Ikyon Kim, Ph.D. - Publications

Affiliations: 
Pharmacy Yonsei University, Seoul, South Korea 
Area:
Organic Chemistry

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Cha M, Dagar A, Lee S, Cho I, Lee D, Kim K, Park I, Yoon S, Kim HY, Kim I, Kim Y. Benzo[]imidazole-pyrrolo[1,2-]pyrazine Hybrids Ameliorate Amyloid Aggregates in the Brain of Alzheimer Transgenic Mice. Acs Chemical Neuroscience. PMID 37552840 DOI: 10.1021/acschemneuro.2c00547  0.398
2023 Nam S, Lee S, Kim W, Kim I. Divergent synthesis of two types of indolizines from pyridine-2-acetonitrile, (hetero)arylglyoxal, and TMSCN. Organic & Biomolecular Chemistry. PMID 37097478 DOI: 10.1039/d3ob00471f  0.517
2022 Lee HY, Yoon S, Lee JH, Park K, Jung Y, Cho I, Lee D, Shin J, Kim K, Kim S, Kim J, Kim K, Han SH, Kim SM, Kim HJ, ... ... Kim I, et al. Aryloxypropanolamine targets amyloid aggregates and reverses Alzheimer-like phenotypes in Alzheimer mouse models. Alzheimer's Research & Therapy. 14: 177. PMID 36443837 DOI: 10.1186/s13195-022-01112-6  0.651
2022 Lee Y, Joshi DR, Namkung W, Kim I. Generation of a poly-functionalized indolizine scaffold and its anticancer activity in pancreatic cancer cells. Bioorganic Chemistry. 126: 105877. PMID 35636126 DOI: 10.1016/j.bioorg.2022.105877  0.576
2021 Kim K, Lee JH, Kim S, Lee S, Lee D, Kim HY, Kim I, Kim Y. Anti-amyloidogenic indolizino[3,2-]quinolines as imaging probes differentiating dense-core, diffuse, and coronal plaques of amyloid-β. Rsc Medicinal Chemistry. 12: 1926-1934. PMID 34825188 DOI: 10.1039/d1md00030f  0.473
2021 Jung K, Kim S, Choi S, Kim I, Han G. Development of a DABCO-Succinic Acid Based Catalytic System for the Aza-Michael Addition and Aza-Michael/Knoevenagel Tandem Reaction of Thiazolidine-2,4-dione to Electron Deficient Alkenes. The Journal of Organic Chemistry. PMID 34757757 DOI: 10.1021/acs.joc.1c02003  0.535
2021 Lee S, Kim S, Yoon SH, Dagar A, Kim I. Diastereoselective Synthesis of Densely Functionalized 3a,8a-Dihydro-8-furo[3,2-]pyrrolizines through One-Pot Three-Component Assembly. The Journal of Organic Chemistry. 86: 12367-12377. PMID 34479403 DOI: 10.1021/acs.joc.1c01315  0.648
2021 Joshi DR, Kim I. Correction to "Michael-Aldol Double Elimination Cascade to Make Pyridines: Use of Chromone for the Synthesis of Indolizines". The Journal of Organic Chemistry. PMID 34436894 DOI: 10.1021/acs.joc.1c01980  0.629
2021 Joshi DR, Kim I. Michael-Aldol Double Elimination Cascade to Make Pyridines: Use of Chromone for the Synthesis of Indolizines. The Journal of Organic Chemistry. PMID 34292727 DOI: 10.1021/acs.joc.1c00981  0.657
2021 Kim S, Lee JH, Yoon SH, Kim I. A regioselective [4 + 2] annulation approach to 5-acylindolizine-7-carbonitriles: generation of poly-substituted pyridines. Organic & Biomolecular Chemistry. PMID 34113946 DOI: 10.1039/d1ob00788b  0.567
2020 Kim D, Bae GH, Kim HY, Jeon H, Kim K, Shin J, Lee S, Hong S, Kim I, Kim Y. Orally Administered Benzofuran Derivative Disaggregated Aβ Plaques and Oligomers in the Brain of 5XFAD Alzheimer Transgenic Mouse. Acs Chemical Neuroscience. PMID 33332107 DOI: 10.1021/acschemneuro.0c00606  0.404
2020 Dagar A, Kim I. Expansion of diazepine heterocyclic chemical space sequential Knoevenagel condensation-intramolecular aza-Wittig reaction: 2-acyl-4-aryl-5-pyrrolo[1,2-][1,4]diazepines. Organic & Biomolecular Chemistry. PMID 33289769 DOI: 10.1039/d0ob02002h  0.315
