| Year |
Citation |
Score |
| 2023 |
Tucci P, Brown I, Bewick GS, Pertwee RG, Marini P. The Plant Derived 3-3'-Diindolylmethane (DIM) Behaves as CB Receptor Agonist in Prostate Cancer Cellular Models. International Journal of Molecular Sciences. 24. PMID 36835033 DOI: 10.3390/ijms24043620 |
0.318 |
|
| 2023 |
Marini P, Cowie P, Ayar A, Bewick GS, Barrow J, Pertwee RG, MacKenzie A, Tucci P. M3 Receptor Pathway Stimulates Rapid Transcription of the CB1 Receptor Activation through Calcium Signalling and the CNR1 Gene Promoter. International Journal of Molecular Sciences. 24. PMID 36674826 DOI: 10.3390/ijms24021308 |
0.349 |
|
| 2022 |
Brandt AL, Garai S, Zagzoog A, Hurst DP, Stevenson LA, Pertwee RG, Imler GH, Reggio PH, Thakur GA, Laprairie RB. Pharmacological evaluation of enantiomerically separated positive allosteric modulators of cannabinoid 1 receptor, GAT591 and GAT593. Frontiers in Pharmacology. 13: 919605. PMID 36386195 DOI: 10.3389/fphar.2022.919605 |
0.335 |
|
| 2022 |
Ferrisi R, Gado F, Polini B, Ricardi C, Mohamed KA, Stevenson LA, Ortore G, Rapposelli S, Saccomanni G, Pertwee RG, Laprairie RB, Manera C, Chiellini G. Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CBR). Frontiers in Chemistry. 10: 984069. PMID 36238097 DOI: 10.3389/fchem.2022.984069 |
0.314 |
|
| 2022 |
Marini P, Cascio MG, Pertwee RG. Cyclic AMP Assay Using Human Cannabinoid CB Receptor-Transfected Cells. Methods in Molecular Biology (Clifton, N.J.). 2576: 171-179. PMID 36152185 DOI: 10.1007/978-1-0716-2728-0_13 |
0.38 |
|
| 2022 |
Cascio MG, Marini P, Pertwee RG. Displacement Binding Assay Using Human Cannabinoid CB Receptor-Transfected Cells. Methods in Molecular Biology (Clifton, N.J.). 2576: 111-118. PMID 36152180 DOI: 10.1007/978-1-0716-2728-0_8 |
0.317 |
|
| 2022 |
Gorberg V, Borisov V, Greig IR, Pertwee RG, McCaffery P, Anavi-Goffer S. Motor-like Tics are Mediated by CB Cannabinoid Receptor-dependent and Independent Mechanisms Associated with Age and Sex. Molecular Neurobiology. PMID 35666403 DOI: 10.1007/s12035-022-02884-6 |
0.378 |
|
| 2021 |
Gado F, Ceni C, Ferrisi R, Sbrana G, Stevenson LA, Macchia M, Pertwee RG, Bertini S, Manera C, Ortore G. CB1 receptor binding sites for NAM and PAM: A first approach for studying, new n‑butyl‑diphenylcarboxamides as allosteric modulators. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 169: 106088. PMID 34863873 DOI: 10.1016/j.ejps.2021.106088 |
0.306 |
|
| 2020 |
Meini S, Gado F, Stevenson LA, Digiacomo M, Saba A, Codini S, Macchia M, Pertwee RG, Bertini S, Manera C. PSNCBAM-1 analogs: Structural evolutions and allosteric properties at cannabinoid CB1 receptor. European Journal of Medicinal Chemistry. 203: 112606. PMID 32682199 DOI: 10.1016/J.Ejmech.2020.112606 |
0.432 |
|
| 2020 |
Brizzi A, Aiello F, Boccella S, Cascio MG, De Petrocellis L, Frosini M, Gado F, Ligresti A, Luongo L, Marini P, Mugnaini C, Pessina F, Corelli F, Maione S, Manera C, ... Pertwee RG, et al. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity. Bioorganic & Medicinal Chemistry. 115513. PMID 32340793 DOI: 10.1016/J.Bmc.2020.115513 |
0.52 |
|
| 2019 |
Garai S, Kulkarni PM, Schaffer PC, Leo L, Brandt AL, Zagzoog A, Black T, Lin X, Hurst DP, Janero DR, Abood ME, Zimmowitch A, Straiker A, Pertwee RG, Kelly M, et al. Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of CB1 Receptor Positive Allosteric Modulators. Journal of Medicinal Chemistry. PMID 31756109 DOI: 10.1021/Acs.Jmedchem.9B01142 |
0.44 |
|
| 2019 |
Laprairie RB, Mohamed KA, Zagzoog A, Kelly MEM, Stevenson LA, Pertwee R, Denovan-Wright EM, Thakur GA. Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling. Frontiers in Molecular Neuroscience. 12: 257. PMID 31680861 DOI: 10.3389/Fnmol.2019.00257 |
0.42 |
|
| 2019 |
Brown I, Lee J, Sneddon AA, Cascio MG, Pertwee RG, Wahle KWJ, Rotondo D, Heys SD. Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 102024. PMID 31679810 DOI: 10.1016/J.Plefa.2019.102024 |
0.316 |
|
| 2019 |
Hay EA, Cowie P, McEwan AR, Ross R, Pertwee RG, MacKenzie A. Disease associated polymorphisms within the conserved ECR1 enhancer differentially regulate the tissue specific activity of the cannabinoid-1 receptor gene promoter; implications for cannabinoid pharmacogenetics. Human Mutation. PMID 31608546 DOI: 10.1002/Humu.23931 |
0.34 |
|
| 2019 |
Xi ZX, Muldoon P, Wang XF, Bi GH, Damaj MI, Lichtman AH, Pertwee RG, Gardner EL. Δ -Tetrahydrocannabivarin has potent anti-nicotine effects in multiple rodent models of nicotine dependence. British Journal of Pharmacology. PMID 31454413 DOI: 10.1111/Bph.14844 |
0.488 |
|
| 2019 |
Hay EA, McEwan A, Wilson D, Barrett P, D'Agostino G, Pertwee RG, MacKenzie A. Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour. Psychoneuroendocrinology. 109: 104407. PMID 31445429 DOI: 10.1016/J.Psyneuen.2019.104407 |
0.326 |
|
| 2019 |
Abood M, Alexander SP, Barth F, Bonner TI, Bradshaw H, Cabral G, Casellas P, Cravatt BF, Devane WA, Di Marzo V, Elphick MR, Felder CC, Greasley P, Herkenham M, Howlett AC, ... ... Pertwee RG, et al. Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f13/2019.4 |
0.43 |
|
| 2019 |
Alcina AG, Stevenson LA, Haj C, Smoum R, Mechoulam R, Hislop JN, Pertwee RG. A synthetic analogue of cannabidiolic acid that acts like a positive allosteric modulator at 5-HT1A receptors British Journal of Pharmacology. 176: 3011-3012. DOI: 10.1111/Bph.14681 |
0.447 |
|
| 2018 |
Gado F, Di Cesare Mannelli L, Lucarini E, Bertini S, Cappelli E, Digiacomo M, Stevenson LA, Macchia M, Tuccinardi T, Ghelardini C, Pertwee RG, Manera C. Identification of the First Synthetic Allosteric Modulator of the CB Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief. Journal of Medicinal Chemistry. PMID 29990428 DOI: 10.1021/Acs.Jmedchem.8B00368 |
0.423 |
|
| 2018 |
Dolles D, Strasser A, Wittmann H, Marinelli O, Nabissi M, Pertwee RG, Decker M. The First Photochromic Affinity Switch for the Human Cannabinoid Receptor 2 (Adv. Therap. 1/2018) Advanced Therapeutics. 1: 1870003. DOI: 10.1002/adtp.201870003 |
0.318 |
|
| 2018 |
Dolles D, Strasser A, Wittmann H, Marinelli O, Nabissi M, Pertwee RG, Decker M. The First Photochromic Affinity Switch for the Human Cannabinoid Receptor 2 Advanced Therapeutics. 1: 1700032. DOI: 10.1002/adtp.201700032 |
0.32 |
|
| 2017 |
Pertwee RG, Rock EM, Guenther K, Limebeer CL, Stevenson LA, Haj C, Smoum R, Parker LA, Mechoulam R. Cannabidiolic acid methyl ester, a stable synthetic analogue of cannabidiolic acid, can produce 5-HT1A receptor-mediated suppression of nausea and anxiety in rats. British Journal of Pharmacology. PMID 29057454 DOI: 10.1111/Bph.14073 |
0.392 |
|
| 2017 |
Slivicki RA, Xu Z, Kulkarni PM, Pertwee RG, Mackie K, Thakur GA, Hohmann AG. Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence. Biological Psychiatry. PMID 28823711 DOI: 10.1016/J.Biopsych.2017.06.032 |
