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Nicole A. Horenstein, Ph.D. - Publications

Affiliations: 
Chemistry University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Organic Chemistry, Enzymology, Bioorganic Chemistry
Website:
https://www.chem.ufl.edu/people/name/nicole-horenstein/
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Stokes C, Pino JA, Hagan DW, Torres GE, Phelps EA, Horenstein NA, Papke RL. Betel quid: New insights into an ancient addiction. Addiction Biology. 27: e13223. PMID 36001424 DOI: 10.1111/adb.13223  0.307
2022 Papke RL, Karaffa M, Horenstein NA, Stokes C. Coffee and cigarettes: Modulation of high and low sensitivity α4β2 nicotinic acetylcholine receptors by n-MP, a biomarker of coffee consumption. Neuropharmacology. 216: 109173. PMID 35772522 DOI: 10.1016/j.neuropharm.2022.109173  0.329
2022 Papke RL, Andleeb H, Stokes C, Quadri M, Horenstein NA. Selective Agonists and Antagonists of α9 Versus α7 Nicotinic Acetylcholine Receptors. Acs Chemical Neuroscience. PMID 35167270 DOI: 10.1021/acschemneuro.1c00747  0.319
2021 Horenstein NA, Stokes C, Papke RL. Sulfonium Ligands of the α7 nAChR. Molecules (Basel, Switzerland). 26. PMID 34577114 DOI: 10.3390/molecules26185643  0.384
2021 Papke RL, Horenstein NA. Therapeutic Targeting of 7 Nicotinic Acetylcholine Receptors. Pharmacological Reviews. 73: 1118-1149. PMID 34301823 DOI: 10.1124/pharmrev.120.000097  0.375
2021 Pismataro MC, Horenstein NA, Stokes C, Dallanoce C, Thakur GA, Papke RL. Stable desensitization of α nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site. European Journal of Pharmacology. 905: 174179. PMID 34004208 DOI: 10.1016/j.ejphar.2021.174179  0.398
2020 Gulsevin A, Meiler J, Horenstein NA. A Computational Analysis of the Factors Governing the Dynamics of α7 nAChR and Its Homologs. Biophysical Journal. PMID 33010233 DOI: 10.1016/j.bpj.2020.09.006  0.759
2020 Pismataro MC, Horenstein NA, Stokes C, Quadri M, De Amici M, Papke RL, Dallanoce C. Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation. European Journal of Medicinal Chemistry. 205: 112669. PMID 32810771 DOI: 10.1016/J.Ejmech.2020.112669  0.492
2020 Papke RL, Garai S, Stokes C, Horenstein NA, Zimmerman AD, Abboud KA, Thakur GA. Differing activity profiles of the stereoisomers of 2,3,5,6TMP-TQS, a putative silent allosteric modulator of α7nAChR. Molecular Pharmacology. PMID 32690627 DOI: 10.1124/Mol.120.119958  0.509
2020 Gulsevin A, Papke RL, Horenstein N. In silico modeling of the α7 nicotinic acetylcholine receptor: new pharmacological challenges associated with multiple modes of signaling. Mini Reviews in Medicinal Chemistry. PMID 32000651 DOI: 10.2174/1389557520666200130105256  0.776
2019 Godin JR, Roy P, Quadri M, Bagdas D, Toma W, Narendrula-Kotha R, Kishta OA, Damaj MI, Horenstein NA, Papke RL, Simard AR. A silent agonist of α7 nicotinic acetylcholine receptors modulates inflammation ex vivo and attenuates EAE. Brain, Behavior, and Immunity. PMID 31874200 DOI: 10.1016/J.Bbi.2019.12.014  0.442
2019 Nuñez C, Horenstein NA. Functional Analysis of a Gene Cluster from Involved in Biosynthesis of the Pyrrolidine Azasugar DAB-1. Journal of Natural Products. PMID 31793783 DOI: 10.1021/Acs.Jnatprod.9B00758  0.707
2019 Stokes C, Garai S, Kulkarni AR, Cantwell LN, Noviello CM, Hibbs RE, Horenstein NA, Abboud KA, Thakur GA, Papke RL. Heteromeric neuronal nicotinic acetylcholine receptors with mutant beta subunits acquire sensitivity to α7-selective positive allosteric modulators. The Journal of Pharmacology and Experimental Therapeutics. PMID 31175218 DOI: 10.1124/Jpet.119.259499  0.33
