| Year |
Citation |
Score |
| 2024 |
Dine E, Youle RJ. Integrating the response to stressed mitochondria. Molecular Cell. 84: 995-997. PMID 38518749 DOI: 10.1016/j.molcel.2024.02.026 |
0.537 |
|
| 2023 |
Fischer TD, Bunker EN, Zhu PP, Le Guerroué F, Dominguez-Martin E, Scavone F, Cohen R, Yao T, Wang Y, Werner A, Youle RJ. STING induces LUBAC-mediated synthesis of linear ubiquitin chains to stimulate innate immune signaling. Biorxiv : the Preprint Server For Biology. PMID 37873486 DOI: 10.1101/2023.10.14.562349 |
0.787 |
|
| 2023 |
Bunker EN, Le Guerroué F, Wang C, Strub MP, Werner A, Tjandra N, Youle RJ. Nix interacts with WIPI2 to induce mitophagy. The Embo Journal. e113491. PMID 37621214 DOI: 10.15252/embj.2023113491 |
0.827 |
|
| 2023 |
Moehlman AT, Kanfer G, Youle RJ. Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage. Plos Genetics. 19: e1010828. PMID 37440574 DOI: 10.1371/journal.pgen.1010828 |
0.619 |
|
| 2023 |
Le Guerroué F, Bunker EN, Rosencrans WM, Nguyen JT, Basar MA, Werner A, Chou TF, Wang C, Youle RJ. TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1. Molecular Cell. PMID 36898370 DOI: 10.1016/j.molcel.2023.02.023 |
0.813 |
|
| 2022 |
Vargas JNS, Hamasaki M, Kawabata T, Youle RJ, Yoshimori T. The mechanisms and roles of selective autophagy in mammals. Nature Reviews. Molecular Cell Biology. PMID 36302887 DOI: 10.1038/s41580-022-00542-2 |
0.564 |
|
| 2022 |
Sarraf SA, Shah HV, Kanfer G, Pickrell AM, Holtzclaw LA, Ward ME, Youle RJ. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Molecular Cell. 82: 1383-1385. PMID 35395199 DOI: 10.1016/j.molcel.2022.03.020 |
0.736 |
|
| 2021 |
Baldwin HA, Wang C, Kanfer G, Shah HV, Velayos-Baeza A, Dulovic-Mahlow M, Brüggemann N, Anding A, Baehrecke EH, Maric D, Prinz WA, Youle RJ. VPS13D promotes peroxisome biogenesis. The Journal of Cell Biology. 220. PMID 33891012 DOI: 10.1083/jcb.202001188 |
0.721 |
|
| 2021 |
Kanfer G, Sarraf SA, Maman Y, Baldwin H, Dominguez-Martin E, Johnson KR, Ward ME, Kampmann M, Lippincott-Schwartz J, Youle RJ. Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. The Journal of Cell Biology. 220. PMID 33464298 DOI: 10.1083/jcb.202006180 |
0.464 |
|
| 2020 |
Le Guerroué F, Youle RJ. Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective. Cell Death and Differentiation. PMID 33208890 DOI: 10.1038/s41418-020-00667-x |
0.792 |
|
| 2020 |
Sarraf SA, Shah HV, Kanfer G, Pickrell AM, Holtzclaw LA, Ward ME, Youle RJ. Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain. Molecular Cell. PMID 33207181 DOI: 10.1016/j.molcel.2020.10.041 |
0.761 |
|
| 2020 |
Fischer TD, Wang C, Padman BS, Lazarou M, Youle RJ. STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain. The Journal of Cell Biology. 219. PMID 33201170 DOI: 10.1083/jcb.202009128 |
0.79 |
|
| 2020 |
Borsche M, König IR, Delcambre S, Petrucci S, Balck A, Brüggemann N, Zimprich A, Wasner K, Pereira SL, Avenali M, Deuschle C, Badanjak K, Ghelfi J, Gasser T, Kasten M, ... Youle RJ, et al. Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism. Brain : a Journal of Neurology. PMID 33029617 DOI: 10.1093/brain/awaa246 |
0.523 |
|
| 2020 |
Moehlman AT, Youle RJ. Mitochondrial Quality Control and Restraining Innate Immunity. Annual Review of Cell and Developmental Biology. 36: 265-289. PMID 33021820 DOI: 10.1146/annurev-cellbio-021820-101354 |
0.613 |
|
| 2020 |
Yamano K, Youle RJ. Two different axes CALCOCO2-RB1CC1 and OPTN-ATG9A initiate PRKN-mediated mitophagy. Autophagy. 1-3. PMID 32892694 DOI: 10.1080/15548627.2020.1815457 |
0.65 |
|
| 2020 |
Shi X, Yokom AL, Wang C, Young LN, Youle RJ, Hurley JH. ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer. The Journal of Cell Biology. 219. PMID 32516362 DOI: 10.1083/Jcb.201911047 |
0.688 |
|
| 2019 |
Sarraf SA, Sideris DP, Giagtzoglou N, Ni L, Kankel MW, Sen A, Bochicchio LE, Huang CH, Nussenzweig SC, Worley SH, Morton PD, Artavanis-Tsakonas S, Youle RJ, Pickrell AM. PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Cell Reports. 29: 225-235.e5. PMID 31577952 DOI: 10.1016/J.Celrep.2019.08.085 |
0.816 |
|
| 2019 |
Youle RJ. Mitochondria-Striking a balance between host and endosymbiont. Science (New York, N.Y.). 365. PMID 31416937 DOI: 10.1126/Science.Aaw9855 |
0.629 |
|
| 2019 |
Lomash RM, Petralia RS, Holtzclaw LA, Tsuda MC, Wang YX, Badger JD, Cameron HA, Youle RJ, Roche KW. Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo. The Journal of Biological Chemistry. PMID 31177092 DOI: 10.1074/Jbc.Ra118.007245 |
0.673 |
|
| 2019 |
Vargas JNS, Wang C, Bunker E, Hao L, Maric D, Schiavo G, Randow F, Youle RJ. Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy. Molecular Cell. PMID 30853401 DOI: 10.1016/J.Molcel.2019.02.010 |
0.809 |
|
| 2019 |
Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ. Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1. Molecular Cell. PMID 30733118 DOI: 10.1016/J.Molcel.2019.01.002 |
0.83 |
|
| 2019 |
Ader NR, Hoffmann PC, Ganeva I, Borgeaud AC, Wang C, Youle RJ, Kukulski W. Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis. Elife. 8. PMID 30714902 DOI: 10.7554/Elife.40712 |
0.747 |
|
| 2019 |
Youle R. Mitochondria in Parkinson’s disease Journal of the Neurological Sciences. 405: 42. DOI: 10.1016/J.Jns.2019.10.115 |
0.368 |
|
| 2018 |
Samstag CL, Hoekstra JG, Huang CH, Chaisson MJ, Youle RJ, Kennedy SR, Pallanck LJ. Deleterious mitochondrial DNA point mutations are overrepresented in Drosophila expressing a proofreading-defective DNA polymerase γ. Plos Genetics. 14: e1007805. PMID 30452458 DOI: 10.1371/Journal.Pgen.1007805 |
0.598 |
|
| 2018 |
Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Parkin and PINK1 mitigate STING-induced inflammation. Nature. PMID 30135585 DOI: 10.1038/S41586-018-0448-9 |
0.811 |
|
| 2018 |
Le Guerroué F, Youle RJ. Active state of Parkin. Nature Structural & Molecular Biology. PMID 30038392 DOI: 10.1038/S41594-018-0101-1 |
0.774 |
|
| 2018 |
Sarraf SA, Youle RJ. Parkin mediates mitophagy during beige-to-white fat conversion. Science Signaling. 11. PMID 29692360 DOI: 10.1126/Scisignal.Aat1082 |
0.554 |
|
| 2018 |
Pickles S, Vigié P, Youle RJ. Mitophagy and Quality Control Mechanisms in Mitochondrial Maintenance. Current Biology : Cb. 28: R170-R185. PMID 29462587 DOI: 10.1016/J.Cub.2018.01.004 |
0.687 |
|
| 2018 |
Yamano K, Wang C, Sarraf SA, Münch C, Kikuchi R, Noda NN, Hizukuri Y, Kanemaki MT, Harper W, Tanaka K, Matsuda N, Youle RJ. Endosomal Rab cycles regulate Parkin-mediated mitophagy. Elife. 7. PMID 29360040 DOI: 10.7554/Elife.31326 |
0.799 |
|
| 2018 |
Sekine S, Youle RJ. PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol. Bmc Biology. 16: 2. PMID 29325568 DOI: 10.1186/S12915-017-0470-7 |
0.676 |
|
| 2018 |
Ader NR, Hoffmann PC, Ganeva I, Borgeaud AC, Wang C, Youle RJ, Kukulski W. Author response: Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis Elife. DOI: 10.7554/Elife.40712.039 |