0.401 |
|
| 2017 |
Laprairie RB, Kulkarni PM, Deschamps JR, Kelly ME, Janero DR, Cascio MG, Stevenson LA, Pertwee RG, Kenakin T, Denovan-Wright EM, Thakur GA. Enantio-specific Allosteric Modulation of Cannabinoid 1 Receptor. Acs Chemical Neuroscience. PMID 28103441 DOI: 10.1021/Acschemneuro.6B00310 |
0.482 |
|
| 2017 |
Hay E, Cowie P, Pertwee R, MacKenzie A. Exploring genetic and epigenetic variation of the cannabinoid receptor-1 gene; implications for personalised medicine Neuropeptides. 65: 134. DOI: 10.1016/J.Npep.2017.02.021 |
0.354 |
|
| 2017 |
Cascio MG, Pertwee RG, Marini P. The Pharmacology and Therapeutic Potential of Plant Cannabinoids Neuropeptides. 65: 207-225. DOI: 10.1007/978-3-319-54564-6_9 |
0.424 |
|
| 2016 |
Marini P, Cascio MG, Pertwee RG. The Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells. Methods in Molecular Biology (Clifton, N.J.). 1412: 85-93. PMID 27245894 DOI: 10.1007/978-1-4939-3539-0_9 |
0.48 |
|
| 2016 |
Cascio MG, Marini P, Pertwee RG. The Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells. Methods in Molecular Biology (Clifton, N.J.). 1412: 57-63. PMID 27245891 DOI: 10.1007/978-1-4939-3539-0_6 |
0.427 |
|
| 2016 |
Laprairie RB, Kulkarni AR, Kulkarni PM, Hurst DP, Lynch DL, Reggio PH, Janero DR, Pertwee RG, Stevenson LA, Kelly M, Denovan-Wright EM, Thakur GA. MAPPING CANNABINOID RECEPTOR 1 ALLOSTERIC SITE(S): CRITICAL MOLECULAR DETERMINANT AND SIGNALING PROFILE OF GAT100 - A NOVEL, POTENT AND IRREVERSIBLY BINDING PROBE. Acs Chemical Neuroscience. PMID 27046127 DOI: 10.1021/Acschemneuro.6B00041 |
0.466 |
|
| 2016 |
Colizzi M, McGuir P, Pertwee RG, Bhattacharyya S. EFFECT OF CANNABIS ON GLUTAMATE SIGNALLING IN THE BRAIN: A SYSTEMATIC REVIEW OF HUMAN AND ANIMAL EVIDENCE. Neuroscience and Biobehavioral Reviews. PMID 26987641 DOI: 10.1016/J.Neubiorev.2016.03.010 |
0.347 |
|
| 2016 |
Romano B, Pagano E, Orlando P, Capasso R, Cascio MG, Pertwee R, Marzo VD, Izzo AA, Borrelli F. Pure Δ9-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Δ9-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages Pharmacological Research. 113: 199-208. DOI: 10.1016/J.Phrs.2016.07.045 |
0.367 |
|
| 2015 |
Kulkarni PM, Kulkarni AR, Korde A, Tichkule RB, Laprairie RB, Denovan-Wright EM, Zhou H, Janero DR, Zvonok N, Makriyannis A, Cascio MG, Pertwee RG, Thakur GA. Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s). Journal of Medicinal Chemistry. PMID 26529344 DOI: 10.1021/Acs.Jmedchem.5B01303 |
0.43 |
|
| 2015 |
Pertwee RG. Endocannabinoids and Their Pharmacological Actions. Handbook of Experimental Pharmacology. 231: 1-37. PMID 26408156 DOI: 10.1007/978-3-319-20825-1_1 |
0.531 |
|
| 2015 |
Smoum R, Baraghithy S, Chourasia M, Breuer A, Mussai N, Attar-Namdar M, Kogan NM, Raphael B, Bolognini D, Cascio MG, Marini P, Pertwee RG, Shurki A, Mechoulam R, Bab I. CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency. Proceedings of the National Academy of Sciences of the United States of America. 112: 8774-9. PMID 26124120 DOI: 10.1073/Pnas.1503395112 |
0.456 |
|
| 2015 |
Cascio MG, Zamberletti E, Marini P, Parolaro D, Pertwee RG. The phytocannabinoid, Δ⁹-tetrahydrocannabivarin, can act through 5-HT₁A receptors to produce antipsychotic effects. British Journal of Pharmacology. 172: 1305-18. PMID 25363799 DOI: 10.1111/Bph.13000 |
0.486 |
|
| 2015 |
Goonawardena AV, Plano A, Robinson L, Ross R, Greig I, Pertwee RG, Hampson RE, Platt B, Riedel G. Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459. Behavioural Pharmacology. 26: 289-303. PMID 25356730 DOI: 10.1097/Fbp.0000000000000108 |
0.354 |
|
| 2015 |
McPartland JM, Duncan M, Di Marzo V, Pertwee RG. Are cannabidiol and Δ(9) -tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review. British Journal of Pharmacology. 172: 737-53. PMID 25257544 DOI: 10.1111/Bph.12944 |
0.547 |
|
| 2015 |
Cascio MG, Zamberletti E, Marini P, Parolaro D, Pertwee RG. The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act through 5-HT1A receptors to produce antipsychotic effects British Journal of Pharmacology. 172: 1305-1318. DOI: 10.1111/bph.13000 |
0.412 |
|
| 2015 |
Smoum R, Baraghithy S, Chourasia M, Breuer A, Mussai N, Attar-Namdar M, Kogan NM, Raphael B, Bolognini D, Cascio MG, Marini P, Pertwee RG, Shurki A, Mechoulam R, Bab I. CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency Proceedings of the National Academy of Sciences of the United States of America. 112: 8774-8779. DOI: 10.1073/pnas.1503395112 |
0.37 |
|
| 2015 |
Zanato C, Cascio MG, Lazzari P, Pertwee R, Testa A, Zanda M. Tricyclic fused pyrazoles with a 'Click' 1,2,3-triazole substituent in position 3 are nanomolar CB1 receptor ligands Synthesis (Germany). 47: 817-826. DOI: 10.1055/S-0034-1379887 |
0.42 |
|
| 2014 |
Mechoulam R, Hanuš LO, Pertwee R, Howlett AC. Early phytocannabinoid chemistry to endocannabinoids and beyond Nature Reviews Neuroscience. 15: 757-764. PMID 25315390 DOI: 10.1038/Nrn3811 |
0.345 |
|
| 2014 |
Brizzi A, Aiello F, Marini P, Cascio MG, Corelli F, Brizzi V, De Petrocellis L, Ligresti A, Luongo L, Lamponi S, Maione S, Pertwee RG, Di Marzo V. Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist. Bioorganic & Medicinal Chemistry. 22: 4770-83. PMID 25065940 DOI: 10.1016/J.Bmc.2014.07.006 |
0.522 |
|
| 2014 |
Gamage TF, Ignatowska-Jankowska BM, Wiley JL, Abdelrahman M, Trembleau L, Greig IR, Thakur GA, Tichkule R, Poklis J, Ross RA, Pertwee RG, Lichtman AH. In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569. Behavioural Pharmacology. 25: 182-5. PMID 24603340 DOI: 10.1097/Fbp.0000000000000027 |
0.521 |
|
| 2014 |
Romano B, Borrelli F, Pagano E, Cascio MG, Pertwee RG, Izzo AA. Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 21: 631-9. PMID 24373545 DOI: 10.1016/J.Phymed.2013.11.006 |
0.378 |
|
| 2014 |
Distinto R, Zanato C, Montanari S, Cascio MG, Lazzari P, Pertwee R, Zanda M. Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands Journal of Fluorine Chemistry. DOI: 10.1016/J.Jfluchem.2014.07.010 |
0.422 |
|
| 2013 |
Espejo-Porras F, Fernández-Ruiz J, Pertwee RG, Mechoulam R, García C. Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors. Neuropharmacology. 75: 155-63. PMID 23924692 DOI: 10.1016/J.Neuropharm.2013.07.024 |
0.476 |
|
| 2013 |
Hill TD, Cascio MG, Romano B, Duncan M, Pertwee RG, Williams CM, Whalley BJ, Hill AJ. Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism. British Journal of Pharmacology. 170: 679-92. PMID 23902406 DOI: 10.1111/Bph.12321 |
0.388 |
|
| 2013 |
Marini P, Cascio MG, King A, Pertwee RG, Ross RA. Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors. British Journal of Pharmacology. 169: 887-99. PMID 23711022 DOI: 10.1111/Bph.12191 |
0.513 |
|
| 2013 |