2020 Prasad SS, Joshi DR, Lee JH, Kim I. One-pot access to 2-amino-3-arylbenzofurans: direct entry to polyheterocyclic chemical space. Organic & Biomolecular Chemistry. PMID 33016294 DOI: 10.1039/d0ob01715a  0.642
2020 Joshi DR, Seo Y, Heo Y, Park SH, Lee Y, Namkung W, Kim I. Domino [4+2] Annulation Access to Quinone-Indolizine Hybrids: Anticancer N-Fused Polycycles. The Journal of Organic Chemistry. PMID 32674567 DOI: 10.1021/Acs.Joc.0C01291  0.658
2020 Seo Y, Choi J, Lee JH, Kim TG, Park SH, Han G, Namkung W, Kim I. Diversity-oriented generation and biological evaluation of new chemical scaffolds bearing a 2,2-dimethyl-2H-chromene unit: Discovery of novel potent ANO1 inhibitors. Bioorganic Chemistry. 101: 104000. PMID 32592976 DOI: 10.1016/J.Bioorg.2020.104000  0.304
2020 Dagar A, Seo Y, Namkung W, Kim I. A domino annulation approach to 3,4-diacylpyrrolo[1,2-a]pyrazines: decoration of pyrazine units. Organic & Biomolecular Chemistry. PMID 32293635 DOI: 10.1039/D0Ob00444H  0.415
2020 Dagar A, Joshi DR, Kim I. Solvent-Controlled Divergent Syntheses of Polycyclic N-Fused Heteroaromatics Synthesis. 52: 2841-2856. DOI: 10.1055/S-0040-1707865  0.644
2020 Bae GH, Kim S, Lee NK, Dagar A, Lee JH, Lee J, Kim I. Facile approach to benzo[d]imidazole-pyrrolo[1,2-a]pyrazine hybrid structures through double cyclodehydration and aromatization and their unique optical properties with blue emission Rsc Advances. 10: 7265-7288. DOI: 10.1039/D0Ra01140A  0.348
2020 Joshi D, Seo Y, Heo Y, Park S, Lee Y, Namkung W, Kim I. Domino [4 + 2] AnnulationAccess to Quinone–IndolizineHybrids: Anticancer N‑Fused Polycycles Journal of Organic Chemistry. DOI: 10.1021/Acs.Joc.0C01291.S001  0.366
2019 Seo Y, Lee JH, Park SH, Namkung W, Kim I. Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells. European Journal of Medicinal Chemistry. 188: 111988. PMID 31901746 DOI: 10.1016/J.Ejmech.2019.111988  0.31
2019 Dagar A, Bae GH, Lee JH, Kim I. Tandem [4+1+1] Annulation Approach to 4-Acyl-3,4-dihydropyrrolo[1,2-a]pyrazines: Diastereoselective Construction of Dihydropyrazine Units from Pyrroles. The Journal of Organic Chemistry. PMID 31090411 DOI: 10.1021/Acs.Joc.9B00724  0.399
2019 Neo Shin N, Jeon H, Jung Y, Baek S, Lee S, Yoo HC, Bae GH, Park K, Yang SH, Han JM, Kim I, Kim Y. Fluorescent 1,4-Naphthoquinones To Visualize Diffuse and Dense-Core Amyloid Plaques in APP/PS1 Transgenic Mouse Brains. Acs Chemical Neuroscience. PMID 31016960 DOI: 10.1021/Acschemneuro.9B00093  0.604
2019 Prasad SS, Singh DK, Kim I. One-Pot, Three-Component Approach to Diarylmethylphosphonates: A Direct Entry to Polycyclic Aromatic Systems. The Journal of Organic Chemistry. PMID 30990320 DOI: 10.1021/Acs.Joc.9B00668  0.375
2019 Kim J, Park M, Choi J, Singh DK, Kwon HJ, Kim SH, Kim I. Design, synthesis, and biological evaluation of novel pyrrolo[1,2-a]pyrazine derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 30954427 DOI: 10.1016/J.Bmcl.2019.03.044  0.357
2019 Singh DK, Jang K, Kim J, Lee J, Kim I. Intramolecular Electrophilic Cyclization Approach to 6-Substituted Naphtho[2,1-b]benzofurans: Novel Dual-State Emissive Fluorophores with Blue Emission. Acs Combinatorial Science. PMID 30925043 DOI: 10.1021/Acscombsci.9B00006  0.334
2019 Singh DK, Kim I. Electrophilic acetylation and formylation of pyrrolo[1,2-a]pyrazines: substituent effects on regioselectivity Arkivoc. 2019: 8-21. DOI: 10.24820/Ark.5550190.P010.807  0.335