0.705 |
|
| 2018 |
Youle RJ. Roles of endogenous PINK1 and Parkin in vivo – a different type of mitochondrial QC Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1859: e7. DOI: 10.1016/J.Bbabio.2018.09.022 |
0.648 |
|
| 2017 |
Anding AL, Wang C, Chang TK, Sliter DA, Powers CM, Hofmann K, Youle RJ, Baehrecke EH. Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. Current Biology : Cb. PMID 29307555 DOI: 10.1016/J.Cub.2017.11.064 |
0.796 |
|
| 2017 |
Burman JL, Pickles S, Wang C, Sekine S, Vargas JNS, Zhang Z, Youle AM, Nezich CL, Wu X, Hammer JA, Youle RJ. Mitochondrial fission facilitates the selective mitophagy of protein aggregates. The Journal of Cell Biology. PMID 28893839 DOI: 10.1083/Jcb.201612106 |
0.795 |
|
| 2016 |
Stolz A, Putyrski M, Kutle I, Huber J, Wang C, Major V, Sidhu SS, Youle RJ, Rogov VV, Dötsch V, Ernst A, Dikic I. Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. The Embo Journal. PMID 28028054 DOI: 10.15252/Embj.201695063 |
0.7 |
|
| 2016 |
Murphy E, Ardehali H, Balaban RS, DiLisa F, Dorn GW, Kitsis RN, Otsu K, Ping P, Rizzuto R, Sack MN, Wallace D, Youle RJ. Mitochondrial Function, Biology, and Role in Disease: A Scientific Statement From the American Heart Association. Circulation Research. 118: 1960-91. PMID 27126807 DOI: 10.1161/Res.0000000000000104 |
0.638 |
|
| 2016 |
Richter B, Sliter DA, Herhaus L, Stolz A, Wang C, Beli P, Zaffagnini G, Wild P, Martens S, Wagner SA, Youle RJ, Dikic I. Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035970 DOI: 10.1073/Pnas.1523926113 |
0.742 |
|
| 2016 |
Sun N, Youle RJ, Finkel T. The Mitochondrial Basis of Aging. Molecular Cell. 61: 654-66. PMID 26942670 DOI: 10.1016/J.Molcel.2016.01.028 |
0.633 |
|
| 2016 |
Yao Y, Nisan D, Antignani A, Barnes A, Tjandra N, Youle RJ, Marassi FM, Fujimoto LM. Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL. Protein Expression and Purification. 122: 56-63. PMID 26923059 DOI: 10.1016/J.Pep.2016.02.010 |
0.592 |
|
| 2016 |
Wang C, Youle R. Cell biology: Form follows function for mitochondria. Nature. 530: 288-9. PMID 26887490 DOI: 10.1038/530288A |
0.759 |
|
| 2015 |
Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy. Nature. 524: 309-14. PMID 26266977 DOI: 10.1038/Nature14893 |
0.838 |
|
| 2015 |
Nezich CL, Wang C, Fogel AI, Youle RJ. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. The Journal of Cell Biology. 210: 435-50. PMID 26240184 DOI: 10.1083/Jcb.201501002 |
0.763 |
|
| 2015 |
Lomash RM, Gu X, Youle RJ, Lu W, Roche KW. Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density. Cell Reports. PMID 26212327 DOI: 10.1016/J.Celrep.2015.06.064 |
0.551 |
|
| 2015 |
Pickrell AM, Huang CH, Kennedy SR, Ordureau A, Sideris DP, Hoekstra JG, Harper JW, Youle RJ. Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron. 87: 371-81. PMID 26182419 DOI: 10.1016/J.Neuron.2015.06.034 |
0.783 |
|
| 2015 |
Yao Y, Fujimoto LM, Hirshman N, Bobkov AA, Antignani A, Youle RJ, Marassi FM. Conformation of BCL-XL upon Membrane Integration. Journal of Molecular Biology. 427: 2262-70. PMID 25731750 DOI: 10.1016/J.Jmb.2015.02.019 |
0.572 |
|
| 2015 |
Hasson SA, Fogel AI, Wang C, MacArthur R, Guha R, Heman-Ackah S, Martin S, Youle RJ, Inglese J. Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter. Acs Chemical Biology. 10: 1188-97. PMID 25689131 DOI: 10.1021/Cb5010417 |
0.724 |
|
| 2015 |
Pickrell AM, Youle RJ. The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron. 85: 257-73. PMID 25611507 DOI: 10.1016/J.Neuron.2014.12.007 |
0.813 |
|
| 2015 |
Sousa T, Coutinho A, Banerjee S, Castro R, Youle R, Rodrigues C, Prieto M, Fernandes F. Binding of Pro-Apoptotic Protein Bax to Cytoprotective UDCA and TUDCA Biophysical Journal. 108: 608a-609a. DOI: 10.1016/J.Bpj.2014.11.3313 |
0.61 |
|
| 2014 |
Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. The Journal of Cell Biology. 205: 143-53. PMID 24751536 DOI: 10.1083/Jcb.201402104 |
0.768 |
|
| 2014 |
Randow F, Youle RJ. Self and nonself: how autophagy targets mitochondria and bacteria. Cell Host & Microbe. 15: 403-11. PMID 24721569 DOI: 10.1016/J.Chom.2014.03.012 |
0.609 |
|
| 2014 |
Yamano K, Fogel AI, Wang C, van der Bliek AM, Youle RJ. Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy. Elife. 3: e01612. PMID 24569479 DOI: 10.7554/Elife.01612 |
0.791 |
|
| 2014 |
Shen Q, Yamano K, Head BP, Kawajiri S, Cheung JT, Wang C, Cho JH, Hattori N, Youle RJ, van der Bliek AM. Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Molecular Biology of the Cell. 25: 145-59. PMID 24196833 DOI: 10.1091/Mbc.E13-09-0525 |
0.8 |
|
| 2014 |
Yamano K, Fogel AI, Wang C, Bliek AMvd, Youle RJ. Author response: Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy Elife. DOI: 10.7554/Elife.01612.028 |
0.69 |
|
| 2013 |
Pickrell AM, Youle RJ. Mitochondrial disease: mtDNA and protein segregation mysteries in iPSCs. Current Biology : Cb. 23: R1052-4. PMID 24309284 DOI: 10.1016/J.Cub.2013.10.048 |
0.797 |
|
| 2013 |
Hasson SA, Kane LA, Yamano K, Huang CH, Sliter DA, Buehler E, Wang C, Heman-Ackah SM, Hessa T, Guha R, Martin SE, Youle RJ. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. Nature. 504: 291-5. PMID 24270810 DOI: 10.1038/Nature12748 |
0.775 |
|
| 2013 |
Abeliovich H, Zarei M, Rigbolt KT, Youle RJ, Dengjel J. Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy. Nature Communications. 4: 2789. PMID 24240771 DOI: 10.1038/Ncomms3789 |
0.673 |
|
| 2013 |
Jin SM, Youle RJ. The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria. Autophagy. 9: 1750-7. PMID 24149988 DOI: 10.4161/Auto.26122 |
0.694 |
|
| 2013 |
Yamano K, Youle RJ. PINK1 is degraded through the N-end rule pathway. Autophagy. 9: 1758-69. PMID 24121706 DOI: 10.4161/Auto.24633 |
0.644 |
|
| 2013 |
Stavru F, Palmer AE, Wang C, Youle RJ, Cossart P. Atypical mitochondrial fission upon bacterial infection. Proceedings of the National Academy of Sciences of the United States of America. 110: 16003-8. PMID 24043775 DOI: 10.1073/Pnas.1315784110 |
0.799 |
|
| 2013 |
Fogel AI, Dlouhy BJ, Wang C, Ryu SW, Neutzner A, Hasson SA, Sideris DP, Abeliovich H, Youle RJ. Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Molecular and Cellular Biology. 33: 3675-88. PMID 23878393 DOI: 10.1128/Mcb.00079-13 |
0.739 |
|
| 2013 |
Nezich CL, Youle RJ. Make or break for mitochondria. Elife. 2: e00804. PMID 23682317 DOI: 10.7554/Elife.00804 |
0.635 |
|
| 2013 |
Huang CH, Lazarou M, Youle RJ. Sequestration and autophagy of mitochondria do not cut proteins across the board. Proceedings of the National Academy of Sciences of the United States of America. 110: 6252-3. PMID 23569251 DOI: 10.1073/Pnas.1303921110 |
0.806 |
|
| 2013 |
Narendra DP, Wang C, Youle RJ, Walker JE. PINK1 rendered temperature sensitive by disease-associated and engineered mutations. Human Molecular Genetics. 22: 2572-89. PMID 23459931 DOI: 10.1093/Hmg/Ddt106 |
