Irving W. Wainer - Publications

Affiliations: 
McGill University, Montreal, QC, Canada 
Area:
Analytical Chemistry, Pharmaceutical Chemistry

126 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Wnorowski A, Dudzik D, Bernier M, Wójcik J, Keijzers G, Diaz-Ruiz A, Mazur K, Zhang Y, Han H, Scheibye-Knudsen M, Jozwiak K, Barbas C, Wainer IW. Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β adrenergic agonist. Scientific Reports. 12: 3618. PMID 35256673 DOI: 10.1038/s41598-022-07600-x  0.783
2019 Woo AY, Ge XY, Pan L, Xing G, Mo YM, Xing RJ, Li XR, Zhang YY, Wainer IW, Cheng MS, Xiao RP. Discovery of β-arrestin-biased β-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives. Acta Pharmacologica Sinica. PMID 30643208 DOI: 10.1038/S41401-018-0200-X  0.357
2018 Faccio AT, Ruperez FJ, Singh NS, Angulo S, Tavares MFM, Bernier M, Barbas C, Wainer IW. Stereochemical and structural effects of (2R,6R)-hydroxynorketamine on the mitochondrial metabolome in PC-12 cells. Biochimica Et Biophysica Acta. PMID 29526507 DOI: 10.1016/J.Bbagen.2018.03.008  0.353
2017 Bernier M, Catazaro J, Singh NS, Wnorowski A, Boguszewska-Czubara A, Jozwiak K, Powers R, Wainer IW. GPR55 receptor antagonist decreases glycolytic activity in PANC-1 pancreatic cancer cell line and tumor xenografts. International Journal of Cancer. PMID 28741686 DOI: 10.1002/Ijc.30904  0.807
2017 Wnorowski A, Such J, Paul RK, Wersto RP, Indig FE, Jozwiak K, Bernier M, Wainer IW. Concurrent activation of β2-adrenergic receptor and blockage of GPR55 disrupts pro-oncogenic signaling in glioma cells. Cellular Signalling. PMID 28495590 DOI: 10.1016/J.Cellsig.2017.05.006  0.813
2016 Can A, Zanos P, Moaddel R, Kang HJ, Dossou KS, Wainer IW, Cheer JF, Frost DO, Huang XP, Gould TD. Effects of ketamine and ketamine metabolites on evoked striatal dopamine release, dopamine receptors, and monoamine transporters. The Journal of Pharmacology and Experimental Therapeutics. PMID 27469513 DOI: 10.1124/Jpet.116.235838  0.352
2016 Singh NS, Bernier M, Wainer IW. Selective GPR55 antagonism reduces chemoresistance in cancer cells. Pharmacological Research. PMID 27423937 DOI: 10.1016/J.Phrs.2016.07.013  0.408
2016 Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI, Alkondon M, Yuan P, Pribut HJ, Singh NS, Dossou KS, Fang Y, Huang XP, Mayo CL, Wainer IW, et al. NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature. PMID 27144355 DOI: 10.1038/Nature17998  0.408
2016 Singh NS, Rutkowska E, Plazinska A, Khadeer M, Moaddel R, Jozwiak K, Bernier M, Wainer IW. Ketamine Metabolites Enantioselectively Decrease Intracellular D-Serine Concentrations in PC-12 Cells. Plos One. 11: e0149499. PMID 27096720 DOI: 10.1371/Journal.Pone.0149499  0.779
2016 Moaddel R, Sanghvi M, Ramamoorthy A, Jozwiak K, Singh N, Green C, O'Loughlin K, Torjman M, Wainer IW. Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats. Journal of Pharmaceutical and Biomedical Analysis. PMID 27017097 DOI: 10.1016/J.Jpba.2016.03.030  0.751
2016 Ciesla L, Okine M, Rosenberg A, Dossou KSS, Toll L, Wainer IW, Moaddel R. Development and characterization of the α3β4α5 nicotinic receptor cellular membrane affinity chromatography column and its application for on line screening of plant extracts. Journal of Chromatography. A. 1431: 138-144. PMID 26774122 DOI: 10.1016/J.Chroma.2015.12.065  0.358
2015 Littmann T, Göttle M, Reinartz MT, Kälble S, Wainer IW, Ozawa T, Seifert R. Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. The Journal of Pharmacology and Experimental Therapeutics. 355: 183-90. PMID 26306764 DOI: 10.1124/Jpet.115.227959  0.423
2015 Singh NS, Bernier M, Camandola S, Khadeer MA, Moaddel R, Mattson MP, Wainer IW. Enantioselective inhibition of d-serine transport by (S)-ketamine. British Journal of Pharmacology. PMID 26140427 DOI: 10.1111/Bph.13239  0.354
2015 Wnorowski A, Sadowska M, Paul RK, Singh NS, Boguszewska-Czubara A, Jimenez L, Abdelmohsen K, Toll L, Jozwiak K, Bernier M, Wainer IW. Activation of β2-adrenergic receptor by (R,R')-4'-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells. Cellular Signalling. 27: 997-1007. PMID 25703025 DOI: 10.1016/J.Cellsig.2015.02.012  0.814
2015 Reinartz MT, Kälble S, Wainer IW, Seifert R. Interaction of fenoterol stereoisomers with β2-adrenoceptor-G sα fusion proteins: antagonist and agonist competition binding. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 517-24. PMID 25637582 DOI: 10.1007/S00210-015-1086-5  0.434
2015 Reinartz MT, Kälble S, Littmann T, Ozawa T, Dove S, Kaever V, Wainer IW, Seifert R. Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 51-65. PMID 25342094 DOI: 10.1007/S00210-014-1054-5  0.382