Romano B, Borrelli F, Fasolino I, Capasso R, Piscitelli F, Cascio M, Pertwee R, Coppola D, Vassallo L, Orlando P, Di Marzo V, Izzo A. The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis. British Journal of Pharmacology. 169: 213-29. PMID 23373571 DOI: 10.1111/Bph.12120 |
0.442 |
|
| 2013 |
Baillie GL, Horswill JG, Anavi-Goffer S, Reggio PH, Bolognini D, Abood ME, McAllister S, Strange PG, Stephens GJ, Pertwee RG, Ross RA. CB(1) receptor allosteric modulators display both agonist and signaling pathway specificity. Molecular Pharmacology. 83: 322-38. PMID 23160940 DOI: 10.1124/Mol.112.080879 |
0.479 |
|
| 2013 |
Bolognini D, Rock EM, Cluny NL, Cascio MG, Limebeer CL, Duncan M, Stott CG, Javid FA, Parker LA, Pertwee RG. Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. British Journal of Pharmacology. 168: 1456-70. PMID 23121618 DOI: 10.1111/Bph.12043 |
0.426 |
|
| 2013 |
Brown I, Cascio MG, Rotondo D, Pertwee RG, Heys SD, Wahle KW. Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators. Progress in Lipid Research. 52: 80-109. PMID 23103355 DOI: 10.1016/J.Plipres.2012.10.001 |
0.373 |
|
| 2013 |
Fernández-Ruiz J, Sagredo O, Pazos MR, García C, Pertwee R, Mechoulam R, Martínez-Orgado J. Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? British Journal of Clinical Pharmacology. 75: 323-33. PMID 22625422 DOI: 10.1111/J.1365-2125.2012.04341.X |
0.445 |
|
| 2012 |
Pertwee RG. Lipoxin A4 is an allosteric endocannabinoid that strengthens anandamide-induced CB1 receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 109: 20781-2. PMID 23204441 DOI: 10.1073/Pnas.1218529110 |
0.529 |
|
| 2012 |
Pertwee RG. Targeting the endocannabinoid system with cannabinoid receptor agonists: pharmacological strategies and therapeutic possibilities. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 367: 3353-63. PMID 23108552 DOI: 10.1098/Rstb.2011.0381 |
0.484 |
|
| 2012 |
Pasquini S, De Rosa M, Ligresti A, Mugnaini C, Brizzi A, Caradonna NP, Cascio MG, Bolognini D, Pertwee RG, Di Marzo V, Corelli F. Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors. European Journal of Medicinal Chemistry. 58: 30-43. PMID 23085772 DOI: 10.1016/J.Ejmech.2012.09.035 |
0.47 |
|
| 2012 |
Valdeolivas S, Satta V, Pertwee RG, Fernández-Ruiz J, Sagredo O. Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors. Acs Chemical Neuroscience. 3: 400-6. PMID 22860209 DOI: 10.1021/Cn200114W |
0.496 |
|
| 2012 |
Mugnaini C, Nocerino S, Pedani V, Pasquini S, Tafi A, De Chiaro M, Bellucci L, Valoti M, Guida F, Luongo L, Dragoni S, Ligresti A, Rosenberg A, Bolognini D, Cascio MG, ... Pertwee RG, et al. Investigations on the 4-quinolone-3-carboxylic acid motif part 5: modulation of the physicochemical profile of a set of potent and selective cannabinoid-2 receptor ligands through a bioisosteric approach. Chemmedchem. 7: 920-34. PMID 22383251 DOI: 10.1002/Cmdc.201100573 |
0.406 |
|
| 2012 |
Anavi-Goffer S, Baillie G, Irving AJ, Gertsch J, Greig IR, Pertwee RG, Ross RA. Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. The Journal of Biological Chemistry. 287: 91-104. PMID 22027819 DOI: 10.1074/Jbc.M111.296020 |
0.507 |
|
| 2012 |
Bolognini D, Cascio MG, Parolaro D, Pertwee RG. AM630 behaves as a protean ligand at the human cannabinoid CB 2 receptor British Journal of Pharmacology. 165: 2561-2574. PMID 21615724 DOI: 10.1111/J.1476-5381.2011.01503.X |
0.489 |
|
| 2012 |
Bátkai S, Mukhopadhyay P, Horváth B, Rajesh M, Gao RY, Mahadevan A, Amere M, Battista N, Lichtman AH, Gauson LA, Maccarrone M, Pertwee RG, Pacher P. Δ8-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors. British Journal of Pharmacology. 165: 2450-61. PMID 21470208 DOI: 10.1111/J.1476-5381.2011.01410.X |
0.453 |
|
| 2011 |
Brizzi A, Cascio MG, Frosini M, Ligresti A, Aiello F, Biotti I, Brizzi V, Pertwee RG, Corelli F, Marzo VD. Resorcinol-sn-glycerol derivatives: novel 2-arachidonoylglycerol mimetics endowed with high affinity and selectivity for cannabinoid type 1 receptor. Journal of Medicinal Chemistry. 54: 8278-8288. PMID 22044209 DOI: 10.1021/Jm200529H |
0.496 |
|
| 2011 |
Sagredo O, Pazos MR, Satta V, Ramos JA, Pertwee RG, Fernández-Ruiz J. Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease. Journal of Neuroscience Research. 89: 1509-18. PMID 21674569 DOI: 10.1002/Jnr.22682 |
0.392 |
|
| 2011 |
García C, Palomo-Garo C, García-Arencibia M, Ramos J, Pertwee R, Fernández-Ruiz J. Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease. British Journal of Pharmacology. 163: 1495-506. PMID 21323909 DOI: 10.1111/J.1476-5381.2011.01278.X |
0.466 |
|
| 2011 |
Rock EM, Goodwin JM, Limebeer CL, Breuer A, Pertwee RG, Mechoulam R, Parker LA. Interaction between non-psychotropic cannabinoids in marihuana: Effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews Psychopharmacology. 215: 505-512. PMID 21243485 DOI: 10.1007/S00213-010-2157-4 |
0.305 |
|
| 2011 |
Wiley JL, Breivogel CS, Mahadevan A, Pertwee RG, Cascio MG, Bolognini D, Huffman JW, Walentiny DM, Vann RE, Razdan RK, Martin BR. Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist. European Journal of Pharmacology. 651: 96-105. PMID 21114999 DOI: 10.1016/J.Ejphar.2010.10.085 |
0.467 |
|
| 2011 |
Cascio MG, Pertwee R. The function of the endocannabinoid system Marijuana and Madness: Second Edition. 23-34. DOI: 10.1017/CBO9780511706080.004 |
0.358 |
|
| 2010 |
Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, Mechoulam R, Ross RA. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CBâ‚ and CBâ‚‚. Pharmacological Reviews. 62: 588-631. PMID 21079038 DOI: 10.1124/Pr.110.003004 |
0.504 |
|
| 2010 |
Pasquini S, Ligresti A, Mugnaini C, Semeraro T, Cicione L, Rosa MD, Guida F, Luongo L, Chiaro MD, Cascio MG, Bolognini D, Marini P, Pertwee R, Maione S, Marzo VD, et al. Investigations on the 4-Quinolone-3-carboxylic Acid Motif. 3. Synthesis, Structure−Affinity Relationships, and Pharmacological Characterization of 6-Substituted 4-Quinolone-3-carboxamides as Highly Selective Cannabinoid-2 Receptor Ligands Journal of Medicinal Chemistry. 53: 5915-5928. PMID 20718492 DOI: 10.1021/Jm100123X |
0.458 |
|
| 2010 |
Brown I, Cascio MG, Wahle KW, Smoum R, Mechoulam R, Ross RA, Pertwee RG, Heys SD. Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis. 31: 1584-91. PMID 20660502 DOI: 10.1016/J.Ejso.2010.08.080 |
0.444 |
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| 2010 |
Jamontt JM, Molleman A, Pertwee RG, Parsons ME. The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis British Journal of Pharmacology. 160: 712-723. PMID 20590574 DOI: 10.1111/J.1476-5381.2010.00791.X |
0.358 |
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| 2010 |
Bolognini D, Costa B, Maione S, Comelli F, Marini P, Di Marzo V, Parolaro D, Ross RA, Gauson LA, Cascio MG, Pertwee RG. The plant cannabinoid Delta9-tetrahydrocannabivarin can decrease signs of inflammation and inflammatory pain in mice. British Journal of Pharmacology. 160: 677-87. PMID 20590571 DOI: 10.1111/J.1476-5381.2010.00756.X |