0.832 |
|
| 2013 |
Lazarou M, Narendra DP, Jin SM, Tekle E, Banerjee S, Youle RJ. PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding. The Journal of Cell Biology. 200: 163-72. PMID 23319602 DOI: 10.1083/Jcb.201210111 |
0.837 |
|
| 2013 |
Todt F, Cakir Z, Reichenbach F, Youle RJ, Edlich F. The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria. Cell Death and Differentiation. 20: 333-42. PMID 23079612 DOI: 10.1038/Cdd.2012.131 |
0.439 |
|
| 2013 |
Pickrell AM, Huang C, Pinto M, Moraes CT, Youle RJ. Therapy for mitochondrial diseases: An investigation into the potential to stimulate Parkin-mediated mitophagy Mitochondrion. 13: 943. DOI: 10.1016/J.Mito.2013.07.111 |
0.815 |
|
| 2013 |
Milena P, Pickrell AM, Youle RJ, Moraes CT. The role of Parkin in the clearance of defective mitochondria with deleted mtDNA in the CNS Mitochondrion. 13: 935. DOI: 10.1016/J.Mito.2013.07.095 |
0.815 |
|
| 2012 |
Cooper JP, Youle RJ. Balancing cell growth and death. Current Opinion in Cell Biology. 24: 802-3. PMID 23246130 DOI: 10.1016/J.Ceb.2012.11.003 |
0.586 |
|
| 2012 |
Ma J, Edlich F, Bermejo GA, Norris KL, Youle RJ, Tjandra N. Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proceedings of the National Academy of Sciences of the United States of America. 109: 20901-6. PMID 23213219 DOI: 10.1073/Pnas.1217094110 |
0.775 |
|
| 2012 |
Lussier MP, Herring BE, Nasu-Nishimura Y, Neutzner A, Karbowski M, Youle RJ, Nicoll RA, Roche KW. Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 109: 19426-31. PMID 23129617 DOI: 10.1073/Pnas.1217477109 |
0.537 |
|
| 2012 |
Narendra D, Walker JE, Youle R. Mitochondrial quality control mediated by PINK1 and Parkin: links to parkinsonism. Cold Spring Harbor Perspectives in Biology. 4. PMID 23125018 DOI: 10.1101/Cshperspect.A011338 |
0.849 |
|
| 2012 |
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Youle RJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496 |
0.756 |
|
| 2012 |
Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress. Science (New York, N.Y.). 337: 1062-5. PMID 22936770 DOI: 10.1126/Science.1219855 |
0.653 |
|
| 2012 |
Perciavalle RM, Stewart DP, Koss B, Lynch J, Milasta S, Bathina M, Temirov J, Cleland MM, Pelletier S, Schuetz JD, Youle RJ, Green DR, Opferman JT. Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration Nature Cell Biology. 14: 575-583. PMID 22544066 DOI: 10.1038/Ncb2488 |
0.694 |
|
| 2012 |
Jin SM, Youle RJ. PINK1- and Parkin-mediated mitophagy at a glance. Journal of Cell Science. 125: 795-9. PMID 22448035 DOI: 10.1242/Jcs.093849 |
0.588 |
|
| 2012 |
Narendra DP, Youle RJ. Neurodegeneration: Trouble in the cell's powerhouse. Nature. 483: 418-9. PMID 22398449 DOI: 10.1038/Nature10952 |
0.763 |
|
| 2012 |
Sims JJ, Scavone F, Cooper EM, Kane LA, Youle RJ, Boeke JD, Cohen RE. Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nature Methods. 9: 303-9. PMID 22306808 DOI: 10.1038/Nmeth.1888 |
0.577 |
|
| 2012 |
Lazarou M, Jin SM, Kane LA, Youle RJ. Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Developmental Cell. 22: 320-33. PMID 22280891 DOI: 10.1016/J.Devcel.2011.12.014 |
0.803 |
|
| 2012 |
Wang C, Youle RJ. Predominant requirement of Bax for apoptosis in HCT116 cells is determined by Mcl-1's inhibitory effect on Bak. Oncogene. 31: 3177-89. PMID 22056880 DOI: 10.1038/Onc.2011.497 |
0.763 |
|
| 2012 |
Gorbatyuk VY, Chen YC, Wu YJ, Youle RJ, Huang TH. Letter to the Editor: Sequence-specific 1H, 13C and 15N resonance assignments of recombinant onconase/P-30 protein. Journal of Biomolecular Nmr. 15: 343-4. PMID 20703857 DOI: 10.1023/A:1008312325225 |
0.491 |
|
| 2012 |
Youle RJ. Damage control — How the PINK1/Parkin pathway can regulate removal of impaired mitochondria by autophagy Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1817: S3. DOI: 10.1016/J.Bbabio.2012.06.018 |
0.621 |
|
| 2011 |
Kane LA, Youle RJ. PINK1 and Parkin flag Miro to direct mitochondrial traffic. Cell. 147: 721-3. PMID 22078873 DOI: 10.1016/J.Cell.2011.10.028 |
0.677 |
|
| 2011 |
Yamano K, Youle RJ. Coupling mitochondrial and cell division. Nature Cell Biology. 13: 1026-7. PMID 21892144 DOI: 10.1038/Ncb2334 |
0.663 |
|
| 2011 |
Kim KY, Stevens MV, Akter MH, Rusk SE, Huang RJ, Cohen A, Noguchi A, Springer D, Bocharov AV, Eggerman TL, Suen DF, Youle RJ, Amar M, Remaley AT, Sack MN. Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. The Journal of Clinical Investigation. 121: 3701-12. PMID 21865652 DOI: 10.1172/Jci44736 |
0.759 |
|
| 2011 |
Joo JH, Dorsey FC, Joshi A, Hennessy-Walters KM, Rose KL, McCastlain K, Zhang J, Iyengar R, Jung CH, Suen DF, Steeves MA, Yang CY, Prater SM, Kim DH, Thompson CB, ... Youle RJ, et al. Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Molecular Cell. 43: 572-85. PMID 21855797 DOI: 10.1016/J.Molcel.2011.06.018 |
0.814 |
|
| 2011 |
Martinou JC, Youle RJ. Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Developmental Cell. 21: 92-101. PMID 21763611 DOI: 10.1016/J.Devcel.2011.06.017 |
0.691 |
|
| 2011 |
Karbowski M, Youle RJ. Regulating mitochondrial outer membrane proteins by ubiquitination and proteasomal degradation. Current Opinion in Cell Biology. 23: 476-82. PMID 21705204 DOI: 10.1016/J.Ceb.2011.05.007 |
0.666 |
|
| 2011 |
Edlich F, Banerjee S, Suzuki M, Cleland MM, Arnoult D, Wang C, Neutzner A, Tjandra N, Youle RJ. Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell. 145: 104-16. PMID 21458670 DOI: 10.1016/J.Cell.2011.02.034 |
0.788 |
|
| 2011 |
Carelli V, Schimpf S, Fuhrmann N, Valentino ML, Zanna C, Iommarini L, Papke M, Schaich S, Tippmann S, Baumann B, Barboni P, Longanesi L, Rugolo M, Ghelli A, Alavi MV, ... Youle RJ, et al. A clinically complex form of dominant optic atrophy (OPA8) maps on chromosome 16. Human Molecular Genetics. 20: 1893-905. PMID 21349918 DOI: 10.1093/Hmg/Ddr071 |
0.615 |
|
| 2011 |
Hoppins S, Edlich F, Cleland MM, Banerjee S, McCaffery JM, Youle RJ, Nunnari J. The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Molecular Cell. 41: 150-60. PMID 21255726 DOI: 10.1016/J.Molcel.2010.11.030 |
0.666 |
|
| 2011 |
Neutzner A, Neutzner M, Benischke AS, Ryu SW, Frank S, Youle RJ, Karbowski M. A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. The Journal of Biological Chemistry. 286: 8633-43. PMID 21205830 DOI: 10.1074/Jbc.M110.197459 |
0.573 |
|
| 2011 |
Narendra DP, Youle RJ. Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxidants & Redox Signaling. 14: 1929-38. PMID 21194381 DOI: 10.1089/Ars.2010.3799 |
0.835 |
|
| 2011 |
Youle RJ, Narendra DP. Mechanisms of mitophagy. Nature Reviews. Molecular Cell Biology. 12: 9-14. PMID 21179058 DOI: 10.1038/Nrm3028 |
0.801 |
|
| 2011 |
Cleland MM, Norris KL, Karbowski M, Wang C, Suen DF, Jiao S, George NM, Luo X, Li Z, Youle RJ. Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death and Differentiation. 18: 235-47. PMID 20671748 DOI: 10.1038/Cdd.2010.89 |
