttery DS, Poulin B, Ramaprasad A, Wall RJ, Ferguson DJ, Brady D, Patzewitz EM, Whipple S, Straschil U, Wright MH, Mohamed AM, Radhakrishnan A, Arold ST, Tate EW, Holder AA, et al. Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation. Cell Host & Microbe. 16: 128-40. PMID 25011111 DOI: 10.1016/J.Chom.2014.05.020  0.342
2014 Kalesh KA, Tate EW. A succinyl lysine-based photo-cross-linking peptide probe for Sirtuin 5. Organic & Biomolecular Chemistry. 12: 4310-3. PMID 24848608 DOI: 10.1039/C4Ob00773E  0.314
2014 Gray K, Elghadban S, Thongyoo P, Owen KA, Szabo R, Bugge TH, Tate EW, Leatherbarrow RJ, Ellis V. Potent and specific inhibition of the biological activity of the type-II transmembrane serine protease matriptase by the cyclic microprotein MCoTI-II. Thrombosis and Haemostasis. 112: 402-11. PMID 24696092 DOI: 10.1160/Th13-11-0895  0.613
2014 Rackham MD, Brannigan JA, Rangachari K, Meister S, Wilkinson AJ, Holder AA, Leatherbarrow RJ, Tate EW. Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP). Journal of Medicinal Chemistry. 57: 2773-88. PMID 24641010 DOI: 10.1021/Jm500066B  0.649
2014 Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, ... ... Tate EW, et al. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nature Chemistry. 6: 112-21. PMID 24451586 DOI: 10.1038/Nchem.1830  0.662
2014 Tate EW, Bell AS, Rackham MD, Wright MH. N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis. Parasitology. 141: 37-49. PMID 23611109 DOI: 10.1017/S0031182013000450  0.407
2014 Thinon E, Serwa RA, Broncel M, Brannigan JA, Brassat U, Wright MH, Heal WP, Wilkinson AJ, Mann DJ, Tate EW. Chemical Proteomics Defines the Mammalian N- Myristoylated Proteome in Live Cells Global Profiling of Co- and Post-Translationally N-Myristoylated Proteomes in Human Cells. Nature Communications. 5: 4919. DOI: 10.2210/Pdb4C2Z/Pdb  0.318
2014 Magee A, Konitsiotis A, Jovanovic B, Chang S, Ciepla P, Masumoto N, Tate E. Lipidation of Hedgehog proteins: function, enzymology and therapeutic potential in pancreatic cancer Pancreatology. 14: e4. DOI: 10.1016/J.Pan.2014.03.013  0.372
2013 Poulin B, Patzewitz EM, Brady D, Silvie O, Wright MH, Ferguson DJ, Wall RJ, Whipple S, Guttery DS, Tate EW, Wickstead B, Holder AA, Tewari R. Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite. Biology Open. 2: 1160-70. PMID 24244852 DOI: 10.1242/Bio.20136163  0.332
2013 Storck EM, Serwa RA, Tate EW. Chemical proteomics: a powerful tool for exploring protein lipidation. Biochemical Society Transactions. 41: 56-61. PMID 23356258 DOI: 10.1042/Bst20120283  0.306
2013 Rackham MD, Brannigan JA, Moss DK, Yu Z, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase. Journal of Medicinal Chemistry. 56: 371-5. PMID 23170970 DOI: 10.1021/Jm301474T  0.649
2012 Yu Z, Brannigan JA, Moss DK, Brzozowski AM, Wilkinson AJ, Holder AA, Tate EW, Leatherbarrow RJ. Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. Journal of Medicinal Chemistry. 55: 8879-90. PMID 23035716 DOI: 10.1021/Jm301160H  0.662
2012 Price HP, Hodgkinson MR, Wright MH, Tate EW, Smith BA, Carrington M, Stark M, Smith DF. A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei. Biochimica Et Biophysica Acta. 1823: 1178-91. PMID 22609302 DOI: 10.1016/J.Bbamcr.2012.05.007  0.314
2012 Bell AS, Mills JE, Williams GP, Brannigan JA, Wilkinson AJ, Parkinson T, Leatherbarrow RJ, Tate EW, Holder AA, Smith DF. Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs. Plos Neglected Tropical Diseases. 6: e1625. PMID 22545171 DOI: 10.1371/Journal.Pntd.0001625  0.64
2012 Goncalves V, Brannigan JA, Whalley D, Ansell KH, Saxty B, Holder AA, Wilkinson AJ, Tate EW, Leatherbarrow RJ. Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode. Journal of Medicinal Chemistry. 55: 3578-82. PMID 22439843 DOI: 10.1021/Jm300040P  0.649