2019 Singh DK, Prasad SS, Kim J, Kim I. One-pot, three-component approach to diarylacetonitriles Organic Chemistry Frontiers. 6: 669-673. DOI: 10.1039/C8Qo01419A  0.364
2019 Singh DK, Kim I. Convergent synthesis of diptoindonesin G Tetrahedron Letters. 60: 300-301. DOI: 10.1016/J.Tetlet.2018.12.036  0.371
2018 Kwon S, Lee Y, Jung Y, Kim JH, Baek B, Lim B, Lee J, Kim I, Lee J. Mitochondria-targeting indolizino[3,2-c]quinolines as novel class of photosensitizers for photodynamic anticancer activity. European Journal of Medicinal Chemistry. 148: 116-127. PMID 29454916 DOI: 10.1016/J.Ejmech.2018.02.016  0.631
2018 Singh DK, Kim I. Skeletal Reorganization: Synthesis of Diptoindonesin G from Pauciflorol F. The Journal of Organic Chemistry. PMID 29322777 DOI: 10.1021/Acs.Joc.7B03089  0.313
2017 Park S, Kim EH, Kim J, Kim SH, Kim I. Biological evaluation of indolizine-chalcone hybrids as new anticancer agents. European Journal of Medicinal Chemistry. 144: 435-443. PMID 29288944 DOI: 10.1016/J.Ejmech.2017.12.056  0.309
2017 Kim J, Kim I. Design and synthesis of a hybrid framework of indanone and chromane: total synthesis of a homoisoflavanoid, brazilane. Organic & Biomolecular Chemistry. 16: 89-100. PMID 29192699 DOI: 10.1039/C7Ob02758C  0.408
2017 Nayak M, Kang YK, Kim I. Altering the Cyclization Modes: Temperature-Dependent Intramolecular 7-Endo-Dig vs 6-Endo-Dig Electrophilic Ring Closures. Organic Letters. PMID 28271894 DOI: 10.1021/Acs.Orglett.7B00472  0.359
2017 Yoon S, Jung Y, Kim I. Catalyst-free synthesis of 4-alkynylazobenzenes from quinols Tetrahedron Letters. 58: 1590-1591. DOI: 10.1016/J.Tetlet.2017.03.027  0.375
2017 Kim J, Heo Y, Jung Y, Lee J, Kim I. Diversity-oriented functionalization of indolizines at the C3 position via multicomponent Kabachnik-Fields reaction Tetrahedron. 73: 5759-5768. DOI: 10.1016/J.Tet.2017.08.017  0.35
2017 Nayak M, Singh DK, Kim I. Polyaromatic heterocycles through intramolecular alkyne carbonyl metathesis: 5-Acylnaphtho[2,1- b ]benzofurans Tetrahedron. 73: 1831-1840. DOI: 10.1016/J.Tet.2017.02.036  0.368
2016 Jung Y, Singh DK, Kim I. Symmetry-based approach to oligostilbenoids: Rapid entry to viniferifuran, shoreaphenol, malibatol A, and diptoindonesin G. Beilstein Journal of Organic Chemistry. 12: 2689-2693. PMID 28144340 DOI: 10.3762/Bjoc.12.266  0.672
2016 Jung Y, Kim I. Chemoselective reduction of quinols as an alternative to Sonogashira coupling: synthesis of polysubstituted benzofurans. Organic & Biomolecular Chemistry. PMID 27759129 DOI: 10.1039/C6Ob01941B  0.673
2016 Nayak M, Jung Y, Kim I. Syntheses of pterocarpenes and coumestans via regioselective cyclodehydration. Organic & Biomolecular Chemistry. PMID 27503798 DOI: 10.1039/C6Ob01451H  0.669
2016 Kim I, Nayak M, Singh D. Regiospecific Synthesis of 5- and 6-Acylated Naphtho[1,2-b]benzofurans via Intramolecular Alkyne Carbonyl Metathesis Synthesis. 49: 2063-2073. DOI: 10.1055/S-0036-1588120  0.38
2016 Kim I, Singh D, Jung Y. Total Syntheses of Urgineanins A, B, D, and Their Analogues Synthesis. 49: 1531-1537. DOI: 10.1055/S-0036-1588105  0.357
2016 Jeong K, Choi B, Moon J, Hyun D, Lee J, Kim I, Kim G, Kang S. Establishment of the hazard reduction methodology to be taken into account for safety assessment during decommissioning of nuclear facilities Annals of Nuclear Energy. 87: 7-15. DOI: 10.1016/j.anucene.2015.08.008  0.305