0.841 |
|
| 2011 |
Tjandra N, Ma J, Edlich F, Youle R. Structural Insights into Cytomegalovirus Resistance to Apoptosis Biophysical Journal. 100: 17a. DOI: 10.1016/J.Bpj.2010.12.302 |
0.639 |
|
| 2010 |
Tanaka A, Cleland MM, Xu S, Narendra DP, Suen DF, Karbowski M, Youle RJ. Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin. The Journal of Cell Biology. 191: 1367-80. PMID 21173115 DOI: 10.1083/Jcb.201007013 |
0.85 |
|
| 2010 |
Otera H, Wang C, Cleland MM, Setoguchi K, Yokota S, Youle RJ, Mihara K. Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. The Journal of Cell Biology. 191: 1141-58. PMID 21149567 DOI: 10.1083/Jcb.201007152 |
0.797 |
|
| 2010 |
Jin SM, Lazarou M, Wang C, Kane LA, Narendra DP, Youle RJ. Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. The Journal of Cell Biology. 191: 933-42. PMID 21115803 DOI: 10.1083/Jcb.201008084 |
0.848 |
|
| 2010 |
Narendra DP, Kane LA, Hauser DN, Fearnley IM, Youle RJ. p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both Autophagy. 6: 1090-1106. PMID 20890124 DOI: 10.4161/Auto.6.8.13426 |
0.824 |
|
| 2010 |
Kane LA, Youle RJ. Mitochondrial fission and fusion and their roles in the heart. Journal of Molecular Medicine (Berlin, Germany). 88: 971-9. PMID 20835916 DOI: 10.1007/S00109-010-0674-6 |
0.644 |
|
| 2010 |
Suen DF, Narendra DP, Tanaka A, Manfredi G, Youle RJ. Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 11835-40. PMID 20547844 DOI: 10.1073/Pnas.0914569107 |
0.836 |
|
| 2010 |
Scott I, Youle RJ. Mitochondrial fission and fusion. Essays in Biochemistry. 47: 85-98. PMID 20533902 DOI: 10.1042/Bse0470085 |
0.686 |
|
| 2010 |
Du X, Youle RJ, FitzGerald DJ, Pastan I. Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. Molecular and Cellular Biology. 30: 3444-52. PMID 20457813 DOI: 10.1128/Mcb.00813-09 |
0.652 |
|
| 2010 |
Benard G, Neutzner A, Peng G, Wang C, Livak F, Youle RJ, Karbowski M. IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. The Embo Journal. 29: 1458-71. PMID 20300062 DOI: 10.1038/Emboj.2010.39 |
0.787 |
|
| 2010 |
Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. Plos Biology. 8: e1000298. PMID 20126261 DOI: 10.1371/Journal.Pbio.1000298 |
0.847 |
|
| 2010 |
Park YY, Lee S, Karbowski M, Neutzner A, Youle RJ, Cho H. Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. Journal of Cell Science. 123: 619-26. PMID 20103533 DOI: 10.1242/Jcs.061481 |
0.698 |
|
| 2010 |
Narendra DP, Jin SM, Tanaka A, Suen D, Gautier CA, Shen J, Cookson MR, Youle RJ. PINK1 selectively accumulates on depolarized mitochondria. Plos Biology. DOI: 10.1371/Journal.Pbio.1000298.G001 |
0.773 |
|
| 2010 |
Youle RJ. Role of the mitochondrial kinase Pink1 in Parkin recruitment and mitophagy Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1797: 141. DOI: 10.1016/J.Bbabio.2010.04.421 |
0.646 |
|
| 2009 |
Rostovtseva TK, Boukari H, Antignani A, Shiu B, Banerjee S, Neutzner A, Youle RJ. Bax activates endophilin B1 oligomerization and lipid membrane vesiculation. The Journal of Biological Chemistry. 284: 34390-9. PMID 19805544 DOI: 10.1074/Jbc.M109.021873 |
0.605 |
|
| 2009 |
Wang C, Youle RJ. The role of mitochondria in apoptosis*. Annual Review of Genetics. 43: 95-118. PMID 19659442 DOI: 10.1146/Annurev-Genet-102108-134850 |
0.776 |
|
| 2009 |
Hardwick JM, Youle RJ. SnapShot: BCL-2 proteins. Cell. 138: 404, 404.e1. PMID 19632186 DOI: 10.1016/J.Cell.2009.07.003 |
0.632 |
|
| 2009 |
Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy. 5: 706-8. PMID 19377297 DOI: 10.4161/Auto.5.5.8505 |
0.84 |
|
| 2009 |
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, ... Youle RJ, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differentiation. 16: 1093-107. PMID 19373242 DOI: 10.1038/Cdd.2009.44 |
0.565 |
|
| 2009 |
Tondera D, Grandemange S, Jourdain A, Karbowski M, Mattenberger Y, Herzig S, Da Cruz S, Clerc P, Raschke I, Merkwirth C, Ehses S, Krause F, Chan DC, Alexander C, Bauer C, ... Youle R, et al. SLP-2 is required for stress-induced mitochondrial hyperfusion. The Embo Journal. 28: 1589-600. PMID 19360003 DOI: 10.1038/Emboj.2009.89 |
0.685 |
|
| 2008 |
Neutzner A, Benard G, Youle RJ, Karbowski M. Role of the ubiquitin conjugation system in the maintenance of mitochondrial homeostasis. Annals of the New York Academy of Sciences. 1147: 242-53. PMID 19076446 DOI: 10.1196/Annals.1427.012 |
0.704 |
|
| 2008 |
Narendra D, Tanaka A, Suen DF, Youle RJ. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. The Journal of Cell Biology. 183: 795-803. PMID 19029340 DOI: 10.1083/Jcb.200809125 |
0.847 |
|
| 2008 |
Suen DF, Norris KL, Youle RJ. Mitochondrial dynamics and apoptosis. Genes & Development. 22: 1577-90. PMID 18559474 DOI: 10.1101/Gad.1658508 |
0.848 |
|
| 2008 |
Antignani A, Youle RJ. Endosome fusion induced by diphtheria toxin translocation domain. Proceedings of the National Academy of Sciences of the United States of America. 105: 8020-5. PMID 18539770 DOI: 10.1073/Pnas.0711707105 |
0.573 |
|
| 2008 |
Norris KL, Youle RJ. Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. Journal of Virology. 82: 6232-43. PMID 18417572 DOI: 10.1128/Jvi.02710-07 |
0.766 |
|
| 2008 |
Tanaka A, Youle RJ. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Molecular Cell. 29: 409-10. PMID 18313377 DOI: 10.1016/J.Molcel.2008.02.005 |
0.686 |
|
| 2008 |
Zanna C, Ghelli A, Porcelli AM, Karbowski M, Youle RJ, Schimpf S, Wissinger B, Pinti M, Cossarizza A, Vidoni S, Valentino ML, Rugolo M, Carelli V. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. Brain : a Journal of Neurology. 131: 352-67. PMID 18222991 DOI: 10.1093/Brain/Awm335 |
0.665 |
|
| 2008 |
Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nature Reviews. Molecular Cell Biology. 9: 47-59. PMID 18097445 DOI: 10.1038/Nrm2308 |
0.591 |
|
| 2008 |
Cleland MM, Suen D, Norris KL, Ryu S, Youle RJ. S9.8 Mitofusin foci: Endogenous localization and apoptotic behavior Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1777: S56-S57. DOI: 10.1016/J.Bbabio.2008.05.223 |
0.764 |
|
| 2008 |
Thomas KJ, Sandebring A, Beilina A, van der Brug M, Cleland MM, Zambrano I, Miller DW, Unger C, Cowburn R, Youle R, Behbahani H, Cedazo-Mínguez A, Cookson MR. S9.4 Altered mitochondrial dynamics caused by loss of PTEN-induced kinase 1 function, associated with recessive parkinsonism, are reversed by downregulation of Dynamin-related protein 1 Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1777: S55. DOI: 10.1016/J.Bbabio.2008.05.219 |
0.641 |
|
| 2007 |
Neutzner A, Youle RJ, Karbowski M. Outer mitochondrial membrane protein degradation by the proteasome. Novartis Foundation Symposium. 287: 4-14; discussion 14-. PMID 18074628 DOI: 10.1002/9780470725207.Ch2 |
0.688 |
|
| 2007 |
Karbowski M, Neutzner A, Youle RJ. The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. The Journal of Cell Biology. 178: 71-84. PMID 17606867 DOI: 10.1083/Jcb.200611064 |