2015 Moaddel R, Luckenbaugh DA, Xie Y, Villaseñor A, Brutsche NE, Machado-Vieira R, Ramamoorthy A, Lorenzo MP, Garcia A, Bernier M, Torjman MC, Barbas C, Zarate CA, Wainer IW. D-serine plasma concentration is a potential biomarker of (R, S)-ketamine antidepressant response in subjects with treatment-resistant depression Psychopharmacology. 232: 399-409. PMID 25056852 DOI: 10.1007/S00213-014-3669-0  0.346
2015 Singh NS, Catazaro J, Bernier M, Powers R, Wainer I. Abstract 1172: (R,R’)-4′-Methoxy-1-naphthylfenoterol decreases glycolytic activity in the PANC-1 pancreatic cancer cell line Cancer Research. 75: 1172-1172. DOI: 10.1158/1538-7445.Am2015-1172  0.344
2015 Singh N, Bernier M, Wainer IW. Abstract LB-C13: Selective GPR55 antagonism attenuates EGFR-PKM2-β-catenin signaling and reduces chemoresistance in PANC-1 pancreatic cancer cells Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-Lb-C13  0.371
2014 Jozwiak K, Targowska-Duda KM, Kaczor AA, Kozak J, Ligeza A, Szacon E, Wrobel TM, Budzynska B, Biala G, Fornal E, Poso A, Wainer IW, Matosiuk D. Synthesis, in vitro and in vivo studies, and molecular modeling of N-alkylated dextromethorphan derivatives as non-competitive inhibitors of α3β4 nicotinic acetylcholine receptor. Bioorganic & Medicinal Chemistry. 22: 6846-56. PMID 25464883 DOI: 10.1016/J.Bmc.2014.10.036  0.802
2014 Singh NS, Zarate CA, Moaddel R, Bernier M, Wainer IW. What is hydroxynorketamine and what can it bring to neurotherapeutics? Expert Review of Neurotherapeutics. 14: 1239-42. PMID 25331415 DOI: 10.1586/14737175.2014.971760  0.421
2014 Paul RK, Singh NS, Khadeer M, Moaddel R, Sanghvi M, Green CE, O'Loughlin K, Torjman MC, Bernier M, Wainer IW. (R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function. Anesthesiology. 121: 149-59. PMID 24936922 DOI: 10.1097/Aln.0000000000000285  0.363
2014 Woo AY, Jozwiak K, Toll L, Tanga MJ, Kozocas JA, Jimenez L, Huang Y, Song Y, Plazinska A, Pajak K, Paul RK, Bernier M, Wainer IW, Xiao RP. Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor. The Journal of Biological Chemistry. 289: 19351-63. PMID 24831005 DOI: 10.1074/Jbc.M114.558882  0.791
2014 Singh NS, Habicht KL, Dossou KSS, Shimmo R, Wainer IW, Moaddel R. Multiple protein stationary phases: A review Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 968: 64-68. PMID 24780640 DOI: 10.1016/J.Jchromb.2014.04.005  0.302
2014 Tedesco D, Zanasi R, Wainer IW, Bertucci C. Stereochemical and conformational study on fenoterol by ECD spectroscopy and TD-DFT calculations. Journal of Pharmaceutical and Biomedical Analysis. 91: 92-6. PMID 24441217 DOI: 10.1016/J.Jpba.2013.12.018  0.414
2014 Paul RK, Wnorowski A, Gonzalez-Mariscal I, Nayak SK, Pajak K, Moaddel R, Indig FE, Bernier M, Wainer IW. (R,R')-4'-methoxy-1-naphthylfenoterol targets GPR55-mediated ligand internalization and impairs cancer cell motility. Biochemical Pharmacology. 87: 547-61. PMID 24355564 DOI: 10.1016/J.Bcp.2013.11.020  0.794
2014 Plazinska A, Pajak K, Rutkowska E, Jimenez L, Kozocas J, Koolpe G, Tanga M, Toll L, Wainer IW, Jozwiak K. Comparative molecular field analysis of fenoterol derivatives interacting with an agonist-stabilized form of the β₂-adrenergic receptor. Bioorganic & Medicinal Chemistry. 22: 234-46. PMID 24326276 DOI: 10.1016/J.Bmc.2013.11.030  0.796
2014 Paul RK, Wnorowski A, Bernier M, Wainer IW. Abstract 4535: Inhibition of cell proliferation by (R,R')-4′-methoxy-1-naphthylfenoterol in breast cancer cell lines Cancer Research. 74: 4535-4535. DOI: 10.1158/1538-7445.Am2014-4535  0.811
2014 Wnorowski A, Paul RK, Jimenez L, Toll L, Kotb A, Bernier M, Wainer IW. Abstract 3680: (R,R')-4′-methoxy-1-naphtylfenoterol inhibits pro-survival signaling, proliferation and motility of select human melanoma cell lines Cancer Research. 74: 3680-3680. DOI: 10.1158/1538-7445.Am2014-3680  0.818
2013 Bernier M, Paul RK, Dossou KS, Wnorowski A, Ramamoorthy A, Paris A, Moaddel R, Cloix JF, Wainer IW. Antitumor activity of (R,R')-4-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse. Pharmacology Research & Perspectives. 1: e00010. PMID 25505565 DOI: 10.1002/Prp2.10  0.81
2013 Plazinska A, Kolinski M, Wainer IW, Jozwiak K. Molecular interactions between fenoterol stereoisomers and derivatives and the β₂-adrenergic receptor binding site studied by docking and molecular dynamics simulations. Journal of Molecular Modeling. 19: 4919-30. PMID 24043542 DOI: 10.1007/S00894-013-1981-Y  0.816
2013 Singh NS, Paul RK, Ramamoorthy A, Torjman MC, Moaddel R, Bernier M, Wainer IW. Nicotinic acetylcholine receptor antagonists alter the function and expression of serine racemase in PC-12 and 1321N1 cells. Cellular Signalling. 25: 2634-45. PMID 24012499 DOI: 10.1016/J.Cellsig.2013.08.025  0.404
