| Year |
Citation |
Score |
| 2018 |
Clancy JP, Cotton CU, Donaldson SH, Solomon GM, VanDevanter DR, Boyle MP, Gentzsch M, Nick JA, Illek B, Wallenburg JC, Sorscher EJ, Amaral MD, Beekman JM, Naren AP, Bridges RJ, ... ... Skach W, et al. CFTR modulator theratyping: Current status, gaps and future directions. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 29934203 DOI: 10.1016/J.Jcf.2018.05.004 |
0.312 |
|
| 2015 |
Patterson MA, Bandyopadhyay A, Devaraneni PK, Woodward J, Rooney L, Yang Z, Skach WR. The Ribosome-Sec61 Translocon Complex Forms a Cytosolically Restricted Environment for Early Polytopic Membrane Protein Folding. The Journal of Biological Chemistry. PMID 26254469 DOI: 10.1074/jbc.M115.672261 |
0.42 |
|
| 2015 |
Conti BJ, Devaraneni PK, Yang Z, David LL, Skach WR. Cotranslational stabilization of Sec62/63 within the ER Sec61 translocon is controlled by distinct substrate-driven translocation events. Molecular Cell. 58: 269-83. PMID 25801167 DOI: 10.1016/J.Molcel.2015.02.018 |
0.333 |
|
| 2014 |
Conti BJ, Elferich J, Yang Z, Shinde U, Skach WR. Cotranslational folding inhibits translocation from within the ribosome-Sec61 translocon complex. Nature Structural & Molecular Biology. 21: 228-35. PMID 24561504 DOI: 10.1038/Nsmb.2779 |
0.373 |
|
| 2012 |
Liu X, O'Donnell N, Landstrom A, Skach WR, Dawson DC. Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activity. Biochemistry. 51: 5113-24. PMID 22680785 DOI: 10.1021/Bi300018E |
0.357 |
|
| 2011 |
Richards R, Scholz I, Powers C, Skach WR, Früh K. The cytoplasmic domain of rhesus cytomegalovirus Rh178 interrupts translation of major histocompatibility class I leader peptide-containing proteins prior to translocation. Journal of Virology. 85: 8766-76. PMID 21715474 DOI: 10.1128/JVI.05021-11 |
0.333 |
|
| 2011 |
Matsumura Y, Rooney L, Skach WR. In vitro methods for CFTR biogenesis. Methods in Molecular Biology (Clifton, N.J.). 741: 233-53. PMID 21594789 DOI: 10.1007/978-1-61779-117-8_16 |
0.308 |
|
| 2009 |
Skach WR. Cellular mechanisms of membrane protein folding. Nature Structural & Molecular Biology. 16: 606-12. PMID 19491932 DOI: 10.1038/nsmb.1600 |
0.382 |
|
| 2009 |
Pitonzo D, Yang Z, Matsumura Y, Johnson AE, Skach WR. Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon. Molecular Biology of the Cell. 20: 685-98. PMID 19019984 DOI: 10.1091/Mbc.E08-09-0902 |
0.411 |
|
| 2008 |
Daniel CJ, Conti B, Johnson AE, Skach WR. Control of translocation through the Sec61 translocon by nascent polypeptide structure within the ribosome. The Journal of Biological Chemistry. 283: 20864-73. PMID 18480044 DOI: 10.1074/Jbc.M803517200 |
0.387 |
|
| 2007 |
Skach WR. The expanding role of the ER translocon in membrane protein folding. The Journal of Cell Biology. 179: 1333-5. PMID 18166647 DOI: 10.1083/jcb.200711107 |
0.404 |
|
| 2007 |
Buck TM, Wagner J, Grund S, Skach WR. A novel tripartite motif involved in aquaporin topogenesis, monomer folding and tetramerization. Nature Structural & Molecular Biology. 14: 762-9. PMID 17632520 DOI: 10.1038/nsmb1275 |
0.342 |
|
| 2006 |
Skach WR. CFTR: new members join the fold. Cell. 127: 673-5. PMID 17110327 DOI: 10.1016/j.cell.2006.11.002 |
0.302 |
|
| 2006 |
Pitonzo D, Skach WR. Molecular mechanisms of aquaporin biogenesis by the endoplasmic reticulum Sec61 translocon. Biochimica Et Biophysica Acta. 1758: 976-88. PMID 16782047 DOI: 10.1016/j.bbamem.2006.04.021 |
0.328 |
|
| 2005 |