0.694 |
|
| 2007 |
Lee S, Jeong SY, Lim WC, Kim S, Park YY, Sun X, Youle RJ, Cho H. Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. The Journal of Biological Chemistry. 282: 22977-83. PMID 17545159 DOI: 10.1074/Jbc.M700679200 |
0.695 |
|
| 2007 |
Goyal G, Fell B, Sarin A, Youle RJ, Sriram V. Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster. Developmental Cell. 12: 807-16. PMID 17488630 DOI: 10.1016/J.Devcel.2007.02.002 |
0.679 |
|
| 2007 |
Antignani A, Youle RJ. The cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), can deliver Bcl-XL as an extracellular fusion protein to protect cells from apoptosis and retain differentiation induction. The Journal of Biological Chemistry. 282: 11246-54. PMID 17311927 DOI: 10.1074/Jbc.M609824200 |
0.589 |
|
| 2007 |
Youle RJ. Cell biology. Cellular demolition and the rules of engagement. Science (New York, N.Y.). 315: 776-7. PMID 17289967 DOI: 10.1126/Science.1138870 |
0.576 |
|
| 2007 |
Youle RJ. The molecular interrelationships between mitochondrial morphogenesis and apoptosis The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A96-C |
0.498 |
|
| 2007 |
Neutzner A, Karbowski M, Youle RJ. Mitochondrial morphology is regulated by RING domain proteins. The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A661-B |
0.456 |
|
| 2007 |
Cleland MM, Ryu S, Karbowski M, Youle R. State of GTPase cycle dictates mobility and localization of large mitochondrial GTPases, Mfn1 and 2 The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A661-A |
0.625 |
|
| 2007 |
Boukari H, Shiu B, Banerjee S, Silver J, Youle RJ, Bezrukov SM, Rostovtseva TK. Fluorescence based studies of endophilin B proteins and their interactions with lipid membranes The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A258 |
0.518 |
|
| 2006 |
Antignani A, Youle RJ. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Current Opinion in Cell Biology. 18: 685-9. PMID 17046225 DOI: 10.1016/J.Ceb.2006.10.004 |
0.647 |
|
| 2006 |
Karbowski M, Norris KL, Cleland MM, Jeong SY, Youle RJ. Role of Bax and Bak in mitochondrial morphogenesis. Nature. 443: 658-62. PMID 17035996 DOI: 10.1038/Nature05111 |
0.79 |
|
| 2006 |
Barsoum MJ, Yuan H, Gerencser AA, Liot G, Kushnareva Y, Gräber S, Kovacs I, Lee WD, Waggoner J, Cui J, White AD, Bossy B, Martinou JC, Youle RJ, Lipton SA, et al. Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. The Embo Journal. 25: 3900-11. PMID 16874299 DOI: 10.1038/Sj.Emboj.7601253 |
0.653 |
|
| 2006 |
Martinou JC, Youle RJ. Which came first, the cytochrome c release or the mitochondrial fission? Cell Death and Differentiation. 13: 1291-5. PMID 16763618 DOI: 10.1038/Sj.Cdd.4401985 |
0.622 |
|
| 2006 |
House SB, Rusnak M, Liu XH, Youle RJ, Gainer H. Bcl-xL and caspase inhibition increase the survival of rat oxytocin and vasopressin magnocellular neurons in organotypic culture. Experimental Neurology. 200: 267-71. PMID 16624298 DOI: 10.1016/J.Expneurol.2006.02.009 |
0.595 |
|
| 2005 |
Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG. Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Molecular and Cellular Biology. 25: 9369-82. PMID 16227588 DOI: 10.1128/Mcb.25.21.9369-9382.2005 |
0.659 |
|
| 2005 |
Youle RJ, Karbowski M. Mitochondrial fission in apoptosis. Nature Reviews. Molecular Cell Biology. 6: 657-63. PMID 16025099 DOI: 10.1038/Nrm1697 |
0.682 |
|
| 2005 |
Suzuki M, Neutzner A, Tjandra N, Youle RJ. Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission. The Journal of Biological Chemistry. 280: 21444-52. PMID 15809300 DOI: 10.1074/Jbc.M414092200 |
0.607 |
|
| 2005 |
Neutzner A, Youle RJ. Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 280: 18598-603. PMID 15760898 DOI: 10.1074/Jbc.M500807200 |
0.679 |
|
| 2005 |
Antignani A, Youle RJ. A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad. Biochemistry. 44: 4074-82. PMID 15751984 DOI: 10.1021/Bi0477687 |
0.597 |
|
| 2005 |
Youle RJ. Morphology of mitochondria during apoptosis: worms-to-beetles in worms. Developmental Cell. 8: 298-9. PMID 15737923 DOI: 10.1016/J.Devcel.2005.02.003 |
0.659 |
|
| 2005 |
Nesic-Taylor O, Cittelly D, Ye Z, Xu GY, Unabia G, Lee JC, Svrakic NM, Liu XH, Youle RJ, Wood TG, McAdoo D, Westlund KN, Hulsebosch CE, Perez-Polo JR. Exogenous Bcl-xL fusion protein spares neurons after spinal cord injury. Journal of Neuroscience Research. 79: 628-37. PMID 15668909 DOI: 10.1002/Jnr.20400 |
0.523 |
|
| 2004 |
Carvalho AC, Sharpe J, Rosenstock TR, Teles AF, Youle RJ, Smaili SS. Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation. Cell Death and Differentiation. 11: 1265-76. PMID 15499375 DOI: 10.1038/Sj.Cdd.4401508 |
0.611 |
|
| 2004 |
Szabadkai G, Simoni AM, Chami M, Wieckowski MR, Youle RJ, Rizzuto R. Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. Molecular Cell. 16: 59-68. PMID 15469822 DOI: 10.1016/J.Molcel.2004.09.026 |
0.631 |
|
| 2004 |
Karbowski M, Jeong SY, Youle RJ. Endophilin B1 is required for the maintenance of mitochondrial morphology. The Journal of Cell Biology. 166: 1027-39. PMID 15452144 DOI: 10.1083/Jcb.200407046 |
0.67 |
|
| 2004 |
Lee YJ, Jeong SY, Karbowski M, Smith CL, Youle RJ. Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Molecular Biology of the Cell. 15: 5001-11. PMID 15356267 DOI: 10.1091/Mbc.E04-04-0294 |
0.698 |
|
| 2004 |
Arnoult D, Bartle LM, Skaletskaya A, Poncet D, Zamzami N, Park PU, Sharpe J, Youle RJ, Goldmacher VS. Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 101: 7988-93. PMID 15148411 DOI: 10.1073/Pnas.0401897101 |
0.705 |
|
| 2004 |
Hofmann SR, Lam AQ, Frank S, Zhou YJ, Ramos HL, Kanno Y, Agnello D, Youle RJ, O'Shea JJ. Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited. Molecular and Cellular Biology. 24: 5039-49. PMID 15143194 DOI: 10.1128/Mcb.24.11.5039-5049.2004 |
0.542 |
|
| 2004 |
Jeong SY, Gaume B, Lee YJ, Hsu YT, Ryu SW, Yoon SH, Youle RJ. Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. The Embo Journal. 23: 2146-55. PMID 15131699 DOI: 10.1038/Sj.Emboj.7600225 |
0.564 |
|
| 2004 |
Sharpe JC, Arnoult D, Youle RJ. Control of mitochondrial permeability by Bcl-2 family members. Biochimica Et Biophysica Acta. 1644: 107-13. PMID 14996495 DOI: 10.1016/J.Bbamcr.2003.10.016 |
0.589 |
|
| 2004 |
Karbowski M, Arnoult D, Chen H, Chan DC, Smith CL, Youle RJ. Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. The Journal of Cell Biology. 164: 493-9. PMID 14769861 DOI: 10.1083/Jcb.200309082 |
0.699 |
|
| 2004 |
Rostovtseva TK, Antonsson B, Suzuki M, Youle RJ, Colombini M, Bezrukov SM. Bid, but not Bax, regulates VDAC channels. The Journal of Biological Chemistry. 279: 13575-83. PMID 14729675 DOI: 10.1074/Jbc.M310593200 |
0.644 |
|
| 2004 |
Carvalho ACP, Sharpe J, Rosenstock TR, Teles AFV, Kowaltowski AJ, Youle RJ, Smaili SS. Erratum: Bax affects intracellular Ca2+ stores and induces Ca2+ wave propagation Cell Death & Differentiation. 12: 105-105. DOI: 10.1038/Sj.Cdd.4401550 |