2013 Sanghvi M, Ramamoorthy A, Strait J, Wainer IW, Moaddel R. Development and validation of a sensitive LC-MS/MS method for the determination of fenoterol in human plasma and urine samples Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 933: 37-43. PMID 23872161 DOI: 10.1016/J.Jchromb.2013.06.020  0.38
2013 Singh NS, Paul RK, Torjman MC, Wainer IW. Gabapentin and (S)-pregabalin decrease intracellular D-serine concentrations in PC-12 cells. Neuroscience Letters. 535: 90-4. PMID 23274708 DOI: 10.1016/J.Neulet.2012.12.024  0.302
2013 Moaddel R, Abdrakhmanova G, Kozak J, Jozwiak K, Toll L, Jimenez L, Rosenberg A, Tran T, Xiao Y, Zarate CA, Wainer IW. Sub-anesthetic concentrations of (R,S)-ketamine metabolites inhibit acetylcholine-evoked currents in α7 nicotinic acetylcholine receptors. European Journal of Pharmacology. 698: 228-34. PMID 23183107 DOI: 10.1016/J.Ejphar.2012.11.023  0.78
2013 Habicht KL, Frazier C, Singh N, Shimmo R, Wainer IW, Moaddel R. The synthesis and characterization of a nuclear membrane affinity chromatography column for the study of human breast cancer resistant protein (BCRP) using nuclear membranes obtained from the LN-229 cells. Journal of Pharmaceutical and Biomedical Analysis. 72: 159-62. PMID 23146242 DOI: 10.1016/J.Jpba.2012.10.001  0.318
2013 Paul RK, Wnorowski A, Gonzalez-Mariscal I, Moaddel R, Indig FE, Wainer IW, Bernier M. Abstract 5516: (R,R’)-4’-methoxy-1-naphthylfenoterol Inhibits GPR55 signaling and the modulation of motility in human cancer cells. Cancer Research. 73: 5516-5516. DOI: 10.1158/1538-7445.Am2013-5516  0.802
2013 Paul RK, Ramamoorthy A, Zhang Y, Becker KG, Paris A, Cloix J, Bernier M, Wainer IW. Abstract 5514: Antitumor activity of (R,R’)-4′-methoxy-1-naphthylfenoterol in a rat C6 glioma xenograft model in the mouse. Cancer Research. 73: 5514-5514. DOI: 10.1158/1538-7445.Am2013-5514  0.325
2013 Paul RK, Wnorowski A, Indig FE, Bernier M, Wainer IW. Abstract 1023: Regulation of cell proliferation by GPR55/cannabinoid receptors using (R,R’)-4’-methoxy-1-naphthylfenoterol in rat C6 glioma cell line. Cancer Research. 73: 1023-1023. DOI: 10.1158/1538-7445.Am2013-1023  0.818
2012 Paul RK, Ramamoorthy A, Scheers J, Wersto RP, Toll L, Jimenez L, Bernier M, Wainer IW. Cannabinoid receptor activation correlates with the proapoptotic action of the β2-adrenergic agonist (R,R')-4-methoxy-1-naphthylfenoterol in HepG2 hepatocarcinoma cells. The Journal of Pharmacology and Experimental Therapeutics. 343: 157-66. PMID 22776956 DOI: 10.1124/Jpet.112.195206  0.471
2012 Iyer LV, Ramamoorthy A, Rutkowska E, Furimsky AM, Tang L, Catz P, Green CE, Jozwiak K, Wainer IW. The stereoselective sulfate conjugation of 4'-methoxyfenoterol stereoisomers by sulfotransferase enzymes. Chirality. 24: 796-803. PMID 22744891 DOI: 10.1002/Chir.22072  0.801
2012 Desta Z, Moaddel R, Ogburn ET, Xu C, Ramamoorthy A, Venkata SL, Sanghvi M, Goldberg ME, Torjman MC, Wainer IW. Stereoselective and regiospecific hydroxylation of ketamine and norketamine. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 42: 1076-87. PMID 22612619 DOI: 10.3109/00498254.2012.685777  0.37
2012 Toll L, Pajak K, Plazinska A, Jozwiak K, Jimenez L, Kozocas JA, Tanga MJ, Bupp JE, Wainer IW. Thermodynamics and docking of agonists to the β(2)-adrenoceptor determined using [(3)H](R,R')-4-methoxyfenoterol as the marker ligand. Molecular Pharmacology. 81: 846-54. PMID 22434858 DOI: 10.1124/Mol.111.077347  0.808
2012 Singh NS, Paul RK, Sichler M, Moaddel R, Bernier M, Wainer IW. Capillary electrophoresis-laser-induced fluorescence (CE-LIF) assay for measurement of intracellular D-serine and serine racemase activity. Analytical Biochemistry. 421: 460-6. PMID 22037294 DOI: 10.1016/J.Ab.2011.10.003  0.335
2011 Jozwiak K, Plazinska A, Toll L, Jimenez L, Woo AY, Xiao RP, Wainer IW. Effect of fenoterol stereochemistry on the β2 adrenergic receptor system: ligand-directed chiral recognition. Chirality. 23: E1-6. PMID 21618615 DOI: 10.1002/Chir.20963  0.824
2011 Moaddel R, Rosenberg A, Spelman K, Frazier J, Frazier C, Nocerino S, Brizzi A, Mugnaini C, Wainer IW. Development and characterization of immobilized cannabinoid receptor (CB1/CB2) open tubular column for on-line screening. Analytical Biochemistry. 412: 85-91. PMID 21215722 DOI: 10.1016/J.Ab.2010.12.034  0.378
2011 Toll L, Jimenez L, Waleh N, Jozwiak K, Woo AY, Xiao RP, Bernier M, Wainer IW. {Beta}2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells. The Journal of Pharmacology and Experimental Therapeutics. 336: 524-32. PMID 21071556 DOI: 10.1124/Jpet.110.173971  0.78
2011 Goldberg ME, Torjman MC, Schwartzman RJ, Mager DE, Wainer IW. Enantioselective pharmacokinetics of (R)- and (S)-ketamine after a 5-day infusion in patients with complex regional pain syndrome. Chirality. 23: 138-43. PMID 20803495 DOI: 10.1002/Chir.20890  0.34