Sadlish H, Pitonzo D, Johnson AE, Skach WR. Sequential triage of transmembrane segments by Sec61alpha during biogenesis of a native multispanning membrane protein. Nature Structural & Molecular Biology. 12: 870-8. PMID 16186821 DOI: 10.1038/Nsmb994 |
0.38 |
|
| 2005 |
Oberdorf J, Pitonzo D, Skach WR. An energy-dependent maturation step is required for release of the cystic fibrosis transmembrane conductance regulator from early endoplasmic reticulum biosynthetic machinery. The Journal of Biological Chemistry. 280: 38193-202. PMID 16166089 DOI: 10.1074/jbc.M504200200 |
0.337 |
|
| 2005 |
Carlson E, Bays N, David L, Skach WR. Reticulocyte lysate as a model system to study endoplasmic reticulum membrane protein degradation. Methods in Molecular Biology (Clifton, N.J.). 301: 185-205. PMID 15917633 DOI: 10.1385/1-59259-895-1:185 |
0.36 |
|
| 2005 |
Buck TM, Skach WR. Differential stability of biogenesis intermediates reveals a common pathway for aquaporin-1 topological maturation. The Journal of Biological Chemistry. 280: 261-9. PMID 15516332 DOI: 10.1074/jbc.M409920200 |
0.344 |
|
| 2004 |
Sadlish H, Skach WR. Biogenesis of CFTR and other polytopic membrane proteins: new roles for the ribosome-translocon complex. The Journal of Membrane Biology. 202: 115-26. PMID 15798900 DOI: 10.1007/S00232-004-0715-6 |
0.474 |
|
| 2002 |
Anthony V, Skach WR. Molecular mechanism of P-glycoprotein assembly into cellular membranes. Current Protein & Peptide Science. 3: 485-501. PMID 12369997 DOI: 10.2174/1389203023380503 |
0.347 |
|
| 2002 |
Carveth K, Buck T, Anthony V, Skach WR. Cooperativity and flexibility of cystic fibrosis transmembrane conductance regulator transmembrane segments participate in membrane localization of a charged residue. The Journal of Biological Chemistry. 277: 39507-14. PMID 12186867 DOI: 10.1074/jbc.M205759200 |
0.373 |
|
| 2000 |
Lu Y, Turnbull IR, Bragin A, Carveth K, Verkman AS, Skach WR. Reorientation of aquaporin-1 topology during maturation in the endoplasmic reticulum. Molecular Biology of the Cell. 11: 2973-85. PMID 10982394 |
0.441 |
|
| 2000 |
Foster W, Helm A, Turnbull I, Gulati H, Yang B, Verkman AS, Skach WR. Identification of sequence determinants that direct different intracellular folding pathways for aquaporin-1 and aquaporin-4. The Journal of Biological Chemistry. 275: 34157-65. PMID 10944517 DOI: 10.1074/jbc.M000165200 |
0.429 |
|
| 2000 |
Skach WR. Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator. Kidney International. 57: 825-31. PMID 10720935 DOI: 10.1046/j.1523-1755.2000.00921.x |
0.376 |
|
| 2000 |
Tu L, Wang J, Helm A, Skach WR, Deutsch C. Transmembrane biogenesis of Kv1.3. Biochemistry. 39: 824-36. PMID 10651649 DOI: 10.1021/Bi991740R |
0.303 |
|
| 1999 |
Xiong X, Chong E, Skach WR. Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the ER membrane. The Journal of Biological Chemistry. 274: 2616-24. PMID 9915789 DOI: 10.1074/jbc.274.5.2616 |
0.342 |
|
| 1998 |
Moss K, Helm A, Lu Y, Bragin A, Skach WR. Coupled translocation events generate topological heterogeneity at the endoplasmic reticulum membrane. Molecular Biology of the Cell. 9: 2681-97. PMID 9725920 |
0.39 |
|
| 1998 |
Lu Y, Xiong X, Helm A, Kimani K, Bragin A, Skach WR. Co- and posttranslational translocation mechanisms direct cystic fibrosis transmembrane conductance regulator N terminus transmembrane assembly. The Journal of Biological Chemistry. 273: 568-76. PMID 9417117 DOI: 10.1074/jbc.273.1.568 |
0.416 |
|
| 1997 |