0.505 |
|
| 2003 |
Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N. The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. Journal of Molecular Biology. 334: 445-58. PMID 14623186 DOI: 10.1016/J.Jmb.2003.09.064 |
0.653 |
|
| 2003 |
Arnoult D, Gaume B, Karbowski M, Sharpe JC, Cecconi F, Youle RJ. Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. The Embo Journal. 22: 4385-99. PMID 12941691 DOI: 10.1093/Emboj/Cdg423 |
0.684 |
|
| 2003 |
Karbowski M, Youle RJ. Dynamics of mitochondrial morphology in healthy cells and during apoptosis. Cell Death and Differentiation. 10: 870-80. PMID 12867994 DOI: 10.1038/Sj.Cdd.4401260 |
0.695 |
|
| 2003 |
Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B, Alix S, Youle RJ, LaMarche A, Maroney AC, Johnson EM. JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron. 38: 899-914. PMID 12818176 DOI: 10.1016/S0896-6273(03)00355-6 |
0.598 |
|
| 2003 |
Arnoult D, Karbowski M, Youle RJ. Caspase inhibition prevents the mitochondrial release of apoptosis-inducing factor. Cell Death and Differentiation. 10: 845-9. PMID 12815467 DOI: 10.1038/Sj.Cdd.4401240 |
0.646 |
|
| 2003 |
Santetl A, Frank S, Gaume B, Herrler M, Youle RJ, Fuller MT. Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells Journal of Cell Science. 116: 2763-2774. PMID 12759376 DOI: 10.1242/Jcs.00479 |
0.685 |
|
| 2003 |
Frank S, Robert EG, Youle RJ. Scission, spores, and apoptosis: a proposal for the evolutionary origin of mitochondria in cell death induction. Biochemical and Biophysical Research Communications. 304: 481-6. PMID 12729582 DOI: 10.1016/S0006-291X(03)00620-X |
0.657 |
|
| 2003 |
Smaili SS, Hsu YT, Carvalho AC, Rosenstock TR, Sharpe JC, Youle RJ. Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Mã©Dicas E Biolã³Gicas / Sociedade Brasileira De BiofãSica ... [Et Al.]. 36: 183-90. PMID 12563519 DOI: 10.1590/S0100-879X2003000200004 |
0.63 |
|
| 2002 |
Karbowski M, Lee YJ, Gaume B, Jeong SY, Frank S, Nechushtan A, Santel A, Fuller M, Smith CL, Youle RJ. Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis Journal of Cell Biology. 159: 931-938. PMID 12499352 DOI: 10.1083/Jcb.200209124 |
0.695 |
|
| 2002 |
De Giorgi F, Lartigue L, Bauer MKA, Schubert A, Grimm S, Hanson GT, Remington SJ, Youle RJ, Ichas F. The permeability transition pore signals apoptosis by directing Bax translocation and multimerization. The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 607-609. PMID 11919169 DOI: 10.1096/Fj.01-0269Fje |
0.65 |
|
| 2002 |
Ichinose M, Liu XH, Hagihara N, Youle RJ. Extracellular Bad fused to toxin transport domains induces apoptosis. Cancer Research. 62: 1433-8. PMID 11888916 |
0.56 |
|
| 2002 |
Saxena SK, Sirdeshmukh R, Ardelt W, Mikulski SM, Shogen K, Youle RJ. Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family. The Journal of Biological Chemistry. 277: 15142-6. PMID 11839736 DOI: 10.1074/jbc.M108115200 |
0.533 |
|
| 2001 |
Frank S, Gaume B, Bergmann-Leitner ES, Leitner WW, Robert EG, Catez F, Smith CL, Youle RJ. The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis. Developmental Cell. 1: 515-25. PMID 11703942 DOI: 10.1016/S1534-5807(01)00055-7 |
0.717 |
|
| 2001 |
Liu XH, Collier RJ, Youle RJ. Inhibition of axotomy-induced neuronal apoptosis by extracellular delivery of a Bcl-XL fusion protein. The Journal of Biological Chemistry. 276: 46326-32. PMID 11574549 DOI: 10.1074/Jbc.M108930200 |
0.619 |
|
| 2001 |
Smaili SS, Hsu YT, Sanders KM, Russell JT, Youle RJ. Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential. Cell Death and Differentiation. 8: 909-20. PMID 11526446 DOI: 10.1038/sj.cdd.4400889 |
0.65 |
|
| 2001 |
Nechushtan A, Smith CL, Lamensdorf I, Yoon SH, Youle RJ. Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis. The Journal of Cell Biology. 153: 1265-76. PMID 11402069 DOI: 10.1083/Jcb.153.6.1265 |
0.667 |
|
| 2001 |
Richter BW, Mir SS, Eiben LJ, Lewis J, Reffey SB, Frattini A, Tian L, Frank S, Youle RJ, Nelson DL, Notarangelo LD, Vezzoni P, Fearnhead HO, Duckett CS. Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. Molecular and Cellular Biology. 21: 4292-301. PMID 11390657 DOI: 10.1128/Mcb.21.13.4292-4301.2001 |
0.612 |
|
| 2001 |
Leonidas DD, Boix E, Prill R, Suzuki M, Turton R, Minson K, Swaminathan GJ, Youle RJ, Acharya KR. Mapping the ribonucleolytic active site of eosinophil-derived neurotoxin (EDN). High resolution crystal structures of EDN complexes with adenylic nucleotide inhibitors. The Journal of Biological Chemistry. 276: 15009-17. PMID 11154698 DOI: 10.1074/Jbc.M010585200 |
0.534 |
|
| 2000 |
Smaili SS, Hsu YT, Youle RJ, Russell JT. Mitochondria in Ca2+ signaling and apoptosis. Journal of Bioenergetics and Biomembranes. 32: 35-46. PMID 11768760 DOI: 10.1023/A:1005508311495 |
0.604 |
|
| 2000 |
Suzuki M, Youle RJ, Tjandra N. Structure of bax: Coregulation of dimer formation and intracellular localization Cell. 103: 645-654. PMID 11106734 DOI: 10.1016/S0092-8674(00)00167-7 |
0.612 |
|
| 2000 |
Ghatan S, Larner S, Kinoshita Y, Hetman M, Patel L, Xia Z, Youle RJ, Morrison RS. p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons. The Journal of Cell Biology. 150: 335-47. PMID 10908576 DOI: 10.1083/Jcb.150.2.335 |
0.577 |
|
| 1999 |
Liu XH, Castelli JC, Youle RJ. Receptor-mediated uptake of an extracellular Bcl-x(L) fusion protein inhibits apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 9563-7. PMID 10449732 DOI: 10.1073/pnas.96.17.9563 |
0.536 |
|
| 1999 |
Vasandani VM, Castelli JC, Hott JS, Saxena S, Mikulski SM, Youle RJ. Interferon enhances the activity of the anticancer ribonuclease, onconase. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 19: 447-54. PMID 10386856 DOI: 10.1089/107999099313884 |
0.513 |
|
| 1999 |
Basañez G, Nechushtan A, Drozhinin O, Chanturiya A, Choe E, Tutt S, Wood KA, Hsu Y, Zimmerberg J, Youle RJ. Bax, but not Bcl-xL, decreases the lifetime of planar phospholipid bilayer membranes at subnanomolar concentrations. Proceedings of the National Academy of Sciences of the United States of America. 96: 5492-7. PMID 10318911 DOI: 10.1073/Pnas.96.10.5492 |
0.624 |
|
| 1999 |
Nechushtan A, Smith CL, Hsu YT, Youle RJ. Conformation of the Bax C-terminus regulates subcellular location and cell death. The Embo Journal. 18: 2330-41. PMID 10228148 DOI: 10.1093/Emboj/18.9.2330 |
0.648 |
|
| 1999 |
Suzuki M, Saxena SK, Boix E, Prill RJ, Vasandani VM, Ladner JE, Sung C, Youle RJ. Engineering receptor-mediated cytotoxicity into human ribonucleases by steric blockade of inhibitor interaction. Nature Biotechnology. 17: 265-70. PMID 10096294 DOI: 10.1038/7010 |
0.558 |
|
| 1998 |
Castelli JC, Hassel BA, Maran A, Paranjape J, Hewitt JA, Li XL, Hsu YT, Silverman RH, Youle RJ. The role of 2'-5' oligoadenylate-activated ribonuclease L in apoptosis. Cell Death and Differentiation. 5: 313-20. PMID 10200477 DOI: 10.1038/Sj.Cdd.4400352 |