2010 Moaddel R, Venkata SL, Tanga MJ, Bupp JE, Green CE, Iyer L, Furimsky A, Goldberg ME, Torjman MC, Wainer IW. A parallel chiral-achiral liquid chromatographic method for the determination of the stereoisomers of ketamine and ketamine metabolites in the plasma and urine of patients with complex regional pain syndrome. Talanta. 82: 1892-904. PMID 20875593 DOI: 10.1016/J.Talanta.2010.08.005  0.384
2010 Arias HR, Rosenberg A, Targowska-Duda KM, Feuerbach D, Yuan XJ, Jozwiak K, Moaddel R, Wainer IW. Interaction of ibogaine with human alpha3beta4-nicotinic acetylcholine receptors in different conformational states. The International Journal of Biochemistry & Cell Biology. 42: 1525-35. PMID 20684041 DOI: 10.1016/J.Biocel.2010.05.011  0.795
2010 Sanghvi M, Moaddel R, Frazier C, Wainer IW. Synthesis and characterization of liquid chromatographic columns containing the immobilized ligand binding domain of the estrogen related receptor alpha and estrogen related receptor gamma. Journal of Pharmaceutical and Biomedical Analysis. 53: 777-80. PMID 20542653 DOI: 10.1016/J.Jpba.2010.05.016  0.405
2010 Bhatia PA, Moaddel R, Wainer IW. The synthesis and characterization of cellular membrane affinity chromatography columns for the study of human multidrug resistant proteins MRP1, MRP2 and human breast cancer resistant protein BCRP using membranes obtained from Spodoptera frugiperda (Sf9) insect cells. Talanta. 81: 1477-81. PMID 20441926 DOI: 10.1016/J.Talanta.2010.02.055  0.348
2010 Calleri E, Ceruti S, Cristalli G, Martini C, Temporini C, Parravicini C, Volpini R, Daniele S, Caccialanza G, Lecca D, Lambertucci C, Trincavelli ML, Marucci G, Wainer IW, Ranghino G, et al. Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. Journal of Medicinal Chemistry. 53: 3489-501. PMID 20394377 DOI: 10.1021/Jm901691Y  0.383
2010 Arias HR, Rosenberg A, Feuerbach D, Targowska-Duda KM, Maciejewski R, Jozwiak K, Moaddel R, Glick SD, Wainer IW. Interaction of 18-methoxycoronaridine with nicotinic acetylcholine receptors in different conformational states. Biochimica Et Biophysica Acta. 1798: 1153-63. PMID 20303928 DOI: 10.1016/J.Bpj.2010.12.1704  0.802
2010 Kozocas JA, Bupp JE, Tanga MJ, Pluhar JT, Wainer IW. Synthesis of Tritium Labeled (R,R)-4-Methoxyfenoterol. Journal of Labelled Compounds & Radiopharmaceuticals. 53: 68-72. PMID 20228869 DOI: 10.1002/Jlcr.1703  0.374
2010 Arias HR, Rosenberg A, Targowska-Duda KM, Feuerbach D, Jozwiak K, Moaddel R, Wainer IW. Tricyclic antidepressants and mecamylamine bind to different sites in the human alpha4beta2 nicotinic receptor ion channel. The International Journal of Biochemistry & Cell Biology. 42: 1007-18. PMID 20223294 DOI: 10.1016/J.Biocel.2010.03.002  0.806
2010 Moaddel R, Bighi F, Yamaguchi R, Patel S, Ravichandran S, Wainer IW. Stereoselective binding of chiral ligands to single nucleotide polymorphisms of the human organic cation transporter-1 determined using cellular membrane affinity chromatography. Analytical Biochemistry. 401: 148-53. PMID 20206116 DOI: 10.1016/J.Ab.2010.02.034  0.322
2010 Jozwiak K, Toll L, Jimenez L, Woo AY, Xiao RP, Wainer IW. The effect of stereochemistry on the thermodynamic characteristics of the binding of fenoterol stereoisomers to the beta(2)-adrenoceptor. Biochemical Pharmacology. 79: 1610-5. PMID 20144591 DOI: 10.1016/J.Bcp.2010.01.035  0.764
2010 Siluk D, Mager DE, Kim HS, Wang Y, Furimsky AM, Ta A, Iyer LV, Green CE, Wainer IW. Pharmacokinetics and metabolism of (R,R)-methoxyfenoterol in rat. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 40: 195-206. PMID 20039779 DOI: 10.3109/00498250903434533  0.383
2010 Jozwiak K, Woo AY, Tanga MJ, Toll L, Jimenez L, Kozocas JA, Plazinska A, Xiao RP, Wainer IW. Comparative molecular field analysis of fenoterol derivatives: A platform towards highly selective and effective beta(2)-adrenergic receptor agonists. Bioorganic & Medicinal Chemistry. 18: 728-36. PMID 20036561 DOI: 10.1016/J.Bmc.2009.11.062  0.785
2010 Gandhari MK, Frazier CR, Hartenstein JS, Cloix JF, Bernier M, Wainer IW. Identification and characterization of estrogen receptor-related receptor alpha and gamma in human glioma and astrocytoma cells. Molecular and Cellular Endocrinology. 315: 314-8. PMID 19822186 DOI: 10.1016/J.Mce.2009.10.001  0.376
2010 Moaddel R, Musyimi HK, Sanghvi M, Bashore C, Frazier CR, Khadeer M, Bhatia P, Wainer IW. Synthesis and characterization of a cellular membrane affinity chromatography column containing histamine 1 and P2Y(1) receptors: a multiple G-protein coupled receptor column. Journal of Pharmaceutical and Biomedical Analysis. 52: 416-9. PMID 19608372 DOI: 10.1016/J.Jpba.2009.06.035  0.393