0.506 |
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| 2010 |
Thors L, Burston JJ, Alter BJ, McKinney MK, Cravatt BF, Ross RA, Pertwee RG, Gereau RW, Wiley JL, Fowler CJ. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. British Journal of Pharmacology. 160: 549-60. PMID 20590565 DOI: 10.1111/J.1476-5381.2010.00716.X |
0.503 |
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| 2010 |
Gertsch J, Pertwee RG, Di Marzo V. Phytocannabinoids beyond the Cannabis plant - do they exist? British Journal of Pharmacology. 160: 523-9. PMID 20590562 DOI: 10.1111/J.1476-5381.2010.00745.X |
0.378 |
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| 2010 |
Pertwee RG. Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists. Current Medicinal Chemistry. 17: 1360-81. PMID 20166927 DOI: 10.2174/092986710790980050 |
0.439 |
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| 2010 |
Robinson L, Goonawardena AV, Pertwee R, Hampson RE, Platt B, Riedel G. WIN55,212-2 induced deficits in spatial learning are mediated by cholinergic hypofunction. Behavioural Brain Research. 208: 584-92. PMID 20079375 DOI: 10.1016/J.Bbr.2010.01.004 |
0.346 |
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| 2010 |
Cascio MG, Gauson LA, Stevenson LA, Ross RA, Pertwee RG. Evidence that the plant cannabinoid cannabigerol is a highly potent alpha2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist. British Journal of Pharmacology. 159: 129-41. PMID 20002104 DOI: 10.1111/J.1476-5381.2009.00515.X |
0.534 |
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| 2010 |
Cascio MG, Bolognini D, Pertwee RG, Palazzo E, Corelli F, Pasquini S, Di Marzo V, Maione S. In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB2 receptor inverse agonists Pharmacological Research. 61: 349-354. PMID 19961936 DOI: 10.1016/J.Phrs.2009.11.011 |
0.533 |
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| 2010 |
Crocker PJ, Saha B, Ryan WJ, Wiley JL, Martin BR, Ross RA, Pertwee RG, Razdan RK. ChemInform Abstract: Development of Agonists, Partial Agonists, and Antagonists in the Δ8-Tetrahydrocannabinol Series. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200009178 |
0.328 |
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| 2010 |
Pertwee RG. ChemInform Abstract: Pharmacology of Cannabinoid Receptor Ligands Cheminform. 30: no-no. DOI: 10.1002/CHIN.199945328 |
0.365 |
|
| 2009 |
Riedel G, Fadda P, McKillop-Smith S, Pertwee RG, Platt B, Robinson L. Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice. British Journal of Pharmacology. 156: 1154-66. PMID 19378378 DOI: 10.1111/J.1476-5381.2008.00107.X |
0.399 |
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| 2009 |
Appendino G, Ligresti A, Minassi A, Cascio MG, Allarà M, Taglialatela-Scafati O, Pertwee RG, De Petrocellis L, Di Marzo V. Conformationally constrained fatty acid ethanolamides as cannabinoid and vanilloid receptor probes. Journal of Medicinal Chemistry. 52: 3001-9. PMID 19361197 DOI: 10.1021/Jm900130M |
0.473 |
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| 2009 |
Pertwee RG. Emerging strategies for exploiting cannabinoid receptor agonists as medicines. British Journal of Pharmacology. 156: 397-411. PMID 19226257 DOI: 10.1111/J.1476-5381.2008.00048.X |
0.487 |
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| 2009 |
Pertwee RG. GPR55: a new member of the cannabinoid receptor clan? British Journal of Pharmacology. 152: 984-986. PMID 17876300 DOI: 10.1038/Sj.Bjp.0707464 |
0.519 |
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| 2009 |
McPartland J, Glass M, Pertwee R. Meta-analysis of cannabinoid ligand binding affinity and receptor distribution: interspecies differences British Journal of Pharmacology. 152: 583-593. PMID 17641667 DOI: 10.1038/Sj.Bjp.0707399 |
0.369 |
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| 2008 |
Pertwee RG. Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. Addiction Biology. 13: 147-59. PMID 18482430 DOI: 10.1111/J.1369-1600.2008.00108.X |
0.543 |
|
| 2008 |
Robinson L, McKillop-Smith S, Ross NL, Pertwee RG, Hampson RE, Platt B, Riedel G. Hippocampal endocannabinoids inhibit spatial learning and limit spatial memory in rats. Psychopharmacology. 198: 551-63. PMID 18049812 DOI: 10.1007/S00213-007-1012-8 |
0.306 |
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| 2008 |
Croxford JL, Pryce G, Jackson SJ, Ledent C, Giovannoni G, Pertwee RG, Yamamura T, Baker D. Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis. Journal of Neuroimmunology. 193: 120-9. PMID 18037503 DOI: 10.1016/J.Jneuroim.2007.10.024 |
0.34 |
|
| 2008 |
McHugh D, Tanner C, Mechoulam R, Pertwee RG, Ross RA. Inhibition of human neutrophil chemotaxis by endogenous cannabinoids and phytocannabinoids: evidence for a site distinct from CB1 and CB2. Molecular Pharmacology. 73: 441-50. PMID 17965195 DOI: 10.1124/Mol.107.041863 |
0.46 |
|
| 2008 |
Pertwee RG. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin British Journal of Pharmacology. 153: 199-215. PMID 17828291 DOI: 10.1038/Sj.Bjp.0707442 |
0.54 |
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| 2008 |
Kumar RN, Chambers WA, Pertwee RG. Pharmacological actions and therapeutic uses of cannabis and cannabinoids: Cannabis and cannabinoids Anaesthesia. 56: 1059-1068. DOI: 10.1111/J.1365-2044.2001.02269.X |
0.321 |
|
| 2007 |
Pertwee RG. Cannabinoids and multiple sclerosis. Molecular Neurobiology. 36: 45-59. PMID 17952649 DOI: 10.1007/S12035-007-0005-2 |
0.388 |
|
| 2007 |
Xu H, Cheng CL, Chen M, Manivannan A, Cabay L, Pertwee RG, Coutts A, Forrester JV. Anti-inflammatory property of the cannabinoid receptor-2-selective agonist JWH-133 in a rodent model of autoimmune uveoretinitis. Journal of Leukocyte Biology. 82: 532-41. PMID 17537989 DOI: 10.1189/Jlb.0307159 |
0.431 |
|
| 2007 |
Ryan D, Drysdale AJ, Pertwee RG, Platt B. Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue. The European Journal of Neuroscience. 25: 2093-102. PMID 17419758 DOI: 10.1111/J.1460-9568.2007.05448.X |
0.359 |
|
| 2007 |
Maresz K, Pryce G, Ponomarev ED, Marsicano G, Croxford JL, Shriver LP, Ledent C, Cheng X, Carrier EJ, Mann MK, Giovannoni G, Pertwee RG, Yamamura T, Buckley NE, Hillard CJ, et al. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nature Medicine. 13: 492-7. PMID 17401376 DOI: 10.1038/Nm1561 |
0.408 |
|
| 2007 |
Pertwee RG, Thomas A, Stevenson LA, Ross RA, Varvel SA, Lichtman AH, Martin BR, Razdan RK. The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo. British Journal of Pharmacology. 150: 586-94. PMID 17245367 DOI: 10.1038/Sj.Bjp.0707124 |
0.352 |
|
| 2007 |
Thomas A, Baillie GL, Phillips AM, Razdan RK, Ross RA, Pertwee RG. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. British Journal of Pharmacology. 150: 613-23. PMID 17245363 DOI: 10.1038/Sj.Bjp.0707133 |