Sheng Z, Skach W, Santarelli V, Deutsch C. Evidence for interaction between transmembrane segments in assembly of Kv1.3. Biochemistry. 36: 15501-13. PMID 9398279 DOI: 10.1021/Bi971490J |
0.367 |
|
| 1997 |
Xiong X, Bragin A, Widdicombe JH, Cohn J, Skach WR. Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator. The Journal of Clinical Investigation. 100: 1079-88. PMID 9276724 DOI: 10.1172/Jci119618 |
0.365 |
|
| 1996 |
Verkman AS, van Hoek AN, Ma T, Frigeri A, Skach WR, Mitra A, Tamarappoo BK, Farinas J. Water transport across mammalian cell membranes. The American Journal of Physiology. 270: C12-30. PMID 8772426 DOI: 10.1152/Ajpcell.1996.270.1.C12 |
0.351 |
|
| 1996 |
Tu L, Santarelli V, Sheng Z, Skach W, Pain D, Deutsch C. Voltage-gated K+ channels contain multiple intersubunit association sites. The Journal of Biological Chemistry. 271: 18904-11. PMID 8702552 DOI: 10.1074/Jbc.271.31.18904 |
0.308 |
|
| 1995 |
Verkman AS, Shi LB, Frigeri A, Hasegawa H, Farinas J, Mitra A, Skach W, Brown D, Van Hoek AN, Ma T. Structure and function of kidney water channels. Kidney International. 48: 1069-81. PMID 8569068 DOI: 10.1038/Ki.1995.390 |
0.45 |
|
| 1995 |
Shi LB, Skach WR, Ma T, Verkman AS. Distinct biogenesis mechanisms for the water channels MIWC and CHIP28 at the endoplasmic reticulum. Biochemistry. 34: 8250-6. PMID 7541239 DOI: 10.1021/Bi00026A006 |
0.5 |
|
| 1994 |
Skach WR, Lingappa VR. Transmembrane orientation and topogenesis of the third and fourth membrane-spanning regions of human P-glycoprotein (MDR1). Cancer Research. 54: 3202-9. PMID 7911395 |
0.623 |
|
| 1994 |
Skach WR, Shi LB, Calayag MC, Frigeri A, Lingappa VR, Verkman AS. Biogenesis and transmembrane topology of the CHIP28 water channel at the endoplasmic reticulum. The Journal of Cell Biology. 125: 803-15. PMID 7514605 DOI: 10.1083/Jcb.125.4.803 |
0.618 |
|
| 1994 |
Shi LB, Skach WR, Verkman AS. Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers. The Journal of Biological Chemistry. 269: 10417-22. PMID 7511600 |
0.338 |
|
| 1994 |
Ma T, Hasegawa H, Skach WR, Frigeri A, Verkman AS. Expression, functional analysis, and in situ hybridization of a cloned rat kidney collecting duct water channel. The American Journal of Physiology. 266: C189-97. PMID 7508187 |
0.338 |
|
| 1993 |
Zhang R, Skach W, Hasegawa H, van Hoek AN, Verkman AS. Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28. The Journal of Cell Biology. 120: 359-69. PMID 8421053 DOI: 10.1083/Jcb.120.2.359 |
0.458 |
|
| 1993 |
Skach WR, Calayag MC, Lingappa VR. Evidence for an alternate model of human P-glycoprotein structure and biogenesis. The Journal of Biological Chemistry. 268: 6903-8. PMID 8096508 |
0.597 |
|
| 1993 |
Skach WR, Lingappa VR. Amino-terminal assembly of human P-glycoprotein at the endoplasmic reticulum is directed by cooperative actions of two internal sequences. The Journal of Biological Chemistry. 268: 23552-61. PMID 7901209 |
0.618 |
|
| 1993 |
Ma T, Frigeri A, Skach W, Verkman AS. Cloning of a novel rat kidney cDNA homologous to CHIP28 and WCH-CD water channels. Biochemical and Biophysical Research Communications. 197: 654-9. PMID 7505572 DOI: 10.1006/Bbrc.1993.2529 |
0.446 |
|
| 1992 |
Hasegawa H, Skach W, Baker O, Calayag MC, Lingappa V, Verkman AS. A multifunctional aqueous channel formed by CFTR. Science (New York, N.Y.). 258: 1477-9. PMID 1279809 DOI: 10.1126/Science.1279809 |
0.556 |
|
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