2010 Wainer IW, Toll L, Jimenez L, Polgar W, Green C, Gow J, O'Loughlin K, Bernier M. Abstract 724: Selective β2-adrenergic receptor agonists inhibit the proliferation of 1321N1 astrocytoma cells Cancer Research. 70: 724-724. DOI: 10.1158/1538-7445.Am10-724  0.421
2010 Sanghvi M, Moaddel R, Frazier C, Gandhari M, Wainer IW. Abstract 5500: Biochromatography for the screening of new drugs for the estrogen related receptors Cancer Research. 70: 5500-5500. DOI: 10.1158/1538-7445.Am10-5500  0.401
2009 Arias HR, Gumilar F, Rosenberg A, Targowska-Duda KM, Feuerbach D, Jozwiak K, Moaddel R, Wainer IW, Bouzat C. Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states. Biochemistry. 48: 4506-18. PMID 19334677 DOI: 10.1021/Bi802206K  0.79
2009 Moaddel R, Wainer IW. The preparation and development of cellular membrane affinity chromatography columns. Nature Protocols. 4: 197-205. PMID 19180089 DOI: 10.1038/Nprot.2008.225  0.311
2009 Cannazza G, Jozwiak K, Parenti C, Braghiroli D, Carrozzo MM, Puia G, Losi G, Baraldi M, Lindner W, Wainer IW. A novel class of allosteric modulators of AMPA/Kainate receptors. Bioorganic & Medicinal Chemistry Letters. 19: 1254-7. PMID 19162477 DOI: 10.1016/J.Bmcl.2008.12.094  0.725
2009 Woo AY, Wang TB, Zeng X, Zhu W, Abernethy DR, Wainer IW, Xiao RP. Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. Molecular Pharmacology. 75: 158-65. PMID 18838481 DOI: 10.1124/Mol.108.051078  0.425
2009 Kim HS, Siluk D, Wainer IW. Quantitative determination of fenoterol and fenoterol derivatives in rat plasma using on-line immunoextraction and liquid chromatography/mass spectrometry. Journal of Chromatography. A. 1216: 3526-32. PMID 18778830 DOI: 10.1016/J.Chroma.2008.08.046  0.397
2008 Kitabatake T, Moaddel R, Cole R, Gandhari M, Frazier C, Hartenstein J, Rosenberg A, Bernier M, Wainer IW. Characterization of a multiple ligand-gated ion channel cellular membrane affinity chromatography column and identification of endogenously expressed receptors in astrocytoma cell lines. Analytical Chemistry. 80: 8673-80. PMID 18847217 DOI: 10.1021/Ac8016407  0.387
2008 Jozwiak K, Moaddel R, Ravichandran S, Plazinska A, Kozak J, Patel S, Yamaguchi R, Wainer IW. Exploring enantiospecific ligand-protein interactions using cellular membrane affinity chromatography: chiral recognition as a dynamic process. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 875: 200-7. PMID 18723411 DOI: 10.1016/J.Jchromb.2008.07.048  0.8
2008 Bhatia P, Kolinski M, Moaddel R, Jozwiak K, Wainer IW. Determination and modelling of stereoselective interactions of ligands with drug transporters: a key dimension in the understanding of drug disposition. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 38: 656-75. PMID 18668426 DOI: 10.1080/00498250802109207  0.722
2008 Siluk D, Kim HS, Cole T, Wainer IW. HPLC-electrospray mass spectrometric assay for the determination of (R,R)-fenoterol in rat plasma. Journal of Pharmaceutical and Biomedical Analysis. 48: 960-4. PMID 18617349 DOI: 10.1016/J.Jpba.2008.05.034  0.375
2008 Kim HS, Wainer IW. Rapid analysis of the interactions between drugs and human serum albumin (HSA) using high-performance affinity chromatography (HPAC). Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 870: 22-6. PMID 18554995 DOI: 10.1016/J.Jchromb.2008.05.029  0.338
2008 Maciuk A, Moaddel R, Haginaka J, Wainer IW. Screening of tobacco smoke condensate for nicotinic acetylcholine receptor ligands using cellular membrane affinity chromatography columns and missing peak chromatography. Journal of Pharmaceutical and Biomedical Analysis. 48: 238-46. PMID 18187282 DOI: 10.1016/J.Jpba.2007.11.024  0.403
2008 Moaddel R, Oliveira RV, Kimura T, Hyppolite P, Juhaszova M, Xiao Y, Kellar KJ, Bernier M, Wainer IW. Initial synthesis and characterization of an alpha7 nicotinic receptor cellular membrane affinity chromatography column: effect of receptor subtype and cell type. Analytical Chemistry. 80: 48-54. PMID 18062706 DOI: 10.1021/Ac701943B  0.328
2008 Marszałł MP, Moaddel R, Jozwiak K, Bernier M, Wainer IW. Initial synthesis and characterization of an immobilized heat shock protein 90 column for online determination of binding affinities. Analytical Biochemistry. 373: 313-21. PMID 18047824 DOI: 10.1016/J.Ab.2007.11.001  0.727
2008 Jozwiak K, Moaddel R, Wainer IW, Arias H. Interaction of ibogaine analogs with the nicotinic acetylcholine receptor The Faseb Journal. 22: 620-620. DOI: 10.1096/Fasebj.22.2_Supplement.620  0.742
2007 Jozwiak K, Ravichandran S, Collins JR, Moaddel R, Wainer IW. Interaction of noncompetitive inhibitors with the alpha3beta2 nicotinic acetylcholine receptor investigated by affinity chromatography and molecular docking. Journal of Medicinal Chemistry. 50: 6279-83. PMID 17973360 DOI: 10.1021/Jm070784S  0.752