0.538 |
|
| 2007 |
Krylatov AV, Maslov LN, Ermakov SY, Lasukova OV, Barzakh EI, Crawford D, Pertwee RG. [Significance of cardiac cannabinoid receptors in regulation of cardiac rhythm, myocardial contractility, and electrophysiologic processes in heart]. Biology Bulletin. 34: 28-35. DOI: 10.1134/S1062359007010049 |
0.466 |
|
| 2006 |
Maslov LN, Lasukova OV, Krylatov AV, Hanus LO, Pertwee R, Ivanchuk II, Crowford D. Role of cannabinoid receptors in the regulation of cardiac contractility during ischemia/reperfusion Bulletin of Experimental Biology and Medicine. 142: 557-561. PMID 17415461 DOI: 10.1007/S10517-006-0417-4 |
0.415 |
|
| 2006 |
Cascio MG, Bisogno T, Palazzo E, Thomas AD, Stelt Mvd, Brizzi A, Novellis VD, Marabese I, Ross RA, Doelen Tvd, Brizzi V, Pertwee RG, Maione S, Marzo VD. In vitro and in vivo pharmacology of synthetic olivetol‐ or resorcinol‐derived cannabinoid receptor ligands British Journal of Pharmacology. 149: 431-440. PMID 16953186 DOI: 10.1038/Sj.Bjp.0706888 |
0.478 |
|
| 2006 |
Pertwee RG. The pharmacology of cannabinoid receptors and their ligands: an overview. International Journal of Obesity. 30. PMID 16570099 DOI: 10.1038/Sj.Ijo.0803272 |
0.534 |
|
| 2006 |
Thomas A, Pertwee RG. The bioassay of cannabinoids using the mouse isolated vas deferens. Methods in Molecular Medicine. 123: 191-207. PMID 16506409 DOI: 10.1385/1-59259-999-0:191 |
0.527 |
|
| 2006 |
Appendino G, Cascio MG, Bacchiega S, Moriello AS, Minassi A, Thomas A, Ross R, Pertwee R, Petrocellis LD, Marzo VD. First "hybrid" ligands of vanilloid TRPV1 and cannabinoid CB2 receptors and non-polyunsaturated fatty acid-derived CB2-selective ligands. Febs Letters. 580: 568-574. PMID 16406364 DOI: 10.1016/J.Febslet.2005.12.069 |
0.534 |
|
| 2006 |
Fadda P, Robinson L, Fratta W, Pertwee RG, Riedel G. Scopolamine and MK801-induced working memory deficits in rats are not reversed by CBD-rich cannabis extracts. Behavioural Brain Research. 168: 307-11. PMID 16406104 DOI: 10.1016/J.Bbr.2005.11.022 |
0.309 |
|
| 2006 |
Pertwee RG. Cannabinoid pharmacology: the first 66 years. British Journal of Pharmacology. 147: S163-71. PMID 16402100 DOI: 10.1038/Sj.Bjp.0706406 |
0.459 |
|
| 2006 |
Drysdale AJ, Ryan D, Pertwee RG, Platt B. Cannabidiol-induced intracellular Ca2+ elevations in hippocampal cells. Neuropharmacology. 50: 621-31. PMID 16386766 DOI: 10.1016/J.Neuropharm.2005.11.008 |
0.306 |
|
| 2006 |
McHugh D, McMaster RS, Pertwee RG, Roy S, Mahadevan A, Razdan RK, Ross RA. Novel compounds that interact with both leukotriene B4 receptors and vanilloid TRPV1 receptors. The Journal of Pharmacology and Experimental Therapeutics. 316: 955-65. PMID 16207832 DOI: 10.1124/Jpet.105.095992 |
0.487 |
|
| 2005 |
Pertwee RG. Pharmacological actions of cannabinoids. Handbook of Experimental Pharmacology. 168: 1-51. PMID 16596770 DOI: 10.1007/3-540-26573-2_1 |
0.467 |
|
| 2005 |
Pertwee RG. The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. The Aaps Journal. 7: E625-54. PMID 16353941 DOI: 10.1208/Aapsj070364 |
0.536 |
|
| 2005 |
Krylatov AV, Maslov LN, Lasukova OV, Pertwee RG. Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart. Bulletin of Experimental Biology and Medicine. 139: 558-561. PMID 16224548 DOI: 10.1007/S10517-005-0344-9 |
0.473 |
|
| 2005 |
Thomas A, Stevenson LA, Wease KN, Price MR, Baillie G, Ross RA, Pertwee RG. Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist. British Journal of Pharmacology. 146: 917-26. PMID 16205722 DOI: 10.1038/Sj.Bjp.0706414 |
0.439 |
|
| 2005 |
Price MR, Baillie GL, Thomas A, Stevenson LA, Easson M, Goodwin R, McLean A, McIntosh L, Goodwin G, Walker G, Westwood P, Marrs J, Thomson F, Cowley P, Christopoulos A, ... Pertwee RG, et al. Allosteric modulation of the cannabinoid CB1 receptor. Molecular Pharmacology. 68: 1484-95. PMID 16113085 DOI: 10.1124/Mol.105.016162 |
0.445 |
|
| 2005 |
Thomas BF, Francisco ME, Seltzman HH, Thomas JB, Fix SE, Schulz AK, Gilliam AF, Pertwee RG, Stevenson LA. Synthesis of long-chain amide analogs of the cannabinoid CB1 receptor antagonist N-(piperidinyl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716) with unique binding selectivities and pharmacological activities. Bioorganic & Medicinal Chemistry. 13: 5463-74. PMID 15994087 DOI: 10.1016/J.Bmc.2005.06.005 |
0.401 |
|
| 2005 |
Pertwee RG, Thomas A, Stevenson LA, Maor Y, Mechoulam R. Evidence that (-)-7-hydroxy-4'-dimethylheptyl-cannabidiol activates a non-CB(1), non-CB(2), non-TRPV1 target in the mouse vas deferens. Neuropharmacology. 48: 1139-46. PMID 15910889 DOI: 10.1016/J.Neuropharm.2005.01.010 |
0.487 |
|
| 2005 |
Pertwee RG. Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sciences. 76: 1307-24. PMID 15670612 DOI: 10.1016/J.Lfs.2004.10.025 |
0.532 |
|
| 2004 |
Maslov LN, Lasukova OV, Krylatov AV, Uzhachenko RV, Pertwee R. Selective cannabinoid receptor agonist HU-210 decreases pump function of isolated perfused heart: role of cAMP and cGMP. Bulletin of Experimental Biology and Medicine. 138: 550-553. PMID 16134810 DOI: 10.1007/S10517-005-0123-7 |
0.408 |
|
| 2004 |
Ghafouri N, Tiger G, Razdan RK, Mahadevan A, Pertwee RG, Martin BR, Fowler CJ. Inhibition of monoacylglycerol lipase and fatty acid amide hydrolase by analogues of 2-arachidonoylglycerol. British Journal of Pharmacology. 143: 774-84. PMID 15492019 DOI: 10.1038/Sj.Bjp.0705948 |
0.328 |
|
| 2004 |
Thomas A, Ross RA, Saha B, Mahadevan A, Razdan RK, Pertwee RG. 6"-Azidohex-2"-yne-cannabidiol: a potential neutral, competitive cannabinoid CB1 receptor antagonist. European Journal of Pharmacology. 487: 213-21. PMID 15033394 DOI: 10.1016/J.Ejphar.2004.01.023 |
0.535 |
|
| 2004 |
Pertwee RG. Pharmacological and therapeutic targets for Δ9 tetrahydrocannabinol and cannabidiol Euphytica. 140: 73-82. DOI: 10.1007/S10681-004-4756-9 |
0.484 |
|
| 2003 |
Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 46: 3221-9. PMID 12852753 DOI: 10.1021/Jm020558C |
0.379 |
|
| 2003 |
Pertwee RG. Inverse agonism at cannabinoid receptors International Congress Series. 1249: 75-86. DOI: 10.1016/S0531-5131(03)00612-5 |
0.407 |
|
| 2002 |
Pertwee RG, Ross RA, Craib SJ, Thomas A. (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. European Journal of Pharmacology. 456: 99-106. PMID 12450575 DOI: 10.1016/S0014-2999(02)02624-9 |
0.487 |
|
| 2002 |
Ugdyzhekova DS, Krylatov AV, Bernatskaya NA, Maslov LN, Mechoulam R, Pertwee RG. Activation of cannabinoid receptors decreases the area of ischemic myocardial necrosis Bulletin of Experimental Biology and Medicine. 133: 125-126. PMID 12428278 DOI: 10.1023/A:1015526217332 |
0.444 |
|
| 2002 |