2019 Gulsevin A, Papke RL, Stokes C, Thakur GA, Quadri M, Horenstein N. Allosteric agonism of α7 nicotinic acetylcholine receptors. Molecular Pharmacology. PMID 30944209 DOI: 10.1124/Mol.119.115758  0.792
2018 Quadri M, Garai S, Thakur GA, Stokes C, Gulsevin A, Horenstein NA, Papke RL. Macroscopic and microscopic activation of α7 nicotinic acetylcholine receptors by the structurally unrelated ago-PAMs B-973B and GAT107. Molecular Pharmacology. PMID 30348894 DOI: 10.1124/Mol.118.113340  0.765
2018 Quadri M, Silnović A, Matera C, Horenstein NA, Stokes C, De Amici M, Papke RL, Dallanoce C. Novel 5-(quinuclidin-3-ylmethyl)-1,2,4-oxadiazoles to investigate the activation of the α7 nicotinic acetylcholine receptor subtype: Synthesis and electrophysiological evaluation. European Journal of Medicinal Chemistry. 160: 207-228. PMID 30342362 DOI: 10.1016/J.Ejmech.2018.10.015  0.461
2018 Quadri M, Bagdas D, Toma W, Stokes C, Horenstein NA, Damaj MI, Papke RL. The antinociceptive and anti-inflammatory properties of the α7 nAChR weak partial agonist -CF-diethyl--phenylpiperazine. The Journal of Pharmacology and Experimental Therapeutics. PMID 30111636 DOI: 10.1124/Jpet.118.249904  0.399
2018 Arciola JM, Horenstein NA. Characterization of the PLP-dependent Transaminase Initiating Azasugar Biosynthesis. The Biochemical Journal. PMID 29907615 DOI: 10.1042/Bcj20180340  0.724
2017 Horenstein NA, Quadri M, Stokes C, Shoaib M, Papke RL. Cracking the Betel Nut: Cholinergic Activity of Areca Alkaloids and Related Compounds. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. PMID 29059390 DOI: 10.1093/Ntr/Ntx187  0.334
2017 Horenstein NA, Papke RL. Anti-inflammatory Silent Agonists. Acs Medicinal Chemistry Letters. 8: 989-991. PMID 29057037 DOI: 10.1021/Acsmedchemlett.7B00368  0.453
2017 Quadri M, Stokes C, Gulsevin A, Felts ACJ, Abboud KA, Papke RL, Horenstein NA. Sulfonium as a surrogate for Ammonium: A new α7 nicotinic acetylcholine receptor partial agonist with desensitizing activity. Journal of Medicinal Chemistry. PMID 28885019 DOI: 10.1021/Acs.Jmedchem.7B00875  0.788
2017 Dallanoce CML, Quadri M, Matera C, Silnović A, Pismataro MC, Horenstein NA, Stokes C, Papke RL. Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists based on the Spirocyclic Quinuclidine-Δ2-Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation. Chemmedchem. PMID 28494140 DOI: 10.1002/Cmdc.201700162  0.517
2017 Papke RL, Stokes C, Damaj MI, Thakur GA, Manther K, Treinin M, Bagdas D, Kulkarni AR, Horenstein NA. Persistent activation of α7 nAChRs associated with stable induction of different desensitized states. British Journal of Pharmacology. PMID 28477386 DOI: 10.1111/Bph.13851  0.446
2017 Quadri M, Matera C, Silnović A, Pismataro MC, Horenstein NA, Stokes C, Papke RL, Dallanoce C. Back Cover: Identification of α7 Nicotinic Acetylcholine Receptor Silent Agonists Based on the Spirocyclic Quinuclidine-Δ2 -Isoxazoline Scaffold: Synthesis and Electrophysiological Evaluation (ChemMedChem 16/2017) Chemmedchem. 12: 1417-1417. DOI: 10.1002/Cmdc.201700472  0.445
2016 Horenstein NA, Papke RL, Kulkarni AR, Chaturbhuj GU, Stokes C, Manther K, Thakur GA. Critical molecular determinants of α7 nicotinic acetylcholine receptor allosteric activation: separation of direct allosteric activation and positive allosteric modulation. The Journal of Biological Chemistry. PMID 26742843 DOI: 10.1074/Jbc.M115.692392  0.506
2015 Quadri M, Papke RL, Horenstein NA. Dissection of N,N-diethyl-N'-phenylpiperazines as α7 nicotinic receptor silent agonists. Bioorganic & Medicinal Chemistry. PMID 26707847 DOI: 10.1016/J.Bmc.2015.12.017  0.491