2012 Heal WP, Wright MH, Thinon E, Tate EW. Multifunctional protein labeling via enzymatic N-terminal tagging and elaboration by click chemistry. Nature Protocols. 7: 105-17. PMID 22193303 DOI: 10.1038/Nprot.2011.425  0.399
2012 Heal WP, Tate EW. Application of activity-based protein profiling to the study of microbial pathogenesis. Topics in Current Chemistry. 324: 115-35. PMID 22102218 DOI: 10.1007/128_2011_299  0.317
2012 Goncalves V, Brannigan JA, Thinon E, Olaleye TO, Serwa R, Lanzarone S, Wilkinson AJ, Tate EW, Leatherbarrow RJ. A fluorescence-based assay for N-myristoyltransferase activity. Analytical Biochemistry. 421: 342-4. PMID 22051857 DOI: 10.1016/J.Ab.2011.10.013  0.631
2012 Tam Dang TH, Fagan RP, Fairweather NF, Tate EW. Novel inhibitors of surface layer processing in Clostridium difficile. Bioorganic & Medicinal Chemistry. 20: 614-21. PMID 21752656 DOI: 10.1016/J.Bmc.2011.06.042  0.332
2012 Bradshaw RT, Aronica PGA, Tate EW, Leatherbarrow RJ, Gould IR. Mutational Locally Enhanced Sampling (MULES) for quantitative prediction of the effects of mutations at protein-protein interfaces Chemical Science. 3: 1503-1511. DOI: 10.1039/C2Sc00895E  0.552
2011 de la Riva L, Willing SE, Tate EW, Fairweather NF. Roles of cysteine proteases Cwp84 and Cwp13 in biogenesis of the cell wall of Clostridium difficile. Journal of Bacteriology. 193: 3276-85. PMID 21531808 DOI: 10.1128/Jb.00248-11  0.304
2011 Serwa R, Tate EW. Activity-based profiling for drug discovery. Chemistry & Biology. 18: 407-9. PMID 21513874 DOI: 10.1016/J.Chembiol.2011.04.002  0.333
2011 Heal WP, Jovanovic B, Bessin S, Wright MH, Magee AI, Tate EW. Bioorthogonal chemical tagging of protein cholesterylation in living cells. Chemical Communications (Cambridge, England). 47: 4081-3. PMID 21221452 DOI: 10.1039/C0Cc04710D  0.323
2011 Heal WP, Dang TH, Tate EW. Activity-based probes: discovering new biology and new drug targets. Chemical Society Reviews. 40: 246-57. PMID 20886146 DOI: 10.1039/C0Cs00004C  0.337
2011 Bradshaw RT, Patel BH, Tate EW, Leatherbarrow RJ, Gould IR. Comparing experimental and computational alanine scanning techniques for probing a prototypical protein-protein interaction. Protein Engineering, Design & Selection : Peds. 24: 197-207. PMID 20656696 DOI: 10.1093/Protein/Gzq047  0.608
2010 So S, Peeva LG, Tate EW, Leatherbarrow RJ, Livingston AG. Membrane enhanced peptide synthesis. Chemical Communications (Cambridge, England). 46: 2808-10. PMID 20369190 DOI: 10.1039/B926747F  0.565
2010 Heal WP, Tate EW. Getting a chemical handle on protein post-translational modification. Organic & Biomolecular Chemistry. 8: 731-8. PMID 20135026 DOI: 10.1039/B917894E  0.332
2010 Dang TH, de la Riva L, Fagan RP, Storck EM, Heal WP, Janoir C, Fairweather NF, Tate EW. Chemical probes of surface layer biogenesis in Clostridium difficile. Acs Chemical Biology. 5: 279-85. PMID 20067320 DOI: 10.1021/Cb9002859  0.308
2010 Brannigan JA, Smith BA, Yu Z, Brzozowski AM, Hodgkinson MR, Maroof A, Price HP, Meier F, Leatherbarrow RJ, Tate EW, Smith DF, Wilkinson AJ. N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis. Journal of Molecular Biology. 396: 985-99. PMID 20036251 DOI: 10.1016/J.Jmb.2009.12.032  0.664
2010 Wright MH, Heal WP, Mann DJ, Tate EW. Protein myristoylation in health and disease. Journal of Chemical Biology. 3: 19-35. PMID 19898886 DOI: 10.1007/S12154-009-0032-8  0.426
2010 So S, Peeva LG, Tate EW, Leatherbarrow RJ, Livingston AG. Organic solvent nanofiltration: A new paradigm in peptide synthesis Organic Process Research and Development. 14: 1313-1325. DOI: 10.1021/Op1001403  0.577
2010 Dixon DJ, Ley SV, Tate EW. ChemInform Abstract: Highly cis- or trans-Selective Oxygen to Carbon Rearrangements of Anomerically Linked 6-Substituted Tetrahydropyranyl Enol Ethers. Cheminform. 31: no-no. DOI: 10.1002/chin.200004150  0.551