2016 Jung Y, Kim I. Synthesis of 6-Aryl-5-iodobenzo[e]pyrido[1,2-a]indoles by 6-endo-dig Iodocyclization Asian Journal of Organic Chemistry. 5: 147-152. DOI: 10.1002/Ajoc.201500423  0.35
2015 Zhao Z, Wang L, James T, Jung Y, Kim I, Tan R, Hoffmann FM, Xu W. Reciprocal Regulation of ERα and ERβ Stability and Activity by Diptoindonesin G. Chemistry & Biology. PMID 26670079 DOI: 10.1016/J.Chembiol.2015.10.011  0.582
2015 Moon SH, Jung Y, Kim SH, Kim I. Synthesis, characterization and biological evaluation of anti-cancer indolizine derivatives via inhibiting β-catenin activity and activating p53. Bioorganic & Medicinal Chemistry Letters. PMID 26608553 DOI: 10.1016/J.Bmcl.2015.11.021  0.625
2015 Lee W, Seo J, Kwak S, Park EJ, Na DH, Kim S, Lee YM, Kim IS, Bae JS. A Double-Chambered Protein Nanocage Loaded with Thrombin Receptor Agonist Peptide (TRAP) and γ-Carboxyglutamic Acid of Protein C (PC-Gla) for Sepsis Treatment. Advanced Materials (Deerfield Beach, Fla.). PMID 26414883 DOI: 10.1002/adma.201503093  0.372
2015 Jung Y, Kim I. C3 functionalization of indolizines via In(iii)-catalyzed three-component reaction. Organic & Biomolecular Chemistry. PMID 26380932 DOI: 10.1039/C5Ob01657F  0.65
2015 Jung Y, Kim I. Deformylative Intramolecular Hydroarylation: Synthesis of Benzo[e]pyrido[1,2-a]indoles. Organic Letters. 17: 4600-3. PMID 26345614 DOI: 10.1021/Acs.Orglett.5B02331  0.654
2015 Nayak M, Kim I. Construction of benzo-fused indolizines, pyrrolo[1,2-a]quinolines via alkyne-carbonyl metathesis. Organic & Biomolecular Chemistry. PMID 26270234 DOI: 10.1039/C5Ob01383F  0.432
2015 Byeon JY, Kim YH, Na HS, Jang JH, Kim SH, Lee YJ, Bae JW, Kim IS, Jang CG, Chung MW, Lee SY. Effects of the CYP2D6*10 allele on the pharmacokinetics of atomoxetine and its metabolites. Archives of Pharmacal Research. PMID 26254792 DOI: 10.1007/s12272-015-0646-z  0.359
2015 Shin KO, Bae JY, Woo J, Jang KS, Kim KS, Park JS, Kim IK, Kang S. The effect of exercise on expression of myokine and angiogenesis mRNA in skeletal muscle of high fat diet induced obese rat. Journal of Exercise Nutrition & Biochemistry. 19: 91-8. PMID 26244127 DOI: 10.5717/jenb.2015.15061006  0.348
2015 Park S, Kwon DI, Lee J, Kim I. When Indolizine Meets Quinoline: Diversity-Oriented Synthesis of New Polyheterocycles and Their Optical Properties. Acs Combinatorial Science. 17: 459-69. PMID 26203781 DOI: 10.1021/Acscombsci.5B00031  0.374
2015 Seo D, Lee J, Kim SW, Kim I, Na J, Hong MH, Choi HJ. Structural modulation of silicon nanowires by combining a high gas flow rate with metal catalysts. Nanoscale Research Letters. 10: 190. PMID 26034411 DOI: 10.1186/s11671-015-0893-4  0.304
2015 Jung Y, Kim I. A concise synthetic approach to brazilin via Pd-catalyzed allylic arylation. Organic & Biomolecular Chemistry. 13: 4331-5. PMID 25767080 DOI: 10.1039/C5Ob00216H  0.666
2015 Baek JM, Kim JY, Jung Y, Moon SH, Choi MK, Kim SH, Lee MS, Kim I, Oh J. Mollugin from Rubea cordifolia suppresses receptor activator of nuclear factor-κB ligand-induced osteoclastogenesis and bone resorbing activity in vitro and prevents lipopolysaccharide-induced bone loss in vivo. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 22: 27-35. PMID 25636867 DOI: 10.1016/J.Phymed.2014.10.008  0.58
2015 Jung Y, Kim I. Total synthesis of brazilin. The Journal of Organic Chemistry. 80: 2001-5. PMID 25562504 DOI: 10.1021/Jo502745J  0.677