Krylatov AV, Uzhachenko RV, Maslov LN, Bernatskaya NA, Makriyannis A, Mechoulam R, Pertwee RG, Sal'nikova OM, Stefano JB, Lishmanov YB. Endogenous cannabinoids improve myocardial resistance to arrhythmogenic effects of coronary occlusion and reperfusion: A possible mechanism Bulletin of Experimental Biology and Medicine. 133: 122-124. PMID 12428277 DOI: 10.1023/A:1015574100494 |
0.309 |
|
| 2002 |
Pertwee RG. Cannabinoids and multiple sclerosis. Pharmacology & Therapeutics. 95: 165-74. PMID 12182963 DOI: 10.1016/S0163-7258(02)00255-3 |
0.309 |
|
| 2002 |
Davies SN, Pertwee RG, Riedel G. Functions of cannabinoid receptors in the hippocampus. Neuropharmacology. 42: 993-1007. PMID 12128000 DOI: 10.1016/S0028-3908(02)00060-6 |
0.447 |
|
| 2002 |
Coutts AA, Irving AJ, Mackie K, Pertwee RG, Anavi-Goffer S. Localisation of cannabinoid CB(1) receptor immunoreactivity in the guinea pig and rat myenteric plexus. The Journal of Comparative Neurology. 448: 410-22. PMID 12115703 DOI: 10.1002/Cne.10270 |
0.491 |
|
| 2002 |
Francisco ME, Seltzman HH, Gilliam AF, Mitchell RA, Rider SL, Pertwee RG, Stevenson LA, Thomas BF. Synthesis and structure-activity relationships of amide and hydrazide analogues of the cannabinoid CB(1) receptor antagonist N-(piperidinyl)- 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716). Journal of Medicinal Chemistry. 45: 2708-19. PMID 12061874 DOI: 10.1021/Jm010498V |
0.442 |
|
| 2002 |
Pertwee RG, Ross RA. Cannabinoid receptors and their ligands. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 66: 101-21. PMID 12052030 DOI: 10.1054/Plef.2001.0341 |
0.529 |
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| 2002 |
Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews. 54: 161-202. PMID 12037135 DOI: 10.1124/Pr.54.2.161 |
0.522 |
|
| 2002 |
Ross RA, Craib SJ, Stevenson LA, Pertwee RG, Henderson A, Toole J, Ellington HC. Pharmacological characterization of the anandamide cyclooxygenase metabolite: prostaglandin E2 ethanolamide. The Journal of Pharmacology and Experimental Therapeutics. 301: 900-7. PMID 12023517 DOI: 10.1124/Jpet.301.3.900 |
0.327 |
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| 2002 |
Lan R, Gatley J, Lu Q, Fan P, Fernando SR, Volkow ND, Pertwee R, Makriyannis A. Design and synthesis of the CB1 selective cannabinoid antagonist AM281: a potential human SPECT ligand. Aaps Pharmsci. 1: E4. PMID 11741201 DOI: 10.1208/Ps010204 |
0.482 |
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| 2002 |
Pertwee R. Cannabinoid receptors and their ligands European Neuropsychopharmacology. 12: 127-128. DOI: 10.1016/S0924-977X(02)80067-0 |
0.457 |
|
| 2002 |
Pertwee RG. New developments in the pharmacology of cannabinoids Pharmacochemistry Library. 32: 249-258. DOI: 10.1016/S0165-7208(02)80025-3 |
0.476 |
|
| 2001 |
Al-Hayani A, Wease KN, Ross RA, Pertwee RG, Davies SN. The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice. Neuropharmacology. 41: 1000-5. PMID 11747904 DOI: 10.1016/S0028-3908(01)00145-9 |
0.481 |
|
| 2001 |
Kumar RN, Chambers WA, Pertwee RG. Pharmacological actions and therapeutic uses of cannabis and cannabinoids. Anaesthesia. 56: 1059-1068. PMID 11703238 DOI: 10.1046/J.1365-2044.2001.02269.X |
0.332 |
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| 2001 |
Krylatov AV, Ugdyzhekova DS, Bernatskaya NA, Maslov LN, Mekhoulam R, Pertwee RG, Stephano GB. Activation of type II cannabinoid receptors improves myocardial tolerance to arrhythmogenic effects of coronary occlusion and reperfusion. Bulletin of Experimental Biology and Medicine. 131: 523-525. PMID 11586395 DOI: 10.1023/A:1012381914518 |
0.444 |
|
| 2001 |
Craib SJ, Ellington HC, Pertwee RG, Ross RA. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus. British Journal of Pharmacology. 134: 30-7. PMID 11522594 DOI: 10.1038/Sj.Bjp.0704223 |
0.425 |
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| 2001 |
Pertwee RG. Cannabinoids and the gastrointestinal tract Gut. 48: 859-867. PMID 11358910 DOI: 10.1136/Gut.48.6.859 |
0.502 |
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| 2001 |
Pertwee RG. Cannabinoid receptors and pain. Progress in Neurobiology. 63: 569-611. PMID 11164622 DOI: 10.1016/S0301-0082(00)00031-9 |
0.504 |
|
| 2001 |
Ross RA, Gibson TM, Brockie HC, Leslie M, Pashmi G, Craib SJ, Di Marzo V, Pertwee RG. Structure-activity relationship for the endogenous cannabinoid, anandamide, and certain of its analogues at vanilloid receptors in transfected cells and vas deferens. British Journal of Pharmacology. 132: 631-40. PMID 11159715 DOI: 10.1038/Sj.Bjp.0703850 |
0.456 |
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| 2001 |
Gauldie SD, McQueen DS, Pertwee R, Chessell IP. Anandamide activates peripheral nociceptors in normal and arthritic rat knee joints. British Journal of Pharmacology. 132: 617-21. PMID 11159713 DOI: 10.1038/Sj.Bjp.0703890 |
0.325 |
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| 2001 |
Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Makriyannis A, Khanolkar A, Layward L, Fezza F, Bisogno T, Di Marzo V. Endocannabinoids control spasticity in a multiple sclerosis model The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 300-302. PMID 11156943 DOI: 10.1096/Fj.00-0399Fje |
0.364 |
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| 2001 |
Ross RA, Coutts AA, McFarlane SM, Anavi-Goffer S, Irving AJ, Pertwee RG, MacEwan DJ, Scott RH. Actions of cannabinoid receptor ligands on rat cultured sensory neurones: implications for antinociception. Neuropharmacology. 40: 221-32. PMID 11114401 DOI: 10.1016/S0028-3908(00)00135-0 |
0.439 |
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| 2001 |
Coutts AA, Anavi-Goffer S, Ross RA, MacEwan DJ, Mackie K, Pertwee RG, Irving AJ. Agonist-induced internalization and trafficking of cannabinoid CB1 receptors in hippocampal neurons. The Journal of Neuroscience. 21: 2425-2433. DOI: 10.1523/Jneurosci.21-07-02425.2001 |
0.501 |
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| 2000 |
Pertwee RG. Neuropharmacology and therapeutic potential of cannabinoids. Addiction Biology. 5: 37-46. PMID 20575818 DOI: 10.1080/13556210071252 |
0.49 |
|
| 2000 |
Pertwee RG. Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development Expert Opinion On Investigational Drugs. 9: 1553-1571. PMID 11060760 DOI: 10.1517/13543784.9.7.1553 |
0.524 |
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| 2000 |
Petrocellis LD, Bisogno T, Davis JB, Pertwee RG, Marzo VD. Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin‐like activity Febs Letters. 483: 52-56. PMID 11033355 DOI: 10.1016/S0014-5793(00)02082-2 |
0.479 |
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| 2000 |
Ross RA, Brockie HC, Pertwee RG. Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide. European Journal of Pharmacology. 401: 121-30. PMID 10924916 DOI: 10.1016/S0014-2999(00)00437-4 |
0.37 |
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| 2000 |