2010 DIXON DJ, LEY SV, TATE EW. ChemInform Abstract: A Total Synthesis of (+)-Goniodiol Using an Anomeric Oxygen-to-Carbon Rearrangement. Cheminform. 30: no-no. DOI: 10.1002/chin.199911276  0.551
2010 DIXON DJ, LEY SV, TATE EW. ChemInform Abstract: Diastereoselective Anomeric Oxygen to Carbon Rearrangements of Silyl Enol Ether Derivatives of Lactols. Cheminform. 30: no-no. DOI: 10.1002/chin.199904137  0.546
2010 BUFFET MF, DIXON DJ, LEY SV, TATE EW. ChemInform Abstract: Anomeric Oxygen to Carbon Rearrangements of Alkynyl Tributylstannane Derivatives of Lactols. Cheminform. 30: no-no. DOI: 10.1002/chin.199904136  0.542
2010 BUFFET MF, DIXON DJ, EDWARDS GL, LEY SV, TATE E. ChemInform Abstract: A General C-Glycosidation Procedure via Anomeric Oxygen to Carbon Rearrangements of Tetrahydropyranyl Ether Derivatives. Cheminform. 29: no-no. DOI: 10.1002/chin.199803144  0.54
2009 Thongyoo P, Bonomelli C, Leatherbarrow RJ, Tate EW. Potent inhibitors of beta-tryptase and human leukocyte elastase based on the MCoTI-II scaffold. Journal of Medicinal Chemistry. 52: 6197-200. PMID 19772295 DOI: 10.1021/Jm901233U  0.589
2008 Heal WP, Wickramasinghe SR, Tate EW. Activity based chemical proteomics: profiling proteases as drug targets. Current Drug Discovery Technologies. 5: 200-12. PMID 18690889 DOI: 10.2174/157016308785739866  0.404
2008 Busch GK, Tate EW, Gaffney PR, Rosivatz E, Woscholski R, Leatherbarrow RJ. Specific N-terminal protein labelling: use of FMDV 3C pro protease and native chemical ligation. Chemical Communications (Cambridge, England). 3369-71. PMID 18633492 DOI: 10.1039/B806727A  0.626
2008 Heal WP, Wickramasinghe SR, Leatherbarrow RJ, Tate EW. N-Myristoyl transferase-mediated protein labelling in vivo. Organic & Biomolecular Chemistry. 6: 2308-15. PMID 18563263 DOI: 10.1039/B803258K  0.633
2008 Thongyoo P, Roqué-Rosell N, Leatherbarrow RJ, Tate EW. Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides. Organic & Biomolecular Chemistry. 6: 1462-70. PMID 18385853 DOI: 10.1039/B801667D  0.63
2008 Bowyer PW, Tate EW, Leatherbarrow RJ, Holder AA, Smith DF, Brown KA. N-myristoyltransferase: a prospective drug target for protozoan parasites. Chemmedchem. 3: 402-8. PMID 18324715 DOI: 10.1002/Cmdc.200700301  0.609
2008 Heal WP, Wickramasinghe SR, Bowyer PW, Holder AA, Smith DF, Leatherbarrow RJ, Tate EW. Site-specific N-terminal labelling of proteins in vitro and in vivo using N-myristoyl transferase and bioorthogonal ligation chemistry. Chemical Communications (Cambridge, England). 480-2. PMID 18188474 DOI: 10.1039/B716115H  0.624
2007 Bowyer PW, Gunaratne RS, Grainger M, Withers-Martinez C, Wickramsinghe SR, Tate EW, Leatherbarrow RJ, Brown KA, Holder AA, Smith DF. Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum. The Biochemical Journal. 408: 173-80. PMID 17714074 DOI: 10.1042/Bj20070692  0.629
2007 Thongyoo P, Jaulent AM, Tate EW, Leatherbarrow RJ. Immobilized protease-assisted synthesis of engineered cysteine-knot microproteins. Chembiochem : a European Journal of Chemical Biology. 8: 1107-9. PMID 17526063 DOI: 10.1002/Cbic.200700187  0.565
2006 Thongyoo P, Tate EW, Leatherbarrow RJ. Total synthesis of the macrocyclic cysteine knot microprotein MCoTI-II. Chemical Communications (Cambridge, England). 2848-50. PMID 17007393 DOI: 10.1039/B607324G  0.602
2006 Tate EW, Dixon DJ, Ley SV. A highly enantioselective total synthesis of (+)-goniodiol. Organic & Biomolecular Chemistry. 4: 1698-706. PMID 16633562 DOI: 10.1039/B602805E  0.605
2006 Tate EW, Bowyer PW, Brown KA, Smith DF, Holder AA, Leatherbarrow RJ. Peptide-based inhibitors of N-myristoyl transferase generated from a lipid/combinatorial peptide chimera library Signal Transduction. 6: 160-166. DOI: 10.1002/Sita.200500084  0.628