2015 Park S, Kim I. Electron-withdrawing group effect in aryl group of allyl bromides for the successful synthesis of indolizines via a novel [3+3] annulation approach Tetrahedron. 71: 1982-1991. DOI: 10.1016/J.Tet.2015.02.013  0.409
2014 Lee JH, Kim M, Kim I. Palladium-catalyzed α-arylation of aryloxyketones for the synthesis of 2,3-disubstituted benzofurans. The Journal of Organic Chemistry. 79: 6153-63. PMID 24856099 DOI: 10.1021/Jo500885W  0.37
2014 Park S, Jung Y, Kim I. Diversity-oriented decoration of pyrrolo[1,2-a]pyrazines Tetrahedron. 70: 7534-7550. DOI: 10.1016/J.Tet.2014.08.003  0.418
2013 Kim M, Jung Y, Kim I. Domino Knoevenagel condensation/intramolecular aldol cyclization route to diverse indolizines with densely functionalized pyridine units. The Journal of Organic Chemistry. 78: 10395-404. PMID 24067193 DOI: 10.1021/Jo401801J  0.68
2013 Lee JH, Kim I. Cycloaromatization approach to polysubstituted indolizines from 2-acetylpyrroles: decoration of the pyridine unit. The Journal of Organic Chemistry. 78: 1283-8. PMID 23289526 DOI: 10.1021/Jo302590A  0.391
2012 Jung Y, Kim I. Facile approach to diverse 3-acylated indolizines via a sequential Sonogashira coupling/iodocyclization process Tetrahedron. 68: 8198-8206. DOI: 10.1016/J.Tet.2012.07.068  0.346
2012 Cho H, Kim I. Palladium-catalyzed construction of poly-substituted indolizinones Tetrahedron. 68: 5464-5480. DOI: 10.1016/J.Tet.2012.04.091  0.406
2011 Mao G, Kraus GA, Kim I, Spurlock ME, Bailey TB, Beitz DC. Effect of a mitochondria-targeted vitamin E derivative on mitochondrial alteration and systemic oxidative stress in mice. The British Journal of Nutrition. 106: 87-95. PMID 21324214 DOI: 10.1017/S0007114510005830  0.37
2010 Mao G, Kraus GA, Kim I, Spurlock ME, Bailey TB, Zhang Q, Beitz DC. A mitochondria-targeted vitamin E derivative decreases hepatic oxidative stress and inhibits fat deposition in mice. The Journal of Nutrition. 140: 1425-31. PMID 20554905 DOI: 10.3945/Jn.110.121715  0.378
2009 Kim I, Choi J. A versatile approach to oligostilbenoid natural products--synthesis of permethylated analogues of viniferifuran, malibatol A, and shoreaphenol. Organic & Biomolecular Chemistry. 7: 2788-95. PMID 19532996 DOI: 10.1039/B901911A  0.411
2005 Keller VA, Kim I, Burke SD. Synthetic efforts toward the C22-C36 subunit of halichondrin B utilizing local and imposed symmetry. Organic Letters. 7: 737-40. PMID 15704938 DOI: 10.1021/Ol0473400  0.369
2004 Kraus GA, Kim I, Kesavan S. The reaction of 4-methoxybenzylmagnesium chloride with aldehydes. The formation of 4-exomethylenecyclohexenones Tetrahedron Letters. 45: 6839-6840. DOI: 10.1016/J.Tetlet.2004.07.117  0.623
2004 Kraus GA, Kim I. A Direct Route to Isoflavan Quinones. The Synthesis of Colutequinones A (Ia) and B (Ib). Cheminform. 35. DOI: 10.1002/chin.200405228  0.44
2003 Kraus GA, Kim I. A direct synthesis of O-methyl claussequinone. The Journal of Organic Chemistry. 68: 4517-8. PMID 12762759 DOI: 10.1021/jo030026j  0.416
2003 Kraus GA, Kim I. Synthetic approach to malibatol A. Organic Letters. 5: 1191-2. PMID 12688716 DOI: 10.1021/ol027574o  0.467
2003 Kraus GA, Kim I. A direct route to isoflavan quinones. The synthesis of colutequinones A and B Tetrahedron. 59: 7935-7937. DOI: 10.1016/J.Tet.2003.08.015  0.42
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