2007 Siluk D, Mager DE, Gronich N, Abernethy D, Wainer IW. HPLC-atmospheric pressure chemical ionization mass spectrometric method for enantioselective determination of R,S-propranolol and R,S-hyoscyamine in human plasma. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 859: 213-21. PMID 17951120 DOI: 10.1016/J.Jchromb.2007.09.035  0.379
2007 Oliveira RV, Onorato JM, Siluk D, Walko CM, Lindley C, Wainer IW. Enantioselective liquid chromatography-mass spectrometry assay for the determination of ifosfamide and identification of the N-dechloroethylated metabolites of ifosfamide in human plasma. Journal of Pharmaceutical and Biomedical Analysis. 45: 295-303. PMID 17855037 DOI: 10.1016/J.Jpba.2007.07.026  0.375
2007 Jozwiak K, Khalid C, Tanga MJ, Berzetei-Gurske I, Jimenez L, Kozocas JA, Woo A, Zhu W, Xiao RP, Abernethy DR, Wainer IW. Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. Journal of Medicinal Chemistry. 50: 2903-15. PMID 17506540 DOI: 10.1021/Jm070030D  0.78
2007 Moaddel R, Calleri E, Massolini G, Frazier CR, Wainer IW. The synthesis and initial characterization of an immobilized purinergic receptor (P2Y1) liquid chromatography stationary phase for online screening. Analytical Biochemistry. 364: 216-8. PMID 17391632 DOI: 10.1016/J.Ab.2007.02.014  0.436
2007 Moaddel R, Jozwiak K, Wainer IW. Allosteric modifiers of neuronal nicotinic acetylcholine receptors: new methods, new opportunities. Medicinal Research Reviews. 27: 723-53. PMID 17238157 DOI: 10.1002/Med.20091  0.742
2007 Rodriguez-Rosas ME, Lofwall MR, Strain EC, Siluk D, Wainer IW. Simultaneous determination of buprenorphine, norbuprenorphine and the enantiomers of methadone and its metabolite (EDDP) in human plasma by liquid chromatography/mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 850: 538-43. PMID 17141582 DOI: 10.1016/J.Jchromb.2006.11.025  0.375
2007 Moaddel R, Wainer IW. Conformational mobility of immobilized proteins. Journal of Pharmaceutical and Biomedical Analysis. 43: 399-406. PMID 17095178 DOI: 10.1016/J.Jpba.2006.08.021  0.393
2006 Margaryan A, Moaddel R, Aldrich JR, Tsuruda JM, Chen AM, Leal WS, Wainer IW. Synthesis of an immobilized Bombyx mori pheromone-binding protein liquid chromatography stationary phase. Talanta. 70: 752-5. PMID 18970835 DOI: 10.1016/J.Talanta.2006.01.046  0.335
2006 Moaddel R, Hamid R, Patel S, Bullock PL, Wainer IW. Identification of P-glycoprotein substrates using open tubular chromatography on an immobilized P-glycoprotein column: Comparison of chromatographic results with Caco-2 permeability. Analytica Chimica Acta. 578: 25-30. PMID 17723691 DOI: 10.1016/J.Aca.2006.03.007  0.316
2006 Moaddel R, Wainer IW. Development of immobilized membrane-based affinity columns for use in the online characterization of membrane bound proteins and for targeted affinity isolations. Analytica Chimica Acta. 564: 97-105. PMID 17723367 DOI: 10.1016/J.Aca.2005.09.020  0.344
2006 Jozwiak K, Moaddel R, Yamaguchi R, Maciuk A, Wainer IW. Non-competitive inhibitory activities of morphinan and morphine derivatives at the alpha 3 beta 4 Neuronal nicotinic acetylcholine receptor determined using nonlinear chromatography and chemometric techniques. Pharmaceutical Research. 23: 2175-82. PMID 16952007 DOI: 10.1007/S11095-006-9088-0  0.728
2006 Beigi F, Bertucci C, Zhu W, Chakir K, Wainer IW, Xiao RP, Abernethy DR. Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality. 18: 822-7. PMID 16917835 DOI: 10.1002/Chir.20317  0.375
2005 Moaddel R, Patel S, Jozwiak K, Yamaguchi R, Ho PC, Wainer IW. Enantioselective binding to the human organic cation transporter-1 (hOCT1) determined using an immobilized hOCT1 liquid chromatographic stationary phase. Chirality. 17: 501-6. PMID 16113995 DOI: 10.1002/Chir.20195  0.358
2005 Moaddel R, Jozwiak K, Yamaguchi R, Wainer IW. Direct chromatographic determination of dissociation rate constants of ligand-receptor complexes: assessment of the interaction of noncompetitive inhibitors with an immobilized nicotinic acetylcholine receptor-based liquid chromatography stationary phase. Analytical Chemistry. 77: 5421-6. PMID 16097790 DOI: 10.1021/Ac0504464  0.761
2005 Rodriguez-Rosas ME, Medrano JG, Epstein DH, Moolchan ET, Preston KL, Wainer IW. Determination of total and free concentrations of the enantiomers of methadone and its metabolite (2-ethylidene-1,5-dimethyl-3,3-diphenyl-pyrrolidine) in human plasma by enantioselective liquid chromatography with mass spectrometric detection. Journal of Chromatography. A. 1073: 237-48. PMID 15909525 DOI: 10.1016/J.Chroma.2004.08.153  0.37
2005 Jozwiak K, Moaddel R, Yamaguchi R, Ravichandran S, Collins JR, Wainer IW. Qualitative assessment of IC50 values of inhibitors of the neuronal nicotinic acetylcholine receptor using a single chromatographic experiment and multivariate cluster analysis. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 819: 169-74. PMID 15797535 DOI: 10.1016/J.Jchromb.2005.01.043  0.739