Irving AJ, Coutts AA, Harvey J, Rae MG, Mackie K, Bewick GS, Pertwee RG. Functional expression of cell surface cannabinoid CB(1) receptors on presynaptic inhibitory terminals in cultured rat hippocampal neurons. Neuroscience. 98: 253-62. PMID 10854756 DOI: 10.1016/S0306-4522(00)00120-2 |
0.45 |
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| 2000 |
Pertwee RG, Gibson TM, Stevenson LA, Ross RA, Banner WK, Saha B, Razdan RK, Martin BR. O-1057, a potent water-soluble cannabinoid receptor agonist with antinociceptive properties. British Journal of Pharmacology. 129: 1577-84. PMID 10780961 DOI: 10.1038/Sj.Bjp.0703245 |
0.414 |
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| 2000 |
Baker D, Pryce G, Croxford JL, Brown P, Pertwee RG, Huffman JW, Layward L. Cannabinoids control spasticity and tremor in a multiple sclerosis model. Nature. 404: 84-7. PMID 10716447 DOI: 10.1038/35003583 |
0.388 |
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| 2000 |
Coutts AA, Brewster N, Ingram T, Razdan RK, Pertwee RG. Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine. British Journal of Pharmacology. 129: 645-52. PMID 10683188 DOI: 10.1038/Sj.Bjp.0703094 |
0.372 |
|
| 2000 |
Pertwee RG. Receptors and ligands European Neuropsychopharmacology. 10: 181-182. DOI: 10.1016/S0924-977X(00)80090-5 |
0.449 |
|
| 1999 |
Hanus L, Breuer A, Tchilibon S, Shiloah S, Goldenberg D, Horowitz M, Pertwee RG, Ross RA, Mechoulam R, Fride E. HU-308: a specific agonist for CB(2), a peripheral cannabinoid receptor. Proceedings of the National Academy of Sciences of the United States of America. 96: 14228-33. PMID 10588688 DOI: 10.1073/Pnas.96.25.14228 |
0.475 |
|
| 1999 |
Pertwee RG. Cannabis and cannabinoids: pharmacology and rationale for clinical use. Forschende Komplementarmedizin. 6: 12-15. PMID 10575283 DOI: 10.1159/000057150 |
0.495 |
|
| 1999 |
Ross RA, Gibson TM, Stevenson LA, Saha B, Crocker P, Razdan RK, Pertwee RG. Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-delta8-tetrahydrocannabinol at cannabinoid receptors. British Journal of Pharmacology. 128: 735-43. PMID 10516656 DOI: 10.1038/Sj.Bjp.0702836 |
0.339 |
|
| 1999 |
Pertwee RG. Evidence for the presence of CB1 cannabinoid receptors on peripheral neurones and for the existence of neuronal non-CB1 cannabinoid receptors Life Sciences. 65: 597-605. PMID 10462060 DOI: 10.1016/S0024-3205(99)00282-9 |
0.482 |
|
| 1999 |
Ross RA, Brockie HC, Stevenson LA, Murphy VL, Templeton F, Makriyannis A, Pertwee RG. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. British Journal of Pharmacology. 126: 665-72. PMID 10188977 DOI: 10.1038/Sj.Bjp.0702351 |
0.448 |
|
| 1999 |
Lan R, Liu Q, Fan P, Lin S, Fernando SR, McCallion D, Pertwee R, Makriyannis A. Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. Journal of Medicinal Chemistry. 42: 769-76. PMID 10052983 DOI: 10.1021/Jm980363Y |
0.458 |
|
| 1999 |
Pertwee RG. Prescribing cannabinoids for multiple sclerosis - Current issues Cns Drugs. 11: 327-334. DOI: 10.2165/00023210-199911050-00001 |
0.302 |
|
| 1999 |
Crocker PJ, Saha B, Ryan WJ, Wiley JL, Martin BR, Ross RA, Pertwee RG, Razdan RK. Development of agonists, partial agonists and antagonists in the Δ8-Tetrahydrocannabinol series Tetrahedron. 55: 13907-13926. DOI: 10.1016/S0040-4020(99)00849-2 |
0.405 |
|
| 1998 |
Ross RA, Brockie HC, Fernando SR, Saha B, Razdan RK, Pertwee RG. Comparison of cannabinoid binding sites in guinea‐pig forebrain and small intestine British Journal of Pharmacology. 125: 1345-1351. PMID 9863666 DOI: 10.1038/Sj.Bjp.0702204 |
0.427 |
|
| 1998 |
Reggio PH, Basu-Dutt S, Barnett-Norris J, Castro MT, Hurst DP, Seltzman HH, Roche MJ, Gilliam AF, Thomas BF, Stevenson LA, Pertwee RG, Abood ME. The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes. Journal of Medicinal Chemistry. 41: 5177-87. PMID 9857088 DOI: 10.1021/Jm9801197 |
0.32 |
|
| 1998 |
Paton GS, Pertwee RG, Davies SN. Correlation between cannabinoid mediated effects on paired pulse depression and induction of long term potentiation in the rat hippocampal slice Neuropharmacology. 37: 1123-1130. PMID 9833642 DOI: 10.1016/S0028-3908(98)00096-3 |
0.396 |
|
| 1998 |
Marzo VD, Bisogno T, Melck D, Ross R, Brockie H, Stevenson L, Pertwee R, Petrocellis LD. Interactions between synthetic vanilloids and the endogenous cannabinoid system Febs Letters. 436: 449-454. PMID 9801167 DOI: 10.1016/S0014-5793(98)01175-2 |
0.445 |
|
| 1998 |
Pertwee RG. Pharmacological, physiological and clinical implications of the discovery of cannabinoid receptors Biochemical Society Transactions. 26: 267-272. PMID 9649760 DOI: 10.1042/Bst0260267 |
0.501 |
|
| 1998 |
Coutts AA, Pertwee RG. Evidence that cannabinoid-induced inhibition of electrically evoked contractions of the myenteric plexus - longitudinal muscle preparation of guinea-pig small intestine can be modulated by Ca2+ and cAMP Canadian Journal of Physiology and Pharmacology. 76: 340-346. DOI: 10.1139/Y98-021 |
0.344 |
|
| 1997 |
Griffin G, Fernando SR, Ross RA, McKay NG, Ashford ML, Shire D, Huffman JW, Yu S, Lainton JA, Pertwee RG. Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals. European Journal of Pharmacology. 339: 53-61. PMID 9450616 DOI: 10.1016/S0014-2999(97)01336-8 |
0.528 |
|
| 1997 |
Coull MA, Johnston AT, Pertwee RG, Davies SN. Action of δ-9-tetrahydrocannabinol on gabaa receptor-mediated responses in a grease-gap recording preparation of the rat hippocampal slice Neuropharmacology. 36: 1387-1392. PMID 9423926 DOI: 10.1016/S0028-3908(97)00110-X |
0.346 |
|
| 1997 |
Reggio PH, Wang T, Brown AE, Fleming DN, Seltzman HH, Griffin G, Pertwee RG, Compton DR, Abood ME, Martin BR. Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: synthesis and characterization of a series of O,2-propano-delta 8-tetrahydrocannabinol analogs. Journal of Medicinal Chemistry. 40: 3312-8. PMID 9379452 DOI: 10.1021/Jm970136G |
0.403 |
|
| 1997 |
Seltzman HH, Fleming DN, Thomas BF, Gilliam AF, McCallion DS, Pertwee RG, Compton DR, Martin BR. Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide. Journal of Medicinal Chemistry. 40: 3626-34. PMID 9357529 DOI: 10.1021/Jm9702950 |
0.435 |
|
| 1997 |
Pertwee RG. Pharmacology Of Cannabinoid Cb1 And Cb2 Receptors Pharmacology & Therapeutics. 74: 129-180. PMID 9336020 DOI: 10.1016/S0163-7258(97)82001-3 |
0.529 |
|
| 1997 |
López-Redondo F, Lees GM, Pertwee RG. Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum. British Journal of Pharmacology. 122: 330-4. PMID 9313943 DOI: 10.1038/Sj.Bjp.0701393 |
0.711 |
|
| 1997 |
Fernando SR, Pertwee RG. Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist British Journal of Pharmacology. 121: 1716-1720. PMID 9283708 DOI: 10.1038/Sj.Bjp.0701303 |
0.38 |
|
| 1997 |