2015 Papke RL, Horenstein NA, Stokes C. Nicotinic Activity of Arecoline, the Psychoactive Element of "Betel Nuts", Suggests a Basis for Habitual Use and Anti-Inflammatory Activity. Plos One. 10: e0140907. PMID 26488401 DOI: 10.1371/Journal.Pone.0140907  0.412
2014 Papke RL, Chojnacka K, Horenstein NA. The minimal pharmacophore for silent agonism of the α7 nicotinic acetylcholine receptor. The Journal of Pharmacology and Experimental Therapeutics. 350: 665-80. PMID 24990939 DOI: 10.1124/Jpet.114.215236  0.764
2014 Papke RL, Horenstein NA, Kulkarni AR, Stokes C, Corrie LW, Maeng CY, Thakur GA. The activity of GAT107, an allosteric activator and positive modulator of α7 nicotinic acetylcholine receptors (nAChR), is regulated by aromatic amino acids that span the subunit interface. The Journal of Biological Chemistry. 289: 4515-31. PMID 24362025 DOI: 10.1074/Jbc.M113.524603  0.48
2014 Wu Y, Arciola J, Horenstein N. Medium-chain dehydrogenases with new specificity: Amino mannitol dehydrogenases on the azasugar biosynthetic pathway Protein and Peptide Letters. 21: 10-14. PMID 24354768 DOI: 10.2174/092986652101131219093413  0.701
2013 Chojnacka K, Papke RL, Horenstein NA. Synthesis and evaluation of a conditionally-silent agonist for the α7 nicotinic acetylcholine receptor. Bioorganic & Medicinal Chemistry Letters. 23: 4145-9. PMID 23746476 DOI: 10.1016/J.Bmcl.2013.05.039  0.772
2013 Isaacson MD, Horenstein NA, Stokes C, Kem WR, Papke RL. Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines. Biochemical Pharmacology. 85: 817-28. PMID 23352650 DOI: 10.1016/J.Bcp.2013.01.010  0.492
2012 Wang J, Papke RL, Stokes C, Horenstein NA. Potential state-selective hydrogen bond formation can modulate activation and desensitization of the α7 nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 287: 21957-69. PMID 22556416 DOI: 10.1074/Jbc.M112.339796  0.516
2011 Pierdominici-Sottile G, Horenstein NA, Roitberg AE. Free energy study of the catalytic mechanism of Trypanosoma cruzi trans-sialidase. From the Michaelis complex to the covalent intermediate. Biochemistry. 50: 10150-8. PMID 22007596 DOI: 10.1021/Bi2009618  0.304
2011 Clark LF, Johnson JV, Horenstein NA. Identification of a gene cluster that initiates Azasugar biosynthesis in Bacillus amyloliquefaciens Chembiochem. 12: 2147-2150. PMID 21786380 DOI: 10.1002/Cbic.201100347  0.569
2011 Williams DK, Stokes C, Horenstein NA, Papke RL. The effective opening of nicotinic acetylcholine receptors with single agonist binding sites. The Journal of General Physiology. 137: 369-84. PMID 21444659 DOI: 10.1085/Jgp.201010587  0.453
2011 Papke RL, Stokes C, Williams DK, Wang J, Horenstein NA. Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper. Neuropharmacology. 60: 159-71. PMID 20650284 DOI: 10.1016/J.Neuropharm.2010.07.014  0.581
2011 Papke RL, Williams DK, Wang J, Horenstein NA. Positive and negative cooperativity of agonist and allosteric modulator binding in alpha7 nAChR: Looking for the therapeutic window Biochemical Pharmacology. 82: 1031. DOI: 10.1016/J.Bcp.2011.07.024  0.528
2010 Wang J, Horenstein NA, Stokes C, Papke RL. Tethered agonist analogs as site-specific probes for domains of the human α7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization. Molecular Pharmacology. 78: 1012-25. PMID 20823218 DOI: 10.1124/Mol.110.066662  0.618
2010 Leonik FM, Ghiviriga I, Horenstein NA. Synthesis of 3, 5-diazabicyclo [5.1.0] octenes. A new platform to mimic glycosidase transition states Tetrahedron. 66: 5566-5572. DOI: 10.1016/J.Tet.2010.05.064  0.749