0.583 |
|
| 1998 |
Castelli J, Wood KA, Youle RJ. The 2-5A system in viral infection and apoptosis. Biomedicine & Pharmacotherapy = BioméDecine & PharmacothéRapie. 52: 386-90. PMID 9856285 DOI: 10.1016/S0753-3322(99)80006-7 |
0.525 |
|
| 1998 |
Oldfield EH, Youle RJ. Immunotoxins for brain tumor therapy. Current Topics in Microbiology and Immunology. 234: 97-114. PMID 9670615 DOI: 10.1007/978-3-642-72153-3_7 |
0.404 |
|
| 1998 |
Hsu YT, Youle RJ. Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. The Journal of Biological Chemistry. 273: 10777-83. PMID 9553144 DOI: 10.1074/Jbc.273.17.10777 |
0.618 |
|
| 1998 |
Hott JS, Dalakas MC, Sung C, Hallett M, Youle RJ. Skeletal muscle-specific immunotoxin for the treatment of focal muscle spasm. Neurology. 50: 485-91. PMID 9484377 DOI: 10.1212/Wnl.50.2.485 |
0.492 |
|
| 1998 |
Laske DW, Youle RJ, Oldfield EH. Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors. Nature Medicine. 3: 1362-8. PMID 9396606 DOI: 10.1038/Nm1297-1362 |
0.493 |
|
| 1997 |
Wolter KG, Hsu YT, Smith CL, Nechushtan A, Xi XG, Youle RJ. Movement of Bax from the cytosol to mitochondria during apoptosis. The Journal of Cell Biology. 139: 1281-92. PMID 9382873 DOI: 10.1083/jcb.139.5.1281 |
0.611 |
|
| 1997 |
Laske DW, Muraszko KM, Oldfield EH, DeVroom HL, Sung C, Dedrick RL, Simon TR, Colandrea J, Copeland C, Katz D, Greenfield L, Groves ES, Houston LL, Youle RJ. Intraventricular immunotoxin therapy for leptomeningeal neoplasia. Neurosurgery. 41: 1039-49; discussion . PMID 9361057 DOI: 10.1097/00006123-199711000-00005 |
0.498 |
|
| 1997 |
Castelli JC, Hassel BA, Wood KA, Li XL, Amemiya K, Dalakas MC, Torrence PF, Youle RJ. A study of the interferon antiviral mechanism: apoptosis activation by the 2-5A system. The Journal of Experimental Medicine. 186: 967-72. PMID 9294150 DOI: 10.1084/Jem.186.6.967 |
0.555 |
|
| 1997 |
Hsu YT, Youle RJ. Nonionic detergents induce dimerization among members of the Bcl-2 family. The Journal of Biological Chemistry. 272: 13829-34. PMID 9153240 DOI: 10.1074/Jbc.272.21.13829 |
0.606 |
|
| 1997 |
Hsu YT, Wolter KG, Youle RJ. Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 3668-72. PMID 9108035 DOI: 10.1073/Pnas.94.8.3668 |
0.612 |
|
| 1996 |
Mosimann SC, Newton DL, Youle RJ, James MN. X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution. Journal of Molecular Biology. 260: 540-52. PMID 8759319 DOI: 10.1006/Jmbi.1996.0420 |
0.505 |
|
| 1996 |
Youle RJ. Immunotoxins for central nervous system malignancy. Seminars in Cancer Biology. 7: 65-70. PMID 8740561 DOI: 10.1006/Scbi.1996.0010 |
0.511 |
|
| 1996 |
Saxena SK, Gravell M, Wu YN, Mikulski SM, Shogen K, Ardelt W, Youle RJ. Inhibition of HIV-1 production and selective degradation of viral RNA by an amphibian ribonuclease. The Journal of Biological Chemistry. 271: 20783-8. PMID 8702832 DOI: 10.1074/Jbc.271.34.20783 |
0.514 |
|
| 1996 |
Boix E, Wu Y, Vasandani VM, Saxena SK, Ardelt W, Ladner J, Youle RJ. Role of the N terminus in RNase A homologues: differences in catalytic activity, ribonuclease inhibitor interaction and cytotoxicity. Journal of Molecular Biology. 257: 992-1007. PMID 8632481 DOI: 10.1006/Jmbi.1996.0218 |
0.534 |
|
| 1995 |
Wu Y, Saxena SK, Ardelt W, Gadina M, Mikulski SM, De Lorenzo C, D'Alessio G, Youle RJ. A study of the intracellular routing of cytotoxic ribonucleases. The Journal of Biological Chemistry. 270: 17476-81. PMID 7542240 DOI: 10.1074/Jbc.270.29.17476 |
0.53 |
|
| 1995 |
Wood K, Youle R. The role of free radicals and p53 in neuron apoptosis in vivo The Journal of Neuroscience. 15: 5851-5857. DOI: 10.1523/Jneurosci.15-08-05851.1995 |
0.586 |
|
| 1994 |
Wu YN, Gadina M, Tao-Cheng JH, Youle RJ. Retinoic acid disrupts the Golgi apparatus and increases the cytosolic routing of specific protein toxins. The Journal of Cell Biology. 125: 743-53. PMID 8188744 DOI: 10.1083/Jcb.125.4.743 |
0.532 |
|
| 1994 |
Laske DW, Ilercil O, Akbasak A, Youle RJ, Oldfield EH. Efficacy of direct intratumoral therapy with targeted protein toxins for solid human gliomas in nude mice. Journal of Neurosurgery. 80: 520-6. PMID 8113865 DOI: 10.3171/Jns.1994.80.3.0520 |
0.508 |
|
| 1994 |
Ilercil O, Laske DW, Walbridge S, Muaszko K, Oldfield EH, Youle RJ. Neurotoxicity of immunotoxins. Molecular and Chemical Neuropathology. 21: 379-86. PMID 8086044 DOI: 10.1007/Bf02815363 |
0.491 |
|
| 1994 |
Youle RJ, Wu YN, Mikulski SM, Shogen K, Hamilton RS, Newton D, D'Alessio G, Gravell M. RNase inhibition of human immunodeficiency virus infection of H9 cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 6012-6. PMID 8016107 DOI: 10.1073/Pnas.91.13.6012 |
0.526 |
|
| 1994 |
Lin JJ, Newton DL, Mikulski SM, Kung HF, Youle RJ, Rybak SM. Characterization of the mechanism of cellular and cell free protein synthesis inhibition by an anti-tumor ribonuclease. Biochemical and Biophysical Research Communications. 204: 156-62. PMID 7945354 DOI: 10.1006/Bbrc.1994.2439 |
0.561 |
|
| 1994 |
Wood KA, Youle RJ. Apoptosis and free radicals. Annals of the New York Academy of Sciences. 738: 400-7. PMID 7832448 DOI: 10.1111/J.1749-6632.1994.Tb21829.X |
0.574 |
|
| 1994 |
Rybak SM, Hoogenboom HR, Newton DL, Raus JC, Youle RJ. Rational immunotherapy with ribonuclease chimeras. An approach toward humanizing immunotoxins. Cell Biophysics. 21: 121-38. PMID 1285324 DOI: 10.1007/BF02789483 |
0.527 |
|
| 1994 |
Newton D, Walbridge S, Mikulski S, Ardelt W, Shogen K, Ackerman S, Rybak S, Youle R. Toxicity of an antitumor ribonuclease to Purkinje neurons The Journal of Neuroscience. 14: 538-544. DOI: 10.1523/Jneurosci.14-02-00538.1994 |
0.551 |
|
| 1993 |
Wood KA, Dipasquale B, Youle RJ. In situ labeling of granule cells for apoptosis-associated DNA fragmentation reveals different mechanisms of cell loss in developing cerebellum. Neuron. 11: 621-32. PMID 8398151 DOI: 10.1016/0896-6273(93)90074-2 |
0.565 |
|
| 1992 |
Dipasquale B, Marini AM, Youle RJ. Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochemical and Biophysical Research Communications. 181: 1442-8. PMID 1764096 DOI: 10.1016/0006-291X(91)92101-O |
0.581 |
|
| 1992 |
Rybak SM, Hoogenboom HR, Meade HM, Raus JC, Schwartz D, Youle RJ. Humanization of immunotoxins. Proceedings of the National Academy of Sciences of the United States of America. 89: 3165-9. PMID 1565609 DOI: 10.1073/Pnas.89.8.3165 |
0.553 |
|
| 1992 |
Ilercil O, Laske D, Newton D, Rybak S, Oldfield E, Youle R. In Vitro and In Vivo Efficacy of a New Immunotoxin, 5E9-RNAse, in the Treatment of Human Gliomas Neurosurgery. 30: 804-805. DOI: 10.1097/00006123-199205000-00042 |
0.495 |
|
| 1990 |
Youle RJ. Toxin selection and modification--overview. Cancer Treatment and Research. 37: 93-6. PMID 2908644 DOI: 10.1007/978-1-4613-1083-9_6 |