2006 Tate EW. Chemical intervention in signalling networks: Recent advances and applications Signal Transduction. 6: 144-159. DOI: 10.1002/Sita.200500075  0.312
2002 Kalaï C, Tate E, Zard SZ. A short formal route to (±)-lepadin B using a xanthate-mediated free radical cyclisation/vinylation sequence Chemical Communications. 1430-1431. DOI: 10.1039/B203604E  0.348
2002 Tate EW, Zard SZ. Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition and Mannich cyclisation cascade Tetrahedron Letters. 43: 4683-4686. DOI: 10.1016/S0040-4039(02)00835-3  0.401
2000 Dixon DJ, Ley SV, Tate EW. Diastereoselective oxygen to carbon rearrangements of anomerically linked enol ethers and the total synthesis of (+)-(S,S)-cis-6-methyltetrahydropyran-2-ylacetic acid, a component of civet Journal of the Chemical Society, Perkin Transactions 1. 2385-2394. DOI: 10.1039/B001243M  0.604
2000 Dixon DJ, Ley SV, Tate EW. The synthesis of mono- and bicyclic ethers via acid catalysed ring-opening cyclisation of tetrahyclropyranyl ether derivatives Journal of the Chemical Society, Perkin Transactions 1. 1829-1836. DOI: 10.1039/A909302H  0.524
2000 Buffet MF, Dixon DJ, Edwards GL, Ley SV, Tate EW. Oxygen to carbon rearrangements of anomerically linked alkenols from tetrahydropyran derivatives: An investigation of the reaction mechanism via a double isotopic labelling crossover study Journal of the Chemical Society, Perkin Transactions 1. 1815-1827. DOI: 10.1039/A909300A  0.555
2000 Dixon DJ, Ley SV, Tate EW. ChemInform Abstract: Diastereoselective Oxygen to Carbon Rearrangements of Anomerically Linked Enol Ethers and the Total Synthesis of (+)-(S,S)-(cis-6-Methyltetrahydropyran-2-yl)acetic Acid, a Component of Civet. Cheminform. 31: no-no. DOI: 10.1002/chin.200048060  0.544
2000 Dixon DJ, Ley SV, Tate EW. ChemInform Abstract: The Synthesis of Mono- and Bicyclic Ethers via Acid-Catalyzed Ring-Opening Cyclization of Tetrahydropyranyl Ether Derivatives. Cheminform. 31: no-no. DOI: 10.1002/chin.200041107  0.528
2000 Buffet MF, Dixon DJ, Edwards GL, Ley SV, Tate EW. ChemInform Abstract: Oxygen to Carbon Rearrangements of Anomerically Linked Alkenols from Tetrahydropyran Derivatives: An Investigation of the Reaction Mechanism via a Double Isotopic Labeling Crossover Study. Cheminform. 31: no-no. DOI: 10.1002/chin.200041106  0.541
1999 Dixon DJ, Ley SV, Tate EW. Highly cis- or trans-selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers Journal of the Chemical Society-Perkin Transactions 1. 2665-2667. DOI: 10.1039/A904891J  0.594
1999 Dixon DJ, Ley SV, Tate EW. Highly cis- or fraws-selective oxygen to carbon rearrangements of anomerically linked 6-substituted tetrahydropyranyl enol ethers Journal of the Chemical Society - Perkin Transactions 1. 2665-2667.  0.479
1998 Dixon DJ, Ley SV, Tate EW. Diastereoselective Anomeric Oxygen to Carbon Rearrangements of Silyl Enol Ether Derivatives of Lactols Synlett. 1998: 1093-1095. DOI: 10.1055/S-1998-1867  0.586
1998 Buffet MF, Dixon DJ, Ley SV, Tate EW. Anomeric Oxygen to Carbon Rearrangements of Alkynyl Tributylstannane Derivatives of Lactols Synlett. 1998: 1091-1092. DOI: 10.1055/S-1998-1866  0.582
1998 Dixon DJ, Ley SV, Tate EW. A total synthesis of (+)-Goniodiol using an anomeric oxygen-to-carbon rearrangement Journal of the Chemical Society-Perkin Transactions 1. 3125-3126. DOI: 10.1039/A806584E  0.591
1998 Dixon DJ, Ley SV, Tate EW. A total synthesis of (+)-Goniodiol using an anomeric oxygen-to-carbon rearrangement Journal of the Chemical Society - Perkin Transactions 1. 3125-3126.  0.476
1997 Buffet M, Dixon D, Edwards G, Ley S, Tate E. A General C-Glycosidation Procedure via Anomeric Oxygen to Carbon Rearrangements of Tetrahydropyranyl Ether Derivatives Synlett. 1997: 1055-1056. DOI: 10.1055/S-1997-1531  0.581
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