2005 Moaddel R, Yamaguchi R, Ho PC, Patel S, Hsu CP, Subrahmanyam V, Wainer IW. Development and characterization of an immobilized human organic cation transporter based liquid chromatographic stationary phase. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 818: 263-8. PMID 15734168 DOI: 10.1016/J.Jchromb.2005.01.015  0.388
2005 Moaddel R, Jozwiak K, Whittington K, Wainer IW. Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors. Analytical Chemistry. 77: 895-901. PMID 15679359 DOI: 10.1021/Ac048826X  0.765
2005 Calleri E, Marrubini G, Massolini G, Lubda D, de Fazio SS, Furlanetto S, Wainer IW, Manzo L, Caccialanza G. Development of a chromatographic bioreactor based on immobilized beta-glucuronidase on monolithic support for the determination of dextromethorphan and dextrorphan in human urine. Journal of Pharmaceutical and Biomedical Analysis. 35: 1179-89. PMID 15336363 DOI: 10.1016/J.Jpba.2004.02.033  0.301
2004 Sarkar TK, Basak S, Wainer I, Moaddel R, Yamaguchi R, Jozwiak K, Chen HT, Lin CC. Coaxing a pyridine nucleus to give up its aromaticity: synthesis and pharmacological characterization of novel conformationally restricted analogues of nicotine and anabasine. Journal of Medicinal Chemistry. 47: 6691-701. PMID 15615518 DOI: 10.1021/Jm049707C  0.738
2004 Beigi F, Chakir K, Xiao RP, Wainer IW. G-protein-coupled receptor chromatographic stationary phases. 2. Ligand-induced conformational mobility in an immobilized beta2-adrenergic receptor. Analytical Chemistry. 76: 7187-93. PMID 15595859 DOI: 10.1021/Ac048910C  0.425
2004 Moaddel R, Jozwiak K, Yamaguchi R, Cobello C, Whittington K, Sarkar TK, Basak S, Wainer IW. On-line screening of conformationally constrained nicotines and anabasines for agonist activity at the alpha3beta4- and alpha4beta2-nicotinic acetylcholine receptors using immobilized receptor-based liquid chromatographic stationary phases. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 813: 235-40. PMID 15556538 DOI: 10.1016/J.Jchromb.2004.09.042  0.754
2004 Jozwiak K, Ravichandran S, Collins JR, Wainer IW. Interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor investigated by affinity chromatography, quantitative-structure activity relationship analysis, and molecular docking. Journal of Medicinal Chemistry. 47: 4008-21. PMID 15267239 DOI: 10.1021/Jm0400707  0.756
2004 Williams ML, Mager DE, Parenteau H, Gudi G, Tracy TS, Mulheran M, Wainer IW. Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 32: 786-93. PMID 15258102 DOI: 10.1124/Dmd.32.8.786  0.304
2004 Markoglou N, Hsuesh R, Wainer IW. Immobilized enzyme reactors based upon the flavoenzymes monoamine oxidase A and B. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 804: 295-302. PMID 15081923 DOI: 10.1016/J.Jchromb.2004.01.031  0.758
2004 Moaddel R, Bullock PL, Wainer IW. Development and characterization of an open tubular column containing immobilized P-glycoprotein for rapid on-line screening for P-glycoprotein substrates. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 799: 255-63. PMID 14670744 DOI: 10.1016/J.Jchromb.2003.10.054  0.368
2004 Rodriguez Rosas ME, Patel S, Wainer IW. Determination of the enantiomers of ketamine and norketamine in human plasma by enantioselective liquid chromatography-mass spectrometry. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 794: 99-108. PMID 12888202 DOI: 10.1016/S1570-0232(03)00420-3  0.324
2003 Beigi F, Wainer IW. Syntheses of immobilized G protein-coupled receptor chromatographic stationary phases: characterization of immobilized mu and kappa opioid receptors. Analytical Chemistry. 75: 4480-5. PMID 14632053 DOI: 10.1021/Ac034385Q  0.391
2003 Jozwiak K, Hernandez SC, Kellar KJ, Wainer IW. Enantioselective interactions of dextromethorphan and levomethorphan with the alpha 3 beta 4-nicotinic acetylcholine receptor: comparison of chromatographic and functional data. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 797: 373-9. PMID 14630163 DOI: 10.1016/S1570-0232(03)00608-1  0.741
2003 Rosas ME, Preston KL, Epstein DH, Moolchan ET, Wainer IW. Quantitative determination of the enantiomers of methadone and its metabolite (EDDP) in human saliva by enantioselective liquid chromatography with mass spectrometric detection. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 796: 355-70. PMID 14581075 DOI: 10.1016/J.Jchromb.2003.08.017  0.323
2003 Moaddel R, Wainer IW. Immobilized nicotinic receptor stationary phases: going with the flow in high-throughput screening and pharmacological studies. Journal of Pharmaceutical and Biomedical Analysis. 30: 1715-24. PMID 12485712 DOI: 10.1016/S0731-7085(02)00513-7  0.374