Coutts AA, Pertwee RG. Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea‐pig myenteric plexus British Journal of Pharmacology. 121: 1557-1566. PMID 9283688 DOI: 10.1038/Sj.Bjp.0701301 |
0.416 |
|
| 1997 |
Pertwee RG. Cannabis and Cannabinoids: Pharmacology and Rationale for Clinical Use Pharmacy and Pharmacology Communications. 3: 539-545. DOI: 10.1111/J.2042-7158.1997.Tb00491.X |
0.501 |
|
| 1996 |
Pertwee RG, Fernando SR, Griffin G, Ryan W, Razdan RK, Compton DR, Martin BR. Agonist-antagonist characterization of 6'-cyanohex-2'-yne-delta 8-tetrahydrocannabinol in two isolated tissue preparations. European Journal of Pharmacology. 315: 195-201. PMID 8960884 DOI: 10.1016/S0014-2999(96)00631-0 |
0.417 |
|
| 1996 |
Pertwee RG, Fernando SR, Nash JE, Coutts AA. Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine British Journal of Pharmacology. 118: 2199-2205. PMID 8864562 DOI: 10.1111/J.1476-5381.1996.Tb15663.X |
0.43 |
|
| 1996 |
Pertwee RG, Fernando SR. Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder. British Journal of Pharmacology. 118: 2053-2058. PMID 8864542 DOI: 10.1111/J.1476-5381.1996.Tb15643.X |
0.445 |
|
| 1996 |
Pertwee RG, Joe-Adigwe G, Hawksworth GM. Further evidence for the presence of cannabinoid CB1 receptors in mouse vas deferens European Journal of Pharmacology. 296: 169-172. PMID 8838453 DOI: 10.1016/0014-2999(95)00790-3 |
0.468 |
|
| 1996 |
Pertwee RG. Editorial: Central & Peripheral Nervous Systems: Cannabinoid receptor ligands: clinical and neuropharmacological considerations relevant to future drug discovery and development Expert Opinion On Investigational Drugs. 5: 1245-1253. DOI: 10.1517/13543784.5.10.1245 |
0.528 |
|
| 1995 |
Pertwee RG, Griffin G, Lainton JAH, Huffman JW. Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens European Journal of Pharmacology. 284: 241-247. PMID 8666005 DOI: 10.1016/0014-2999(95)00318-F |
0.476 |
|
| 1995 |
Reggio PH, Bramblett RD, Yuknavich H, Seltzman HH, Fleming DN, Fernando SR, Stevenson LA, Pertwee RG. The design, synthesis and testing of desoxy-CBD: further evidence for a region of steric interference at the cannabinoid receptor. Life Sciences. 56: 2025-2032. PMID 7776828 DOI: 10.1016/0024-3205(95)00185-9 |
0.502 |
|
| 1995 |
Pertwee R, Griffin G, Fernando S, Li X, Hill A, Makriyannis A. AM630, a competitive cannabinoid receptor antagonist. Life Sciences. 56: 1949-55. PMID 7776818 DOI: 10.1016/0024-3205(95)00175-6 |
0.509 |
|
| 1995 |
Pertwee RG, Fernando SR, Griffin G, Abadji V, Makriyannis A. Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations European Journal of Pharmacology. 272: 73-78. PMID 7713152 DOI: 10.1016/0014-2999(94)00618-H |
0.383 |
|
| 1995 |
Pertwee RG, Griffin G. A preliminary investigation of the mechanisms underlying cannabinoid tolerance in the mouse vas deferens European Journal of Pharmacology. 272: 67-72. PMID 7713151 DOI: 10.1016/0014-2999(94)00617-G |
0.406 |
|
| 1995 |
Wickens AP, Pertwee RG. Effect of delta 9-tetrahydrocannabinol on circling in rats induced by intranigral muscimol administration. European Journal of Pharmacology. 282: 251-4. PMID 7498284 DOI: 10.1016/0014-2999(95)00346-M |
0.318 |
|
| 1994 |
Abadji V, Lin S, Taha G, Griffin G, Stevenson LA, Pertwee RG, Makriyannis A. (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. Journal of Medicinal Chemistry. 37: 1889-93. PMID 8021930 DOI: 10.1021/Jm00038A020 |
0.403 |
|
| 1994 |
Collins DR, Pertwee RG, Davies SN. The action of synthetic cannabinoids on the induction of long-term potentiation in the rat hippocampal slice. European Journal of Pharmacology. 259: R7-8. PMID 7982446 DOI: 10.1016/0014-2999(94)90666-1 |
0.342 |
|
| 1994 |
Pertwee R, Griffin G, Hanusˇ L, Mechoulam R. Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia European Journal of Pharmacology. 259: 115-120. PMID 7957604 DOI: 10.1016/0014-2999(94)90499-5 |
0.325 |
|
| 1994 |
Martin BR, Childers S, Howlett A, Mechoulam R, Pertwee R. Cannabinoid receptors: Pharmacology, second messenger systems and endogenous ligands Nida Research Monograph Series. 55-60. |
0.337 |
|
| 1993 |
Pertwee RG, Stevenson LA, Griffin G. Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide British Journal of Pharmacology. 110: 1483-1490. PMID 8306090 DOI: 10.1111/J.1476-5381.1993.Tb13989.X |
0.356 |
|
| 1993 |
Pertwee R. The evidence for the existence of cannabinoid receptors. General Pharmacology-the Vascular System. 24: 811-824. PMID 8224735 DOI: 10.1016/0306-3623(93)90154-P |
0.49 |
|
| 1993 |
Wickens AP, Pertwee RG. delta 9-Tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats. European Journal of Pharmacology. 250: 205-8. PMID 8119321 DOI: 10.1016/0014-2999(93)90646-Y |
0.412 |
|
| 1992 |
Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R. Isolation And Structure Of A Brain Constituent That Binds To The Cannabinoid Receptor Science. 258: 1946-1949. PMID 1470919 DOI: 10.1126/Science.1470919 |
0.451 |
|
| 1992 |
Pertwee RG, Stevenson LA, Elrick DB, Mechoulam R, Corbett AD. Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas-deferens and the myenteric plexus preparation of guinea-pig small-intestine British Journal of Pharmacology. 105: 980-984. PMID 1324060 DOI: 10.1111/J.1476-5381.1992.Tb09088.X |
0.386 |
|
| 1991 |
Pertwee RG, Browne SE, Ross TM, Stretton CD. An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol. Pharmacology, Biochemistry, and Behavior. 40: 581-5. PMID 1666920 DOI: 10.1016/0091-3057(91)90366-A |
0.346 |
|
| 1991 |
Pertwee RG, Wickens AP. Enhancement by chlordiazepoxide of catalepsy induced in rats by intravenous or intrapallidal injections of enantiomeric cannabinoids. Neuropharmacology. 30: 237-44. PMID 1649415 DOI: 10.1016/0028-3908(91)90150-A |
0.33 |
|
| 1988 |
Pertwee RG. The central neuropharmacology of psychotropic cannabinoids. Pharmacology & Therapeutics. 36: 189-261. PMID 3279430 DOI: 10.1016/0163-7258(88)90106-4 |
0.301 |
|
| 1988 |
Pertwee RG, Hedley D, McQueen ASM, Gentleman SM. The hypothermic response of mice to delta-9-tetrahydrocannabinol is enhanced by chlorpromazine, thioxanthenes, alpha-adrenoceptor antagonists and pentolinium but not by SCH 23390 or sulpiride. Neuropharmacology. 27: 149-155. PMID 2895430 DOI: 10.1016/0028-3908(88)90164-5 |
0.313 |
|
| 1977 |
Pertwee RG. Pharmacology of Marihuana Neuroscience. 2: 181. DOI: 10.1016/0306-4522(77)90080-X |
0.361 |
|
| 1974 |
Lawrence DK, Pertwee RG, Gill EW, Piper JM. Brain levels and relative potency of the 1,2-dimethylheptyl analogue of delta1-tetrahydrocannabinol in mice. Biochemical Pharmacology. 23: 3017-27. PMID 4429599 DOI: 10.1016/0006-2952(74)90277-9 |
0.322 |
|
| 1972 |
Jones G, Pertwee RG. A metabolic interaction in vivo between cannabidiol and Δ1‐tetrahydrocannabinol British Journal of Pharmacology. 45: 375-377. PMID 5048656 DOI: 10.1111/J.1476-5381.1972.Tb08092.X |
0.305 |
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