2009 Williams DK, Stokes C, Horenstein NA, Papke RL. Differential regulation of receptor activation and agonist selectivity by highly conserved tryptophans in the nicotinic acetylcholine receptor binding site. The Journal of Pharmacology and Experimental Therapeutics. 330: 40-53. PMID 19339660 DOI: 10.1124/Jpet.109.151225  0.44
2009 Papke RL, Kem WR, Soti F, López-Hernández GY, Horenstein NA. Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine. The Journal of Pharmacology and Experimental Therapeutics. 329: 791-807. PMID 19223664 DOI: 10.1124/Jpet.108.150151  0.493
2009 Wang J, Papke RL, Horenstein NA. Synthesis of H-bonding probes of alpha7 nAChR agonist selectivity. Bioorganic & Medicinal Chemistry Letters. 19: 474-6. PMID 19081250 DOI: 10.1016/J.Bmcl.2008.11.044  0.565
2008 Horenstein NA, Leonik FM, Papke RL. Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors. Molecular Pharmacology. 74: 1496-511. PMID 18768388 DOI: 10.1124/Mol.108.048892  0.778
2007 Leonik FM, Papke RL, Horenstein NA. Quinuclidines as selective agonists for alpha-7 nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. 17: 1520-2. PMID 17276680 DOI: 10.1016/J.Bmcl.2007.01.003  0.781
2007 Horenstein NA, McCormack TJ, Stokes C, Ren K, Papke RL. Reversal of agonist selectivity by mutations of conserved amino acids in the binding site of nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 282: 5899-909. PMID 17189260 DOI: 10.1074/Jbc.M609202200  0.479
2006 Papke RL, McCormack TJ, Stokes C, Horenstein NA. P4-399: Essential factors for the selective activation of nicotinic alpha7-type receptors, potential therapeutic targets for Alzheimer's disease Alzheimer's & Dementia. 2: S635-S635. DOI: 10.1016/J.Jalz.2006.05.2140  0.399
2005 Papke RL, Zheng G, Horenstein NA, Dwoskin LP, Crooks PA. The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion. Bioorganic & Medicinal Chemistry Letters. 15: 3874-80. PMID 16005216 DOI: 10.1016/J.Bmcl.2005.05.118  0.459
2005 Papke RL, Schiff HC, Jack BA, Horenstein NA. Molecular dissection of tropisetron, an alpha7 nicotinic acetylcholine receptor-selective partial agonist. Neuroscience Letters. 378: 140-4. PMID 15781147 DOI: 10.1016/J.Neulet.2004.12.025  0.485
2005 Papke RL, Buhr JD, Francis MM, Choi KI, Thinschmidt JS, Horenstein NA. The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate. Molecular Pharmacology. 67: 1977-90. PMID 15761116 DOI: 10.1124/Mol.105.011676  0.429
2005 Sun H, Abboud KA, Horenstein NA. A new route into hexahydro-cyclopenta[b]pyrrole-cis-3a,6-diols. Synthesis of constrained bicyclic analogues of pyrrolidine azasugars Tetrahedron. 61: 10462-10469. DOI: 10.1016/J.Tet.2005.08.055  0.319
2004 Stokes C, Papke JK, Horenstein NA, Kem WR, McCormack TJ, Papke RL. The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors. Molecular Pharmacology. 66: 14-24. PMID 15213292 DOI: 10.1124/Mol.66.1.14  0.397
2004 Papke RL, Meyer EM, Lavieri S, Bollampally SR, Papke TA, Horenstein NA, Itoh Y, Porter Papke JK. Effects at a distance in alpha 7 nAChR selective agonists: benzylidene substitutions that regulate potency and efficacy. Neuropharmacology. 46: 1023-38. PMID 15081799 DOI: 10.1016/J.Neuropharm.2004.01.005  0.45
2004 Young JEP, Horenstein NA. Synthesis of endo-(3-azabicyclo[3.1.0]hex-6-yl)-methanol and derivatives as new geometric/charge mimics of glycosyltransfer transition states Tetrahedron Letters. 45: 9505-9507. DOI: 10.1016/J.Tetlet.2004.10.156  0.318
2004 Burke EE, Horenstein NA. Enzymatic synthesis of [1-14C-N-acetyl, P18O 2] cytidine monophosphate neuraminic acid Journal of Labelled Compounds and Radiopharmaceuticals. 47: 1007-1017. DOI: 10.1002/Jlcr.889  0.597
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