2002 Markoglou N, Wainer IW. Biosynthesis in an on-line immobilized-enzyme reactor containing phenylethanolamine N-methyltransferase in single-enzyme and coupled-enzyme formats. Journal of Chromatography. A. 948: 249-56. PMID 12831201 DOI: 10.1016/S0021-9673(01)01474-1  0.747
2002 Jozwiak K, Haginaka J, Moaddel R, Wainer IW. Displacement and nonlinear chromatographic techniques in the investigation of interaction of noncompetitive inhibitors with an immobilized alpha3beta4 nicotinic acetylcholine receptor liquid chromatographic stationary phase. Analytical Chemistry. 74: 4618-24. PMID 12349962 DOI: 10.1021/Ac0202029  0.743
2002 Baynham MT, Patel S, Moaddel R, Wainer IW. Multidimensional on-line screening for ligands to the alpha3beta4 neuronal nicotinic acetylcholine receptor using an immobilized nicotinic receptor liquid chromatographic stationary phase. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 772: 155-61. PMID 12016027 DOI: 10.1016/S1570-0232(02)00070-3  0.353
2002 Moaddel R, Lu L, Baynham M, Wainer IW. Immobilized receptor- and transporter-based liquid chromatographic phases for on-line pharmacological and biochemical studies: a mini-review. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 768: 41-53. PMID 11939557 DOI: 10.1016/S0378-4347(01)00484-4  0.398
2002 Williams ML, Wainer IW. Role of chiral chromatography in therapeutic drug monitoring and in clinical and forensic toxicology. Therapeutic Drug Monitoring. 24: 290-6. PMID 11897974 DOI: 10.1097/00007691-200204000-00010  0.3
2002 Markoglou N, Wainer IW. On-line synthesis utilizing immobilized enzyme reactors based upon immobilized dopamine beta-hydroxylase. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 766: 145-51. PMID 11820290 DOI: 10.1016/S0378-4347(01)00458-3  0.763
2001 Bendriss EK, Markoglou N, Wainer IW. High-performance liquid chromatography assay for simultaneous determination of dextromethorphan and its main metabolites in urine and in microsomal preparations. Journal of Chromatography. B, Biomedical Sciences and Applications. 754: 209-15. PMID 11318417 DOI: 10.1016/S0378-4347(00)00609-5  0.75
2001 Markoglou N, Wainer IW. Synthesis and characterization of immobilized dopamine beta-hydroxylase in membrane-bound and solubilized formats. Journal of Biochemical and Biophysical Methods. 48: 61-75. PMID 11282402 DOI: 10.1016/S0165-022X(00)00142-1  0.749
2001 Markoglou N, Wainer IW. Synthesis and characterization of an immobilized phenylethanolamine N-methyltransferase liquid chromatographic stationary phase. Analytical Biochemistry. 288: 83-8. PMID 11141309 DOI: 10.1006/Abio.2000.4884  0.749
2000 Bendriss EK, Markoglou N, Wainer IW. Liquid chromatographic method for the simultaneous determination of caffeine and fourteen caffeine metabolites in urine. Journal of Chromatography. B, Biomedical Sciences and Applications. 746: 331-8. PMID 11076088 DOI: 10.1016/S0378-4347(00)00325-X  0.748
2000 O'Neil WM, Gilfix BM, Markoglou N, Di Girolamo A, Tsoukas CM, Wainer IW. Genotype and phenotype of cytochrome P450 2D6 in human immunodeficiency virus-positive patients and patients with acquired immunodeficiency syndrome. European Journal of Clinical Pharmacology. 56: 231-40. PMID 10952478  0.722
1999 Bernstein ML, Baruchel S, Devine S, Markoglou N, Wainer IW, Williams M, Blaney S, Moghrabi A, Winick N, Vietti T. Phase I and pharmacokinetic study of CI-980 in recurrent pediatric solid tumor cases: a Pediatric Oncology Group study. Journal of Pediatric Hematology/Oncology. 21: 494-500. PMID 10598660 DOI: 10.1097/00043426-199911000-00010  0.73
1998 Azzaoui K, Diaz-Perez MJ, Zannis-Hadjoupoulos M, Price GB, Wainer IW. Effect of steroids on DNA synthesis in an in vitro replication system: initial quantitative structure-activity relationship studies and construction of a non-estrogen receptor pharmacophore. Journal of Medicinal Chemistry. 41: 1392-8. PMID 9554872 DOI: 10.1021/Jm970725M  0.312
1997 Markoglou N, Wainer IW. Determination of the anticancer agent CI-980 in plasma by achiral liquid chromatography on a Pirkle-type stationary phase. Journal of Chromatography. B, Biomedical Sciences and Applications. 693: 493-7. PMID 9210458 DOI: 10.1016/S0378-4347(97)00077-7  0.749
1995 Aubry AF, Markoglou N, Adams MH, Longstreth J, Wainer IW. The effect of co-administered drugs on oxaprozin binding to human serum albumin. The Journal of Pharmacy and Pharmacology. 47: 937-44. PMID 8708989 DOI: 10.1111/J.2042-7158.1995.Tb03274.X  0.754
1994 Aubry AF, Markoglou N, Descorps V, Wainer IW, Félix G. Evaluation of a chiral stationary phase based on mixed immobilized proteins Journal of Chromatography A. 685: 1-6. DOI: 10.1016/0021-9673(94)00670-9  0.749
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