0.435 |
|
| 1990 |
Youle RJ, Greenfield L, Johnson VG. Genetic engineering of immunotoxins. Cancer Treatment and Research. 37: 113-22. PMID 2908621 DOI: 10.1007/978-1-4613-1083-9_8 |
0.401 |
|
| 1990 |
Bridges S, Longo DL, Youle RJ. Preparation and use of anti-idiotypic antibodies armed with holotoxins or hemitoxins in treatment of B-cell neoplasms. Methods in Enzymology. 178: 356-68. PMID 2601625 DOI: 10.1016/0076-6879(89)78026-5 |
0.43 |
|
| 1990 |
Riedel CJ, Muraszko KM, Youle RJ. Diphtheria toxin mutant selectively kills cerebellar Purkinje neurons Proceedings of the National Academy of Sciences of the United States of America. 87: 5051-5055. PMID 2367523 DOI: 10.1073/Pnas.87.13.5051 |
0.558 |
|
| 1990 |
Hall WA, Merrill MJ, Walbridge S, Youle RJ. Epidermal growth factor receptors on ependymomas and other brain tumors. Journal of Neurosurgery. 72: 641-6. PMID 2319323 DOI: 10.3171/Jns.1990.72.4.0641 |
0.514 |
|
| 1990 |
Wrobel CJ, Wright DC, Dedrick RL, Youle RJ. Diphtheria toxin effects on brain-tumor xenografts. Implications for protein-based brain-tumor chemotherapy. Journal of Neurosurgery. 72: 946-50. PMID 2159988 DOI: 10.3171/Jns.1990.72.6.0946 |
0.501 |
|
| 1989 |
Johnson VG, Wrobel C, Wilson D, Zovickian J, Greenfield L, Oldfield EH, Youle R. Improved tumor-specific immunotoxins in the treatment of CNS and leptomeningeal neoplasia. Journal of Neurosurgery. 70: 240-8. PMID 2783608 DOI: 10.3171/Jns.1989.70.2.0240 |
0.509 |
|
| 1988 |
Boltansky H, Slater J, Youle R, Isersky C, Kaliner M. IgE-immunotoxins. II. IgE-ricin A-chain. Immunopharmacology. 14: 47-62. PMID 3500150 DOI: 10.1016/0162-3109(87)90008-7 |
0.53 |
|
| 1988 |
Youle RJ. Fatal attraction in vitro and in vivo. Journal of the National Cancer Institute. 80: 388-9. PMID 3259264 DOI: 10.1093/Jnci/80.6.388 |
0.504 |
|
| 1988 |
Zovickian J, Youle RJ. Efficacy of intrathecal immunotoxin therapy in an animal model of leptomeningeal neoplasia. Journal of Neurosurgery. 68: 767-74. PMID 3258632 DOI: 10.3171/jns.1988.68.5.0767 |
0.468 |
|
| 1987 |
Greenfield L, Johnson VG, Youle RJ. Mutations in diphtheria toxin separate binding from entry and amplify immunotoxin selectivity. Science (New York, N.Y.). 238: 536-9. PMID 3498987 DOI: 10.1126/Science.3498987 |
0.571 |
|
| 1987 |
Filipovich AH, Vallera DA, Youle RJ, Haake R, Blazar BR, Arthur D, Neville DM, Ramsay NK, McGlave P, Kersey JH. Graft-versus-host disease prevention in allogeneic bone marrow transplantation from histocompatible siblings. A pilot study using immunotoxins for T cell depletion of donor bone marrow. Transplantation. 44: 62-9. PMID 3299923 DOI: 10.1097/00007890-198707000-00015 |
0.613 |
|
| 1987 |
Zovickian J, Johnson VG, Youle RJ. Potent and specific killing of human malignant brain tumor cells by an anti-transferrin receptor antibody-ricin immunotoxin. Journal of Neurosurgery. 66: 850-61. PMID 3033171 DOI: 10.3171/jns.1987.66.6.0850 |
0.496 |
|
| 1984 |
Quinones RR, Youle RJ, Kersey JH, Zanjani ED, Azemove SM, Soderling CC, Lebien TW, Beverley PC, Neville DM, Vallera DA. Anti-T cell monoclonal antibodies conjugated to ricin as potential reagents for human GVHD prophylaxis: effect on the generation of cytotoxic T cells in both peripheral blood and bone marrow. Journal of Immunology (Baltimore, Md. : 1950). 132: 678-83. PMID 6606676 |
0.492 |
|
| 1984 |
Filipovich AH, Vallera DA, Youle RJ, Quinones RR, Neville DM, Kersey JH. Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease. Lancet (London, England). 1: 469-72. PMID 6142206 DOI: 10.1016/S0140-6736(84)92847-2 |
0.611 |
|
| 1984 |
Vallera DA, Kersey JH, Neville DM, Youle RJ. Use of Monoclonal Antibody-Intact Ricin Conjugates in Experimental Allogeneic Bone Marrow Transplantation Protides of the Biological Fluids. 31: 769-774. DOI: 10.1016/B978-0-08-030764-0.50175-0 |
0.524 |
|
| 1983 |
Vallera DA, Ash RC, Zanjani ED, Kersey JH, Lebien TW, Beverley PCL, Neville DM, Youle RJ. Anti-T-Cell reagents for human bone marrow transplantation: Ricin linked to three monoclonal antibodies Science. 222: 512-515. PMID 6353579 DOI: 10.1126/Science.6353579 |
0.656 |
|
| 1983 |
Vallera DA, Youle RJ, Neville DM, Soderling CCB, Kersey JH. Monoclonal antibody toxin conjugates for experimental graft-versus-host disease prophylaxis: Reagents selectively reactive with t cells and not murine stem cells Transplantation. 36: 73-80. PMID 6346616 DOI: 10.1097/00007890-198307000-00015 |
0.638 |
|
| 1982 |
Neville DM, Youle RJ. Monoclonal antibody-ricin or ricin A chain hybrids: kinetic analysis of cell killing for tumor therapy. Immunological Reviews. 62: 75-91. PMID 7042541 DOI: 10.1111/J.1600-065X.1982.Tb00390.X |
0.644 |
|
| 1982 |
Vallera DA, Youle RJ, Neville DM, Kersey JH. Bone marrow transplantation across major histocompatibility barriers. V. Protection of mice from lethal graft-vs.-host disease by pretreatment of donor cells with monoclonal anti-Thy-1.2 coupled to the toxin ricin Journal of Experimental Medicine. 155: 949-954. PMID 6120991 DOI: 10.1084/jem.155.3.949 |
0.632 |
|
| 1982 |
Youle RJ, Neville DM. Kinetics of protein synthesis inactivation by ricin-anti-Thy 1.1 monoclonal antibody hybrids. Role of the ricin B subunit demonstrated by reconstitution. The Journal of Biological Chemistry. 257: 1598-601. PMID 6120167 |
0.486 |
|
| 1981 |
Youle RJ, Murray GJ, Neville DM. Studies on the galactose-binding site of ricin and the hybrid toxin man6P-ricin Cell. 23: 551-559. PMID 7471212 DOI: 10.1016/0092-8674(81)90151-3 |
0.667 |
|
| 1981 |
Youle RJ, Neville DM. Anti-Thy 1.2 monoclonal antibody linked to ricin is a potent cell-type-specific toxin. Proceedings of the National Academy of Sciences of the United States of America. 77: 5483-6. PMID 6968914 DOI: 10.1073/Pnas.77.9.5483 |
0.677 |
|
| 1981 |
Robbins AR, Myerowitz R, Youle RJ, Murray GJ, Neville DM. The mannose 6-phosphate receptor of Chinese hamster ovary cells. Isolation of mutants with altered receptors Journal of Biological Chemistry. 256: 10618-10622. PMID 6270122 |
0.501 |
|
| 1980 |
Neville DM, Murray GJ, Youle RJ. Directed entry of hybrid proteins into cells via alternative receptors Biochemical Society Transactions. 8: 692-693. PMID 7461253 DOI: 10.1042/Bst0080692 |
0.67 |
|
| 1979 |
Youle RJ, Neville DM. Receptor-mediated transport of the hybrid protein ricin-diphtheria toxin fragment A with subsequent ADP-ribosylation of intracellular elongation factor II. The Journal of Biological Chemistry. 254: 11089-96. PMID 500625 |
0.54 |
|
| 1979 |
Youle RJ, Murray GJ, Neville DM. Ricin linked to monophosphopentamannose binds to fibroblast lysosomal hydrolase receptors, resulting in a cell-type-specific toxin Proceedings of the National Academy of Sciences of the United States of America. 76: 5559-5562. PMID 293662 DOI: 10.1073/Pnas.76.11.5559 |
0.677 |
|
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